US20050085734A1 - Heart failure patient treatment and management device - Google Patents
Heart failure patient treatment and management device Download PDFInfo
- Publication number
- US20050085734A1 US20050085734A1 US10/966,487 US96648704A US2005085734A1 US 20050085734 A1 US20050085734 A1 US 20050085734A1 US 96648704 A US96648704 A US 96648704A US 2005085734 A1 US2005085734 A1 US 2005085734A1
- Authority
- US
- United States
- Prior art keywords
- patient
- parameter
- respiration
- condition
- cardiac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010019280 Heart failures Diseases 0.000 title claims abstract description 34
- 230000029058 respiratory gaseous exchange Effects 0.000 claims abstract description 107
- 230000000747 cardiac effect Effects 0.000 claims abstract description 55
- 230000000694 effects Effects 0.000 claims abstract description 52
- 206010037423 Pulmonary oedema Diseases 0.000 claims abstract description 19
- 208000005333 pulmonary edema Diseases 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 18
- 206010030113 Oedema Diseases 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims description 25
- 229940079593 drug Drugs 0.000 claims description 24
- 238000012544 monitoring process Methods 0.000 claims description 18
- 230000033001 locomotion Effects 0.000 claims description 12
- 230000000875 corresponding effect Effects 0.000 claims description 8
- 230000009471 action Effects 0.000 claims description 6
- 230000003187 abdominal effect Effects 0.000 claims description 4
- 230000002596 correlated effect Effects 0.000 claims description 3
- 210000000115 thoracic cavity Anatomy 0.000 claims description 3
- 230000036541 health Effects 0.000 claims description 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 17
- 208000024891 symptom Diseases 0.000 abstract description 7
- 201000010099 disease Diseases 0.000 abstract description 4
- 238000007726 management method Methods 0.000 description 16
- 238000004891 communication Methods 0.000 description 14
- 208000035475 disorder Diseases 0.000 description 13
- 208000000122 hyperventilation Diseases 0.000 description 13
- 230000000870 hyperventilation Effects 0.000 description 13
- 230000000737 periodic effect Effects 0.000 description 11
- 230000000241 respiratory effect Effects 0.000 description 11
- 206010003658 Atrial Fibrillation Diseases 0.000 description 7
- 208000008784 apnea Diseases 0.000 description 7
- 206010047302 ventricular tachycardia Diseases 0.000 description 7
- 230000036471 bradycardia Effects 0.000 description 6
- 208000003663 ventricular fibrillation Diseases 0.000 description 6
- 208000006218 bradycardia Diseases 0.000 description 5
- 239000002934 diuretic Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 208000003417 Central Sleep Apnea Diseases 0.000 description 4
- 206010008501 Cheyne-Stokes respiration Diseases 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 210000003105 phrenic nerve Anatomy 0.000 description 4
- 239000005541 ACE inhibitor Substances 0.000 description 3
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 3
- 239000002876 beta blocker Substances 0.000 description 3
- 229940097320 beta blocking agent Drugs 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000001882 diuretic effect Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 238000002483 medication Methods 0.000 description 3
- 230000036387 respiratory rate Effects 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- 206010007559 Cardiac failure congestive Diseases 0.000 description 2
- 206010021079 Hypopnoea Diseases 0.000 description 2
- 206010037368 Pulmonary congestion Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 229940030606 diuretics Drugs 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 230000004217 heart function Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 208000020446 Cardiac disease Diseases 0.000 description 1
- 206010007558 Cardiac failure chronic Diseases 0.000 description 1
- 206010058490 Hyperoxia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- 230000035565 breathing frequency Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000004903 cardiac system Anatomy 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- -1 e.g. Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000000222 hyperoxic effect Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000008035 nerve activity Effects 0.000 description 1
- 208000001797 obstructive sleep apnea Diseases 0.000 description 1
- 238000011022 operating instruction Methods 0.000 description 1
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000000718 qrs complex Methods 0.000 description 1
- 238000000306 qrs interval Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 230000001515 vagal effect Effects 0.000 description 1
- 208000021816 ventricular bradycardia Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36132—Control systems using patient feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/389—Electromyography [EMG]
- A61B5/395—Details of stimulation, e.g. nerve stimulation to elicit EMG response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/389—Electromyography [EMG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4806—Sleep evaluation
- A61B5/4818—Sleep apnoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
Abstract
A device and method to detect and manage heart failure patient symptoms is provided. Respiration and/or cardiac parameters may be sensed or observed to determine the status of a patient's condition. These symptoms may be classified for appropriate patient disease management. A patient's activity level may be monitored in conjunction with respiration and/or cardiac parameters to provide additional patient status information. These symptoms may be classified for appropriate patient disease management. Pulmonary edema is one condition that may be determined to exist when a respiration parameter is out of range for a given sensed activity level. If edema is determined to be present, the device may be configured to respond to treat the edema.
Description
- This application is a continuation-in-part of U.S. patent application Ser. No. 10/686,891, entitled: “BREATHING DISORDER DETECTION AND THERAPY DELIVERY DEVICE AND METHOD”, by Tehrani filed Oct. 15, 2003, and incorporated herein by reference.
- The invention relates to devices and methods for managing heart failure patients by monitoring cardiac and/or respiration parameters and identifying the severity of heart failure/cardiac and/or pulmonary disorders. Another aspect includes monitoring pulmonary edema.
- A number of cardiac parameters are believed to be predictors of adverse outcomes in heart failure patients. Such parameters may relate, for example, to aspects of the ECG waveform and to heart rate.
- Patients with heart failure are prone to a variety of cardiac arrhythmias that may have an important role in cardiac function, symptoms and prognosis.
- General cardiac arrhythmias, including atrial fibrillation, ventricular tachycardia, and ventricular fibrillation have been monitored with pacemakers and defibrillators and are known to indicate improving or worsening of the patient's heart rhythms. The monitored information has been downloaded from these devices for such monitoring purposes.
- However, such monitoring has not been used to provide comprehensive patient management.
- Disordered breathing may contribute to a number of adverse cardiovascular outcomes such as hypertension, stroke, congestive heart failure, and myocardial infarction. Sleep-related breathing disorders, especially central sleep apnea, have been found to have a relatively high prevalence in patients with heart failure and may have a causative or influencing effect on heart failure. In about 50% of patients with stable congestive heart failure, there is an associated sleep disordered breathing, predominantly central sleep apnea, with a minority having obstructive sleep apnea. Furthermore, sleep related breathing disorders are believed to be physiologically linked with heart failure. Central sleep apnea is a known risk factor for diminished life expectancy in heart failure. It is also believed that in view of this link, treatment aimed at relieving sleep related breathing disorders may improve cardiovascular outcomes in patients with heart failure.
- Pulmonary edema, a condition in which there is excess fluid in the lungs and often found in heart failure patients, is believed in some circumstances to lead to hyperventilation and hyperoxia or apnea. Most heart failure patients with central sleep apnea, when lying flat, tend to have central fluid accumulation and pulmonary congestion, which may stimulate vagal irritant receptors in the lungs to cause reflex hyperventilation. A severe form of pulmonary edema or fluid accumulation is known as decompensation.
- While breathing disorders have been treated a number of ways, a comprehensive patient management with breathing disorder or pulmonary edema monitoring has not been provided.
- Heart failure patients are prescribed on
average 11 medications. Management of these patients has proven difficult particularly with the complexity of the various medications and patient lifestyle and drug compliance issues. Patient compliance tracking has been shown to decrease hospital rates and improve quality of life leading to reduced healthcare costs. However, this tracking system did not provide comprehensive patient monitoring. - The present invention provides a device and method for managing heart failure patients that utilizes cardiac and/or respiration monitoring. In addition to monitoring cardiac or respiration parameters, a patient's activity level may be monitored to further discern a level of patient condition severity. One aspect includes monitoring cardiac and/or respiratory conditions or states to detect decompensation. Another aspect includes monitoring cardiac and/or respiratory condition/states to predict, sense or detect decompensation. Decompensation typically requires urgent emergency care. Decompensation typically occurs when cardiac filling pressure increases, lungs fill with fluids, and cardiac output cannot meet the body's needs at rest. Another aspect includes sensing edema.
- According to one aspect of the invention, one or more cardiac parameters may be monitored. The cardiac parameters may be monitored with an implanted device and its related electrodes from a location outside of the heart. In one particular example, an ECG may be sensed using electrodes positioned on the diaphragm. The electrodes may be positioned on a surface of the diaphragm such as the abdominal side. The thoracic side may be used as well. The phrenic nerve at or adjacent the diaphragm may also be used to sense ECG.
- Additionally or alternatively one or more respiration parameters are monitored.
- The observed parameter or parameters are used to determine a level of condition severity. In one particular variation, the shift from a baseline or normal parameter or parameters is used to determine the severity of the patient's condition. Based on that level, a course of action is provided for a patient.
- One aspect of the invention provides for decompensation monitoring. As decompensation is developing, the ECG QRS and QT periods increase. The respiratory parameters also change as breathing becomes more rapid and shallow as compared to a baseline. Also, in some situations, pulmonary edema severity may increase.
- One aspect of the invention provides for pulmonary edema monitoring, an indicator of heart failure status. According to this aspect of the invention, a pulmonary monitoring device senses a patient activity level and at least one respiration parameter. For example, a low or at rest activity level with a high or out of range respiration rate may indicate existence or a worsening of pulmonary edema. Other respiration parameters relative to a patient's activity level may indicate a worsening pulmonary edema condition. If a patient's respiratory rate increases with an increase in activity and decreases with a decrease in activity, within a normal range, the patient's system will be considered functioning normally. This information may be used in a patient management scheme that also monitors drug titrations, diuretic use, ACE Inhibitors, Beta Blockers and patient compliance.
- Based on the observed parameters and/or compliance information a course of action may be provided or suggested. A provider may use the information in developing an optimum treatment plan for the patient including medication management, e.g. of drug titrations, diuretics, ACE inhibitors, and beta blockers. The system may also provide alarms and patient or provider communications if patient is in need of urgent attention possibly leading to hospitalization. This is a frequent occurrence with heart failure patients in decompensation. The patient compliance information may also be used for understanding the drug regimen effectiveness or dosing, whether the patient complies, or it may be used to educate the patient when there is lack of compliance with the therapy plan. If the patient's symptoms are brought more towards a normal range with a drug dose, then the drug treatment would be maintained. If the drug treatment did not affect the patient's symptoms sufficiently then the drug dosage may be increased. Accordingly, the drug dosage may vary with detected cardiac and/or breathing irregularities.
- According to an aspect of the invention, the patient monitoring system provides continuous monitoring of physiological parameters to detect baseline shifts in cardiac and respiratory functions. This monitoring assists in supporting the patient with lifestyle and medication compliance. It further allows tiered intervention by providing daily patient self-management feedback, intervention according to programmed parameters by the physician (e.g., by increasing or decreasing medication), providing alerts to make office visits (including office visit scheduling), and providing urgent alerts for emergency room visits.
-
FIG. 1 illustrates a heart failure management system in accordance with the invention. -
FIG. 2 is a flow chart illustrating a severity classification scheme for an awake patient with a low activity level. -
FIG. 3 is a flow chart illustrating a severity classification scheme for an awake patient with a medium activity level. -
FIG. 4 is a flow chart illustrating a severity classification scheme for an awake patient with a high activity level. -
FIG. 5 is a flow chart illustrating a severity classification scheme for a sleeping patient. -
FIG. 6 is a flow chart illustrating the operation of a heart failure management device in accordance with the invention. -
FIG. 7 is a chart illustrating an averaging method according to a patient disorder classification scheme in accordance with the invention. -
FIG. 8 is a schematic of an external controller that may be used for communications, data transfer and device programming. - Referring to
FIG. 1 , a heartfailure management system 10 in accordance with the invention is illustrated. The system includes asensor assembly 20, which in this particular illustration is coupled to adiaphragm 15 of a subject. More specifically the sensor assembly is located on the abdominal side of the diaphragm. However, one or more sensors that sense cardiac parameters or respiration parameters as may be used according to the invention, and may be positioned elsewhere in, on or adjacent a subject, including without limitation, on the thoracic side of the diaphragm or on the phrenic nerve at or adjacent the diaphragm. - The
sensor assembly 20 comprises anelectrode sensor 21 configured to sense signals from the phrenic nerve and/or diaphragm muscle. The signals may comprise a diaphragm EMG, phrenic nerve signals corresponding to respiration and/or an ECG signal. Thesensor assembly 20 also includes amotion sensor 22 such as, e.g., an accelerometer. Themotion sensor 22 may sense movement of thediaphragm 15 corresponding to respiration and/or other movement such as gross movements corresponding to subject activity. - The
sensor assembly 20 is in communication with acontroller 30 that includes signal processing circuits for processing signals from thesensors controller 30 also includes RAM memory and ROM memory. The memory devices contain programming information for controlling the device and processing signal information. The memory devices also include recording/data storage for recording data sensed by the sensors. The controller also includes an input/output device for communicating with the sensors and other devices such as external communication and controlling devices. The controller may also receive programming information from an external device. - In general, cardiac parameters that are sensed may indicate a condition of a heart failure patient. Such parameters may include ECG parameters, for example, QRS duration (typically duration of QRS complex in the frontal plane), QT interval (typically measured from the beginning of QRS to the end of T wave in the frontal plane), PR interval (typically measured from the beginning of P to the beginning of QRS in the frontal plane). As the heart failure worsens, the width of the QRS interval increases. Variations in QRS width could also be an indicator of a condition status. Similarly, QT dispersion may indicate an increase in heart failure. PR may indicate atrial conduction disturbances.
- Incidences of atrial fibrillation, ventricular arrhythmia, and bradycardia may be detected, recorded or counted by sensing an ECG. Increase in these events may indicate a worsening of the heart failure patient's condition.
- Heart rate and/or heart rate variability are cardiac parameters that may be sensed to indicate a condition status of a heart failure patient. Heart rate variability (HRV) for example, is a marker for autonomic tone and a risk predictor of part infarction mortality. Heart failure patients with worsening symptoms often have a decrease in their HRV.
- In general respiratory parameters that are sensed may indicate a worsening of a heart failure patient's condition. Such worsening may include, but is not limited to, a worsening of pulmonary edema or decompensation.
- Some of the respiratory parameters to monitor in awake patients in accordance with activity may include but are not limited to: respiratory rate and depth (may be categorized, e.g., as normal, rapid and shallow, rapid and deep; respiratory rate and depth correlation to minute ventilation; hyperventilation; incidence of periodic breathing and duration of periodic breathing; incidence of Cheyne-Stokes breathing; and the duration of the Cheyne Stoke hyperventilation and apnea portions.
- High left-sided filling pressures and pulmonary congestion can cause rapid shallow breathing indicating a worsened condition. Rapid and deep respiration may indicate low SaO2 where a patient is compensating. Incidence of periodic breathing and duration of periodic breathing may indicate breathing patterns associated with a heart failure condition. Periodic breathing and Cheyne-Stokes breathing have higher rates of ventricular tachycardia than chronic heart failure patients without breathing disorders.
- Some of the respiratory parameters to monitor during sleep may include but are not limited to: periodic breathing episodes; apnea episodes or Cheyne-Stokes episodes; information for calculation the AHI (Apnea Hyponea Index, a standardized sleep disorder measurement), Cheyne-Stokes patterns, number of events per period of time, episode durations, and peak diaphragm EMG/tidal volume. Average and standard deviation, averages and standard deviations of these parameters may also be measured or calculated as well.
- Information that may be sensed for sensing decompensation may include any parameters that indicate an increased cardiac filling pressure and a cardiac output unable to meet the demands of the patient's physiology at rest. Such information may include, for example, an increased QRS or QT length as well as increased breathing rate, typically with shorten breathing amplitudes. These parameters may be compared to measured or otherwise set baseline parameters.
- The information that may be sensed for pulmonary edema management (e.g., of hyperventilation rate and frequency of occurrence) may include the detections rate, detection amplitude, ventilation waveform morphology including slopes and surface of inspiration waveform, slopes and surface area of exhalation waveform, recorded respiratory waveform information in conjunction with activity and position sensor information.
- The respiration information used may include all or part of a respiration waveform (e.g., length of cycle or a portion of the cycle, cycle frequency, amplitude, slope of the waveform or a portion of the waveform, waveform morphology), flow, tidal volume, peak tidal volume, averages and standard deviations breathing rate, etc. These parameters may be sensed using one or more respiration sensors, such as, e.g., EMG sensors, diaphragm, chest or other movement sensors, airway flow meters (pneumotachometer), and pressure sensors at one or more of various locations.
- The sensors may also be coupled to a processor that may recognize certain breathing patterns such as periodic breathing, Cheyne-Stokes breathing patterns. These and other types of breathing patterns may be used as precursors to other breathing disorders such as described in U.S. patent application Ser. No. ______ entitled “Breathing Disorder and Precursor Predictor and Therapy Delivery Device and Method” filed on even date herewith and incorporated in its entirety herein. The processor may compare sensed breathing patterns to baseline breathing patterns and may determine what degree of correlation there is to the baseline breathing pattern. The baseline may be a normal breathing pattern where a strong correlation indicates normal breathing and a weak correlation indicates a likely breathing disorder. The baseline may be a disordered breathing pattern where a strong correlation indicates a likely breathing disorder. The sensor or processor may identify a general rate of hyperventilation or may count the number of identified episodes, e.g., in a particular time period.
- The episodes may be correlated with an activity sensor and/or a real time clock that indicates whether the episodes are awake episodes or sleeping episodes and the level of activity of the patient, e.g., as high, medium or low, no activity.
- The
movement sensor 22 may sense acceleration and/or movement of the patient, and provide a corresponding signal to thecontroller 30. Thesensor 22 measures the activity levels of the patient and provides the signal to the controller for use in further analysis. The movement signal from the sensor is processed to provide the information indicating the activity level of the patient in conjunction with cardiac and/or respiration parameters. The sensor senses activity threshold as no activity, low, medium or high depending on the programmed threshold value. Such value may be programmed or determined for a specific patient. Using the activity sensor value and cardiac or respiratory information, the health of the cardiac and/or respiratory system may be evaluated and monitored, for example as described with reference toFIGS. 2-7 . -
FIG. 6 is a flow chart illustrating a patient management device and method in accordance with the invention. Atstep 100 the patient state is determined in real time. This may be done using an activity sensor to determine the patient's activity level. The activity sensor may indicate sleep, low activity level, medium activity level or high activity level. The invention is not limited to these activity levels. Other gradations of activity levels may be used as well. - At
step 101 which occurs in conjunction withstep 110, cardiac and/or respiration parameters are determined, i.e., either sensed or determined from sensed information. The determined parameters and activity level as are stored for a period of time, for example for a 24 hour period. The parameters used may be selected from patient to patient. The baseline information used for comparison may be preset, programmed by a provider, and/or determined on a patient by patient basis by recording non-disordered patient parameters. - The cardiac parameters may include but are not limited to the ECG deviation from a baseline for a particular activity level, QRS duration deviation for a particular activity level, atrial fibrillation incidence, ventricular tachycardia incidence, ventricular fibrillation incidence, bradycardia incidence, and QT interval deviation from baseline.
- The respiration parameters for an awake state may include, but are not limited to periodic breathing as a percentage of the total breathing during the particular state and rate of Cheyne-Stokes respiration or hyperventilation as a percentage of the total breathing during the particular state.
- The respiration parameters for a sleeping state may include but are not limited to Cheyne-Stokes duration, Cheyne-Stokes maximum amplitudes, AHI (apnea-hypopnea index) frequency of breathing, and frequency of occurrence of non-apnea hyperventilation during the particular state.
- At steps 102 a-102 d, overall condition classifications for the patient at each of the defined activity levels is determined.
