US20050171606A1 - Method for installation of manufactured implants shaped to conform to a prepared implantation space - Google Patents
Method for installation of manufactured implants shaped to conform to a prepared implantation space Download PDFInfo
- Publication number
- US20050171606A1 US20050171606A1 US11/089,086 US8908605A US2005171606A1 US 20050171606 A1 US20050171606 A1 US 20050171606A1 US 8908605 A US8908605 A US 8908605A US 2005171606 A1 US2005171606 A1 US 2005171606A1
- Authority
- US
- United States
- Prior art keywords
- bone
- implant
- spinal implant
- combination
- step includes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/4465—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
- A61F2002/30787—Plurality of holes inclined obliquely with respect to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30841—Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30891—Plurality of protrusions
- A61F2002/30892—Plurality of protrusions parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30904—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves serrated profile, i.e. saw-toothed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
Definitions
- the diaphysis is the shaft of a long bone, as distinguished from the epiphysis, the end of the bone forming the joints.
- a complete bone ring is formed with the medulary canal forming an opening through the ring.
- Such rings are generally harvested from femurs for use in the lumbar spine.
- Other bones from the arm or leg or other part of the skeleton may be useful in various regions of the spine.
- diaphyseal bone rings such as those harvested from human femurs
- femoral rings are formed by making two spaced apart cuts approximately perpendicular to the long axis of the diaphyseal portion of a human cadaveric femur. The cuts are generally spaced apart so as to form a ring having a height corresponding to the restored disc space or slightly greater.
- Femoral ring bone grafts are placed into the spine within and across the height of the space previously occupied by a spinal disc between adjacent vertebral bodies to achieve interbody fusion of those vertebral bodies through the disc space. The femoral ring bone graft is incorporated into the bony fusion over time.
- Bone rings that are entirely or almost entirely made of cortical bone offer the advantages of that material including an appropriate modulus of elasticity and strength for the prescribed use, the capacity to be bioactive, including being osteoconductive, osteoinductive, osteogenic, and to more generally provide a good substrate for the formation of new bone as fusion occurs. Further, by being bioabsorable the bone material is replaced by the patient's own bone over time, thereby preventing stress shielding and leading to the eventual elimination of any foreign body from the implantation site.
- the present invention is directed to a major long bone ring implant preferably, but not necessarily, an implant formed from a diaphyseal ring for insertion into an implantation space formed across a spinal disc between two adjacent vertebral bodies of the spine.
- the bone ring implant is preferably used in an implantation space having a wall portion, lip, or ridge with a flat portion for abutting the leading end of the bone ring implant.
- Such an implantation space can be formed with the instrumentation and method set forth in applicant's U.S. application Ser. No. 08/688,758, titled “Milling Instrumentation and Method for Preparing a Space Between Adjacent Vertebral Bodies”, incorporated by reference herein.
- the bone ring implant of the present invention can be useful in implantation spaces formed by other techniques, such as for example, applicant's U.S. application Ser. No. 09/490,901, titled “Instrument And Method For Creating An Intervertebral Space For Receiving An Implant”, incorporated by reference herein.
- the bone ring implant is manufactured and machined to have a leading end and a trailing end opposite the leading end connected by opposed sides or walls.
- the leading end, trailing end, and the opposed sides or walls preferably form one continuous perimeter having opposed upper and lower vertebral body engaging surfaces.
- the bone ring implants of the present invention have a substantial flat portion at the leading end formed by cutting or machining the perimeter of the bone to create a straight cut portion at the leading end.
- the straight cut portion is generally oriented at 90° to the mid-longitudinal axis of the bone ring implant as defined by a line passing through the center of the bone ring implant from its leading end to its trailing end.
- the bone ring implant is further machined so that one and preferably both of the opposed sides have portions that are straight and at a 90° angle to the straight cut portion of the leading end to produce straight portions that are outwardly facing. These straight portions are generally oriented parallel to the implant's longitudinal axis.
- the opposed sides may be machined to be generally parallel to each other over at least a portion of the sides and may be aligned or offset from each other along the implant sides.
- the present invention consists of the unique machined structures of the bone ring implant, as well as may be used in combination with lockable screws, and preferably screw locks each preferably made of cortical bone or of a bioresorbable material.
- the bone ring implant of the present invention may be machined so as to be adapted to receive through its trailing end at least a pair of opposed appropriately sized bone screws preferably, but not necessarily, made of cortical bone.
- the bone engaging screws may be aligned or offset from each other. At least one screw engages each of the vertebral bodies adjacent a disc space to be fused and into which the bone ring implant is implanted.
- the bone ring implant of the present invention is preferably further machined and adapted to receive locks, preferably made of cortical bone, at the trailing end for securing the bone engaging screws therein and preventing the screws from backing out.
- the bone ring implant, bone screws, and/or locks can be made of a bioresorbable material, including but not limited to cortical bone, plastics and composite plastics. Suitable plastics may include those comprising lactides, galactides, glycolide, capronlactone, trimethylene carbonate, or dioxanone in various polymers, and/or combinations thereof.
- the bone ring implant of the present invention can be further machined to have a specialized bone engaging surface configuration designed to enhance stability and resist motion imparted to each of the opposed upper and lower vertebrae engaging surfaces of the bone ring implant, such as for example the surface described in applicant's U.S. application Ser. No. 09/457,228 titled “Spinal Implant Surface Configuration” incorporated by reference herein.
- the bone ring implant of the present invention is preferably for anterior implantation into the disc space and is preferably taller at the trailing end than at the leading end (the leading end being adapted to introduce the implant into the spine) so as to provide for a desired amount of lordosis.
- the bone ring implant has been described as diaphyseal rings by way of example of one embodiment of the present invention. It should be clearly understood that such rings may be formed of bone that may be at least in part metaphyseal if sufficiently strong for the intended purpose.
- the bone ring implants may be made of a manufactured bone composite comprising of particles or filaments of bone and a bioresorbable plastic or ceramic or other suitable material without departing from the inventive concepts of the present invention, prime of which is a manufactured implant comprising cortical bone with a flat leading portion and preferably at least partial side portions that are flat and preferably 90° to the front of the implant.
- FIG. 1 is a top plan view of a vertebral body with preferably a machined implantation socket created therein for receiving a bone ring implant in accordance with the present invention.
- FIG. 2A is a top plan view of a vertebral body showing the desired implantation socket with a first bone ring implant with a bone-engaging surface formed thereon and showing the machining of the bone ring required to obtain that ring's best fit to the recipient site (socket) within that vertebral body.
- FIG. 2B is a top plan view of a vertebral body showing the desired implantation socket with a second bone ring implant with the bone-engaging surface formed thereon and showing the machining of the bone ring required to obtain that ring's best fit to the recipient site (socket) within that vertebral body.
- FIG. 3A is an enlarged fragmentary view along line 3 - 3 of FIG. 2A of the bone-engaging surface.
- FIG. 3B is a side view of FIG. 3A illustrating the configuration of the bone-engaging surface.
- FIG. 4 is a trailing end view of a bone ring implant in accordance with an embodiment of the present invention having openings oriented toward the adjacent vertebral bodies for receiving bone-engaging screws.
- FIG. 5 is a side elevation view of the bone ring implant of FIG. 4 .
- FIG. 6 is a leading end view of the bone ring implant of FIG. 4 .
- FIG. 7 is a trailing end view of a bone ring implant in accordance with a second embodiment of the present invention.
- FIG. 8 is a trailing end view of a bone ring implant in accordance with a third embodiment of the present invention.
- FIG. 9 is a side elevation view of the bone ring implant of FIG. 6 with two bone engaging screws installed.
- FIG. 10 is a top plan view of the bone ring implant of FIG. 6 machined to have a top exit screw hole and a bottom exit screw hole shown in hidden line.
- FIG. 1 shows a top plan view of a vertebral body V with an implantation space 20 created therein for receiving an implant.
- Implantation socket or space 20 has a posterior wall 22 and side walls 24 , 26 formed at least in part in the endplate of vertebral body V.
- implantation space 20 may be created with the apparatus and methods disclosed in applicant's U.S. application Ser. No. 08/688,758.
- FIGS. 2A and 2B show top plan views of vertebral body V and first and second bone ring implants 30 and 40 , respectively, placed thereon with the area of implantation space 20 identified by dotted lines.
- Bone rings can be made from a long bone of the human body, and preferably made from a human femur.
- First and second bone ring implants 30 , 40 have outer perimeters that are intact and not modified from their naturally occurring state such as in a human femur. Bone ring implants 30 , 40 in their natural state do not fit properly within the prepared implantation space 20 bordered by posterior wall 22 and side walls 24 , 26 illustrated by the dotted lines.
- Bone ring implant 30 has sides that extend beyond side walls 24 , 26 and a leading end 32 that extends beyond posterior wall 22 of implantation space 20 and protrudes from the posterior aspect of vertebral body V.
- leading end 42 extends beyond posterior wall 22 and has sides that extend beyond side walls 24 , 26 of implantation space 20 .
- FIG. 3A shows an enlarged fragmentary view of a bone-engaging surface 50 that can be formed on bone ring implants described herein to increase the stability of the bone ring implants installed between two adjacent vertebral bodies.
- FIG. 3B is a side view of FIG. 3A illustrating the configuration of a preferred embodiment of bone-engaging surface 50 .
- Bone engaging surface 50 has a forward facet 52 facing the leading end of the bone ring implant, an opposite rearward portion 54 facing the trailing end of the bone ring implant, and opposed side facets 56 , 58 directed generally toward the sides of the bone ring implant.
