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Publication numberUS20050171606 A1
Publication typeApplication
Application numberUS 11/089,086
Publication date4 Aug 2005
Filing date24 Mar 2005
Priority date13 Jun 2000
Also published asUS8105383, US20050171607, WO2001095837A1
Publication number089086, 11089086, US 2005/0171606 A1, US 2005/171606 A1, US 20050171606 A1, US 20050171606A1, US 2005171606 A1, US 2005171606A1, US-A1-20050171606, US-A1-2005171606, US2005/0171606A1, US2005/171606A1, US20050171606 A1, US20050171606A1, US2005171606 A1, US2005171606A1
InventorsGary Michelson
Original AssigneeMichelson Gary K.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Method for installation of manufactured implants shaped to conform to a prepared implantation space
US 20050171606 A1
Abstract
The present invention is directed to a major long bone ring implant for insertion into an implantation space formed across a spinal disc between two adjacent vertebral bodies of the spine. The implantation space has a wall portion, lip, or ridge with a flat portion for abutting the leading end of the bone ring implant. The bone ring implant has a leading end and a trailing end connected by opposed sides. The leading end has a straight cut portion. The opposed sides have portions that are preferably straight and at a 90 angle to the straight cut portion of the leading end to produce straight portions that are outwardly facing. The bone ring implant may be machined from a single bone or manufactured from a composite of cortical fibers, filaments, or particles. The bone ring implant may be used in combination with lockable screws, and preferably screw locks each preferably made of cortical bone or of a bioresorbable material.
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Claims(18)
1. A method for performing a spinal surgery across the height of a disc space between two adjacent vertebral bodies of a human spine, the method comprising the steps of:
removing bone from each of the adjacent vertebral bodies with a bone cutting device to form an implantation space having a front wall and opposite side walls, said front wall having a generally flat portion; and
inserting a spinal implant into the implantation space, the spinal implant being formed from a bone ring obtained from a major long bone of a human, the implant having a generally straight leading end from side to side adapted to abut the generally flat portion of the front wall of the implantation space and opposite sides adapted to abut the side walls of the implantation space, respectively.
2. The method of claim 1, wherein the inserting step includes the step of inserting a spinal implant in combination with fusion promoting substances.
3. The method of claim 1, wherein the inserting step includes the step of inserting a spinal implant in combination with a fusion promoting material other than bone.
4. The method of claim 1, wherein the inserting step includes the step of inserting a spinal implant in combination with bone morphogenetic protein.
5. The method of claim 1, wherein the inserting step includes the step of inserting a spinal implant in combination with an osteogenic material.
6. The method of claim 5, wherein said osteogenic material is a material other than bone.
7. The method of claim 5, wherein said osteogenic material is genetic material coding for production of bone.
8. The method of claim 1, wherein the inserting step includes the step of inserting a spinal implant in combination with genetic material coding for production of bone.
9. The method of claim 1, wherein the inserting step includes the step of inserting a spinal implant in combination with a chemical substance to inhibit scar formation.
10. A method for performing a spinal surgery across the height of a disc space between two adjacent vertebral bodies of a human spine, the method comprising the steps of:
removing bone from each of the adjacent vertebral bodies with a bone cutting device to form an implantation space having a front wall and opposite side walls, said front wall having a generally flat portion; and
inserting a spinal implant into the implantation space, the spinal implant being formed of a bone composite material, the implant having a generally straight leading end from side to side adapted to abut the generally flat portion of the front wall of the implantation space and opposite sides adapted to abut the side walls of the implantation space, respectively.
11. The method of claim 10, wherein the inserting step includes the step of inserting a spinal implant in combination with fusion promoting substances.
12. The method of claim 10, wherein the inserting step includes the step of inserting a spinal implant in combination with a fusion promoting material other than bone.
13. The method of claim 10, wherein the inserting step includes the step of inserting a spinal implant in combination with bone morphogenetic protein.
14. The method of claim 10, wherein the inserting step includes the step of inserting a spinal implant in combination with an osteogenic material.
15. The method of claim 14, wherein said osteogenic material is a material other than bone.
16. The method of claim 14, wherein said osteogenic material is genetic material coding for production of bone.
17. The method of claim 10, wherein the inserting step includes the step of inserting a spinal implant in combination with genetic material coding for production of bone.
18. The method of claim 10, wherein the inserting step includes the step of inserting a spinal implant in combination with a chemical substance to inhibit scar formation.
Description
  • [0001]
    The present application is a divisional of application Ser. No. 09/593,591, filed Jun. 13, 2000, which is incorporated herein by reference.