- At
step 102 a illustrated in more detail inFIG. 2 , an overall condition classification of the patient in an awake state at a low activity level is determined. - At
substep 120 each of the cardiac parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 120: the ECG deviation from a baseline is weighted by factor A1; QRS duration deviation is weighted by a factor B1; atrial fibrillation incidence is weighted by a factor C1; ventricular tachycardia incidence is weighted by a factor D1; ventricular fibrillation incidence is weighted by a factor E1; bradycardia incidence is weighted by a factor F1; and QT interval deviation from baseline is weighted by a factor G1. The weighted factors are these summed. - At
substep 121 each of the respiration parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 121: periodic breathing as a percentage of the total breathing is weighted by a factor of H1 and the rate of Cheyne-Stokes respiration or hyperventilation as a percentage of the total breathing is weighted by a factor of I1. - At
substep 122 followingstep 120 the summed weighted parameters A1-G1 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A cardiac classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. These baseline shifts are exemplary and are not intended to limit the classification scheme according to the invention. - Similarly at
substep 123 followingstep 121 the summed weighted parameters H1-I1 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A respiration classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. - At
substep 124 followingstep 122 the cardiac classification is weighted as a percentage of the total overall classification with the respiration classification being weighted as the remainder percentage of the total overall classification atsubstep 125 followingstep 123. - At
substep 126, the overall classification is finally determined forstep 102 a by combining the weighted cardiac classification with the weighted respiration classification. - At
step 102 b illustrated in more detail inFIG. 5 , an overall condition classification of the patient in an awake state at patient sleep state is determined. - At
substep 150 each of the cardiac parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 150: the ECG deviation from a baseline is weighted by factor A2; QRS duration deviation is weighted by a factor B2; atrial fibrillation incidence is weighted by a factor C2; ventricular tachycardia incidence is weighted by a factor D2; ventricular fibrillation incidence is weighted by a factor E2; bradycardia incidence is weighted by a factor F2; and QT interval deviation from baseline is weighted by a factor G2. The weighted factors are then summed. - At
substep 151 each of the respiration parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 151: Cheyne-Stokes duration average during the observation period of time is weighted by a factor of J; the average of the maximum Cheyne-Stokes amplitude per occurrence during the time period is weighted by a factor of K; the AHI for the time period (the nighttime period) is weighted by a factor of L; and the frequency of occurrence of non apnea hyperventilation is weighted by a factor of M. - At
substep 152 followingstep 120 the summed weighted parameters A2-G2 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A cardiac classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. These baseline shifts are exemplary and are not intended to limit the classification scheme according to the invention. - Similarly at
substep 153 followingstep 151 the summed weighted parameters J-M are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A respiration classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. - At
substep 154 followingstep 152 the cardiac classification is weighted as a percentage of the total overall classification with the respiration classification being weighted as the remainder percentage of the total overall classification atsubstep 155 followingstep 153. - At
substep 156, the overall classification is finally determined forstep 102 b by combining the weighted cardiac classification with the weighted respiration classification. - At
step 102 c illustrated in more detail inFIG. 3 , an overall condition classification of the patient in an awake state at a medium activity level is determined. - At
substep 130 each of the cardiac parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 130: the ECG deviation from a baseline is weighted by factor A3; QRS duration deviation is weighted by a factor B3; atrial fibrillation incidence is weighted by a factor C3; ventricular tachycardia incidence is weighted by a factor D3; ventricular fibrillation incidence is weighted by a factor E3; bradycardia incidence is weighted by a factor F3; and QT interval deviation from baseline is weighted by a factor G3. The weighted factors are then summed. - At
substep 131 each of the respiration parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 131: periodic breathing as a percentage of the total breathing is weighted by a factor of H3 and the rate of Cheyne-Stokes respiration or hyperventilation as a percentage of the total breathing is weighted by a factor of I3. - At
substep 132 followingstep 130 the summed weighted parameters A3-G3 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A cardiac classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. These baseline shifts are exemplary and are not intended to limit the classification scheme according to the invention. - Similarly at
substep 133 followingstep 131 the summed weighted parameters H3-I3 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A respiration classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. - At
substep 134 followingstep 132 the cardiac classification is weighted as a percentage of the total overall classification with the respiration classification being weighted as the remainder percentage of the total overall classification atsubstep 135 followingstep 133. - At
substep 136, the overall classification is finally determined forstep 102 c by combining the weighted cardiac classification with the weighted respiration classification. - At
step 102 d illustrated in more detail inFIG. 4 , an overall condition classification of the patient in an awake state at a high activity level is determined. - At
substep 140 each of the cardiac parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 140: the ECG deviation from a baseline is weighted by factor 41; QRS duration deviation is weighted by a factor B4; atrial fibrillation incidence is weighted by a factor C4; ventricular tachycardia incidence is weighted by a factor D4; ventricular fibrillation incidence is weighted by a factor E4; bradycardia incidence is weighted by a factor F4; and QT interval deviation from baseline is weighted by a factor G4. The weighted factors are then summed. - At
substep 141 each of the respiration parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 141: periodic breathing as a percentage of the total breathing is weighted by a factor of H4 and the rate of Cheyne-Stokes respiration or hyperventilation as a percentage of the total breathing is weighted by a factor of I4. - At
substep 142 followingstep 140 the summed weighted parameters A4-G4 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A cardiac classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. These baseline shifts are exemplary and are not intended to limit the classification scheme according to the invention. - Similarly at
substep 143 followingstep 141 the summed weighted parameters H4-I4 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A respiration classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. - At
substep 144 followingstep 142 the cardiac classification is weighted as a percentage of the total overall classification with the respiration classification being weighted as the remainder percentage of the total overall classification atsubstep 145 followingstep 143. - At
substep 146, the overall classification is finally determined forstep 102 d by combining the weighted cardiac classification with the weighted respiration classification. - Referring again to
FIG. 6 , after overall Awake low classification has been determined instep 102 a and the overall sleep classification has been determined instep 102 b, if either of these classifications is severe 103 then instep 104, the physician is informed for an office visit and/or ER admission is prepared through communication with the physician and/or hospital using a communication device such as described with respect toFIG. 8 . - Otherwise in
step 105, an average of the overall classifications values for the four conditions determined in steps 1-4 is calculated in accordance with the chart illustrated inFIG. 7 . As shown inFIG. 7 , anumber - If the average is less than 1, the average is considered normal 106 and no further course of action is suggested. If the average is greater than or equal to 1 and less than 2, the average is considered mild 108 and a suggestion is made for lifestyle change and compliance with
medicine 109. Such lifestyle change may also include a suggestion for exercise. This communication may be made via a patient self management module or communication device as described with reference toFIG. 8 . If the average is greater than or equal to 2 and less than 2.5 the average is considered medium 110. The patient self management module as described inFIG. 8 accordingly provides instructions to change medication according to a physician programmed value and an office visit is scheduled 111. Alternatively, a physician may be notified and the medication dosage changed by a physician before or after an office visit. If the average is greater than or equal to 2.5, then the average is considered severe 112. Then instep 113, the physician is informed for an office visit and/or ER admission is prepared through communication with the physician and/or hospital using a communication device such as described with respect toFIG. 8 . -
FIG. 8 is a schematic of anexternal controller device 40 that may be used for communications, data transfer and device programming. Theexternal device 140 comprises aprocessor 45 for controlling the operations of the external device. Theprocessor 45 and other electrical components of theexternal device 40 are coordinated by aninternal clock 50 and apower source 51. Theprocessor 45 is coupled to atelemetry circuit 46 that includes atelemetry coil 47, areceiver circuit 48 for receiving and processing a telemetry signal that is converted to a digital signal and communicated to theprocessor 45, and atransmitter circuit 49 for processing and delivering a signal from theprocessor 45 to thetelemetry coil 46. Thetelemetry coil 47 is an RF coil or alternatively may be a magnetic coil depending on what type of coil a telemetry coil of the implantedcontroller 30 may be. - The
telemetry circuit 46 is configured to transmit to the implantedcontroller 30, signals containing, e.g., programming or other instructions or information, programmed stimulation rates and pulse widths, electrode configurations, and other device performance details. - The
telemetry circuit 46 is also configured to receive telemetry signals from the implantedcontroller 30 that may contain, e.g., sensed and/or accumulated data such as the sensed information corresponding to the cardiac and respiration parameters described herein. Such sensed data may include sensed ECG, heart rate data, sensed EMG activity, sensed nerve activity, sensed movement information whether corresponding to breathing or to patient activity. The information may contain raw or processed data or signals. The patient management system may be contained in part or in whole in the implantedsensor 30 or theexternal controller 40. Other information such as frequency and time of cardiac or respiratory events, number of cardiac or respiratory events detected in a time interval or during a sleep cycle may be included in the uploaded information as well as the correlated recorded activity level. - With respect to pulmonary edema monitoring, related parameters such as frequency of hyperventilation including time and patient activity level may be recorded and uploaded to the
external device 40. - The uploaded information may be stored in
RAM event memory 58 or may be uploaded and through anexternal port 53 to a computer, or processor, either directly or through a phone line or other communication device that may be coupled to theprocessor 45 through theexternal port 53. Theexternal device 40 also includesROM memory 57 for storing and providing operating instructions to theexternal device 40 andprocessor 45. The external device also includesRAM event memory 58 for storing uploaded event information such as sensed information and data from thecontrol unit 30, and RAM program memory 59 for system operations and future upgrades. The external device also includes abuffer 54 coupled to or that can be coupled through a port to a user-operateddevice 55 such as a keypad input or other operation devices. Finally, theexternal device 40 includes a display device 56 (or a port where such device can be connected), e.g., for display visual, audible or tactile information, alarms or pages. - The
external device 40 is configured to communicate patient disease status classifications to a handheld device, computer, or provider/hospital communications interface as described insteps steps control unit 100 in response to diuretic or other medication usage that e.g., may be input by the patient. The system could also direct the patient to rest in different positions to alleviate the present problem until help arrives. - The external device may be equipped with a palm pilot type device that connects to the phone line for downloading the patient specific information regarding patient's cardiac, respiratory or pulmonary edema status, and whether the parameters are programmed correctly. This device may allow for remote follow-up, continuous monitoring of the patient's status, effectiveness of the drug regime for a heart failure patient. The device may provide for management of medications (including, e.g., diuretics ACE inhibitors, or beta blockers) for such heart failure related conditions such as pulmonary edema. The information may be viewed by the clinician using a web browser anywhere in the world of the handheld can send a fax or notice to the physician's office once the parameters of interest are outside the programmed range. The physician may then request an office visit. The system also can send a summarized report on weekly, biweekly, or monthly as routine update based on the decision of the physician programmed in the handheld device. Medication adjustment/drug titration may be accomplished remotely. Hand-held communication protocol/technology may be magnetic or RF.
- The patient management device may be used in conjunction or incorporated into various therapy devices such as, e.g., diaphragm stimulation devices as described, for example in U.S. application Ser. No. 10/686,891, entitled: “BREATHING DISORDER DETECTION AND THERAPY DELIVERY DEVICE AND METHOD”, by Tehrani filed Oct. 15, 2003, and incorporated herein by reference.
- Safety mechanisms may be incorporated into any stimulation device in accordance with the invention. The safety feature disables the device under certain conditions. Such safety features may include a patient or provider operated switch, e.g. a magnetic switch. In addition a safety mechanism may be included that determines when patient intervention is being provided. For example, the device will turn off if there is diaphragm movement sensed without an EMG as the case would be where a ventilator is being used.
- While the invention has been described in detail with reference to preferred embodiments thereof, it will be apparent to one skilled in the art that various changes can be made, and equivalents employed, without departing from the scope of the invention.
Claims (46)
1. A patient management system comprising:
an implantable device comprising:
a physiological sensor configured to be coupled to a patient to monitor the patient, and configured to sense at least one cardiac parameter and at least one respiration parameter;
a patient condition status identifier configured to identify a patient condition status based on the at least one cardiac parameter and the at least one respiration parameter.
2. The system of claim 1 wherein the condition status corresponds to a patient's heart failure status.
3. The system of claim 1 wherein the patient status identifier further comprises a severity level sensor configured to determine a patient condition severity level.
4. The system of claim 3 further comprising a responsive element configured to recommend a patient action based on the condition severity level.
5. The system of claim 4 wherein the responsive element is configured to provide a medication intervention instruction based on the condition severity level.
6. The system of claim 4 wherein the responsive element is configured to recommend a lifestyle modification.
7. The system of claim 4 wherein the responsive element is configured to recommend a provider intervention.
8. The system of claim 4 wherein the responsive element is configured to recommend an emergency intervention.
9. The system of claim 1 further comprising a patient status communicator coupled to the patient status identifier and configured to communicate a patient status to a user.
10. The system of claim 9 wherein the user is a patient.
11. The system of claim 9 wherein the user is a health care provider.
12. The system of claim 1 further comprising an activity monitor configured to detect patient activity.
13. The system of claim 12 wherein the physiological sensor is further configured to correlate an activity level sensed by the activity monitor with one or more of the at least one cardiac parameter and the at least one respiration parameter.
14. The system of claim 13 wherein the correlated activity with the at least one parameter further qualifies the patient status.
15. The system of claim 1 wherein the patient status identifier comprises a baseline comparator configured to compare a baseline to the at least one parameter.
16. The system of claim 15 wherein the patient status identifier is configured to identify a patient condition severity level at least in part based on the comparison of the baseline to the at least one parameter.
17. The system of claim 1 wherein the device further comprises a patient compliance monitor.
18. The system of claim 1 wherein the physiological parameter sensor is configured to sense a plurality of parameters and wherein the patient status identifier is configured to identify the patient condition status based the plurality of parameters
19. The system of claim 1 , wherein the physiological parameter sensor is configured to sense the cardiac parameter from a location external to a patient's heart.
20. The system of claim 1 wherein the physiological parameter sensor is configured to continuously monitor at least one parameter.
21. The system of claim 1 wherein the patient condition status identifier is configured to identify a patient decompensating status.
22. A method of managing a patient comprising the steps of:
continuously monitoring at least one cardiac parameter and at least one respiration parameter;
sensing the at least one cardiac parameter and at least one respiration parameter; and
identifying a patient status based on the at least one cardiac parameter and at least one respiration parameter.
23. The method of claim 22 further comprising the step of determining a patient condition severity level based on the at least one cardiac parameter and at least one respiration parameter.
24. The method of claim 23 further comprising the step of recommending a patient course of action based on the patient condition severity level.
25. The method of claim 23 further comprising the step of communicating the patient condition severity level to the patient.
26. The method of claim 23 further comprising the step of communicating the patient condition severity level to a healthcare provider.
27. A device for detecting pulmonary edema comprising
a first sensor configured to sense activity of a subject and to generate a first signal corresponding to the activity of a subject;
a second sensor configured to sense at least one respiration parameter of the subject and generate a second signal corresponding to the at least on respiration parameter; and
an edema analyzer coupled to the first sensor and the second sensor, the edema analyzer configured to sense edema based on the first signal and the second signal.
28. The device of claim 27 wherein the first sensor is configured to sense motion of a subject.
29. The device of claim 27 wherein the at least one respiration parameter comprises a respiration rate.
30. The device of claim 27 wherein the at least one respiration parameter comprises a morphology of a respiration waveform.
31. The device of claim 27 wherein the edema detector is configured to detect edema when a sensed respiration rate exceeds a predetermined level of a sensed activity level.
32. A method for detecting pulmonary edema comprising the steps of:
sensing activity of a subject;
sensing at least one respiration parameter of the subject; and
determining a pulmonary edema condition based on the activity and respiration parameter of the subject.
33. The method of claim 32 wherein the step of determining pulmonary edema condition comprises determining a relative severity level of the pulmonary edema condition.
34. A patient management system comprising:
an implantable device comprising:
a physiological sensor configured to be coupled to a patient to continuously monitor the patient, and configured to sense at least one physiological parameter selected from: at least one cardiac parameter sensed from a location external the heart and at least one respiration parameter;
a patient condition status identifier configured to identify a patient condition status based on the at least one physiological parameter.
35. The system of claim 34 wherein the condition status corresponds to a patient's heart failure status.
36. The system of claim 34 wherein the patient status identifier further comprises a severity level sensor configured to determine a patient condition severity level.
37. The system of claim 36 further comprising a responsive element configured to recommend a patient action based on the condition severity level.
38. The system of claim 37 wherein the responsive element is configured to provide a medication intervention instruction based on the condition severity level.
39. The system of claim 37 wherein the responsive element is configured to recommend a lifestyle modification.
40. The system of claim 37 wherein the responsive element is configured to recommend a provider intervention.
41. The system of claim 37 wherein the responsive element is configured to recommend an emergency intervention.
42. A device for sensing cardiac parameters comprising:
at least one electrode configured to be positioned adjacent a diaphragm of a subject and configured to sense an ECG signal.
43. The device of claim 43 wherein the at least one electrode is configured to be positioned on the abdominal surface of a diaphragm.
44. A method for sensing cardiac parameters comprising:
positioning an electrode adjacent a diaphragm of a subject; and
sensing an ECG with the diaphragm.
45. The method of claim 44 wherein the step of positioning the electrode adjacent the diaphragm comprises positioning the electrode at the abdominal side of the diaphragm.
