US20070157654A1 - Cassette and apparatus for liquid freezing - Google Patents
Cassette and apparatus for liquid freezing Download PDFInfo
- Publication number
- US20070157654A1 US20070157654A1 US10/587,144 US58714405A US2007157654A1 US 20070157654 A1 US20070157654 A1 US 20070157654A1 US 58714405 A US58714405 A US 58714405A US 2007157654 A1 US2007157654 A1 US 2007157654A1
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- United States
- Prior art keywords
- cassette
- liquid
- liquid receptacles
- bottom plate
- receptacles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D25/00—Charging, supporting, and discharging the articles to be cooled
- F25D25/04—Charging, supporting, and discharging the articles to be cooled by conveyors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
- A61M1/0277—Frames constraining or supporting bags, e.g. during freezing
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2331/00—Details or arrangements of other cooling or freezing apparatus not provided for in other groups of this subclass
- F25D2331/80—Type of cooled receptacles
- F25D2331/801—Bags
Definitions
- the present invention generally relates to freezing a liquid, particularly blood plasma, in a liquid receptacle. More precisely, the invention relates to a cassette and an apparatus for such a treatment for a relatively large liquid volume, i.e. using a relatively large number of liquid receptacles.
- blood plasma should be frozen as soon as possible after the drawing of the blood and the separation of the blood plasma. More precisely, at most two hours should elapse from the drawing to the start of freezing. The freezing process itself should occur quickly enough for the plasma to reach a temperature of about ⁇ 30° C. within an hour. After freezing, the plasma is normally stored at a temperature of about ⁇ 30° C. while awaiting transportation to, for example, a processing facility.
- liquid receptacles for plasma are plastic bags or essentially parallelepipedal plastic receptacles, so called vials, in which the plasma is kept during handling from the drawing location to the processing location.
- cooling metal blocks having cavities corresponding to the liquid receptacles and cooling air of high speed for freezing the known liquid receptacles. Cooling with air jets is described in more detail in the international patent application WO97/30317.
- EP 0732097 discloses the use of a cassette and a freezing tunnel.
- This cassette has a frame carrying three perforated and fixed plates above each other for supporting a plurality of plasma bags.
- a pressure plate and a spring device are provided above each fixed plate in order to press the plasma bags against the fixed plate.
- this approach is lacking in productivity as the loading and the unloading are circumstantial and the packing density of the plasma bags is low.
- the main object of the present invention is therefore to provide an easy and effective way of handling a relatively large number of liquid receptacles from filling through freezing and to low temperature storage.
- this object is obtained by means of a cassette having the new features defined in claim 1 .
- Preferred embodiments of the cassette are defined in claims 2 - 4 .
- the special plates used make it easy to arrange a batch with a great number of liquid receptacles separate from the freezer tunnel itself and that this batch easily can be pushed Into the freezer tunnel and after freezing as easy be taken out from the freezer tunnel.
- This handling also means that the liquid receptacles at any time may be identified very easily, for example by pointing a bar code reader towards bar codes being fixed on the liquid receptacles when filling the liquid. If the bar code reader is used to register the read data, as well as the time and the identity of the individual using the bar code reader, in a suitable register, the whole treatment process will be traceable for each separate liquid receptacde.
- the cassette has a bottom plate to support a number of liquid receptacles in one layer, and a number of intermediate plates with substantially the same dimensions as the bottom plate to be placed on each layer of the liquid receptacles and each supporting a further layer of liquid receptacles.
- each intermediate plate has means cooperating with the side walls so that each intermediate plate when placed on a layer of liquid receptacles will be fixed lengthwise relative the side walls.
- the liquid receptacles are preferably flexible and each intermediate plate has spacer means to fix the distance to the subjacent intermediate plate and the bottom plate, respectively.
- each intermediate plate have a number of full length ducts which extend in the plane thereof for admitting the cooling medium to flow through them and thereby cool the bottom plate and the intermediate plates when the cassette is in the freezing tunnel.
- a freezer is further provided having the features that are stated in claim 5 .
- Preferred embodiments of the freezer are defined in claims 6 - 10 .
- the freezer has thus a cassette, which contains a bottom plate to support a number of liquid receptacles in a layer and a number of intermediate plates having substantially the same dimensions as the bottom plate to be placed on each layer of liquid receptacles and supporting a further layer of liquid receptacles; a cassette holder, which includes a frame to support the cassette and a number of intermediate plates separated from the cassette; and a freezer tunnel for a streaming cooling medium in which freezing tunnel a cassette with liquid receptacles is inserted from the cassette holder to be kept therein until the liquid in all the liquid receptacles in the cassette is frozen.
- the cassette holder of the freezer preferably has a stand for placing the intermediate plates leaning, in contact with each other and successively displaced in height.
- the cassette holder can further be mobile for movement from a station for loading the cassette with the liquid receptacles and the intermediate plates to the freezing tunnel for inserting the loaded cassette therein.
- the cassette holder can preferably be made mobile by providing wheels on the frame of the cassette holder.
