US20050187625A1 - Vertebral body replacement apparatus and method - Google Patents
Vertebral body replacement apparatus and method Download PDFInfo
- Publication number
- US20050187625A1 US20050187625A1 US11/031,362 US3136205A US2005187625A1 US 20050187625 A1 US20050187625 A1 US 20050187625A1 US 3136205 A US3136205 A US 3136205A US 2005187625 A1 US2005187625 A1 US 2005187625A1
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0041—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using additional screws, bolts, dowels or rivets, e.g. connecting screws
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/006—Additional features; Implant or prostheses properties not otherwise provided for modular
- A61F2250/0063—Nested prosthetic parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0082—Additional features; Implant or prostheses properties not otherwise provided for specially designed for children, e.g. having means for adjusting to their growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
Definitions
- Various embodiments of the present invention relate to an apparatus for vertebral body replacement and methods associated therewith.
- a vertebral body replacement apparatus may be used to correct and stabilize the spine (e.g., the thoracolumbar spine (T1-L5)).
- the spine e.g., the thoracolumbar spine (T1-L5).
- a vertebral body e.g., a diseased and/or damaged vertebral body
- a vertebral body that has been resected or excised (e.g., for the treatment of a tumor or trauma) may be replaced (with the height of the resected or excised vertebral body being substantially replaced and restored by the apparatus of the present invention).
- Examples of various patent documents in the spinal implant area include the following:
- U.S. Pat. No. 5,192,327 to Brantigan relates to a surgical prosthetic implant for vertebrae. More particularly, surgical prosthetic modular implants used singularly or stacked together are provided to support and fuse together adjacent vertebrae or to totally or partially replace one or more vertebrae in a vertebral column.
- the implants are rigid annular plugs, dimensionally similar to normal vertebral bodies, have simplified oval or hemi-oval shapes with ridged faces to engage adjacent vertebral bodies to resist displacement and allow bone ingrowth and fusion and to interdigitate with the ridges of an adjacent plug for modular stacking to allow variability of ultimate implant height.
- the implants can be provided in sets of different thicknesses and are internally grooved to receive an upstanding connecting bar to bind together the individual stacked implants into a stable unit.
- the annular implants have ample spaces to allow ingrowth of blood capillaries and packing of bone graft and are preferably made of a radiolucent material, preferably biocompatible carbon fiber reinforced polymers or are alternately made of traditional orthopaedic implant materials such as nickel, chromium, cobalt, stainless steel or titanium.
- an interbody fusion device includes a pair of lateral spacers and a pair of central spacers, each sized for percutaneous introduction through a disc resection portal in the disc annulus.
- Each of the lateral spacers includes opposing side faces defining a channel therein, while each of the central spacers includes arms at their opposite ends configured to be received within a channel of a corresponding lateral spacer.
- the arms and channels are interlocking to prevent separation of the components once assembled within the intradiscal space.
- the assembly of the central and lateral spacers defines a cavity therebetween for insertion of bone graft material.
- the central and lateral spacers are configured so that the bone graft cavity is oriented over the weakest, but most vascular and biologically active, bone of the vertebral body, while the lateral spacers are situated adjacent the disc annulus and over the strongest vertebral bone.
- U.S. Pat. No. 6,159,211 to Boriani et al. relates to a stackable cage system for corpectomy/vertebrectomy. More particularly, surgical prosthetic modular devices used singularly or stacked together are provided for use to replace excised vertebral tissue.
- the devices are rigid plugs, dimensionally similar to normal vertebral bodies, and have ridged faces to engage adjacent vertebral bodies or to interdigitate when stacked. Ridges extend in both the medial/lateral and anterior/posterior directions to prevent slipping in the anterior/posterior and medial/lateral directions respectively.
- a locking screw may be used to secure a stack to form a singular rigid prosthetic device.
- the devices are also provided with a plurality of threaded openings.
- a device is used to replace excised vertebral tissue, threaded bolts are inserted into the threaded openings, and other spine stabilization devices are attached to the bolts.
- the device In corporectomies, the device can be bolted to a plate, which in turn is fixed to adjacent vertebrae. In spondylectomies, the device can be fixed to a series of posteriorly placed rods.
- an interbody fusion device for engagement between vertebrae includes a pair of lateral spacers for spacing the vertebrae, and a connecting member adapted to couple together the lateral spacers when inserted between the vertebrae.
- the connecting member, individual lateral spacers, or the entire spinal spacer can be made of bone in order to promote fusion of the vertebrae.
- the modular construction permits use of bone segments otherwise unsuitable due to size or strength in stable fusion devices.
- an interbody fusion device for engagement between vertebrae includes a pair of lateral spacers for spacing the vertebrae, and a connecting member adapted to couple together the lateral spacers when inserted between the vertebrae.
- the connecting member, individual lateral spacers, or the entire spinal spacer can be made of bone in order to promote fusion of the vertebrae.
- the modular construction permits use of bone segments otherwise unsuitable due to size or strength in stable fusion devices.
- FIG. 1 shows a perspective view of one embodiment of a vertebral body replacement implant assembly according to the present invention
- FIG. 2 shows another view of the implant assembly of FIG. 1 as it would look outside of the body
- FIGS. 3A and 3B show exploded perspective views of the implant assembly of FIGS. 1 and 2 ( FIG. 3A shows an embodiment of the implant assembly from one angle and FIG. 3B shows an embodiment of the implant assembly from another angle);
- FIG. 4 shows a perspective view of an endplate type component of an implant assembly according to an embodiment of the present invention
- FIG. 5 shows a perspective view of a non-lordotic lateral spacer type component of an implant assembly according to an embodiment of the present invention
- FIG. 6 shows a perspective view of a lordotic lateral spacer type component of an implant assembly according to an embodiment of the present invention
- FIG. 7 shows a plan view of an implant assembly according to an embodiment of the present invention.