  • BACKGROUND OF THE INVENTION
  • [0002]
    The diaphysis is the shaft of a long bone, as distinguished from the epiphysis, the end of the bone forming the joints. When the diaphysis is cut twice, more or less transversely, a complete bone ring is formed with the medulary canal forming an opening through the ring. Such rings are generally harvested from femurs for use in the lumbar spine. Other bones from the arm or leg or other part of the skeleton may be useful in various regions of the spine.
  • [0003]
    The use of diaphyseal bone rings, such as those harvested from human femurs, is well known in the art of spinal fusion. For interbody spinal fusion, femoral rings are formed by making two spaced apart cuts approximately perpendicular to the long axis of the diaphyseal portion of a human cadaveric femur. The cuts are generally spaced apart so as to form a ring having a height corresponding to the restored disc space or slightly greater. Femoral ring bone grafts are placed into the spine within and across the height of the space previously occupied by a spinal disc between adjacent vertebral bodies to achieve interbody fusion of those vertebral bodies through the disc space. The femoral ring bone graft is incorporated into the bony fusion over time.
  • [0004]
    Interbody spinal fusion with bone rings, however, has had limited success in the past. While all the causes for failure may not yet be appreciated, it is nevertheless believed that a failure to gain congruity at the interfaces of the bone ring implant to the adjacent vertebral bodies, and a failure to achieve stability of the bone ring implant, may be two of the more significant factors subject to the surgeon's control contributing to such failures.
  • [0005]
    Bone rings that are entirely or almost entirely made of cortical bone offer the advantages of that material including an appropriate modulus of elasticity and strength for the prescribed use, the capacity to be bioactive, including being osteoconductive, osteoinductive, osteogenic, and to more generally provide a good substrate for the formation of new bone as fusion occurs. Further, by being bioabsorable the bone material is replaced by the patient's own bone over time, thereby preventing stress shielding and leading to the eventual elimination of any foreign body from the implantation site.
  • [0006]
    As it is desirable to take advantage of all these benefits, there exists a need for an improved bone ring implant, which when used in accordance with the prescribed method of disc space preparation, provides for an improved congruity of the implant to the vertebral bodies and improved implant stability.
  • SUMMARY OF THE INVENTION
  • [0007]
    The present invention is directed to a major long bone ring implant preferably, but not necessarily, an implant formed from a diaphyseal ring for insertion into an implantation space formed across a spinal disc between two adjacent vertebral bodies of the spine. The bone ring implant is preferably used in an implantation space having a wall portion, lip, or ridge with a flat portion for abutting the leading end of the bone ring implant. Such an implantation space can be formed with the instrumentation and method set forth in applicant's U.S. application Ser. No. 08/688,758, titled “Milling Instrumentation and Method for Preparing a Space Between Adjacent Vertebral Bodies”, incorporated by reference herein. It is appreciated however, that the bone ring implant of the present invention can be useful in implantation spaces formed by other techniques, such as for example, applicant's U.S. application Ser. No. 09/490,901, titled “Instrument And Method For Creating An Intervertebral Space For Receiving An Implant”, incorporated by reference herein.
  • [0008]
    The bone ring implant is manufactured and machined to have a leading end and a trailing end opposite the leading end connected by opposed sides or walls. In combination the leading end, trailing end, and the opposed sides or walls preferably form one continuous perimeter having opposed upper and lower vertebral body engaging surfaces. By way of example and not limitation, while diaphyseal rings as harvested are generally round or oval, the bone ring implants of the present invention have a substantial flat portion at the leading end formed by cutting or machining the perimeter of the bone to create a straight cut portion at the leading end. The straight cut portion is generally oriented at 90 to the mid-longitudinal axis of the bone ring implant as defined by a line passing through the center of the bone ring implant from its leading end to its trailing end.
  • [0009]
    In a preferred embodiment, the bone ring implant is further machined so that one and preferably both of the opposed sides have portions that are straight and at a 90 angle to the straight cut portion of the leading end to produce straight portions that are outwardly facing. These straight portions are generally oriented parallel to the implant's longitudinal axis. The opposed sides may be machined to be generally parallel to each other over at least a portion of the sides and may be aligned or offset from each other along the implant sides. The present invention consists of the unique machined structures of the bone ring implant, as well as may be used in combination with lockable screws, and preferably screw locks each preferably made of cortical bone or of a bioresorbable material.
  • [0010]
    The bone ring implant of the present invention may be machined so as to be adapted to receive through its trailing end at least a pair of opposed appropriately sized bone screws preferably, but not necessarily, made of cortical bone. The bone engaging screws may be aligned or offset from each other. At least one screw engages each of the vertebral bodies adjacent a disc space to be fused and into which the bone ring implant is implanted.
  • [0011]
    The bone ring implant of the present invention is preferably further machined and adapted to receive locks, preferably made of cortical bone, at the trailing end for securing the bone engaging screws therein and preventing the screws from backing out. The bone ring implant, bone screws, and/or locks can be made of a bioresorbable material, including but not limited to cortical bone, plastics and composite plastics. Suitable plastics may include those comprising lactides, galactides, glycolide, capronlactone, trimethylene carbonate, or dioxanone in various polymers, and/or combinations thereof.
  • [0012]
    The bone ring implant of the present invention can be further machined to have a specialized bone engaging surface configuration designed to enhance stability and resist motion imparted to each of the opposed upper and lower vertebrae engaging surfaces of the bone ring implant, such as for example the surface described in applicant's U.S. application Ser. No. 09/457,228 titled “Spinal Implant Surface Configuration” incorporated by reference herein.
  • [0013]
    The bone ring implant of the present invention is preferably for anterior implantation into the disc space and is preferably taller at the trailing end than at the leading end (the leading end being adapted to introduce the implant into the spine) so as to provide for a desired amount of lordosis.
  • [0014]
    The bone ring implant has been described as diaphyseal rings by way of example of one embodiment of the present invention. It should be clearly understood that such rings may be formed of bone that may be at least in part metaphyseal if sufficiently strong for the intended purpose. Alternatively, the bone ring implants may be made of a manufactured bone composite comprising of particles or filaments of bone and a bioresorbable plastic or ceramic or other suitable material without departing from the inventive concepts of the present invention, prime of which is a manufactured implant comprising cortical bone with a flat leading portion and preferably at least partial side portions that are flat and preferably 90 to the front of the implant.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0015]
    FIG. 1 is a top plan view of a vertebral body with preferably a machined implantation socket created therein for receiving a bone ring implant in accordance with the present invention.
  • [0016]
    FIG. 2A is a top plan view of a vertebral body showing the desired implantation socket with a first bone ring implant with a bone-engaging surface formed thereon and showing the machining of the bone ring required to obtain that ring's best fit to the recipient site (socket) within that vertebral body.
  • [0017]
    FIG. 2B is a top plan view of a vertebral body showing the desired implantation socket with a second bone ring implant with the bone-engaging surface formed thereon and showing the machining of the bone ring required to obtain that ring's best fit to the recipient site (socket) within that vertebral body.
  • [0018]
    FIG. 3A is an enlarged fragmentary view along line 3-3 of FIG. 2A of the bone-engaging surface.
  • [0019]
    FIG. 3B is a side view of FIG. 3A illustrating the configuration of the bone-engaging surface.
  • [0020]
    FIG. 4 is a trailing end view of a bone ring implant in accordance with an embodiment of the present invention having openings oriented toward the adjacent vertebral bodies for receiving bone-engaging screws.
  • [0021]
    FIG. 5 is a side elevation view of the bone ring implant of FIG. 4.
  • [0022]
    FIG. 6 is a leading end view of the bone ring implant of FIG. 4.
  • [0023]
    FIG. 7 is a trailing end view of a bone ring implant in accordance with a second embodiment of the present invention.
  • [0024]
    FIG. 8 is a trailing end view of a bone ring implant in accordance with a third embodiment of the present invention.
  • [0025]
    FIG. 9 is a side elevation view of the bone ring implant of FIG. 6 with two bone engaging screws installed.
  • [0026]
    FIG. 10 is a top plan view of the bone ring implant of FIG. 6 machined to have a top exit screw hole and a bottom exit screw hole shown in hidden line.
  • OBJECTS OF THE PRESENT INVENTION
  • [0027]
    It is an object of an embodiment of the present invention to provide a manufactured bone ring implant having an improved contour and conformation with critical known dimensions.
  • [0028]
    It is a further object of an embodiment of the present invention to have the bone ring implant configuration conform, where critical, to an easily and reliably producible shape of an interbody recipient site.
  • [0029]
    It is a further object of an embodiment of the present invention to have opposed upper and lower vertebral body engaging surfaces configured to enhance the stability of the bone ring implant relative to the adjacent vertebral bodies when in use.
  • [0030]
    In a preferred embodiment of the present invention, it is a further object of the present invention to provide for an improved cortical bone ring implant adapted to receive at least a pair of opposed vertebral body engaging bone screws for further stabilizing the bone ring implant, and for stabilizing the adjacent vertebrae relative to the bone ring implant and to each other.
  • [0031]
    It is a further object of an embodiment of the present invention to provide for an interbody spinal fusion implant in the form of an improved ring of diaphyseal bone from a human long bone correspondingly dimensioned for a recipient site across the height of a disc space and in contact with each of the vertebral bodies adjacent that disc space.
  • [0032]
    It is a further object of an embodiment of the present invention to provide for an improved bone ring implant adapted to receive screw locks for locking opposed vertebral body engaging bone screws to the bone ring implant to prevent them from backing out.
  • DETAILED DESCRIPTION OF THE DRAWINGS
  • [0033]
    FIG. 1 shows a top plan view of a vertebral body V with an implantation space 20 created therein for receiving an implant. Implantation socket or space 20 has a posterior wall 22 and side walls 24, 26 formed at least in part in the endplate of vertebral body V. By way of example and not limitation, implantation space 20 may be created with the apparatus and methods disclosed in applicant's U.S. application Ser. No. 08/688,758.
  • [0034]
    FIGS. 2A and 2B show top plan views of vertebral body V and first and second bone ring implants 30 and 40, respectively, placed thereon with the area of implantation space 20 identified by dotted lines. Bone rings can be made from a long bone of the human body, and preferably made from a human femur. First and second bone ring implants 30, 40 have outer perimeters that are intact and not modified from their naturally occurring state such as in a human femur. Bone ring implants 30, 40 in their natural state do not fit properly within the prepared implantation space 20 bordered by posterior wall 22 and side walls 24, 26 illustrated by the dotted lines. Bone ring implant 30 has sides that extend beyond side walls 24, 26 and a leading end 32 that extends beyond posterior wall 22 of implantation space 20 and protrudes from the posterior aspect of vertebral body V. Similarly, while bone ring implant 40 does not protrude from the posterior aspect of vertebral body V, leading end 42 extends beyond posterior wall 22 and has sides that extend beyond side walls 24, 26 of implantation space 20.
  • [0035]
    FIG. 3A shows an enlarged fragmentary view of a bone-engaging surface 50 that can be formed on bone ring implants described herein to increase the stability of the bone ring implants installed between two adjacent vertebral bodies. FIG. 3B is a side view of FIG. 3A illustrating the configuration of a preferred embodiment of bone-engaging surface 50. Bone engaging surface 50 has a forward facet 52 facing the leading end of the bone ring implant, an opposite rearward portion 54 facing the trailing end of the bone ring implant, and opposed side facets 56, 58 directed generally toward the sides of the bone ring implant. Bone engaging surface 50 preferably facilitates motion in the direction of insertion and preferably resists motion in all other directions, including the direction opposite to the direction of insertion. While the specialized bone-engaging surface 50 is preferred, in the alternative the surfaces of the bone ring can be roughened, ratcheted, knurled, or otherwise modified when it is desired to increase the resistance of the bone ring implant to motion.
  • [0036]
    FIGS. 4-10 show a bone ring implant 100 in accordance with various preferred embodiments of the present invention. Bone ring implant 100 has a leading end 102 for insertion into the implantation space, an opposite trailing end 104, opposed upper and lower surfaces 106, 108, and opposed sides, 110, 112 therebetween. Upper and lower surfaces 106, 108 include a medulary canal 114 passing therethrough which may be useful to permit for the growth of bone from adjacent vertebral body to adjacent vertebral body through the medulary canal 114 in bone ring implant 100, which can to that end be filled with fusion promoting substances. Upper and lower surfaces 106, 108 may also be porous or include a bone ingrowth surface.
  • [0037]
    In a preferred embodiment of the present invention, leading end 102 and opposed sides 110, 112 are machined to configure bone ring implant 100 to conform to the shape of prepared implantation space 20. Leading end 102 and sides 110, 112 can be machined to have a more planar configuration to abut posterior wall 22 and side walls 24, 26, respectively, of implantation space 20. In this embodiment, the machined surfaces of leading end 102 and opposed sides 110, 112 are separated by the natural contour of the bone ring. For example, in a preferred embodiment, the bone ring implant 100 can be machined so either or both of sides 110, 112 are at a 90 angle to the straight cut portion of leading end 102 to produce straight portions outwardly facing and generally parallel to each other, that can be aligned or offset from each other along sides 110, 112.
  • [0038]
    Alternatively, in another embodiment of the present invention, instead of being machined from a single bone, the bone ring implant can be manufactured from a composite of cortical fibers, filaments, particles, and a material which may or may not be bioactive and/or bioresorbable such as a plastic, ceramic, for example. Once formed, the composite implant material may be machined or molded, into the desired shape.
  • [0039]
    As shown in FIGS. 4, 9, and 10, in a preferred embodiment of the present invention, trailing end 104 can be machined to include openings 120, 122 for receiving bone-engaging screws 130 a, 130 b. Openings 120, 122 extend from trailing end 104 through upper and lower surfaces 106, 108, respectively, and are preferably oriented or directed toward the adjacent vertebral bodies. As shown in FIGS. 7 and 8, instead of openings 120, 122, trailing end 104 can include openings 132, 134, 136, 138, for receiving bone-engaging screws. Openings 132, 134, 136, 138 can be oriented toward upper and lower surfaces 106, 108 in an alternating manner as shown in FIG. 7. Alternatively, openings 132, 138 can be oriented toward upper surface 106 and openings 134, 136 can be oriented toward lower surface 108 as shown in FIG. 8, or any combination thereof. The number of openings in trailing end 104 can vary depending on the size of the implant and the number of screws desired to be utilized by the surgeon.
  • [0040]
    In a further embodiment of the present invention, the medulary canal 114 of bone ring implant 100 may be loaded with fusion promoting substances and/or the implant may be treated with fusion promoting substances. Such substances may include, but are not limited to, bone morphogenetic protein (BMP), genetic material coding for the production of bone, mineralizing proteins, bone or bone products, a chemical substance to inhibit scar formation, and other materials.
  • [0041]
    In a further embodiment of the present invention, the medulary canal 114, which may or may not be machined, is compressively loaded with what is at least in part fusion promoting substances to increase the density of the filled area. Potentially, this allows for an increase in the quantities of fusion promoting material and provides the ability of the filled area to bear load.
  • [0042]
    The bone ring implants, bone screws, or locks could include a bioresorbable material including, but not limited to cortical bone, plastics and composite plastics. Suitable plastics may include those comprising lactides, galactides, glycolide, capronlactone, trimethylene carbonate, dioxanone in various polymers and/or combinations.
  • [0043]
    The present invention has been described as being an improved ring of bone harvested from the diaphyseal region of a long bone. This has been done to emphasize that the implant should have a substantial ring or perimeter of cortical bone. It is not necessary that the perimeter of cortical bone be uninterrupted or complete. The perimeter of the bone ring implant may include an open portion adapted to provide access to the medulary canal 114. Further, the implant could rely on some portion of denser cancellous bone and still conform to the teachings of the present invention. The present invention can include bone harvested from the area of the diaphyseal/metaphyseal transition. If the cancellous density of a specific bone were sufficient for the graft to work in the intended manner, then a graft could be harvested from the metaphyseal region of that bone and machined in accordance with the teachings of the present invention and would be within the scope of the present invention.
  • [0044]
    While a preferred embodiment of the present invention has been described in regard to a femoral ring modified in accordance with the teachings of the present invention, the invention itself is not so limited. While a femoral ring, because of its diameter, lends itself well to use in the human adult lumbar spine, other tubular bones may be useful in various locations of a human spine. By way of example only and not limitation, rings formed through the diaphyseal region of a fibula or humerus may be used for interbody fusion in the cervical spine, while a tibial ring may be used in the thoracic or lumbar spine. Finally, the implants of the present invention may be formed from a composite material comprising cortical bone.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US245259 *2 Aug 1881 crompton
US3867728 *5 Apr 197325 Feb 1975Cutter LabProsthesis for spinal repair
US4070514 *5 Jun 197324 Jan 1978The United States Of America As Represented By The United States Department Of EnergyMethod of fabricating graphite for use as a skeletal prosthesis and product thereof
US4309777 *13 Nov 198012 Jan 1982Patil Arun AArtificial intervertebral disc
US4349921 *16 Jun 198021 Sep 1982Kuntz J DavidIntervertebral disc prosthesis
US4599086 *7 Jun 19858 Jul 1986Doty James RSpine stabilization device and method
US4714469 *26 Feb 198722 Dec 1987Pfizer Hospital Products Group, Inc.Spinal implant
US4743256 *22 Jan 198710 May 1988Brantigan John WSurgical prosthetic implant facilitating vertebral interbody fusion and method
US4834757 *28 Mar 198830 May 1989Brantigan John WProsthetic implant
US4863477 *12 May 19875 Sep 1989Monson Gary LSynthetic intervertebral disc prosthesis
US4877020 *24 May 198831 Oct 1989Vich Jose M OApparatus for bone graft
US4878915 *4 Jan 19897 Nov 1989Brantigan John WSurgical prosthetic implant facilitating vertebral interbody fusion
US4904261 *4 Aug 198827 Feb 1990A. W. Showell (Surgicraft) LimitedSpinal implants
US4911718 *10 Jun 198827 Mar 1990University Of Medicine & Dentistry Of N.J.Functional and biocompatible intervertebral disc spacer
US4950296 *13 Jun 198921 Aug 1990Mcintyre Jonathan LBone grafting units
US5015255 *10 May 198914 May 1991Spine-Tech, Inc.Spinal stabilization method
US5062845 *10 May 19895 Nov 1991Spine-Tech, Inc.Method of making an intervertebral reamer
US5071437 *21 Nov 199010 Dec 1991Acromed CorporationArtificial disc
US5123926 *22 Feb 199123 Jun 1992Madhavan PisharodiArtificial spinal prosthesis
US5192327 *22 Mar 19919 Mar 1993Brantigan John WSurgical prosthetic implant for vertebrae
US5306308 *23 Oct 199026 Apr 1994Ulrich GrossIntervertebral implant
US5306309 *4 May 199226 Apr 1994Calcitek, Inc.Spinal disk implant and implantation kit
US5338772 *22 Jun 199216 Aug 1994Merck Patent Gesellschaft Mit Beschrankter HaftungImplant material
US5397364 *12 Oct 199314 Mar 1995Danek Medical, Inc.Anterior interbody fusion device
US5425772 *20 Sep 199320 Jun 1995Brantigan; John W.Prosthetic implant for intervertebral spinal fusion
US5443514 *1 Oct 199322 Aug 1995Acromed CorporationMethod for using spinal implants
US5458638 *6 Nov 199217 Oct 1995Spine-Tech, Inc.Non-threaded spinal implant
US5484437 *10 Jun 199316 Jan 1996Michelson; Gary K.Apparatus and method of inserting spinal implants
US5607424 *10 Apr 19954 Mar 1997Tropiano; PatrickDomed cage
US5669909 *30 Mar 199523 Sep 1997Danek Medical, Inc.Interbody fusion device and method for restoration of normal spinal anatomy
US5702449 *7 Jun 199530 Dec 1997Danek Medical, Inc.Reinforced porous spinal implants
US5766252 *24 Jan 199516 Jun 1998Osteonics Corp.Interbody spinal prosthetic implant and method
US5814084 *16 Jan 199629 Sep 1998University Of Florida Tissue Bank, Inc.Diaphysial cortical dowel
US5846484 *20 Mar 19978 Dec 1998Osteotech, Inc.Pressure flow system and method for treating a fluid permeable workpiece such as a bone
US5860973 *30 Oct 199619 Jan 1999Michelson; Gary KarlinTranslateral spinal implant
US5861041 *7 Apr 199719 Jan 1999Arthit SitisoIntervertebral disk prosthesis and method of making the same
US5865845 *5 Mar 19962 Feb 1999Thalgott; John S.Prosthetic intervertebral disc
US5868749 *31 Jan 19979 Feb 1999Reed; Thomas M.Fixation devices
US5888227 *3 Oct 199630 Mar 1999Synthes (U.S.A.)Inter-vertebral implant
US5898749 *15 Jan 199727 Apr 1999Vattenfall AbSteam blowing assembly for nuclear power plants
US5899939 *21 Jan 19984 May 1999Osteotech, Inc.Bone-derived implant for load-supporting applications
US5972368 *11 Jun 199726 Oct 1999Sdgi Holdings, Inc.Bone graft composites and spacers
US5989289 *9 Oct 199723 Nov 1999Sdgi Holdings, Inc.Bone grafts
US6033438 *3 Jun 19977 Mar 2000Sdgi Holdings, Inc.Open intervertebral spacer
US6080155 *27 Feb 199527 Jun 2000Michelson; Gary KarlinMethod of inserting and preloading spinal implants
US6159214 *31 Jul 199612 Dec 2000Michelson; Gary K.Milling instrumentation and method for preparing a space between adjacent vertebral bodies
US6224607 *25 Jan 20001 May 2001Gary K. MichelsonInstrumentation and method for creating an intervertebral space for receiving an implant
US6231610 *25 Aug 199915 May 2001Allegiance CorporationAnterior cervical column support device
US6241770 *5 Mar 19995 Jun 2001Gary K. MichelsonInterbody spinal fusion implant having an anatomically conformed trailing end
US6241771 *10 Aug 19985 Jun 2001Cambridge Scientific, Inc.Resorbable interbody spinal fusion devices
US6245108 *31 Jan 200012 Jun 2001SpinecoSpinal fusion implant
US6258125 *30 Jul 199910 Jul 2001Synthes (U.S.A.)Intervertebral allograft spacer
US6277149 *8 Jun 199921 Aug 2001Osteotech, Inc.Ramp-shaped intervertebral implant
US6294187 *23 Feb 199925 Sep 2001Osteotech, Inc.Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6350283 *19 Apr 200026 Feb 2002Gary K. MichelsonBone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof
US6371988 *18 Jan 200016 Apr 2002Sdgi Holdings, Inc.Bone grafts
US6383221 *8 Aug 20017 May 2002Osteotech, Inc.Method for forming an intervertebral implant
US6410519 *3 Mar 200025 Jun 2002United States Surgical CorporationScar reduction
US6423095 *20 Feb 199623 Jul 2002Sdgi Holdings, Inc.Intervertebral spacers
US6428576 *14 Apr 20006 Aug 2002Endospine, Ltd.System for repairing inter-vertebral discs
US6471724 *5 Feb 200129 Oct 2002Sdgi Holdings, Inc.Methods and instruments for interbody fusion
US6511509 *7 May 199828 Jan 2003LifenetTextured bone allograft, method of making and using same
US6562072 *20 Jul 200013 May 2003Aesculap Ag & Co. KgImplant for insertion between spinal column vertebrae
US6610065 *27 Oct 200026 Aug 2003Sdgi Holdings, Inc.Interbody fusion implants and instrumentation
US6645206 *3 Mar 200011 Nov 2003Sdgi Holdings, Inc.Interbody fusion device and method for restoration of normal spinal anatomy
US6666888 *23 Aug 200023 Dec 2003Roger P. JacksonThreaded fusion cage with enhanced anterior support
US6666890 *28 Aug 200123 Dec 2003Gary K. MichelsonBone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof
US6689167 *31 Dec 200110 Feb 2004George W. BagbyMethod of using spinal fusion device, bone joining implant, and vertebral fusion implant
US6706067 *5 Nov 200116 Mar 2004Osteotech, Inc.Spinal intervertebral implant and method of making
US6709458 *29 Jan 200123 Mar 2004Gary Karlin MichelsonExpandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion
US6749636 *2 Apr 200215 Jun 2004Gary K. MichelsonContoured spinal fusion implants made of bone or a bone composite material
US6827740 *8 Dec 19997 Dec 2004Gary K. MichelsonSpinal implant surface configuration
US6902581 *24 Oct 20017 Jun 2005Kowmedica Osteonics Corp.Apparatus for fusing adjacent bone structure
US6989031 *2 Apr 200224 Jan 2006Sdgi Holdings, Inc.Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite
US6989289 *4 Aug 200024 Jan 2006Matsushita Electric Industrial Co., Ltd.Electrolytic capacitor and method of producing the same
US7022137 *16 Dec 20034 Apr 2006Sdgi Holdings, Inc.Bone hemi-lumbar interbody spinal fusion implant having an asymmetrical leading end and method of installation thereof
US7077866 *16 Feb 200118 Jul 2006Depuy Mitek, Inc.Resorbable interbody spinal fusion devices
US7094239 *5 May 200022 Aug 2006Sdgi Holdings, Inc.Screws of cortical bone and method of manufacture thereof
US7156875 *7 Nov 20032 Jan 2007Warsaw Orthopedic, Inc.Arcuate artificial hemi-lumbar interbody spinal fusion implant having an asymmetrical leading end
US7387643 *7 Nov 200317 Jun 2008Warsaw Orthopedic, Inc.Method for installation of artificial hemi-lumbar interbody spinal fusion implant having an asymmetrical leading end
US7435262 *15 Jun 200414 Oct 2008Warsaw Orthopedic, Inc.Contoured cortical bone implants
US7462195 *19 Apr 20009 Dec 2008Warsaw Orthopedic, Inc.Artificial lumbar interbody spinal implant having an asymmetrical leading end
US7611536 *24 Jan 20063 Nov 2009Warsaw Orthopedic, Inc.Hemi-interbody spinal fusion implants manufactured from a major long bone ring
US20010034553 *29 Jan 200125 Oct 2001Michelson Gary KarlinExpandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion
US20020029081 *8 Aug 20017 Mar 2002Scarborough Nelson L.Method for forming an intervertebral implant
US20020111680 *15 Nov 200115 Aug 2002Michelson Gary K.Ratcheted bone dowel
US20020161442 *2 Apr 200231 Oct 2002Michelson Gary K.Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite
US20030130737 *6 Aug 200210 Jul 2003Mcgahan Thomas V.Anterior impacted bone graft and driver instruments
US20030195517 *6 May 200316 Oct 2003Michelson Gary K.Instrumentation for creating an intervertebral space for receiving an implant
US20040215203 *24 May 200428 Oct 2004Michelson Gary K.Bone removal device
US20040230308 *15 Jun 200418 Nov 2004Michelson Gary K.Contoured cortical bone implants
US20040249388 *1 Jul 20049 Dec 2004Michelson Gary K.Distractor with opening
US20050004672 *18 Feb 20046 Jan 2005John PaffordBone grafts
US20050171607 *24 Mar 20054 Aug 2005Michelson Gary K.Manufactured bone composite implant shaped to conform to a prepared implantation space
US20050256574 *10 Jun 200517 Nov 2005Paul David CIntervertebral allograft spacer
US20050267578 *27 Jun 20051 Dec 2005Michelson Gary KRatcheted bone dowel having smooth sides and method for use thereof
US20060122702 *24 Jan 20068 Jun 2006Michelson Gary KHemi-interbody spinal fusion implants manufactured from a major long bone ring
US20060235519 *3 Apr 200619 Oct 2006Sdgi Holdings, Inc.Bone hemi-lumbar arcuate interbody spinal fusion implant having an asymmetrical leading end
US20100030333 *2 Oct 20094 Feb 2010Michelson Gary KHemi-interbody spinal fusion implants manufactured from a major long bone ring
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US773638021 Dec 200515 Jun 2010Rhausler, Inc.Cervical plate system
US810538324 Mar 200531 Jan 2012Warsaw Orthopedic, Inc.Manufactured bone composite implant shaped to conform to a prepared implantation space
US819249228 Jun 20075 Jun 2012Zimmer Spine, Inc.Spinal implant
US84546943 Mar 20114 Jun 2013Warsaw Orthopedic, Inc.Interbody device and plate for spinal stabilization and instruments for positioning same
US848074711 Aug 20109 Jul 2013Warsaw Orthopedic, Inc.Interbody spinal implants with extravertebral support plates
US85407745 Nov 200824 Sep 2013DePuy Synthes Products, LLCLow profile intervertebral implant
US856848424 May 201229 Oct 2013Zimmer Spine, Inc.Spinal implant
US8652209 *2 Jul 201218 Feb 2014ClarianceNuclear implant
US86909488 Apr 20138 Apr 2014Warsaw Orthopedic, Inc.Interbody device and plate for spinal stabilization and instruments for positioning same
US88280829 Jul 20109 Sep 2014R Tree Innovations, LlcInter-body implant
US884573730 May 201330 Sep 2014Warsaw Orthopedic, Inc.Interbody spinal implants with extravertebral support plates
US900529527 Aug 201214 Apr 2015DePuy Synthes Products, LLCLow profile intervertebral implant
US91800197 Feb 201410 Nov 2015Warsaw Orthopedic, Inc.Interbody device and plate for spinal stabilization and instruments for positioning same
US92541301 Nov 20129 Feb 2016Hyun BaeBlade anchor systems for bone fusion
US948051123 Jan 20131 Nov 2016Engage Medical Holdings, LlcBlade fixation for ankle fusion and arthroplasty
US952653215 Sep 201527 Dec 2016Warsaw Orthopedic, Inc.Interbody device and plate for spinal stabilization and instruments for positioning same
US961594016 May 201611 Apr 2017Warsaw Orthopedic, Inc.Interbody device and plate for spinal stabilization and instruments for positioning same
US97308045 May 201015 Aug 2017Warsaw Orthopedic, Inc.Locking spinal fusion device
US97440492 Mar 201529 Aug 2017DePuy Synthes Products, Inc.Low profile intervertebral implant
US98145999 Jul 201014 Nov 2017R Tree Innovations, LlcInter-body implantation system and method
US984899230 Nov 201526 Dec 2017DePuy Synthes Products, Inc.Intervertebral implants, systems, and methods of use
US20050171607 *24 Mar 20054 Aug 2005Michelson Gary K.Manufactured bone composite implant shaped to conform to a prepared implantation space
US20050267578 *27 Jun 20051 Dec 2005Michelson Gary KRatcheted bone dowel having smooth sides and method for use thereof
US20080200985 *28 Jun 200721 Aug 2008Zimmer Spine, Inc.Spinal implant
US20080208342 *15 Jun 200728 Aug 2008Zimmer Spine, Inc.Spinal implant
US20090299412 *2 Feb 20073 Dec 2009Trinity OrthopedicsPercutaneous facet joint fusion system and method
US20120277862 *2 Jul 20121 Nov 2012ClarianceNuclear implant
Classifications
U.S. Classification623/17.11
International ClassificationA61F2/00, A61F2/02, A61F2/28, A61F2/30, A61B17/86, A61F2/44
Cooperative ClassificationA61F2002/30841, A61F2002/4475, A61F2002/30787, A61F2/4465, A61B17/86, A61F2002/30904, A61F2/442, A61F2210/0004, A61F2/30965, A61F2310/00179, A61F2002/2817, A61F2002/30892, A61F2002/30062, A61F2/28
European ClassificationA61F2/44F4, A61F2/28
Legal Events
DateCodeEventDescription
17 Jun 2005ASAssignment
Owner name: SDGI HOLDINGS, INC., DELAWARE
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MICHELSON, GARY KARLIN;KARLIN TECHNOLOGY, INC.;REEL/FRAME:016195/0282
Effective date: 20050517
Owner name: SDGI HOLDINGS, INC.,DELAWARE
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MICHELSON, GARY KARLIN;KARLIN TECHNOLOGY, INC.;REEL/FRAME:016195/0282
Effective date: 20050517
28 Nov 2006ASAssignment
Owner name: WARSAW ORTHOPEDIC, INC., INDIANA
Free format text: MERGER;ASSIGNOR:SDGI HOLDINGS, INC.;REEL/FRAME:018552/0456
Effective date: 20060428