46. The method of claim 44 wherein the step of positioning the electrode adjacent the diaphragm comprises positioning the electrode at the thoracic side of the diaphragm.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/966,487 US20050085734A1 (en) | 2003-10-15 | 2004-10-15 | Heart failure patient treatment and management device |
US13/598,284 US20120323293A1 (en) | 2003-10-15 | 2012-08-29 | Device and method for treating disorders of the cardiovascular system or heart |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/686,891 US8467876B2 (en) | 2003-10-15 | 2003-10-15 | Breathing disorder detection and therapy delivery device and method |
US10/966,487 US20050085734A1 (en) | 2003-10-15 | 2004-10-15 | Heart failure patient treatment and management device |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/686,891 Continuation-In-Part US8467876B2 (en) | 2003-10-15 | 2003-10-15 | Breathing disorder detection and therapy delivery device and method |
US11/480,074 Continuation-In-Part US8160711B2 (en) | 2003-10-15 | 2006-06-29 | Multimode device and method for controlling breathing |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/271,264 Continuation-In-Part US7979128B2 (en) | 2003-10-15 | 2005-11-10 | Device and method for gradually controlling breathing |
Publications (1)
Publication Number | Publication Date |
---|---|
US20050085734A1 true US20050085734A1 (en) | 2005-04-21 |
Family
ID=34465515
Family Applications (15)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/686,891 Active 2026-09-30 US8467876B2 (en) | 2003-10-15 | 2003-10-15 | Breathing disorder detection and therapy delivery device and method |
US10/966,421 Active 2026-02-19 US8255056B2 (en) | 2003-10-15 | 2004-10-15 | Breathing disorder and precursor predictor and therapy delivery device and method |
US10/966,484 Abandoned US20050085869A1 (en) | 2003-10-15 | 2004-10-15 | System and method for mapping diaphragm electrode sites |
US10/966,474 Active 2025-11-29 US8412331B2 (en) | 2003-10-15 | 2004-10-15 | Breathing therapy device and method |
US10/966,472 Active 2026-12-07 US8200336B2 (en) | 2003-10-15 | 2004-10-15 | System and method for diaphragm stimulation |
US10/966,487 Abandoned US20050085734A1 (en) | 2003-10-15 | 2004-10-15 | Heart failure patient treatment and management device |
US11/246,439 Abandoned US20060030894A1 (en) | 2003-10-15 | 2005-10-11 | Breathing disorder detection and therapy device for providing intrinsic breathing |
US11/249,718 Active 2024-09-20 US8348941B2 (en) | 2003-10-15 | 2005-10-13 | Demand-based system for treating breathing disorders |
US11/526,949 Expired - Fee Related US8509901B2 (en) | 2003-10-15 | 2006-09-25 | Device and method for adding to breathing |
US11/981,831 Abandoned US20080183240A1 (en) | 2003-10-15 | 2007-10-31 | Device and method for manipulating minute ventilation |
US11/981,727 Abandoned US20080183239A1 (en) | 2003-10-15 | 2007-10-31 | Breathing therapy device and method |
US11/981,800 Active 2024-12-08 US8116872B2 (en) | 2003-10-15 | 2007-10-31 | Device and method for biasing and stimulating respiration |
US12/080,133 Abandoned US20080188903A1 (en) | 2003-10-15 | 2008-04-01 | Device and method for biasing and stimulating respiration |
US13/851,003 Abandoned US20130296973A1 (en) | 2003-10-15 | 2013-03-26 | Breathing therapy device and method |
US13/915,316 Abandoned US20130296964A1 (en) | 2003-10-15 | 2013-06-11 | Breathing disorder detection and therapy delivery device and method |
Family Applications Before (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/686,891 Active 2026-09-30 US8467876B2 (en) | 2003-10-15 | 2003-10-15 | Breathing disorder detection and therapy delivery device and method |
US10/966,421 Active 2026-02-19 US8255056B2 (en) | 2003-10-15 | 2004-10-15 | Breathing disorder and precursor predictor and therapy delivery device and method |
US10/966,484 Abandoned US20050085869A1 (en) | 2003-10-15 | 2004-10-15 | System and method for mapping diaphragm electrode sites |
US10/966,474 Active 2025-11-29 US8412331B2 (en) | 2003-10-15 | 2004-10-15 | Breathing therapy device and method |
US10/966,472 Active 2026-12-07 US8200336B2 (en) | 2003-10-15 | 2004-10-15 | System and method for diaphragm stimulation |
Family Applications After (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/246,439 Abandoned US20060030894A1 (en) | 2003-10-15 | 2005-10-11 | Breathing disorder detection and therapy device for providing intrinsic breathing |
US11/249,718 Active 2024-09-20 US8348941B2 (en) | 2003-10-15 | 2005-10-13 | Demand-based system for treating breathing disorders |
US11/526,949 Expired - Fee Related US8509901B2 (en) | 2003-10-15 | 2006-09-25 | Device and method for adding to breathing |
US11/981,831 Abandoned US20080183240A1 (en) | 2003-10-15 | 2007-10-31 | Device and method for manipulating minute ventilation |
US11/981,727 Abandoned US20080183239A1 (en) | 2003-10-15 | 2007-10-31 | Breathing therapy device and method |
US11/981,800 Active 2024-12-08 US8116872B2 (en) | 2003-10-15 | 2007-10-31 | Device and method for biasing and stimulating respiration |
US12/080,133 Abandoned US20080188903A1 (en) | 2003-10-15 | 2008-04-01 | Device and method for biasing and stimulating respiration |
US13/851,003 Abandoned US20130296973A1 (en) | 2003-10-15 | 2013-03-26 | Breathing therapy device and method |
US13/915,316 Abandoned US20130296964A1 (en) | 2003-10-15 | 2013-06-11 | Breathing disorder detection and therapy delivery device and method |
Country Status (3)
Country | Link |
---|---|
US (15) | US8467876B2 (en) |
DE (3) | DE112004001953T5 (en) |
WO (6) | WO2005037366A1 (en) |
Cited By (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050085869A1 (en) * | 2003-10-15 | 2005-04-21 | Tehrani Amir J. | System and method for mapping diaphragm electrode sites |
US20060101871A1 (en) * | 2004-11-12 | 2006-05-18 | Matsushita Electric Industrial Co., Ltd. | Drum type washing and drying machine |
US20060122662A1 (en) * | 2003-10-15 | 2006-06-08 | Tehrani Amir J | Device and method for increasing functional residual capacity |
US20060149334A1 (en) * | 2003-10-15 | 2006-07-06 | Tehrani Amir J | Device and method for controlling breathing |
US20060155341A1 (en) * | 2003-10-15 | 2006-07-13 | Tehrani Amir J | Device and method for biasing lung volume |
US20060241512A1 (en) * | 2005-04-20 | 2006-10-26 | Cardiac Pacemakers, Inc. | Thoracic or intracardiac impedance detection with automatic vector selection |
US20060247729A1 (en) * | 2003-10-15 | 2006-11-02 | Tehrani Amir J | Multimode device and method for controlling breathing |
US20070021678A1 (en) * | 2005-07-19 | 2007-01-25 | Cardiac Pacemakers, Inc. | Methods and apparatus for monitoring physiological responses to steady state activity |
US20070043394A1 (en) * | 2005-08-22 | 2007-02-22 | Cardiac Pacemakers, Inc | Intracardiac impedance and its applications |
US20070049793A1 (en) * | 2005-08-25 | 2007-03-01 | Ignagni Anthony R | Method And Apparatus For Transgastric Neurostimulation |
US20070044669A1 (en) * | 2005-08-24 | 2007-03-01 | Geise Gregory D | Aluminum can compacting mechanism with improved actuation handle assembly |
US20070066905A1 (en) * | 2005-09-21 | 2007-03-22 | Cardiac Pacemakers, Inc. | Method and apparatus for controlling cardiac resynchronization therapy using cardiac impedance |
US7206635B2 (en) * | 2001-06-07 | 2007-04-17 | Medtronic, Inc. | Method and apparatus for modifying delivery of a therapy in response to onset of sleep |
US20070118183A1 (en) * | 2005-11-18 | 2007-05-24 | Mark Gelfand | System and method to modulate phrenic nerve to prevent sleep apnea |
US20070118054A1 (en) * | 2005-11-01 | 2007-05-24 | Earlysense Ltd. | Methods and systems for monitoring patients for clinical episodes |
US20070150023A1 (en) * | 2005-12-02 | 2007-06-28 | Ignagni Anthony R | Transvisceral neurostimulation mapping device and method |
US20070265611A1 (en) * | 2004-07-23 | 2007-11-15 | Ignagni Anthony R | Ventilatory assist system and methods to improve respiratory function |
US20080004668A1 (en) * | 2004-08-09 | 2008-01-03 | Cardiac Pacemakers, Inc. | Cardiopulmonary functional status assessment via heart rate response dectection by implantable cardiac device |
US20080109047A1 (en) * | 2006-10-26 | 2008-05-08 | Pless Benjamin D | Apnea treatment device |
US20080114410A1 (en) * | 2005-05-25 | 2008-05-15 | Cardiac Pacemakers, Inc. | Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods |
US20080154330A1 (en) * | 2006-12-22 | 2008-06-26 | Tehrani Amir J | Device and method to treat flow limitations |
US20080167695A1 (en) * | 2003-10-15 | 2008-07-10 | Tehrani Amir J | Therapeutic diaphragm stimulation device and method |
US20080188867A1 (en) * | 2007-02-05 | 2008-08-07 | Ignagni Anthony R | Removable intramuscular electrode |
US20080188904A1 (en) * | 2003-10-15 | 2008-08-07 | Tehrani Amir J | Device and method for treating disorders of the cardiovascular system or heart |
US20080208282A1 (en) * | 2007-01-22 | 2008-08-28 | Mark Gelfand | Device and method for the treatment of breathing disorders and cardiac disorders |
US20080234556A1 (en) * | 2007-03-20 | 2008-09-25 | Cardiac Pacemakers, Inc. | Method and apparatus for sensing respiratory activities using sensor in lymphatic system |
US20080269625A1 (en) * | 2004-02-05 | 2008-10-30 | Earlysense Ltd. | Prediction and monitoring of clinical episodes |
US20080287820A1 (en) * | 2007-05-17 | 2008-11-20 | Synapse Biomedical, Inc. | Devices and methods for assessing motor point electromyogram as a biomarker |
US20090062882A1 (en) * | 2007-08-28 | 2009-03-05 | Cardiac Pacemakers, Inc. | Method and apparatus for inspiratory muscle stimulation using implantable device |
US20090099621A1 (en) * | 2007-10-10 | 2009-04-16 | Zheng Lin | Respiratory stimulation for treating periodic breathing |
US20090118785A1 (en) * | 2007-10-30 | 2009-05-07 | Ignagni Anthony R | Method of improving sleep disordered breathing |
US20090192394A1 (en) * | 2008-01-16 | 2009-07-30 | Guttag John V | Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal |
WO2009114548A1 (en) * | 2008-03-12 | 2009-09-17 | Corventis, Inc. | Heart failure decompensation prediction based on cardiac rhythm |
US20100016748A1 (en) * | 2008-07-17 | 2010-01-21 | Syed Zeeshan H | Motif Discovery in Physiological Datasets: A Methodology for Inferring Predictive Elements |
US20100076324A1 (en) * | 2008-09-19 | 2010-03-25 | Cho Yong K | Method and apparatus for detecting respiratory effort in a medical device |
US7704211B1 (en) * | 2005-03-21 | 2010-04-27 | Pacesetter, Inc. | Method and apparatus for assessing fluid level in lungs |
US20100160992A1 (en) * | 2007-05-28 | 2010-06-24 | St. Jude Medical Ab | Implantable medical device, system and method |
US20100228133A1 (en) * | 2005-09-16 | 2010-09-09 | Averina Viktoria A | System and Method for Generating a Trend Parameter Based on Respiration Rate Distribution |
US20110054279A1 (en) * | 2008-03-27 | 2011-03-03 | Widemed Ltd. | Diagnosis of periodic breathing |
US20110060380A1 (en) * | 2009-09-10 | 2011-03-10 | Mark Gelfand | Respiratory rectification |
US20110060381A1 (en) * | 2003-07-23 | 2011-03-10 | Ignagni Anthony R | System and Method for Conditioning a Diaphragm of a Patient |
US7917194B1 (en) * | 2006-11-15 | 2011-03-29 | Pacesetter, Inc. | Method and apparatus for detecting pulmonary edema |
US20110230932A1 (en) * | 2003-10-15 | 2011-09-22 | Rmx, Llc | Device and method for independently stimulating hemidiaphragms |
US8116841B2 (en) | 2007-09-14 | 2012-02-14 | Corventis, Inc. | Adherent device with multiple physiological sensors |
US20120157799A1 (en) * | 2010-12-20 | 2012-06-21 | Abhilash Patangay | Using device based sensors to classify events and generate alerts |
US8244358B2 (en) | 2003-10-15 | 2012-08-14 | Rmx, Llc | Device and method for treating obstructive sleep apnea |
US8249686B2 (en) | 2007-09-14 | 2012-08-21 | Corventis, Inc. | Adherent device for sleep disordered breathing |
US8374688B2 (en) | 2007-09-14 | 2013-02-12 | Corventis, Inc. | System and methods for wireless body fluid monitoring |
US8376954B2 (en) | 2004-02-05 | 2013-02-19 | Earlysense Ltd. | Techniques for prediction and monitoring of respiration-manifested clinical episodes |
US8412317B2 (en) | 2008-04-18 | 2013-04-02 | Corventis, Inc. | Method and apparatus to measure bioelectric impedance of patient tissue |
US8428726B2 (en) | 2007-10-30 | 2013-04-23 | Synapse Biomedical, Inc. | Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system |
US8433412B1 (en) | 2008-02-07 | 2013-04-30 | Respicardia, Inc. | Muscle and nerve stimulation |
US8460189B2 (en) | 2007-09-14 | 2013-06-11 | Corventis, Inc. | Adherent cardiac monitor with advanced sensing capabilities |
US8491492B2 (en) | 2004-02-05 | 2013-07-23 | Earlysense Ltd. | Monitoring a condition of a subject |
US20130197385A1 (en) * | 2012-01-31 | 2013-08-01 | Medtronic, Inc. | Respiratory function detection |
US8509902B2 (en) | 2011-07-28 | 2013-08-13 | Medtronic, Inc. | Medical device to provide breathing therapy |
US8538525B2 (en) | 2004-08-12 | 2013-09-17 | Cardiac Pacemakers, Inc. | Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device |
US8585607B2 (en) | 2007-05-02 | 2013-11-19 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US8585604B2 (en) | 2010-10-29 | 2013-11-19 | Medtronic, Inc. | Integrated patient care |
US20140031643A1 (en) * | 2012-07-27 | 2014-01-30 | Cardiac Pacemakers, Inc. | Heart failure patients stratification |
US8684925B2 (en) | 2007-09-14 | 2014-04-01 | Corventis, Inc. | Injectable device for physiological monitoring |
CN103800999A (en) * | 2014-02-25 | 2014-05-21 | 郑州雅晨生物科技有限公司 | Obstructive sleep apnea hypopnea syndrome therapeutic apparatus |
US8790259B2 (en) | 2009-10-22 | 2014-07-29 | Corventis, Inc. | Method and apparatus for remote detection and monitoring of functional chronotropic incompetence |
US8821418B2 (en) | 2007-05-02 | 2014-09-02 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US8823490B2 (en) | 2008-12-15 | 2014-09-02 | Corventis, Inc. | Patient monitoring systems and methods |
US8882684B2 (en) | 2008-05-12 | 2014-11-11 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US8897868B2 (en) | 2007-09-14 | 2014-11-25 | Medtronic, Inc. | Medical device automatic start-up upon contact to patient tissue |
US8942779B2 (en) | 2004-02-05 | 2015-01-27 | Early Sense Ltd. | Monitoring a condition of a subject |
US8965498B2 (en) | 2010-04-05 | 2015-02-24 | Corventis, Inc. | Method and apparatus for personalized physiologic parameters |
US20150057555A1 (en) * | 2013-08-20 | 2015-02-26 | Sorin Crm Sas | Systems and methods for diagnosing heart failure based on sleep apneic indicators |
WO2016013684A1 (en) * | 2014-07-22 | 2016-01-28 | 帝人ファーマ株式会社 | Heart failure evaluation method and diagnosis device |
US9295397B2 (en) | 2013-06-14 | 2016-03-29 | Massachusetts Institute Of Technology | Method and apparatus for beat-space frequency domain prediction of cardiovascular death after acute coronary event |
US9411936B2 (en) | 2007-09-14 | 2016-08-09 | Medtronic Monitoring, Inc. | Dynamic pairing of patients to data collection gateways |
US9451897B2 (en) | 2009-12-14 | 2016-09-27 | Medtronic Monitoring, Inc. | Body adherent patch with electronics for physiologic monitoring |
US20170112409A1 (en) * | 2013-02-06 | 2017-04-27 | BTS S.p.A. | Wireless probe for dental electromyography |
US9743889B2 (en) | 2013-08-05 | 2017-08-29 | Cardiac Pacemakers, Inc. | System and method for detecting worsening of heart failure based on rapid shallow breathing index |
US9839781B2 (en) | 2005-08-22 | 2017-12-12 | Cardiac Pacemakers, Inc. | Intracardiac impedance and its applications |
US9861817B2 (en) | 2011-07-28 | 2018-01-09 | Medtronic, Inc. | Medical device to provide breathing therapy |
US9883809B2 (en) | 2008-05-01 | 2018-02-06 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US9968266B2 (en) | 2006-12-27 | 2018-05-15 | Cardiac Pacemakers, Inc. | Risk stratification based heart failure detection algorithm |
US9987488B1 (en) | 2007-06-27 | 2018-06-05 | Respicardia, Inc. | Detecting and treating disordered breathing |
US20180235503A1 (en) * | 2015-08-11 | 2018-08-23 | Koninklijke Philips N.V. | Apparatus and method for processing electromyography signals related to respiratory activity |
US10292625B2 (en) | 2010-12-07 | 2019-05-21 | Earlysense Ltd. | Monitoring a sleeping subject |
US10406366B2 (en) | 2006-11-17 | 2019-09-10 | Respicardia, Inc. | Transvenous phrenic nerve stimulation system |
WO2019189153A1 (en) * | 2018-03-26 | 2019-10-03 | テルモ株式会社 | Support system, support method, support program, and recording medium on which support program is recorded |
US10857363B2 (en) | 2014-08-26 | 2020-12-08 | Rmx, Llc | Devices and methods for reducing intrathoracic pressure |
US10894055B2 (en) | 2013-11-06 | 2021-01-19 | Aeromics, Inc. | Pharmaceutical compositions, methods of making pharmaceutical compositions, and kits comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}4-chlorophenyl dihydrogen phosphate |
US11084778B2 (en) * | 2012-05-08 | 2021-08-10 | Aeromics, Inc. | Methods of treating cardiac edema, neuromyelitis optica, and hyponatremia |
US11266838B1 (en) | 2019-06-21 | 2022-03-08 | Rmx, Llc | Airway diagnostics utilizing phrenic nerve stimulation device and method |
CN114376559A (en) * | 2022-01-18 | 2022-04-22 | 高昌生医股份有限公司 | Respiration baseline tracking acceleration method |
US11471683B2 (en) | 2019-01-29 | 2022-10-18 | Synapse Biomedical, Inc. | Systems and methods for treating sleep apnea using neuromodulation |
US11564626B2 (en) | 2019-08-26 | 2023-01-31 | Samsung Electronics Co., Ltd. | Implantable monitoring device and method of operating the implantable monitoring device |
US11615891B2 (en) | 2017-04-29 | 2023-03-28 | Cardiac Pacemakers, Inc. | Heart failure event rate assessment |
US11812936B2 (en) | 2014-09-03 | 2023-11-14 | Hill-Rom Services, Inc. | Apparatus and methods for monitoring a sleeping subject |
Families Citing this family (215)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060161071A1 (en) | 1997-01-27 | 2006-07-20 | Lynn Lawrence A | Time series objectification system and method |
US9042952B2 (en) | 1997-01-27 | 2015-05-26 | Lawrence A. Lynn | System and method for automatic detection of a plurality of SPO2 time series pattern types |
US8932227B2 (en) | 2000-07-28 | 2015-01-13 | Lawrence A. Lynn | System and method for CO2 and oximetry integration |
US6024089A (en) | 1997-03-14 | 2000-02-15 | Nelcor Puritan Bennett Incorporated | System and method for setting and displaying ventilator alarms |
US9521971B2 (en) | 1997-07-14 | 2016-12-20 | Lawrence A. Lynn | System and method for automatic detection of a plurality of SPO2 time series pattern types |
US9053222B2 (en) | 2002-05-17 | 2015-06-09 | Lawrence A. Lynn | Patient safety processor |