- FIG. 8 shows section A-A of FIG. 7 ;
- FIG. 9 shows Detail B of FIG. 8 ;
- FIG. 10 shows a plan view of another embodiment of the present invention.
- FIGS. 15 and 16 show, respectively, a perspective view and an exploded perspective view of another embodiment of the present invention.
- FIGS. 17A-17G show perspective views of various components according to an embodiment of the present invention.
- FIGS. 18, 19A , 19 B, 20 A, 20 B and 21 show perspective views of various implant assemblies using the components of FIGS. 17A-17G ;
- FIGS. 22A-22E show various views of an implant assembly using the components of FIGS. 17A-17G ;
- FIG. 23 shows a perspective view of another embodiment of a vertebral body replacement implant assembly according to the present invention.
- FIG. 24 shows another view of the implant assembly of FIG. 23 as it would look outside of the body
- FIG. 25 shows an exploded perspective view of the implant assembly of FIGS. 23 and 24 ;
- FIG. 26 shows a perspective view of an endplate type component of an implant assembly according to an embodiment of the present invention
- FIG. 27 shows a perspective view of a non-lordotic lateral spacer type component of an implant assembly according to an embodiment of the present invention
- FIG. 28 shows a perspective view of a lordotic lateral spacer type component of an implant assembly according to an embodiment of the present invention
- FIG. 29 shows a plan view of an implant assembly according to an embodiment of the present invention.
- Implant Assembly 101 may be implanted between First Vertebra 103 a and Second Vertebra 103 b ( FIG. 2 shows another view of Implant Assembly 101 as it would look outside of the body).
- Implant Assembly 101 may be formed of a number of components fitted together.
- Implant Assembly 101 may be formed of, for example, four components: (a) First Endplate 301 (e.g., a top Endplate), Second Endplate 303 (e.g., a bottom Endplate), First Lateral Spacer 305 and Second Lateral Spacer 307 .
- First Endplate 301 may include: First Offset Aperture 301 a (e.g., offset relative to a centerline of Endplate 301 ); Second Offset Aperture 301 b (e.g., offset relative to a centerline of Endplate 301 ); Protrusions 301 c and 301 d (these Protrusions are seen most clearly in FIG.
- Second Endplate 303 may include: First Offset Aperture 303 a (e.g., offset relative to a centerline of Endplate 303 ); Second Offset Aperture 303 b (e.g., offset relative to a centerline of Endplate 303 ); Protrusions 303 c - 303 f ; Insertion Tool Mating Aperture 303 g (for mating with an insertion tool (not shown)); and various grooves disposed along the bottom surface (the grooves are not separately numbered in the Figs.).
- First Lateral Spacer 305 may include: Main Aperture 305 a (which may at least partially line-up with First Offset Aperture 301 a and First Offset Aperture 303 a ; various Auxiliary Apertures (not separately numbered in the Figs.); and various grooves disposed along the top surface and the bottom surface (the grooves are not separately numbered in the Figs.).
- Second Lateral Spacer 307 may include: Main Aperture 307 a (which may at least partially line-up with Second Offset Aperture 301 b and Second Offset Aperture 303 b ; various Auxiliary Apertures (not separately numbered in the Figs.); and various grooves disposed along the top surface and the bottom surface (the grooves are not separately numbered in the Figs.).
- FIGS. 3A and 3B are similar, with the main differences being the shape of the internal centerline bosses on the inner faces of the First Endplate and Second Endplate and the fact that the Protrusions in the embodiment of FIG. 3A are essentially featureless (such that they provide lateral alignment/support) while the Protrusions of the embodiment of FIG. 3B provide locking features such as the ridges shown in the Fig. but not separately numbered (such that the ridges cooperate with mating indentations (shown in the Fig. but not separately numbered) in the First Lateral Spacer and the Second Lateral Spacer to provide both lateral alignment/support as well as up-down locking (e.g., removable locking) of the components).
- a tab and slot system may be utilized for locking.
- Implant Assembly 101 may provide for bony ingrowth and/or may be packed with bone matter. This may be accomplished via the hollow fenestrated design of the components (e.g., via First Offset Aperture 301 a ; Second Offset Aperture 301 b ; First Offset Aperture 303 a ; Second Offset Aperture 303 b ; Main Aperture 305 a ; Main Aperture 307 a ; and/or the various Auxiliary Apertures) and/or the hollow fenestrated design of the finished implant assembly (e.g., via the space(s) between First Lateral Spacer 305 and Second Lateral Spacer 307 at each end of the finished implant assembly).
- the hollow fenestrated design of the components e.g., via First Offset Aperture 301 a ; Second Offset Aperture 301 b ; First Offset Aperture 303 a ; Second Offset Aperture 303 b ; Main Aperture 305 a
- Implant Assembly 101 may be provided in two footprint sizes.
- the “small” footprint may measure, for example, 28 mm wide ⁇ 23 mm length (in this example each “small” footprint size Endplate may be 28 mm wide ⁇ 23 mm length, and each Lateral Spacer may be 8 mm wide ⁇ 23 mm length).
- the “large” footprint may measure, for example, 35 mm wide ⁇ 28 mm length (in this example each “large” footprint size Endplate may be 35 mm wide ⁇ 28 mm length, and each Lateral Spacer may be 8 mm wide ⁇ 28 mm length).
- One or both footprint sizes may be available in height ranges from, for example, 12 mm to 60 mm (in increments of one millimeter, for example).
- Tables 4-6 identify example thicknesses of the components of a “small” implant assembly (of course, these examples are intended to be illustrative and not restrictive). More particularly, Table 4 identifies example thicknesses of a “small” End Plate (see, e.g., FIG. 4 for a perspective view of this type of component), Table 5 identifies example thicknesses of a “small” Non-Lordotic Lateral Spacer (see, e.g., FIG. 5 for a perspective view of this type of component) and Table 6 identifies example thicknesses of a “small” Lordotic Lateral Spacer (see, e.g., FIG. 6 for a perspective view of this type of component). TABLE 4 (All measurements in mm) 2 3 4
- Such snapping construction may be carried out, for example, using a lip and undercut arrangement (see FIG. 7 (showing a plan view of an implant assembly according to an embodiment of the present invention), FIG. 8 (showing section A-A of FIG. 7 ), and FIG. 9 (showing Detail B of FIG. 8 )). More particularly, with regard to such snapping construction, attention is directed to the features of FIG. 9 which show the undercut in the lateral spacer and the tapered lip on the endplate (wherein an interference may exist in the assembly until the tapered lip reaches the undercut and snaps into place creating a lock).
- some or all of the components may include or be made essentially entirely from polyetheretherketone (e.g., PEEK Optima).
- PEEK Optima polyetheretherketone
- this PEEK polymer material has radiolucent properties, which may aid the surgeon in determining if fusion (e.g., in the operative site) has occurred. Since such PEEK material is essentially transparent to x-rays, markers (e.g., markers made of titanium) may be inserted into one or more of the components to give a surgeon a visual aid in determining the location of the component and/or entire implant assembly (e.g., both inter and postoperatively).
- Indications relating to use of the present invention may include (but not be limited to):
- one or more of the components and/or the implant assembly may have a tapered lead-in (e.g., for easy insertion).
- each lateral spacer may be capable of supporting the vertebral column.
- the textured surface of the components and/or the implant assembly may allow for easy insertion and/or resistance to expulsion (see FIGS. 10-14 for additional textured surface examples (which examples are intended to be illustrative and not restrictive)).
- multiple lateral spacer type components may be assembled in a “bridge” configuration (see FIGS. 15 and 16 , for example).
- the components may be assembled as desired (see FIGS. 17A-17G , 18 , 19 A, 19 B, 20 A, 20 B, 21 and 22 A- 22 E, for example).
- Implant Assembly 2301 may be implanted between First Vertebra 2303 a and Second Vertebra 2303 b ( FIG. 24 shows another view of Implant Assembly 2301 as it would look outside of the body).
- Implant Assembly 2301 may be formed of a number of components fitted together.
- Implant Assembly 2301 may be formed of, for example, four components: (a) First Endplate 2501 (e.g., a top Endplate), Second Endplate 2503 (e.g., a bottom Endplate), First Lateral Spacer 2505 and Second Lateral Spacer 2507 .
- First Endplate 2501 may include: First Offset Aperture 2501 a (e.g., offset relative to a centerline of Endplate 2501 ); Second Offset Aperture 2501 b (e.g., offset relative to a centerline of Endplate 2501 ); Protrusions 2501 c and 2501 d (these Protrusions are not seen in this Fig.
- Protrusions of Second Endplate 2503 discussed below—although in this embodiment there are four such Protrusions (two adjacent First Offset Aperture 2501 a and two adjacent Second Offset Aperture 2501 b ) any number of protrusions may be utilized); Insertion Tool Mating Aperture 2501 e (for mating with an insertion tool (not shown)); and various grooves disposed along the top surface (the grooves are not separately numbered in the Figs.).
- Second Endplate 2503 may include: First Offset Aperture 2503 a (e.g., offset relative to a centerline of Endplate 2503 ); Second Offset Aperture 2503 b (e.g., offset relative to a centerline of Endplate 2503 ); Protrusions 2503 c - 2503 f ; Insertion Tool Mating Aperture 2503 g (for mating with an insertion tool (not shown)); and various grooves disposed along the bottom surface (the grooves are not separately numbered in the Figs.).
- First Lateral Spacer 2505 may include: Main Aperture 2505 a (which may at least partially line-up with First Offset Aperture 2501 b and First Offset Aperture 2503 b ; various Auxiliary Apertures (not separately numbered in the Figs.); and various grooves disposed along the top surface and the bottom surface (the grooves are not separately numbered in the Figs.).
- Second Lateral Spacer 2507 may include: Main Aperture 2507 a (which may at least partially line-up with Second Offset Aperture 2501 a and Second Offset Aperture 2503 a ; various Auxiliary Apertures (not separately numbered in the Figs.); and various grooves disposed along the top surface and the bottom surface (the grooves are not separately numbered in the Figs.).
- FIGS. 25 and 3 A/ 3 B are similar, with the main differences being that in the embodiment of FIG. 25 each of First Endplate 2501 and Second Endplate 2503 includes pockets into which each of First Lateral Spacer 2505 and Second Lateral Spacer 2507 fits (Pockets 2503 h and 2503 i are individually identified in FIG. 25 in connection with Second Endplate 2503 —First Endplate 2501 has similar pockets which are not seen in this view).
- Implant Assembly 2301 may provide for bony ingrowth and/or may be packed with bone matter. This may be accomplished via the hollow fenestrated design of the components (e.g., via First Offset Aperture 2501 a ; Second Offset Aperture 2501 b ; First Offset Aperture 2503 a ; Second Offset Aperture 2503 b ; Main Aperture 2505 a ; Main Aperture 2507 a ; and/or the various Auxiliary Apertures) and/or the hollow fenestrated design of the finished implant assembly (e.g., via the space(s) between First Lateral Spacer 2505 and Second Lateral Spacer 2507 at each end of the finished implant assembly).
- the hollow fenestrated design of the finished implant assembly e.g., via the space(s) between First Lateral Spacer 2505 and Second Lateral Spacer 2507 at each end of the finished implant assembly.
- FIGS. 26-28 show, respectively, a perspective view of an endplate according to an embodiment of the present invention, a perspective view of a non-lordotic lateral spacer according to an embodiment of the present invention and a perspective view of a lordotic lateral spacer according to an embodiment of the present invention.
- the lateral spacers may be snapped onto a first endplate and then a second endplate may be snapped onto the two lateral spacers.
- Such snapping construction may be carried out, for example, using a lip and undercut arrangement (see FIG. 29 (showing a plan view of an implant assembly according to an embodiment of the present invention), FIG. 30 (showing section B-B of FIG. 29 ), and FIG. 31 (showing Detail C of FIG. 30 )). More particularly, with regard to such snapping construction, attention is directed to the features of FIG. 31 which show the undercut in the lateral spacer and the tapered lip on the endplate (wherein an interference may exist in the assembly until the tapered lip reaches the undercut and snaps into place creating a lock).
- an implant assembly according to the present invention may be tested in accordance with ASTM F 2077-03 “Test Methods For Intervertebral Body Fusion Devices” (or a modified version thereof) and/or the FDA's Sep. 27, 2000 “Guidance for Spinal Systems 510 ( k )'s.
- the lordotic angle may be any desired angle (e.g., 4°-8°).
- one or more components may be used separately from an implant assembly (e.g., one or more of the lateral spacers (non-lordotic and/or lordotic) may be implanted directly into the spine without use of a top and/or bottom endplate).
- the various components may take different shapes as desired and the various features may take on various specifics as desired (e.g., the various apertures may be of any desired number and/or shape).
- the apparatus (and/or its components) may, of course, have any desired dimensions (e.g., for any desired patient—man, woman or child).
- the apparatus (and/or its components) may be provided in a “line” or “family” of devices (e.g., small, medium and large; adult, child; male, female). Further still, the apparatus (and/or its components) may be provided in standard sizes. Further still, any desired locking mechanism(s) may be used to hold the various components together and/or in desired alignment. Further still, such locking may be capable of being unlocked (e.g., a mechanism and/or tool may be provided for unlocking the various components). Further still, lateral spacers(s) may be disposed adjacent one or more central spacers. Further still, any steps relating to manufacture and/or use may be performed in any desired order.
- a “line” or “family” of devices e.g., small, medium and large; adult, child; male, female.
- the apparatus (and/or its components) may be provided in standard sizes.
- any desired locking mechanism(s) may be used to hold the various components together and/or in desired alignment. Further still, such locking may be capable of
Abstract
Description
- This application is a continuation in part of U.S. application Ser. No. 10/968,586 filed Oct. 19, 2004, which claims the benefit under 35 U.S.C. 119(e) of U.S. Provisional Application Ser. No. 60/512,716, filed Oct. 20, 2003.
- Various embodiments of the present invention relate to an apparatus for vertebral body replacement and methods associated therewith.
- In one embodiment, a vertebral body replacement apparatus may be used to correct and stabilize the spine (e.g., the thoracolumbar spine (T1-L5)).
- In another embodiment, a vertebral body (e.g., a diseased and/or damaged vertebral body) that has been resected or excised (e.g., for the treatment of a tumor or trauma) may be replaced (with the height of the resected or excised vertebral body being substantially replaced and restored by the apparatus of the present invention).
- Examples of various patent documents in the spinal implant area include the following:
- U.S. Pat. No. 5,192,327 to Brantigan relates to a surgical prosthetic implant for vertebrae. More particularly, surgical prosthetic modular implants used singularly or stacked together are provided to support and fuse together adjacent vertebrae or to totally or partially replace one or more vertebrae in a vertebral column. The implants are rigid annular plugs, dimensionally similar to normal vertebral bodies, have simplified oval or hemi-oval shapes with ridged faces to engage adjacent vertebral bodies to resist displacement and allow bone ingrowth and fusion and to interdigitate with the ridges of an adjacent plug for modular stacking to allow variability of ultimate implant height. The implants can be provided in sets of different thicknesses and are internally grooved to receive an upstanding connecting bar to bind together the individual stacked implants into a stable unit. The annular implants have ample spaces to allow ingrowth of blood capillaries and packing of bone graft and are preferably made of a radiolucent material, preferably biocompatible carbon fiber reinforced polymers or are alternately made of traditional orthopaedic implant materials such as nickel, chromium, cobalt, stainless steel or titanium.
- U.S. Pat. No. 5,397,364 to Kozak et al. relates to an anterior interbody fusion device. More particularly, an interbody fusion device includes a pair of lateral spacers and a pair of central spacers, each sized for percutaneous introduction through a disc resection portal in the disc annulus. Each of the lateral spacers includes opposing side faces defining a channel therein, while each of the central spacers includes arms at their opposite ends configured to be received within a channel of a corresponding lateral spacer. The arms and channels are interlocking to prevent separation of the components once assembled within the intradiscal space. The assembly of the central and lateral spacers defines a cavity therebetween for insertion of bone graft material. The central and lateral spacers are configured so that the bone graft cavity is oriented over the weakest, but most vascular and biologically active, bone of the vertebral body, while the lateral spacers are situated adjacent the disc annulus and over the strongest vertebral bone.
- U.S. Pat. No. 6,159,211 to Boriani et al. relates to a stackable cage system for corpectomy/vertebrectomy. More particularly, surgical prosthetic modular devices used singularly or stacked together are provided for use to replace excised vertebral tissue. The devices are rigid plugs, dimensionally similar to normal vertebral bodies, and have ridged faces to engage adjacent vertebral bodies or to interdigitate when stacked. Ridges extend in both the medial/lateral and anterior/posterior directions to prevent slipping in the anterior/posterior and medial/lateral directions respectively. A locking screw may be used to secure a stack to form a singular rigid prosthetic device. The devices are also provided with a plurality of threaded openings. In the method of this invention, a device is used to replace excised vertebral tissue, threaded bolts are inserted into the threaded openings, and other spine stabilization devices are attached to the bolts. In corporectomies, the device can be bolted to a plate, which in turn is fixed to adjacent vertebrae. In spondylectomies, the device can be fixed to a series of posteriorly placed rods.
- U.S. Pat. No. 6,468,311 to Boyd et al. relates to a modular interbody fusion implant. More particularly, an interbody fusion device for engagement between vertebrae includes a pair of lateral spacers for spacing the vertebrae, and a connecting member adapted to couple together the lateral spacers when inserted between the vertebrae. The connecting member, individual lateral spacers, or the entire spinal spacer can be made of bone in order to promote fusion of the vertebrae. The modular construction permits use of bone segments otherwise unsuitable due to size or strength in stable fusion devices.
- U.S. Patent Application No. 2003/0040799 in the name of Boyd et al. relates to a modular interbody fusion implant. More particularly, an interbody fusion device for engagement between vertebrae includes a pair of lateral spacers for spacing the vertebrae, and a connecting member adapted to couple together the lateral spacers when inserted between the vertebrae. The connecting member, individual lateral spacers, or the entire spinal spacer can be made of bone in order to promote fusion of the vertebrae. The modular construction permits use of bone segments otherwise unsuitable due to size or strength in stable fusion devices.
-
FIG. 1 shows a perspective view of one embodiment of a vertebral body replacement implant assembly according to the present invention; -
FIG. 2 shows another view of the implant assembly ofFIG. 1 as it would look outside of the body; -
FIGS. 3A and 3B show exploded perspective views of the implant assembly ofFIGS. 1 and 2 (FIG. 3A shows an embodiment of the implant assembly from one angle andFIG. 3B shows an embodiment of the implant assembly from another angle); -
FIG. 4 shows a perspective view of an endplate type component of an implant assembly according to an embodiment of the present invention; -
FIG. 5 shows a perspective view of a non-lordotic lateral spacer type component of an implant assembly according to an embodiment of the present invention; -
FIG. 6 shows a perspective view of a lordotic lateral spacer type component of an implant assembly according to an embodiment of the present invention; -
FIG. 7 shows a plan view of an implant assembly according to an embodiment of the present invention; -
FIG. 8 shows section A-A ofFIG. 7 ; -
FIG. 9 shows Detail B ofFIG. 8 ; -
FIG. 10 shows a plan view of another embodiment of the present invention; -
FIGS. 11-14 show perspective views of other embodiments of the present invention; -
FIGS. 15 and 16 show, respectively, a perspective view and an exploded perspective view of another embodiment of the present invention; -
FIGS. 17A-17G show perspective views of various components according to an embodiment of the present invention; -
FIGS. 18, 19A , 19B, 20A, 20B and 21 show perspective views of various implant assemblies using the components ofFIGS. 17A-17G ; -
FIGS. 22A-22E show various views of an implant assembly using the components ofFIGS. 17A-17G ; -
FIG. 23 shows a perspective view of another embodiment of a vertebral body replacement implant assembly according to the present invention; -
FIG. 24 shows another view of the implant assembly ofFIG. 23 as it would look outside of the body; -
FIG. 25 shows an exploded perspective view of the implant assembly ofFIGS. 23 and 24 ; -
FIG. 26 shows a perspective view of an endplate type component of an implant assembly according to an embodiment of the present invention; -
FIG. 27 shows a perspective view of a non-lordotic lateral spacer type component of an implant assembly according to an embodiment of the present invention; -
FIG. 28 shows a perspective view of a lordotic lateral spacer type component of an implant assembly according to an embodiment of the present invention; -
FIG. 29 shows a plan view of an implant assembly according to an embodiment of the present invention; -
FIG. 30 shows section B-B ofFIG. 29 ; and -
FIG. 31 shows Detail C ofFIG. 30 . - Among those benefits and improvements that have been disclosed, other objects and advantages of this invention will become apparent from the following description taken in conjunction with the accompanying figures. The figures constitute a part of this specification and include illustrative embodiments of the present invention and illustrate various objects and features thereof.
- Detailed embodiments of the present invention are disclosed herein; however, it is to be understood that the disclosed embodiments are merely illustrative of the invention that may be embodied in various forms. In addition, each of the examples given in connection with the various embodiments of the invention are intended to be illustrative, and not restrictive. Further, the figures are not necessarily to scale, some features may be exaggerated to show details of particular components. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a representative basis for teaching one skilled in the art to variously employ the present invention.
- Referring now to
FIG. 1 , one embodiment of a vertebral body replacement implant assembly according to the present invention is shown. As seen in thisFIG. 1 ,Implant Assembly 101 may be implanted between First Vertebra 103 a and Second Vertebra 103 b (FIG. 2 shows another view ofImplant Assembly 101 as it would look outside of the body). Of note,Implant Assembly 101 may be formed of a number of components fitted together. - More particularly, as seen in
FIGS. 3A and 3B ,Implant Assembly 101 may be formed of, for example, four components: (a) First Endplate 301 (e.g., a top Endplate), Second Endplate 303 (e.g., a bottom Endplate),First Lateral Spacer 305 andSecond Lateral Spacer 307. -
First Endplate 301 may include: First Offset Aperture 301 a (e.g., offset relative to a centerline of Endplate 301); Second Offset Aperture 301 b (e.g., offset relative to a centerline of Endplate 301); Protrusions 301 c and 301 d (these Protrusions are seen most clearly inFIG. 3B ; although in this embodiment there are four such Protrusions (two adjacent First Offset Aperture 301 a and two adjacent Second Offset Aperture 301 b) any number of protrusions may be utilized); InsertionTool Mating Aperture 301 e (for mating with an insertion tool (not shown)); and various grooves disposed along the top surface (the grooves are not separately numbered in the Figs.). - Likewise,
Second Endplate 303 may include: First Offset Aperture 303 a (e.g., offset relative to a centerline of Endplate 303); Second OffsetAperture 303 b (e.g., offset relative to a centerline of Endplate 303); Protrusions 303 c-303 f; Insertion Tool Mating Aperture 303 g (for mating with an insertion tool (not shown)); and various grooves disposed along the bottom surface (the grooves are not separately numbered in the Figs.). - Further,
First Lateral Spacer 305 may include: Main Aperture 305 a (which may at least partially line-up with First Offset Aperture 301 a and First Offset Aperture 303 a; various Auxiliary Apertures (not separately numbered in the Figs.); and various grooves disposed along the top surface and the bottom surface (the grooves are not separately numbered in the Figs.). - Likewise,
Second Lateral Spacer 307 may include: Main Aperture 307 a (which may at least partially line-up with Second Offset Aperture 301 b and Second OffsetAperture 303 b; various Auxiliary Apertures (not separately numbered in the Figs.); and various grooves disposed along the top surface and the bottom surface (the grooves are not separately numbered in the Figs.). - Of note, the embodiments of
FIGS. 3A and 3B are similar, with the main differences being the shape of the internal centerline bosses on the inner faces of the First Endplate and Second Endplate and the fact that the Protrusions in the embodiment ofFIG. 3A are essentially featureless (such that they provide lateral alignment/support) while the Protrusions of the embodiment ofFIG. 3B provide locking features such as the ridges shown in the Fig. but not separately numbered (such that the ridges cooperate with mating indentations (shown in the Fig. but not separately numbered) in the First Lateral Spacer and the Second Lateral Spacer to provide both lateral alignment/support as well as up-down locking (e.g., removable locking) of the components). In another example (which example is intended to be illustrative and not restrictive), a tab and slot system may be utilized for locking. - Of further note,
Implant Assembly 101 may provide for bony ingrowth and/or may be packed with bone matter. This may be accomplished via the hollow fenestrated design of the components (e.g., via First Offset Aperture 301 a; Second Offset Aperture 301 b; First Offset Aperture 303 a; Second OffsetAperture 303 b; Main Aperture 305 a; Main Aperture 307 a; and/or the various Auxiliary Apertures) and/or the hollow fenestrated design of the finished implant assembly (e.g., via the space(s) betweenFirst Lateral Spacer 305 andSecond Lateral Spacer 307 at each end of the finished implant assembly). - In one set of examples (which examples are intended to be illustrative and not restrictive),
Implant Assembly 101 may be provided in two footprint sizes. The “small” footprint may measure, for example, 28 mm wide×23 mm length (in this example each “small” footprint size Endplate may be 28 mm wide×23 mm length, and each Lateral Spacer may be 8 mm wide×23 mm length). The “large” footprint may measure, for example, 35 mm wide×28 mm length (in this example each “large” footprint size Endplate may be 35 mm wide×28 mm length, and each Lateral Spacer may be 8 mm wide×28 mm length). One or both footprint sizes may be available in height ranges from, for example, 12 mm to 60 mm (in increments of one millimeter, for example). - Reference will now be made to Tables 1-3, below, which identify example thicknesses of the components of a “large” implant assembly (of course, these examples are intended to be illustrative and not restrictive). More particularly, Table 1 identifies example thicknesses of a “large” End Plate (see, e.g.,
FIG. 4 for a perspective view of this type of component), Table 2 identifies example thicknesses of a “large” Non-Lordotic Lateral Spacer (see, e.g.,FIG. 5 for a perspective view of this type of component) and Table 3 identifies example thicknesses of a “large” Lordotic Lateral Spacer (see, e.g.,FIG. 6 for a perspective view of this type of component).TABLE 1 (All measurements in mm) 2 3 4 -
TABLE 2 (All measurements in mm) 8 10 12 14 16 21 26 31 36 41 46 51 56 -
TABLE 3 (All measurements in mm) 8 10 12 14 16 21 26 31 36 41 46 51 56 - Reference will now be made to Tables 4-6, below, which identify example thicknesses of the components of a “small” implant assembly (of course, these examples are intended to be illustrative and not restrictive). More particularly, Table 4 identifies example thicknesses of a “small” End Plate (see, e.g.,
FIG. 4 for a perspective view of this type of component), Table 5 identifies example thicknesses of a “small” Non-Lordotic Lateral Spacer (see, e.g.,FIG. 5 for a perspective view of this type of component) and Table 6 identifies example thicknesses of a “small” Lordotic Lateral Spacer (see, e.g.,FIG. 6 for a perspective view of this type of component).TABLE 4 (All measurements in mm) 2 3 4 -
TABLE 5 (All measurements in mm) 8 10 12 14 16 21 26 31 36 41 46 51 56 -
TABLE 6 (All measurements in mm) 8 10 12 14 16 21 26 31 36 41 46 51 56 - Referring now to construction of the implant assembly from its constituent components, it is noted that in one embodiment such construction may occur outside of the patient's body (e.g., outside of the wound). More particularly, after determining the correct height, footprint and/or lordotic requirement of the implant assembly, the surgeon may then select one or more lateral spacers (e.g., two) and/or one or more endplates (e.g., two) that would meet the requirements (e.g., a 30 mm tall implant assembly may utilize two lateral spacers of 26 mm tall and two 2 mm thick endplates). The components may be assembled by snapping the lateral spacers onto a first endplate and then snapping a second endplate onto the two lateral spacers. Such snapping construction may be carried out, for example, using a lip and undercut arrangement (see
FIG. 7 (showing a plan view of an implant assembly according to an embodiment of the present invention),FIG. 8 (showing section A-A ofFIG. 7 ), andFIG. 9 (showing Detail B ofFIG. 8 )). More particularly, with regard to such snapping construction, attention is directed to the features ofFIG. 9 which show the undercut in the lateral spacer and the tapered lip on the endplate (wherein an interference may exist in the assembly until the tapered lip reaches the undercut and snaps into place creating a lock). - In another embodiment, some or all of the components may include or be made essentially entirely from polyetheretherketone (e.g., PEEK Optima). Of note, this PEEK polymer material has radiolucent properties, which may aid the surgeon in determining if fusion (e.g., in the operative site) has occurred. Since such PEEK material is essentially transparent to x-rays, markers (e.g., markers made of titanium) may be inserted into one or more of the components to give a surgeon a visual aid in determining the location of the component and/or entire implant assembly (e.g., both inter and postoperatively).
- In another embodiment, Indications relating to use of the present invention may include (but not be limited to):
-
- For use in thoracolumbar spine (i.e., T1 to L5) to replace a vertebral body (e.g., a diseased vertebral body) resected or excised (e.g., for the treatment of tumor(s)) to achieve anterior decompression of the spinal cord and neural tissues, and to restore the height of a collapsed vertebral body.
- For treating fracture(s) of the thoracic and/or lumbar spine.
- To restore the biomechanical integrity of the anterior, middle, and/or posterior spinal column (e.g., even in the absence of fusion for a prolonged period).
- For use with supplemental internal fixation. Such supplemental internal fixation may include (but not be limited to) any appropriate screws, rods, staples, washers, cross connectors, and/or posterior hooks.
- In another embodiment, Contraindications relating to use of the present invention may include (but not be limited to):
-
- Morbid obesity
- Mental illness
- Alcoholism and/or drug abuse
- Pregnancy
- Mental sensitivity/allergies
- Severe osteopenia
- Patients unwilling or unable to follow post-operative care instructions
- Certain circumstances not identified above as an Indication (e.g., as identified by any appropriate care giver)
- In another embodiment, one or more of the components and/or the implant assembly may have a tapered lead-in (e.g., for easy insertion).
- In another embodiment, each lateral spacer may be capable of supporting the vertebral column.
- In another embodiment, the textured surface of the components and/or the implant assembly may allow for easy insertion and/or resistance to expulsion (see
FIGS. 10-14 for additional textured surface examples (which examples are intended to be illustrative and not restrictive)). - In another embodiment, multiple lateral spacer type components may be assembled in a “bridge” configuration (see
FIGS. 15 and 16 , for example). - In another embodiment, the components may be assembled as desired (see
FIGS. 17A-17G , 18, 19A, 19B, 20A, 20B, 21 and 22A-22E, for example). - Referring now to
FIG. 23 , another embodiment of a vertebral body replacement implant assembly according to the present invention is shown. As seen in thisFIG. 23 ,Implant Assembly 2301 may be implanted betweenFirst Vertebra 2303 a and Second Vertebra 2303 b (FIG. 24 shows another view ofImplant Assembly 2301 as it would look outside of the body). Of note,Implant Assembly 2301 may be formed of a number of components fitted together. - More particularly, as seen in
FIG. 25 ,Implant Assembly 2301 may be formed of, for example, four components: (a) First Endplate 2501 (e.g., a top Endplate), Second Endplate 2503 (e.g., a bottom Endplate),First Lateral Spacer 2505 andSecond Lateral Spacer 2507. -
First Endplate 2501 may include: First Offset Aperture 2501 a (e.g., offset relative to a centerline of Endplate 2501); Second Offset Aperture 2501 b (e.g., offset relative to a centerline of Endplate 2501);Protrusions 2501 c and 2501 d (these Protrusions are not seen in this Fig. but are similar to the Protrusions ofSecond Endplate 2503 discussed below—although in this embodiment there are four such Protrusions (two adjacent First Offset Aperture 2501 a and two adjacent Second Offset Aperture 2501 b) any number of protrusions may be utilized); Insertion Tool Mating Aperture 2501 e (for mating with an insertion tool (not shown)); and various grooves disposed along the top surface (the grooves are not separately numbered in the Figs.). - Likewise,
Second Endplate 2503 may include: First Offset Aperture 2503 a (e.g., offset relative to a centerline of Endplate 2503); Second Offset Aperture 2503 b (e.g., offset relative to a centerline of Endplate 2503); Protrusions 2503 c-2503 f; Insertion Tool Mating Aperture 2503 g (for mating with an insertion tool (not shown)); and various grooves disposed along the bottom surface (the grooves are not separately numbered in the Figs.). - Further,
First Lateral Spacer 2505 may include: Main Aperture 2505 a (which may at least partially line-up with First Offset Aperture 2501 b and First Offset Aperture 2503 b; various Auxiliary Apertures (not separately numbered in the Figs.); and various grooves disposed along the top surface and the bottom surface (the grooves are not separately numbered in the Figs.). - Likewise,
Second Lateral Spacer 2507 may include: Main Aperture 2507 a (which may at least partially line-up with Second Offset Aperture 2501 a and Second Offset Aperture 2503 a; various Auxiliary Apertures (not separately numbered in the Figs.); and various grooves disposed along the top surface and the bottom surface (the grooves are not separately numbered in the Figs.). - Of note, the embodiments of
FIGS. 25 and 3 A/3B are similar, with the main differences being that in the embodiment ofFIG. 25 each ofFirst Endplate 2501 andSecond Endplate 2503 includes pockets into which each ofFirst Lateral Spacer 2505 andSecond Lateral Spacer 2507 fits (Pockets 2503 h and 2503 i are individually identified inFIG. 25 in connection withSecond Endplate 2503—First Endplate 2501 has similar pockets which are not seen in this view). - In one example (which example is intended to be illustrative and not restrictive), the pockets may provide (either alone or in combination with the protrusions) lateral alignment/support of the components. In another example (which example is intended to be illustrative and not restrictive), the pockets may provide (either alone or in combination with the protrusions) both lateral alignment/support of the components as well as up-down locking (e.g., removable locking) of the components. In another example (which example is intended to be illustrative and not restrictive), a tab and slot system may be utilized for locking.
- Of further note,
Implant Assembly 2301 may provide for bony ingrowth and/or may be packed with bone matter. This may be accomplished via the hollow fenestrated design of the components (e.g., via First Offset Aperture 2501 a; Second Offset Aperture 2501 b; First Offset Aperture 2503 a; Second Offset Aperture 2503 b; Main Aperture 2505 a; Main Aperture 2507 a; and/or the various Auxiliary Apertures) and/or the hollow fenestrated design of the finished implant assembly (e.g., via the space(s) betweenFirst Lateral Spacer 2505 andSecond Lateral Spacer 2507 at each end of the finished implant assembly). - Referring now to
FIGS. 26-28 , it is noted that these Figs. show, respectively, a perspective view of an endplate according to an embodiment of the present invention, a perspective view of a non-lordotic lateral spacer according to an embodiment of the present invention and a perspective view of a lordotic lateral spacer according to an embodiment of the present invention. - Referring now to construction of the implant assembly it is noted, as discussed above, that the lateral spacers may be snapped onto a first endplate and then a second endplate may be snapped onto the two lateral spacers. Such snapping construction may be carried out, for example, using a lip and undercut arrangement (see
FIG. 29 (showing a plan view of an implant assembly according to an embodiment of the present invention),FIG. 30 (showing section B-B ofFIG. 29 ), andFIG. 31 (showing Detail C ofFIG. 30 )). More particularly, with regard to such snapping construction, attention is directed to the features ofFIG. 31 which show the undercut in the lateral spacer and the tapered lip on the endplate (wherein an interference may exist in the assembly until the tapered lip reaches the undercut and snaps into place creating a lock). - While a number of embodiments of the present invention have been described, it is understood that these embodiments are illustrative only, and not restrictive, and that many modifications may become apparent to those of ordinary skill in the art. For example, an implant assembly according to the present invention may be tested in accordance with ASTM F 2077-03 “Test Methods For Intervertebral Body Fusion Devices” (or a modified version thereof) and/or the FDA's Sep. 27, 2000 “Guidance for Spinal Systems 510(k)'s. Further, the lordotic angle may be any desired angle (e.g., 4°-8°). Further still, one or more components may be used separately from an implant assembly (e.g., one or more of the lateral spacers (non-lordotic and/or lordotic) may be implanted directly into the spine without use of a top and/or bottom endplate). Further still, the various components may take different shapes as desired and the various features may take on various specifics as desired (e.g., the various apertures may be of any desired number and/or shape). Further still, the apparatus (and/or its components) may, of course, have any desired dimensions (e.g., for any desired patient—man, woman or child). Further still, the apparatus (and/or its components) may be provided in a “line” or “family” of devices (e.g., small, medium and large; adult, child; male, female). Further still, the apparatus (and/or its components) may be provided in standard sizes. Further still, any desired locking mechanism(s) may be used to hold the various components together and/or in desired alignment. Further still, such locking may be capable of being unlocked (e.g., a mechanism and/or tool may be provided for unlocking the various components). Further still, lateral spacers(s) may be disposed adjacent one or more central spacers. Further still, any steps relating to manufacture and/or use may be performed in any desired order.
Claims (31)
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AU2004284933A1 (en) | 2005-05-12 |
WO2005041816A2 (en) | 2005-05-12 |
MXPA06004374A (en) | 2006-07-06 |
US20050154459A1 (en) | 2005-07-14 |
EP1684674A4 (en) | 2011-04-27 |
US7776093B2 (en) | 2010-08-17 |
CA2542833A1 (en) | 2005-05-12 |
WO2005041816A3 (en) | 2006-05-11 |
JP2013027797A (en) | 2013-02-07 |
JP5175049B2 (en) | 2013-04-03 |
JP2007508908A (en) | 2007-04-12 |
EP1684674A2 (en) | 2006-08-02 |
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