- Bone engaging surface 50 preferably facilitates motion in the direction of insertion and preferably resists motion in all other directions, including the direction opposite to the direction of insertion. While the specialized bone-engaging surface 50 is preferred, in the alternative the surfaces of the bone ring can be roughened, ratcheted, knurled, or otherwise modified when it is desired to increase the resistance of the bone ring implant to motion.
- FIGS. 4-10 show a bone ring implant 100 in accordance with various preferred embodiments of the present invention.
- Bone ring implant 100 has a leading end 102 for insertion into the implantation space, an opposite trailing end 104 , opposed upper and lower surfaces 106 , 108 , and opposed sides, 110 , 112 therebetween.
- Upper and lower surfaces 106 , 108 include a medulary canal 114 passing therethrough which may be useful to permit for the growth of bone from adjacent vertebral body to adjacent vertebral body through the medulary canal 114 in bone ring implant 100 , which can to that end be filled with fusion promoting substances.
- Upper and lower surfaces 106 , 108 may also be porous or include a bone ingrowth surface.
- leading end 102 and opposed sides 110 , 112 are machined to configure bone ring implant 100 to conform to the shape of prepared implantation space 20 .
- Leading end 102 and sides 110 , 112 can be machined to have a more planar configuration to abut posterior wall 22 and side walls 24 , 26 , respectively, of implantation space 20 .
- the machined surfaces of leading end 102 and opposed sides 110 , 112 are separated by the natural contour of the bone ring.
- the bone ring implant 100 can be machined so either or both of sides 110 , 112 are at a 90° angle to the straight cut portion of leading end 102 to produce straight portions outwardly facing and generally parallel to each other, that can be aligned or offset from each other along sides 110 , 112 .
- the bone ring implant can be manufactured from a composite of cortical fibers, filaments, particles, and a material which may or may not be bioactive and/or bioresorbable such as a plastic, ceramic, for example. Once formed, the composite implant material may be machined or molded, into the desired shape.
- trailing end 104 can be machined to include openings 120 , 122 for receiving bone-engaging screws 130 a , 130 b .
- Openings 120 , 122 extend from trailing end 104 through upper and lower surfaces 106 , 108 , respectively, and are preferably oriented or directed toward the adjacent vertebral bodies.
- trailing end 104 can include openings 132 , 134 , 136 , 138 , for receiving bone-engaging screws.
- Openings 132 , 134 , 136 , 138 can be oriented toward upper and lower surfaces 106 , 108 in an alternating manner as shown in FIG. 7 .
- openings 132 , 138 can be oriented toward upper surface 106 and openings 134 , 136 can be oriented toward lower surface 108 as shown in FIG. 8 , or any combination thereof.
- the number of openings in trailing end 104 can vary depending on the size of the implant and the number of screws desired to be utilized by the surgeon.
- the medulary canal 114 of bone ring implant 100 may be loaded with fusion promoting substances and/or the implant may be treated with fusion promoting substances.
- Such substances may include, but are not limited to, bone morphogenetic protein (BMP), genetic material coding for the production of bone, mineralizing proteins, bone or bone products, a chemical substance to inhibit scar formation, and other materials.
- BMP bone morphogenetic protein
- the medulary canal 114 which may or may not be machined, is compressively loaded with what is at least in part fusion promoting substances to increase the density of the filled area. Potentially, this allows for an increase in the quantities of fusion promoting material and provides the ability of the filled area to bear load.
- the bone ring implants, bone screws, or locks could include a bioresorbable material including, but not limited to cortical bone, plastics and composite plastics.
- Suitable plastics may include those comprising lactides, galactides, glycolide, capronlactone, trimethylene carbonate, dioxanone in various polymers and/or combinations.
- the present invention has been described as being an improved ring of bone harvested from the diaphyseal region of a long bone. This has been done to emphasize that the implant should have a substantial ring or perimeter of cortical bone. It is not necessary that the perimeter of cortical bone be uninterrupted or complete.
- the perimeter of the bone ring implant may include an open portion adapted to provide access to the medulary canal 114 . Further, the implant could rely on some portion of denser cancellous bone and still conform to the teachings of the present invention.
- the present invention can include bone harvested from the area of the diaphyseal/metaphyseal transition.
- a graft could be harvested from the metaphyseal region of that bone and machined in accordance with the teachings of the present invention and would be within the scope of the present invention.
- a femoral ring because of its diameter, lends itself well to use in the human adult lumbar spine, other tubular bones may be useful in various locations of a human spine.
- rings formed through the diaphyseal region of a fibula or humerus may be used for interbody fusion in the cervical spine, while a tibial ring may be used in the thoracic or lumbar spine.
- the implants of the present invention may be formed from a composite material comprising cortical bone.
Abstract
Description
- The present application is a divisional of application Ser. No. 09/593,591, filed Jun. 13, 2000, which is incorporated herein by reference.
- The diaphysis is the shaft of a long bone, as distinguished from the epiphysis, the end of the bone forming the joints. When the diaphysis is cut twice, more or less transversely, a complete bone ring is formed with the medulary canal forming an opening through the ring. Such rings are generally harvested from femurs for use in the lumbar spine. Other bones from the arm or leg or other part of the skeleton may be useful in various regions of the spine.
- The use of diaphyseal bone rings, such as those harvested from human femurs, is well known in the art of spinal fusion. For interbody spinal fusion, femoral rings are formed by making two spaced apart cuts approximately perpendicular to the long axis of the diaphyseal portion of a human cadaveric femur. The cuts are generally spaced apart so as to form a ring having a height corresponding to the restored disc space or slightly greater. Femoral ring bone grafts are placed into the spine within and across the height of the space previously occupied by a spinal disc between adjacent vertebral bodies to achieve interbody fusion of those vertebral bodies through the disc space. The femoral ring bone graft is incorporated into the bony fusion over time.
- Interbody spinal fusion with bone rings, however, has had limited success in the past. While all the causes for failure may not yet be appreciated, it is nevertheless believed that a failure to gain congruity at the interfaces of the bone ring implant to the adjacent vertebral bodies, and a failure to achieve stability of the bone ring implant, may be two of the more significant factors subject to the surgeon's control contributing to such failures.
- Bone rings that are entirely or almost entirely made of cortical bone offer the advantages of that material including an appropriate modulus of elasticity and strength for the prescribed use, the capacity to be bioactive, including being osteoconductive, osteoinductive, osteogenic, and to more generally provide a good substrate for the formation of new bone as fusion occurs. Further, by being bioabsorable the bone material is replaced by the patient's own bone over time, thereby preventing stress shielding and leading to the eventual elimination of any foreign body from the implantation site.
- As it is desirable to take advantage of all these benefits, there exists a need for an improved bone ring implant, which when used in accordance with the prescribed method of disc space preparation, provides for an improved congruity of the implant to the vertebral bodies and improved implant stability.
- The present invention is directed to a major long bone ring implant preferably, but not necessarily, an implant formed from a diaphyseal ring for insertion into an implantation space formed across a spinal disc between two adjacent vertebral bodies of the spine. The bone ring implant is preferably used in an implantation space having a wall portion, lip, or ridge with a flat portion for abutting the leading end of the bone ring implant. Such an implantation space can be formed with the instrumentation and method set forth in applicant's U.S. application Ser. No. 08/688,758, titled “Milling Instrumentation and Method for Preparing a Space Between Adjacent Vertebral Bodies”, incorporated by reference herein. It is appreciated however, that the bone ring implant of the present invention can be useful in implantation spaces formed by other techniques, such as for example, applicant's U.S. application Ser. No. 09/490,901, titled “Instrument And Method For Creating An Intervertebral Space For Receiving An Implant”, incorporated by reference herein.
- The bone ring implant is manufactured and machined to have a leading end and a trailing end opposite the leading end connected by opposed sides or walls. In combination the leading end, trailing end, and the opposed sides or walls preferably form one continuous perimeter having opposed upper and lower vertebral body engaging surfaces. By way of example and not limitation, while diaphyseal rings as harvested are generally round or oval, the bone ring implants of the present invention have a substantial flat portion at the leading end formed by cutting or machining the perimeter of the bone to create a straight cut portion at the leading end. The straight cut portion is generally oriented at 90° to the mid-longitudinal axis of the bone ring implant as defined by a line passing through the center of the bone ring implant from its leading end to its trailing end.
- In a preferred embodiment, the bone ring implant is further machined so that one and preferably both of the opposed sides have portions that are straight and at a 90° angle to the straight cut portion of the leading end to produce straight portions that are outwardly facing. These straight portions are generally oriented parallel to the implant's longitudinal axis. The opposed sides may be machined to be generally parallel to each other over at least a portion of the sides and may be aligned or offset from each other along the implant sides. The present invention consists of the unique machined structures of the bone ring implant, as well as may be used in combination with lockable screws, and preferably screw locks each preferably made of cortical bone or of a bioresorbable material.
- The bone ring implant of the present invention may be machined so as to be adapted to receive through its trailing end at least a pair of opposed appropriately sized bone screws preferably, but not necessarily, made of cortical bone. The bone engaging screws may be aligned or offset from each other. At least one screw engages each of the vertebral bodies adjacent a disc space to be fused and into which the bone ring implant is implanted.
- The bone ring implant of the present invention is preferably further machined and adapted to receive locks, preferably made of cortical bone, at the trailing end for securing the bone engaging screws therein and preventing the screws from backing out. The bone ring implant, bone screws, and/or locks can be made of a bioresorbable material, including but not limited to cortical bone, plastics and composite plastics. Suitable plastics may include those comprising lactides, galactides, glycolide, capronlactone, trimethylene carbonate, or dioxanone in various polymers, and/or combinations thereof.