US20060195041A1 (en) | 2002-05-17 | 2006-08-31 | Lynn Lawrence A | Centralized hospital monitoring system for automatically detecting upper airway instability and for preventing and aborting adverse drug reactions |
US20080077192A1 (en) | 2002-05-03 | 2008-03-27 | Afferent Corporation | System and method for neuro-stimulation |
DE10248590B4 (en) * | 2002-10-17 | 2016-10-27 | Resmed R&D Germany Gmbh | Method and device for carrying out a signal-processing observation of a measurement signal associated with the respiratory activity of a person |
US7477932B2 (en) | 2003-05-28 | 2009-01-13 | Cardiac Pacemakers, Inc. | Cardiac waveform template creation, maintenance and use |
US7575553B2 (en) * | 2003-09-18 | 2009-08-18 | Cardiac Pacemakers, Inc. | Methods and systems for assessing pulmonary disease |
US7787946B2 (en) | 2003-08-18 | 2010-08-31 | Cardiac Pacemakers, Inc. | Patient monitoring, diagnosis, and/or therapy systems and methods |
US7887493B2 (en) | 2003-09-18 | 2011-02-15 | Cardiac Pacemakers, Inc. | Implantable device employing movement sensing for detecting sleep-related disorders |
US7510531B2 (en) * | 2003-09-18 | 2009-03-31 | Cardiac Pacemakers, Inc. | System and method for discrimination of central and obstructive disordered breathing events |
US20050107838A1 (en) * | 2003-09-18 | 2005-05-19 | Lovett Eric G. | Subcutaneous cardiac rhythm management with disordered breathing detection and treatment |
US7396333B2 (en) | 2003-08-18 | 2008-07-08 | Cardiac Pacemakers, Inc. | Prediction of disordered breathing |
US7662101B2 (en) * | 2003-09-18 | 2010-02-16 | Cardiac Pacemakers, Inc. | Therapy control based on cardiopulmonary status |
US8002553B2 (en) | 2003-08-18 | 2011-08-23 | Cardiac Pacemakers, Inc. | Sleep quality data collection and evaluation |
US20060167523A1 (en) * | 2003-10-15 | 2006-07-27 | Tehrani Amir J | Device and method for improving upper airway functionality |
US20050085874A1 (en) * | 2003-10-17 | 2005-04-21 | Ross Davis | Method and system for treating sleep apnea |
US20060247693A1 (en) | 2005-04-28 | 2006-11-02 | Yanting Dong | Non-captured intrinsic discrimination in cardiac pacing response classification |
US7319900B2 (en) * | 2003-12-11 | 2008-01-15 | Cardiac Pacemakers, Inc. | Cardiac response classification using multiple classification windows |
US8521284B2 (en) | 2003-12-12 | 2013-08-27 | Cardiac Pacemakers, Inc. | Cardiac response classification using multisite sensing and pacing |
US7774064B2 (en) | 2003-12-12 | 2010-08-10 | Cardiac Pacemakers, Inc. | Cardiac response classification using retriggerable classification windows |
US7421296B1 (en) * | 2004-01-26 | 2008-09-02 | Pacesetter, Inc. | Termination of respiratory oscillations characteristic of Cheyne-Stokes respiration |
US7363085B1 (en) * | 2004-01-26 | 2008-04-22 | Pacesetters, Inc. | Augmenting hypoventilation |
US7314451B2 (en) | 2005-04-25 | 2008-01-01 | Earlysense Ltd. | Techniques for prediction and monitoring of clinical episodes |
US7751894B1 (en) * | 2004-03-04 | 2010-07-06 | Cardiac Pacemakers, Inc. | Systems and methods for indicating aberrant behavior detected by an implanted medical device |
US20050197588A1 (en) * | 2004-03-04 | 2005-09-08 | Scott Freeberg | Sleep disordered breathing alert system |
US7371220B1 (en) * | 2004-06-30 | 2008-05-13 | Pacesetter, Inc. | System and method for real-time apnea/hypopnea detection using an implantable medical system |
US20090216293A1 (en) * | 2004-11-22 | 2009-08-27 | Mitsuru Sasaki | Apnea preventing stimulation apparatus |
US8473058B2 (en) * | 2004-11-22 | 2013-06-25 | Mitsuru Sasaki | Apnea preventing stimulation apparatus |
US20060122661A1 (en) * | 2004-12-03 | 2006-06-08 | Mandell Lee J | Diaphragmatic pacing with activity monitor adjustment |
US7966072B2 (en) * | 2005-02-18 | 2011-06-21 | Palo Alto Investors | Methods and compositions for treating obesity-hypoventilation syndrome |
US7680534B2 (en) | 2005-02-28 | 2010-03-16 | Cardiac Pacemakers, Inc. | Implantable cardiac device with dyspnea measurement |
US7404799B1 (en) * | 2005-04-05 | 2008-07-29 | Pacesetter, Inc. | System and method for detection of respiration patterns via integration of intracardiac electrogram signals |
US7392086B2 (en) | 2005-04-26 | 2008-06-24 | Cardiac Pacemakers, Inc. | Implantable cardiac device and method for reduced phrenic nerve stimulation |
US7499751B2 (en) * | 2005-04-28 | 2009-03-03 | Cardiac Pacemakers, Inc. | Cardiac signal template generation using waveform clustering |
US8900154B2 (en) * | 2005-05-24 | 2014-12-02 | Cardiac Pacemakers, Inc. | Prediction of thoracic fluid accumulation |
US7644714B2 (en) | 2005-05-27 | 2010-01-12 | Apnex Medical, Inc. | Devices and methods for treating sleep disorders |
US8364455B2 (en) * | 2005-06-09 | 2013-01-29 | Maquet Critical Care Ab | Simulator for use with a breathing-assist device |
US8036750B2 (en) | 2005-06-13 | 2011-10-11 | Cardiac Pacemakers, Inc. | System for neural control of respiration |
JP2009515174A (en) * | 2005-11-04 | 2009-04-09 | レスメド・リミテッド | Method and apparatus for supporting diagnosis and management of sleep breathing disorders |
EP1960040B1 (en) * | 2005-12-01 | 2017-02-08 | Second Sight Medical Products, Inc. | Fitting a neural prosthesis using impedance and electrode height |
US7766840B2 (en) * | 2005-12-01 | 2010-08-03 | Cardiac Pacemakers, Inc. | Method and system for heart failure status evaluation based on a disordered breathing index |
US8281792B2 (en) * | 2005-12-31 | 2012-10-09 | John W Royalty | Electromagnetic diaphragm assist device and method for assisting a diaphragm function |
WO2007115118A1 (en) * | 2006-03-29 | 2007-10-11 | Catholic Healthcare West | Vagus nerve stimulation method |
US8021310B2 (en) | 2006-04-21 | 2011-09-20 | Nellcor Puritan Bennett Llc | Work of breathing display for a ventilation system |
WO2007136266A1 (en) * | 2006-05-23 | 2007-11-29 | Publiekrechtelijke Rechtspersoon Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Ce | Medical probe |
KR100845464B1 (en) * | 2006-06-14 | 2008-07-10 | (주)머티리얼솔루션테크놀로지 | Implantable diaphragm stimulator and breathing pacemaker using the same |
US20080071185A1 (en) * | 2006-08-08 | 2008-03-20 | Cardiac Pacemakers, Inc. | Periodic breathing during activity |
US8226570B2 (en) | 2006-08-08 | 2012-07-24 | Cardiac Pacemakers, Inc. | Respiration monitoring for heart failure using implantable device |
US8103341B2 (en) | 2006-08-25 | 2012-01-24 | Cardiac Pacemakers, Inc. | System for abating neural stimulation side effects |
US8121692B2 (en) | 2006-08-30 | 2012-02-21 | Cardiac Pacemakers, Inc. | Method and apparatus for neural stimulation with respiratory feedback |
US8050765B2 (en) | 2006-08-30 | 2011-11-01 | Cardiac Pacemakers, Inc. | Method and apparatus for controlling neural stimulation during disordered breathing |
JP5236647B2 (en) * | 2006-09-11 | 2013-07-17 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | System and method for electrode placement on patient body |
US8209013B2 (en) | 2006-09-14 | 2012-06-26 | Cardiac Pacemakers, Inc. | Therapeutic electrical stimulation that avoids undesirable activation |
US7784461B2 (en) | 2006-09-26 | 2010-08-31 | Nellcor Puritan Bennett Llc | Three-dimensional waveform display for a breathing assistance system |
US20080072902A1 (en) * | 2006-09-27 | 2008-03-27 | Nellcor Puritan Bennett Incorporated | Preset breath delivery therapies for a breathing assistance system |
AU2007313319B2 (en) | 2006-10-13 | 2012-03-22 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US9186511B2 (en) | 2006-10-13 | 2015-11-17 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US9913982B2 (en) | 2011-01-28 | 2018-03-13 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US9205262B2 (en) | 2011-05-12 | 2015-12-08 | Cyberonics, Inc. | Devices and methods for sleep apnea treatment |
US9744354B2 (en) | 2008-12-31 | 2017-08-29 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8855771B2 (en) | 2011-01-28 | 2014-10-07 | Cyberonics, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
CA2877177C (en) | 2007-01-29 | 2018-05-22 | Simon Fraser University | Transvascular nerve stimulation apparatus and methods |
US8417328B2 (en) * | 2007-02-01 | 2013-04-09 | Ls Biopath, Inc. | Electrical systems for detection and characterization of abnormal tissue and cells |
EP2174118A4 (en) * | 2007-02-01 | 2015-06-24 | Ls Biopath Inc | Optical system for identification and characterization of abnormal tissue and cells |
WO2008123903A1 (en) * | 2007-02-09 | 2008-10-16 | Mayo Foundation For Medical Education And Research | Peripheral oxistimulator apparatus and methods |
US20080228093A1 (en) * | 2007-03-13 | 2008-09-18 | Yanting Dong | Systems and methods for enhancing cardiac signal features used in morphology discrimination |
US20080243016A1 (en) * | 2007-03-28 | 2008-10-02 | Cardiac Pacemakers, Inc. | Pulmonary Artery Pressure Signals And Methods of Using |
US11259802B2 (en) * | 2007-04-13 | 2022-03-01 | Covidien Lp | Powered surgical instrument |
US7950560B2 (en) * | 2007-04-13 | 2011-05-31 | Tyco Healthcare Group Lp | Powered surgical instrument |
US8983609B2 (en) | 2007-05-30 | 2015-03-17 | The Cleveland Clinic Foundation | Apparatus and method for treating pulmonary conditions |
US20090024176A1 (en) * | 2007-07-17 | 2009-01-22 | Joonkyoo Anthony Yun | Methods and devices for producing respiratory sinus arrhythmia |
US20090024047A1 (en) * | 2007-07-20 | 2009-01-22 | Cardiac Pacemakers, Inc. | Devices and methods for respiration therapy |
US9037239B2 (en) | 2007-08-07 | 2015-05-19 | Cardiac Pacemakers, Inc. | Method and apparatus to perform electrode combination selection |
US8265736B2 (en) | 2007-08-07 | 2012-09-11 | Cardiac Pacemakers, Inc. | Method and apparatus to perform electrode combination selection |
EP2210639A3 (en) * | 2007-08-22 | 2014-08-06 | The Research Foundation Of State University Of New York | Breathing-gas delivery and sharing system |
EP2210226A4 (en) * | 2007-10-12 | 2013-11-06 | Patientslikeme Inc | Self-improving method of using online communities to predict health-related outcomes |
US20170188940A9 (en) | 2007-11-26 | 2017-07-06 | Whispersom Corporation | Device to detect and treat Apneas and Hypopnea |
US8155744B2 (en) | 2007-12-13 | 2012-04-10 | The Cleveland Clinic Foundation | Neuromodulatory methods for treating pulmonary disorders |
EP2254661B1 (en) | 2008-02-14 | 2015-10-07 | Cardiac Pacemakers, Inc. | Apparatus for phrenic stimulation detection |
JP5474937B2 (en) | 2008-05-07 | 2014-04-16 | ローレンス エー. リン, | Medical disorder pattern search engine |
EP3708219B1 (en) | 2008-05-15 | 2022-08-03 | Inspire Medical Systems, Inc. | Apparatus for sensing respiratory pressure in an implantable stimulation system |
US8229566B2 (en) * | 2008-06-25 | 2012-07-24 | Sheng Li | Method and apparatus of breathing-controlled electrical stimulation for skeletal muscles |
US8302602B2 (en) | 2008-09-30 | 2012-11-06 | Nellcor Puritan Bennett Llc | Breathing assistance system with multiple pressure sensors |
EP2331201B1 (en) | 2008-10-01 | 2020-04-29 | Inspire Medical Systems, Inc. | System for treating sleep apnea transvenously |
US20100087893A1 (en) * | 2008-10-03 | 2010-04-08 | Solange Pasquet | Operant Conditioning-Based Device for Snoring and Obstructive Sleep Apnea and Method of Use |
US8644939B2 (en) * | 2008-11-18 | 2014-02-04 | Neurostream Technologies General Partnership | Method and device for the detection, identification and treatment of sleep apnea/hypopnea |
EP3184045B1 (en) * | 2008-11-19 | 2023-12-06 | Inspire Medical Systems, Inc. | System treating sleep disordered breathing |
EP2198779B1 (en) * | 2008-12-22 | 2018-09-19 | Sendsor GmbH | Device and method for early detection of exacerbations |
US20100204567A1 (en) * | 2009-02-09 | 2010-08-12 | The Cleveland Clinic Foundation | Ultrasound-guided delivery of a therapy delivery device to a phrenic nerve |
US8870773B2 (en) * | 2009-02-09 | 2014-10-28 | The Cleveland Clinic Foundation | Ultrasound-guided delivery of a therapy delivery device to a nerve target |
US9486628B2 (en) | 2009-03-31 | 2016-11-08 | Inspire Medical Systems, Inc. | Percutaneous access for systems and methods of treating sleep apnea |
AU2010242036A1 (en) | 2009-04-30 | 2011-11-03 | Patientslikeme, Inc. | Systems and methods for encouragement of data submission in online communities |
US8378832B2 (en) * | 2009-07-09 | 2013-02-19 | Harry J. Cassidy | Breathing disorder treatment system and method |
WO2011008748A2 (en) | 2009-07-15 | 2011-01-20 | Cardiac Pacemakers, Inc. | Remote pace detection in an implantable medical device |
EP2453975B1 (en) | 2009-07-15 | 2016-11-02 | Cardiac Pacemakers, Inc. | Remote sensing in an implantable medical device |
EP2453977B1 (en) * | 2009-07-15 | 2017-11-08 | Cardiac Pacemakers, Inc. | Physiological vibration detection in an implanted medical device |
EP2470065A1 (en) * | 2009-08-28 | 2012-07-04 | Lynn, Lawrence Allan | Relational thermorespirometer spot vitals monitor |
US9072899B1 (en) * | 2009-09-04 | 2015-07-07 | Todd Nickloes | Diaphragm pacemaker |
AU2010291938B2 (en) * | 2009-09-14 | 2016-03-10 | Sleep Methods, Inc. | System and method for training and promoting a conditioned reflex intervention during sleep |
US8409108B2 (en) * | 2009-11-05 | 2013-04-02 | Inovise Medical, Inc. | Multi-axial heart sounds and murmur detection for hemodynamic-condition assessment |
USD638852S1 (en) | 2009-12-04 | 2011-05-31 | Nellcor Puritan Bennett Llc | Ventilator display screen with an alarm icon |
USD649157S1 (en) | 2009-12-04 | 2011-11-22 | Nellcor Puritan Bennett Llc | Ventilator display screen with a user interface |
US9119925B2 (en) | 2009-12-04 | 2015-09-01 | Covidien Lp | Quick initiation of respiratory support via a ventilator user interface |
US8924878B2 (en) | 2009-12-04 | 2014-12-30 | Covidien Lp | Display and access to settings on a ventilator graphical user interface |
US8335992B2 (en) | 2009-12-04 | 2012-12-18 | Nellcor Puritan Bennett Llc | Visual indication of settings changes on a ventilator graphical user interface |
US9262588B2 (en) | 2009-12-18 | 2016-02-16 | Covidien Lp | Display of respiratory data graphs on a ventilator graphical user interface |
US8499252B2 (en) | 2009-12-18 | 2013-07-30 | Covidien Lp | Display of respiratory data graphs on a ventilator graphical user interface |
JP2011213096A (en) * | 2010-03-19 | 2011-10-27 | Makita Corp | Power tool |
US11723542B2 (en) * | 2010-08-13 | 2023-08-15 | Respiratory Motion, Inc. | Advanced respiratory monitor and system |
US8983572B2 (en) | 2010-10-29 | 2015-03-17 | Inspire Medical Systems, Inc. | System and method for patient selection in treating sleep disordered breathing |
KR20120046554A (en) * | 2010-11-02 | 2012-05-10 | 연세대학교 산학협력단 | Sensor for detecting cancer tissue and manufacturing method of the same |
US9186504B2 (en) | 2010-11-15 | 2015-11-17 | Rainbow Medical Ltd | Sleep apnea treatment |
US9457186B2 (en) | 2010-11-15 | 2016-10-04 | Bluewind Medical Ltd. | Bilateral feedback |
CN103221086B (en) * | 2010-11-23 | 2015-11-25 | 皇家飞利浦电子股份有限公司 | Fat hypoventilation syndrome disposal system |
US8827930B2 (en) * | 2011-01-10 | 2014-09-09 | Bioguidance Llc | System and method for patient monitoring |
US9744349B2 (en) | 2011-02-10 | 2017-08-29 | Respicardia, Inc. | Medical lead and implantation |
US10342939B2 (en) * | 2011-03-23 | 2019-07-09 | ResMed Pty Ltd | Detection of ventilation sufficiency |
EP2713870A4 (en) * | 2011-06-03 | 2014-10-22 | Los Angeles Childrens Hospital | Electrophysiological diagnosis and treatment for asthma |
US8706235B2 (en) | 2011-07-27 | 2014-04-22 | Medtronic, Inc. | Transvenous method to induce respiration |
US8478413B2 (en) | 2011-07-27 | 2013-07-02 | Medtronic, Inc. | Bilateral phrenic nerve stimulation with reduced dyssynchrony |
JP6092212B2 (en) | 2011-08-11 | 2017-03-08 | インスパイア・メディカル・システムズ・インコーポレイテッドInspire Medical Systems, Inc. | System for selecting a stimulation protocol based on detection results of respiratory effort |
US20130053717A1 (en) * | 2011-08-30 | 2013-02-28 | Nellcor Puritan Bennett Llc | Automatic ventilator challenge to induce spontaneous breathing efforts |
US8934992B2 (en) | 2011-09-01 | 2015-01-13 | Inspire Medical Systems, Inc. | Nerve cuff |
US8855783B2 (en) | 2011-09-09 | 2014-10-07 | Enopace Biomedical Ltd. | Detector-based arterial stimulation |
GB201116860D0 (en) * | 2011-09-30 | 2011-11-09 | Guy S And St Thomas Nhs Foundation Trust | Patent monitoring method and monitoring device |
US9364624B2 (en) | 2011-12-07 | 2016-06-14 | Covidien Lp | Methods and systems for adaptive base flow |
US9498589B2 (en) | 2011-12-31 | 2016-11-22 | Covidien Lp | Methods and systems for adaptive base flow and leak compensation |
CN104508343B (en) | 2012-01-26 | 2016-11-16 | Med-El电气医疗器械有限公司 | For treating the Neural monitoring method and system of pharyngeal obstacle |
WO2013112853A1 (en) * | 2012-01-27 | 2013-08-01 | T4 Analytics Llc | Anesthesia monitoring systems and methods of monitoring anesthesia |
EP2822645B1 (en) | 2012-03-05 | 2017-05-03 | Simon Fraser University | Transvascular nerve stimulation apparatus |
US8844526B2 (en) | 2012-03-30 | 2014-09-30 | Covidien Lp | Methods and systems for triggering with unknown base flow |
EP4233953A3 (en) | 2012-06-21 | 2023-11-01 | Lungpacer Medical Inc. | Transvascular diaphragm pacing systems |
US20150165207A1 (en) * | 2012-07-02 | 2015-06-18 | Medisci L.L.C. | Method and device for respiratory and cardiorespiratory support |
US10362967B2 (en) | 2012-07-09 | 2019-07-30 | Covidien Lp | Systems and methods for missed breath detection and indication |
CN102949770B (en) * | 2012-11-09 | 2015-04-22 | 张红璇 | External diaphragm pacing and breathing machine synergistic air supply method and device thereof |
WO2014099820A1 (en) * | 2012-12-19 | 2014-06-26 | Inovise Medical, Inc. | Hemodynamic performance enhancement through asymptomatic diaphragm stimulation |
US10335592B2 (en) | 2012-12-19 | 2019-07-02 | Viscardia, Inc. | Systems, devices, and methods for improving hemodynamic performance through asymptomatic diaphragm stimulation |
CN103055417B (en) * | 2012-12-31 | 2015-09-09 | 中国人民解放军第三军医大学第一附属医院 | A kind of noinvasive transcutaneous electrostimulation instrument |
US9981096B2 (en) | 2013-03-13 | 2018-05-29 | Covidien Lp | Methods and systems for triggering with unknown inspiratory flow |
TWI505812B (en) * | 2013-04-15 | 2015-11-01 | Chi Mei Comm Systems Inc | System and method for displaying analysis of breath |
WO2015021348A2 (en) | 2013-08-09 | 2015-02-12 | Inspire Medical Systems, Inc. | Patient control for implantable medical device |
KR20160067152A (en) * | 2013-10-02 | 2016-06-13 | 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 | Organ mounted electronics |
WO2015069949A1 (en) | 2013-11-07 | 2015-05-14 | Safeop Surgical, Inc. | Systems and methods for detecting nerve function |
EP3071288B1 (en) | 2013-11-19 | 2018-11-14 | The Cleveland Clinic Foundation | System for treating obstructive sleep apnea using a neuromuscular stimulator |