- cooling medium preferably air is used in the freezing tunnel, but also other gaseous cooling media are possible.
- FIG. 1 is a schematic diagram and shows an embodiment of a freezing tunnel in a freezer according to the invention
- FIG. 2 is a perspective of a first embodiment of a cassette holder and a cassette, which is a part of the freezer according to the invention
- FIG. 3 is a plan view of the cassette holder and the cassette in FIG. 2 after being loaded with a number of liquid receptacles;
- FIG. 4 is a cross section view along the line IV-IV in FIG. 3 ;
- FIG. 5 shows in larger scale a partial cross section of one of the intermediate plates in the cassette in FIGS. 24 ;
- FIG. 6 is a side view of a second embodiment of a cassette holder according to the present invention.
- FIG. 7 is a back view of the cassette holder of FIG. 6 .
- an embodiment of a freezer includes a housing 1 , which has a dosed circulation channel 2 .
- a fan 3 is provided in series with a cooling battery 4 and a freezing tunnel 5 .
- a cassette 6 shown in FIGS. 2-4 , can be introduced into the freezing tunnel 5 via an opening in the housing 1 , which can be closed by a lid 7 .
- the fan 3 circulates the air in the circulation channel 2 and thus through the cooling battery 4 , where the air is cooled, and the freezing tunnel 5 , in which the air has a suitable temperature for freezing.
- the cooling battery 4 is via conduits 8 and 9 connected to a conventional cooling unit 10 and can for instance be an evaporator for its cooling medium.
- the cooling unit 10 may be integrated in the housing 1 .
- FIG. 2 shows the cassette 6 and a cassette holder 11 according to a first embodiment.
- the cassette 6 itself has a U-form structure with a bottom plate 12 and two opposite side walls 13 and 14 rigidly connected to the bottom plate 12 .
- a number of rectangular intermediate plates 15 of about the same measures as the bottom plate 12 also belong to the cassette 6 .
- Each intermediate plate 15 can then be put over the bottom plate 12 between the side walls 13 , 14 and be fixed in its position laterally in relation thereto.
- Each intermediate plate 15 has two opposite projections 16 (shown in FIG. 5 ) at two adjacent corners. On each intermediate plate 15 , these projections 16 form means, which can cooperate with recesses 17 in the vertical edges of the side walls 13 , 14 for fixing the position of the intermediate plate 15 lengthwise in relation to the side walls 13 , 14 .
- the cassette holder 11 in FIG. 2 has a support 18 for the cassette 6 and two parallel and recessed guide walls 19 , 20 at the same distance from each other as the side walls 13 , 14 of the cassette.
- a cassette 6 is shown placed on the support 18 with the side walls 13 , 14 as direct extensions of the guide walls 19 , 20 .
- the intermediate plates 15 can then be placed with their projections 16 inserted into their respective recesses 21 in the guide walls 19 , 20 which thus together with a cross bar 22 form a stand for a somewhat sloping placement of the intermediate plates 15 .
- the recesses 21 connect at one of their ends each to a separate one of the recesses 17 , and the other ends of the recesses 21 are displaced in height, so that the intermediate plates 15 , in the sloped placement in the stand, also are displaced in height and in contact with each other.
- the support 18 and the recessed guide walls 19 , 20 of the cassette holder 11 form the upper part of a frame 23 of the same height as the opening in the freezing tunnel 5 .
- the frame 23 is mobile on wheels 24 , which means that the cassette 6 easily can be moved from the cassette holder 11 into the freezing tunnel 5 of the freezer, and vice versa.
- FIGS. 2-4 also illustrate how the loading of the cassette 6 with flexible liquid receptacles 25 is made.
- a number of liquid receptacles 25 are placed in a layer on the bottom plate 12 .
- the intermediate plate 15 positioned next to the cassette 6 is lifted, guided by its projections 16 in the recesses 21 , and is moved in between the side walls 13 , 14 where it is placed on the previously placed layer of liquid receptacles 25 , with its projections 16 inserted each into a separate one of the recesses 17 .
- the position of each intermediate plate 15 position transversely in relation to the bottom plate 12 is thus controlled by the side walls 13 , 14 .
- the position of the intermediate plate 15 lengthwise over the bottom plate 12 is controlled by the engagement of the projections 16 with the recesses 17 .
- each intermediate plate 15 has further a handle 27 , which is positioned between the posts 26 .
- a number of liquid receptacles 25 are placed in a layer on the intermediate plate 15 placed on the liquid receptacles in the second step.
- the second and third steps are repeated in a predetermined number of times, i.e. from zero to so many times as there are available intermediate plates 15 .
- an intermediate plate 15 can be placed on the top layer of the liquid receptacles 25 .
- each intermediate plate 15 has a number of full length ducts, which extend in the plane of the intermediate plate 15 , to admit the cooling medium to flow through them and thereby cool the intermediate plate 15 , when the cassette 6 is in the freezing tunnel 5 .
- the projections 16 are provided each on a separate U-profile which is closely connected to a longitudinal edge of the intermediate plate 15 .
- the bottom plate 12 also has similar full length ducts.
- the intermediate plate 15 is, as the bottom plate 12 , preferably made of a light and good heat-transferring material, for instance aluminum or any other light metal or light metal alloy.
- the intermediate plate 15 can along its side edge with the handle 27 have a number of openings 28 , more precisely one such opening 28 for each liquid receptacle 25 , which is intended to be placed on the intermediate plate 15 .
- These openings 28 are designed for placing test-tubes, which in some cases are annexed each to a separate liquid receptacle 25 .
- Each test-tube contains the same blood plasma as the liquid receptacle to which it is annexed and should be placed in a vertical position during freezing.
- test-tubes may be greater then the height of the posts 26 defining the spacing between the intermediate plates 15 , the test-tubes may be placed in openings alternating between the left and the right half side of the intermediate plates 15 , as illustrated in FIG. 2
- the latter preferably are so flexible as to make contact with the intermediate plates 15 over as large area as possible.
- the invention implies that a cassette 6 can be loaded with liquid receptacles 25 in a simple and ergonomic way, separated from the freezing tunnel 5 itself, for example at a specially for this purpose provided production station. Further, the fully loaded cassette 6 can easily be moved on the cassette holder 11 to the freezing tunnel 5 where it could be docked in order to easily be pushed into this and, after completed freezing of the liquid in the liquid receptacle 25 , as easily be taken out from the freezing tunnel 5 and be placed on the cassette holder 11 , which later easily can be moved to a space, where the frozen liquid receptacles 25 are transferred to package for storing or to transport package for transfer to another place, which is provided for further storage of the liquid receptacles.
- the liquid receptacles 25 with the frozen liquid are easily removed from the cassette 6 by raising the intermediate plates 15 one by one and then pushing each one into its sloped position in the stand 22 - 24 of the cassette holder 11 .
- this later has a number of rolls 29 , on which the cassette 6 is placed. Further, there is a coupling mechanism (not shown) that can keep the cassette 6 in a desired fixed position on the cassette holder 11 and also release the cassette 6 so that it can be pushed on the rolls 29 .
- FIGS. 6 and 7 A second embodiment of a cassette holder 30 is illustrated in FIGS. 6 and 7 as including a lifting equipment 31 for raising and lowering the cassette 6 on the cassette holder 30 such that the intermediate plates 15 may be positioned at substantially the same height in their stand 32 on the cassette holder 30 .
- the lifting equipment 31 illustrated comprises a tresor 33 positioned between an upper plate 34 for carrying the cassette 6 and a lower fixed surface 35 .
- An electric motor 36 is provided for driving an elevating screw 37 to raise or lower the upper plate 34 in accordance with instructions received from a control box 38 .
- the tresor 33 keeps the upper plate 34 horizontal and parallel to the lower fixed surface 35 .
- the stand 32 has two guide walls 39 , 40 , a bottom plate 41 and a back plate 42 .
- the two guide walls 39 , 40 correspond to the guide walls 19 , 20 illustrated in FIGS. 2-4 but have no recesses 21 for the projections 26 of the intermediate plates 15 , since such recesses are unnecessary as the height position of the cassette 6 is adjusted by the lifting equipment.
- the bottom plate 41 may be horizontal or slightly slanting backwards from the cassette 6 .
- the back plate 42 may be substantially vertical or slightly sloping backwards.
- the lifting equipment 31 When starting the loading of a cassette 6 the lifting equipment 31 holds the cassette 6 in an uppermost position. The lifting equipment 31 then lowers the cassette 6 stepwise for each intermediate plate 15 that is to be placed on the liquid receptacles 25 between the side walls 13 , 14 of the cassette 6 . When unloading the liquid receptacles 25 with frozen liquid from the cassette 6 , the lifting equipment 31 first holds the cassette 6 in a lowermost position and then raises the cassette 6 stepwise for each intermediate plate 15 that is raised from the cassette 6 and placed in the stand 32 .
- the stand of the cassette holder 11 for placing of the intermediate plates 15 may be released from the frame 23 of the cassette holder, which means that the stand does not have to follow the cassette 6 , when this is moved on the cassette holder 11 from a production station to the freezing tunnel 5 .
- the stand could also be more or less permanently fixed to the production station.
- the invention is well suited for freezing other liquids, although it is primarily meant for freezing blood plasma.
Abstract
A cassette for use in freezing a liquid contained in a plurality of liquid receptacles comprises a bottom plate for supporting a number of the liquid receptacles in a layer, a number of intermediate plates having essentially the same dimensions as the bottom plate for placing on a layer of the liquid receptacles and supporting a further layer of liquid receptacles, and two opposite side walls being rigidly connected to the bottom plate for constituting a U-form therewith, so that each intermediate plate when placed on a layer of the liquid receptacles will be fixed laterally in relation to the side walls. A freezer for freezing of a liquid contained in a plurality of liquid receptacles comprises a freezing tunnel, the cassette, and a cassette holder having a stand, for supporting the cassette and a number of the intermediate plates separated form the cassette, the cassette holder being mobile for movement from a station for loading of the cassette with the liquid receptacles and the intermediate plates to the freezing tunnel for inserting the loaded cassette therein.
Description
- The present invention generally relates to freezing a liquid, particularly blood plasma, in a liquid receptacle. More precisely, the invention relates to a cassette and an apparatus for such a treatment for a relatively large liquid volume, i.e. using a relatively large number of liquid receptacles.
- It is known from experience that blood plasma should be frozen as soon as possible after the drawing of the blood and the separation of the blood plasma. More precisely, at most two hours should elapse from the drawing to the start of freezing. The freezing process itself should occur quickly enough for the plasma to reach a temperature of about −30° C. within an hour. After freezing, the plasma is normally stored at a temperature of about −30° C. while awaiting transportation to, for example, a processing facility.
- Earlier known examples of liquid receptacles for plasma are plastic bags or essentially parallelepipedal plastic receptacles, so called vials, in which the plasma is kept during handling from the drawing location to the processing location.
- It is also earlier known how to use different forms of cooling liquid baths, cooling metal blocks having cavities corresponding to the liquid receptacles and cooling air of high speed for freezing the known liquid receptacles. Cooling with air jets is described in more detail in the international patent application WO97/30317.
- Most of the known methods for freezing plasma are designed for relatively small plasma quantities, i.e. for a relatively small number of receptacles, and are not suited for enlargement to higher liquid volumes and a consequential higher number of receptacles, as the manual handling of the receptacles would be time-consuming. Reducing the number of receptacles by increasing the volume of each receptacle is not practically possible or even desirable when it comes to blood plasma as the traceability is or may become a demand, which of course means that a blend of blood plasma from for instance different donors cannot be accepted, or in some cases only to a limited extent.
- However, EP 0732097 discloses the use of a cassette and a freezing tunnel. This cassette has a frame carrying three perforated and fixed plates above each other for supporting a plurality of plasma bags. A pressure plate and a spring device are provided above each fixed plate in order to press the plasma bags against the fixed plate. Obviously, this approach is lacking in productivity as the loading and the unloading are circumstantial and the packing density of the plasma bags is low.
- The main object of the present invention is therefore to provide an easy and effective way of handling a relatively large number of liquid receptacles from filling through freezing and to low temperature storage.
- According to the invention, this object is obtained by means of a cassette having the new features defined in
claim 1. Preferred embodiments of the cassette are defined in claims 2-4. - These features enable: that in a first step a number of liquid receptacles are placed in a layer on a bottom plate; that in a second step an intermediate plate is placed on the previous placed layer of liquid receptacles; that in a third step a further number of the liquid receptacles are placed in a layer on the previously placed intermediate plate; that the second and third steps are repeated a predetermined number of times; and that the plates and the liquid receptacles together are pushed into a freezing tunnel with a streaming cooling medium and are kept in the freezing tunnel until the liquid in all liquid receptacles are frozen. Further, since the cassette has two opposite side walls, which are rigidly connected to the bottom plate for constituting a U-form, each intermediate plate when placed on a layer of liquid receptacles will be fixed laterally in relation to the side walls.
- It is obvious that the special plates used make it easy to arrange a batch with a great number of liquid receptacles separate from the freezer tunnel itself and that this batch easily can be pushed Into the freezer tunnel and after freezing as easy be taken out from the freezer tunnel. This handling also means that the liquid receptacles at any time may be identified very easily, for example by pointing a bar code reader towards bar codes being fixed on the liquid receptacles when filling the liquid. If the bar code reader is used to register the read data, as well as the time and the identity of the individual using the bar code reader, in a suitable register, the whole treatment process will be traceable for each separate liquid receptacde.
- Thus, the cassette has a bottom plate to support a number of liquid receptacles in one layer, and a number of intermediate plates with substantially the same dimensions as the bottom plate to be placed on each layer of the liquid receptacles and each supporting a further layer of liquid receptacles.
- Preferably, each intermediate plate has means cooperating with the side walls so that each intermediate plate when placed on a layer of liquid receptacles will be fixed lengthwise relative the side walls.
- The liquid receptacles are preferably flexible and each intermediate plate has spacer means to fix the distance to the subjacent intermediate plate and the bottom plate, respectively.
- Further the bottom plate and each intermediate plate have a number of full length ducts which extend in the plane thereof for admitting the cooling medium to flow through them and thereby cool the bottom plate and the intermediate plates when the cassette is in the freezing tunnel.
- According to the invention a freezer is further provided having the features that are stated in
claim 5. Preferred embodiments of the freezer are defined in claims 6-10. - The freezer has thus a cassette, which contains a bottom plate to support a number of liquid receptacles in a layer and a number of intermediate plates having substantially the same dimensions as the bottom plate to be placed on each layer of liquid receptacles and supporting a further layer of liquid receptacles; a cassette holder, which includes a frame to support the cassette and a number of intermediate plates separated from the cassette; and a freezer tunnel for a streaming cooling medium in which freezing tunnel a cassette with liquid receptacles is inserted from the cassette holder to be kept therein until the liquid in all the liquid receptacles in the cassette is frozen.
- The cassette holder of the freezer preferably has a stand for placing the intermediate plates leaning, in contact with each other and successively displaced in height.
- The cassette holder can further be mobile for movement from a station for loading the cassette with the liquid receptacles and the intermediate plates to the freezing tunnel for inserting the loaded cassette therein.
- The cassette holder can preferably be made mobile by providing wheels on the frame of the cassette holder.
- As cooling medium, preferably air is used in the freezing tunnel, but also other gaseous cooling media are possible.
- Preferred embodiments of the cassette and the freezer according to the present invention will be described in the following with reference to the accompanying drawings, in which:
-
FIG. 1 is a schematic diagram and shows an embodiment of a freezing tunnel in a freezer according to the invention; -
FIG. 2 is a perspective of a first embodiment of a cassette holder and a cassette, which is a part of the freezer according to the invention; -
FIG. 3 is a plan view of the cassette holder and the cassette inFIG. 2 after being loaded with a number of liquid receptacles; -
FIG. 4 is a cross section view along the line IV-IV inFIG. 3 ; -
FIG. 5 shows in larger scale a partial cross section of one of the intermediate plates in the cassette inFIGS. 24 ; -
FIG. 6 is a side view of a second embodiment of a cassette holder according to the present invention; and -
FIG. 7 is a back view of the cassette holder ofFIG. 6 . - Referring to
FIG. 1 , an embodiment of a freezer includes ahousing 1, which has a dosedcirculation channel 2. In this channel 2 afan 3 is provided in series with acooling battery 4 and afreezing tunnel 5. Acassette 6, shown inFIGS. 2-4 , can be introduced into thefreezing tunnel 5 via an opening in thehousing 1, which can be closed by a lid 7. - In operation, the
fan 3 circulates the air in thecirculation channel 2 and thus through thecooling battery 4, where the air is cooled, and thefreezing tunnel 5, in which the air has a suitable temperature for freezing. - The
cooling battery 4 is viaconduits conventional cooling unit 10 and can for instance be an evaporator for its cooling medium. Alternatively, thecooling unit 10 may be integrated in thehousing 1. -
FIG. 2 shows thecassette 6 and acassette holder 11 according to a first embodiment. Thecassette 6 itself has a U-form structure with abottom plate 12 and twoopposite side walls bottom plate 12. A number of rectangularintermediate plates 15 of about the same measures as thebottom plate 12 also belong to thecassette 6. Eachintermediate plate 15 can then be put over thebottom plate 12 between theside walls intermediate plate 15 has two opposite projections 16 (shown inFIG. 5 ) at two adjacent corners. On eachintermediate plate 15, theseprojections 16 form means, which can cooperate withrecesses 17 in the vertical edges of theside walls intermediate plate 15 lengthwise in relation to theside walls - The
cassette holder 11 inFIG. 2 has asupport 18 for thecassette 6 and two parallel andrecessed guide walls side walls cassette 6 is shown placed on thesupport 18 with theside walls guide walls intermediate plates 15 can then be placed with theirprojections 16 inserted into theirrespective recesses 21 in theguide walls cross bar 22 form a stand for a somewhat sloping placement of theintermediate plates 15. In the position shown forcassette 6 in the cassette holder 11 (FIGS. 2-4 ), therecesses 21 connect at one of their ends each to a separate one of therecesses 17, and the other ends of therecesses 21 are displaced in height, so that theintermediate plates 15, in the sloped placement in the stand, also are displaced in height and in contact with each other. - The
support 18 and therecessed guide walls cassette holder 11 form the upper part of aframe 23 of the same height as the opening in thefreezing tunnel 5. Theframe 23 is mobile onwheels 24, which means that thecassette 6 easily can be moved from thecassette holder 11 into thefreezing tunnel 5 of the freezer, and vice versa. -
FIGS. 2-4 also illustrate how the loading of thecassette 6 with flexibleliquid receptacles 25 is made. - In a first step, a number of
liquid receptacles 25 are placed in a layer on thebottom plate 12. - In a second step, the
intermediate plate 15 positioned next to thecassette 6 is lifted, guided by itsprojections 16 in therecesses 21, and is moved in between theside walls liquid receptacles 25, with itsprojections 16 inserted each into a separate one of therecesses 17. The position of eachintermediate plate 15 position transversely in relation to thebottom plate 12 is thus controlled by theside walls intermediate plate 15 lengthwise over thebottom plate 12 is controlled by the engagement of theprojections 16 with therecesses 17. Finally, the position of theintermediate plate 15 in height over thebottom plate 12 is controlled partly by the engagement of theprojections 16 with therecesses 17, and partly by spacer means in form of twoposts 26 at the opposite corners to theprojections 16. Eachintermediate plate 15 has further ahandle 27, which is positioned between theposts 26. - In a third step, a number of
liquid receptacles 25 are placed in a layer on theintermediate plate 15 placed on the liquid receptacles in the second step. - Thereafter, the second and third steps are repeated in a predetermined number of times, i.e. from zero to so many times as there are available
intermediate plates 15. Finally, anintermediate plate 15 can be placed on the top layer of theliquid receptacles 25. - As can be seen from
FIG. 5 , eachintermediate plate 15 has a number of full length ducts, which extend in the plane of theintermediate plate 15, to admit the cooling medium to flow through them and thereby cool theintermediate plate 15, when thecassette 6 is in the freezingtunnel 5. Theprojections 16 are provided each on a separate U-profile which is closely connected to a longitudinal edge of theintermediate plate 15. - Preferably, the
bottom plate 12 also has similar full length ducts. Theintermediate plate 15 is, as thebottom plate 12, preferably made of a light and good heat-transferring material, for instance aluminum or any other light metal or light metal alloy. - As indicated in
FIG. 2 , theintermediate plate 15 can along its side edge with thehandle 27 have a number ofopenings 28, more precisely onesuch opening 28 for eachliquid receptacle 25, which is intended to be placed on theintermediate plate 15. The equivalent Is also valid for thebottom plate 12. Theseopenings 28 are designed for placing test-tubes, which in some cases are annexed each to a separateliquid receptacle 25. Each test-tube contains the same blood plasma as the liquid receptacle to which it is annexed and should be placed in a vertical position during freezing. Since the height of the test-tubes may be greater then the height of theposts 26 defining the spacing between theintermediate plates 15, the test-tubes may be placed in openings alternating between the left and the right half side of theintermediate plates 15, as illustrated inFIG. 2 - In order to obtain a good heat transfer between the
intermediate plates 15 and theliquid receptacles 25, the latter preferably are so flexible as to make contact with theintermediate plates 15 over as large area as possible. - It is obvious that the invention implies that a
cassette 6 can be loaded withliquid receptacles 25 in a simple and ergonomic way, separated from the freezingtunnel 5 itself, for example at a specially for this purpose provided production station. Further, the fully loadedcassette 6 can easily be moved on thecassette holder 11 to the freezingtunnel 5 where it could be docked in order to easily be pushed into this and, after completed freezing of the liquid in theliquid receptacle 25, as easily be taken out from the freezingtunnel 5 and be placed on thecassette holder 11, which later easily can be moved to a space, where thefrozen liquid receptacles 25 are transferred to package for storing or to transport package for transfer to another place, which is provided for further storage of the liquid receptacles. Here, theliquid receptacles 25 with the frozen liquid are easily removed from thecassette 6 by raising theintermediate plates 15 one by one and then pushing each one into its sloped position in the stand 22-24 of thecassette holder 11. - For the displacement of
cassette 6 in relation to thecassette holder 11, this later has a number ofrolls 29, on which thecassette 6 is placed. Further, there is a coupling mechanism (not shown) that can keep thecassette 6 in a desired fixed position on thecassette holder 11 and also release thecassette 6 so that it can be pushed on therolls 29. - A second embodiment of a
cassette holder 30 is illustrated inFIGS. 6 and 7 as including alifting equipment 31 for raising and lowering thecassette 6 on thecassette holder 30 such that theintermediate plates 15 may be positioned at substantially the same height in theirstand 32 on thecassette holder 30. - The
lifting equipment 31 illustrated comprises atresor 33 positioned between anupper plate 34 for carrying thecassette 6 and a lower fixedsurface 35. Anelectric motor 36 is provided for driving an elevatingscrew 37 to raise or lower theupper plate 34 in accordance with instructions received from acontrol box 38. During these movements thetresor 33 keeps theupper plate 34 horizontal and parallel to the lower fixedsurface 35. - The
stand 32 has twoguide walls bottom plate 41 and aback plate 42. The twoguide walls guide walls FIGS. 2-4 but have norecesses 21 for theprojections 26 of theintermediate plates 15, since such recesses are unnecessary as the height position of thecassette 6 is adjusted by the lifting equipment. Thebottom plate 41 may be horizontal or slightly slanting backwards from thecassette 6. Theback plate 42 may be substantially vertical or slightly sloping backwards. - When starting the loading of a
cassette 6 thelifting equipment 31 holds thecassette 6 in an uppermost position. Thelifting equipment 31 then lowers thecassette 6 stepwise for eachintermediate plate 15 that is to be placed on theliquid receptacles 25 between theside walls cassette 6. When unloading theliquid receptacles 25 with frozen liquid from thecassette 6, thelifting equipment 31 first holds thecassette 6 in a lowermost position and then raises thecassette 6 stepwise for eachintermediate plate 15 that is raised from thecassette 6 and placed in thestand 32. - Consequently, the loading and unloading operations are extremely ergonomic as the
liquid receptacles 25 are being handled at substantially the same height all the time. - It will be understand that various changes and amendments of the above described embodiment may be made by those skilled in the art within the scope of the invention as expressed in the appended claims.
- In one modification, the stand of the
cassette holder 11 for placing of theintermediate plates 15 may be released from theframe 23 of the cassette holder, which means that the stand does not have to follow thecassette 6, when this is moved on thecassette holder 11 from a production station to the freezingtunnel 5. The stand could also be more or less permanently fixed to the production station. - Finally, the invention is well suited for freezing other liquids, although it is primarily meant for freezing blood plasma.
Claims (12)
1. A cassette for use in freezing a liquid contained in a plurality of liquid receptacles (25), said freezing comprising inserting the cassette (6) with the liquid receptacles (25) into a freezing tunnel (5) having a streaming cooling medium and keeping them therein until the liquid in all the liquid receptacles (25) in the cassette (6) is frozen,
comprising:
a bottom plate (12) for supporting a number of the liquid receptacles (25) in a layer,
a number of intermediate plates (15) having essentially the same dimensions as the bottom plate (12) for placing on a layer of liquid receptacles (25) and supporting a further layer of liquid receptacles (25), and
two opposite side walls (13, 14) being rigidly connected to the bottom plate (12) for constituting a U-form therewith, so that each intermediate plate (15) when placed on a layer of liquid receptacles (25) will be fixed laterally in relation to the side walls (13, 14).
2. A cassette as claimed in claim 1 , wherein each intermediate plate (15) has means (16) cooperating with the side walls (13, 14) so that each intermediate plate (15) when placed on a layer of liquid receptacles (25) will be fixed lengthwise in relation to the side walls (13, 14).
3. A cassette as claimed in claim 2 , wherein the liquid receptacles (25) are flexible and each intermediate plate (15) has spacer means (16, 26) determining the distance to the subjacent intermediate plate (15) and the bottom plate (15), respectively.
4. A cassette as claimed in claim 1 , wherein each intermediate plate (15) and the bottom plate (12) have a number of full length ducts extending in the plane of the plate for admitting the streaming of the cooling medium through them and thereby a cooling of the bottom plate (12) and the intermediate plates (15), when the cassette (6) is inserted in the freezing tunnel (5).
5. A freezer for freezing a liquid contained in a plurality of liquid receptacles (25) said freezer comprising a cassette (6) for supporting the liquid receptacles (25) and a freezing tunnel (5) for a streaming cooling medium, the cassette (6) with the liquid receptacles (25) being insertable into the freezing tunnel (5) and kept therein until the liquid in all the liquid receptacles (25) in the cassette (6) is frozen,
wherein the cassette (6) comprises a bottom plate (12) for supporting a number of liquid receptacles (25) in a layer and a number of intermediate plates (15) having substantially the same dimensions as the bottom plate (12) for being placed each on a separate layer of liquid receptacles (25) and each supporting a further layer of liquid receptacles (25),
a cassette holder (11; 30) is provided having a frame (23) for supporting the cassette (6) and a number of intermediate plates (15) separated from the cassette (6), and
the cassette holder (11; 30) is mobile for movement from a station for loading of the cassette (6) with the liquid receptacles (25) and the intermediate plates (15) to the freezing tunnel (5) for inserting the loaded cassette (6) therein.
6. A freezer as claimed in claim 5 , wherein the cassette holder (11; 30) has a stand (20-22; 32) for placing the intermediate plates (15) in a sloping or substantially vertical position in contact with each other and successively displaced in height.
7. A freezer as claimed in claim 6 , wherein the frame (23) of the cassette holder (11) is equipped with wheels (24).
8. A freezer as claimed in claim 5 , further comprising lifting equipment (31) for raising and lowering the cassette (6) on the cassette holder (30) such that the intermediate plates (15) may be loaded and unloaded at substantially the same height.
9. A freezer as claimed in claim 5 , wherein the cooling medium of the freezing tunnel (5) is air.
10. A freezer as claimed in claim 6 , wherein the stand for placing the intermediate plates (15) is releasable from the frame of the cassette holder.
11. A cassette as claimed in claim 2 , wherein each intermediate plate (15) and the bottom plate (12) have a number of full length ducts extending in the plane of the plate for admitting the streaming of the cooling medium through them and thereby a cooling of the bottom plate (12) and the intermediate plates (15), when the cassette (6) is inserted in the freezing tunnel (5).
12. A cassette as claimed in claim 3 , wherein each intermediate plate (15) and the bottom plate (12) have a number of full length ducts extending in the plane of the plate for admitting the streaming of the cooling medium through them and thereby a cooling of the bottom plate (12) and the intermediate plates (15), when the cassette (6) is inserted in the freezing tunnel (5).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0400448A SE527038C2 (en) | 2004-02-26 | 2004-02-26 | Cassette and liquid freezing apparatus |
SE0400448-7 | 2004-02-26 | ||
PCT/SE2005/000263 WO2005082317A1 (en) | 2004-02-26 | 2005-02-25 | Cassette and apparatus for liquid freezing |
Publications (1)
Publication Number | Publication Date |
---|---|
US20070157654A1 true US20070157654A1 (en) | 2007-07-12 |
Family
ID=31989614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/587,144 Abandoned US20070157654A1 (en) | 2004-02-26 | 2005-02-25 | Cassette and apparatus for liquid freezing |
Country Status (4)
Country | Link |
---|---|
US (1) | US20070157654A1 (en) |
EP (1) | EP1718262A1 (en) |
SE (1) | SE527038C2 (en) |
WO (1) | WO2005082317A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111568054A (en) * | 2020-04-05 | 2020-08-25 | 巩晓芳 | Stainless steel that box was deposited to convenient taking freezes deposits frame |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20110220A1 (en) * | 2006-08-02 | 2011-04-11 | Novartis Ag | DERIVATIVES OF 2-OXO-ETHYL-AMINO-PROPIONAMIDE-PYRROLIDIN-2-IL-SUBSTITUTED AS INHIBITORS OF THE BINDING OF THE PROTEIN Smac TO THE INHIBITOR OF THE PROTEIN OF APOPTOSIS |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3576650A (en) * | 1968-01-18 | 1971-04-27 | Union Carbide Corp | Cryogenic plastic film package |
US3797842A (en) * | 1972-06-14 | 1974-03-19 | Cornelius Co | Transfer cart |
US4203486A (en) * | 1977-01-11 | 1980-05-20 | Anchor Hocking Corporation | Food preparation apparatus and process |
US4285391A (en) * | 1979-08-29 | 1981-08-25 | Aladdin Industries, Incorporated | Electrical system for food service devices |
US4339928A (en) * | 1979-11-27 | 1982-07-20 | Raul Guibert | Freezing unit for pre-cooked food packages |
US4655466A (en) * | 1983-03-31 | 1987-04-07 | Hanaoka Sharyo Co., Ltd. | Cart |
US5927100A (en) * | 1996-02-13 | 1999-07-27 | Ingenjorsfirman Per-Oskar Persson Ab | Freezer for a liquid |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1051324A (en) * | 1900-01-01 | |||
GB922493A (en) * | 1960-04-12 | 1963-04-03 | Edwards High Vacuum Ltd | Improvements in or relating to freezedrying of foodstuffs |
FR2538364A1 (en) * | 1982-12-24 | 1984-06-29 | Frigofrance Sa | Device for handling containers in an installation for the deep-freezing of products. |
DE4206705A1 (en) * | 1992-03-04 | 1993-09-09 | Blutspendedienst Dt Rote Kreuz | Rapid deep freezing system for blood plasma sachets - has sachets on trays resting on cooling plates stacked in column and sandwiched together by piston-cylinder unit |
DE29504401U1 (en) * | 1995-03-15 | 1995-06-14 | Colora Messtechnik Gmbh | Blood plasma holder for plasma bags during freezing |
SE505988C2 (en) * | 1996-02-13 | 1997-10-27 | Ingf P O Persson Ab | Liquid freezing apparatus |
-
2004
- 2004-02-26 SE SE0400448A patent/SE527038C2/en not_active IP Right Cessation
-
2005
- 2005-02-25 EP EP05711123A patent/EP1718262A1/en not_active Withdrawn
- 2005-02-25 WO PCT/SE2005/000263 patent/WO2005082317A1/en active Application Filing
- 2005-02-25 US US10/587,144 patent/US20070157654A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3576650A (en) * | 1968-01-18 | 1971-04-27 | Union Carbide Corp | Cryogenic plastic film package |
US3797842A (en) * | 1972-06-14 | 1974-03-19 | Cornelius Co | Transfer cart |
US4203486A (en) * | 1977-01-11 | 1980-05-20 | Anchor Hocking Corporation | Food preparation apparatus and process |
US4285391A (en) * | 1979-08-29 | 1981-08-25 | Aladdin Industries, Incorporated | Electrical system for food service devices |
US4339928A (en) * | 1979-11-27 | 1982-07-20 | Raul Guibert | Freezing unit for pre-cooked food packages |
US4655466A (en) * | 1983-03-31 | 1987-04-07 | Hanaoka Sharyo Co., Ltd. | Cart |
US5927100A (en) * | 1996-02-13 | 1999-07-27 | Ingenjorsfirman Per-Oskar Persson Ab | Freezer for a liquid |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111568054A (en) * | 2020-04-05 | 2020-08-25 | 巩晓芳 | Stainless steel that box was deposited to convenient taking freezes deposits frame |
Also Published As
Publication number | Publication date |
---|---|
SE0400448D0 (en) | 2004-02-26 |
SE0400448L (en) | 2005-08-27 |
EP1718262A1 (en) | 2006-11-08 |
SE527038C2 (en) | 2005-12-13 |
WO2005082317A1 (en) | 2005-09-09 |
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