- The bone ring implant of the present invention can be further machined to have a specialized bone engaging surface configuration designed to enhance stability and resist motion imparted to each of the opposed upper and lower vertebrae engaging surfaces of the bone ring implant, such as for example the surface described in applicant's U.S. application Ser. No. 09/457,228 titled “Spinal Implant Surface Configuration” incorporated by reference herein.
- The bone ring implant of the present invention is preferably for anterior implantation into the disc space and is preferably taller at the trailing end than at the leading end (the leading end being adapted to introduce the implant into the spine) so as to provide for a desired amount of lordosis.
- The bone ring implant has been described as diaphyseal rings by way of example of one embodiment of the present invention. It should be clearly understood that such rings may be formed of bone that may be at least in part metaphyseal if sufficiently strong for the intended purpose. Alternatively, the bone ring implants may be made of a manufactured bone composite comprising of particles or filaments of bone and a bioresorbable plastic or ceramic or other suitable material without departing from the inventive concepts of the present invention, prime of which is a manufactured implant comprising cortical bone with a flat leading portion and preferably at least partial side portions that are flat and preferably 90° to the front of the implant.
-
FIG. 1 is a top plan view of a vertebral body with preferably a machined implantation socket created therein for receiving a bone ring implant in accordance with the present invention. -
FIG. 2A is a top plan view of a vertebral body showing the desired implantation socket with a first bone ring implant with a bone-engaging surface formed thereon and showing the machining of the bone ring required to obtain that ring's best fit to the recipient site (socket) within that vertebral body. -
FIG. 2B is a top plan view of a vertebral body showing the desired implantation socket with a second bone ring implant with the bone-engaging surface formed thereon and showing the machining of the bone ring required to obtain that ring's best fit to the recipient site (socket) within that vertebral body. -
FIG. 3A is an enlarged fragmentary view along line 3-3 ofFIG. 2A of the bone-engaging surface. -
FIG. 3B is a side view ofFIG. 3A illustrating the configuration of the bone-engaging surface. -
FIG. 4 is a trailing end view of a bone ring implant in accordance with an embodiment of the present invention having openings oriented toward the adjacent vertebral bodies for receiving bone-engaging screws. -
FIG. 5 is a side elevation view of the bone ring implant ofFIG. 4 . -
FIG. 6 is a leading end view of the bone ring implant ofFIG. 4 . -
FIG. 7 is a trailing end view of a bone ring implant in accordance with a second embodiment of the present invention. -
FIG. 8 is a trailing end view of a bone ring implant in accordance with a third embodiment of the present invention. -
FIG. 9 is a side elevation view of the bone ring implant ofFIG. 6 with two bone engaging screws installed. -
FIG. 10 is a top plan view of the bone ring implant ofFIG. 6 machined to have a top exit screw hole and a bottom exit screw hole shown in hidden line. - It is an object of an embodiment of the present invention to provide a manufactured bone ring implant having an improved contour and conformation with critical known dimensions.
- It is a further object of an embodiment of the present invention to have the bone ring implant configuration conform, where critical, to an easily and reliably producible shape of an interbody recipient site.
- It is a further object of an embodiment of the present invention to have opposed upper and lower vertebral body engaging surfaces configured to enhance the stability of the bone ring implant relative to the adjacent vertebral bodies when in use.
- In a preferred embodiment of the present invention, it is a further object of the present invention to provide for an improved cortical bone ring implant adapted to receive at least a pair of opposed vertebral body engaging bone screws for further stabilizing the bone ring implant, and for stabilizing the adjacent vertebrae relative to the bone ring implant and to each other.
- It is a further object of an embodiment of the present invention to provide for an interbody spinal fusion implant in the form of an improved ring of diaphyseal bone from a human long bone correspondingly dimensioned for a recipient site across the height of a disc space and in contact with each of the vertebral bodies adjacent that disc space.
- It is a further object of an embodiment of the present invention to provide for an improved bone ring implant adapted to receive screw locks for locking opposed vertebral body engaging bone screws to the bone ring implant to prevent them from backing out.
-
FIG. 1 shows a top plan view of a vertebral body V with animplantation space 20 created therein for receiving an implant. Implantation socket orspace 20 has aposterior wall 22 andside walls implantation space 20 may be created with the apparatus and methods disclosed in applicant's U.S. application Ser. No. 08/688,758. -
FIGS. 2A and 2B show top plan views of vertebral body V and first and secondbone ring implants implantation space 20 identified by dotted lines. Bone rings can be made from a long bone of the human body, and preferably made from a human femur. First and secondbone ring implants Bone ring implants prepared implantation space 20 bordered byposterior wall 22 andside walls Bone ring implant 30 has sides that extend beyondside walls leading end 32 that extends beyondposterior wall 22 ofimplantation space 20 and protrudes from the posterior aspect of vertebral body V. Similarly, whilebone ring implant 40 does not protrude from the posterior aspect of vertebral body V, leadingend 42 extends beyondposterior wall 22 and has sides that extend beyondside walls implantation space 20. -
FIG. 3A shows an enlarged fragmentary view of a bone-engagingsurface 50 that can be formed on bone ring implants described herein to increase the stability of the bone ring implants installed between two adjacent vertebral bodies.FIG. 3B is a side view ofFIG. 3A illustrating the configuration of a preferred embodiment of bone-engagingsurface 50.Bone engaging surface 50 has aforward facet 52 facing the leading end of the bone ring implant, an oppositerearward portion 54 facing the trailing end of the bone ring implant, and opposedside facets Bone engaging surface 50 preferably facilitates motion in the direction of insertion and preferably resists motion in all other directions, including the direction opposite to the direction of insertion. While the specialized bone-engagingsurface 50 is preferred, in the alternative the surfaces of the bone ring can be roughened, ratcheted, knurled, or otherwise modified when it is desired to increase the resistance of the bone ring implant to motion. -
FIGS. 4-10 show abone ring implant 100 in accordance with various preferred embodiments of the present invention.Bone ring implant 100 has aleading end 102 for insertion into the implantation space, an opposite trailingend 104, opposed upper andlower surfaces lower surfaces medulary canal 114 passing therethrough which may be useful to permit for the growth of bone from adjacent vertebral body to adjacent vertebral body through themedulary canal 114 inbone ring implant 100, which can to that end be filled with fusion promoting substances. Upper andlower surfaces - In a preferred embodiment of the present invention, leading
end 102 and opposedsides bone ring implant 100 to conform to the shape ofprepared implantation space 20. Leadingend 102 andsides posterior wall 22 andside walls implantation space 20. In this embodiment, the machined surfaces of leadingend 102 and opposedsides bone ring implant 100 can be machined so either or both ofsides leading end 102 to produce straight portions outwardly facing and generally parallel to each other, that can be aligned or offset from each other alongsides - Alternatively, in another embodiment of the present invention, instead of being machined from a single bone, the bone ring implant can be manufactured from a composite of cortical fibers, filaments, particles, and a material which may or may not be bioactive and/or bioresorbable such as a plastic, ceramic, for example. Once formed, the composite implant material may be machined or molded, into the desired shape.
- As shown in
FIGS. 4, 9 , and 10, in a preferred embodiment of the present invention, trailingend 104 can be machined to includeopenings screws 130 a, 130 b.Openings end 104 through upper andlower surfaces FIGS. 7 and 8 , instead ofopenings end 104 can includeopenings Openings lower surfaces FIG. 7 . Alternatively,openings upper surface 106 andopenings lower surface 108 as shown inFIG. 8 , or any combination thereof. The number of openings in trailingend 104 can vary depending on the size of the implant and the number of screws desired to be utilized by the surgeon. - In a further embodiment of the present invention, the
medulary canal 114 ofbone ring implant 100 may be loaded with fusion promoting substances and/or the implant may be treated with fusion promoting substances. Such substances may include, but are not limited to, bone morphogenetic protein (BMP), genetic material coding for the production of bone, mineralizing proteins, bone or bone products, a chemical substance to inhibit scar formation, and other materials. - In a further embodiment of the present invention, the
medulary canal 114, which may or may not be machined, is compressively loaded with what is at least in part fusion promoting substances to increase the density of the filled area. Potentially, this allows for an increase in the quantities of fusion promoting material and provides the ability of the filled area to bear load. - The bone ring implants, bone screws, or locks could include a bioresorbable material including, but not limited to cortical bone, plastics and composite plastics. Suitable plastics may include those comprising lactides, galactides, glycolide, capronlactone, trimethylene carbonate, dioxanone in various polymers and/or combinations.
- The present invention has been described as being an improved ring of bone harvested from the diaphyseal region of a long bone. This has been done to emphasize that the implant should have a substantial ring or perimeter of cortical bone. It is not necessary that the perimeter of cortical bone be uninterrupted or complete. The perimeter of the bone ring implant may include an open portion adapted to provide access to the
medulary canal 114. Further, the implant could rely on some portion of denser cancellous bone and still conform to the teachings of the present invention. The present invention can include bone harvested from the area of the diaphyseal/metaphyseal transition. If the cancellous density of a specific bone were sufficient for the graft to work in the intended manner, then a graft could be harvested from the metaphyseal region of that bone and machined in accordance with the teachings of the present invention and would be within the scope of the present invention. - While a preferred embodiment of the present invention has been described in regard to a femoral ring modified in accordance with the teachings of the present invention, the invention itself is not so limited. While a femoral ring, because of its diameter, lends itself well to use in the human adult lumbar spine, other tubular bones may be useful in various locations of a human spine. By way of example only and not limitation, rings formed through the diaphyseal region of a fibula or humerus may be used for interbody fusion in the cervical spine, while a tibial ring may be used in the thoracic or lumbar spine. Finally, the implants of the present invention may be formed from a composite material comprising cortical bone.