CN105873630B (en) | 2013-11-22 | 2020-01-03 | 隆佩瑟尔医疗公司 | Device and method for assisted respiration by transvascular nerve stimulation |
WO2015095969A1 (en) * | 2013-12-27 | 2015-07-02 | St. Michael's Hospital | Device, method and system for providing ventilatory assist to a patient |
WO2015109401A1 (en) * | 2014-01-21 | 2015-07-30 | Simon Fraser University | Systems and related methods for optimization of multi-electrode nerve pacing |
EP4241662A1 (en) | 2014-02-11 | 2023-09-13 | Cyberonics, Inc. | Systems for detecting and treating obstructive sleep apnea |
TWI645835B (en) | 2014-02-25 | 2019-01-01 | 萊鎂醫療器材股份有限公司 | Breathing airflow detecting device, method and application thereof |
JP6585609B2 (en) * | 2014-02-28 | 2019-10-02 | パウエル マンスフィールド, インコーポレイテッド | System for sensing EMG activity |
US20150283382A1 (en) * | 2014-04-04 | 2015-10-08 | Med-El Elektromedizinische Geraete Gmbh | Respiration Sensors For Recording Of Triggered Respiratory Signals In Neurostimulators |
US9659159B2 (en) | 2014-08-14 | 2017-05-23 | Sleep Data Services, Llc | Sleep data chain of custody |
US9808591B2 (en) | 2014-08-15 | 2017-11-07 | Covidien Lp | Methods and systems for breath delivery synchronization |
KR102410215B1 (en) * | 2014-10-08 | 2022-06-17 | 엘지전자 주식회사 | Digital device and method for controlling same |
CN106999118B (en) | 2014-10-13 | 2020-07-17 | 葡萄糖传感器公司 | Analyte sensing device |
US9950129B2 (en) | 2014-10-27 | 2018-04-24 | Covidien Lp | Ventilation triggering using change-point detection |
CA2966197C (en) | 2014-10-31 | 2023-04-11 | Avent, Inc. | Non-invasive nerve stimulation system and method |
US9925346B2 (en) | 2015-01-20 | 2018-03-27 | Covidien Lp | Systems and methods for ventilation with unknown exhalation flow |
EP3064131A1 (en) * | 2015-03-03 | 2016-09-07 | BIOTRONIK SE & Co. KG | Combined vagus-phrenic nerve stimulation apparatus |
EP3881892A1 (en) | 2015-03-19 | 2021-09-22 | Inspire Medical Systems, Inc. | Stimulation for treating sleep disordered breathing |
US9839786B2 (en) | 2015-04-17 | 2017-12-12 | Inspire Medical Systems, Inc. | System and method of monitoring for and reporting on patient-made stimulation therapy programming changes |
EP3405103B1 (en) * | 2016-01-20 | 2021-10-27 | Soniphi LLC | Frequency analysis feedback system |
EP3445872A1 (en) | 2016-04-20 | 2019-02-27 | Glusense Ltd. | Fret-based glucose-detection molecules |
CN105748069B (en) * | 2016-04-21 | 2018-10-23 | 罗远明 | A kind of centric sleep apnea carbon dioxide inhalation therapy device |
CN105879223B (en) * | 2016-04-22 | 2017-02-08 | 广州雪利昂生物科技有限公司 | Method and apparatus for triggering external diaphragm pacemaker by using surface electromyogram signal as synchronization signal |
US10369361B2 (en) | 2016-04-29 | 2019-08-06 | Viscardia, Inc. | Leads for implantable medical device that affects pressures within the intrathoracic cavity through diaphragmatic stimulation |
US11247039B2 (en) | 2016-05-03 | 2022-02-15 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
US10583287B2 (en) | 2016-05-23 | 2020-03-10 | Btl Medical Technologies S.R.O. | Systems and methods for tissue treatment |
US10556122B1 (en) | 2016-07-01 | 2020-02-11 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
WO2018022658A1 (en) * | 2016-07-25 | 2018-02-01 | Ctrl-Labs Corporation | Adaptive system for deriving control signals from measurements of neuromuscular activity |
US11399770B2 (en) | 2016-08-01 | 2022-08-02 | Med-El Elektromedizinische Geraete Gmbh | Respiratory triggered parasternal electromyographic recording in neurostimulators |
US11052241B2 (en) * | 2016-11-03 | 2021-07-06 | West Affum Holdings Corp. | Wearable cardioverter defibrillator (WCD) system measuring patient's respiration |
CN110325110B (en) | 2016-11-10 | 2022-08-09 | 纽约州立大学研究基金会 | Systems, methods, and biomarkers for airway obstruction |
US11426513B2 (en) * | 2016-11-29 | 2022-08-30 | Geoffrey Louis Tyson | Implantable devices for drug delivery in response to detected biometric parameters associated with an opioid drug overdose and associated systems and methods |
CN107019495B (en) * | 2017-03-13 | 2019-11-29 | 北京航空航天大学 | Apnea detection and prior-warning device and method based on smart phone and the mounted respiration transducer of nose |
JP7187473B2 (en) | 2017-03-22 | 2022-12-12 | セーフオプ サージカル インコーポレイテッド | Medical system and method for detecting changes in electrophysiological evoked potentials |
US10293164B2 (en) | 2017-05-26 | 2019-05-21 | Lungpacer Medical Inc. | Apparatus and methods for assisted breathing by transvascular nerve stimulation |
EP3760280A1 (en) * | 2017-06-16 | 2021-01-06 | Alphatec Spine, Inc. | Systems, methods, and devices for detecting the threshold of nerve-muscle response using variable frequency stimulation |
WO2019006239A1 (en) | 2017-06-30 | 2019-01-03 | Lungpacer Medical Inc. | Devices for prevention, moderation, and/or treatment of cognitive injury |
US10195429B1 (en) | 2017-08-02 | 2019-02-05 | Lungpacer Medical Inc. | Systems and methods for intravascular catheter positioning and/or nerve stimulation |
US10940308B2 (en) | 2017-08-04 | 2021-03-09 | Lungpacer Medical Inc. | Systems and methods for trans-esophageal sympathetic ganglion recruitment |
EP3664889B1 (en) | 2017-08-11 | 2024-02-21 | Inspire Medical Systems, Inc. | Cuff electrode |
WO2019046547A1 (en) | 2017-08-31 | 2019-03-07 | Mayo Foundation For Medical Education And Research | Systems and methods for controlling breathing |
CN108174034A (en) * | 2017-12-27 | 2018-06-15 | 苏鹏霄 | Using the system and method for APP real time monitoring sacral nerve neuromodulation devices |
US11031134B2 (en) * | 2018-02-05 | 2021-06-08 | International Business Machines Corporation | Monitoring individuals for water retention management |
US10722710B2 (en) | 2018-03-24 | 2020-07-28 | Moshe Hayik | Secretion clearance and cough assist |
US11058349B2 (en) | 2018-03-24 | 2021-07-13 | Ovadia Sagiv | Non-invasive handling of sleep apnea, snoring and emergency situations |
US11109787B2 (en) * | 2018-05-21 | 2021-09-07 | Vine Medical LLC | Multi-tip probe for obtaining bioelectrical measurements |
US11771899B2 (en) | 2018-07-10 | 2023-10-03 | The Cleveland Clinic Foundation | System and method for treating obstructive sleep apnea |
EP3877043A4 (en) | 2018-11-08 | 2022-08-24 | Lungpacer Medical Inc. | Stimulation systems and related user interfaces |
US11633560B2 (en) | 2018-11-10 | 2023-04-25 | Novaresp Technologies Inc. | Method and apparatus for continuous management of airway pressure for detection and/or prediction of respiratory failure |
US11894139B1 (en) | 2018-12-03 | 2024-02-06 | Patientslikeme Llc | Disease spectrum classification |
US11382563B2 (en) | 2019-03-01 | 2022-07-12 | Respiration AI, LLC | System and method for detecting ventilatory depression and for prompting a patient to breathe |
US11547307B2 (en) * | 2019-04-29 | 2023-01-10 | Technion Research And Development Foundation Ltd. | Quantification of the respiratory effort from hemodynamic measurements |
US11351380B2 (en) | 2019-05-02 | 2022-06-07 | Xii Medical, Inc. | Implantable stimulation power receiver, systems and methods |
JP2022532375A (en) | 2019-05-16 | 2022-07-14 | ラングペーサー メディカル インコーポレイテッド | Systems and methods for detection and stimulation |
US20200375665A1 (en) * | 2019-05-31 | 2020-12-03 | Canon U.S.A., Inc. | Medical continuum robot and methods thereof |
EP3983057A4 (en) | 2019-06-12 | 2023-07-12 | Lungpacer Medical Inc. | Circuitry for medical stimulation systems |
US11324954B2 (en) | 2019-06-28 | 2022-05-10 | Covidien Lp | Achieving smooth breathing by modified bilateral phrenic nerve pacing |
US11524158B2 (en) | 2019-09-26 | 2022-12-13 | Viscardia, Inc. | Implantable medical systems, devices, and methods for affecting cardiac function through diaphragm stimulation, and for monitoring diaphragmatic health |
US11420061B2 (en) | 2019-10-15 | 2022-08-23 | Xii Medical, Inc. | Biased neuromodulation lead and method of using same |
WO2021141950A1 (en) * | 2020-01-06 | 2021-07-15 | W. L. Gore & Associates, Inc. | Conditioning algorithms for biomarker sensor measurements |
EP4069343A4 (en) * | 2020-02-26 | 2024-02-21 | Novaresp Tech Inc | Method and apparatus for determining and/or predicting sleep and respiratory behaviours for management of airway pressure |
WO2021194874A1 (en) | 2020-03-27 | 2021-09-30 | Viscardia, Inc. | Implantable medical systems, devices and methods for delivering asymptomatic diaphragmatic stimulation |
US11878167B2 (en) | 2020-05-04 | 2024-01-23 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
KR20230000081U (en) | 2020-05-04 | 2023-01-10 | 비티엘 헬쓰케어 테크놀로지스 에이.에스. | Device and method for unattended treatment of patients |
US11672934B2 (en) | 2020-05-12 | 2023-06-13 | Covidien Lp | Remote ventilator adjustment |
US11691010B2 (en) | 2021-01-13 | 2023-07-04 | Xii Medical, Inc. | Systems and methods for improving sleep disordered breathing |
CN116963800A (en) * | 2021-02-24 | 2023-10-27 | 美敦力公司 | Impedance-based electrode selection for sensing or stimulation |
US11896816B2 (en) | 2021-11-03 | 2024-02-13 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
US20240050743A1 (en) * | 2022-08-11 | 2024-02-15 | Stimdia Medical, Inc. | Apparatus and method for diaphragm stimulation |
Citations (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4827935A (en) * | 1986-04-24 | 1989-05-09 | Purdue Research Foundation | Demand electroventilator |
US4830008A (en) * | 1987-04-24 | 1989-05-16 | Meer Jeffrey A | Method and system for treatment of sleep apnea |
US5146918A (en) * | 1991-03-19 | 1992-09-15 | Medtronic, Inc. | Demand apnea control of central and obstructive sleep apnea |
US5211173A (en) * | 1991-01-09 | 1993-05-18 | Medtronic, Inc. | Servo muscle control |
US5215082A (en) * | 1991-04-02 | 1993-06-01 | Medtronic, Inc. | Implantable apnea generator with ramp on generator |
US5233983A (en) * | 1991-09-03 | 1993-08-10 | Medtronic, Inc. | Method and apparatus for apnea patient screening |
US5281219A (en) * | 1990-11-23 | 1994-01-25 | Medtronic, Inc. | Multiple stimulation electrodes |
US5300094A (en) * | 1991-01-09 | 1994-04-05 | Medtronic, Inc. | Servo muscle control |
US5423327A (en) * | 1989-02-21 | 1995-06-13 | Clauson; William L. | Method for automatic stimulation of mammels in response to blood gas analysis |
US5423372A (en) * | 1993-12-27 | 1995-06-13 | Ford Motor Company | Joining sand cores for making castings |
US5483969A (en) * | 1994-09-21 | 1996-01-16 | Medtronic, Inc. | Method and apparatus for providing a respiratory effort waveform for the treatment of obstructive sleep apnea |
US5485851A (en) * | 1994-09-21 | 1996-01-23 | Medtronic, Inc. | Method and apparatus for arousal detection |
US5522862A (en) * | 1994-09-21 | 1996-06-04 | Medtronic, Inc. | Method and apparatus for treating obstructive sleep apnea |
US5524632A (en) * | 1994-01-07 | 1996-06-11 | Medtronic, Inc. | Method for implanting electromyographic sensing electrodes |
US5540732A (en) * | 1994-09-21 | 1996-07-30 | Medtronic, Inc. | Method and apparatus for impedance detecting and treating obstructive airway disorders |
US5540731A (en) * | 1994-09-21 | 1996-07-30 | Medtronic, Inc. | Method and apparatus for pressure detecting and treating obstructive airway disorders |
US5540733A (en) * | 1994-09-21 | 1996-07-30 | Medtronic, Inc. | Method and apparatus for detecting and treating obstructive sleep apnea |
US5546952A (en) * | 1994-09-21 | 1996-08-20 | Medtronic, Inc. | Method and apparatus for detection of a respiratory waveform |
US5549655A (en) * | 1994-09-21 | 1996-08-27 | Medtronic, Inc. | Method and apparatus for synchronized treatment of obstructive sleep apnea |
US5766228A (en) * | 1995-10-13 | 1998-06-16 | Ela Medical S.A. | Enslaved active implantable medical device with reduced power consumption |
US5797923A (en) * | 1997-05-12 | 1998-08-25 | Aiyar; Harish | Electrode delivery instrument |
US5800470A (en) * | 1994-01-07 | 1998-09-01 | Medtronic, Inc. | Respiratory muscle electromyographic rate responsive pacemaker |
US5876353A (en) * | 1997-01-31 | 1999-03-02 | Medtronic, Inc. | Impedance monitor for discerning edema through evaluation of respiratory rate |
US5895360A (en) * | 1996-06-26 | 1999-04-20 | Medtronic, Inc. | Gain control for a periodic signal and method regarding same |
US5911218A (en) * | 1995-04-21 | 1999-06-15 | Dimarco; Anthony Fortunato | Method and apparatus for electrical stimulation of the respiratory muscles to achieve artificial ventilation in a patient |
US5944680A (en) * | 1996-06-26 | 1999-08-31 | Medtronic, Inc. | Respiratory effort detection method and apparatus |
US6021352A (en) * | 1996-06-26 | 2000-02-01 | Medtronic, Inc, | Diagnostic testing methods and apparatus for implantable therapy devices |
US6099479A (en) * | 1996-06-26 | 2000-08-08 | Medtronic, Inc. | Method and apparatus for operating therapy system |
US6212435B1 (en) * | 1998-11-13 | 2001-04-03 | Respironics, Inc. | Intraoral electromuscular stimulation device and method |
US6224562B1 (en) * | 1998-06-11 | 2001-05-01 | Cprx Llc | Methods and devices for performing cardiopulmonary resuscitation |
US6251126B1 (en) * | 1998-04-23 | 2001-06-26 | Medtronic Inc | Method and apparatus for synchronized treatment of obstructive sleep apnea |
US6269269B1 (en) * | 1998-04-23 | 2001-07-31 | Medtronic Inc. | Method and apparatus for synchronized treatment of obstructive sleep apnea |
US6345202B2 (en) * | 1998-08-14 | 2002-02-05 | Advanced Bionics Corporation | Method of treating obstructive sleep apnea using implantable electrodes |
US20020049482A1 (en) * | 2000-06-14 | 2002-04-25 | Willa Fabian | Lifestyle management system |
US6415183B1 (en) * | 1999-12-09 | 2002-07-02 | Cardiac Pacemakers, Inc. | Method and apparatus for diaphragmatic pacing |
US6512949B1 (en) * | 1999-07-12 | 2003-01-28 | Medtronic, Inc. | Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto |
US6527729B1 (en) * | 1999-11-10 | 2003-03-04 | Pacesetter, Inc. | Method for monitoring patient using acoustic sensor |
US6542774B2 (en) * | 1996-04-30 | 2003-04-01 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart |
US6574507B1 (en) * | 1998-07-06 | 2003-06-03 | Ela Medical S.A. | Active implantable medical device for treating sleep apnea syndrome by electrostimulation |
US6572543B1 (en) * | 1996-06-26 | 2003-06-03 | Medtronic, Inc | Sensor, method of sensor implant and system for treatment of respiratory disorders |
US6589188B1 (en) * | 2000-05-05 | 2003-07-08 | Pacesetter, Inc. | Method for monitoring heart failure via respiratory patterns |
US20030127091A1 (en) * | 1999-12-15 | 2003-07-10 | Chang Yung Chi | Scientific respiration for self-health-care |
US6600949B1 (en) * | 1999-11-10 | 2003-07-29 | Pacesetter, Inc. | Method for monitoring heart failure via respiratory patterns |
US20030153956A1 (en) * | 2002-02-14 | 2003-08-14 | Euljoon Park | Cardiac stimulation device including sleep apnea prevention and treatment |
US20030153954A1 (en) * | 2002-02-14 | 2003-08-14 | Euljoon Park | Sleep apnea therapy device using dynamic overdrive pacing |
US20030153955A1 (en) * | 2002-02-14 | 2003-08-14 | Euljoon Park | Cardiac stimulation device including sleep apnea prevention and treatment |
US20040059240A1 (en) * | 2001-04-30 | 2004-03-25 | Medtronic, Inc. | Method and apparatus to detect and treat sleep respiratory events |
US20040077953A1 (en) * | 2002-10-18 | 2004-04-22 | Turcott Robert G. | Hemodynamic analysis |
US6731984B2 (en) * | 2001-06-07 | 2004-05-04 | Medtronic, Inc. | Method for providing a therapy to a patient involving modifying the therapy after detecting an onset of sleep in the patient, and implantable medical device embodying same |
US20040088015A1 (en) * | 2002-10-31 | 2004-05-06 | Casavant David A. | Respiratory nerve stimulation |
US20040111040A1 (en) * | 2002-12-04 | 2004-06-10 | Quan Ni | Detection of disordered breathing |
US6752765B1 (en) * | 1999-12-01 | 2004-06-22 | Medtronic, Inc. | Method and apparatus for monitoring heart rate and abnormal respiration |
US20040122484A1 (en) * | 2002-12-18 | 2004-06-24 | John Hatlestad | Advanced patient management for defining, identifying and using predetermined health-related events |
US20040134496A1 (en) * | 2003-01-10 | 2004-07-15 | Cho Yong K. | Method and apparatus for detecting respiratory disturbances |
US20040138719A1 (en) * | 2003-01-10 | 2004-07-15 | Cho Yong K. | System and method for automatically monitoring and delivering therapy for sleep-related disordered breathing |
US20040176809A1 (en) * | 2001-06-07 | 2004-09-09 | Medtronic, Inc. | Method and apparatus for modifying delivery of a therapy in response to onset of sleep |
US20050021102A1 (en) * | 2003-07-23 | 2005-01-27 | Ignagni Anthony R. | System and method for conditioning a diaphragm of a patient |
US20050039745A1 (en) * | 2003-08-18 | 2005-02-24 | Stahmann Jeffrey E. | Adaptive therapy for disordered breathing |
US20050043772A1 (en) * | 2003-08-18 | 2005-02-24 | Stahmann Jeffrey E. | Therapy triggered by prediction of disordered breathing |
US20050043644A1 (en) * | 2003-08-18 | 2005-02-24 | Stahmann Jeffrey E. | Prediction of disordered breathing |
US20050055060A1 (en) * | 2003-09-05 | 2005-03-10 | Steve Koh | Determination of respiratory characteristics from AV conduction intervals |
US20050061319A1 (en) * | 2003-09-18 | 2005-03-24 | Cardiac Pacemakers, Inc. | Methods and systems for implantably monitoring external breathing therapy |
US20050065563A1 (en) * | 2003-09-23 | 2005-03-24 | Avram Scheiner | Paced ventilation therapy by an implantable cardiac device |
US20050061315A1 (en) * | 2003-09-18 | 2005-03-24 | Kent Lee | Feedback system and method for sleep disordered breathing therapy |
US20050061320A1 (en) * | 2003-09-18 | 2005-03-24 | Cardiac Pacemakers, Inc. | Coordinated use of respiratory and cardiac therapies for sleep disordered breathing |
US20050065567A1 (en) * | 2003-09-18 | 2005-03-24 | Cardiac Pacemakers, Inc. | Therapy control based on cardiopulmonary status |
US20050074741A1 (en) * | 2003-09-18 | 2005-04-07 | Kent Lee | System and method for discrimination of central and obstructive disordered breathing events |
US20050080461A1 (en) * | 2003-09-18 | 2005-04-14 | Stahmann Jeffrey E. | System and method for moderating a therapy delivered during sleep using physiologic data acquired during non-sleep |
US20050076909A1 (en) * | 2003-09-18 | 2005-04-14 | Stahmann Jeffrey E. | Synergistic use of medical devices for detecting medical disorders |
US6881192B1 (en) * | 2002-06-12 | 2005-04-19 | Pacesetter, Inc. | Measurement of sleep apnea duration and evaluation of response therapies using duration metrics |
US20050085869A1 (en) * | 2003-10-15 | 2005-04-21 | Tehrani Amir J. | System and method for mapping diaphragm electrode sites |
US20050101833A1 (en) * | 2003-09-02 | 2005-05-12 | Biotronik Gmbh & Co. Kg | Apparatus for the treatment of sleep apnea |
