US20060229685A1 - Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) - Google Patents
Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) Download PDFInfo
- Publication number
- US20060229685A1 US20060229685A1 US11/450,202 US45020206A US2006229685A1 US 20060229685 A1 US20060229685 A1 US 20060229685A1 US 45020206 A US45020206 A US 45020206A US 2006229685 A1 US2006229685 A1 US 2006229685A1
- Authority
- US
- United States
- Prior art keywords
- small intestine
- stimulation
- patient
- duodenum
- pancreas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/321—Electromedical belts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36071—Pain
Definitions
- This invention pertains to the field of treatment of gastro-esophageal reflux disease (GERD).
- GFD gastro-esophageal reflux disease
- Gastro-esophageal reflux is a physical condition in which stomach acids reflux, or flow back from the stomach into the esophagus. Frequent reflux episodes may result in a more severe problem known as gastro-esophageal reflux disease (GERD).
- GERD gastro-esophageal reflux disease
- GERD is the most common form of dyspepsia, being present in approximately 40% of adults in the United States on an intermittent basis and some 10% on a daily basis as described in U.S. Pat. No. 6,098,629 Johnson et al., dated Aug. 8, 2000.
- dyspepsia As indicated in Johnson et al., dyspepsia, or heartburn is defined as a burning sensation or discomfort behind the breastbone or sternum and is the most common symptom of GERD.
- Other symptoms of GERD include dysphasia, odynophagia, hemorrhage, water brash and pulmonary manifestations such as asthma, coughing, or intermittent wheezing due to acid aspiration.
- GERD is generally considered to be the result of a motility disorder which permits the abnormal and prolonged exposure of the esophageal lumen to acidic gastric contents.
- Hunt “The Relationship between the Control of pH and Healing and Symptom Relief in Gastro-Oesophageal Reflux Disease”, Ailment Pharmacol Ther., 9 (Suppl. 1) pp. 3-7 (1995).
- Many factors are believed to contribute to the onset of GERD. These include transient lower esophageal sphincter (LES) relaxations, decreased LES resting tone, delayed stomach emptying and an ineffective esophageal clearance.
- LES transient lower esophageal sphincter
- Treatments for GERD include lifestyle changes such as weight loss, avoidance of certain foods (e.g., coffee, caffeine, alcohol, chocolate) that exacerbate the symptoms of GERD and avoidance of excessive bending. Elevation of the head of a patient's bed helps prevent nocturnal reflux. While these avoidance strategies may be helpful there is relatively little data pointing to the efficacy of lifestyle modification for the treatment of GERD.
- lifestyle changes such as weight loss, avoidance of certain foods (e.g., coffee, caffeine, alcohol, chocolate) that exacerbate the symptoms of GERD and avoidance of excessive bending. Elevation of the head of a patient's bed helps prevent nocturnal reflux. While these avoidance strategies may be helpful there is relatively little data pointing to the efficacy of lifestyle modification for the treatment of GERD.
- Certain medications used for treatment of GERD have been administered for years with varying success.
- Conventional antacids such as Tums® and Rolaids® may, in some patients, produce short-term relief but often have side effects including diarrhea and constipation.
- H 2 -receptor antagonists which control gastric acid secretion in the basal state
- proton pump inhibitors which control meal-stimulated acid secretion
- Surgery treatments are also known for the treatment of GERD and include techniques for bulking the lower esophageal sphincter such as techniques described in U.S. Pat. No. 6,098,629 Johnson et al, Aug. 8, 2000.
- Other surgical techniques include placement of pacemakers for stimulating muscle contractions in the esophageal sphincter, the stomach muscles or in the pyloric valve.
- U.S. Pat. No. 6,104,955 to Bourgeois U.S. Pat. No. 5,861,014 to Familoni.
- GERD GERD continues to be a serious disease proving to be difficult to treat by any of the foregoing prior art techniques.
- One inventive aspect of the present disclosure relates to methods and devices for treating GERD by stimulating the duodenum of a patient to accelerate gastric emptying.
- a method and apparatus for treating gastro-esophageal reflux disease of a patient.
- the method includes stimulating a body organ to accelerate a discharge of contents from a duodenum of a patient to thereby encourage discharge of contents from a stomach of the patient across a pyloric valve of the patient and into the duodenum.
- the apparatus of the invention includes a signal generator for generating a stimulation signal.
- a conductor electrically connects the signal generator to the body organ to accelerate a discharge of contents from the duodenum of the patient to encourage gastric emptying.
- FIG. 1 is a schematic representation of a gastric-emptying feedback loop with a patient-controlled stimulator for stimulating an organ of the loop;
- FIG. 2 is a view similar to FIG. 1 with an automatic controller replacing the patient-controller of FIG. 1 and with feedback circuits to the automatic controller schematically represented.
- a gastric emptying feedback loop is shown schematically for ease of illustration.
- the feedback loop illustrates a patient's stomach S which is provided with food from the esophagus E.
- a lower esophageal sphincter LES is shown positioned between the esophagus E and the stomach S.
- the lower esophageal sphincter normally provides control of reflux of stomach contents into the esophagus E.
- the stomach discharges into the superior duodenum D which is an upper portion of the intestines.
- the superior duodenum D and the stomach S are separated by a pyloric valve PV which opens to permit gastric emptying from the stomach into the duodenum D.
- nerve paths N providing signal flow paths from both the superior duodenum D and the stomach S to the brain B.
- An efferent Vagal nerve VN connects the brain B to the pancreas P of the patient.
- a conduit pancreatic duct PD extends from the pancreas P and discharges into the superior duodenum D.
- the presence of food contents within the duodenum D may prevent passage of gastric content of the stomach S past the pyloric valve PV into the duodenum D.
- contents can be forced retrograde past the lower esophageal sphincter LES and into the esophagus E creating the symptoms and discomfort of GERD.
- the contents discharging from the stomach S into the duodenum D are acidic (and high osmolality) and reside in the duodenum D until pH is elevated (close to a neutral pH of 6-7) and osmolality is normalized.
- the elevation of pH and reduction of osmolality of chyme in the duodenum D results from exocrine secretion being administered from the pancreas P and from bile from the liver into the duodenum D. This raises the pH and lowers the osmolality of the duodenum D content permitting discharge from the duodenum D and thereby permitting gastric emptying across the pyloric valve PV.
- gastro-esophageal reflux disease results from a derangement of the feedback loops involved in upper GI digestion and motility control.
- This problem encompasses receptors and reflexes that regulate the propulsive contractions of the stomach, upper duodenum and biliary tree and the secretions of the exocrine pancreas.
- the interaction of these receptors and reflexes control gastric emptying (by coordinating gastric propulsive contractions and sphincter [primarily pyloric] tone) and regulate the pH and osmolality of the chyme in the duodenum.
- ingestate delivered to the stomach is mixed by low intensity gastric mixing contractions with the enzymatic, ionic, including hydrogen ion (H + ), and water secretions of the glands of the stomach.
- H + hydrogen ion
- the fluid now called chyme
- This material is at a very low pH (about 2) and high osmolality, which activates receptors, including those for H + and osmotic pressure, which are abundant in the wall of the ampulla.
- This receptor activation initiates the series of reflexes that cause pancreatic exocrine secretion to be delivered into the superior duodenum and ampulla.
- This fluid contains digestive enzymes, water and buffering compounds to raise the pH, and reduce the osmolality, of the chyme.
- control system If the control system is down regulated by, for example, by increased pH of gastric contents entering the ampulla, feedback may thereby be reduced from the H + receptors in the duodenum that stimulate pancreatic exocrine secretion and bile delivery to the duodenum, then movement of chyme from the superior duodenum is delayed, causing delay of gastric emptying.
- the drugs used to treat this disease raise pH further dampening the hydrogen-receptor-pancreatic secretion loop, further delaying gastric emptying.
- Benini “Gastric Emptying and Dyspeptic Symptoms in Patients with Gastroesophageal Reflux”, Amer. J. of Gastroenterology, pp. 1351-1354 (1996).
- the present invention is directed towards reestablishing the link between gastric emptying and pancreatic secretion delivery, thereby addressing the main pathology of this disease by shortening chyme residence time in the superior duodenum so that intestinal contents move into the distal digestive tract in a more normal manner.
- this is done by stimulating the H+ ion receptors or by stimulation of the pancreas directly or via its para-sympathetic innervation (pre-ganglionic Vagal nerves). Stimulation of pancreatic exocrine secretion has been shown by direct stimulation of the thoracic vagus nerves in dogs.
- Acidity can be assessed by measuring bicarbonate. It will be understood that references to ⁇ H includes such indirect measurements. Also, effects of the therapy described herein can be assessed and/or controlled by measuring an indication of pancreatic exocrine secretion or bile (e.g., HCO 3 ⁇ ).
- An alternative embodiment uses gastrocopic delivery of a paralyzing agent (e.g. botulism toxin) to the pyloric valve along with use of H 2 antagonists or PPI's to manage the acidity of the chyme reaching the duodenum.
- a paralyzing agent e.g. botulism toxin
- the gall bladder can be stimulated to encourage bile movement into the duodenum.
- the gall bladder GB resides below the liver L.
- the gall bladder is connected to the small intestine (specifically the duodenum D) via a bile duct BD.
- the bile duct BD can discharge directly into the duodenum D or via the pancreatic duct PD as shown.
- the bile can normalize the chyme to accelerate duodenal emptying.
- Bile consists of bile acids (detergents that emulsify lipids), cholesterol, phospholipids, electrolytes such as (Na + , K + , Ca +2 , Cl ⁇ , HCO 3 ⁇ ) and H 2 O. Chapter 4, “The Liver and Biliary Tract”, Gastrointestinal System, 2 nd Ed., M. S. Long editor, Mosby Publisher, London (2002).
- the gall bladder GB or bile duct can be stimulated indirectly via stimulation of the vagal nerve VN or directly stimulated by an electrode or other stimulator.
- an electrical stimulator 10 , 20 which may be implanted is provided which alternatively may be directly connected to the Vagal nerve VN (e.g., via stimulation pathway 13 ) or the pancreas P (e.g., via stimulation pathway 11 shown in dashed line) to stimulate the pancreas directly or indirectly to excrete exocrine into the duodenum D (or more distally into the small intestine—e.g., into the jejunum) and increase the pH of chyme in the duodenum D as described.
- VN Vagal nerve
- the pancreas P e.g., via stimulation pathway 11 shown in dashed line
- the same can be done to promote bile release by stimulating the bile duct BD or the gall bladder GB either directly (e.g., via stimulation pathway 11 ) or indirectly (e.g., by stimulating Vagal nerve VN via stimulation pathway 13 ).
- the duodenum D can be stimulated directly (e.g., via one or more electrodes or other stimulators as indicated by pathway 11 ) to cause propulsive contractions that accelerate duodenum emptying.
- the frequency may be varied to maximize the response and selectively stimulate exocrine instead of endocrine secretions.
- the patient may activate the stimulator 10 by remote transmitter to stimulate an electrical charge either after eating (e.g., about 60 to 90 minutes after eating) or on onset of GERD symptoms.
- an electrical charge either after eating (e.g., about 60 to 90 minutes after eating) or on onset of GERD symptoms.
- nerve stimulators and organ stimulators available for implantation and are commercially available and which include connectors for connecting directly to nerves.
- FIG. 2 illustrates an additional embodiment where the patient activated loop is replaced with an automatic loop having a programmable stimulator 20 which receives as an input signals from sensors in the duodenum to measure pH, osmolality or strain (e.g., from baro-sensors) on the duodenum indicating filling or may measure acidity in the esophagus or strain on the lower esophageal sphincter LES or stomach S all of which may be provided to the implantable controller 20 which can be provided with desirable software to process the incoming signals and generate a stimulating signal to either the Vagal nerve, the pancreas P, the gall bladder GB, the bile duct BD or the duodenum D (or jejunum) directly in response to such received signals.
- a programmable stimulator 20 which receives as an input signals from sensors in the duodenum to measure pH, osmolality or strain (e.g., from baro-sensors) on the duodenum indicating filling or may measure
Abstract
GERD is treated through a method and apparatus of stimulating the body organ to accelerate a discharge of contents from the duodenum of the patient to thereby encourage discharge of contents from the stomach of the patient across the pyloric valve and into the duodenum.
Description
- This application is a divisional of application Ser. No. 10/358,093, filed Feb. 3, 2003, which application is incorporated herein by reference.
- 1. Field of the Invention
- This invention pertains to the field of treatment of gastro-esophageal reflux disease (GERD).
- 2. Description of the Prior Art
- Gastro-esophageal reflux is a physical condition in which stomach acids reflux, or flow back from the stomach into the esophagus. Frequent reflux episodes may result in a more severe problem known as gastro-esophageal reflux disease (GERD). GERD is the most common form of dyspepsia, being present in approximately 40% of adults in the United States on an intermittent basis and some 10% on a daily basis as described in U.S. Pat. No. 6,098,629 Johnson et al., dated Aug. 8, 2000.
- As indicated in Johnson et al., dyspepsia, or heartburn is defined as a burning sensation or discomfort behind the breastbone or sternum and is the most common symptom of GERD. Other symptoms of GERD include dysphasia, odynophagia, hemorrhage, water brash and pulmonary manifestations such as asthma, coughing, or intermittent wheezing due to acid aspiration.
- GERD is generally considered to be the result of a motility disorder which permits the abnormal and prolonged exposure of the esophageal lumen to acidic gastric contents. Hunt, “The Relationship between the Control of pH and Healing and Symptom Relief in Gastro-Oesophageal Reflux Disease”, Ailment Pharmacol Ther., 9 (Suppl. 1) pp. 3-7 (1995). Many factors are believed to contribute to the onset of GERD. These include transient lower esophageal sphincter (LES) relaxations, decreased LES resting tone, delayed stomach emptying and an ineffective esophageal clearance.
- Treatments for GERD include lifestyle changes such as weight loss, avoidance of certain foods (e.g., coffee, caffeine, alcohol, chocolate) that exacerbate the symptoms of GERD and avoidance of excessive bending. Elevation of the head of a patient's bed helps prevent nocturnal reflux. While these avoidance strategies may be helpful there is relatively little data pointing to the efficacy of lifestyle modification for the treatment of GERD.
- Certain medications used for treatment of GERD have been administered for years with varying success. Conventional antacids such as Tums® and Rolaids® may, in some patients, produce short-term relief but often have side effects including diarrhea and constipation.
- Other drugs have been more effective at controlling GERD but fail to treat underlying causes of the disease and have been proven to be extremely expensive and not readily available to all patients due to such expense. Examples of such drugs are H2-receptor antagonists (which control gastric acid secretion in the basal state) and proton pump inhibitors (which control meal-stimulated acid secretion). Hunt, id. Both classes of drugs can raise intragastric pH to or about 4 for varying durations. Hunt, supra.
- Surgery treatments are also known for the treatment of GERD and include techniques for bulking the lower esophageal sphincter such as techniques described in U.S. Pat. No. 6,098,629 Johnson et al, Aug. 8, 2000. Other surgical techniques include placement of pacemakers for stimulating muscle contractions in the esophageal sphincter, the stomach muscles or in the pyloric valve. U.S. Pat. No. 6,104,955 to Bourgeois, U.S. Pat. No. 5,861,014 to Familoni.
- A summary of GERD treatments can be found in DeVault, et al., “Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease”, Amer. J. of Gastroenterology, Vol. 94, No. 6, pp. 1434-1442 (1999).
- Notwithstanding multiple attempts at various types of treatment, GERD continues to be a serious disease proving to be difficult to treat by any of the foregoing prior art techniques. In view of the foregoing and notwithstanding various efforts exemplified in the prior art, there remains a need for an effective treatment for GERD. It is an object of the present invention to provide a novel treatment and novel apparatus for the treatment of GERD.
- One inventive aspect of the present disclosure relates to methods and devices for treating GERD by stimulating the duodenum of a patient to accelerate gastric emptying.
- According to a preferred embodiment of the present invention, a method and apparatus are disclosed for treating gastro-esophageal reflux disease of a patient. The method includes stimulating a body organ to accelerate a discharge of contents from a duodenum of a patient to thereby encourage discharge of contents from a stomach of the patient across a pyloric valve of the patient and into the duodenum. The apparatus of the invention includes a signal generator for generating a stimulation signal. A conductor electrically connects the signal generator to the body organ to accelerate a discharge of contents from the duodenum of the patient to encourage gastric emptying.
-
FIG. 1 is a schematic representation of a gastric-emptying feedback loop with a patient-controlled stimulator for stimulating an organ of the loop; and -
FIG. 2 is a view similar toFIG. 1 with an automatic controller replacing the patient-controller ofFIG. 1 and with feedback circuits to the automatic controller schematically represented. - With reference now to the various drawing figures in which identical elements are numbered identically throughout, a description of the preferred embodiment of the present invention will now be described.
- With initial reference to
FIG. 1 , a gastric emptying feedback loop is shown schematically for ease of illustration. The feedback loop illustrates a patient's stomach S which is provided with food from the esophagus E. A lower esophageal sphincter LES is shown positioned between the esophagus E and the stomach S. The lower esophageal sphincter normally provides control of reflux of stomach contents into the esophagus E. - On a proximal or lower end of the stomach S the stomach discharges into the superior duodenum D which is an upper portion of the intestines. The superior duodenum D and the stomach S are separated by a pyloric valve PV which opens to permit gastric emptying from the stomach into the duodenum D.
- Also schematically illustrated in
FIG. 1 are nerve paths N providing signal flow paths from both the superior duodenum D and the stomach S to the brain B. An efferent Vagal nerve VN connects the brain B to the pancreas P of the patient. A conduit (pancreatic duct PD) extends from the pancreas P and discharges into the superior duodenum D. - The presence of food contents within the duodenum D (such contents being referred to as “chyme”) may prevent passage of gastric content of the stomach S past the pyloric valve PV into the duodenum D. As long as such gastric contents cannot be passed into the duodenum D, such contents can be forced retrograde past the lower esophageal sphincter LES and into the esophagus E creating the symptoms and discomfort of GERD. The contents discharging from the stomach S into the duodenum D are acidic (and high osmolality) and reside in the duodenum D until pH is elevated (close to a neutral pH of 6-7) and osmolality is normalized.
- The elevation of pH and reduction of osmolality of chyme in the duodenum D results from exocrine secretion being administered from the pancreas P and from bile from the liver into the duodenum D. This raises the pH and lowers the osmolality of the duodenum D content permitting discharge from the duodenum D and thereby permitting gastric emptying across the pyloric valve PV.
- According to the present invention, gastro-esophageal reflux disease (GERD) results from a derangement of the feedback loops involved in upper GI digestion and motility control. This problem encompasses receptors and reflexes that regulate the propulsive contractions of the stomach, upper duodenum and biliary tree and the secretions of the exocrine pancreas. The interaction of these receptors and reflexes control gastric emptying (by coordinating gastric propulsive contractions and sphincter [primarily pyloric] tone) and regulate the pH and osmolality of the chyme in the duodenum. This chemo-regulation is mediated through control of bile delivery and stimulation of secretion by the exocrine pancreas of fluid delivered to the superior duodenum. Chey et al., “Neural Hormonal Regulation of Exocrine Pancreatic Secretion”, Pancreatology, pp. 320-335 (2001).
- Normally, ingestate delivered to the stomach is mixed by low intensity gastric mixing contractions with the enzymatic, ionic, including hydrogen ion (H+), and water secretions of the glands of the stomach. When the material is adequately reduced in size and is a smooth consistency, the fluid, now called chyme, is delivered to the ampulla of the small intestine by the much stronger propulsive, or emptying, contractions of the stomach coupled with transitory relaxation of the pyloric sphincter. This material is at a very low pH (about 2) and high osmolality, which activates receptors, including those for H+ and osmotic pressure, which are abundant in the wall of the ampulla. This receptor activation initiates the series of reflexes that cause pancreatic exocrine secretion to be delivered into the superior duodenum and ampulla. This fluid contains digestive enzymes, water and buffering compounds to raise the pH, and reduce the osmolality, of the chyme.
- Once a neutral pH and physiological osmolality are achieved, then propulsive contractions in the superior duodenum move the chyme out of the superior portion into the length of the duodenum; At which point the stretch and baro-receptors in the ampulla allow the pyloric sphincter to relax and another bolus of gastric contents is delivered into the ampulla by the peristaltic gastric emptying contractions. This material, at a very low pH (less than 2), activates hydrogen ion (H+) on receptors of the ampulla (upper most portion of the duodenum) causing the pancreatic fluids to be delivered to the material in the ampulla restarting the cycle as described above. Chapter 3, “The Stomach”, Gastrointestinal System, 2nd Ed., M. S. Long editor, Mosby Publisher, London (2002).
- If the control system is down regulated by, for example, by increased pH of gastric contents entering the ampulla, feedback may thereby be reduced from the H+ receptors in the duodenum that stimulate pancreatic exocrine secretion and bile delivery to the duodenum, then movement of chyme from the superior duodenum is delayed, causing delay of gastric emptying. Mabayo, et al., “Inhibition of Food Passage by Osmeprazole in the Chicken”, European J. of Pharmacology, pp. 161-165 (1995).
- In GERD, this reflex is inhibited in such a way that the stomach empties more slowly so that the gastric emptying contractions force gastric contents to flow retrograde into the esophagus. This is a result of the situation in which the gastric emptying contractions are vigorous but must operate against a contracted pyloric sphincter. These vigorous peristaltic contractions eventually begin to force gastric contents to flow retrograde into the esophagus because of the inherent imbalance between a very strong pyloric sphincter and a much weaker gastro-esophageal sphincter. The delay in gastric emptying is directly related to a slow down in the transport of chyme out of the ampulla and superior duodenum. The drugs used to treat this disease raise pH further dampening the hydrogen-receptor-pancreatic secretion loop, further delaying gastric emptying. Benini, “Gastric Emptying and Dyspeptic Symptoms in Patients with Gastroesophageal Reflux”, Amer. J. of Gastroenterology, pp. 1351-1354 (1996).
- The present invention is directed towards reestablishing the link between gastric emptying and pancreatic secretion delivery, thereby addressing the main pathology of this disease by shortening chyme residence time in the superior duodenum so that intestinal contents move into the distal digestive tract in a more normal manner. According to a first embodiment, this is done by stimulating the H+ ion receptors or by stimulation of the pancreas directly or via its para-sympathetic innervation (pre-ganglionic Vagal nerves). Stimulation of pancreatic exocrine secretion has been shown by direct stimulation of the thoracic vagus nerves in dogs. Kaminski et al., “The Effect of Electrical Vagal Stimulation on Canine Pancreatic Exocrine Function”, Surgery, pp. 545-552 (1975). This results in a more rapid (normal) neutralization of chyme in the ampulla, allowing it move down the duodenum more quickly so that gastric emptying is returned to a more normal pace.
- Acidity (pH) can be assessed by measuring bicarbonate. It will be understood that references to −H includes such indirect measurements. Also, effects of the therapy described herein can be assessed and/or controlled by measuring an indication of pancreatic exocrine secretion or bile (e.g., HCO3 −).
- An alternative embodiment uses gastrocopic delivery of a paralyzing agent (e.g. botulism toxin) to the pyloric valve along with use of H2 antagonists or PPI's to manage the acidity of the chyme reaching the duodenum.
- As an additional alternative to pancreatic stimulation, the gall bladder can be stimulated to encourage bile movement into the duodenum. Shown schematically in the figures, the gall bladder GB resides below the liver L. The gall bladder is connected to the small intestine (specifically the duodenum D) via a bile duct BD. The bile duct BD can discharge directly into the duodenum D or via the pancreatic duct PD as shown. The bile can normalize the chyme to accelerate duodenal emptying. Bile consists of bile acids (detergents that emulsify lipids), cholesterol, phospholipids, electrolytes such as (Na+, K+, Ca+2, Cl−, HCO3 −) and H2O. Chapter 4, “The Liver and Biliary Tract”, Gastrointestinal System, 2nd Ed., M. S. Long editor, Mosby Publisher, London (2002). The gall bladder GB or bile duct can be stimulated indirectly via stimulation of the vagal nerve VN or directly stimulated by an electrode or other stimulator.
- As illustrated in the figures, an
electrical stimulator - With a patient control stimulation as shown in
FIG. 1 , the patient may activate thestimulator 10 by remote transmitter to stimulate an electrical charge either after eating (e.g., about 60 to 90 minutes after eating) or on onset of GERD symptoms. It will be appreciated that there are a wide variety of nerve stimulators and organ stimulators available for implantation and are commercially available and which include connectors for connecting directly to nerves. -
FIG. 2 illustrates an additional embodiment where the patient activated loop is replaced with an automatic loop having aprogrammable stimulator 20 which receives as an input signals from sensors in the duodenum to measure pH, osmolality or strain (e.g., from baro-sensors) on the duodenum indicating filling or may measure acidity in the esophagus or strain on the lower esophageal sphincter LES or stomach S all of which may be provided to theimplantable controller 20 which can be provided with desirable software to process the incoming signals and generate a stimulating signal to either the Vagal nerve, the pancreas P, the gall bladder GB, the bile duct BD or the duodenum D (or jejunum) directly in response to such received signals. It will be appreciated that stimulators and controllers are well within the skill of the art. U.S. Pat. No. 5,540,730, which is hereby incorporated by reference in its entirety, teaches a neurostimulator to stimulate a vagus nerve to treat a motility disorder. U.S. Pat. No. 5,292,344, which is hereby incorporated by reference in its entirety, teaches gastrointestinal sensors including pH sensors. - With the foregoing detailed description of the present invention, it has been shown how the objects of the invention have been attained in a preferred manner. Modifications and equivalents of disclosed concepts such as those which might readily occur to one skilled in the art, are intended to be included in the scope of the claims which are appended hereto.
Claims (20)
1. A method for treating gastro-esophageal reflux disease (GERD) of a patient comprising:
treating a body organ to accelerate a discharge of contents through at least a portion of a small intestine of the patient to thereby encourage discharge of contents from a stomach of the patient across a pyloric valve of the patient and into said small intestine.
2. A method according to claim 1 wherein said portion is a duodenum of said patient.
3. A method according to claim 1 wherein said treating is a stimulation selected to increase a pH of said contents of said portion of said small intestine.
4. A method according to claim 1 wherein said treating is a stimulation selected to decrease an osmolality of said contents of said portion of said small intestine.
5. A method according to claim 1 wherein said organ is a pancreas of said patient and said treating is a stimulation of said organ selected to stimulate delivery of an exocrine secretion from said pancreas to said portion of said small intestine.
6. A method according to claim 5 wherein said pancreas is stimulated directly.
7. A method according to claim 5 wherein said pancreas is indirectly stimulated by stimulating at least a nerve of said pancreas.
8. A method according to claim 5 wherein said stimulation is initiated by said patient.
9. A method according to claim 5 wherein said stimulation is initiated by a controller operatively connected to stimulating electrodes and having an input operatively connected to a sensor.
10. A method according to claim 9 wherein said sensor senses a pH level of said portion of said small intestine.
11. A method according to claim 9 wherein said sensor senses a degree of filling of said portion of said small intestine.
12. A method according to claim 9 wherein said sensor senses a degree of osmolality within said portion of said small intestine.
13. A method according to claim 9 wherein said sensor senses a degree of motility within said portion of said small intestine.
14. A method according to claim 1 wherein said treatment includes delivery of a paralyzing agent to said pyloric valve.
15. A method according to claim 14 wherein said delivery is done in conjunction with agents to manage acidity of a content of said portion of said small intestine.
16. A method according to claim 15 wherein said agents are selected from a group including H2 antagonists and PPI's.
17. A method according to claim 5 wherein said stimulation is an electrical stimulation.
18. A method according to claim 17 wherein said stimulation is at a frequency selected to encourage exocrine secretion without excess endocrine secretion.
19. A method according to claim 1 wherein said treating is a stimulation selected to encourage bile delivery to the portion of said small intestine.
20. A method according to claim 1 , wherein the body organ is a duodenum of said patient.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/450,202 US20060229685A1 (en) | 2003-02-03 | 2006-06-09 | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/358,093 US20040172084A1 (en) | 2003-02-03 | 2003-02-03 | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
US11/450,202 US20060229685A1 (en) | 2003-02-03 | 2006-06-09 | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/358,093 Division US20040172084A1 (en) | 2003-02-03 | 2003-02-03 | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
Publications (1)
Publication Number | Publication Date |
---|---|
US20060229685A1 true US20060229685A1 (en) | 2006-10-12 |
Family
ID=32907599
Family Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/358,093 Abandoned US20040172084A1 (en) | 2003-02-03 | 2003-02-03 | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
US10/675,818 Abandoned US20040176812A1 (en) | 2003-02-03 | 2003-09-29 | Enteric rhythm management |
US10/674,330 Expired - Fee Related US7489969B2 (en) | 2003-02-03 | 2003-09-29 | Vagal down-regulation obesity treatment |
US10/674,324 Abandoned US20040172085A1 (en) | 2003-02-03 | 2003-09-29 | Nerve stimulation and conduction block therapy |
US11/450,202 Abandoned US20060229685A1 (en) | 2003-02-03 | 2006-06-09 | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
US11/891,770 Expired - Lifetime US7729771B2 (en) | 2003-02-03 | 2007-08-13 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US12/721,603 Expired - Fee Related US8010204B2 (en) | 2003-02-03 | 2010-03-11 | Nerve blocking for treatment of gastrointestinal disorders |
US13/188,293 Expired - Fee Related US8538542B2 (en) | 2003-02-03 | 2011-07-21 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US14/019,126 Expired - Fee Related US9174040B2 (en) | 2003-02-03 | 2013-09-05 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US14/930,233 Expired - Fee Related US9682233B2 (en) | 2003-02-03 | 2015-11-02 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US15/625,755 Abandoned US20170304615A1 (en) | 2003-02-03 | 2017-06-16 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/358,093 Abandoned US20040172084A1 (en) | 2003-02-03 | 2003-02-03 | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
US10/675,818 Abandoned US20040176812A1 (en) | 2003-02-03 | 2003-09-29 | Enteric rhythm management |
US10/674,330 Expired - Fee Related US7489969B2 (en) | 2003-02-03 | 2003-09-29 | Vagal down-regulation obesity treatment |
US10/674,324 Abandoned US20040172085A1 (en) | 2003-02-03 | 2003-09-29 | Nerve stimulation and conduction block therapy |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/891,770 Expired - Lifetime US7729771B2 (en) | 2003-02-03 | 2007-08-13 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US12/721,603 Expired - Fee Related US8010204B2 (en) | 2003-02-03 | 2010-03-11 | Nerve blocking for treatment of gastrointestinal disorders |
US13/188,293 Expired - Fee Related US8538542B2 (en) | 2003-02-03 | 2011-07-21 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US14/019,126 Expired - Fee Related US9174040B2 (en) | 2003-02-03 | 2013-09-05 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US14/930,233 Expired - Fee Related US9682233B2 (en) | 2003-02-03 | 2015-11-02 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US15/625,755 Abandoned US20170304615A1 (en) | 2003-02-03 | 2017-06-16 | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
Country Status (5)
Country | Link |
---|---|
US (11) | US20040172084A1 (en) |
EP (1) | EP2366425A1 (en) |
AT (2) | ATE547148T1 (en) |
AU (1) | AU2009245845B2 (en) |
DK (1) | DK1601414T3 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080281365A1 (en) * | 2007-05-09 | 2008-11-13 | Tweden Katherine S | Neural signal duty cycle |
US20090210019A1 (en) * | 2008-02-14 | 2009-08-20 | Dennis Dong-Won Kim | Treatment of excess weight by neural downregulation in combination with compositions |
US20090254143A1 (en) * | 2008-04-04 | 2009-10-08 | Tweden Katherine S | Methods and systems for glucose regulation |
US7672727B2 (en) | 2005-08-17 | 2010-03-02 | Enteromedics Inc. | Neural electrode treatment |
US7693577B2 (en) | 2003-02-03 | 2010-04-06 | Enteromedics Inc. | Irritable bowel syndrome treatment |
US7729771B2 (en) | 2003-02-03 | 2010-06-01 | Enteromedics Inc. | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
US7844338B2 (en) | 2003-02-03 | 2010-11-30 | Enteromedics Inc. | High frequency obesity treatment |
US8825164B2 (en) | 2010-06-11 | 2014-09-02 | Enteromedics Inc. | Neural modulation devices and methods |
US11413296B2 (en) | 2005-11-12 | 2022-08-16 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
Families Citing this family (269)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7076307B2 (en) * | 2002-05-09 | 2006-07-11 | Boveja Birinder R | Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders |
US6587719B1 (en) * | 1999-07-01 | 2003-07-01 | Cyberonics, Inc. | Treatment of obesity by bilateral vagus nerve stimulation |
US20070203531A9 (en) * | 1999-12-03 | 2007-08-30 | Medtronic, Inc. | Heart rate variability control of gastric electrical stimulator |
US20060085046A1 (en) * | 2000-01-20 | 2006-04-20 | Ali Rezai | Methods of treating medical conditions by transvascular neuromodulation of the autonomic nervous system |
US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
AU6634501A (en) * | 2000-06-30 | 2002-01-14 | Sumitomo Pharma | Five-membered-ring compound |
US6609025B2 (en) * | 2001-01-02 | 2003-08-19 | Cyberonics, Inc. | Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation |
US7756582B2 (en) | 2001-05-01 | 2010-07-13 | Intrapace, Inc. | Gastric stimulation anchor and method |
US7747322B2 (en) | 2001-05-01 | 2010-06-29 | Intrapace, Inc. | Digestive organ retention device |
US7979127B2 (en) | 2001-05-01 | 2011-07-12 | Intrapace, Inc. | Digestive organ retention device |
US7689284B2 (en) | 2001-05-01 | 2010-03-30 | Intrapace, Inc. | Pseudounipolar lead for stimulating a digestive organ |
US7616996B2 (en) | 2005-09-01 | 2009-11-10 | Intrapace, Inc. | Randomized stimulation of a gastrointestinal organ |
US7702394B2 (en) | 2001-05-01 | 2010-04-20 | Intrapace, Inc. | Responsive gastric stimulator |
US20080077192A1 (en) | 2002-05-03 | 2008-03-27 | Afferent Corporation | System and method for neuro-stimulation |
US7837719B2 (en) | 2002-05-09 | 2010-11-23 | Daemen College | Electrical stimulation unit and waterbath system |
AU2004212004B2 (en) | 2003-02-13 | 2008-01-10 | Albert Einstein College Of Medicine Of Yeshiva University | Regulation of food intake and glucose production by modulation of long-chain fatty acyl-coa levels in the hypothalamus |
US7684865B2 (en) * | 2003-03-14 | 2010-03-23 | Endovx, Inc. | Methods and apparatus for treatment of obesity |
US20040226556A1 (en) | 2003-05-13 | 2004-11-18 | Deem Mark E. | Apparatus for treating asthma using neurotoxin |
US20050070970A1 (en) * | 2003-09-29 | 2005-03-31 | Knudson Mark B. | Movement disorder stimulation with neural block |
US20050070974A1 (en) * | 2003-09-29 | 2005-03-31 | Knudson Mark B. | Obesity and eating disorder stimulation treatment with neural block |
US7054690B2 (en) | 2003-10-22 | 2006-05-30 | Intrapace, Inc. | Gastrointestinal stimulation device |
US9050469B1 (en) | 2003-11-26 | 2015-06-09 | Flint Hills Scientific, Llc | Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals |
US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
AU2005225458B2 (en) | 2004-03-25 | 2008-12-04 | The Feinstein Institutes For Medical Research | Neural tourniquet |
EP1750799A2 (en) * | 2004-05-04 | 2007-02-14 | The Cleveland Clinic Foundation | Methods of treating medical conditions by neuromodulation of the sympathetic nervous system |
US7803195B2 (en) * | 2004-06-03 | 2010-09-28 | Mayo Foundation For Medical Education And Research | Obesity treatment and device |
US7664551B2 (en) * | 2004-07-07 | 2010-02-16 | Medtronic Transneuronix, Inc. | Treatment of the autonomic nervous system |
US20060020298A1 (en) * | 2004-07-20 | 2006-01-26 | Camilleri Michael L | Systems and methods for curbing appetite |
US20060020277A1 (en) * | 2004-07-20 | 2006-01-26 | Gostout Christopher J | Gastric reshaping devices and methods |
US8452407B2 (en) * | 2004-08-16 | 2013-05-28 | Boston Scientific Neuromodulation Corporation | Methods for treating gastrointestinal disorders |
US20060070334A1 (en) * | 2004-09-27 | 2006-04-06 | Blue Hen, Llc | Sidewall plank for constructing a trailer and associated trailer sidewall construction |
US7833279B2 (en) * | 2004-11-12 | 2010-11-16 | Enteromedics Inc. | Pancreatic exocrine secretion diversion apparatus and method |
AU2005323463B2 (en) | 2004-12-27 | 2009-11-19 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by electrical vagus nerve stimulation |
US11207518B2 (en) | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
US8600521B2 (en) | 2005-01-27 | 2013-12-03 | Cyberonics, Inc. | Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity |
US8565867B2 (en) | 2005-01-28 | 2013-10-22 | Cyberonics, Inc. | Changeable electrode polarity stimulation by an implantable medical device |
US7454245B2 (en) * | 2005-01-28 | 2008-11-18 | Cyberonics, Inc. | Trained and adaptive response in a neurostimulator |
US9314633B2 (en) | 2008-01-25 | 2016-04-19 | Cyberonics, Inc. | Contingent cardio-protection for epilepsy patients |
US7561918B2 (en) * | 2005-01-28 | 2009-07-14 | Cyberonics, Inc. | Autocapture in a neurostimulator |
US8371307B2 (en) | 2005-02-08 | 2013-02-12 | Koninklijke Philips Electronics N.V. | Methods and devices for the treatment of airway obstruction, sleep apnea and snoring |
US8096303B2 (en) | 2005-02-08 | 2012-01-17 | Koninklijke Philips Electronics N.V | Airway implants and methods and devices for insertion and retrieval |
US8700163B2 (en) * | 2005-03-04 | 2014-04-15 | Cyberonics, Inc. | Cranial nerve stimulation for treatment of substance addiction |
US7310557B2 (en) * | 2005-04-29 | 2007-12-18 | Maschino Steven E | Identification of electrodes for nerve stimulation in the treatment of eating disorders |
US7835796B2 (en) * | 2005-04-29 | 2010-11-16 | Cyberonics, Inc. | Weight loss method and device |
US7899540B2 (en) * | 2005-04-29 | 2011-03-01 | Cyberonics, Inc. | Noninvasively adjustable gastric band |
US20070016262A1 (en) * | 2005-07-13 | 2007-01-18 | Betastim, Ltd. | Gi and pancreatic device for treating obesity and diabetes |
WO2007013065A2 (en) | 2005-07-25 | 2007-02-01 | Rainbow Medical Ltd. | Electrical stimulation of blood vessels |
US20070027504A1 (en) * | 2005-07-27 | 2007-02-01 | Cyberonics, Inc. | Cranial nerve stimulation to treat a hearing disorder |
US7840280B2 (en) | 2005-07-27 | 2010-11-23 | Cyberonics, Inc. | Cranial nerve stimulation to treat a vocal cord disorder |
US7706874B2 (en) | 2005-07-28 | 2010-04-27 | Cyberonics, Inc. | Stimulating cranial nerve to treat disorders associated with the thyroid gland |
US8660647B2 (en) | 2005-07-28 | 2014-02-25 | Cyberonics, Inc. | Stimulating cranial nerve to treat pulmonary disorder |
US7856273B2 (en) * | 2005-07-28 | 2010-12-21 | Cyberonics, Inc. | Autonomic nerve stimulation to treat a gastrointestinal disorder |
US20070027484A1 (en) * | 2005-07-28 | 2007-02-01 | Cyberonics, Inc. | Autonomic nerve stimulation to treat a pancreatic disorder |
US7822486B2 (en) | 2005-08-17 | 2010-10-26 | Enteromedics Inc. | Custom sized neural electrodes |
US20070073354A1 (en) | 2005-09-26 | 2007-03-29 | Knudson Mark B | Neural blocking therapy |
US7957796B2 (en) | 2005-10-28 | 2011-06-07 | Cyberonics, Inc. | Using physiological sensor data with an implantable medical device |
US8041428B2 (en) | 2006-02-10 | 2011-10-18 | Electrocore Llc | Electrical stimulation treatment of hypotension |
US8676324B2 (en) | 2005-11-10 | 2014-03-18 | ElectroCore, LLC | Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders |
US10537728B2 (en) | 2005-11-10 | 2020-01-21 | ElectroCore, LLC | Vagal nerve stimulation to avert or treat stroke or transient ischemic attack |
US9126050B2 (en) | 2009-03-20 | 2015-09-08 | ElectroCore, LLC | Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation |
CN101674862A (en) | 2005-11-10 | 2010-03-17 | 电子核心公司 | Electrical stimulation treatment of bronchial constriction |
US11297445B2 (en) | 2005-11-10 | 2022-04-05 | Electrocore, Inc. | Methods and devices for treating primary headache |
US11351363B2 (en) | 2005-11-10 | 2022-06-07 | Electrocore, Inc. | Nerve stimulation devices and methods for treating cardiac arrhythmias |
US8676330B2 (en) | 2009-03-20 | 2014-03-18 | ElectroCore, LLC | Electrical and magnetic stimulators used to treat migraine/sinus headache and comorbid disorders |
US8874227B2 (en) | 2009-03-20 | 2014-10-28 | ElectroCore, LLC | Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient |
US8868177B2 (en) | 2009-03-20 | 2014-10-21 | ElectroCore, LLC | Non-invasive treatment of neurodegenerative diseases |
US9174066B2 (en) | 2009-03-20 | 2015-11-03 | ElectroCore, LLC | Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient |
US10441780B2 (en) | 2005-11-10 | 2019-10-15 | Electrocore, Inc. | Systems and methods for vagal nerve stimulation |
US8812112B2 (en) | 2005-11-10 | 2014-08-19 | ElectroCore, LLC | Electrical treatment of bronchial constriction |
US9037247B2 (en) | 2005-11-10 | 2015-05-19 | ElectroCore, LLC | Non-invasive treatment of bronchial constriction |
US8983628B2 (en) | 2009-03-20 | 2015-03-17 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
US20110125203A1 (en) | 2009-03-20 | 2011-05-26 | ElectroCore, LLC. | Magnetic Stimulation Devices and Methods of Therapy |
US7657310B2 (en) | 2006-01-26 | 2010-02-02 | Cyberonics, Inc. | Treatment of reproductive endocrine disorders by vagus nerve stimulation |
US7801601B2 (en) | 2006-01-27 | 2010-09-21 | Cyberonics, Inc. | Controlling neuromodulation using stimulus modalities |
EP1984064A4 (en) | 2006-02-10 | 2009-11-11 | Electrocore Inc | Methods and apparatus for treating anaphylaxis using electrical modulation |
WO2007094828A2 (en) | 2006-02-10 | 2007-08-23 | Electrocore, Inc. | Electrical stimulation treatment of hypotension |
US8027718B2 (en) * | 2006-03-07 | 2011-09-27 | Mayo Foundation For Medical Education And Research | Regional anesthetic |
EP2026874B1 (en) | 2006-03-29 | 2015-05-20 | Dignity Health | Vagus nerve stimulation system |
US20080183237A1 (en) * | 2006-04-18 | 2008-07-31 | Electrocore, Inc. | Methods And Apparatus For Treating Ileus Condition Using Electrical Signals |
US20100174340A1 (en) * | 2006-04-18 | 2010-07-08 | Electrocore, Inc. | Methods and Apparatus for Applying Energy to Patients |
US7869885B2 (en) | 2006-04-28 | 2011-01-11 | Cyberonics, Inc | Threshold optimization for tissue stimulation therapy |
US9020597B2 (en) | 2008-11-12 | 2015-04-28 | Endostim, Inc. | Device and implantation system for electrical stimulation of biological systems |
US8160709B2 (en) | 2006-05-18 | 2012-04-17 | Endostim, Inc. | Use of electrical stimulation of the lower esophageal sphincter to modulate lower esophageal sphincter pressure |
US8135478B2 (en) * | 2006-07-13 | 2012-03-13 | Rainbow Medical Ltd | Peltier unidirectional and selective nerve stimulation |
US7761168B2 (en) * | 2006-07-13 | 2010-07-20 | Yossi Gross | Peltier unidirectional and selective nerve stimulation |
US20080071173A1 (en) * | 2006-09-18 | 2008-03-20 | Aldrich William N | Visualizing Formation of Ablation Lesions |
US11577077B2 (en) * | 2006-10-09 | 2023-02-14 | Endostim, Inc. | Systems and methods for electrical stimulation of biological systems |
US20150224310A1 (en) * | 2006-10-09 | 2015-08-13 | Endostim, Inc. | Device and Implantation System for Electrical Stimulation of Biological Systems |
US9724510B2 (en) * | 2006-10-09 | 2017-08-08 | Endostim, Inc. | System and methods for electrical stimulation of biological systems |
US9345879B2 (en) | 2006-10-09 | 2016-05-24 | Endostim, Inc. | Device and implantation system for electrical stimulation of biological systems |
US7738961B2 (en) * | 2006-10-09 | 2010-06-15 | Endostim, Inc. | Method and apparatus for treatment of the gastrointestinal tract |
US8543210B2 (en) * | 2008-01-25 | 2013-09-24 | Endostim, Inc. | Device and implantation system for electrical stimulation of biological systems |
US7869867B2 (en) | 2006-10-27 | 2011-01-11 | Cyberonics, Inc. | Implantable neurostimulator with refractory stimulation |
US8874216B2 (en) * | 2006-11-03 | 2014-10-28 | Gep Technology, Inc. | Apparatus and methods for minimally invasive obesity treatment |
US20100217347A1 (en) * | 2006-12-16 | 2010-08-26 | Greatbatch, Inc. | Neurostimulation for the treatment of pulmonary disorders |
US7706875B2 (en) | 2007-01-25 | 2010-04-27 | Cyberonics, Inc. | Modulation of drug effects by vagus nerve stimulation |
WO2008100974A2 (en) * | 2007-02-13 | 2008-08-21 | Sharma Virender K | Method and apparatus for electrical stimulation of the pancreatico-biliary system |
US8068918B2 (en) | 2007-03-09 | 2011-11-29 | Enteromedics Inc. | Remote monitoring and control of implantable devices |
US8224436B2 (en) * | 2007-04-02 | 2012-07-17 | Cardiac Research, Inc. | Unidirectional neural stimulation systems, devices and methods |
US7962214B2 (en) | 2007-04-26 | 2011-06-14 | Cyberonics, Inc. | Non-surgical device and methods for trans-esophageal vagus nerve stimulation |
US7904175B2 (en) | 2007-04-26 | 2011-03-08 | Cyberonics, Inc. | Trans-esophageal vagus nerve stimulation |
US7869884B2 (en) | 2007-04-26 | 2011-01-11 | Cyberonics, Inc. | Non-surgical device and methods for trans-esophageal vagus nerve stimulation |
US7974701B2 (en) | 2007-04-27 | 2011-07-05 | Cyberonics, Inc. | Dosing limitation for an implantable medical device |
WO2009029614A1 (en) | 2007-08-27 | 2009-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
US8696543B2 (en) | 2007-10-11 | 2014-04-15 | Kirk Promotion Ltd. | Method for controlling flow of intestinal contents in a patient's intestines |
BRPI0817871B8 (en) * | 2007-10-11 | 2021-06-22 | Implantica Patent Ltd | device for controlling the flow in an organ of the body |
US20090149799A1 (en) * | 2007-12-05 | 2009-06-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for chemical modulation of neural activity |
US8180446B2 (en) | 2007-12-05 | 2012-05-15 | The Invention Science Fund I, Llc | Method and system for cyclical neural modulation based on activity state |
US8160695B2 (en) | 2007-12-05 | 2012-04-17 | The Invention Science Fund I, Llc | System for chemical modulation of neural activity |
US8170660B2 (en) * | 2007-12-05 | 2012-05-01 | The Invention Science Fund I, Llc | System for thermal modulation of neural activity |
US8165668B2 (en) | 2007-12-05 | 2012-04-24 | The Invention Science Fund I, Llc | Method for magnetic modulation of neural conduction |
US8170658B2 (en) | 2007-12-05 | 2012-05-01 | The Invention Science Fund I, Llc | System for electrical modulation of neural conduction |
US20090149797A1 (en) * | 2007-12-05 | 2009-06-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System for reversible chemical modulation of neural activity |
US8195287B2 (en) | 2007-12-05 | 2012-06-05 | The Invention Science Fund I, Llc | Method for electrical modulation of neural conduction |
US8180447B2 (en) | 2007-12-05 | 2012-05-15 | The Invention Science Fund I, Llc | Method for reversible chemical modulation of neural activity |
US8165669B2 (en) | 2007-12-05 | 2012-04-24 | The Invention Science Fund I, Llc | System for magnetic modulation of neural conduction |
US8571643B2 (en) | 2010-09-16 | 2013-10-29 | Flint Hills Scientific, Llc | Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex |
US8337404B2 (en) | 2010-10-01 | 2012-12-25 | Flint Hills Scientific, Llc | Detecting, quantifying, and/or classifying seizures using multimodal data |
US8382667B2 (en) | 2010-10-01 | 2013-02-26 | Flint Hills Scientific, Llc | Detecting, quantifying, and/or classifying seizures using multimodal data |
US9005106B2 (en) | 2008-01-31 | 2015-04-14 | Enopace Biomedical Ltd | Intra-aortic electrical counterpulsation |
US8538535B2 (en) | 2010-08-05 | 2013-09-17 | Rainbow Medical Ltd. | Enhancing perfusion by contraction |
US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
WO2009114008A1 (en) * | 2008-03-11 | 2009-09-17 | Sharma Virender K | Method and apparatus for treatment of the gastrointestinal tract |
US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
US9211409B2 (en) | 2008-03-31 | 2015-12-15 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of T-cell activity |
US8204603B2 (en) * | 2008-04-25 | 2012-06-19 | Cyberonics, Inc. | Blocking exogenous action potentials by an implantable medical device |
US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
EP2662046B1 (en) | 2008-05-09 | 2023-03-15 | Nuvaira, Inc. | Systems and assemblies for treating a bronchial tree |
US7890182B2 (en) | 2008-05-15 | 2011-02-15 | Boston Scientific Neuromodulation Corporation | Current steering for an implantable stimulator device involving fractionalized stimulation pulses |
EP2318089A4 (en) | 2008-07-11 | 2011-08-10 | Gep Technology Inc | Apparatus and methods for minimally invasive obesity treatment |
US8768469B2 (en) | 2008-08-08 | 2014-07-01 | Enteromedics Inc. | Systems for regulation of blood pressure and heart rate |
US9079028B2 (en) | 2008-10-09 | 2015-07-14 | Virender K. Sharma | Method and apparatus for stimulating the vascular system |
US10603489B2 (en) | 2008-10-09 | 2020-03-31 | Virender K. Sharma | Methods and apparatuses for stimulating blood vessels in order to control, treat, and/or prevent a hemorrhage |
US8457747B2 (en) | 2008-10-20 | 2013-06-04 | Cyberonics, Inc. | Neurostimulation with signal duration determined by a cardiac cycle |
US8417344B2 (en) | 2008-10-24 | 2013-04-09 | Cyberonics, Inc. | Dynamic cranial nerve stimulation based on brain state determination from cardiac data |
US8255057B2 (en) | 2009-01-29 | 2012-08-28 | Nevro Corporation | Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions |
JP5726084B2 (en) * | 2008-11-11 | 2015-05-27 | シファメド・ホールディングス・エルエルシー | Thin electrode assembly |
US9795442B2 (en) | 2008-11-11 | 2017-10-24 | Shifamed Holdings, Llc | Ablation catheters |
WO2010059617A2 (en) | 2008-11-18 | 2010-05-27 | Setpoint Medical Corporation | Devices and methods for optimizing electrode placement for anti-inflamatory stimulation |
US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
US20100191304A1 (en) | 2009-01-23 | 2010-07-29 | Scott Timothy L | Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation |
US9370654B2 (en) * | 2009-01-27 | 2016-06-21 | Medtronic, Inc. | High frequency stimulation to block laryngeal stimulation during vagal nerve stimulation |
US10512769B2 (en) | 2009-03-20 | 2019-12-24 | Electrocore, Inc. | Non-invasive magnetic or electrical nerve stimulation to treat or prevent autism spectrum disorders and other disorders of psychological development |
US10232178B2 (en) | 2009-03-20 | 2019-03-19 | Electrocore, Inc. | Non-invasive magnetic or electrical nerve stimulation to treat or prevent dementia |
US9174045B2 (en) | 2009-03-20 | 2015-11-03 | ElectroCore, LLC | Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence |
US10376696B2 (en) | 2009-03-20 | 2019-08-13 | Electrocore, Inc. | Medical self-treatment using non-invasive vagus nerve stimulation |
US9254383B2 (en) | 2009-03-20 | 2016-02-09 | ElectroCore, LLC | Devices and methods for monitoring non-invasive vagus nerve stimulation |
US9403001B2 (en) | 2009-03-20 | 2016-08-02 | ElectroCore, LLC | Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders |
US11229790B2 (en) | 2013-01-15 | 2022-01-25 | Electrocore, Inc. | Mobile phone for treating a patient with seizures |
US9333347B2 (en) | 2010-08-19 | 2016-05-10 | ElectroCore, LLC | Devices and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation on the neck of a patient |
US10252074B2 (en) | 2009-03-20 | 2019-04-09 | ElectroCore, LLC | Nerve stimulation methods for averting imminent onset or episode of a disease |
US9375571B2 (en) | 2013-01-15 | 2016-06-28 | ElectroCore, LLC | Mobile phone using non-invasive nerve stimulation |
US8918178B2 (en) | 2009-03-20 | 2014-12-23 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
US10286212B2 (en) | 2009-03-20 | 2019-05-14 | Electrocore, Inc. | Nerve stimulation methods for averting imminent onset or episode of a disease |
US10220207B2 (en) | 2009-03-20 | 2019-03-05 | Electrocore, Inc. | Nerve stimulation methods for averting imminent onset or episode of a disease |
US8983629B2 (en) | 2009-03-20 | 2015-03-17 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
US9248286B2 (en) | 2009-03-20 | 2016-02-02 | ElectroCore, LLC | Medical self-treatment using non-invasive vagus nerve stimulation |
CA2757612A1 (en) | 2009-04-03 | 2010-10-07 | Intrapace, Inc. | Feedback systems and methods to enhance obstructive and other obesity treatments |
US8239028B2 (en) | 2009-04-24 | 2012-08-07 | Cyberonics, Inc. | Use of cardiac parameters in methods and systems for treating a chronic medical condition |
US8827912B2 (en) | 2009-04-24 | 2014-09-09 | Cyberonics, Inc. | Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters |
US8788034B2 (en) | 2011-05-09 | 2014-07-22 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
US8414559B2 (en) | 2009-05-07 | 2013-04-09 | Rainbow Medical Ltd. | Gastroretentive duodenal pill |
WO2010144578A2 (en) | 2009-06-09 | 2010-12-16 | Setpoint Medical Corporation | Nerve cuff with pocket for leadless stimulator |
EP2445568B1 (en) * | 2009-06-24 | 2020-09-23 | Kalila Medical, Inc. | Steerable medical delivery devices |
CN102639077B (en) | 2009-10-27 | 2015-05-13 | 赫莱拉公司 | Delivery devices with coolable energy emitting assemblies |
US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
EP4111995A1 (en) | 2009-11-11 | 2023-01-04 | Nuvaira, Inc. | Device for treating tissue and controlling stenosis |
US11051744B2 (en) | 2009-11-17 | 2021-07-06 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
CN105126248B (en) | 2009-12-23 | 2018-06-12 | 赛博恩特医疗器械公司 | For treating the nerve stimulation apparatus of chronic inflammation and system |
US11717681B2 (en) | 2010-03-05 | 2023-08-08 | Endostim, Inc. | Systems and methods for treating gastroesophageal reflux disease |
US8447403B2 (en) | 2010-03-05 | 2013-05-21 | Endostim, Inc. | Device and implantation system for electrical stimulation of biological systems |
CA2793737A1 (en) | 2010-03-24 | 2011-09-29 | Shifamed Holdings, Llc | Intravascular tissue disruption |
US8649871B2 (en) | 2010-04-29 | 2014-02-11 | Cyberonics, Inc. | Validity test adaptive constraint modification for cardiac data used for detection of state changes |
US8562536B2 (en) | 2010-04-29 | 2013-10-22 | Flint Hills Scientific, Llc | Algorithm for detecting a seizure from cardiac data |
US8831732B2 (en) | 2010-04-29 | 2014-09-09 | Cyberonics, Inc. | Method, apparatus and system for validating and quantifying cardiac beat data quality |
US9655677B2 (en) | 2010-05-12 | 2017-05-23 | Shifamed Holdings, Llc | Ablation catheters including a balloon and electrodes |
WO2011143468A2 (en) | 2010-05-12 | 2011-11-17 | Shifamed, Llc | Low profile electrode assembly |
US8679009B2 (en) | 2010-06-15 | 2014-03-25 | Flint Hills Scientific, Llc | Systems approach to comorbidity assessment |
US8641646B2 (en) | 2010-07-30 | 2014-02-04 | Cyberonics, Inc. | Seizure detection using coordinate data |
US11400288B2 (en) | 2010-08-19 | 2022-08-02 | Electrocore, Inc | Devices and methods for electrical stimulation and their use for vagus nerve stimulation on the neck of a patient |
US9358381B2 (en) | 2011-03-10 | 2016-06-07 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
US20200086108A1 (en) | 2010-08-19 | 2020-03-19 | Electrocore, Inc. | Vagal nerve stimulation to reduce inflammation associated with an aneurysm |
US11191953B2 (en) | 2010-08-19 | 2021-12-07 | Electrocore, Inc. | Systems and methods for vagal nerve stimulation |
US8805519B2 (en) | 2010-09-30 | 2014-08-12 | Nevro Corporation | Systems and methods for detecting intrathecal penetration |
WO2012045030A2 (en) | 2010-10-01 | 2012-04-05 | Intrapace, Inc. | Feedback systems and methods to enhance obstructive and other obesity treatments, optionally using multiple sensors |
US8684921B2 (en) | 2010-10-01 | 2014-04-01 | Flint Hills Scientific Llc | Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis |
US11432760B2 (en) | 2011-01-12 | 2022-09-06 | Electrocore, Inc. | Devices and methods for remote therapy and patient monitoring |
US9504390B2 (en) | 2011-03-04 | 2016-11-29 | Globalfoundries Inc. | Detecting, assessing and managing a risk of death in epilepsy |
US9399134B2 (en) | 2011-03-10 | 2016-07-26 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
US10173048B2 (en) | 2011-03-10 | 2019-01-08 | Electrocore, Inc. | Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders |
US11511109B2 (en) | 2011-03-10 | 2022-11-29 | Electrocore, Inc. | Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders |
US11458297B2 (en) | 2011-03-10 | 2022-10-04 | Electrocore, Inc | Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders |
WO2012142539A1 (en) | 2011-04-14 | 2012-10-18 | Endostim, Inc. | Systems and methods for treating gastroesophageal reflux disease |
US8725239B2 (en) | 2011-04-25 | 2014-05-13 | Cyberonics, Inc. | Identifying seizures using heart rate decrease |
US9402550B2 (en) | 2011-04-29 | 2016-08-02 | Cybertronics, Inc. | Dynamic heart rate threshold for neurological event detection |
WO2012151396A2 (en) | 2011-05-03 | 2012-11-08 | Shifamed Holdings, Llc | Steerable delivery sheaths |
US9566426B2 (en) | 2011-08-31 | 2017-02-14 | ElectroCore, LLC | Systems and methods for vagal nerve stimulation |
US9925367B2 (en) | 2011-09-02 | 2018-03-27 | Endostim, Inc. | Laparoscopic lead implantation method |
WO2013033673A1 (en) | 2011-09-02 | 2013-03-07 | Endostim, Inc. | Endoscopic lead implantation method |
US9526637B2 (en) | 2011-09-09 | 2016-12-27 | Enopace Biomedical Ltd. | Wireless endovascular stent-based electrodes |
US9549677B2 (en) | 2011-10-14 | 2017-01-24 | Flint Hills Scientific, L.L.C. | Seizure detection methods, apparatus, and systems using a wavelet transform maximum modulus algorithm |
US10576278B2 (en) | 2012-02-21 | 2020-03-03 | Virender K. Sharma | System and method for electrical stimulation of anorectal structures to treat urinary dysfunction |
US9782583B2 (en) | 2012-02-21 | 2017-10-10 | Virender K. Sharma | System and method for electrical stimulation of anorectal structures to treat urinary dysfunction |
US8706234B2 (en) | 2012-02-21 | 2014-04-22 | Virender K. Sharma | System and method for electrical stimulation of anorectal structures to treat anal dysfunction |
EP2822646B1 (en) | 2012-03-09 | 2023-10-18 | Mayo Foundation For Medical Education And Research | Modulating afferent signals to treat medical conditions |
US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
US8961550B2 (en) | 2012-04-17 | 2015-02-24 | Indian Wells Medical, Inc. | Steerable endoluminal punch |
US10448839B2 (en) | 2012-04-23 | 2019-10-22 | Livanova Usa, Inc. | Methods, systems and apparatuses for detecting increased risk of sudden death |
US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
AU2013305543A1 (en) | 2012-08-23 | 2015-03-19 | Endostim, Inc. | Device and implantation system for electrical stimulation of biological systems |
EP2934540B1 (en) | 2012-12-24 | 2023-08-02 | Neurogastrx, Inc. | Methods for treating gi tract disorders |
US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
US10293160B2 (en) | 2013-01-15 | 2019-05-21 | Electrocore, Inc. | Mobile phone for treating a patient with dementia |
US10220211B2 (en) | 2013-01-22 | 2019-03-05 | Livanova Usa, Inc. | Methods and systems to diagnose depression |
US9174049B2 (en) | 2013-01-27 | 2015-11-03 | ElectroCore, LLC | Systems and methods for electrical stimulation of sphenopalatine ganglion and other branches of cranial nerves |
US9498619B2 (en) | 2013-02-26 | 2016-11-22 | Endostim, Inc. | Implantable electrical stimulation leads |
US9011365B2 (en) | 2013-03-12 | 2015-04-21 | Medibotics Llc | Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food |
US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
US9370660B2 (en) | 2013-03-29 | 2016-06-21 | Rainbow Medical Ltd. | Independently-controlled bidirectional nerve stimulation |
US10349824B2 (en) | 2013-04-08 | 2019-07-16 | Apama Medical, Inc. | Tissue mapping and visualization systems |
CN110141177B (en) | 2013-04-08 | 2021-11-23 | 阿帕玛医疗公司 | Ablation catheter |
US10098694B2 (en) | 2013-04-08 | 2018-10-16 | Apama Medical, Inc. | Tissue ablation and monitoring thereof |
US9427581B2 (en) | 2013-04-28 | 2016-08-30 | ElectroCore, LLC | Devices and methods for treating medical disorders with evoked potentials and vagus nerve stimulation |
WO2015009495A1 (en) | 2013-07-17 | 2015-01-22 | Cook Medical Technologies Llc | Ablation mesh |
CN105848708A (en) | 2013-09-03 | 2016-08-10 | 恩多斯蒂姆股份有限公司 | Methods and systems of electrode polarity switching in electrical stimulation therapy |
US9205258B2 (en) | 2013-11-04 | 2015-12-08 | ElectroCore, LLC | Nerve stimulator system |
EP3065673A4 (en) | 2013-11-06 | 2017-07-12 | Enopace Biomedical Ltd. | Wireless endovascular stent-based electrodes |
US10123896B2 (en) | 2014-03-06 | 2018-11-13 | Mayo Foundation For Medical Education And Research | Apparatus and methods of inducing weight loss using blood flow control |
EP3145582B1 (en) | 2014-05-20 | 2020-10-21 | Nevro Corporation | Implanted pulse generators with reduced power consumption via signal strength/duration characteristics, and associated systems |
WO2015200369A1 (en) | 2014-06-24 | 2015-12-30 | Neurogastrx, Inc. | Prodrugs of metopimazine |
US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
WO2016081468A2 (en) | 2014-11-17 | 2016-05-26 | Endostim, Inc. | Implantable electro-medical device programmable for improved operational life |
WO2016126807A1 (en) | 2015-02-03 | 2016-08-11 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
US10376145B2 (en) | 2015-02-24 | 2019-08-13 | Elira, Inc. | Systems and methods for enabling a patient to achieve a weight loss objective using an electrical dermal patch |
WO2016138176A1 (en) | 2015-02-24 | 2016-09-01 | Elira Therapeutics Llc | Systems and methods for enabling appetite modulation and/or improving dietary compliance using an electro-dermal patch |
US10335302B2 (en) | 2015-02-24 | 2019-07-02 | Elira, Inc. | Systems and methods for using transcutaneous electrical stimulation to enable dietary interventions |
US10765863B2 (en) | 2015-02-24 | 2020-09-08 | Elira, Inc. | Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy |
US10864367B2 (en) | 2015-02-24 | 2020-12-15 | Elira, Inc. | Methods for using an electrical dermal patch in a manner that reduces adverse patient reactions |
US9956393B2 (en) | 2015-02-24 | 2018-05-01 | Elira, Inc. | Systems for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch |
WO2016160694A1 (en) | 2015-03-27 | 2016-10-06 | Shifamed Holdings, Llc | Steerable medical devices, systems, and methods of use |
EP3285849A4 (en) | 2015-04-24 | 2018-12-26 | Shifamed Holdings, LLC | Steerable medical devices, systems, and methods of use |
US11318310B1 (en) | 2015-10-26 | 2022-05-03 | Nevro Corp. | Neuromodulation for altering autonomic functions, and associated systems and methods |
US10105540B2 (en) | 2015-11-09 | 2018-10-23 | Bluewind Medical Ltd. | Optimization of application of current |
WO2017083257A1 (en) | 2015-11-09 | 2017-05-18 | Shifamed Holdings, Llc | Steering assemblies for medical devices, and methods of use |
WO2017087549A1 (en) | 2015-11-16 | 2017-05-26 | Apama Medical, Inc. | Energy delivery devices |
US10300277B1 (en) | 2015-12-14 | 2019-05-28 | Nevro Corp. | Variable amplitude signals for neurological therapy, and associated systems and methods |
US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
US10314501B2 (en) | 2016-01-20 | 2019-06-11 | Setpoint Medical Corporation | Implantable microstimulators and inductive charging systems |
WO2017127756A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Control of vagal stimulation |
US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
WO2018094207A1 (en) | 2016-11-17 | 2018-05-24 | Endostim, Inc. | Modular stimulation system for the treatment of gastrointestinal disorders |
US10980999B2 (en) | 2017-03-09 | 2021-04-20 | Nevro Corp. | Paddle leads and delivery tools, and associated systems and methods |
US11173307B2 (en) | 2017-08-14 | 2021-11-16 | Setpoint Medical Corporation | Vagus nerve stimulation pre-screening test |
KR102495358B1 (en) | 2017-09-25 | 2023-02-02 | 삼성전자주식회사 | Neuromimetic stimulating apparatus and method thereof |
EP3737459A4 (en) | 2018-01-30 | 2021-10-20 | Nevro Corp. | Efficient use of an implantable pulse generator battery, and associated systems and methods |
EP3758793A4 (en) | 2018-03-29 | 2021-12-08 | Nevro Corp. | Leads having sidewall openings, and associated systems and methods |
CA3096702A1 (en) * | 2018-04-12 | 2019-10-17 | Reshape Lifesciences, Inc. | Simultaneous multi-site vagus nerve neuromodulation for improved glycemic control system and methods |
US11413465B2 (en) | 2018-04-13 | 2022-08-16 | The Penn State Research Foundation | Free-floating millimeter-sized distributed implantable gastric seeds |
US11058875B1 (en) | 2018-09-19 | 2021-07-13 | Nevro Corp. | Motor function in spinal cord injury patients via electrical stimulation, and associated systems and methods |
US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
US11590352B2 (en) | 2019-01-29 | 2023-02-28 | Nevro Corp. | Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods |
US10836757B1 (en) | 2020-04-02 | 2020-11-17 | Neurogastrx, Inc. | Polymorphic forms of metopimazine |
US11400299B1 (en) | 2021-09-14 | 2022-08-02 | Rainbow Medical Ltd. | Flexible antenna for stimulator |
Citations (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3128760A (en) * | 1961-08-21 | 1964-04-14 | Winston Electronics Ltd | Vagotomy test apparatus |
US4114625A (en) * | 1976-12-02 | 1978-09-19 | Onat Mustafa V | Anti-vomiting, anti-aspirating oral-nasal gastric tube |
US4198963A (en) * | 1978-10-19 | 1980-04-22 | Michigan Instruments, Inc. | Cardiopulmonary resuscitator, defibrillator and monitor |
US4867164A (en) * | 1983-09-14 | 1989-09-19 | Jacob Zabara | Neurocybernetic prosthesis |
US5025807A (en) * | 1983-09-14 | 1991-06-25 | Jacob Zabara | Neurocybernetic prosthesis |
US5188104A (en) * | 1991-02-01 | 1993-02-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
US5199430A (en) * | 1991-03-11 | 1993-04-06 | Case Western Reserve University | Micturitional assist device |
US5215086A (en) * | 1991-05-03 | 1993-06-01 | Cyberonics, Inc. | Therapeutic treatment of migraine symptoms by stimulation |
US5226429A (en) * | 1991-06-20 | 1993-07-13 | Inamed Development Co. | Laparoscopic gastric band and method |
US5226426A (en) * | 1990-12-18 | 1993-07-13 | Inbae Yoon | Safety penetrating instrument |
US5231988A (en) * | 1991-08-09 | 1993-08-03 | Cyberonics, Inc. | Treatment of endocrine disorders by nerve stimulation |
US5236480A (en) * | 1989-01-05 | 1993-08-17 | Camfil Ab | Air filter for workstations and methods of making and using such air filter |
US5292344A (en) * | 1992-07-10 | 1994-03-08 | Douglas Donald D | Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system, with optional delivery port |
US5299569A (en) * | 1991-05-03 | 1994-04-05 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by nerve stimulation |
US5330515A (en) * | 1992-06-17 | 1994-07-19 | Cyberonics, Inc. | Treatment of pain by vagal afferent stimulation |
US5335657A (en) * | 1991-05-03 | 1994-08-09 | Cyberonics, Inc. | Therapeutic treatment of sleep disorder by nerve stimulation |
US5344438A (en) * | 1993-04-16 | 1994-09-06 | Medtronic, Inc. | Cuff electrode |
US5423872A (en) * | 1992-05-29 | 1995-06-13 | Cigaina; Valerio | Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient |
US5437291A (en) * | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
US5514175A (en) * | 1994-11-09 | 1996-05-07 | Cerebral Stimulation, Inc. | Auricular electrical stimulator |
US5540730A (en) * | 1995-06-06 | 1996-07-30 | Cyberonics, Inc. | Treatment of motility disorders by nerve stimulation |
US5601604A (en) * | 1993-05-27 | 1997-02-11 | Inamed Development Co. | Universal gastric band |
US5620955A (en) * | 1993-06-18 | 1997-04-15 | Peptide Technologies Corporation | Bombesin receptor antagonists and uses thereof |
US5716385A (en) * | 1996-11-12 | 1998-02-10 | University Of Virginia | Crural diaphragm pacemaker and method for treating esophageal reflux disease |
US5747060A (en) * | 1996-03-26 | 1998-05-05 | Euro-Celtique, S.A. | Prolonged local anesthesia with colchicine |
US5861014A (en) * | 1997-04-30 | 1999-01-19 | Medtronic, Inc. | Method and apparatus for sensing a stimulating gastrointestinal tract on-demand |
US5919216A (en) * | 1997-06-16 | 1999-07-06 | Medtronic, Inc. | System and method for enhancement of glucose production by stimulation of pancreatic beta cells |
US6091992A (en) * | 1997-12-15 | 2000-07-18 | Medtronic, Inc. | Method and apparatus for electrical stimulation of the gastrointestinal tract |
US6093167A (en) * | 1997-06-16 | 2000-07-25 | Medtronic, Inc. | System for pancreatic stimulation and glucose measurement |
US6097984A (en) * | 1998-11-25 | 2000-08-01 | Medtronic, Inc. | System and method of stimulation for treating gastro-esophageal reflux disease |
US6098629A (en) * | 1999-04-07 | 2000-08-08 | Endonetics, Inc. | Submucosal esophageal bulking device |
US6104955A (en) * | 1997-12-15 | 2000-08-15 | Medtronic, Inc. | Method and apparatus for electrical stimulation of the gastrointestinal tract |
US6111715A (en) * | 1997-01-13 | 2000-08-29 | Hitachi, Ltd. | Storage apparatus using a magnetoresistive head that employs a sense current selected from plural predetermined sense currents |
US6216039B1 (en) * | 1997-05-02 | 2001-04-10 | Medtronic Inc. | Method and apparatus for treating irregular gastric rhythms |
US6238423B1 (en) * | 1997-01-13 | 2001-05-29 | Medtronic, Inc. | Apparatus and method for treating chronic constipation |
US6243607B1 (en) * | 1996-09-05 | 2001-06-05 | University Technologies International Inc. | Gastro-intestinal electrical pacemaker |
US6261280B1 (en) * | 1999-03-22 | 2001-07-17 | Medtronic, Inc | Method of obtaining a measure of blood glucose |
US6292703B1 (en) * | 1998-10-08 | 2001-09-18 | Biotronik Mess-Und Therapiegerate Gmbh & Co. | Neural electrode arrangement |
US6290961B1 (en) * | 1993-12-28 | 2001-09-18 | Allergan, Inc. | Method for treating dystonia with botulinum toxin type B |
US6341236B1 (en) * | 1999-04-30 | 2002-01-22 | Ivan Osorio | Vagal nerve stimulation techniques for treatment of epileptic seizures |
US20020012828A1 (en) * | 1998-09-07 | 2002-01-31 | Bojidara Grigorova | Fuel cell and gold-containing catalyst for use therein |
US20020032468A1 (en) * | 1996-04-30 | 2002-03-14 | Hill Michael R.S. | Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure |
US6364899B1 (en) * | 1998-01-23 | 2002-04-02 | Innercool Therapies, Inc. | Heat pipe nerve cooler |
US6369079B1 (en) * | 1998-06-15 | 2002-04-09 | Sepracor, Inc. | Methods for treating irritable bowel syndrome using optically pure (+) norcisapride |
US20020052336A1 (en) * | 1999-02-26 | 2002-05-02 | Yerxa Benjamin R. | Method of treating gastrointestinal tract disease with purinergic receptor agonists |
US20020055779A1 (en) * | 1996-03-05 | 2002-05-09 | Brian J. Andrews | Neural prosthesis |
US20020072780A1 (en) * | 2000-09-26 | 2002-06-13 | Transneuronix, Inc. | Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity |
US6405732B1 (en) * | 1994-06-24 | 2002-06-18 | Curon Medical, Inc. | Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors |
US20020087192A1 (en) * | 2001-01-02 | 2002-07-04 | Barrett Burke T. | Treatment of obesity by sub-diaphragmatic nerve stimulation |
US20020094962A1 (en) * | 2000-12-01 | 2002-07-18 | Gary Ashley | Motilide compounds |
US20020103424A1 (en) * | 2001-01-31 | 2002-08-01 | Swoyer John M. | Implantable medical device affixed internally within the gastrointestinal tract |
US20030014086A1 (en) * | 2001-07-14 | 2003-01-16 | Sharma Virender K. | Method and apparatus for electrical stimulation of the lower esophageal sphincter |
US20030018367A1 (en) * | 2001-07-23 | 2003-01-23 | Dilorenzo Daniel John | Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease |
US20030040785A1 (en) * | 2001-08-21 | 2003-02-27 | Maschino Steve E. | Circumneural electrode assembly |
US20030045909A1 (en) * | 2001-08-31 | 2003-03-06 | Biocontrol Medical Ltd. | Selective nerve fiber stimulation for treating heart conditions |
US20030045914A1 (en) * | 2001-08-31 | 2003-03-06 | Biocontrol Medical Ltd. | Treatment of disorders by unidirectional nerve stimulation |
US6532388B1 (en) * | 1996-04-30 | 2003-03-11 | Medtronic, Inc. | Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure |
US20030074039A1 (en) * | 1999-06-25 | 2003-04-17 | Puskas John D. | Devices and methods for vagus nerve stimulation |
US6558708B1 (en) * | 1995-05-17 | 2003-05-06 | Cedars-Sinai Medical Center | Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia |
US6571127B1 (en) * | 1997-07-16 | 2003-05-27 | Impulse Dynamics N.V. | Method of increasing the motility of a GI tract |
US6587719B1 (en) * | 1999-07-01 | 2003-07-01 | Cyberonics, Inc. | Treatment of obesity by bilateral vagus nerve stimulation |
US6591137B1 (en) * | 2000-11-09 | 2003-07-08 | Neuropace, Inc. | Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders |
US20030144709A1 (en) * | 2002-01-25 | 2003-07-31 | Cyberonics, Inc. | Nerve stimulation as a treatment for pain |
US6610713B2 (en) * | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
US6611715B1 (en) * | 1998-10-26 | 2003-08-26 | Birinder R. Boveja | Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator |
US20040039425A1 (en) * | 2002-05-29 | 2004-02-26 | Beverley Greenwood-Van Meerveld | Spinal cord stimulation as treatment for functional bowel disorders |
US20040059383A1 (en) * | 1997-08-26 | 2004-03-25 | Puskas John D. | Methods of indirectly stimulating the vagus nerve with an electrical field |
US20040086531A1 (en) * | 2002-11-05 | 2004-05-06 | Allergan, Inc. | Methods for treating ulcers and gastroesophageal reflux disease |
US20040089313A1 (en) * | 1998-02-19 | 2004-05-13 | Curon Medical, Inc. | Systems and methods for treating obesity and other gastrointestinal conditions |
US6746474B2 (en) * | 2002-05-31 | 2004-06-08 | Vahid Saadat | Apparatus and methods for cooling a region within the body |
US20040127953A1 (en) * | 2001-02-20 | 2004-07-01 | Kilgore Kevin L. | Systems and methods for reversibly blocking nerve activity |
US20040167583A1 (en) * | 2003-02-03 | 2004-08-26 | Enteromedics, Inc. | Electrode band apparatus and method |
US6853862B1 (en) * | 1999-12-03 | 2005-02-08 | Medtronic, Inc. | Gastroelectric stimulation for influencing pancreatic secretions |
US20050038484A1 (en) * | 2003-02-03 | 2005-02-17 | Enteromedics, Inc. | Controlled vagal blockage therapy |
US20050049655A1 (en) * | 2003-08-27 | 2005-03-03 | Boveja Birinder R. | System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities |
US20050070970A1 (en) * | 2003-09-29 | 2005-03-31 | Knudson Mark B. | Movement disorder stimulation with neural block |
US20050070974A1 (en) * | 2003-09-29 | 2005-03-31 | Knudson Mark B. | Obesity and eating disorder stimulation treatment with neural block |
US20050075693A1 (en) * | 2003-10-02 | 2005-04-07 | Medtronic, Inc. | Driver circuitry switchable between energy transfer and telemetry for an implantable medical device |
US6895278B1 (en) * | 1999-04-14 | 2005-05-17 | Transneuronix, Inc. | Gastric stimulator apparatus and method for use |
US20050131485A1 (en) * | 2003-02-03 | 2005-06-16 | Enteromedics, Inc. | High frequency vagal blockage therapy |
US20050137644A1 (en) * | 1998-10-26 | 2005-06-23 | Boveja Birinder R. | Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders |
US20050143787A1 (en) * | 2002-05-09 | 2005-06-30 | Boveja Birinder R. | Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator |
US20050143378A1 (en) * | 2003-12-29 | 2005-06-30 | Yun Anthony J. | Treatment of conditions through pharmacological modulation of the autonomic nervous system |
US20050149141A1 (en) * | 2004-01-07 | 2005-07-07 | Starkebaum Warren L. | Gastric stimulation for altered perception to treat obesity |
US20050149148A1 (en) * | 2001-05-17 | 2005-07-07 | Medtronic, Inc. | Apparatus and method for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated |
US20060015151A1 (en) * | 2003-03-14 | 2006-01-19 | Aldrich William N | Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures |
US6993391B2 (en) * | 2000-12-11 | 2006-01-31 | Metacure N.V. | Acute and chronic electrical signal therapy for obesity |
US20060036293A1 (en) * | 2004-08-16 | 2006-02-16 | Whitehurst Todd K | Methods for treating gastrointestinal disorders |
US7054690B2 (en) * | 2003-10-22 | 2006-05-30 | Intrapace, Inc. | Gastrointestinal stimulation device |
US20070043400A1 (en) * | 2005-08-17 | 2007-02-22 | Donders Adrianus P | Neural electrode treatment |
Family Cites Families (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3411507A (en) | 1964-04-01 | 1968-11-19 | Medtronic Inc | Method of gastrointestinal stimulation with electrical pulses |
US4441210A (en) | 1981-09-18 | 1984-04-03 | Hochmair Erwin S | Transcutaneous signal transmission system and methods |
US5370675A (en) | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
CA1215128A (en) | 1982-12-08 | 1986-12-09 | Pedro Molina-Negro | Electric nerve stimulator device |
US4702254A (en) * | 1983-09-14 | 1987-10-27 | Jacob Zabara | Neurocybernetic prosthesis |
AT385894B (en) * | 1985-10-04 | 1988-05-25 | Basem Dr Nashef | TUBULAR PROBE |
US5263480A (en) * | 1991-02-01 | 1993-11-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
US5269303A (en) * | 1991-02-22 | 1993-12-14 | Cyberonics, Inc. | Treatment of dementia by nerve stimulation |
US5571150A (en) * | 1994-12-19 | 1996-11-05 | Cyberonics, Inc. | Treatment of patients in coma by nerve stimulation |
US5591217A (en) * | 1995-01-04 | 1997-01-07 | Plexus, Inc. | Implantable stimulator with replenishable, high value capacitive power source and method therefor |
US5707400A (en) * | 1995-09-19 | 1998-01-13 | Cyberonics, Inc. | Treating refractory hypertension by nerve stimulation |
US5690691A (en) * | 1996-05-08 | 1997-11-25 | The Center For Innovative Technology | Gastro-intestinal pacemaker having phased multi-point stimulation |
US5749907A (en) | 1997-02-18 | 1998-05-12 | Pacesetter, Inc. | System and method for identifying and displaying medical data which violate programmable alarm conditions |
US5830434A (en) | 1997-02-26 | 1998-11-03 | Medical University Of South Carolina Foundation For Research Development | Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide |
JP2001513679A (en) | 1997-02-26 | 2001-09-04 | アルフレッド イー マン ファウンデーション フォア サイエンティフィック リサーチ | Battery powered patient subcutaneous insertion device |
US5938596A (en) | 1997-03-17 | 1999-08-17 | Medtronic, Inc. | Medical electrical lead |
US5836994A (en) * | 1997-04-30 | 1998-11-17 | Medtronic, Inc. | Method and apparatus for electrical stimulation of the gastrointestinal tract |
IT1293974B1 (en) | 1997-08-13 | 1999-03-15 | Sorin Biomedica Cardio Spa | ACTIVE IMPLANTABLE DEVICE. |
US5967977A (en) * | 1997-10-03 | 1999-10-19 | Medtronic, Inc. | Transesophageal medical lead |
US6148222A (en) | 1998-07-10 | 2000-11-14 | Cardiocommand, Inc. | Esophageal catheters and method of use |
US6564102B1 (en) | 1998-10-26 | 2003-05-13 | Birinder R. Boveja | Apparatus and method for adjunct (add-on) treatment of coma and traumatic brain injury with neuromodulation using an external stimulator |
US6366814B1 (en) | 1998-10-26 | 2002-04-02 | Birinder R. Boveja | External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders |
US6208902B1 (en) | 1998-10-26 | 2001-03-27 | Birinder Bob Boveja | Apparatus and method for adjunct (add-on) therapy for pain syndromes utilizing an implantable lead and an external stimulator |
US20030212440A1 (en) | 2002-05-09 | 2003-11-13 | Boveja Birinder R. | Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system |
US6505074B2 (en) | 1998-10-26 | 2003-01-07 | Birinder R. Boveja | Method and apparatus for electrical stimulation adjunct (add-on) treatment of urinary incontinence and urological disorders using an external stimulator |
US6615081B1 (en) | 1998-10-26 | 2003-09-02 | Birinder R. Boveja | Apparatus and method for adjunct (add-on) treatment of diabetes by neuromodulation with an external stimulator |
US6678560B1 (en) | 1999-01-21 | 2004-01-13 | Cardiac Pacemakers, Inc. | Cardiac rhythm management system with electrosurgery mode |
US7149773B2 (en) | 1999-07-07 | 2006-12-12 | Medtronic, Inc. | System and method of automated invoicing for communications between an implantable medical device and a remote computer system or health care provider |
US6308105B1 (en) | 1999-07-15 | 2001-10-23 | Medtronic Inc. | Medical electrical stimulation system using an electrode assembly having opposing semi-circular arms |
US6381496B1 (en) | 1999-10-01 | 2002-04-30 | Advanced Bionics Corporation | Parameter context switching for an implanted device |
US6113915A (en) * | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
US6473644B1 (en) * | 1999-10-13 | 2002-10-29 | Cyberonics, Inc. | Method to enhance cardiac capillary growth in heart failure patients |
IT1315260B1 (en) * | 1999-12-07 | 2003-02-03 | Valerio Cigaina | REMOVABLE GASTRIC BANDAGE |
US6418346B1 (en) | 1999-12-14 | 2002-07-09 | Medtronic, Inc. | Apparatus and method for remote therapy and diagnosis in medical devices via interface systems |
SE9904626D0 (en) | 1999-12-16 | 1999-12-16 | Pacesetter Ab | Programming system for medical devices |
US6261572B1 (en) * | 2000-01-11 | 2001-07-17 | Allergan Sales, Inc. | Method for treating a pancreatic disorder with a neurotoxin |
US6612983B1 (en) * | 2000-03-28 | 2003-09-02 | Medtronic, Inc. | Pancreatic secretion response to stimulation test protocol |
US6826428B1 (en) * | 2000-04-11 | 2004-11-30 | The Board Of Regents Of The University Of Texas System | Gastrointestinal electrical stimulation |
US6306423B1 (en) * | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
JP2001356159A (en) * | 2000-06-15 | 2001-12-26 | Seiko Epson Corp | Gps receiving system |
US6505077B1 (en) | 2000-06-19 | 2003-01-07 | Medtronic, Inc. | Implantable medical device with external recharging coil electrical connection |
US7623926B2 (en) | 2000-09-27 | 2009-11-24 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
US6832114B1 (en) | 2000-11-21 | 2004-12-14 | Advanced Bionics Corporation | Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes |
US6761715B2 (en) * | 2001-04-26 | 2004-07-13 | Ronald J. Carroll | Method and device for neurocryo analgesia and anesthesia |
AU2002305357A1 (en) | 2001-05-01 | 2002-11-11 | Second Sight, Llc | High-density array of micro-machined electrodes for neural stimulation |
US7702394B2 (en) | 2001-05-01 | 2010-04-20 | Intrapace, Inc. | Responsive gastric stimulator |
US20060116736A1 (en) | 2001-07-23 | 2006-06-01 | Dilorenzo Daniel J | Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity |
US6622038B2 (en) * | 2001-07-28 | 2003-09-16 | Cyberonics, Inc. | Treatment of movement disorders by near-diaphragmatic nerve stimulation |
US20040036377A1 (en) | 2001-08-15 | 2004-02-26 | Steven Mezinis | High voltage lc electric and magnetic field motivator |
US6760626B1 (en) | 2001-08-29 | 2004-07-06 | Birinder R. Boveja | Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system |
US7974693B2 (en) * | 2001-08-31 | 2011-07-05 | Bio Control Medical (B.C.M.) Ltd. | Techniques for applying, configuring, and coordinating nerve fiber stimulation |
US7734355B2 (en) * | 2001-08-31 | 2010-06-08 | Bio Control Medical (B.C.M.) Ltd. | Treatment of disorders by unidirectional nerve stimulation |
US7187978B2 (en) | 2001-11-01 | 2007-03-06 | Medtronic, Inc. | Method and apparatus for programming an implantable medical device |
US7050856B2 (en) | 2002-01-11 | 2006-05-23 | Medtronic, Inc. | Variation of neural-stimulation parameters |
US6985773B2 (en) * | 2002-02-07 | 2006-01-10 | Cardiac Pacemakers, Inc. | Methods and apparatuses for implantable medical device telemetry power management |
US7689277B2 (en) | 2002-03-22 | 2010-03-30 | Leptos Biomedical, Inc. | Neural stimulation for treatment of metabolic syndrome and type 2 diabetes |
US7689276B2 (en) | 2002-09-13 | 2010-03-30 | Leptos Biomedical, Inc. | Dynamic nerve stimulation for treatment of disorders |
US7236822B2 (en) * | 2002-03-22 | 2007-06-26 | Leptos Biomedical, Inc. | Wireless electric modulation of sympathetic nervous system |
US7239912B2 (en) * | 2002-03-22 | 2007-07-03 | Leptos Biomedical, Inc. | Electric modulation of sympathetic nervous system |
US8145316B2 (en) * | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US7191012B2 (en) | 2003-05-11 | 2007-03-13 | Boveja Birinder R | Method and system for providing pulsed electrical stimulation to a craniel nerve of a patient to provide therapy for neurological and neuropsychiatric disorders |
US20040193229A1 (en) | 2002-05-17 | 2004-09-30 | Medtronic, Inc. | Gastric electrical stimulation for treatment of gastro-esophageal reflux disease |
US7292890B2 (en) * | 2002-06-20 | 2007-11-06 | Advanced Bionics Corporation | Vagus nerve stimulation via unidirectional propagation of action potentials |
WO2004036377A2 (en) | 2002-10-15 | 2004-04-29 | Medtronic Inc. | Configuring and testing treatment therapy parameters for a medical device system |
US6736722B1 (en) | 2002-12-04 | 2004-05-18 | Deere & Company | Unloader tube cleaning system for harvesting apparatus |
WO2004064918A1 (en) | 2003-01-14 | 2004-08-05 | Department Of Veterans Affairs, Office Of General Counsel | Cervical wagal stimulation induced weight loss |
US20040172084A1 (en) * | 2003-02-03 | 2004-09-02 | Knudson Mark B. | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
US7430449B2 (en) | 2003-03-14 | 2008-09-30 | Endovx, Inc. | Methods and apparatus for testing disruption of a vagal nerve |
US7684865B2 (en) * | 2003-03-14 | 2010-03-23 | Endovx, Inc. | Methods and apparatus for treatment of obesity |
US7783358B2 (en) * | 2003-03-14 | 2010-08-24 | Endovx, Inc. | Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes |
DE10318071A1 (en) | 2003-04-17 | 2004-11-25 | Forschungszentrum Jülich GmbH | Device for desynchronizing neuronal brain activity |
US7444184B2 (en) * | 2003-05-11 | 2008-10-28 | Neuro And Cardial Technologies, Llc | Method and system for providing therapy for bulimia/eating disorders by providing electrical pulses to vagus nerve(s) |
US7620454B2 (en) * | 2003-05-19 | 2009-11-17 | Medtronic, Inc. | Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof |
US7742818B2 (en) * | 2003-05-19 | 2010-06-22 | Medtronic, Inc. | Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof |
US7149574B2 (en) | 2003-06-09 | 2006-12-12 | Palo Alto Investors | Treatment of conditions through electrical modulation of the autonomic nervous system |
US7797058B2 (en) | 2004-08-04 | 2010-09-14 | Ndi Medical, Llc | Devices, systems, and methods employing a molded nerve cuff electrode |
US7991479B2 (en) * | 2003-10-02 | 2011-08-02 | Medtronic, Inc. | Neurostimulator programmer with clothing attachable antenna |
US7715913B1 (en) * | 2004-02-10 | 2010-05-11 | Koninklijke Philips Electronics, N.V. | External defibrillator with training mode and method of use |
US7486993B2 (en) * | 2004-08-05 | 2009-02-03 | Neurotone Systems, Inc. | Brain stimulation method and device |
US8214047B2 (en) | 2004-09-27 | 2012-07-03 | Advanced Neuromodulation Systems, Inc. | Method of using spinal cord stimulation to treat gastrointestinal and/or eating disorders or conditions |
US7613520B2 (en) | 2004-10-21 | 2009-11-03 | Advanced Neuromodulation Systems, Inc. | Spinal cord stimulation to treat auditory dysfunction |
US8260426B2 (en) | 2008-01-25 | 2012-09-04 | Cyberonics, Inc. | Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device |
WO2006087712A2 (en) | 2005-02-17 | 2006-08-24 | Metacure N.V. | Charger with data transfer capabilities |
US7774069B2 (en) * | 2005-04-29 | 2010-08-10 | Medtronic, Inc. | Alignment indication for transcutaneous energy transfer |
US7561923B2 (en) | 2005-05-09 | 2009-07-14 | Cardiac Pacemakers, Inc. | Method and apparatus for controlling autonomic balance using neural stimulation |
US20070016262A1 (en) | 2005-07-13 | 2007-01-18 | Betastim, Ltd. | Gi and pancreatic device for treating obesity and diabetes |
DE602006013995D1 (en) * | 2005-07-27 | 2010-06-10 | Qualcomm Inc | SYSTEM AND METHOD FOR ONLY A FORWARD TRANSFER BIT TRANSFER LAYER |
US20070027484A1 (en) | 2005-07-28 | 2007-02-01 | Cyberonics, Inc. | Autonomic nerve stimulation to treat a pancreatic disorder |
US7822486B2 (en) | 2005-08-17 | 2010-10-26 | Enteromedics Inc. | Custom sized neural electrodes |
US7551960B2 (en) * | 2005-09-08 | 2009-06-23 | Medtronic, Inc. | External presentation of electrical stimulation parameters |
US7620455B2 (en) | 2005-10-25 | 2009-11-17 | Cyberonics, Inc. | Cranial nerve stimulation to treat eating disorders |
US8041428B2 (en) | 2006-02-10 | 2011-10-18 | Electrocore Llc | Electrical stimulation treatment of hypotension |
EP1981584B1 (en) | 2006-02-03 | 2015-05-13 | Interventional Autonomics Corporation | Intravascular device for neuromodulation |
US20070191912A1 (en) * | 2006-02-10 | 2007-08-16 | Vision Quest Industries, Inc. | Interactive electrical stimulator device and server-based support system |
EP1984064A4 (en) | 2006-02-10 | 2009-11-11 | Electrocore Inc | Methods and apparatus for treating anaphylaxis using electrical modulation |
US20070233204A1 (en) * | 2006-02-16 | 2007-10-04 | Lima Marcelo G | RFID-based apparatus, system, and method for therapeutic treatment of a patient |
US8187297B2 (en) | 2006-04-19 | 2012-05-29 | Vibsynt, Inc. | Devices and methods for treatment of obesity |
US8160709B2 (en) | 2006-05-18 | 2012-04-17 | Endostim, Inc. | Use of electrical stimulation of the lower esophageal sphincter to modulate lower esophageal sphincter pressure |
US8068918B2 (en) | 2007-03-09 | 2011-11-29 | Enteromedics Inc. | Remote monitoring and control of implantable devices |
US20080300657A1 (en) | 2007-05-31 | 2008-12-04 | Mark Raymond Stultz | Therapy system |
EP2254462B1 (en) | 2007-11-12 | 2015-05-20 | Daniel J. Dilorenzo | Apparatus for programming of autonomic neuromodulation for the treatment of obesity |
US20120053653A1 (en) | 2009-05-08 | 2012-03-01 | Universite Libre De Bruxelles | Gastrointestinal device |
US9089708B2 (en) | 2010-05-27 | 2015-07-28 | Ndi Medical, Llc | Waveform shapes for treating neurological disorders optimized for energy efficiency |
AU2011282294B9 (en) | 2010-07-19 | 2014-09-25 | Cardiac Pacemakers, Inc. | Minimally invasive lead system for vagus nerve stimulation |
WO2012044472A2 (en) | 2010-10-01 | 2012-04-05 | Indiana University Research & Technology Corporation | Long term vagal nerve stimulation for therapeutic and diagnostic treatment |
US9474482B2 (en) | 2010-11-01 | 2016-10-25 | G-Tech Medical, Inc. | Method for diagnosis and treatment of disorders of the gastrointestinal tract, and apparatus for use therewith |
EP2635344B1 (en) | 2010-11-03 | 2015-07-08 | The Cleveland Clinic Foundation | Apparatus for energy efficient stimulation |
-
2003
- 2003-02-03 US US10/358,093 patent/US20040172084A1/en not_active Abandoned
- 2003-09-29 US US10/675,818 patent/US20040176812A1/en not_active Abandoned
- 2003-09-29 US US10/674,330 patent/US7489969B2/en not_active Expired - Fee Related
- 2003-09-29 US US10/674,324 patent/US20040172085A1/en not_active Abandoned
-
2004
- 2004-01-30 AT AT04707122T patent/ATE547148T1/en active
- 2004-01-30 AT AT04707111T patent/ATE537871T1/en active
- 2004-01-30 EP EP11165936A patent/EP2366425A1/en not_active Withdrawn
- 2004-01-30 DK DK04707122.0T patent/DK1601414T3/en active
-
2006
- 2006-06-09 US US11/450,202 patent/US20060229685A1/en not_active Abandoned
-
2007
- 2007-08-13 US US11/891,770 patent/US7729771B2/en not_active Expired - Lifetime
-
2009
- 2009-12-08 AU AU2009245845A patent/AU2009245845B2/en not_active Ceased
-
2010
- 2010-03-11 US US12/721,603 patent/US8010204B2/en not_active Expired - Fee Related
-
2011
- 2011-07-21 US US13/188,293 patent/US8538542B2/en not_active Expired - Fee Related
-
2013
- 2013-09-05 US US14/019,126 patent/US9174040B2/en not_active Expired - Fee Related
-
2015
- 2015-11-02 US US14/930,233 patent/US9682233B2/en not_active Expired - Fee Related
-
2017
- 2017-06-16 US US15/625,755 patent/US20170304615A1/en not_active Abandoned
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3128760A (en) * | 1961-08-21 | 1964-04-14 | Winston Electronics Ltd | Vagotomy test apparatus |
US4114625A (en) * | 1976-12-02 | 1978-09-19 | Onat Mustafa V | Anti-vomiting, anti-aspirating oral-nasal gastric tube |
US4198963A (en) * | 1978-10-19 | 1980-04-22 | Michigan Instruments, Inc. | Cardiopulmonary resuscitator, defibrillator and monitor |
US4867164A (en) * | 1983-09-14 | 1989-09-19 | Jacob Zabara | Neurocybernetic prosthesis |
US5025807A (en) * | 1983-09-14 | 1991-06-25 | Jacob Zabara | Neurocybernetic prosthesis |
US5236480A (en) * | 1989-01-05 | 1993-08-17 | Camfil Ab | Air filter for workstations and methods of making and using such air filter |
US5226426A (en) * | 1990-12-18 | 1993-07-13 | Inbae Yoon | Safety penetrating instrument |
US5188104A (en) * | 1991-02-01 | 1993-02-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
US5199430A (en) * | 1991-03-11 | 1993-04-06 | Case Western Reserve University | Micturitional assist device |
US5299569A (en) * | 1991-05-03 | 1994-04-05 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by nerve stimulation |
US5215086A (en) * | 1991-05-03 | 1993-06-01 | Cyberonics, Inc. | Therapeutic treatment of migraine symptoms by stimulation |
US5335657A (en) * | 1991-05-03 | 1994-08-09 | Cyberonics, Inc. | Therapeutic treatment of sleep disorder by nerve stimulation |
US5226429A (en) * | 1991-06-20 | 1993-07-13 | Inamed Development Co. | Laparoscopic gastric band and method |
US5231988A (en) * | 1991-08-09 | 1993-08-03 | Cyberonics, Inc. | Treatment of endocrine disorders by nerve stimulation |
US5423872A (en) * | 1992-05-29 | 1995-06-13 | Cigaina; Valerio | Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient |
US5330515A (en) * | 1992-06-17 | 1994-07-19 | Cyberonics, Inc. | Treatment of pain by vagal afferent stimulation |
US5292344A (en) * | 1992-07-10 | 1994-03-08 | Douglas Donald D | Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system, with optional delivery port |
US5344438A (en) * | 1993-04-16 | 1994-09-06 | Medtronic, Inc. | Cuff electrode |
US5601604A (en) * | 1993-05-27 | 1997-02-11 | Inamed Development Co. | Universal gastric band |
US5620955A (en) * | 1993-06-18 | 1997-04-15 | Peptide Technologies Corporation | Bombesin receptor antagonists and uses thereof |
US5437291A (en) * | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
US6290961B1 (en) * | 1993-12-28 | 2001-09-18 | Allergan, Inc. | Method for treating dystonia with botulinum toxin type B |
US6405732B1 (en) * | 1994-06-24 | 2002-06-18 | Curon Medical, Inc. | Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors |
US5514175A (en) * | 1994-11-09 | 1996-05-07 | Cerebral Stimulation, Inc. | Auricular electrical stimulator |
US6558708B1 (en) * | 1995-05-17 | 2003-05-06 | Cedars-Sinai Medical Center | Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia |
US5540730A (en) * | 1995-06-06 | 1996-07-30 | Cyberonics, Inc. | Treatment of motility disorders by nerve stimulation |
US20020055779A1 (en) * | 1996-03-05 | 2002-05-09 | Brian J. Andrews | Neural prosthesis |
US5747060A (en) * | 1996-03-26 | 1998-05-05 | Euro-Celtique, S.A. | Prolonged local anesthesia with colchicine |
US6532388B1 (en) * | 1996-04-30 | 2003-03-11 | Medtronic, Inc. | Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure |
US20020032468A1 (en) * | 1996-04-30 | 2002-03-14 | Hill Michael R.S. | Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure |
US6243607B1 (en) * | 1996-09-05 | 2001-06-05 | University Technologies International Inc. | Gastro-intestinal electrical pacemaker |
US5716385A (en) * | 1996-11-12 | 1998-02-10 | University Of Virginia | Crural diaphragm pacemaker and method for treating esophageal reflux disease |
US6238423B1 (en) * | 1997-01-13 | 2001-05-29 | Medtronic, Inc. | Apparatus and method for treating chronic constipation |
US6111715A (en) * | 1997-01-13 | 2000-08-29 | Hitachi, Ltd. | Storage apparatus using a magnetoresistive head that employs a sense current selected from plural predetermined sense currents |
US5861014A (en) * | 1997-04-30 | 1999-01-19 | Medtronic, Inc. | Method and apparatus for sensing a stimulating gastrointestinal tract on-demand |
US6083249A (en) * | 1997-04-30 | 2000-07-04 | Medtronic, Inc. | Apparatus for sensing and stimulating gastrointestinal tract on-demand |
US6216039B1 (en) * | 1997-05-02 | 2001-04-10 | Medtronic Inc. | Method and apparatus for treating irregular gastric rhythms |
US6093167A (en) * | 1997-06-16 | 2000-07-25 | Medtronic, Inc. | System for pancreatic stimulation and glucose measurement |
US5919216A (en) * | 1997-06-16 | 1999-07-06 | Medtronic, Inc. | System and method for enhancement of glucose production by stimulation of pancreatic beta cells |
US6571127B1 (en) * | 1997-07-16 | 2003-05-27 | Impulse Dynamics N.V. | Method of increasing the motility of a GI tract |
US20040059383A1 (en) * | 1997-08-26 | 2004-03-25 | Puskas John D. | Methods of indirectly stimulating the vagus nerve with an electrical field |
US20050143412A1 (en) * | 1997-08-26 | 2005-06-30 | Puskas John D. | Methods of indirectly stimulating the vagus nerve with an electrical field |
US6104955A (en) * | 1997-12-15 | 2000-08-15 | Medtronic, Inc. | Method and apparatus for electrical stimulation of the gastrointestinal tract |
US6091992A (en) * | 1997-12-15 | 2000-07-18 | Medtronic, Inc. | Method and apparatus for electrical stimulation of the gastrointestinal tract |
US6364899B1 (en) * | 1998-01-23 | 2002-04-02 | Innercool Therapies, Inc. | Heat pipe nerve cooler |
US20040089313A1 (en) * | 1998-02-19 | 2004-05-13 | Curon Medical, Inc. | Systems and methods for treating obesity and other gastrointestinal conditions |
US6369079B1 (en) * | 1998-06-15 | 2002-04-09 | Sepracor, Inc. | Methods for treating irritable bowel syndrome using optically pure (+) norcisapride |
US20020012828A1 (en) * | 1998-09-07 | 2002-01-31 | Bojidara Grigorova | Fuel cell and gold-containing catalyst for use therein |
US6292703B1 (en) * | 1998-10-08 | 2001-09-18 | Biotronik Mess-Und Therapiegerate Gmbh & Co. | Neural electrode arrangement |
US6611715B1 (en) * | 1998-10-26 | 2003-08-26 | Birinder R. Boveja | Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator |
US20050137644A1 (en) * | 1998-10-26 | 2005-06-23 | Boveja Birinder R. | Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders |
US6097984A (en) * | 1998-11-25 | 2000-08-01 | Medtronic, Inc. | System and method of stimulation for treating gastro-esophageal reflux disease |
US20020052336A1 (en) * | 1999-02-26 | 2002-05-02 | Yerxa Benjamin R. | Method of treating gastrointestinal tract disease with purinergic receptor agonists |
US6261280B1 (en) * | 1999-03-22 | 2001-07-17 | Medtronic, Inc | Method of obtaining a measure of blood glucose |
US6098629A (en) * | 1999-04-07 | 2000-08-08 | Endonetics, Inc. | Submucosal esophageal bulking device |
US6895278B1 (en) * | 1999-04-14 | 2005-05-17 | Transneuronix, Inc. | Gastric stimulator apparatus and method for use |
US6341236B1 (en) * | 1999-04-30 | 2002-01-22 | Ivan Osorio | Vagal nerve stimulation techniques for treatment of epileptic seizures |
US7072720B2 (en) * | 1999-06-25 | 2006-07-04 | Emory University | Devices and methods for vagus nerve stimulation |
US20030074039A1 (en) * | 1999-06-25 | 2003-04-17 | Puskas John D. | Devices and methods for vagus nerve stimulation |
US6587719B1 (en) * | 1999-07-01 | 2003-07-01 | Cyberonics, Inc. | Treatment of obesity by bilateral vagus nerve stimulation |
US6853862B1 (en) * | 1999-12-03 | 2005-02-08 | Medtronic, Inc. | Gastroelectric stimulation for influencing pancreatic secretions |
US6610713B2 (en) * | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
US20020072780A1 (en) * | 2000-09-26 | 2002-06-13 | Transneuronix, Inc. | Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity |
US6591137B1 (en) * | 2000-11-09 | 2003-07-08 | Neuropace, Inc. | Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders |
US20020094962A1 (en) * | 2000-12-01 | 2002-07-18 | Gary Ashley | Motilide compounds |
US6993391B2 (en) * | 2000-12-11 | 2006-01-31 | Metacure N.V. | Acute and chronic electrical signal therapy for obesity |
US6609025B2 (en) * | 2001-01-02 | 2003-08-19 | Cyberonics, Inc. | Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation |
US20020087192A1 (en) * | 2001-01-02 | 2002-07-04 | Barrett Burke T. | Treatment of obesity by sub-diaphragmatic nerve stimulation |
US20020103424A1 (en) * | 2001-01-31 | 2002-08-01 | Swoyer John M. | Implantable medical device affixed internally within the gastrointestinal tract |
US20040127953A1 (en) * | 2001-02-20 | 2004-07-01 | Kilgore Kevin L. | Systems and methods for reversibly blocking nerve activity |
US6928320B2 (en) * | 2001-05-17 | 2005-08-09 | Medtronic, Inc. | Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated |
US20050149148A1 (en) * | 2001-05-17 | 2005-07-07 | Medtronic, Inc. | Apparatus and method for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated |
US20030014086A1 (en) * | 2001-07-14 | 2003-01-16 | Sharma Virender K. | Method and apparatus for electrical stimulation of the lower esophageal sphincter |
US20030018367A1 (en) * | 2001-07-23 | 2003-01-23 | Dilorenzo Daniel John | Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease |
US20030040785A1 (en) * | 2001-08-21 | 2003-02-27 | Maschino Steve E. | Circumneural electrode assembly |
US20030045909A1 (en) * | 2001-08-31 | 2003-03-06 | Biocontrol Medical Ltd. | Selective nerve fiber stimulation for treating heart conditions |
US6684105B2 (en) * | 2001-08-31 | 2004-01-27 | Biocontrol Medical, Ltd. | Treatment of disorders by unidirectional nerve stimulation |
US20030045914A1 (en) * | 2001-08-31 | 2003-03-06 | Biocontrol Medical Ltd. | Treatment of disorders by unidirectional nerve stimulation |
US20030144709A1 (en) * | 2002-01-25 | 2003-07-31 | Cyberonics, Inc. | Nerve stimulation as a treatment for pain |
US7076307B2 (en) * | 2002-05-09 | 2006-07-11 | Boveja Birinder R | Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders |
US20050143787A1 (en) * | 2002-05-09 | 2005-06-30 | Boveja Birinder R. | Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator |
US20050149146A1 (en) * | 2002-05-09 | 2005-07-07 | Boveja Birinder R. | Method and system to provide therapy for obesity and other medical disorders, by providing electrical pules to symapthetic nerves or vagal nerve(s) with rechargeable implanted pulse generator |
US20040039425A1 (en) * | 2002-05-29 | 2004-02-26 | Beverley Greenwood-Van Meerveld | Spinal cord stimulation as treatment for functional bowel disorders |
US6746474B2 (en) * | 2002-05-31 | 2004-06-08 | Vahid Saadat | Apparatus and methods for cooling a region within the body |
US20040086531A1 (en) * | 2002-11-05 | 2004-05-06 | Allergan, Inc. | Methods for treating ulcers and gastroesophageal reflux disease |
US20050131485A1 (en) * | 2003-02-03 | 2005-06-16 | Enteromedics, Inc. | High frequency vagal blockage therapy |
US7167750B2 (en) * | 2003-02-03 | 2007-01-23 | Enteromedics, Inc. | Obesity treatment with electrically induced vagal down regulation |
US20050038484A1 (en) * | 2003-02-03 | 2005-02-17 | Enteromedics, Inc. | Controlled vagal blockage therapy |
US20040167583A1 (en) * | 2003-02-03 | 2004-08-26 | Enteromedics, Inc. | Electrode band apparatus and method |
US20060015151A1 (en) * | 2003-03-14 | 2006-01-19 | Aldrich William N | Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures |
US20050049655A1 (en) * | 2003-08-27 | 2005-03-03 | Boveja Birinder R. | System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities |
US20050070974A1 (en) * | 2003-09-29 | 2005-03-31 | Knudson Mark B. | Obesity and eating disorder stimulation treatment with neural block |
US20050070970A1 (en) * | 2003-09-29 | 2005-03-31 | Knudson Mark B. | Movement disorder stimulation with neural block |
US20050075693A1 (en) * | 2003-10-02 | 2005-04-07 | Medtronic, Inc. | Driver circuitry switchable between energy transfer and telemetry for an implantable medical device |
US7054690B2 (en) * | 2003-10-22 | 2006-05-30 | Intrapace, Inc. | Gastrointestinal stimulation device |
US20050143378A1 (en) * | 2003-12-29 | 2005-06-30 | Yun Anthony J. | Treatment of conditions through pharmacological modulation of the autonomic nervous system |
US20050149141A1 (en) * | 2004-01-07 | 2005-07-07 | Starkebaum Warren L. | Gastric stimulation for altered perception to treat obesity |
US20060036293A1 (en) * | 2004-08-16 | 2006-02-16 | Whitehurst Todd K | Methods for treating gastrointestinal disorders |
US20070043400A1 (en) * | 2005-08-17 | 2007-02-22 | Donders Adrianus P | Neural electrode treatment |
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9586046B2 (en) | 2003-02-03 | 2017-03-07 | Enteromedics, Inc. | Electrode band system and methods of using the system to treat obesity |
US9682233B2 (en) | 2003-02-03 | 2017-06-20 | Enteromedics Inc. | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US8538533B2 (en) | 2003-02-03 | 2013-09-17 | Enteromedics Inc. | Controlled vagal blockage therapy |
US9174040B2 (en) | 2003-02-03 | 2015-11-03 | Enteromedics Inc. | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US7693577B2 (en) | 2003-02-03 | 2010-04-06 | Enteromedics Inc. | Irritable bowel syndrome treatment |
US7720540B2 (en) | 2003-02-03 | 2010-05-18 | Enteromedics, Inc. | Pancreatitis treatment |
US7729771B2 (en) | 2003-02-03 | 2010-06-01 | Enteromedics Inc. | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US9162062B2 (en) | 2003-02-03 | 2015-10-20 | Enteromedics Inc. | Controlled vagal blockage therapy |
US7844338B2 (en) | 2003-02-03 | 2010-11-30 | Enteromedics Inc. | High frequency obesity treatment |
US8010204B2 (en) | 2003-02-03 | 2011-08-30 | Enteromedics Inc. | Nerve blocking for treatment of gastrointestinal disorders |
US8046085B2 (en) | 2003-02-03 | 2011-10-25 | Enteromedics Inc. | Controlled vagal blockage therapy |
US8538542B2 (en) | 2003-02-03 | 2013-09-17 | Enteromedics Inc. | Nerve stimulation and blocking for treatment of gastrointestinal disorders |
US8103349B2 (en) | 2005-08-17 | 2012-01-24 | Enteromedics Inc. | Neural electrode treatment |
US7672727B2 (en) | 2005-08-17 | 2010-03-02 | Enteromedics Inc. | Neural electrode treatment |
US11413296B2 (en) | 2005-11-12 | 2022-08-16 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US20080281365A1 (en) * | 2007-05-09 | 2008-11-13 | Tweden Katherine S | Neural signal duty cycle |
US20180325921A1 (en) * | 2007-11-13 | 2018-11-15 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
US20160235769A1 (en) * | 2007-11-13 | 2016-08-18 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
US9186502B2 (en) | 2008-02-14 | 2015-11-17 | Enteromedics Inc. | Treatment of excess weight by neural downregulation in combination with compositions |
US20090210019A1 (en) * | 2008-02-14 | 2009-08-20 | Dennis Dong-Won Kim | Treatment of excess weight by neural downregulation in combination with compositions |
US9974955B2 (en) | 2008-04-04 | 2018-05-22 | Reshape Lifesciences Inc. | Methods and systems for glucose regulation |
US20090254143A1 (en) * | 2008-04-04 | 2009-10-08 | Tweden Katherine S | Methods and systems for glucose regulation |
US10722714B2 (en) | 2008-04-04 | 2020-07-28 | Reshape Lifesciences, Inc. | Methods and systems for glucose regulation |
US8483830B2 (en) | 2008-04-04 | 2013-07-09 | Enteromedics Inc. | Methods and systems for glucose regulation |
US8825164B2 (en) | 2010-06-11 | 2014-09-02 | Enteromedics Inc. | Neural modulation devices and methods |
US9358395B2 (en) | 2010-06-11 | 2016-06-07 | Enteromedics Inc. | Neural modulation devices and methods |
US9968778B2 (en) | 2010-06-11 | 2018-05-15 | Reshape Lifesciences Inc. | Neural modulation devices and methods |
Also Published As
Publication number | Publication date |
---|---|
US8538542B2 (en) | 2013-09-17 |
EP2366425A1 (en) | 2011-09-21 |
US20040172085A1 (en) | 2004-09-02 |
US20040176812A1 (en) | 2004-09-09 |
US7489969B2 (en) | 2009-02-10 |
US20040172084A1 (en) | 2004-09-02 |
US9682233B2 (en) | 2017-06-20 |
US20170304615A1 (en) | 2017-10-26 |
DK1601414T3 (en) | 2012-05-29 |
US20080021512A1 (en) | 2008-01-24 |
US9174040B2 (en) | 2015-11-03 |
US20140172052A1 (en) | 2014-06-19 |
US8010204B2 (en) | 2011-08-30 |
US7729771B2 (en) | 2010-06-01 |
AU2009245845B2 (en) | 2011-09-29 |
US20160193465A1 (en) | 2016-07-07 |
US20040172086A1 (en) | 2004-09-02 |
AU2009245845A1 (en) | 2010-01-07 |
ATE547148T1 (en) | 2012-03-15 |
US20100168815A1 (en) | 2010-07-01 |
ATE537871T1 (en) | 2012-01-15 |
US20110282411A1 (en) | 2011-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20060229685A1 (en) | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) | |
EP1601414B1 (en) | Apparatus for neural stimulation | |
US7937144B2 (en) | Electric modulation of sympathetic nervous system | |
US9037244B2 (en) | Method and apparatus for electrical stimulation of the pancreatico-biliary system | |
US7236822B2 (en) | Wireless electric modulation of sympathetic nervous system | |
US7689276B2 (en) | Dynamic nerve stimulation for treatment of disorders | |
US7702386B2 (en) | Nerve stimulation for treatment of obesity, metabolic syndrome, and Type 2 diabetes | |
US8295926B2 (en) | Dynamic nerve stimulation in combination with other eating disorder treatment modalities | |
US20080262411A1 (en) | Dynamic nerve stimulation in combination with other eating disorder treatment modalities | |
CA2639996A1 (en) | Nerve stimulation for treatment of obesity, type 2 diabetes, and metabolic syndrome | |
Mizrahi et al. | Gastric stimulation for weight loss |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: RESHAPE LIFESCIENCES INC., CALIFORNIA Free format text: CHANGE OF NAME;ASSIGNOR:ENTEROMEDICS INC.;REEL/FRAME:045949/0495 Effective date: 20171012 |