Claims (18)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/089,086 US20050171606A1 (en) | 2000-06-13 | 2005-03-24 | Method for installation of manufactured implants shaped to conform to a prepared implantation space |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59359100A | 2000-06-13 | 2000-06-13 | |
US11/089,086 US20050171606A1 (en) | 2000-06-13 | 2005-03-24 | Method for installation of manufactured implants shaped to conform to a prepared implantation space |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US59359100A Division | 2000-06-13 | 2000-06-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
US20050171606A1 true US20050171606A1 (en) | 2005-08-04 |
Family
ID=24375333
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/089,086 Abandoned US20050171606A1 (en) | 2000-06-13 | 2005-03-24 | Method for installation of manufactured implants shaped to conform to a prepared implantation space |
US11/089,087 Expired - Fee Related US8105383B2 (en) | 2000-06-13 | 2005-03-24 | Manufactured bone composite implant shaped to conform to a prepared implantation space |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/089,087 Expired - Fee Related US8105383B2 (en) | 2000-06-13 | 2005-03-24 | Manufactured bone composite implant shaped to conform to a prepared implantation space |
Country Status (3)
Country | Link |
---|---|
US (2) | US20050171606A1 (en) |
AU (1) | AU2001274821A1 (en) |
WO (1) | WO2001095837A1 (en) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050171607A1 (en) * | 2000-06-13 | 2005-08-04 | Michelson Gary K. | Manufactured bone composite implant shaped to conform to a prepared implantation space |
US20050267578A1 (en) * | 2000-06-13 | 2005-12-01 | Michelson Gary K | Ratcheted bone dowel having smooth sides and method for use thereof |
US20080200985A1 (en) * | 2007-02-19 | 2008-08-21 | Zimmer Spine, Inc. | Spinal implant |
US20080208342A1 (en) * | 2007-02-27 | 2008-08-28 | Zimmer Spine, Inc. | Spinal implant |
US20090299412A1 (en) * | 2006-02-02 | 2009-12-03 | Trinity Orthopedics | Percutaneous facet joint fusion system and method |
US7736380B2 (en) | 2004-12-21 | 2010-06-15 | Rhausler, Inc. | Cervical plate system |
US20120277862A1 (en) * | 2008-04-04 | 2012-11-01 | Clariance | Nuclear implant |
US8454694B2 (en) | 2011-03-03 | 2013-06-04 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US8480747B2 (en) | 2010-08-11 | 2013-07-09 | Warsaw Orthopedic, Inc. | Interbody spinal implants with extravertebral support plates |
US8540774B2 (en) | 2007-11-16 | 2013-09-24 | DePuy Synthes Products, LLC | Low profile intervertebral implant |
US8828082B2 (en) | 2009-07-09 | 2014-09-09 | R Tree Innovations, Llc | Inter-body implant |
US9254130B2 (en) | 2011-11-01 | 2016-02-09 | Hyun Bae | Blade anchor systems for bone fusion |
US9480511B2 (en) | 2009-12-17 | 2016-11-01 | Engage Medical Holdings, Llc | Blade fixation for ankle fusion and arthroplasty |
US9730804B2 (en) | 2009-09-06 | 2017-08-15 | Warsaw Orthopedic, Inc. | Locking spinal fusion device |
US9848992B2 (en) | 2010-12-21 | 2017-12-26 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US9867718B2 (en) | 2014-10-22 | 2018-01-16 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US9925051B2 (en) | 2010-12-16 | 2018-03-27 | Engage Medical Holdings, Llc | Arthroplasty systems and methods |
US10064740B2 (en) | 2003-02-06 | 2018-09-04 | DePuy Synthes Products, LLC | Intervertebral implant |
US10238382B2 (en) | 2012-03-26 | 2019-03-26 | Engage Medical Holdings, Llc | Blade anchor for foot and ankle |
US10390955B2 (en) | 2016-09-22 | 2019-08-27 | Engage Medical Holdings, Llc | Bone implants |
US10433976B2 (en) | 2008-11-07 | 2019-10-08 | DePuy Synthes Products, Inc. | Zero-profile interbody spacer and coupled plate assembly |
US10456272B2 (en) | 2017-03-03 | 2019-10-29 | Engage Uni Llc | Unicompartmental knee arthroplasty |
US10492922B2 (en) | 2002-02-19 | 2019-12-03 | DePuy Synthes Products, Inc. | Intervertebral implant |
US10512548B2 (en) | 2006-02-27 | 2019-12-24 | DePuy Synthes Products, Inc. | Intervertebral implant with fixation geometry |
US11540928B2 (en) | 2017-03-03 | 2023-01-03 | Engage Uni Llc | Unicompartmental knee arthroplasty |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1230902A1 (en) | 1996-11-15 | 2002-08-14 | Advanced Bio Surfaces, Inc. | Biomaterial system for in situ tissue repair |
US7077864B2 (en) * | 2002-02-12 | 2006-07-18 | Cross Medical Products, Inc. | Vertebral interbody cage with translatable locking screw |
US7819903B2 (en) | 2003-03-31 | 2010-10-26 | Depuy Spine, Inc. | Spinal fixation plate |
US7985255B2 (en) | 2003-04-21 | 2011-07-26 | Rsb Spine Llc | Implant subsidence control |
US20170020683A1 (en) | 2003-04-21 | 2017-01-26 | Rsb Spine Llc | Bone plate stabilization system and method for its use |
US8100976B2 (en) | 2003-04-21 | 2012-01-24 | Rsb Spine Llc | Implant subsidence control |
US9278009B2 (en) | 2003-04-21 | 2016-03-08 | Rsb Spine Llc | Spine implants |
US8613772B2 (en) | 2003-04-21 | 2013-12-24 | Rsb Spine Llc | Lateral mount implant device |
US9044333B2 (en) | 2007-07-27 | 2015-06-02 | R Tree Innovations, Llc | Inter-body implantation system and method |
KR101464983B1 (en) | 2008-05-01 | 2014-11-25 | 스파인셀 프러프라이어테리 리미티드 | System methods and apparatuses for formation and insertion of tissue prothesis |
US8709083B2 (en) | 2009-06-04 | 2014-04-29 | William E. Duffield | Intervertebral fusion implant |
US8328872B2 (en) | 2008-09-02 | 2012-12-11 | Globus Medical, Inc. | Intervertebral fusion implant |
US9155631B2 (en) | 2010-04-08 | 2015-10-13 | Globus Medical Inc. | Intervertbral implant |
US9241809B2 (en) | 2010-12-21 | 2016-01-26 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US9681959B2 (en) | 2011-09-16 | 2017-06-20 | Globus Medical, Inc. | Low profile plate |
US9237957B2 (en) | 2011-09-16 | 2016-01-19 | Globus Medical, Inc. | Low profile plate |
US9539109B2 (en) | 2011-09-16 | 2017-01-10 | Globus Medical, Inc. | Low profile plate |
US10881526B2 (en) | 2011-09-16 | 2021-01-05 | Globus Medical, Inc. | Low profile plate |
US9848994B2 (en) | 2011-09-16 | 2017-12-26 | Globus Medical, Inc. | Low profile plate |
US10245155B2 (en) | 2011-09-16 | 2019-04-02 | Globus Medical, Inc. | Low profile plate |
US9149365B2 (en) | 2013-03-05 | 2015-10-06 | Globus Medical, Inc. | Low profile plate |
US9615856B2 (en) | 2011-11-01 | 2017-04-11 | Imds Llc | Sacroiliac fusion cage |
US20130325071A1 (en) | 2012-05-30 | 2013-12-05 | Marcin Niemiec | Aligning Vertebral Bodies |
US10207027B2 (en) | 2012-06-11 | 2019-02-19 | Globus Medical, Inc. | Bioactive bone graft substitutes |
US9326861B2 (en) | 2012-08-03 | 2016-05-03 | Globus Medical, Inc. | Stabilizing joints |
US10105239B2 (en) | 2013-02-14 | 2018-10-23 | Globus Medical, Inc. | Devices and methods for correcting vertebral misalignment |
US9585765B2 (en) | 2013-02-14 | 2017-03-07 | Globus Medical, Inc | Devices and methods for correcting vertebral misalignment |
US10117754B2 (en) | 2013-02-25 | 2018-11-06 | Globus Medical, Inc. | Expandable intervertebral implant |
US9474622B2 (en) | 2013-03-15 | 2016-10-25 | Globus Medical, Inc | Expandable intervertebral implant |
US9456906B2 (en) | 2013-03-15 | 2016-10-04 | Globus Medical, Inc. | Expandable intervertebral implant |
US9233009B2 (en) | 2013-03-15 | 2016-01-12 | Globus Medical, Inc. | Expandable intervertebral implant |
US9149367B2 (en) | 2013-03-15 | 2015-10-06 | Globus Medical Inc | Expandable intervertebral implant |
US9539103B2 (en) | 2013-03-15 | 2017-01-10 | Globus Medical, Inc. | Expandable intervertebral implant |
US9572677B2 (en) | 2013-03-15 | 2017-02-21 | Globus Medical, Inc. | Expandable intervertebral implant |
US9034045B2 (en) | 2013-03-15 | 2015-05-19 | Globus Medical, Inc | Expandable intervertebral implant |
US9186258B2 (en) | 2013-03-15 | 2015-11-17 | Globus Medical, Inc. | Expandable intervertebral implant |
US9539286B2 (en) | 2013-10-18 | 2017-01-10 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
US9486483B2 (en) | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
US10478313B1 (en) | 2014-01-10 | 2019-11-19 | Nuvasive, Inc. | Spinal fusion implant and related methods |
US9730802B1 (en) | 2014-01-14 | 2017-08-15 | Nuvasive, Inc. | Spinal fusion implant and related methods |
US9579421B2 (en) | 2014-02-07 | 2017-02-28 | Globus Medical Inc. | Bone grafts and methods of making and using bone grafts |
US9463264B2 (en) | 2014-02-11 | 2016-10-11 | Globus Medical, Inc. | Bone grafts and methods of making and using bone grafts |
US11160666B2 (en) | 2014-05-15 | 2021-11-02 | Globus Medical, Inc. | Laterally insertable intervertebral spinal implant |
US9486327B2 (en) | 2014-05-15 | 2016-11-08 | Globus Medical, Inc. | Standalone interbody implants |
US9968461B2 (en) | 2014-05-15 | 2018-05-15 | Globus Medical, Inc. | Standalone interbody implants |
US9545320B2 (en) | 2014-05-15 | 2017-01-17 | Globus Medical, Inc. | Standalone interbody implants |
US9675465B2 (en) | 2014-05-15 | 2017-06-13 | Globus Medical, Inc. | Standalone interbody implants |
AU2015374114B2 (en) | 2014-12-29 | 2018-07-26 | Bioventus, Llc | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
US10531957B2 (en) | 2015-05-21 | 2020-01-14 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
US11426489B2 (en) | 2015-06-10 | 2022-08-30 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
US10016529B2 (en) | 2015-06-10 | 2018-07-10 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
US10034768B2 (en) | 2015-09-02 | 2018-07-31 | Globus Medical, Inc. | Implantable systems, devices and related methods |
US10376385B2 (en) | 2017-04-05 | 2019-08-13 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
US11452608B2 (en) | 2017-04-05 | 2022-09-27 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
Citations (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US245259A (en) * | 1881-08-02 | crompton | ||
US3867728A (en) * | 1971-12-30 | 1975-02-25 | Cutter Lab | Prosthesis for spinal repair |
US4070514A (en) * | 1973-06-05 | 1978-01-24 | The United States Of America As Represented By The United States Department Of Energy | Method of fabricating graphite for use as a skeletal prosthesis and product thereof |
US4309777A (en) * | 1980-11-13 | 1982-01-12 | Patil Arun A | Artificial intervertebral disc |
US4349921A (en) * | 1980-06-13 | 1982-09-21 | Kuntz J David | Intervertebral disc prosthesis |
US4599086A (en) * | 1985-06-07 | 1986-07-08 | Doty James R | Spine stabilization device and method |
US4714469A (en) * | 1987-02-26 | 1987-12-22 | Pfizer Hospital Products Group, Inc. | Spinal implant |
US4743256A (en) * | 1985-10-04 | 1988-05-10 | Brantigan John W | Surgical prosthetic implant facilitating vertebral interbody fusion and method |
US4834757A (en) * | 1987-01-22 | 1989-05-30 | Brantigan John W | Prosthetic implant |
US4863477A (en) * | 1987-05-12 | 1989-09-05 | Monson Gary L | Synthetic intervertebral disc prosthesis |
US4877020A (en) * | 1984-11-30 | 1989-10-31 | Vich Jose M O | Apparatus for bone graft |
US4904261A (en) * | 1987-08-06 | 1990-02-27 | A. W. Showell (Surgicraft) Limited | Spinal implants |
US4911718A (en) * | 1988-06-10 | 1990-03-27 | University Of Medicine & Dentistry Of N.J. | Functional and biocompatible intervertebral disc spacer |
US4950296A (en) * | 1988-04-07 | 1990-08-21 | Mcintyre Jonathan L | Bone grafting units |
US5015255A (en) * | 1989-05-10 | 1991-05-14 | Spine-Tech, Inc. | Spinal stabilization method |
US5071437A (en) * | 1989-02-15 | 1991-12-10 | Acromed Corporation | Artificial disc |
US5123926A (en) * | 1991-02-22 | 1992-06-23 | Madhavan Pisharodi | Artificial spinal prosthesis |
US5192327A (en) * | 1991-03-22 | 1993-03-09 | Brantigan John W | Surgical prosthetic implant for vertebrae |
US5306309A (en) * | 1992-05-04 | 1994-04-26 | Calcitek, Inc. | Spinal disk implant and implantation kit |
US5306308A (en) * | 1989-10-23 | 1994-04-26 | Ulrich Gross | Intervertebral implant |
US5338772A (en) * | 1991-06-20 | 1994-08-16 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Implant material |
US5397364A (en) * | 1993-10-12 | 1995-03-14 | Danek Medical, Inc. | Anterior interbody fusion device |
US5425772A (en) * | 1993-09-20 | 1995-06-20 | Brantigan; John W. | Prosthetic implant for intervertebral spinal fusion |
US5443514A (en) * | 1993-10-01 | 1995-08-22 | Acromed Corporation | Method for using spinal implants |
US5458638A (en) * | 1989-07-06 | 1995-10-17 | Spine-Tech, Inc. | Non-threaded spinal implant |
US5484437A (en) * | 1988-06-13 | 1996-01-16 | Michelson; Gary K. | Apparatus and method of inserting spinal implants |
US5607424A (en) * | 1995-04-10 | 1997-03-04 | Tropiano; Patrick | Domed cage |
US5669909A (en) * | 1995-03-27 | 1997-09-23 | Danek Medical, Inc. | Interbody fusion device and method for restoration of normal spinal anatomy |
US5702449A (en) * | 1995-06-07 | 1997-12-30 | Danek Medical, Inc. | Reinforced porous spinal implants |
US5766252A (en) * | 1995-01-24 | 1998-06-16 | Osteonics Corp. | Interbody spinal prosthetic implant and method |
US5814084A (en) * | 1996-01-16 | 1998-09-29 | University Of Florida Tissue Bank, Inc. | Diaphysial cortical dowel |
US5846484A (en) * | 1997-03-20 | 1998-12-08 | Osteotech, Inc. | Pressure flow system and method for treating a fluid permeable workpiece such as a bone |
US5860973A (en) * | 1995-02-27 | 1999-01-19 | Michelson; Gary Karlin | Translateral spinal implant |
US5861041A (en) * | 1997-04-07 | 1999-01-19 | Arthit Sitiso | Intervertebral disk prosthesis and method of making the same |
US5865845A (en) * | 1996-03-05 | 1999-02-02 | Thalgott; John S. | Prosthetic intervertebral disc |
US5868749A (en) * | 1996-04-05 | 1999-02-09 | Reed; Thomas M. | Fixation devices |
US5888227A (en) * | 1995-10-20 | 1999-03-30 | Synthes (U.S.A.) | Inter-vertebral implant |
US5898749A (en) * | 1996-02-02 | 1999-04-27 | Vattenfall Ab | Steam blowing assembly for nuclear power plants |
US5899939A (en) * | 1998-01-21 | 1999-05-04 | Osteotech, Inc. | Bone-derived implant for load-supporting applications |
US5972368A (en) * | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
US5989289A (en) * | 1995-10-16 | 1999-11-23 | Sdgi Holdings, Inc. | Bone grafts |
US6033438A (en) * | 1997-06-03 | 2000-03-07 | Sdgi Holdings, Inc. | Open intervertebral spacer |
US6080155A (en) * | 1988-06-13 | 2000-06-27 | Michelson; Gary Karlin | Method of inserting and preloading spinal implants |
US6159214A (en) * | 1996-07-31 | 2000-12-12 | Michelson; Gary K. | Milling instrumentation and method for preparing a space between adjacent vertebral bodies |
US6224607B1 (en) * | 1999-01-25 | 2001-05-01 | Gary K. Michelson | Instrumentation and method for creating an intervertebral space for receiving an implant |
US6231610B1 (en) * | 1999-08-25 | 2001-05-15 | Allegiance Corporation | Anterior cervical column support device |
US6241770B1 (en) * | 1999-03-05 | 2001-06-05 | Gary K. Michelson | Interbody spinal fusion implant having an anatomically conformed trailing end |
US6241771B1 (en) * | 1997-08-13 | 2001-06-05 | Cambridge Scientific, Inc. | Resorbable interbody spinal fusion devices |
US6245108B1 (en) * | 1999-02-25 | 2001-06-12 | Spineco | Spinal fusion implant |
US6258125B1 (en) * | 1998-08-03 | 2001-07-10 | Synthes (U.S.A.) | Intervertebral allograft spacer |
US6277149B1 (en) * | 1999-06-08 | 2001-08-21 | Osteotech, Inc. | Ramp-shaped intervertebral implant |
US6294187B1 (en) * | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
US20010034553A1 (en) * | 2000-02-04 | 2001-10-25 | Michelson Gary Karlin | Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion |
US6350283B1 (en) * | 2000-04-19 | 2002-02-26 | Gary K. Michelson | Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof |
US20020029081A1 (en) * | 1999-01-22 | 2002-03-07 | Scarborough Nelson L. | Method for forming an intervertebral implant |
US6371988B1 (en) * | 1996-10-23 | 2002-04-16 | Sdgi Holdings, Inc. | Bone grafts |
US6410519B1 (en) * | 1999-03-04 | 2002-06-25 | United States Surgical Corporation | Scar reduction |
US6423095B1 (en) * | 1995-10-16 | 2002-07-23 | Sdgi Holdings, Inc. | Intervertebral spacers |