US20050107860A1 (en) * | 2003-07-23 | 2005-05-19 | Ignagni Anthony R. | Mapping probe system for neuromuscular electrical stimulation apparatus |
US20050115561A1 (en) * | 2003-08-18 | 2005-06-02 | Stahmann Jeffrey E. | Patient monitoring, diagnosis, and/or therapy systems and methods |
US20050119711A1 (en) * | 2003-01-10 | 2005-06-02 | Cho Yong K. | Apparatus and method for monitoring for disordered breathing |
US6908437B2 (en) * | 1999-11-16 | 2005-06-21 | Cardiac Intelligence Corporation | System and method for diagnosing and monitoring congestive heart failure for automated remote patient care |
US20050145246A1 (en) * | 2003-09-18 | 2005-07-07 | Hartley Jesse W. | Posture detection system and method |
US20050148897A1 (en) * | 2003-12-24 | 2005-07-07 | Cho Yong K. | Implantable medical device with sleep disordered breathing monitoring |
US20050165457A1 (en) * | 2004-01-26 | 2005-07-28 | Michael Benser | Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration |
US20060058852A1 (en) * | 2004-09-10 | 2006-03-16 | Steve Koh | Multi-variable feedback control of stimulation for inspiratory facilitation |
US20060064030A1 (en) * | 1999-04-16 | 2006-03-23 | Cosentino Daniel L | System, method, and apparatus for combining information from an implanted device with information from a patient monitoring apparatus |
US20060064325A1 (en) * | 2002-10-02 | 2006-03-23 | Suzuken Co., Ltd | Health management system, activity status measusring device, and data processing device |
US7058453B2 (en) * | 1999-12-14 | 2006-06-06 | Medtronic, Inc. | Apparatus and method for remote therapy and diagnosis in medical devices via interface systems |
US20060122622A1 (en) * | 2004-12-06 | 2006-06-08 | Csaba Truckai | Bone treatment systems and methods |
US20060142815A1 (en) * | 2003-10-15 | 2006-06-29 | Tehrani Amir J | Device and method for treating obstructive sleep apnea |
US7070568B1 (en) * | 2004-03-02 | 2006-07-04 | Pacesetter, Inc. | System and method for diagnosing and tracking congestive heart failure based on the periodicity of Cheyne-Stokes Respiration using an implantable medical device |
US20060149334A1 (en) * | 2003-10-15 | 2006-07-06 | Tehrani Amir J | Device and method for controlling breathing |
US20060155341A1 (en) * | 2003-10-15 | 2006-07-13 | Tehrani Amir J | Device and method for biasing lung volume |
US7082331B1 (en) * | 2004-04-21 | 2006-07-25 | Pacesetter, Inc. | System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device |
US20060167523A1 (en) * | 2003-10-15 | 2006-07-27 | Tehrani Amir J | Device and method for improving upper airway functionality |
Family Cites Families (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US101833A (en) * | 1870-04-12 | Improved coal-box | ||
US61320A (en) * | 1867-01-22 | of lewiston | ||
US61315A (en) * | 1867-01-22 | Improved apparatus for decomposing animal and vegetable substances | ||
US85734A (en) * | 1869-01-12 | Improvement in gr | ||
US61319A (en) * | 1867-01-22 | Improvement in pumps | ||
US99479A (en) * | 1870-02-01 | Edwin r | ||
US21795A (en) * | 1858-10-12 | Improvement in cotton-gins | ||
US540731A (en) * | 1895-06-11 | Wire-reel | ||
US176809A (en) * | 1876-05-02 | Improvement in machinery for cutting waved edges on leather | ||
US39745A (en) * | 1863-09-01 | Improvement in hoisting apparatus | ||
US167523A (en) * | 1875-09-07 | Improvement in sole-channeling machines | ||
US155341A (en) * | 1874-09-22 | Improvement in fertilizers | ||
US240240A (en) * | 1881-04-19 | Beer-faucet | ||
US237963A (en) * | 1881-02-22 | Manufacture of sheet-iron | ||
US127091A (en) * | 1872-05-21 | Improvement in spark-arresters | ||
US142815A (en) * | 1873-09-16 | Improvement in car-couplings | ||
US115561A (en) * | 1871-06-06 | Improvement in electro-sviagnetic separators | ||
US138719A (en) * | 1873-05-06 | Improvement in fly-switches | ||
US149334A (en) * | 1874-04-07 | Improvement in railroad-frogs | ||
US88015A (en) * | 1869-03-23 | Improvement in lifting-jacks | ||
US85866A (en) * | 1869-01-12 | Improved bed-bottom | ||
US85868A (en) * | 1869-01-12 | Improvement in steam water-elevators | ||
US522862A (en) * | 1894-07-10 | Sawhorse | ||
US74741A (en) * | 1868-02-18 | George w | ||
US204213A (en) * | 1878-05-28 | Improvement in loom-pickers | ||
US247729A (en) * | 1881-09-27 | Corset-stay | ||
US111040A (en) * | 1871-01-17 | Improvement in fluid-meters | ||
US85865A (en) * | 1869-01-12 | Improvement in threshing-knives | ||
US193697A (en) * | 1877-07-31 | Improvement in mowers | ||
US174287A (en) * | 1876-02-29 | Improvement in tool-holders | ||
US300094A (en) * | 1884-06-10 | Machine | ||
US345202A (en) * | 1886-07-06 | Treating lac | ||
US85869A (en) * | 1869-01-12 | Improvement in horse-rakes | ||
US146918A (en) * | 1874-01-27 | Improvement in car-couplings | ||
US65563A (en) * | 1867-06-11 | Julius hackert | ||
US85867A (en) * | 1869-01-12 | Improvement in blind-fastener | ||
US119711A (en) * | 1871-10-10 | Improvement in staple-machines | ||
US540733A (en) * | 1895-06-11 | Ernst gerstenberg and herman barghausen | ||
US215082A (en) * | 1879-05-06 | Improvement in type-writing machines | ||
US55060A (en) * | 1866-05-29 | Improvement in harvester-rakes | ||
US59240A (en) * | 1866-10-30 | Maeshall t | ||
US36294A (en) * | 1862-08-26 | Improved portable sugar-evaporatx | ||
US122622A (en) * | 1872-01-09 | Improvement in compartment-cars for railways | ||
US148897A (en) * | 1874-03-24 | Improvement in machines for pressing pantaloons | ||
US225226A (en) * | 1880-03-09 | Rotary engine | ||
US281219A (en) * | 1883-07-10 | Half to alonzo e | ||
US65567A (en) * | 1867-06-11 | Improved soeew machine | ||
US211173A (en) * | 1879-01-07 | Improvement in wagon-tracks for roads | ||
US574507A (en) * | 1897-01-05 | Account-keeping book | ||
US540732A (en) * | 1895-06-11 | Martin freund | ||
US56519A (en) * | 1866-07-24 | Improvement in clamps for holding saws | ||
US77953A (en) * | 1868-05-19 | b i c k e | ||
US681192A (en) * | 1900-11-19 | 1901-08-27 | Natural Food Company | Marking-machine. |
US678535A (en) * | 1901-02-02 | 1901-07-16 | Austen Bigg | Hoe. |
US911218A (en) * | 1908-02-17 | 1909-02-02 | Elias B Wrenn | Trace-holder. |
US1496918A (en) * | 1922-08-23 | 1924-06-10 | Frederick M Baldwin | Signaling device for vehicles |
US3773051A (en) | 1972-03-01 | 1973-11-20 | Research Corp | Method and apparatus for stimulation of body tissue |
US4146918A (en) * | 1978-01-18 | 1979-03-27 | Albert Tureck | Photographic flash reflector and diffuser system |
US5265604A (en) | 1990-05-14 | 1993-11-30 | Vince Dennis J | Demand - diaphragmatic pacing (skeletal muscle pressure modified) |
US5056519A (en) | 1990-05-14 | 1991-10-15 | Vince Dennis J | Unilateral diaphragmatic pacer |
US5190036A (en) * | 1991-02-28 | 1993-03-02 | Linder Steven H | Abdominal binder for effectuating cough stimulation |
US5174287A (en) | 1991-05-28 | 1992-12-29 | Medtronic, Inc. | Airway feedback measurement system responsive to detected inspiration and obstructive apnea event |
US5572543A (en) | 1992-04-09 | 1996-11-05 | Deutsch Aerospace Ag | Laser system with a micro-mechanically moved mirror |
FR2739760B1 (en) * | 1995-10-11 | 1997-12-12 | Salomon Sa | METHOD AND DEVICE FOR HEATING AN INTERIOR SHOE LINING |
SE9603841D0 (en) | 1996-10-18 | 1996-10-18 | Pacesetter Ab | A tissue stimulating apparatus |
US5830008A (en) | 1996-12-17 | 1998-11-03 | The Whitaker Corporation | Panel mountable connector |
WO1999020339A1 (en) | 1997-10-17 | 1999-04-29 | Respironics, Inc. | Muscle stimulating device and method for diagnosing and treating a breathing disorder |
US6021362A (en) * | 1998-02-17 | 2000-02-01 | Maggard; Karl J. | Method and apparatus for dispensing samples and premiums |
CN103641885A (en) | 1998-05-06 | 2014-03-19 | 基因技术股份有限公司 | Protein purification by ion exchange chromatography |
AUPP366398A0 (en) | 1998-05-22 | 1998-06-18 | Resmed Limited | Ventilatory assistance for treatment of cardiac failure and cheyne-stokes breathing |
US6312399B1 (en) | 1998-06-11 | 2001-11-06 | Cprx, Llc | Stimulatory device and methods to enhance venous blood return during cardiopulmonary resuscitation |
US6463327B1 (en) | 1998-06-11 | 2002-10-08 | Cprx Llc | Stimulatory device and methods to electrically stimulate the phrenic nerve |
SE9802335D0 (en) | 1998-06-30 | 1998-06-30 | Siemens Elema Ab | Breathing Help System |
AU5130199A (en) * | 1998-07-27 | 2000-02-21 | Case Western Reserve University | Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea |
US7117032B2 (en) | 1999-03-01 | 2006-10-03 | Quantum Intech, Inc. | Systems and methods for facilitating physiological coherence using respiration training |
US6314324B1 (en) | 1999-05-05 | 2001-11-06 | Respironics, Inc. | Vestibular stimulation system and method |
US6480733B1 (en) | 1999-11-10 | 2002-11-12 | Pacesetter, Inc. | Method for monitoring heart failure |
US6710094B2 (en) * | 1999-12-29 | 2004-03-23 | Styrochem Delaware, Inc. | Processes for preparing patterns for use in metal castings |
US6666830B1 (en) | 2000-08-17 | 2003-12-23 | East River Ventures, Lp | System and method for detecting the onset of an obstructive sleep apnea event |
US6357438B1 (en) * | 2000-10-19 | 2002-03-19 | Mallinckrodt Inc. | Implantable sensor for proportional assist ventilation |
US6633779B1 (en) | 2000-11-27 | 2003-10-14 | Science Medicus, Inc. | Treatment of asthma and respiratory disease by means of electrical neuro-receptive waveforms |
US6572949B1 (en) * | 2001-08-30 | 2003-06-03 | Carlton Paul Lewis | Paint mask and method of using |
FR2829917B1 (en) | 2001-09-24 | 2004-06-11 | Ela Medical Sa | ACTIVE MEDICAL DEVICE INCLUDING MEANS FOR DIAGNOSING THE RESPIRATORY PROFILE |
US20030195571A1 (en) | 2002-04-12 | 2003-10-16 | Burnes John E. | Method and apparatus for the treatment of central sleep apnea using biventricular pacing |
US20030204213A1 (en) | 2002-04-30 | 2003-10-30 | Jensen Donald N. | Method and apparatus to detect and monitor the frequency of obstructive sleep apnea |
US20030225339A1 (en) | 2002-05-06 | 2003-12-04 | Respironics Novametrix | Methods for inducing temporary changes in ventilation for estimation of hemodynamic performance |
SE0202537D0 (en) * | 2002-08-28 | 2002-08-28 | Siemens Elema Ab | Nerve stimulation apparatus |
JP4095391B2 (en) * | 2002-09-24 | 2008-06-04 | キヤノン株式会社 | Position detection method |
US8672852B2 (en) * | 2002-12-13 | 2014-03-18 | Intercure Ltd. | Apparatus and method for beneficial modification of biorhythmic activity |
US20050020240A1 (en) * | 2003-02-07 | 2005-01-27 | Darin Minter | Private wireless network |
US20050261747A1 (en) | 2003-05-16 | 2005-11-24 | Schuler Eleanor L | Method and system to control respiration by means of neuro-electrical coded signals |
US7532934B2 (en) * | 2003-09-18 | 2009-05-12 | Cardiac Pacemakers, Inc. | Snoring detection system and method |
US6905788B2 (en) * | 2003-09-12 | 2005-06-14 | Eastman Kodak Company | Stabilized OLED device |
US8140164B2 (en) * | 2003-10-15 | 2012-03-20 | Rmx, Llc | Therapeutic diaphragm stimulation device and method |
US20120158091A1 (en) * | 2003-10-15 | 2012-06-21 | Rmx, Llc | Therapeutic diaphragm stimulation device and method |
US8265759B2 (en) | 2003-10-15 | 2012-09-11 | Rmx, Llc | Device and method for treating disorders of the cardiovascular system or heart |
US8160711B2 (en) | 2003-10-15 | 2012-04-17 | Rmx, Llc | Multimode device and method for controlling breathing |
US20080161878A1 (en) | 2003-10-15 | 2008-07-03 | Tehrani Amir J | Device and method to for independently stimulating hemidiaphragms |
US9259573B2 (en) * | 2003-10-15 | 2016-02-16 | Rmx, Llc | Device and method for manipulating exhalation |
WO2005074361A2 (en) | 2004-02-05 | 2005-08-18 | Earlysense Ltd. | Techniques for prediction and monitoring of respiration-manifested clinical episodes |
DE102004016985B4 (en) | 2004-04-07 | 2010-07-22 | Pari Pharma Gmbh | Aerosol generating device and inhalation device |
US7245971B2 (en) | 2004-04-21 | 2007-07-17 | Pacesetter, Inc. | System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device |
JP4396380B2 (en) | 2004-04-26 | 2010-01-13 | アイシン・エィ・ダブリュ株式会社 | Traffic information transmission device and transmission method |
US7153271B2 (en) | 2004-05-20 | 2006-12-26 | Airmatrix Technologies, Inc. | Method and system for diagnosing central versus obstructive apnea |
US20060122661A1 (en) * | 2004-12-03 | 2006-06-08 | Mandell Lee J | Diaphragmatic pacing with activity monitor adjustment |
US7680538B2 (en) | 2005-03-31 | 2010-03-16 | Case Western Reserve University | Method of treating obstructive sleep apnea using electrical nerve stimulation |
US8036750B2 (en) | 2005-06-13 | 2011-10-11 | Cardiac Pacemakers, Inc. | System for neural control of respiration |
US20080021506A1 (en) * | 2006-05-09 | 2008-01-24 | Massachusetts General Hospital | Method and device for the electrical treatment of sleep apnea and snoring |
US8280513B2 (en) | 2006-12-22 | 2012-10-02 | Rmx, Llc | Device and method to treat flow limitations |
-
2003
- 2003-10-15 US US10/686,891 patent/US8467876B2/en active Active
-
2004
- 2004-10-15 US US10/966,421 patent/US8255056B2/en active Active
- 2004-10-15 WO PCT/US2004/034103 patent/WO2005037366A1/en active Application Filing
- 2004-10-15 US US10/966,484 patent/US20050085869A1/en not_active Abandoned
- 2004-10-15 US US10/966,474 patent/US8412331B2/en active Active
- 2004-10-15 DE DE112004001953T patent/DE112004001953T5/en not_active Withdrawn
- 2004-10-15 DE DE112004001954.0T patent/DE112004001954B4/en not_active Expired - Fee Related
- 2004-10-15 WO PCT/US2004/034213 patent/WO2005037174A2/en active Application Filing
- 2004-10-15 WO PCT/US2004/034170 patent/WO2005037220A2/en active Application Filing
- 2004-10-15 US US10/966,472 patent/US8200336B2/en active Active
- 2004-10-15 WO PCT/US2004/033850 patent/WO2005037172A2/en active Application Filing
- 2004-10-15 US US10/966,487 patent/US20050085734A1/en not_active Abandoned
- 2004-10-15 WO PCT/US2004/034212 patent/WO2005037173A2/en active Application Filing
- 2004-10-15 DE DE112004001957T patent/DE112004001957T5/en not_active Withdrawn
- 2004-10-15 WO PCT/US2004/034211 patent/WO2005037077A2/en active Application Filing
-
2005
- 2005-10-11 US US11/246,439 patent/US20060030894A1/en not_active Abandoned
- 2005-10-13 US US11/249,718 patent/US8348941B2/en active Active
-
2006
- 2006-09-25 US US11/526,949 patent/US8509901B2/en not_active Expired - Fee Related
-
2007
- 2007-10-31 US US11/981,831 patent/US20080183240A1/en not_active Abandoned
- 2007-10-31 US US11/981,727 patent/US20080183239A1/en not_active Abandoned
- 2007-10-31 US US11/981,800 patent/US8116872B2/en active Active
-
2008
- 2008-04-01 US US12/080,133 patent/US20080188903A1/en not_active Abandoned
-
2013
- 2013-03-26 US US13/851,003 patent/US20130296973A1/en not_active Abandoned
- 2013-06-11 US US13/915,316 patent/US20130296964A1/en not_active Abandoned
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4827935A (en) * | 1986-04-24 | 1989-05-09 | Purdue Research Foundation | Demand electroventilator |
US4830008A (en) * | 1987-04-24 | 1989-05-16 | Meer Jeffrey A | Method and system for treatment of sleep apnea |
US5423327A (en) * | 1989-02-21 | 1995-06-13 | Clauson; William L. | Method for automatic stimulation of mammels in response to blood gas analysis |
US5281219A (en) * | 1990-11-23 | 1994-01-25 | Medtronic, Inc. | Multiple stimulation electrodes |
US5211173A (en) * | 1991-01-09 | 1993-05-18 | Medtronic, Inc. | Servo muscle control |
US5300094A (en) * | 1991-01-09 | 1994-04-05 | Medtronic, Inc. | Servo muscle control |
US5146918A (en) * | 1991-03-19 | 1992-09-15 | Medtronic, Inc. | Demand apnea control of central and obstructive sleep apnea |
US5215082A (en) * | 1991-04-02 | 1993-06-01 | Medtronic, Inc. | Implantable apnea generator with ramp on generator |
US5233983A (en) * | 1991-09-03 | 1993-08-10 | Medtronic, Inc. | Method and apparatus for apnea patient screening |
US5423372A (en) * | 1993-12-27 | 1995-06-13 | Ford Motor Company | Joining sand cores for making castings |
US5524632A (en) * | 1994-01-07 | 1996-06-11 | Medtronic, Inc. | Method for implanting electromyographic sensing electrodes |
US5800470A (en) * | 1994-01-07 | 1998-09-01 | Medtronic, Inc. | Respiratory muscle electromyographic rate responsive pacemaker |
US5483969A (en) * | 1994-09-21 | 1996-01-16 | Medtronic, Inc. | Method and apparatus for providing a respiratory effort waveform for the treatment of obstructive sleep apnea |
US5522862A (en) * | 1994-09-21 | 1996-06-04 | Medtronic, Inc. | Method and apparatus for treating obstructive sleep apnea |
US5540732A (en) * | 1994-09-21 | 1996-07-30 | Medtronic, Inc. | Method and apparatus for impedance detecting and treating obstructive airway disorders |
US5540731A (en) * | 1994-09-21 | 1996-07-30 | Medtronic, Inc. | Method and apparatus for pressure detecting and treating obstructive airway disorders |
US5540733A (en) * | 1994-09-21 | 1996-07-30 | Medtronic, Inc. | Method and apparatus for detecting and treating obstructive sleep apnea |
US5546952A (en) * | 1994-09-21 | 1996-08-20 | Medtronic, Inc. | Method and apparatus for detection of a respiratory waveform |
US5549655A (en) * | 1994-09-21 | 1996-08-27 | Medtronic, Inc. | Method and apparatus for synchronized treatment of obstructive sleep apnea |
US5485851A (en) * | 1994-09-21 | 1996-01-23 | Medtronic, Inc. | Method and apparatus for arousal detection |
US5911218A (en) * | 1995-04-21 | 1999-06-15 | Dimarco; Anthony Fortunato | Method and apparatus for electrical stimulation of the respiratory muscles to achieve artificial ventilation in a patient |
US5766228A (en) * | 1995-10-13 | 1998-06-16 | Ela Medical S.A. | Enslaved active implantable medical device with reduced power consumption |
US6542774B2 (en) * | 1996-04-30 | 2003-04-01 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart |
US6572543B1 (en) * | 1996-06-26 | 2003-06-03 | Medtronic, Inc | Sensor, method of sensor implant and system for treatment of respiratory disorders |
US5895360A (en) * | 1996-06-26 | 1999-04-20 | Medtronic, Inc. | Gain control for a periodic signal and method regarding same |
US5944680A (en) * | 1996-06-26 | 1999-08-31 | Medtronic, Inc. | Respiratory effort detection method and apparatus |
US6021352A (en) * | 1996-06-26 | 2000-02-01 | Medtronic, Inc, | Diagnostic testing methods and apparatus for implantable therapy devices |
US6099479A (en) * | 1996-06-26 | 2000-08-08 | Medtronic, Inc. | Method and apparatus for operating therapy system |
US5876353A (en) * | 1997-01-31 | 1999-03-02 | Medtronic, Inc. | Impedance monitor for discerning edema through evaluation of respiratory rate |
US5797923A (en) * | 1997-05-12 | 1998-08-25 | Aiyar; Harish | Electrode delivery instrument |
US6251126B1 (en) * | 1998-04-23 | 2001-06-26 | Medtronic Inc | Method and apparatus for synchronized treatment of obstructive sleep apnea |
US6269269B1 (en) * | 1998-04-23 | 2001-07-31 | Medtronic Inc. | Method and apparatus for synchronized treatment of obstructive sleep apnea |
US6224562B1 (en) * | 1998-06-11 | 2001-05-01 | Cprx Llc | Methods and devices for performing cardiopulmonary resuscitation |
US6574507B1 (en) * | 1998-07-06 | 2003-06-03 | Ela Medical S.A. | Active implantable medical device for treating sleep apnea syndrome by electrostimulation |
US6345202B2 (en) * | 1998-08-14 | 2002-02-05 | Advanced Bionics Corporation | Method of treating obstructive sleep apnea using implantable electrodes |
US6212435B1 (en) * | 1998-11-13 | 2001-04-03 | Respironics, Inc. | Intraoral electromuscular stimulation device and method |
US20060064030A1 (en) * | 1999-04-16 | 2006-03-23 | Cosentino Daniel L | System, method, and apparatus for combining information from an implanted device with information from a patient monitoring apparatus |
US6512949B1 (en) * | 1999-07-12 | 2003-01-28 | Medtronic, Inc. | Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto |
US6527729B1 (en) * | 1999-11-10 | 2003-03-04 | Pacesetter, Inc. | Method for monitoring patient using acoustic sensor |
US6600949B1 (en) * | 1999-11-10 | 2003-07-29 | Pacesetter, Inc. | Method for monitoring heart failure via respiratory patterns |
US6908437B2 (en) * | 1999-11-16 | 2005-06-21 | Cardiac Intelligence Corporation | System and method for diagnosing and monitoring congestive heart failure for automated remote patient care |
US6752765B1 (en) * | 1999-12-01 | 2004-06-22 | Medtronic, Inc. | Method and apparatus for monitoring heart rate and abnormal respiration |
US6415183B1 (en) * | 1999-12-09 | 2002-07-02 | Cardiac Pacemakers, Inc. | Method and apparatus for diaphragmatic pacing |
US7058453B2 (en) * | 1999-12-14 | 2006-06-06 | Medtronic, Inc. | Apparatus and method for remote therapy and diagnosis in medical devices via interface systems |
US20030127091A1 (en) * | 1999-12-15 | 2003-07-10 | Chang Yung Chi | Scientific respiration for self-health-care |
US6589188B1 (en) * | 2000-05-05 | 2003-07-08 | Pacesetter, Inc. | Method for monitoring heart failure via respiratory patterns |
US20020049482A1 (en) * | 2000-06-14 | 2002-04-25 | Willa Fabian | Lifestyle management system |
US6735479B2 (en) * | 2000-06-14 | 2004-05-11 | Medtronic, Inc. | Lifestyle management system |
US20040059240A1 (en) * | 2001-04-30 | 2004-03-25 | Medtronic, Inc. | Method and apparatus to detect and treat sleep respiratory events |
US6731984B2 (en) * | 2001-06-07 | 2004-05-04 | Medtronic, Inc. | Method for providing a therapy to a patient involving modifying the therapy after detecting an onset of sleep in the patient, and implantable medical device embodying same |
US20040176809A1 (en) * | 2001-06-07 | 2004-09-09 | Medtronic, Inc. | Method and apparatus for modifying delivery of a therapy in response to onset of sleep |
US20030153954A1 (en) * | 2002-02-14 | 2003-08-14 | Euljoon Park | Sleep apnea therapy device using dynamic overdrive pacing |
US20030153956A1 (en) * | 2002-02-14 | 2003-08-14 | Euljoon Park | Cardiac stimulation device including sleep apnea prevention and treatment |
US20030153953A1 (en) * | 2002-02-14 | 2003-08-14 | Euljoon Park | Stimulation device for sleep apnea prevention, detection and treatment |
US20030153955A1 (en) * | 2002-02-14 | 2003-08-14 | Euljoon Park | Cardiac stimulation device including sleep apnea prevention and treatment |
US6881192B1 (en) * | 2002-06-12 | 2005-04-19 | Pacesetter, Inc. | Measurement of sleep apnea duration and evaluation of response therapies using duration metrics |
US20060064325A1 (en) * | 2002-10-02 | 2006-03-23 | Suzuken Co., Ltd | Health management system, activity status measusring device, and data processing device |
US20040077953A1 (en) * | 2002-10-18 | 2004-04-22 | Turcott Robert G. | Hemodynamic analysis |
US20040088015A1 (en) * | 2002-10-31 | 2004-05-06 | Casavant David A. | Respiratory nerve stimulation |
US20040111040A1 (en) * | 2002-12-04 | 2004-06-10 | Quan Ni | Detection of disordered breathing |
US20040122484A1 (en) * | 2002-12-18 | 2004-06-24 | John Hatlestad | Advanced patient management for defining, identifying and using predetermined health-related events |
US20040134496A1 (en) * | 2003-01-10 | 2004-07-15 | Cho Yong K. | Method and apparatus for detecting respiratory disturbances |
US20040138719A1 (en) * | 2003-01-10 | 2004-07-15 | Cho Yong K. | System and method for automatically monitoring and delivering therapy for sleep-related disordered breathing |
US20050119711A1 (en) * | 2003-01-10 | 2005-06-02 | Cho Yong K. | Apparatus and method for monitoring for disordered breathing |
US20050107860A1 (en) * | 2003-07-23 | 2005-05-19 | Ignagni Anthony R. | Mapping probe system for neuromuscular electrical stimulation apparatus |
US20050021102A1 (en) * | 2003-07-23 | 2005-01-27 | Ignagni Anthony R. | System and method for conditioning a diaphragm of a patient |
US20050115561A1 (en) * | 2003-08-18 | 2005-06-02 | Stahmann Jeffrey E. | Patient monitoring, diagnosis, and/or therapy systems and methods |
US20050043644A1 (en) * | 2003-08-18 | 2005-02-24 | Stahmann Jeffrey E. | Prediction of disordered breathing |
US20050043772A1 (en) * | 2003-08-18 | 2005-02-24 | Stahmann Jeffrey E. | Therapy triggered by prediction of disordered breathing |
US20050039745A1 (en) * | 2003-08-18 | 2005-02-24 | Stahmann Jeffrey E. | Adaptive therapy for disordered breathing |
US20050101833A1 (en) * | 2003-09-02 | 2005-05-12 | Biotronik Gmbh & Co. Kg | Apparatus for the treatment of sleep apnea |
US20050055060A1 (en) * | 2003-09-05 | 2005-03-10 | Steve Koh | Determination of respiratory characteristics from AV conduction intervals |
US20050076909A1 (en) * | 2003-09-18 | 2005-04-14 | Stahmann Jeffrey E. | Synergistic use of medical devices for detecting medical disorders |
US20050080461A1 (en) * | 2003-09-18 | 2005-04-14 | Stahmann Jeffrey E. | System and method for moderating a therapy delivered during sleep using physiologic data acquired during non-sleep |
US20050074741A1 (en) * | 2003-09-18 | 2005-04-07 | Kent Lee | System and method for discrimination of central and obstructive disordered breathing events |
US20050065567A1 (en) * | 2003-09-18 | 2005-03-24 | Cardiac Pacemakers, Inc. | Therapy control based on cardiopulmonary status |
US20050145246A1 (en) * | 2003-09-18 | 2005-07-07 | Hartley Jesse W. | Posture detection system and method |
US20050061320A1 (en) * | 2003-09-18 | 2005-03-24 | Cardiac Pacemakers, Inc. | Coordinated use of respiratory and cardiac therapies for sleep disordered breathing |
US20050061315A1 (en) * | 2003-09-18 | 2005-03-24 | Kent Lee | Feedback system and method for sleep disordered breathing therapy |
US20050061319A1 (en) * | 2003-09-18 | 2005-03-24 | Cardiac Pacemakers, Inc. | Methods and systems for implantably monitoring external breathing therapy |
US20050065563A1 (en) * | 2003-09-23 | 2005-03-24 | Avram Scheiner | Paced ventilation therapy by an implantable cardiac device |
US20050085867A1 (en) * | 2003-10-15 | 2005-04-21 | Tehrani Amir J. | System and method for diaphragm stimulation |
US20050085869A1 (en) * | 2003-10-15 | 2005-04-21 | Tehrani Amir J. | System and method for mapping diaphragm electrode sites |
US20070021795A1 (en) * | 2003-10-15 | 2007-01-25 | Inspiration Medical, Inc. | Device and method for adding to breathing |
US20060167523A1 (en) * | 2003-10-15 | 2006-07-27 | Tehrani Amir J | Device and method for improving upper airway functionality |
US20060030894A1 (en) * | 2003-10-15 | 2006-02-09 | Tehrani Amir J | Breathing disorder detection and therapy device for providing intrinsic breathing |
US20060036294A1 (en) * | 2003-10-15 | 2006-02-16 | Tehrani Amir J | Patient compliance management device and method |
US20060155341A1 (en) * | 2003-10-15 | 2006-07-13 | Tehrani Amir J | Device and method for biasing lung volume |
US20050085868A1 (en) * | 2003-10-15 | 2005-04-21 | Tehrani Amir J. | Breathing therapy device and method |
US20050085866A1 (en) * | 2003-10-15 | 2005-04-21 | Tehrani Amir J. | Breathing disorder and precursor predictor and therapy delivery device and method |
US20050085865A1 (en) * | 2003-10-15 | 2005-04-21 | Tehrani Amir J. | Breathing disorder detection and therapy delivery device and method |
US20060149334A1 (en) * | 2003-10-15 | 2006-07-06 | Tehrani Amir J | Device and method for controlling breathing |
US20060142815A1 (en) * | 2003-10-15 | 2006-06-29 | Tehrani Amir J | Device and method for treating obstructive sleep apnea |
US20050148897A1 (en) * | 2003-12-24 | 2005-07-07 | Cho Yong K. | Implantable medical device with sleep disordered breathing monitoring |
US20050165457A1 (en) * | 2004-01-26 | 2005-07-28 | Michael Benser | Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration |
US7070568B1 (en) * | 2004-03-02 | 2006-07-04 | Pacesetter, Inc. | System and method for diagnosing and tracking congestive heart failure based on the periodicity of Cheyne-Stokes Respiration using an implantable medical device |
US7082331B1 (en) * | 2004-04-21 | 2006-07-25 | Pacesetter, Inc. | System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device |
US20060058852A1 (en) * | 2004-09-10 | 2006-03-16 | Steve Koh | Multi-variable feedback control of stimulation for inspiratory facilitation |
US20060122622A1 (en) * | 2004-12-06 | 2006-06-08 | Csaba Truckai | Bone treatment systems and methods |
Cited By (205)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7206635B2 (en) * | 2001-06-07 | 2007-04-17 | Medtronic, Inc. | Method and apparatus for modifying delivery of a therapy in response to onset of sleep |
US8406885B2 (en) | 2003-07-23 | 2013-03-26 | Synapse Biomedical, Inc. | System and method for conditioning a diaphragm of a patient |
US20110060381A1 (en) * | 2003-07-23 | 2011-03-10 | Ignagni Anthony R | System and Method for Conditioning a Diaphragm of a Patient |
US8706236B2 (en) | 2003-07-23 | 2014-04-22 | Synapse Biomedical, Inc. | System and method for conditioning a diaphragm of a patient |
US8509901B2 (en) | 2003-10-15 | 2013-08-13 | Rmx, Llc | Device and method for adding to breathing |
US20060155341A1 (en) * | 2003-10-15 | 2006-07-13 | Tehrani Amir J | Device and method for biasing lung volume |
US20060149334A1 (en) * | 2003-10-15 | 2006-07-06 | Tehrani Amir J | Device and method for controlling breathing |
US8160711B2 (en) | 2003-10-15 | 2012-04-17 | Rmx, Llc | Multimode device and method for controlling breathing |
US8348941B2 (en) | 2003-10-15 | 2013-01-08 | Rmx, Llc | Demand-based system for treating breathing disorders |
US20060247729A1 (en) * | 2003-10-15 | 2006-11-02 | Tehrani Amir J | Multimode device and method for controlling breathing |
US20050085867A1 (en) * | 2003-10-15 | 2005-04-21 | Tehrani Amir J. | System and method for diaphragm stimulation |
US20070021795A1 (en) * | 2003-10-15 | 2007-01-25 | Inspiration Medical, Inc. | Device and method for adding to breathing |
US8412331B2 (en) | 2003-10-15 | 2013-04-02 | Rmx, Llc | Breathing therapy device and method |
US8335567B2 (en) | 2003-10-15 | 2012-12-18 | Rmx, Llc | Multimode device and method for controlling breathing |
US8467876B2 (en) * | 2003-10-15 | 2013-06-18 | Rmx, Llc | Breathing disorder detection and therapy delivery device and method |
US8265759B2 (en) | 2003-10-15 | 2012-09-11 | Rmx, Llc | Device and method for treating disorders of the cardiovascular system or heart |
US20060036294A1 (en) * | 2003-10-15 | 2006-02-16 | Tehrani Amir J | Patient compliance management device and method |
US8255056B2 (en) | 2003-10-15 | 2012-08-28 | Rmx, Llc | Breathing disorder and precursor predictor and therapy delivery device and method |
US8244358B2 (en) | 2003-10-15 | 2012-08-14 | Rmx, Llc | Device and method for treating obstructive sleep apnea |
US20080167695A1 (en) * | 2003-10-15 | 2008-07-10 | Tehrani Amir J | Therapeutic diaphragm stimulation device and method |
US8200336B2 (en) | 2003-10-15 | 2012-06-12 | Rmx, Llc | System and method for diaphragm stimulation |
US20060030894A1 (en) * | 2003-10-15 | 2006-02-09 | Tehrani Amir J | Breathing disorder detection and therapy device for providing intrinsic breathing |
US7970475B2 (en) | 2003-10-15 | 2011-06-28 | Rmx, Llc | Device and method for biasing lung volume |
US7979128B2 (en) | 2003-10-15 | 2011-07-12 | Rmx, Llc | Device and method for gradually controlling breathing |
US20050085869A1 (en) * | 2003-10-15 | 2005-04-21 | Tehrani Amir J. | System and method for mapping diaphragm electrode sites |
US20060122662A1 (en) * | 2003-10-15 | 2006-06-08 | Tehrani Amir J | Device and method for increasing functional residual capacity |
US20110230932A1 (en) * | 2003-10-15 | 2011-09-22 | Rmx, Llc | Device and method for independently stimulating hemidiaphragms |
US8140164B2 (en) | 2003-10-15 | 2012-03-20 | Rmx, Llc | Therapeutic diaphragm stimulation device and method |
US20080188904A1 (en) * | 2003-10-15 | 2008-08-07 | Tehrani Amir J | Device and method for treating disorders of the cardiovascular system or heart |
US9259573B2 (en) | 2003-10-15 | 2016-02-16 | Rmx, Llc | Device and method for manipulating exhalation |
US20080208281A1 (en) * | 2003-10-15 | 2008-08-28 | Tehrani Amir J | Device and method for biasing and stimulating respiration |
US8116872B2 (en) | 2003-10-15 | 2012-02-14 | Rmx, Llc | Device and method for biasing and stimulating respiration |
US9370657B2 (en) | 2003-10-15 | 2016-06-21 | Rmx, Llc | Device for manipulating tidal volume and breathing entrainment |
US8942779B2 (en) | 2004-02-05 | 2015-01-27 | Early Sense Ltd. | Monitoring a condition of a subject |
US8517953B2 (en) | 2004-02-05 | 2013-08-27 | Earlysense Ltd. | Techniques for prediction and monitoring of coughing-manifested clinical episodes |
US9131902B2 (en) | 2004-02-05 | 2015-09-15 | Earlysense Ltd. | Prediction and monitoring of clinical episodes |
US8679030B2 (en) | 2004-02-05 | 2014-03-25 | Earlysense Ltd. | Monitoring a condition of a subject |
US8491492B2 (en) | 2004-02-05 | 2013-07-23 | Earlysense Ltd. | Monitoring a condition of a subject |
US20080269625A1 (en) * | 2004-02-05 | 2008-10-30 | Earlysense Ltd. | Prediction and monitoring of clinical episodes |
US8603010B2 (en) | 2004-02-05 | 2013-12-10 | Earlysense Ltd. | Techniques for prediction and monitoring of clinical episodes |
US8992434B2 (en) | 2004-02-05 | 2015-03-31 | Earlysense Ltd. | Prediction and monitoring of clinical episodes |
US8840564B2 (en) | 2004-02-05 | 2014-09-23 | Early Sense Ltd. | Monitoring a condition of a subject |
US8403865B2 (en) | 2004-02-05 | 2013-03-26 | Earlysense Ltd. | Prediction and monitoring of clinical episodes |
US8731646B2 (en) | 2004-02-05 | 2014-05-20 | Earlysense Ltd. | Prediction and monitoring of clinical episodes |
US8376954B2 (en) | 2004-02-05 | 2013-02-19 | Earlysense Ltd. | Techniques for prediction and monitoring of respiration-manifested clinical episodes |
US20070265611A1 (en) * | 2004-07-23 | 2007-11-15 | Ignagni Anthony R | Ventilatory assist system and methods to improve respiratory function |
US7962215B2 (en) | 2004-07-23 | 2011-06-14 | Synapse Biomedical, Inc. | Ventilatory assist system and methods to improve respiratory function |
US20080004668A1 (en) * | 2004-08-09 | 2008-01-03 | Cardiac Pacemakers, Inc. | Cardiopulmonary functional status assessment via heart rate response dectection by implantable cardiac device |
US7869877B2 (en) | 2004-08-09 | 2011-01-11 | Cardiac Pacemakers, Inc. | Cardiopulmonary functional status assessment via heart rate response detection by implantable cardiac device |
US8538525B2 (en) | 2004-08-12 | 2013-09-17 | Cardiac Pacemakers, Inc. | Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device |
US8903491B2 (en) | 2004-08-12 | 2014-12-02 | Cardiac Pacemakers, Inc. | Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device |
US20060101871A1 (en) * | 2004-11-12 | 2006-05-18 | Matsushita Electric Industrial Co., Ltd. | Drum type washing and drying machine |
US7704211B1 (en) * | 2005-03-21 | 2010-04-27 | Pacesetter, Inc. | Method and apparatus for assessing fluid level in lungs |
US8761876B2 (en) | 2005-04-20 | 2014-06-24 | Cardiac Pacemakers, Inc. | Thoracic or intracardiac impedance detection with automatic vector selection |
US20100056884A1 (en) * | 2005-04-20 | 2010-03-04 | Jonathan Kwok | Thoracic or intracardiac impedance detection with automatic vector selection |
US8473050B2 (en) | 2005-04-20 | 2013-06-25 | Cardiac Pacemakers, Inc. | Thoracic or intracardiac impedance detection with automatic vector selection |
US7630763B2 (en) | 2005-04-20 | 2009-12-08 | Cardiac Pacemakers, Inc. | Thoracic or intracardiac impedance detection with automatic vector selection |
US8014860B2 (en) | 2005-04-20 | 2011-09-06 | Cardiac Pacemakers, Inc. | Thoracic or intracardiac impedance detection with automatic vector selection |
US20060241512A1 (en) * | 2005-04-20 | 2006-10-26 | Cardiac Pacemakers, Inc. | Thoracic or intracardiac impedance detection with automatic vector selection |
US8295927B2 (en) | 2005-05-25 | 2012-10-23 | Cardiac Pacemakers, Inc. | Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods |
US8126548B2 (en) | 2005-05-25 | 2012-02-28 | Cardiac Pacemakers, Inc. | Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods |
US20080114410A1 (en) * | 2005-05-25 | 2008-05-15 | Cardiac Pacemakers, Inc. | Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods |
US20070021678A1 (en) * | 2005-07-19 | 2007-01-25 | Cardiac Pacemakers, Inc. | Methods and apparatus for monitoring physiological responses to steady state activity |
US9839781B2 (en) | 2005-08-22 | 2017-12-12 | Cardiac Pacemakers, Inc. | Intracardiac impedance and its applications |
US20070043394A1 (en) * | 2005-08-22 | 2007-02-22 | Cardiac Pacemakers, Inc | Intracardiac impedance and its applications |
US8494618B2 (en) * | 2005-08-22 | 2013-07-23 | Cardiac Pacemakers, Inc. | Intracardiac impedance and its applications |
US20070044669A1 (en) * | 2005-08-24 | 2007-03-01 | Geise Gregory D | Aluminum can compacting mechanism with improved actuation handle assembly |
US20070049793A1 (en) * | 2005-08-25 | 2007-03-01 | Ignagni Anthony R | Method And Apparatus For Transgastric Neurostimulation |
US9050005B2 (en) | 2005-08-25 | 2015-06-09 | Synapse Biomedical, Inc. | Method and apparatus for transgastric neurostimulation |
US11350848B2 (en) | 2005-09-16 | 2022-06-07 | Cardiac Pacemakers, Inc. | System and method for generating a trend parameter based on respiration rate distribution |
US8372012B2 (en) | 2005-09-16 | 2013-02-12 | Cardiac Pacemakers, Inc. | System and method for generating a trend parameter based on respiration rate distribution |
US20100228133A1 (en) * | 2005-09-16 | 2010-09-09 | Averina Viktoria A | System and Method for Generating a Trend Parameter Based on Respiration Rate Distribution |
US20070066905A1 (en) * | 2005-09-21 | 2007-03-22 | Cardiac Pacemakers, Inc. | Method and apparatus for controlling cardiac resynchronization therapy using cardiac impedance |
US7974691B2 (en) | 2005-09-21 | 2011-07-05 | Cardiac Pacemakers, Inc. | Method and apparatus for controlling cardiac resynchronization therapy using cardiac impedance |
US8712521B2 (en) | 2005-09-21 | 2014-04-29 | Cardiac Pacemakers, Inc. | Method and apparatus for controlling cardiac resynchronization therapy using cardiac impedance |
US20070118054A1 (en) * | 2005-11-01 | 2007-05-24 | Earlysense Ltd. | Methods and systems for monitoring patients for clinical episodes |
US9026199B2 (en) | 2005-11-01 | 2015-05-05 | Earlysense Ltd. | Monitoring a condition of a subject |
US8244359B2 (en) | 2005-11-18 | 2012-08-14 | Respicardia, Inc. | System and method to modulate phrenic nerve to prevent sleep apnea |
US20070118183A1 (en) * | 2005-11-18 | 2007-05-24 | Mark Gelfand | System and method to modulate phrenic nerve to prevent sleep apnea |
US11305119B2 (en) | 2005-11-18 | 2022-04-19 | Zoll Respicardia, Inc. | System and method to modulate phrenic nerve to prevent sleep apnea |
US10518090B2 (en) | 2005-11-18 | 2019-12-31 | Respicardia, Inc. | System and method to modulate phrenic nerve to prevent sleep apnea |
US20070150023A1 (en) * | 2005-12-02 | 2007-06-28 | Ignagni Anthony R | Transvisceral neurostimulation mapping device and method |
US20080125828A1 (en) * | 2006-03-09 | 2008-05-29 | Ignagni Anthony R | Ventilatory assist system and methods to improve respiratory function |
US8676323B2 (en) | 2006-03-09 | 2014-03-18 | Synapse Biomedical, Inc. | Ventilatory assist system and methods to improve respiratory function |
US20080109047A1 (en) * | 2006-10-26 | 2008-05-08 | Pless Benjamin D | Apnea treatment device |
US7917194B1 (en) * | 2006-11-15 | 2011-03-29 | Pacesetter, Inc. | Method and apparatus for detecting pulmonary edema |
US10406366B2 (en) | 2006-11-17 | 2019-09-10 | Respicardia, Inc. | Transvenous phrenic nerve stimulation system |
US20080154330A1 (en) * | 2006-12-22 | 2008-06-26 | Tehrani Amir J | Device and method to treat flow limitations |
US8280513B2 (en) | 2006-12-22 | 2012-10-02 | Rmx, Llc | Device and method to treat flow limitations |
US9968266B2 (en) | 2006-12-27 | 2018-05-15 | Cardiac Pacemakers, Inc. | Risk stratification based heart failure detection algorithm |
US9744351B1 (en) | 2007-01-22 | 2017-08-29 | Respicardia, Inc. | Device and method for the treatment of breathing disorders and cardiac disorders |
US10300270B2 (en) | 2007-01-22 | 2019-05-28 | Respicardia, Inc. | Device and method for the treatment of breathing disorders and cardiac disorders |
US8909341B2 (en) | 2007-01-22 | 2014-12-09 | Respicardia, Inc. | Device and method for the treatment of breathing disorders and cardiac disorders |
US20080208282A1 (en) * | 2007-01-22 | 2008-08-28 | Mark Gelfand | Device and method for the treatment of breathing disorders and cardiac disorders |
US20080188867A1 (en) * | 2007-02-05 | 2008-08-07 | Ignagni Anthony R | Removable intramuscular electrode |
US9079016B2 (en) | 2007-02-05 | 2015-07-14 | Synapse Biomedical, Inc. | Removable intramuscular electrode |
US20080234556A1 (en) * | 2007-03-20 | 2008-09-25 | Cardiac Pacemakers, Inc. | Method and apparatus for sensing respiratory activities using sensor in lymphatic system |
US8821418B2 (en) | 2007-05-02 | 2014-09-02 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US8734360B2 (en) | 2007-05-02 | 2014-05-27 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US8585607B2 (en) | 2007-05-02 | 2013-11-19 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US20080287820A1 (en) * | 2007-05-17 | 2008-11-20 | Synapse Biomedical, Inc. | Devices and methods for assessing motor point electromyogram as a biomarker |
US9820671B2 (en) | 2007-05-17 | 2017-11-21 | Synapse Biomedical, Inc. | Devices and methods for assessing motor point electromyogram as a biomarker |
US20100160992A1 (en) * | 2007-05-28 | 2010-06-24 | St. Jude Medical Ab | Implantable medical device, system and method |
US9987488B1 (en) | 2007-06-27 | 2018-06-05 | Respicardia, Inc. | Detecting and treating disordered breathing |
US11305114B2 (en) | 2007-06-27 | 2022-04-19 | Zoll Respicardia, Inc. | Detecting and treating disordered breathing |
US8914113B2 (en) | 2007-08-28 | 2014-12-16 | Cardiac Pacemakers, Inc. | Method and apparatus for inspiratory muscle stimulation using implantable device |
US8135471B2 (en) | 2007-08-28 | 2012-03-13 | Cardiac Pacemakers, Inc. | Method and apparatus for inspiratory muscle stimulation using implantable device |
US20090062882A1 (en) * | 2007-08-28 | 2009-03-05 | Cardiac Pacemakers, Inc. | Method and apparatus for inspiratory muscle stimulation using implantable device |
US9320443B2 (en) * | 2007-09-14 | 2016-04-26 | Medtronic Monitoring, Inc. | Multi-sensor patient monitor to detect impending cardiac decompensation |
US10405809B2 (en) | 2007-09-14 | 2019-09-10 | Medtronic Monitoring, Inc | Injectable device for physiological monitoring |
US8116841B2 (en) | 2007-09-14 | 2012-02-14 | Corventis, Inc. | Adherent device with multiple physiological sensors |
US10599814B2 (en) | 2007-09-14 | 2020-03-24 | Medtronic Monitoring, Inc. | Dynamic pairing of patients to data collection gateways |
US8684925B2 (en) | 2007-09-14 | 2014-04-01 | Corventis, Inc. | Injectable device for physiological monitoring |
US8591430B2 (en) | 2007-09-14 | 2013-11-26 | Corventis, Inc. | Adherent device for respiratory monitoring |
US8249686B2 (en) | 2007-09-14 | 2012-08-21 | Corventis, Inc. | Adherent device for sleep disordered breathing |
US9125566B2 (en) * | 2007-09-14 | 2015-09-08 | Medtronic Monitoring, Inc. | Multi-sensor patient monitor to detect impending cardiac decompensation |
US10028699B2 (en) | 2007-09-14 | 2018-07-24 | Medtronic Monitoring, Inc. | Adherent device for sleep disordered breathing |
US9411936B2 (en) | 2007-09-14 | 2016-08-09 | Medtronic Monitoring, Inc. | Dynamic pairing of patients to data collection gateways |
US8285356B2 (en) | 2007-09-14 | 2012-10-09 | Corventis, Inc. | Adherent device with multiple physiological sensors |
US8460189B2 (en) | 2007-09-14 | 2013-06-11 | Corventis, Inc. | Adherent cardiac monitor with advanced sensing capabilities |
US8790257B2 (en) | 2007-09-14 | 2014-07-29 | Corventis, Inc. | Multi-sensor patient monitor to detect impending cardiac decompensation |
US9579020B2 (en) | 2007-09-14 | 2017-02-28 | Medtronic Monitoring, Inc. | Adherent cardiac monitor with advanced sensing capabilities |
US9186089B2 (en) | 2007-09-14 | 2015-11-17 | Medtronic Monitoring, Inc. | Injectable physiological monitoring system |
US9770182B2 (en) | 2007-09-14 | 2017-09-26 | Medtronic Monitoring, Inc. | Adherent device with multiple physiological sensors |
US9538960B2 (en) | 2007-09-14 | 2017-01-10 | Medtronic Monitoring, Inc. | Injectable physiological monitoring system |
US8897868B2 (en) | 2007-09-14 | 2014-11-25 | Medtronic, Inc. | Medical device automatic start-up upon contact to patient tissue |
US8374688B2 (en) | 2007-09-14 | 2013-02-12 | Corventis, Inc. | System and methods for wireless body fluid monitoring |
US20150005590A1 (en) * | 2007-09-14 | 2015-01-01 | Corventis, Inc. | Multi-sensor patient monitor to detect impending cardiac decompensation |
US8428711B2 (en) | 2007-10-10 | 2013-04-23 | Cardiac Pacemakers, Inc. | Respiratory stimulation for treating periodic breathing |
US20090099621A1 (en) * | 2007-10-10 | 2009-04-16 | Zheng Lin | Respiratory stimulation for treating periodic breathing |
US8838245B2 (en) | 2007-10-10 | 2014-09-16 | Cardiac Pacemakers, Inc. | Respiratory stimulation for treating periodic breathing |
US20090118785A1 (en) * | 2007-10-30 | 2009-05-07 | Ignagni Anthony R | Method of improving sleep disordered breathing |
US8478412B2 (en) | 2007-10-30 | 2013-07-02 | Synapse Biomedical, Inc. | Method of improving sleep disordered breathing |
US8428726B2 (en) | 2007-10-30 | 2013-04-23 | Synapse Biomedical, Inc. | Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system |
US9138580B2 (en) | 2007-10-30 | 2015-09-22 | Synapse Biomedical, Inc. | Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system |
US20090192394A1 (en) * | 2008-01-16 | 2009-07-30 | Guttag John V | Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal |
US8868163B2 (en) | 2008-01-16 | 2014-10-21 | Massachusetts Institute Of Technology | Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal |
US8346349B2 (en) * | 2008-01-16 | 2013-01-01 | Massachusetts Institute Of Technology | Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal |
US11865333B2 (en) | 2008-02-07 | 2024-01-09 | Zoll Respicardia, Inc. | Transvascular medical lead |
US9295846B2 (en) | 2008-02-07 | 2016-03-29 | Respicardia, Inc. | Muscle and nerve stimulation |
US11389648B2 (en) | 2008-02-07 | 2022-07-19 | Zoll Respicardia, Inc. | Transvascular medical lead |
US8433412B1 (en) | 2008-02-07 | 2013-04-30 | Respicardia, Inc. | Muscle and nerve stimulation |
WO2009114548A1 (en) * | 2008-03-12 | 2009-09-17 | Corventis, Inc. | Heart failure decompensation prediction based on cardiac rhythm |
JP2011514831A (en) * | 2008-03-12 | 2011-05-12 | コーヴェンティス,インク. | Predicting cardiac decompensation based on cardiac rhythm |
US8718752B2 (en) | 2008-03-12 | 2014-05-06 | Corventis, Inc. | Heart failure decompensation prediction based on cardiac rhythm |
US20140330091A1 (en) * | 2008-03-12 | 2014-11-06 | Corventis, Inc. | Heart failure decompensation prediction based on cardiac rhythm |
US20110054279A1 (en) * | 2008-03-27 | 2011-03-03 | Widemed Ltd. | Diagnosis of periodic breathing |
US8412317B2 (en) | 2008-04-18 | 2013-04-02 | Corventis, Inc. | Method and apparatus to measure bioelectric impedance of patient tissue |
US9883809B2 (en) | 2008-05-01 | 2018-02-06 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US8998830B2 (en) | 2008-05-12 | 2015-04-07 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US8882684B2 (en) | 2008-05-12 | 2014-11-11 | Earlysense Ltd. | Monitoring, predicting and treating clinical episodes |
US20100016748A1 (en) * | 2008-07-17 | 2010-01-21 | Syed Zeeshan H | Motif Discovery in Physiological Datasets: A Methodology for Inferring Predictive Elements |
US8340746B2 (en) | 2008-07-17 | 2012-12-25 | Massachusetts Institute Of Technology | Motif discovery in physiological datasets: a methodology for inferring predictive elements |
US8202223B2 (en) | 2008-09-19 | 2012-06-19 | Medtronic, Inc. | Method and apparatus for determining respiratory effort in a medical device |
US8372013B2 (en) | 2008-09-19 | 2013-02-12 | Medtronic, Inc. | Method and apparatus for determining a respiration parameter in a medical device |
US8047999B2 (en) | 2008-09-19 | 2011-11-01 | Medtronic, Inc. | Filtering of a physiologic signal in a medical device |
US8231536B2 (en) | 2008-09-19 | 2012-07-31 | Medtronic, Inc. | Method and apparatus for detecting respiratory effort in a medical device |
US20100076324A1 (en) * | 2008-09-19 | 2010-03-25 | Cho Yong K | Method and apparatus for detecting respiratory effort in a medical device |
US20100076325A1 (en) * | 2008-09-19 | 2010-03-25 | Cho Yong K | Method and apparatus for determining respiratory effort in a medical device |
US8823490B2 (en) | 2008-12-15 | 2014-09-02 | Corventis, Inc. | Patient monitoring systems and methods |
US9445719B2 (en) | 2008-12-15 | 2016-09-20 | Medtronic Monitoring, Inc. | Patient monitoring systems and methods |
US8233987B2 (en) | 2009-09-10 | 2012-07-31 | Respicardia, Inc. | Respiratory rectification |
US9999768B2 (en) | 2009-09-10 | 2018-06-19 | Respicardia, Inc. | Respiratory rectification |
US11883659B2 (en) | 2009-09-10 | 2024-01-30 | Zoll Respicardia, Inc. | Systems for treating disordered breathing by comparing stimulated and unstimulated breathing |
US20110060380A1 (en) * | 2009-09-10 | 2011-03-10 | Mark Gelfand | Respiratory rectification |
US11065443B2 (en) | 2009-09-10 | 2021-07-20 | Zoll Respicardia, Inc. | Respiratory rectification |
US9615757B2 (en) | 2009-10-22 | 2017-04-11 | Medtronic Monitoring, Inc. | Method and apparatus for remote detection and monitoring of functional chronotropic incompetence |
US8790259B2 (en) | 2009-10-22 | 2014-07-29 | Corventis, Inc. | Method and apparatus for remote detection and monitoring of functional chronotropic incompetence |
US10779737B2 (en) | 2009-10-22 | 2020-09-22 | Medtronic Monitoring, Inc. | Method and apparatus for remote detection and monitoring of functional chronotropic incompetence |
US9451897B2 (en) | 2009-12-14 | 2016-09-27 | Medtronic Monitoring, Inc. | Body adherent patch with electronics for physiologic monitoring |
US9173615B2 (en) | 2010-04-05 | 2015-11-03 | Medtronic Monitoring, Inc. | Method and apparatus for personalized physiologic parameters |
US8965498B2 (en) | 2010-04-05 | 2015-02-24 | Corventis, Inc. | Method and apparatus for personalized physiologic parameters |
US8585604B2 (en) | 2010-10-29 | 2013-11-19 | Medtronic, Inc. | Integrated patient care |
US11147476B2 (en) | 2010-12-07 | 2021-10-19 | Hill-Rom Services, Inc. | Monitoring a sleeping subject |
US10292625B2 (en) | 2010-12-07 | 2019-05-21 | Earlysense Ltd. | Monitoring a sleeping subject |
US20120157799A1 (en) * | 2010-12-20 | 2012-06-21 | Abhilash Patangay | Using device based sensors to classify events and generate alerts |
US8509902B2 (en) | 2011-07-28 | 2013-08-13 | Medtronic, Inc. | Medical device to provide breathing therapy |
US9861817B2 (en) | 2011-07-28 | 2018-01-09 | Medtronic, Inc. | Medical device to provide breathing therapy |
US20130197385A1 (en) * | 2012-01-31 | 2013-08-01 | Medtronic, Inc. | Respiratory function detection |
US11873266B2 (en) | 2012-05-08 | 2024-01-16 | Aeromics, Inc. | Methods of treating or controlling cytotoxic cerebral edema consequent to an ischemic stroke |
US11084778B2 (en) * | 2012-05-08 | 2021-08-10 | Aeromics, Inc. | Methods of treating cardiac edema, neuromyelitis optica, and hyponatremia |
US20140031643A1 (en) * | 2012-07-27 | 2014-01-30 | Cardiac Pacemakers, Inc. | Heart failure patients stratification |
US20170112409A1 (en) * | 2013-02-06 | 2017-04-27 | BTS S.p.A. | Wireless probe for dental electromyography |
US9295397B2 (en) | 2013-06-14 | 2016-03-29 | Massachusetts Institute Of Technology | Method and apparatus for beat-space frequency domain prediction of cardiovascular death after acute coronary event |
US9743889B2 (en) | 2013-08-05 | 2017-08-29 | Cardiac Pacemakers, Inc. | System and method for detecting worsening of heart failure based on rapid shallow breathing index |
US20150057555A1 (en) * | 2013-08-20 | 2015-02-26 | Sorin Crm Sas | Systems and methods for diagnosing heart failure based on sleep apneic indicators |
US9392950B2 (en) * | 2013-08-20 | 2016-07-19 | Sorin Crm Sas | Systems and methods for diagnosing heart failure based on sleep apneic indicators |
US11071744B2 (en) | 2013-11-06 | 2021-07-27 | Aeromics, Inc. | Prodrug salts |
US10894055B2 (en) | 2013-11-06 | 2021-01-19 | Aeromics, Inc. | Pharmaceutical compositions, methods of making pharmaceutical compositions, and kits comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}4-chlorophenyl dihydrogen phosphate |
US11801254B2 (en) | 2013-11-06 | 2023-10-31 | Aeromics, Inc. | Pharmaceutical compositions and methods of making pharmaceutical compositions comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate |
CN103800999A (en) * | 2014-02-25 | 2014-05-21 | 郑州雅晨生物科技有限公司 | Obstructive sleep apnea hypopnea syndrome therapeutic apparatus |
WO2016013684A1 (en) * | 2014-07-22 | 2016-01-28 | 帝人ファーマ株式会社 | Heart failure evaluation method and diagnosis device |
US11141070B2 (en) | 2014-07-22 | 2021-10-12 | Teijin Pharma Limited | Heart failure evaluation method and diagnosis device |
JPWO2016013684A1 (en) * | 2014-07-22 | 2017-04-27 | 帝人ファーマ株式会社 | Evaluation method and diagnostic device for heart failure |
US11497915B2 (en) | 2014-08-26 | 2022-11-15 | Rmx, Llc | Devices and methods for reducing intrathoracic pressure |
US10857363B2 (en) | 2014-08-26 | 2020-12-08 | Rmx, Llc | Devices and methods for reducing intrathoracic pressure |
US11812936B2 (en) | 2014-09-03 | 2023-11-14 | Hill-Rom Services, Inc. | Apparatus and methods for monitoring a sleeping subject |
US10945628B2 (en) * | 2015-08-11 | 2021-03-16 | Koninklijke Philips N.V. | Apparatus and method for processing electromyography signals related to respiratory activity |
US20180235503A1 (en) * | 2015-08-11 | 2018-08-23 | Koninklijke Philips N.V. | Apparatus and method for processing electromyography signals related to respiratory activity |
US11615891B2 (en) | 2017-04-29 | 2023-03-28 | Cardiac Pacemakers, Inc. | Heart failure event rate assessment |
WO2019189153A1 (en) * | 2018-03-26 | 2019-10-03 | テルモ株式会社 | Support system, support method, support program, and recording medium on which support program is recorded |
US11471683B2 (en) | 2019-01-29 | 2022-10-18 | Synapse Biomedical, Inc. | Systems and methods for treating sleep apnea using neuromodulation |
US11266838B1 (en) | 2019-06-21 | 2022-03-08 | Rmx, Llc | Airway diagnostics utilizing phrenic nerve stimulation device and method |
US11564626B2 (en) | 2019-08-26 | 2023-01-31 | Samsung Electronics Co., Ltd. | Implantable monitoring device and method of operating the implantable monitoring device |
CN114376559A (en) * | 2022-01-18 | 2022-04-22 | 高昌生医股份有限公司 | Respiration baseline tracking acceleration method |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20050085734A1 (en) | Heart failure patient treatment and management device | |
US7766840B2 (en) | Method and system for heart failure status evaluation based on a disordered breathing index | |
EP1938862B1 (en) | Disordered breathing management system and methods | |
US7899519B2 (en) | Evaluating a patient condition using autonomic balance information in implatable cardiac devices | |
EP1670547B1 (en) | Patient monitoring system | |
US8033998B2 (en) | Device and method for automatic threshold setting | |
US20060241708A1 (en) | Multiple sensors for sleep apnea with probability indication for sleep diagnosis and means for automatic activation of alert or therapy | |
US8540642B2 (en) | Implantable medical device and method for physiological event monitoring | |
US8043215B2 (en) | Drug titration utilizing an implantable medical device | |
US20210093254A1 (en) | Determining likelihood of an adverse health event based on various physiological diagnostic states | |
EP3796831B1 (en) | Sensing for heart failure management | |
US20240049968A1 (en) | Sensing for heart failure management | |
JP2022539525A (en) | Sensing for heart failure management |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: INSPIRATION MEDICAL, INC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:TEHRANI, AMIR J.;REEL/FRAME:015749/0058 Effective date: 20050110 |
|
AS | Assignment |
Owner name: RMX, L.L.C., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:INSPIRATION MEDICAL, INC.;REEL/FRAME:020266/0533 Effective date: 20070831 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |