US20050203433A1 - Methods of organ vitality assessment - Google Patents
Methods of organ vitality assessment Download PDFInfo
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- US20050203433A1 US20050203433A1 US10/908,625 US90862505A US2005203433A1 US 20050203433 A1 US20050203433 A1 US 20050203433A1 US 90862505 A US90862505 A US 90862505A US 2005203433 A1 US2005203433 A1 US 2005203433A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4869—Determining body composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0537—Measuring body composition by impedance, e.g. tissue hydration or fat content
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/416—Evaluating particular organs or parts of the immune or lymphatic systems the spleen
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
Definitions
- the present invention relates to the method which incorporates the utilization of bioelectrical impedance analysis (BIA) in a biological model for body composition analysis (BCA) to provide an objective assessment of an organ's and/or biological entity's volume and distribution of fluids and tissue as well as the electrical health of cells and membranes.
- BIOA bioelectrical impedance analysis
- BCA body composition analysis
- Another aspect of the present invention relates to a method of organ vitality assessment for various purposes, including transplantation of said organ being assessed.
- biological entity means: “any and all human beings, animals and/or living organisms.”
- non-acute death means: “any death that does not occur acutely; it occurs more than four days (96 hours) from a precipitous event or illness; it is the end-point of a process whose duration exceeds the four-day reference; unlike that death resulting from a proximate, immediate or acute event, a ‘non-acute death’ occurs over time.”
- a desideratum of the present invention is to avoid the animadversions of conventional methods and techniques, and to provide a novel method of organ vitality assessment for transplantation and/or xenotransplantation and for other purposes of said organ being assessed.
- the present invention provides a method of organ vitality assessment, comprising the steps of: utilizing bioelectric impedance analysis in a biological model for body composition analysis; and using the results of said utilizing step to provide an objective assessment of volume and distribution of fluid and tissues, as well as electrical health of cells and membranes of said organ.
- the present invention also provides a method of organ vitality assessment, comprising the steps of: placing signal introduction electrodes on opposite lateral peripheral borders of said organ; placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement of said organ; measuring and recording first values of resistance and reactance of said organ in said initial measurement; then placing said signal introduction electrodes on said superior and said inferior borders of said organ; placing said signal detection electrodes on said opposite lateral borders of said organ; measuring and recording second values of said resistance and said reactance of said organ; and comparing said first and second values to normal values to assess vitality of said organ.
- the present invention further provides a method of organ vitality assessment for transplantation of said organ being assessed, comprising the steps of: placing signal introduction electrodes on opposite lateral peripheral borders of said organ upon harvesting of said organ; placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement upon said harvesting of said organ; measuring and recording first values of resistance and reactance of said organ in said initial measurement; then placing said signal introduction electrodes on said superior and said inferior borders of said organ; placing said signal detection electrodes on said opposite lateral borders of said organ; measuring and recording second values of said resistance and said reactance of said organ; and comparing said first and second values to normal values to determine if said organ is acceptable or not for said transplantation.
- FIG. 1 is a schematic illustration of one embodiment of the present invention.
- FIG. 2 illustrates how electrodes may be placed on a hand for the BIA testing procedure.
- FIG. 3 illustrates how the electrodes may be placed on the foot for the BIA testing.
- BIA is an electrodiagnostic methodology based upon the conductive properties of the body's tissues, cells, and fluids.
- the BIA instrument such as that disclosed in U.S. Pat. No. 5,372,141, an impedance plethysmograph, may use a constant current source producing a low-voltage electrical signal, usually 800 micro-amps at a high frequency, often fixed at 50 KHz, to set up an electrical field in the whole body or a body segment using a pair of surface ECG-type electrodes.
- the methods of the present invention can utilize a modification of the body composition analyzer disclosed in U.S. Pat. No. 5,372,141, the entire contents of which are incorporated herein by reference thereto.
- utilization of BIA in a biological model for BCA provides an objective assessment of the study subject's (whole body or organ) volume and distribution of fluids and tissues, as well as the electrical health of the cells and membranes.
- BIA The characteristics of BIA include precision, accuracy, feasibility and economy. BIA may be applied to any area of interest, regionally or to the whole body. It is non-offensive, causing no harm. It may be repeated freely, as desired, to illustrate change over time so that progression of conditions can be monitored and intervention modified.
- One aspect of the present invention applies the BIA technology for BCA assessment of vitality of organs for transplant, vitality of organs from other species for human transplantation (xenotransplantation), and to monitor and assess the timing of death.
- Organ vitality assessment is based upon the ability of a modified BIA for BCA to illustrate the health of cells by the measured reactance (X).
- signal introduction electrodes are placed on the opposite lateral peripheral borders of the organ being assessed, and signal detection electrodes are placed at the superior and inferior borders of the organ being assessed for the first part of the initial
- the values of electrical resistance (R) and impedance (X) are measured and recorded.
- the signal introduction electrodes are then re-positioned or placed on the superior and inferior borders of the organ being assessed, while the signal detection electrodes are now re-positioned or placed the opposite lateral peripheral borders of the organ being assessed.
- the values are then compared to normal values, and the organ is determined to be acceptable or not.
- the values should be within an acceptable range of agreement denoting no further loss of organ vitality, and then the implantation is completed.
- the uncorrectable loss of cell mass and membrane capacity as evidenced by a reduction in X and f or by an uncorrectable and increasing disparity of ECW (extracellular water) volume being greater than ICW (intracellular water) volume and remaining uncorrectable, are the hallmarks of the progression to the death of the biological entity.
- One embodiment of the present invention provides a method for determining illness of a biological entity, progression to death of said biological entity, and/or timing of death of said biological entity, comprising the steps of: taking whole body measurements of resistance, reactance, phase angle, extracellular water volume, and intracellular water volume at predetermined intervals of time; recording said whole body measurements; comparing initial values of said whole body measurements to normal values of said whole body measurements and to serially measured values of said whole body measurements; and determining from said comparison step hallmarks of said illness of said biological entity, said progression to said death of said biological entity, and/or said death of said biological entity.
- Another embodiment of the present invention provides a method of organ vitality assessment for transplantation of said organ being assessed, comprising the steps of: placing signal introduction electrodes on opposite lateral peripheral borders of said organ upon harvesting of said organ; placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement upon said harvesting of said organ; measuring and recording first values of resistance and reactance of said organ in said initial measurement; then placing said signal introduction electrodes on said superior and said inferior borders of said organ; placing said signal detection electrodes on said opposite lateral borders of said organ; measuring and recording second values of said resistance and said reactance of said organ; and comparing said first and second values to normal values to determine if said organ is acceptable or not for said transplantation.
- the preferred embodiment provides a method and apparatus for use in detecting the presence and severity of illness, the effectiveness of treatment interventions, and the ability to change treatment to be more effective or aggressive; to optimize outcome, limit morbidity and mortality and illustrate the patient's prognosis.
- the purpose of the preferred embodiment is to empower the healthcare provider and the patient by detecting and characterizing the presence and nature of illness and injury to include episodic, serious, and non-episodic illness and injury, its progression, and the effectiveness of treatment interventions and the prognosis of the patient.
- This system employs the use of Whole Body Impedance Analysis to measure the patient's Resistance, Reactance, Phase Angle, and related electrical values at a healthy baseline, and thereafter in relation to the patient's complaints to evaluate the temporal or progressive nature of negative values or diminution of the measured values over time.
- the system identifies the patient's healthy baseline measured electrical values and, during routine health examinations or when the patient complains of any symptoms or experiences any signs of illness or injury, illustrates excursion from the baseline values that may exceed a thirty-day time frame or progressively diminish.
- Episodic illness and recoverable injury is characterized by a brief, less than thirty days, excursion below the baseline values and return to the baseline values. More severe illness and injury are characterized by progressive or rapid diminution of the measured values.
- the measured values will stabilize and then return to the baseline values indicative of the patient's positive prognosis. More effective treatment is indicated by a more rapid return to baseline-measured values. If the values do not improve, a modified or more aggressive treatment intervention is indicated whose positive effectiveness will be indicated by the initial stabilization of the measured values and their subsequent return to baseline values.
- Prognosis is proportional to the speed and direction of the return of the measured value to or from the baseline values.
- a positive prognosis is indicated by a progressive and/or rapid return to the measure baseline values.
- a negative prognosis is indicated by a progressive and/or rapid diminution of the measured values.
- the speed of loss or gain of the measured values is proportional to the return of health or the severity of the illness or injury.
- Frequency of measurements is in proportion to the severity of the process to be illustrated; more severe illness or injury, characterized by more severe symptoms, signs and negative laboratory findings and progressive and/or rapid diminution of the measured values, require more frequent measurements, daily and every other day. Less severe illnesses and injuries may be illustrated with weekly measurements.
- the patient is counseled to lie quietly, motionless, and informed that the test will take less than five minutes if the patent is cooperative.
- the patient is generally placed in a supine position with arms and legs abducted about thirty degrees from the midline on a dry non-conductive surface.
- Whole Body 1 and Regional 2 studies require a tetrapolar electrode scheme in which placement of four (two pairs) surface, ECG electrodes in strict relation to anatomical landmarks at the wrist and ankle. If the patient's skin is either too dry or too oily, wiping the electrode placement area with an alcohol prep wipe is suggested.
- the right side of the body is generally used with the electrodes placed ipsilaterally.
- the signal detection (SD) electrodes 3 or 4 must be placed with the greatest precision in relation to known anatomical landmarks on both the wrist and the ankle.
- the signal introduction (SI) electrodes 5 are placed distal from the SD electrodes 3 and must be kept at a minimum distance that equals or exceeds that of the diameter of the segment being measured (e.g., the wrist). This is most easily and efficiently accomplished by using the distal phalanx of the middle finger, just proximal to the nail.
- the SD electrode 4 is placed so that the superior linear border equally bisects the medial malleolous (the bump on the big toe side of the ankle) with the tab facing outwards from the patient. Care should be exercised to use the medical malleolous because the lateral malleolous (the bump on the little toe side of the ankle) is inferior or below the medial malleolous landmark.
- the SI electrode 6 is placed on the big toe, as shown in FIG. 1 .
- the plethysmograph is connected via patient cable leads with strict attention paid to SI and SD leads connected to SI and SD electrodes.
- the device is energized and the values of resistance and reactance in ohms, are measured individually, allowing a moment (ten to fifteen seconds) to settle, and then are recorded.
- the electrodes are carefully removed so as not to injure friable skin or contaminate the examiner.
- any standard impedance plethysmograph that utilizes a 500-800 micro-amp constant current electrical source at 50-kilohertz frequency can be utilized.
- an RJL Systems, Inc. manufactured Quantum II instrument system may be used for both Whole Body 1 and Regional 2 measurements.
- the patient is prepared in the same manner as with a Whole-Body 1 examination.
- the signal detection electrodes 7 are placed superiorly and inferiorly in precise relation to the area of interest. The distance between the detection electrodes is precisely measured and recorded in centimeters.
- the skin is marked with a surgical pen to assure accurate and reproducible electrode placement for serial measurements.
- the SI electrodes 1 are best placed in the standard Whole-Body locations, however this requires a specialized patient cable with adequate distance or throw, about eighteen inches of length allowed, between the insertion point into the patient cable to and from the clip ends.
- the impedance plethysmograph is connected via the patient cables with strict adherence to the SD lead to the SD electrode and the SI lead to the SI electrode. The measured values are recorded and the electrodes carefully removed.
- the measured values, resistance, reactance and phase angle are recorded, archived and graphically presented to illustrate change over time and illuminate the processes of disease progression and response to treatment.
- the frequency of serial measurements is proportional to the dynamic of the event to be captured. If at all possible, a baseline study value is particularly desirable.
- ohms Disorders characterized by dynamic shifts of extracellular fluid volumes require more frequent measurements, often prior to and after a procedure or treatment such as a patient requiring hemodialysis, aggressive diuresis in organ failure or repletion of fluids in acute dehydration or trauma.
- the measured resistance value in ohms is inversely proportional to the extracellular fluid volume of the patient. When resistance ohms decrease fluid has increased and conversely when resistance ohms increase fluid volume has decreased. So, once an initial ohm measurement value is established by baseline or first study, subsequent measurements illustrate the patient's course and response to disease progression and the effectiveness of the selected treatment intervention. The severity of the disease or insult condition evidenced by the speed of the excursion from baseline or initial measurement value.
- Fluid changes that move more than fifty ohms in a twenty-four hour period are severe and indicate a more acute and serious condition than those that move fifty ohms in a week's time indicative of a more chronic condition. Both conditions require intervention, however as chronic insidious changes are as adverse to survival as more rapid changes.
- Whole Body 1 measurements are more general in their value, indicative of conditions and events that encompass the organism as a whole such as cardiac or renal failure and acute dehydration.
- Regional 2 measurements provide a site-specific assessment of fluid volumes such as those found with pleural effusion in the chest, ascites in the abdomen or even cerebral edema. The changes of measured electrical values precede changes seen on x-ray, physical examination, or from laboratory studies.
- Reactance values are proportional to the number and integrity (health) of cell wall membranes so when cells increase or decrease reactance values follow.
- the cells that change in this manner are those of the somatic and visceral protein tissues, such as skeletal musculature organs such as the liver, spleen, lungs, heart stomach and intestines. Cellular alterations are generally slower to occur and are affected by metabolic and specific disease processes. However, overly aggressive diuresis, excessive hemodialysis or cellular targeted pathologies such as Rhabdomyolysis can all result in rapid, days versus a week, changes in cell mass, membrane status and measured reactance values. Excursions from the baseline or initial measurement value indicate the type and progression of disease and/or the effectiveness of treatment interventions.
- Increased cells (membranes) and anabolic metabolism are evidenced by a rise in the ohms of reactance, generally a sign of improvement.
- a slowly decreasing ohm value of reactance indicates a negative or catabolic metabolism condition.
- a more precipitous and rapid decrease in reactance is indicative of unique conditions that rapidly affect cells and their membranes, such as the effect of Rhabdomyolysis skeletal muscle or rejection or infection of an organ system.
- Phase Angle is the cumulative expression of the changes and ratios of cell mass and extracellular fluid that result from disease, insult and/or treatment intervention and can by itself be used to gauge the severity and progression of pathologies and the effectiveness and benefits of treatment.
- a positive prognosis is indicated by an increasing phase angle while a poor prognosis is associated with a phase angle decrease.
- Phase angle has been correlated with survival and the timing of non-acute death. Phase angle can be derived from both whole body and regional measurements and followed serially to establish prognosis.
- Treatment interventions can be measured for their effectiveness on the individual patient by following phase angle. More effective treatments are evidenced by an increasing phase angle while those less effective are seen as producing little or no increase. Once phase angle degrades to below four degrees, the patient is seriously ill and treatment should be aggressive and modified to be effective and optimal. If phase angle does not stabilize or increase through multiple iterations of treatment, a curative or restorative treatment goal outcome is doubtful. A phase angle of less than two degrees is associated with pending mortality and a need for palliative care and comfort. Admission to a hospice can be objectively based upon phase angle monitoring providing the patient with improved end-of-life care and comfort.
- FIG. 2 illustrates how electrodes may be placed on the hand for the BIA Testing Procedure.
- the detecting electrode edge 8 is placed on an imaginary line bisecting the ulna head (bone on little finger side of wrist).
- the signal electrode 9 is placed on the first joint of the middle finger.
- FIG. 3 illustrates how electrodes may be placed on the foot.
- the detecting electrode edge 10 is placed on an imaginary line bisecting the medial mellealus (bone on big toe side of ankle).
- the signal electrode 11 is placed on the base of the second toe.
- the exam area should be comfortable and free of drafts and portable electric heaters.
- the exam table surface must be non-conductive and large enough for the subject to line supine with the arms 30 degrees from the body, and legs not in contact with each other.
- the subject should not have exercised or taken a sauna within 18 hours of the study.
- the subject should refrain from alcohol intake for 12 hours prior to the study.
- the subject's height and weight should be accurately measured and recorded.
- the subject should lie quietly during the entire test.
- the subject should not be wet from sweat or urine.
- the subject should not have a fever or be in shock.
- the study and testing procedure should be explained to the subject.
- the subject should remove the shoe and sock and any jewelry on the electrode side (generally the study is completed on the right side of the body).
- the body side (left or right) should always be used subsequently.
- the subject should lie supine with the arms 30 degrees from the body with legs not touching.
- the electrode sites may be cleaned with alcohol, particularly if the skin is dry or covered with lotion.
- the electrodes and patient cables are attached as shown in FIGS. 2 and 3 .
- the analyzer is turned on, making sure the subject refrains from moving.
- R Resistance
- Xc Reactance
- the entire testing time is less than 5 minutes—the BIA analyzer is on for less than one minute.
- the study may be repeated as often as necessary.
- the present invention also embraces the features of using the invention for various areas of interest, for example, whole-body thoracic, abdominal, extremity, etc.
Abstract
A method of organ vitality assessment using bioelectric impedance analysis in a biological model for body composition analysis, and using the results to provide an objective assessment of volume and distribution of tissues, as well as electrical health of cells and membranes of an organ.
Description
- The present application is a divisional application of U.S. patent application Ser. 10/701,004 filed Nov. 4, 2003, which is based on and claims priority from U.S. Provisional Patent Application Ser. No. 60/424,828 filed Nov. 8, 2002, which in turn is a continuation-in-part of U.S. Pat. No. 6,587,715. The complete disclosure of the aforesaid applications and patent are incorporated herein by reference hereto.
- The present invention relates to the method which incorporates the utilization of bioelectrical impedance analysis (BIA) in a biological model for body composition analysis (BCA) to provide an objective assessment of an organ's and/or biological entity's volume and distribution of fluids and tissue as well as the electrical health of cells and membranes.
- Another aspect of the present invention relates to a method of organ vitality assessment for various purposes, including transplantation of said organ being assessed.
- The terms “biological entity”, “patient” and “subject” as used herein mean: “any and all human beings, animals and/or living organisms.”
- The term “non-acute death” as used herein means: “any death that does not occur acutely; it occurs more than four days (96 hours) from a precipitous event or illness; it is the end-point of a process whose duration exceeds the four-day reference; unlike that death resulting from a proximate, immediate or acute event, a ‘non-acute death’ occurs over time.”
- The prior, but not necessarily relevant, art is exemplified by:
- Bagno U.S. Pat. No. 2,111,135; Hanson U.S. Pat. No. 2,852,739; Tolles U.S. Pat. No. 3,085,566; Thomasset U.S. Pat. No. 3,316,896; Max et al. U.S. Pat. No. 3,498,288; Sigworth U.S. Pat. No. 3,882,851; Ghislaine et al. U.S. Pat. No. 4,823,804; Gallup et al. U.S. Pat. No. 5,372,141; Kotler U.S. Pat. No. 5,615,689; Brasile U.S. Pat. No. 6,024,698; Cherepenin et al. U.S. Pat. No. 6,236,866; and Kobayashi U.S. Patent Application Publication 2001/0023362.
- A desideratum of the present invention is to avoid the animadversions of conventional methods and techniques, and to provide a novel method of organ vitality assessment for transplantation and/or xenotransplantation and for other purposes of said organ being assessed.
- The present invention provides a method of organ vitality assessment, comprising the steps of: utilizing bioelectric impedance analysis in a biological model for body composition analysis; and using the results of said utilizing step to provide an objective assessment of volume and distribution of fluid and tissues, as well as electrical health of cells and membranes of said organ.
- The present invention also provides a method of organ vitality assessment, comprising the steps of: placing signal introduction electrodes on opposite lateral peripheral borders of said organ; placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement of said organ; measuring and recording first values of resistance and reactance of said organ in said initial measurement; then placing said signal introduction electrodes on said superior and said inferior borders of said organ; placing said signal detection electrodes on said opposite lateral borders of said organ; measuring and recording second values of said resistance and said reactance of said organ; and comparing said first and second values to normal values to assess vitality of said organ.
- The present invention further provides a method of organ vitality assessment for transplantation of said organ being assessed, comprising the steps of: placing signal introduction electrodes on opposite lateral peripheral borders of said organ upon harvesting of said organ; placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement upon said harvesting of said organ; measuring and recording first values of resistance and reactance of said organ in said initial measurement; then placing said signal introduction electrodes on said superior and said inferior borders of said organ; placing said signal detection electrodes on said opposite lateral borders of said organ; measuring and recording second values of said resistance and said reactance of said organ; and comparing said first and second values to normal values to determine if said organ is acceptable or not for said transplantation.
- The present invention possesses many advantages and features which will become more apparent to those persons skilled in this particular area of technology and to other persons after having read the detailed description of the present invention as set forth hereinbelow in conjunction with the accompanying patent drawings.
-
FIG. 1 is a schematic illustration of one embodiment of the present invention. -
FIG. 2 illustrates how electrodes may be placed on a hand for the BIA testing procedure. -
FIG. 3 illustrates how the electrodes may be placed on the foot for the BIA testing. - BIA is an electrodiagnostic methodology based upon the conductive properties of the body's tissues, cells, and fluids. The BIA instrument, such as that disclosed in U.S. Pat. No. 5,372,141, an impedance plethysmograph, may use a constant current source producing a low-voltage electrical signal, usually 800 micro-amps at a high frequency, often fixed at 50 KHz, to set up an electrical field in the whole body or a body segment using a pair of surface ECG-type electrodes.
- The methods of the present invention can utilize a modification of the body composition analyzer disclosed in U.S. Pat. No. 5,372,141, the entire contents of which are incorporated herein by reference thereto.
- In accordance with the present invention, utilization of BIA in a biological model for BCA provides an objective assessment of the study subject's (whole body or organ) volume and distribution of fluids and tissues, as well as the electrical health of the cells and membranes.
- The characteristics of BIA include precision, accuracy, feasibility and economy. BIA may be applied to any area of interest, regionally or to the whole body. It is non-offensive, causing no harm. It may be repeated freely, as desired, to illustrate change over time so that progression of conditions can be monitored and intervention modified.
- One aspect of the present invention applies the BIA technology for BCA assessment of vitality of organs for transplant, vitality of organs from other species for human transplantation (xenotransplantation), and to monitor and assess the timing of death.
- Organ vitality assessment is based upon the ability of a modified BIA for BCA to illustrate the health of cells by the measured reactance (X).
- Upon organ harvest, signal introduction electrodes are placed on the opposite lateral peripheral borders of the organ being assessed, and signal detection electrodes are placed at the superior and inferior borders of the organ being assessed for the first part of the initial The values of electrical resistance (R) and impedance (X) are measured and recorded.
- The signal introduction electrodes are then re-positioned or placed on the superior and inferior borders of the organ being assessed, while the signal detection electrodes are now re-positioned or placed the opposite lateral peripheral borders of the organ being assessed.
- Further values of R and X are measured and recorded.
- The values are then compared to normal values, and the organ is determined to be acceptable or not.
- If acceptable, prior to organ implant (transplantation or xenotransplantation), the sequence of steps described hereinabove is repeated with comparison being made to the electrical values which were measured and recorded upon organ harvest.
- The values should be within an acceptable range of agreement denoting no further loss of organ vitality, and then the implantation is completed.
- In accordance with the present invention, the same scenario is utilized for organs from different species.
- For determination of the timing of death, whole body measurements are made at predetermined intervals of time (preferably, but not necessarily, every other day) with electrical resistance (R), reactance (X), and phase angle (f) being measured and recorded. Initial values are compared to normal values and to those serially measured and recorded.
- The uncorrectable loss of cell mass and membrane capacity, as evidenced by a reduction in X and f or by an uncorrectable and increasing disparity of ECW (extracellular water) volume being greater than ICW (intracellular water) volume and remaining uncorrectable, are the hallmarks of the progression to the death of the biological entity.
-
- f values less than four degrees denote serious illness.
- f values less than two degrees denote imminent demise.
- One embodiment of the present invention provides a method for determining illness of a biological entity, progression to death of said biological entity, and/or timing of death of said biological entity, comprising the steps of: taking whole body measurements of resistance, reactance, phase angle, extracellular water volume, and intracellular water volume at predetermined intervals of time; recording said whole body measurements; comparing initial values of said whole body measurements to normal values of said whole body measurements and to serially measured values of said whole body measurements; and determining from said comparison step hallmarks of said illness of said biological entity, said progression to said death of said biological entity, and/or said death of said biological entity.
- Another embodiment of the present invention provides a method of organ vitality assessment for transplantation of said organ being assessed, comprising the steps of: placing signal introduction electrodes on opposite lateral peripheral borders of said organ upon harvesting of said organ; placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement upon said harvesting of said organ; measuring and recording first values of resistance and reactance of said organ in said initial measurement; then placing said signal introduction electrodes on said superior and said inferior borders of said organ; placing said signal detection electrodes on said opposite lateral borders of said organ; measuring and recording second values of said resistance and said reactance of said organ; and comparing said first and second values to normal values to determine if said organ is acceptable or not for said transplantation.
- There will now be described a preferred embodiment of the present invention. The preferred embodiment provides a method and apparatus for use in detecting the presence and severity of illness, the effectiveness of treatment interventions, and the ability to change treatment to be more effective or aggressive; to optimize outcome, limit morbidity and mortality and illustrate the patient's prognosis.
- The purpose of the preferred embodiment is to empower the healthcare provider and the patient by detecting and characterizing the presence and nature of illness and injury to include episodic, serious, and non-episodic illness and injury, its progression, and the effectiveness of treatment interventions and the prognosis of the patient.
- There is provided a method and system for use in detecting the presence and severity of illness in diagnosing and treating a patient to optimize the treatment intervention and determine the prognosis of the patient.
- This system employs the use of Whole Body Impedance Analysis to measure the patient's Resistance, Reactance, Phase Angle, and related electrical values at a healthy baseline, and thereafter in relation to the patient's complaints to evaluate the temporal or progressive nature of negative values or diminution of the measured values over time.
- Specifically, the system identifies the patient's healthy baseline measured electrical values and, during routine health examinations or when the patient complains of any symptoms or experiences any signs of illness or injury, illustrates excursion from the baseline values that may exceed a thirty-day time frame or progressively diminish. Episodic illness and recoverable injury is characterized by a brief, less than thirty days, excursion below the baseline values and return to the baseline values. More severe illness and injury are characterized by progressive or rapid diminution of the measured values.
- Once an effective treatment intervention is begun, the measured values will stabilize and then return to the baseline values indicative of the patient's positive prognosis. More effective treatment is indicated by a more rapid return to baseline-measured values. If the values do not improve, a modified or more aggressive treatment intervention is indicated whose positive effectiveness will be indicated by the initial stabilization of the measured values and their subsequent return to baseline values. Prognosis is proportional to the speed and direction of the return of the measured value to or from the baseline values. A positive prognosis is indicated by a progressive and/or rapid return to the measure baseline values. A negative prognosis is indicated by a progressive and/or rapid diminution of the measured values. The speed of loss or gain of the measured values is proportional to the return of health or the severity of the illness or injury. A neutral or stabilized measured value lower than the healthy baseline, over an extended period of time, greater than six months, indicates a new baseline, a less healthy condition and pre-disposition to future illness.
- Frequency of measurements is in proportion to the severity of the process to be illustrated; more severe illness or injury, characterized by more severe symptoms, signs and negative laboratory findings and progressive and/or rapid diminution of the measured values, require more frequent measurements, daily and every other day. Less severe illnesses and injuries may be illustrated with weekly measurements.
- The invention will now be further explained with reference to
FIGS. 1-3 . - The primary study method for an impedance plethsymographic examination either Whole-Body 1 or Regional 2 is simple and straightforward. The patient requires no advanced preparation for the study. However, the patient should not be diaphoretic, soaked in urine or any other surface liquid that would provide an alternative pathway for the conduction of the electrical signal that is the basis of the study.
- The patient is counseled to lie quietly, motionless, and informed that the test will take less than five minutes if the patent is cooperative. The patient is generally placed in a supine position with arms and legs abducted about thirty degrees from the midline on a dry non-conductive surface. Whole Body 1 and Regional 2 studies require a tetrapolar electrode scheme in which placement of four (two pairs) surface, ECG electrodes in strict relation to anatomical landmarks at the wrist and ankle. If the patient's skin is either too dry or too oily, wiping the electrode placement area with an alcohol prep wipe is suggested. The right side of the body is generally used with the electrodes placed ipsilaterally. However if the patient's condition requires contra-lateral placement and alternative body positions, they can be utilized with the understanding and proviso that the same position will be repeated with all future measurements. The signal detection (SD) electrodes 3 or 4 must be placed with the greatest precision in relation to known anatomical landmarks on both the wrist and the ankle.
- On the wrist, the superior linear border of the electrode, its top straight line, must equally bisect the ulnar stylus, bone prominence (bump) on the little finger side of the wrist with the tab of the electrode facing away from the body of the patient. The signal introduction (SI)
electrodes 5 are placed distal from the SD electrodes 3 and must be kept at a minimum distance that equals or exceeds that of the diameter of the segment being measured (e.g., the wrist). This is most easily and efficiently accomplished by using the distal phalanx of the middle finger, just proximal to the nail. - On the ankle, the SD electrode 4 is placed so that the superior linear border equally bisects the medial malleolous (the bump on the big toe side of the ankle) with the tab facing outwards from the patient. Care should be exercised to use the medical malleolous because the lateral malleolous (the bump on the little toe side of the ankle) is inferior or below the medial malleolous landmark. The SI electrode 6 is placed on the big toe, as shown in
FIG. 1 . - The plethysmograph is connected via patient cable leads with strict attention paid to SI and SD leads connected to SI and SD electrodes. The device is energized and the values of resistance and reactance in ohms, are measured individually, allowing a moment (ten to fifteen seconds) to settle, and then are recorded. The electrodes are carefully removed so as not to injure friable skin or contaminate the examiner.
- Any standard impedance plethysmograph that utilizes a 500-800 micro-amp constant current electrical source at 50-kilohertz frequency can be utilized. Preferably, but not necessarily, an RJL Systems, Inc. manufactured Quantum II instrument system may be used for both Whole Body 1 and Regional 2 measurements.
- For Regional 2 measurements, the patient is prepared in the same manner as with a Whole-Body 1 examination. For Regional 2 measurements of the chest, abdomen or extremities (arms/legs, left-right, upper or lower), the
signal detection electrodes 7 are placed superiorly and inferiorly in precise relation to the area of interest. The distance between the detection electrodes is precisely measured and recorded in centimeters. The skin is marked with a surgical pen to assure accurate and reproducible electrode placement for serial measurements. The SI electrodes 1 are best placed in the standard Whole-Body locations, however this requires a specialized patient cable with adequate distance or throw, about eighteen inches of length allowed, between the insertion point into the patient cable to and from the clip ends. The impedance plethysmograph is connected via the patient cables with strict adherence to the SD lead to the SD electrode and the SI lead to the SI electrode. The measured values are recorded and the electrodes carefully removed. - The measured values, resistance, reactance and phase angle are recorded, archived and graphically presented to illustrate change over time and illuminate the processes of disease progression and response to treatment. The frequency of serial measurements is proportional to the dynamic of the event to be captured. If at all possible, a baseline study value is particularly desirable.
- Disorders characterized by dynamic shifts of extracellular fluid volumes require more frequent measurements, often prior to and after a procedure or treatment such as a patient requiring hemodialysis, aggressive diuresis in organ failure or repletion of fluids in acute dehydration or trauma. The measured resistance value in ohms is inversely proportional to the extracellular fluid volume of the patient. When resistance ohms decrease fluid has increased and conversely when resistance ohms increase fluid volume has decreased. So, once an initial ohm measurement value is established by baseline or first study, subsequent measurements illustrate the patient's course and response to disease progression and the effectiveness of the selected treatment intervention. The severity of the disease or insult condition evidenced by the speed of the excursion from baseline or initial measurement value. Fluid changes that move more than fifty ohms in a twenty-four hour period are severe and indicate a more acute and serious condition than those that move fifty ohms in a week's time indicative of a more chronic condition. Both conditions require intervention, however as chronic insidious changes are as adverse to survival as more rapid changes.
- These changes may be evidenced in both Whole Body 1 and Regional 2 measurements. Whole Body 1 measurements are more general in their value, indicative of conditions and events that encompass the organism as a whole such as cardiac or renal failure and acute dehydration. Regional 2 measurements provide a site-specific assessment of fluid volumes such as those found with pleural effusion in the chest, ascites in the abdomen or even cerebral edema. The changes of measured electrical values precede changes seen on x-ray, physical examination, or from laboratory studies.
- Once again, increasing ohms of resistance indicate a drying and fluid reduction while decreasing ohms of resistance indicate increased fluid volumes. Thoracic resistance values that are increasing indicate a drying chest and conversely decreasing resistance values indicate additional accumulation of fluid. These changes clearly indicate the improvement or worsening of disease conditions and the individual's response to treatment and ergo, its effectiveness. The extent and aggressiveness of therapy can be altered and modified to “optimize” the beneficial effects.
- Reactance values are proportional to the number and integrity (health) of cell wall membranes so when cells increase or decrease reactance values follow. The cells that change in this manner are those of the somatic and visceral protein tissues, such as skeletal musculature organs such as the liver, spleen, lungs, heart stomach and intestines. Cellular alterations are generally slower to occur and are affected by metabolic and specific disease processes. However, overly aggressive diuresis, excessive hemodialysis or cellular targeted pathologies such as Rhabdomyolysis can all result in rapid, days versus a week, changes in cell mass, membrane status and measured reactance values. Excursions from the baseline or initial measurement value indicate the type and progression of disease and/or the effectiveness of treatment interventions. Increased cells (membranes) and anabolic metabolism are evidenced by a rise in the ohms of reactance, generally a sign of improvement. A slowly decreasing ohm value of reactance indicates a negative or catabolic metabolism condition. A more precipitous and rapid decrease in reactance is indicative of unique conditions that rapidly affect cells and their membranes, such as the effect of Rhabdomyolysis skeletal muscle or rejection or infection of an organ system.
- Regional measurement values of ohms of reactance are used for these disease specific investigations while whole body values are used for the assessment of metabolic evaluation.
- A derivative of the measured values of resistance and reactance is the arc tangent of reactance to resistance expressed in degrees or Phase Angle. Phase Angle is the cumulative expression of the changes and ratios of cell mass and extracellular fluid that result from disease, insult and/or treatment intervention and can by itself be used to gauge the severity and progression of pathologies and the effectiveness and benefits of treatment. A positive prognosis is indicated by an increasing phase angle while a poor prognosis is associated with a phase angle decrease. Phase angle has been correlated with survival and the timing of non-acute death. Phase angle can be derived from both whole body and regional measurements and followed serially to establish prognosis.
- Treatment interventions can be measured for their effectiveness on the individual patient by following phase angle. More effective treatments are evidenced by an increasing phase angle while those less effective are seen as producing little or no increase. Once phase angle degrades to below four degrees, the patient is seriously ill and treatment should be aggressive and modified to be effective and optimal. If phase angle does not stabilize or increase through multiple iterations of treatment, a curative or restorative treatment goal outcome is doubtful. A phase angle of less than two degrees is associated with pending mortality and a need for palliative care and comfort. Admission to a hospice can be objectively based upon phase angle monitoring providing the patient with improved end-of-life care and comfort.
-
FIG. 2 illustrates how electrodes may be placed on the hand for the BIA Testing Procedure. - The detecting electrode edge 8 is placed on an imaginary line bisecting the ulna head (bone on little finger side of wrist).
- The signal electrode 9 is placed on the first joint of the middle finger.
-
FIG. 3 illustrates how electrodes may be placed on the foot. - The detecting electrode edge 10 is placed on an imaginary line bisecting the medial mellealus (bone on big toe side of ankle).
- The signal electrode 11 is placed on the base of the second toe.
- The exam area should be comfortable and free of drafts and portable electric heaters. The exam table surface must be non-conductive and large enough for the subject to line supine with the arms 30 degrees from the body, and legs not in contact with each other.
- The subject should not have exercised or taken a sauna within 18 hours of the study. The subject should refrain from alcohol intake for 12 hours prior to the study. The subject's height and weight should be accurately measured and recorded. The subject should lie quietly during the entire test. The subject should not be wet from sweat or urine.
- The subject should not have a fever or be in shock. The study and testing procedure should be explained to the subject.
- The subject should remove the shoe and sock and any jewelry on the electrode side (generally the study is completed on the right side of the body). The body side (left or right) should always be used subsequently.
- The subject should lie supine with the arms 30 degrees from the body with legs not touching.
- The electrode sites may be cleaned with alcohol, particularly if the skin is dry or covered with lotion.
- The electrodes and patient cables are attached as shown in
FIGS. 2 and 3 . - The analyzer is turned on, making sure the subject refrains from moving. When the measurements have stabilized, record the displayed Resistance (R) and Reactance (Xc) with the subject's name, age, gender, height and weight.
- The entire testing time is less than 5 minutes—the BIA analyzer is on for less than one minute.
- The results are available immediately from the software program.
- The study may be repeated as often as necessary.
- The present invention also embraces the features of using the invention for various areas of interest, for example, whole-body thoracic, abdominal, extremity, etc.
- Although the invention has been described in detail in the foregoing only for the purpose of illustration, it is to be understood that such detail is solely for that purpose and that variations and modifications can be made therein by those of ordinary skill in the art without departing from the spirit and scope of the invention including all equivalents thereof.
Claims (20)
1. A method of organ vitality assessment, comprising the steps of:
utilizing bioelectric impedance analysis in a biological model for body composition analysis; and
using the results of said utilizing step to provide an objective assessment of volume and distribution of fluid and tissues, as well as electrical health of cells and membranes of said organ.
2. The method according to claim 1 , including the step of:
utilizing a modified bioelectric impedance analysis for body composition analysis to assess the health of cells of said organ by the measured reactance thereof.
3. A method according to claim 1 , including the steps of:
placing signal introduction electrodes on opposite lateral peripheral borders of said organ;
placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement of said organ;
measuring and recording first values of resistance and reactance, and calculating the phase angle of said organ in said initial measurement;
then placing said signal introduction electrodes on said superior and said inferior borders of said organ;
placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording second values of said resistance and said reactance, and calculating the phase angle of said organ; and
comparing said first and second values to normal values to assess vitality of said organ.
4. A method according to claim 2 , including the steps of:
placing signal introduction electrodes on opposite lateral peripheral borders of said organ;
placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement of said organ;
measuring and recording first values of resistance and reactance, and calculating the phase angle of said organ in said initial measurement;
then placing said signal introduction electrodes on said superior and said inferior borders of said organ;
placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording second values of said resistance and said reactance, and calculating the phase angle of said organ; and
comparing said first and second values to normal values to assess vitality of said organ.
5. A method according to claim 3 , including the following additional steps:
again placing said signal introduction electrodes on said opposite lateral peripheral borders of said organ;
again placing said signal detection electrodes at said superior and said inferior borders of said organ;
measuring and recording third values of resistance and reactance, and calculating the phase angle of said organ;
then again placing said signal introduction electrodes on said superior and said inferior borders of said organ;
again placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording fourth values of said resistance and said reactance of said organ; and
comparing said first and second values to said third and fourth values to determine if the values are within a predetermined acceptable range of agreement denoting no further loss of said organ vitality.
6. A method according to claim 4 , including the following additional steps:
again placing said signal introduction electrodes on said opposite lateral peripheral borders of said organ;
again placing said signal detection electrodes at said superior and said inferior borders of said organ;
measuring and recording third values of resistance and reactance, and calculating the phase angle of said organ;
then again placing said signal introduction electrodes on said superior and said inferior borders of said organ;
again placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording fourth values of said resistance and said reactance, and calculating the phase angle of said organ; and
comparing said first and second values to said third and fourth values to determine if the values are within a predetermined acceptable range of agreement denoting no further loss of said organ vitality.
7. A method according to claim 1 , including the steps of:
upon harvesting said organ from a donor, placing signal introduction electrodes on opposite lateral peripheral borders of said organ;
placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement of said organ;
measuring and recording first values of resistance and reactance, and calculating the phase angle of said organ in said initial measurement;
then placing said signal introduction electrodes on said superior and said inferior borders of said organ;
placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording second values of said resistance and said reactance, and calculating the phase angle of said organ; and
comparing said first and second values to normal values to assess vitality of said organ.
8. A method according to claim 2 , including the steps of:
upon harvesting said organ from a donor, placing signal introduction electrodes on opposite lateral peripheral borders of said organ;
placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement of said organ;
measuring and recording first values of resistance and reactance, and calculating the phase angle of said organ in said initial measurement;
then placing said signal introduction electrodes on said superior and said inferior borders of said organ;
placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording second values of said resistance and said reactance, and calculating the phase angle of said organ; and
comparing said first and second values to normal values to assess vitality of said organ.
9. A method according to claim 7 , including the steps of:
upon arrival of said organ at the location of a recipient, placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement of said organ;
measuring and recording first values of resistance and reactance, and calculating the phase angle of said organ in said initial measurement;
then placing said signal introduction electrodes on said superior and said inferior borders of said organ;
placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording second values of said resistance and said reactance, and calculating the phase angle of said organ; and
comparing said first and second values to normal values to assess vitality of said organ.
10. A method according to claim 8 , including the steps of:
upon arrival of said organ at the location of a recipient, placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement of said organ;
measuring and recording first values of resistance and reactance, and calculating the phase angle of said organ in said initial measurement;
then placing said signal introduction electrodes on said superior and said inferior borders of said organ;
placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording second values of said resistance and said reactance, and calculating the phase angle of said organ; and
comparing said first and second values to normal values to assess vitality of said organ.
11. A method according to claim 9 , including the steps of:
prior to the implantation of said organ into said recipient, again placing said signal detection electrodes at said superior and said inferior borders of said organ;
measuring and recording third values of resistance and reactance, and calculating the phase angle of said organ;
then again placing said signal introduction electrodes on said superior and said inferior borders of said organ;
again placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording fourth values of said resistance and said reactance of said organ; and
comparing said first and second values to said third and fourth values to determine if the values are within a predetermined acceptable range of agreement denoting no further loss of said organ vitality.
12. A method according to claim 10 , including the steps of:
prior to the implantation of said organ into said recipient, again placing said signal detection electrodes at said superior and said inferior borders of said organ;
measuring and recording third values of resistance and reactance, and calculating the phase angle of said organ;
then again placing said signal introduction electrodes on said superior and said inferior borders of said organ;
again placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording fourth values of said resistance and said reactance of said organ; and
comparing said first and second values to said third and fourth values to determine if the values are within a predetermined acceptable range of agreement denoting no further loss of said organ vitality.
13. A method of organ vitality assessment, comprising the steps of:
placing signal introduction electrodes on opposite lateral peripheral borders of said organ;
placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement of said organ;
measuring and recording first values of resistance and reactance of said organ in said initial measurement;
then placing said signal introduction electrodes on said superior and said inferior borders of said organ;
placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording second values of said resistance and said reactance of said organ; and
comparing said first and second values to normal values to assess vitality of said organ.
14. A method according to claim 13 , including the following additional steps:
again placing said signal introduction electrodes on said opposite lateral peripheral borders of said organ;
again placing said signal detection electrodes at said superior and said inferior borders of said organ;
measuring and recording third values of resistance and reactance, and calculating the phase angle of said organ;
then again placing said signal introduction electrodes on said superior and said inferior borders of said organ;
again placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording fourth values of said resistance and said reactance, and calculating the phase angle of said organ; and
comparing said first and second values to said third and fourth values to determine if the values are within a predetermined acceptable range of agreement denoting no further loss of said organ vitality.
15. A method of organ vitality assessment for transplantation of an organ being assessed, comprising the steps of:
placing signal introduction electrodes on opposite lateral peripheral borders of said organ upon harvesting of said organ;
placing signal detection electrodes at superior and inferior borders of said organ for a first part of an initial measurement upon said harvesting of said organ;
measuring and recording first values of resistance and reactance of said organ in said initial measurement;
then placing said signal introduction electrodes on said superior and said inferior borders of said organ;
placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording second values of said resistance and said reactance of said organ; and
comparing said first and second values to normal values to determine if said organ is acceptable or not for said transplantation.
16. A method according to claim 15 , wherein:
if said organ is acceptable, then prior to implanting said organ, performing the following steps;
again placing said signal introduction electrodes on said opposite lateral peripheral borders of said organ;
again placing said signal detection electrodes at said superior and said inferior borders of said organ for a first part of an initial post-harvest/pre-implant measurement;
measuring and recording third values of resistance and reactance of said organ in said initial post-harvest/pre-implant measurement;
then placing said signal introduction electrodes on said superior and said inferior borders of said organ;
placing said signal detection electrodes on said opposite lateral borders of said organ;
measuring and recording fourth values of said resistance and said reactance of said organ; and
comparing said first and second values to said third and fourth values to determine if the values are within a predetermined acceptable range of agreement denoting no further loss of said organ vitality.
17. A method according to claim 15 , wherein:
once said organ is transplanted into a recipient, follow-up measurements of whole-body and regional resistance and reactance and the calculation of phase angle specific to a site of transplant of said organs, will be made with electrodes placed for a whole-body measurement (wrist and ankle) and with the detection electrodes superior and inferior, as well as medial lateral to the organ site.
18. A method according to claim 16 , wherein:
once said organ is transplanted into a recipient, follow-up measurements of whole-body and regional resistance and reactance and the calculation of phase angle specific to a site of transplant of said organs, will be made with electrodes placed for a whole-body measurement (wrist and ankle) and with the detection electrodes superior and inferior, as well as medial lateral to the organ site.
19. A method according to claim 15 , including:
harvesting said organ from a first species of biological entity; and
implanting said organ in a different species of biological entity.
20. A method according to claim 16 , including:
harvesting said organ from a first species of biological entity; and
implanting said organ in a different species of biological entity.
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Also Published As
Publication number | Publication date |
---|---|
US7136697B2 (en) | 2006-11-14 |
US20050209527A1 (en) | 2005-09-22 |
US20040092841A1 (en) | 2004-05-13 |
US7003346B2 (en) | 2006-02-21 |
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