US6428576B1 (en) * | 1999-04-16 | 2002-08-06 | Endospine, Ltd. | System for repairing inter-vertebral discs |
US20020111680A1 (en) * | 2000-06-13 | 2002-08-15 | Michelson Gary K. | Ratcheted bone dowel |
US6471724B2 (en) * | 1995-03-27 | 2002-10-29 | Sdgi Holdings, Inc. | Methods and instruments for interbody fusion |
US20020161442A1 (en) * | 2001-04-02 | 2002-10-31 | Michelson Gary K. | Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite |
US6511509B1 (en) * | 1997-10-20 | 2003-01-28 | Lifenet | Textured bone allograft, method of making and using same |
US6562072B1 (en) * | 1998-01-23 | 2003-05-13 | Aesculap Ag & Co. Kg | Implant for insertion between spinal column vertebrae |
US20030130737A1 (en) * | 2000-02-22 | 2003-07-10 | Mcgahan Thomas V. | Anterior impacted bone graft and driver instruments |
US6610065B1 (en) * | 1998-10-28 | 2003-08-26 | Sdgi Holdings, Inc. | Interbody fusion implants and instrumentation |
US6666888B1 (en) * | 2000-08-23 | 2003-12-23 | Roger P. Jackson | Threaded fusion cage with enhanced anterior support |
US6689167B2 (en) * | 1998-10-27 | 2004-02-10 | George W. Bagby | Method of using spinal fusion device, bone joining implant, and vertebral fusion implant |
US6706067B2 (en) * | 2000-11-03 | 2004-03-16 | Osteotech, Inc. | Spinal intervertebral implant and method of making |
US6749636B2 (en) * | 2001-04-02 | 2004-06-15 | Gary K. Michelson | Contoured spinal fusion implants made of bone or a bone composite material |
US6827740B1 (en) * | 1999-12-08 | 2004-12-07 | Gary K. Michelson | Spinal implant surface configuration |
US6902581B2 (en) * | 2000-10-24 | 2005-06-07 | Kowmedica Osteonics Corp. | Apparatus for fusing adjacent bone structure |
US20050171607A1 (en) * | 2000-06-13 | 2005-08-04 | Michelson Gary K. | Manufactured bone composite implant shaped to conform to a prepared implantation space |
US6989289B1 (en) * | 1998-05-22 | 2006-01-24 | Matsushita Electric Industrial Co., Ltd. | Electrolytic capacitor and method of producing the same |
US7094239B1 (en) * | 1999-05-05 | 2006-08-22 | Sdgi Holdings, Inc. | Screws of cortical bone and method of manufacture thereof |
US7156875B2 (en) * | 2000-04-19 | 2007-01-02 | Warsaw Orthopedic, Inc. | Arcuate artificial hemi-lumbar interbody spinal fusion implant having an asymmetrical leading end |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD245259S (en) | 1976-01-29 | 1977-08-02 | Zimmer U.S.A. Inc. | Tibial prosthesis |
EP0077159A1 (en) | 1981-10-14 | 1983-04-20 | Brian Norman Atkins | Vertebrae spreader |
FR2570594B1 (en) | 1984-09-26 | 1989-02-24 | Kehr Pierre | VERTEBRAL PROSTHESIS, PARTICULARLY FOR CERVICAL VERTEBRES |
ES283078Y (en) | 1984-11-30 | 1985-12-16 | Otero Vich Jose M. | BONE INSERT FOR CERVICAL INTERSOMATIC ARTHRODESIS |
DE4215137A1 (en) | 1991-06-04 | 1992-12-10 | Man Ceramics Gmbh | IMPLANT FOR SPINE PILLARS |
DE9216092U1 (en) | 1992-11-26 | 1993-01-14 | S + G Implants Gmbh, 2400 Luebeck, De | |
US5856845A (en) * | 1993-01-28 | 1999-01-05 | Sanyo Electric Co., Ltd. | Imaging device for recording and reproducing slow motion pictures |
FR2703580B1 (en) | 1993-03-03 | 1997-10-17 | Gilles Robert | Cervical interbody fusion cage. |
DE4318700C1 (en) | 1993-06-04 | 1994-11-17 | S & G Implants Gmbh | Implant to stiffen neighboring vertebrae |
US7043263B2 (en) * | 2002-04-11 | 2006-05-09 | Kyocera Wireless Corp. | System and method for mobile configuration |
US20060171606A1 (en) * | 2002-11-01 | 2006-08-03 | Dean Valentine | Methods and apparatus for a readily opened and closed, roll up container |
-
2001
- 2001-06-11 AU AU2001274821A patent/AU2001274821A1/en not_active Abandoned
- 2001-06-11 WO PCT/US2001/014844 patent/WO2001095837A1/en active Application Filing
-
2005
- 2005-03-24 US US11/089,086 patent/US20050171606A1/en not_active Abandoned
- 2005-03-24 US US11/089,087 patent/US8105383B2/en not_active Expired - Fee Related
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US245259A (en) * | 1881-08-02 | crompton | ||
US3867728A (en) * | 1971-12-30 | 1975-02-25 | Cutter Lab | Prosthesis for spinal repair |
US4070514A (en) * | 1973-06-05 | 1978-01-24 | The United States Of America As Represented By The United States Department Of Energy | Method of fabricating graphite for use as a skeletal prosthesis and product thereof |
US4349921A (en) * | 1980-06-13 | 1982-09-21 | Kuntz J David | Intervertebral disc prosthesis |
US4309777A (en) * | 1980-11-13 | 1982-01-12 | Patil Arun A | Artificial intervertebral disc |
US4877020A (en) * | 1984-11-30 | 1989-10-31 | Vich Jose M O | Apparatus for bone graft |
US4599086A (en) * | 1985-06-07 | 1986-07-08 | Doty James R | Spine stabilization device and method |
US4743256A (en) * | 1985-10-04 | 1988-05-10 | Brantigan John W | Surgical prosthetic implant facilitating vertebral interbody fusion and method |
US4834757A (en) * | 1987-01-22 | 1989-05-30 | Brantigan John W | Prosthetic implant |
US4878915A (en) * | 1987-01-22 | 1989-11-07 | Brantigan John W | Surgical prosthetic implant facilitating vertebral interbody fusion |
US4714469A (en) * | 1987-02-26 | 1987-12-22 | Pfizer Hospital Products Group, Inc. | Spinal implant |
US4863477A (en) * | 1987-05-12 | 1989-09-05 | Monson Gary L | Synthetic intervertebral disc prosthesis |
US4904261A (en) * | 1987-08-06 | 1990-02-27 | A. W. Showell (Surgicraft) Limited | Spinal implants |
US4950296A (en) * | 1988-04-07 | 1990-08-21 | Mcintyre Jonathan L | Bone grafting units |
US4911718A (en) * | 1988-06-10 | 1990-03-27 | University Of Medicine & Dentistry Of N.J. | Functional and biocompatible intervertebral disc spacer |
US6080155A (en) * | 1988-06-13 | 2000-06-27 | Michelson; Gary Karlin | Method of inserting and preloading spinal implants |
US5484437A (en) * | 1988-06-13 | 1996-01-16 | Michelson; Gary K. | Apparatus and method of inserting spinal implants |
US5071437A (en) * | 1989-02-15 | 1991-12-10 | Acromed Corporation | Artificial disc |
US5015255A (en) * | 1989-05-10 | 1991-05-14 | Spine-Tech, Inc. | Spinal stabilization method |
US5062845A (en) * | 1989-05-10 | 1991-11-05 | Spine-Tech, Inc. | Method of making an intervertebral reamer |
US5458638A (en) * | 1989-07-06 | 1995-10-17 | Spine-Tech, Inc. | Non-threaded spinal implant |
US5306308A (en) * | 1989-10-23 | 1994-04-26 | Ulrich Gross | Intervertebral implant |
US5123926A (en) * | 1991-02-22 | 1992-06-23 | Madhavan Pisharodi | Artificial spinal prosthesis |
US5192327A (en) * | 1991-03-22 | 1993-03-09 | Brantigan John W | Surgical prosthetic implant for vertebrae |
US5338772A (en) * | 1991-06-20 | 1994-08-16 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Implant material |
US5306309A (en) * | 1992-05-04 | 1994-04-26 | Calcitek, Inc. | Spinal disk implant and implantation kit |
US5425772A (en) * | 1993-09-20 | 1995-06-20 | Brantigan; John W. | Prosthetic implant for intervertebral spinal fusion |
US5443514A (en) * | 1993-10-01 | 1995-08-22 | Acromed Corporation | Method for using spinal implants |
US5397364A (en) * | 1993-10-12 | 1995-03-14 | Danek Medical, Inc. | Anterior interbody fusion device |
US5766252A (en) * | 1995-01-24 | 1998-06-16 | Osteonics Corp. | Interbody spinal prosthetic implant and method |
US5860973A (en) * | 1995-02-27 | 1999-01-19 | Michelson; Gary Karlin | Translateral spinal implant |
US6471724B2 (en) * | 1995-03-27 | 2002-10-29 | Sdgi Holdings, Inc. | Methods and instruments for interbody fusion |
US5669909A (en) * | 1995-03-27 | 1997-09-23 | Danek Medical, Inc. | Interbody fusion device and method for restoration of normal spinal anatomy |
US6645206B1 (en) * | 1995-03-27 | 2003-11-11 | Sdgi Holdings, Inc. | Interbody fusion device and method for restoration of normal spinal anatomy |
US5607424A (en) * | 1995-04-10 | 1997-03-04 | Tropiano; Patrick | Domed cage |
US5702449A (en) * | 1995-06-07 | 1997-12-30 | Danek Medical, Inc. | Reinforced porous spinal implants |
US20050004672A1 (en) * | 1995-10-16 | 2005-01-06 | John Pafford | Bone grafts |
US5989289A (en) * | 1995-10-16 | 1999-11-23 | Sdgi Holdings, Inc. | Bone grafts |
US6423095B1 (en) * | 1995-10-16 | 2002-07-23 | Sdgi Holdings, Inc. | Intervertebral spacers |
US5888227A (en) * | 1995-10-20 | 1999-03-30 | Synthes (U.S.A.) | Inter-vertebral implant |
US5814084A (en) * | 1996-01-16 | 1998-09-29 | University Of Florida Tissue Bank, Inc. | Diaphysial cortical dowel |
US5898749A (en) * | 1996-02-02 | 1999-04-27 | Vattenfall Ab | Steam blowing assembly for nuclear power plants |
US5865845A (en) * | 1996-03-05 | 1999-02-02 | Thalgott; John S. | Prosthetic intervertebral disc |
US5868749A (en) * | 1996-04-05 | 1999-02-09 | Reed; Thomas M. | Fixation devices |
US20040249388A1 (en) * | 1996-07-31 | 2004-12-09 | Michelson Gary K. | Distractor with opening |
US20040215203A1 (en) * | 1996-07-31 | 2004-10-28 | Michelson Gary K. | Bone removal device |
US6159214A (en) * | 1996-07-31 | 2000-12-12 | Michelson; Gary K. | Milling instrumentation and method for preparing a space between adjacent vertebral bodies |
US6371988B1 (en) * | 1996-10-23 | 2002-04-16 | Sdgi Holdings, Inc. | Bone grafts |
US5846484A (en) * | 1997-03-20 | 1998-12-08 | Osteotech, Inc. | Pressure flow system and method for treating a fluid permeable workpiece such as a bone |
US5861041A (en) * | 1997-04-07 | 1999-01-19 | Arthit Sitiso | Intervertebral disk prosthesis and method of making the same |
US6033438A (en) * | 1997-06-03 | 2000-03-07 | Sdgi Holdings, Inc. | Open intervertebral spacer |
US5972368A (en) * | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
US7077866B2 (en) * | 1997-08-13 | 2006-07-18 | Depuy Mitek, Inc. | Resorbable interbody spinal fusion devices |
US6241771B1 (en) * | 1997-08-13 | 2001-06-05 | Cambridge Scientific, Inc. | Resorbable interbody spinal fusion devices |
US6511509B1 (en) * | 1997-10-20 | 2003-01-28 | Lifenet | Textured bone allograft, method of making and using same |
US5899939A (en) * | 1998-01-21 | 1999-05-04 | Osteotech, Inc. | Bone-derived implant for load-supporting applications |
US6562072B1 (en) * | 1998-01-23 | 2003-05-13 | Aesculap Ag & Co. Kg | Implant for insertion between spinal column vertebrae |
US20050256574A1 (en) * | 1998-01-30 | 2005-11-17 | Paul David C | Intervertebral allograft spacer |
US6989289B1 (en) * | 1998-05-22 | 2006-01-24 | Matsushita Electric Industrial Co., Ltd. | Electrolytic capacitor and method of producing the same |
US6258125B1 (en) * | 1998-08-03 | 2001-07-10 | Synthes (U.S.A.) | Intervertebral allograft spacer |
US6689167B2 (en) * | 1998-10-27 | 2004-02-10 | George W. Bagby | Method of using spinal fusion device, bone joining implant, and vertebral fusion implant |
US6610065B1 (en) * | 1998-10-28 | 2003-08-26 | Sdgi Holdings, Inc. | Interbody fusion implants and instrumentation |
US6383221B1 (en) * | 1999-01-22 | 2002-05-07 | Osteotech, Inc. | Method for forming an intervertebral implant |
US20020029081A1 (en) * | 1999-01-22 | 2002-03-07 | Scarborough Nelson L. | Method for forming an intervertebral implant |
US6224607B1 (en) * | 1999-01-25 | 2001-05-01 | Gary K. Michelson | Instrumentation and method for creating an intervertebral space for receiving an implant |
US20030195517A1 (en) * | 1999-01-25 | 2003-10-16 | Michelson Gary K. | Instrumentation for creating an intervertebral space for receiving an implant |
US6294187B1 (en) * | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
US6245108B1 (en) * | 1999-02-25 | 2001-06-12 | Spineco | Spinal fusion implant |
US6410519B1 (en) * | 1999-03-04 | 2002-06-25 | United States Surgical Corporation | Scar reduction |
US6241770B1 (en) * | 1999-03-05 | 2001-06-05 | Gary K. Michelson | Interbody spinal fusion implant having an anatomically conformed trailing end |
US6428576B1 (en) * | 1999-04-16 | 2002-08-06 | Endospine, Ltd. | System for repairing inter-vertebral discs |
US7094239B1 (en) * | 1999-05-05 | 2006-08-22 | Sdgi Holdings, Inc. | Screws of cortical bone and method of manufacture thereof |
US6277149B1 (en) * | 1999-06-08 | 2001-08-21 | Osteotech, Inc. | Ramp-shaped intervertebral implant |
US6231610B1 (en) * | 1999-08-25 | 2001-05-15 | Allegiance Corporation | Anterior cervical column support device |
US6827740B1 (en) * | 1999-12-08 | 2004-12-07 | Gary K. Michelson | Spinal implant surface configuration |
US20010034553A1 (en) * | 2000-02-04 | 2001-10-25 | Michelson Gary Karlin | Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion |
US6709458B2 (en) * | 2000-02-04 | 2004-03-23 | Gary Karlin Michelson | Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion |
US20030130737A1 (en) * | 2000-02-22 | 2003-07-10 | Mcgahan Thomas V. | Anterior impacted bone graft and driver instruments |
US6666890B2 (en) * | 2000-04-19 | 2003-12-23 | Gary K. Michelson | Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof |
US7022137B2 (en) * | 2000-04-19 | 2006-04-04 | Sdgi Holdings, Inc. | Bone hemi-lumbar interbody spinal fusion implant having an asymmetrical leading end and method of installation thereof |
US7462195B1 (en) * | 2000-04-19 | 2008-12-09 | Warsaw Orthopedic, Inc. | Artificial lumbar interbody spinal implant having an asymmetrical leading end |
US6350283B1 (en) * | 2000-04-19 | 2002-02-26 | Gary K. Michelson | Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof |
US7387643B2 (en) * | 2000-04-19 | 2008-06-17 | Warsaw Orthopedic, Inc. | Method for installation of artificial hemi-lumbar interbody spinal fusion implant having an asymmetrical leading end |
US7156875B2 (en) * | 2000-04-19 | 2007-01-02 | Warsaw Orthopedic, Inc. | Arcuate artificial hemi-lumbar interbody spinal fusion implant having an asymmetrical leading end |
US20060235519A1 (en) * | 2000-04-19 | 2006-10-19 | Sdgi Holdings, Inc. | Bone hemi-lumbar arcuate interbody spinal fusion implant having an asymmetrical leading end |
US20020111680A1 (en) * | 2000-06-13 | 2002-08-15 | Michelson Gary K. | Ratcheted bone dowel |
US20050171607A1 (en) * | 2000-06-13 | 2005-08-04 | Michelson Gary K. | Manufactured bone composite implant shaped to conform to a prepared implantation space |
US20050267578A1 (en) * | 2000-06-13 | 2005-12-01 | Michelson Gary K | Ratcheted bone dowel having smooth sides and method for use thereof |
US6666888B1 (en) * | 2000-08-23 | 2003-12-23 | Roger P. Jackson | Threaded fusion cage with enhanced anterior support |
US6902581B2 (en) * | 2000-10-24 | 2005-06-07 | Kowmedica Osteonics Corp. | Apparatus for fusing adjacent bone structure |
US6706067B2 (en) * | 2000-11-03 | 2004-03-16 | Osteotech, Inc. | Spinal intervertebral implant and method of making |
US20040230308A1 (en) * | 2001-04-02 | 2004-11-18 | Michelson Gary K. | Contoured cortical bone implants |
US6989031B2 (en) * | 2001-04-02 | 2006-01-24 | Sdgi Holdings, Inc. | Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite |
US6749636B2 (en) * | 2001-04-02 | 2004-06-15 | Gary K. Michelson | Contoured spinal fusion implants made of bone or a bone composite material |
US20060122702A1 (en) * | 2001-04-02 | 2006-06-08 | Michelson Gary K | Hemi-interbody spinal fusion implants manufactured from a major long bone ring |
US7435262B2 (en) * | 2001-04-02 | 2008-10-14 | Warsaw Orthopedic, Inc. | Contoured cortical bone implants |
US20020161442A1 (en) * | 2001-04-02 | 2002-10-31 | Michelson Gary K. | Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite |
US7611536B2 (en) * | 2001-04-02 | 2009-11-03 | Warsaw Orthopedic, Inc. | Hemi-interbody spinal fusion implants manufactured from a major long bone ring |
US20100030333A1 (en) * | 2001-04-02 | 2010-02-04 | Michelson Gary K | Hemi-interbody spinal fusion implants manufactured from a major long bone ring |
Cited By (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050267578A1 (en) * | 2000-06-13 | 2005-12-01 | Michelson Gary K | Ratcheted bone dowel having smooth sides and method for use thereof |
US20050171607A1 (en) * | 2000-06-13 | 2005-08-04 | Michelson Gary K. | Manufactured bone composite implant shaped to conform to a prepared implantation space |
US8105383B2 (en) | 2000-06-13 | 2012-01-31 | Warsaw Orthopedic, Inc. | Manufactured bone composite implant shaped to conform to a prepared implantation space |
US10492922B2 (en) | 2002-02-19 | 2019-12-03 | DePuy Synthes Products, Inc. | Intervertebral implant |
US10064740B2 (en) | 2003-02-06 | 2018-09-04 | DePuy Synthes Products, LLC | Intervertebral implant |
US10660765B2 (en) | 2003-02-06 | 2020-05-26 | DePuy Synthes Products, Inc. | Intervertebral implant |
US7736380B2 (en) | 2004-12-21 | 2010-06-15 | Rhausler, Inc. | Cervical plate system |
US20090299412A1 (en) * | 2006-02-02 | 2009-12-03 | Trinity Orthopedics | Percutaneous facet joint fusion system and method |
US11696837B2 (en) | 2006-02-27 | 2023-07-11 | DePuy Synthes Products, Inc. | Intervertebral implant with fixation geometry |
US10512548B2 (en) | 2006-02-27 | 2019-12-24 | DePuy Synthes Products, Inc. | Intervertebral implant with fixation geometry |
US8192492B2 (en) | 2007-02-19 | 2012-06-05 | Zimmer Spine, Inc. | Spinal implant |
US20080200985A1 (en) * | 2007-02-19 | 2008-08-21 | Zimmer Spine, Inc. | Spinal implant |
US8568484B2 (en) | 2007-02-19 | 2013-10-29 | Zimmer Spine, Inc. | Spinal implant |
US20080208342A1 (en) * | 2007-02-27 | 2008-08-28 | Zimmer Spine, Inc. | Spinal implant |
US10543102B2 (en) | 2007-11-16 | 2020-01-28 | DePuy Synthes Products, Inc. | Low profile intervertebral implant |
US9744049B2 (en) | 2007-11-16 | 2017-08-29 | DePuy Synthes Products, Inc. | Low profile intervertebral implant |
US8540774B2 (en) | 2007-11-16 | 2013-09-24 | DePuy Synthes Products, LLC | Low profile intervertebral implant |
US9005295B2 (en) | 2007-11-16 | 2015-04-14 | DePuy Synthes Products, LLC | Low profile intervertebral implant |
US10137003B2 (en) | 2007-11-16 | 2018-11-27 | DePuy Synthes Products, Inc. | Low profile intervertebral implant |
US20120277862A1 (en) * | 2008-04-04 | 2012-11-01 | Clariance | Nuclear implant |
US8652209B2 (en) * | 2008-04-04 | 2014-02-18 | Clariance | Nuclear implant |
US11612492B2 (en) | 2008-11-07 | 2023-03-28 | DePuy Synthes Products, Inc. | Zero-profile interbody spacer and coupled plate assembly |
US11517444B2 (en) | 2008-11-07 | 2022-12-06 | DePuy Synthes Products, Inc. | Zero-profile interbody spacer and coupled plate assembly |
US10531960B2 (en) | 2008-11-07 | 2020-01-14 | DePuy Synthes Products, Inc. | Zero-profile interbody spacer and coupled plate assembly |
US10433976B2 (en) | 2008-11-07 | 2019-10-08 | DePuy Synthes Products, Inc. | Zero-profile interbody spacer and coupled plate assembly |
US8828082B2 (en) | 2009-07-09 | 2014-09-09 | R Tree Innovations, Llc | Inter-body implant |
US10835386B2 (en) | 2009-07-09 | 2020-11-17 | R Tree Innovations, Llc | Inter-body implantation system and method |
US10806594B2 (en) | 2009-07-09 | 2020-10-20 | R Tree Innovations, Llc | Inter-body implant |
US9814599B2 (en) | 2009-07-09 | 2017-11-14 | R Tree Innovations, Llc | Inter-body implantation system and method |
US9877844B2 (en) | 2009-07-09 | 2018-01-30 | R Tree Innovations, Llc | Inter-body implant |
US9730804B2 (en) | 2009-09-06 | 2017-08-15 | Warsaw Orthopedic, Inc. | Locking spinal fusion device |
US9480511B2 (en) | 2009-12-17 | 2016-11-01 | Engage Medical Holdings, Llc | Blade fixation for ankle fusion and arthroplasty |
US10238426B2 (en) | 2009-12-17 | 2019-03-26 | Engage Medical Holdings, Llc | Blade fixation for ankle fusion and arthroplasty |
US8480747B2 (en) | 2010-08-11 | 2013-07-09 | Warsaw Orthopedic, Inc. | Interbody spinal implants with extravertebral support plates |
US8845737B2 (en) | 2010-08-11 | 2014-09-30 | Warsaw Orthopedic, Inc. | Interbody spinal implants with extravertebral support plates |
US9925051B2 (en) | 2010-12-16 | 2018-03-27 | Engage Medical Holdings, Llc | Arthroplasty systems and methods |
US10342667B2 (en) | 2010-12-16 | 2019-07-09 | Engage Medical Holdings, Llc | Arthroplasty systems and methods |
US11197763B2 (en) | 2010-12-16 | 2021-12-14 | Engage Medical Holdings, Llc | Arthroplasty systems and methods |
US10507117B2 (en) | 2010-12-21 | 2019-12-17 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US9848992B2 (en) | 2010-12-21 | 2017-12-26 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US11458027B2 (en) | 2010-12-21 | 2022-10-04 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US9180019B2 (en) | 2011-03-03 | 2015-11-10 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US9526532B2 (en) | 2011-03-03 | 2016-12-27 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US8454694B2 (en) | 2011-03-03 | 2013-06-04 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US8690948B2 (en) | 2011-03-03 | 2014-04-08 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US9925063B2 (en) | 2011-03-03 | 2018-03-27 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US9615940B2 (en) | 2011-03-03 | 2017-04-11 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US10245090B2 (en) | 2011-11-01 | 2019-04-02 | Engage Medical Holdings, Llc | Blade anchor systems for bone fusion |
US9254130B2 (en) | 2011-11-01 | 2016-02-09 | Hyun Bae | Blade anchor systems for bone fusion |
US10238382B2 (en) | 2012-03-26 | 2019-03-26 | Engage Medical Holdings, Llc | Blade anchor for foot and ankle |
US9867718B2 (en) | 2014-10-22 | 2018-01-16 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US10702394B2 (en) | 2014-10-22 | 2020-07-07 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US11540927B2 (en) | 2014-10-22 | 2023-01-03 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US10010432B2 (en) | 2014-10-22 | 2018-07-03 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US10130492B2 (en) | 2014-10-22 | 2018-11-20 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
US10390955B2 (en) | 2016-09-22 | 2019-08-27 | Engage Medical Holdings, Llc | Bone implants |
US11369488B2 (en) | 2017-03-03 | 2022-06-28 | Engage Uni Llc | Unicompartmental knee arthroplasty |
US10456272B2 (en) | 2017-03-03 | 2019-10-29 | Engage Uni Llc | Unicompartmental knee arthroplasty |
US11540928B2 (en) | 2017-03-03 | 2023-01-03 | Engage Uni Llc | Unicompartmental knee arthroplasty |
Also Published As
Publication number | Publication date |
---|---|
AU2001274821A1 (en) | 2001-12-24 |
US8105383B2 (en) | 2012-01-31 |
WO2001095837A1 (en) | 2001-12-20 |
US20050171607A1 (en) | 2005-08-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8105383B2 (en) | Manufactured bone composite implant shaped to conform to a prepared implantation space | |
US8137403B2 (en) | Hemi-interbody spinal fusion implants manufactured from a major long bone ring | |
US6666890B2 (en) | Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof | |
US6749636B2 (en) | Contoured spinal fusion implants made of bone or a bone composite material | |
US6511509B1 (en) | Textured bone allograft, method of making and using same | |
US7323011B2 (en) | Cortical and cancellous allograft cervical fusion block | |
US8182532B2 (en) | Composite bone graft, method of making and using same | |
US6761739B2 (en) | Cortical and cancellous allograft spacer | |
US7163560B2 (en) | Method for graftless spinal fusion | |
US8834569B2 (en) | Artificial hemi-lumbar interbody spinal fusion cage having an asymmetrical leading end | |
US7621960B2 (en) | Modular interbody fusion implant | |
US6383221B1 (en) | Method for forming an intervertebral implant | |
US4865604A (en) | Prosthetic bone joint | |
US20030167092A1 (en) | Spinal bone implant | |
US20050010304A1 (en) | Device and method for reconstruction of osseous skeletal defects | |
WO2001080784A1 (en) | Hemi-lumbar interbody spinal implant having an asymmetrical leading end and method for installation thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: SDGI HOLDINGS, INC.,DELAWARE Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MICHELSON, GARY KARLIN;KARLIN TECHNOLOGY, INC.;REEL/FRAME:016195/0282 Effective date: 20050517 Owner name: SDGI HOLDINGS, INC., DELAWARE Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MICHELSON, GARY KARLIN;KARLIN TECHNOLOGY, INC.;REEL/FRAME:016195/0282 Effective date: 20050517 |
|
AS | Assignment |
Owner name: WARSAW ORTHOPEDIC, INC., INDIANA Free format text: MERGER;ASSIGNOR:SDGI HOLDINGS, INC.;REEL/FRAME:018552/0456 Effective date: 20060428 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |