US20050070990A1 - Medical devices and methods of making same - Google Patents
Medical devices and methods of making same Download PDFInfo
- Publication number
- US20050070990A1 US20050070990A1 US10/672,891 US67289103A US2005070990A1 US 20050070990 A1 US20050070990 A1 US 20050070990A1 US 67289103 A US67289103 A US 67289103A US 2005070990 A1 US2005070990 A1 US 2005070990A1
- Authority
- US
- United States
- Prior art keywords
- weight
- stent
- alloy
- mass
- weight percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C14/00—Alloys based on titanium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00035—Other metals or alloys
- A61F2310/00089—Zirconium or Zr-based alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00035—Other metals or alloys
- A61F2310/00095—Niobium or Nb-based alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00035—Other metals or alloys
- A61F2310/00101—Molybdenum or Mo-based alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00035—Other metals or alloys
- A61F2310/00131—Tantalum or Ta-based alloys
Definitions
- the invention relates to medical devices, such as, for example, stents and stent-grafts, and methods of making the devices.
- the body includes various passageways such as arteries, other blood vessels, and other body lumens. These passageways sometimes become occluded or weakened. For example, the passageways can be occluded by a tumor, restricted by plaque, or weakened by an aneurysm. When this occurs, the passageway can be reopened or reinforced, or even replaced, with a medical endoprosthesis.
- An endoprosthesis is typically a tubular member that is placed in a lumen in the body. Examples of endoprostheses include stents and covered stents, sometimes called “stent-grafts”.
- An endoprosthesis can be delivered inside the body by a catheter that supports the endoprosthesis in a compacted or reduced-size form as the endoprosthesis is transported to a desired site. Upon reaching the site, the endoprosthesis is expanded, for example, so that it can contact the walls of the lumen.
- MRI magnetic resonance imaging
- MRI uses a magnetic field and radio waves to image the body.
- the patient is exposed to a magnetic field, which interacts with certain atoms, e.g., hydrogen atoms, in the patient's body.
- Incident radio waves are then directed at the patient.
- the incident radio waves interact with atoms in the patient's body, and produce characteristic return radio waves.
- the return radio waves are detected by a scanner and processed by a computer to generate an image of the body.
- the invention features a system including a catheter for delivery into a body lumen.
- the catheter includes an expandable member and a stent as described herein disposable over the expandable member.
- the expandable member is expandable to a maximum diameter of about 1.55 mm to about 14 mm.
- the invention features an implantable medical device including an alloy having Ti at about 20 weight percent or more and at least one of Zr, Ta, or Mo, a yield strength of about 45 ksi or more, a magnetic susceptibility of about +1 or less, and a mass absorption coefficient of about 1.9 cm 2 /g or more.
- the medical device can be a filter, a guidewire, a catheter, a needle, a biopsy needle, a staple, or a cannula.
- the invention features a method of forming a medical device.
- the method includes providing a metal alloy of multiple components of elements or alloys, including a first component and a second component having a melting point difference of about 150° C. or more. Solid aliquots of the first component and the second component are contacted, heated and/or mechanically worked, then the worked components are melted. The alloy is incorporated into a medical device.
- the invention features a medical device including a titanium alloy having at least one of zirconium, tantalum, molybdenum, or niobium.
- the alloy exhibits radiopacity, MRI capability, mechanical properties, and/or biocompatibility properties, and combinations of the properties as described herein.
- the invention features particular alloys and techniques for making the alloys.
- Embodiments may include one or more of the following advantages.
- a stent or other medical device is provided that includes desirable magnetic imaging radiopacity, biocompatibility and/or mechanical characteristics.
- the stent is less susceptible to magnetic resonance image degradation (e.g., less than stainless steel) Implant movement or heating can be reduced.
- the stent alloy has sufficient radiopacity that the stent is visible by fluoroscopy.
- the mechanical characteristics of the alloy enable a stent of conventional design that can be delivered into the body in a reduced diameter configuration and then expanded at a treatment site, e.g., by a balloon catheter.
- the titanium alloys generally can exhibit enhanced strength, stiffness and radiopacity, while maintaining low magnetic susceptibility.
- FIGS. 1A and 1B are perspective views of a stent in a compressed and expanded condition, respectively.
- FIGS. 2A-2C illustrate delivery of a balloon expandable stent.
- FIG. 3 is a flow diagram of a stent manufacturing process.
- FIGS. 4A-4F illustrate a process for making a medical device.
- FIGS. 5-8 are photo micrographs.
- a stent 10 includes a metal body 12 in the shape of a tube.
- the metal body includes aperture regions 14 provided in a pattern to facilitate stent functions, such as radial expansion, and lateral flexibility. Between aperture regions are strut regions 16 .
- the stent 10 is provided or maintained in a relatively small diameter condition corresponding to a diameter D c .
- the stent 10 is expanded to a larger diameter, D exp , so that the stent is in contact with the lumen wall.
- the stent may be expanded by a mechanical expander, such as an inflatable balloon, or it may be self-expanding.
- the metal body of the stent may be formed by a generally continuous sheet or by filaments that are wrapped, braided, knitted or otherwise configured to generally define a stent.
- the stent 300 is carried on a catheter 302 over a balloon 304 .
- the balloon is expanded to expand the stent into contact with the lumen wall.
- the stent may be used in the vascular system (e.g., in the coronary or peripheral arteries), or in other body lumens.
- the stent body is formed of a metal alloy that has desirable magnetic resonance, radiopacity, biocompatibility, and/or mechanical characteristics.
- the alloy is a titanium-containing alloy that includes one or more of Zr, Ta or Mo.
- the alloy is formed from commercially pure (CP) titanium or Ti-6A1-4V ELI, which has been alloyed with one or more of Zr, Ta, or Mo by processes that include mechanical or diffusion alloying followed by melting, as will be described below.
- the alloy is formulated to provide desired characteristics.
- the alloy is formulated to reduce signal distortion, electrical current (e.g., eddy current) generation, heating, movement within the body or nerve simulation, by controlling the magnetic susceptibility and solubility of the alloy constituents.
- the magnetic susceptibilities of Ti, Zr, Ta, and Mo and other materials are provided in Table I. TABLE I Magnetic Susceptibilities Material: Magnetic Susceptibility: Water at 37° C.
- the magnetic susceptibility of the alloy is less than the magnetic susceptibility of austenitic stainless steel, e.g. about +1 or less or about 3.5 ⁇ 10 ⁇ 3 or less.
- Solubility of the constituents can be determined by binary phase diagrams. Suitable solubility is indicated by a single phase (alpha or beta) or by a two phase solution (alpha and beta) at room temperature. Examples of suitable phase diagrams are available in the ASM Handbook, volume 3, ASM International, 1992, the entire contents of which is hereby incorporated by reference.
- the alloy is formulated to a desired mass absorption coefficient.
- the stent is readily visible by fluoroscopy, but does not appear so bright that detail in the fluoroscopic image is distorted.
- the alloy or the device has a radiopacity of from about 1.10 to about 3.50 times (e.g., greater than or equal to about 1.1, 1.5, 2.0, 2.5, or 3.0 times; and/or less than or equal to about 3.5, 3.0, 2.5, 2.0, or 1.5 times) that of 316L grade stainless steel, as measured by ASTM F640 (Standard Test Methods for Radiopacity of Plastics for Medical Use).
- Mass absorption coefficients and densities or Ti, Ta, Zr and Mo are compared to 316L stainless steel in Table II. TABLE II Mass Absorption Coefficients Alloy 316L SS Ti Ta Zr Mo Mass absorption 1.96 (Fe) 1.21 5.72 6.17 7.04 coefficient, cm 2 /g Density, g/cc 8.0 4.5 16.7 6.5 10.2
- the mass absorption coefficient of the alloy is about 1.96 cm 2 /g (corresponding substantially to the mass absorption coefficient of Fe) to about 2.61 cm 2 /g (corresponding to about 0.5 the mass absorption coefficient of Ta).
- Mass absorption coefficient can be calculated from the results of radiopacity tests, as described in The Physics of Radiology, H. E. Johns, J. R. Cunningham, Charles C. Thomas Publisher, 1983, Springfield, Ill., pp. 133-143. A calculation of alloy mass absorption coefficient is provided in the examples, infra.
- the alloy is formulated based on solubility and phase structure.
- the alloy exhibits certain mechanical properties within about ⁇ 20% (e.g., within about ⁇ 10%, about ⁇ 5%, or about ⁇ 1%) of the corresponding value for stainless steel.
- Mechanical properties for select materials are provided in Table III. TABLE III Mean Tensile Test Data (Annealed Condition) 0.2% offset % strain UTS, % strain to E, Tubing Ys, ksi to peak load ksi fracture msi 316L SS 50 36 94 45 29 Tantalum 24 No data 35-70 40 27 CP Titanium 25-70 No data 35-80 15-25 15 Ti—6Al—4V 120 No data 130 15 17 ELI
- Yield strength relates to the applied pressure needed to flow the alloy to expand the stent.
- the percent strain to peak load indicates how far the material can strain before necking occurs.
- the ultimate tensile strength (UTS) is the stress value that corresponds with strain to peak load.
- the percent strain to fracture is a measure of how far the material can be stretched prior to break, and includes uniform deformation plus location deformation in the necked down region. This property relates to stent strut fracture from over-expansion of the stent. Suitable test methods for determining these parameters are described in ASTM E8 (Standard Test Methods for Tension Testing of Metallic Materials). In Table III, the 316L SS properties were measured from annealed stent tubing. The other material properties were taken from handbooks, such as American Society for Metals Handbook Desk Edition, H. E. Boyer, T. L. Gall, 1985.
- phase diagrams The solubility of the constituents and phase structure of the alloy is indicated by phase diagrams. Suitable solubilities are indicated by alpha and/or beta microstructures without substantial amounts of more brittle phases such as alpha prime, alpha double prime or omega phases. Active rapid cooling after melting can be utilized to reduce precipitation of these phases.
- the presence of brittle phases is less than about 10% (e.g., less than about 7%, 5%, or 3%) as measured by X-ray diffraction analysis.
- the presence of two phases is preferably equal to or less than the amount in commercially available Ti-6A1-4V (available from Allegheny Technologies Allvac (Monroe, N.C.) or Metalmen Sales (Long Island City, N.Y.).
- Alloying Ti with Ta and Mo increases modulus of elasticity. Alloying Ti with Ta, Mo, and/or Zr increases tensile strength. In embodiments, tensile properties are balanced by annealing the alloy. For example, annealing time and temperature can be selected to produce a maximum level of ductility while meeting minimum design requirements for yield strength and grain size. Alternatively or in addition, the stent design can be modified to accommodate less favorable mechanical properties.
- the stent is designed to lower the strain on the struts during expansion, such as by increasing the number of deformation “hinge” points in the stent so that the total stent deformation is distributed in smaller amounts to the areas where deformation occurs.
- Biocompatibility of the stent is provided by alloying biocompatible constituents or coating the sent with a biocompatible material. Biocompatibility can be tested by using industry standard ISO 10992 in-vitro and in vivo test methods, which can provide a qualitative pass or fail indication.
- the stent has a biocompatibility similar to or equivalent to pure titanium or pure tantalum, as measured by ISO 10992 test methods.
- the alloy constituents are provided in combinations and amounts recited in the Summary and Examples.
- the alloy is Ti-Ta, Ti-Mo, Ti-Zr, Ti-Ta-Mo, Ti-Ta-Zr, Ti-Ta-Zr-Mo, Ti-Zr-Mo or Ti 6A1-4V-Ta, Ti 6A1-4V-Mo, Ti 6A1-4V-Zr, Ti 6A1-4V-Ta-Mo, Ti 6A1-4V-Ta-Zr, Ti 6A1-4V-Ta-Zr-Mo, or Ti 6A1-4V-Zr-Mo alloy.
- Ti-13Nb-13Zr, Ti-8A1-1Mo-1V, Ti-6A1-2Nb-1 Ta-0.8Mo and Ti-7A1-4Mo one alloyed with Ta, Mo, and/or Zr.
- the alloy is annealed.
- the alloy is formed by alloying CP titanium or Ti-6A1-4V ELI with Ta, Zr and/or Mo.
- the alloy includes 40 to 70 weight percent tantalum or 25 to 50 weight percent zirconium with CP titanium or Ti-6A1-4V ELI.
- 5 to 20 weight percent molybdenum is added in place of some of the titanium for added tensile strength without sacrificing MRI compatibility.
- Suitable alloys include the following: CP Titanium alloyed with: Ti—6Al—4V ELI alloyed with: 43 weight % Ta 43 weight % Ta 69 weight % Ta 69 weight % Ta 25 weight % Ta 25 weight % Ta 49 weight % Zr 49 weight % Zr 43 weight % Ta + 5% Mo 43 weight % Ta + 5% Mo 69 weight % Ta + 5% Mo 69 weight % Ta + 5% Mo 25 weight % Zr + 5% Mo 25 weight % Zr + 5% Mo 49 weight % Zr + 5% Mo 49 weight % Zr + 5% Mo 49 weight % Zr + 5% Mo 43 weight % Ta + 10% Mo 43 weight % Ta + 10% Mo 69 weight % Ta + 10% Mo 69 weight % Ta + 10% Mo 25 weight % Zr + 10% Mo 25 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 49 weight
- a stent is constructed by forming an alloy, forming a tube from the alloy, and then forming the tube into a stent.
- an alloying process is illustrated for forming an ingot or billet of a size and form suitable for stent construction.
- a base rod 60 and one or more additive rods 62 are provided.
- the base rod is Ti or a Ti-containing alloy and the additive rod(s) are Ti, Ta, Zr, and/or Mo.
- the weight of the rods are in proportion to the desired alloy formulation.
- the base rod is drilled to provide voids 64 .
- additive rods 62 are inserted into the voids 64 of the base rod 60 .
- this assembly is prealloyed by heating and/or mechanically working to cause diffusion alloying between constituents.
- the alloy e.g., the alloyed billet is suitable for further processing.
- the billet can be drawn into tubing or rolled into a sheet for stock stent tubing production.
- an ingot or billet 2.5 inches in diameter by 4 inches long can typically yield at least 1000 feet of coronary stent tubing.
- the alloying process is particularly advantageous for alloying constituents with large melting temperature differences.
- Table IV the melting temperatures of Ti, Ta, Zr, and Mo are provided. TABLE IV Melting Temperatures Element Melting Temperature, ° C. Ti 1668 Ta 2996 Zr 1852 Mo 2610
- the prelloying step heating is performed in an inert gas or vacuum, or the outer surfaces of the billet could be coated or canned with a protective metal, such as iron, that could later be chemically dissolved.
- the billet can also be extruded, drawn, or rolled to further consolidate the assembly.
- the heat treatment or working serves to hold additive material in place within the billet during melting.
- constituents with high melting points can be essentially encapsulated within, e.g. titanium, minimizing the exposure to any residual air in the casting furnace.
- the assembly can be heated near the melting temperature of the lowest melting temperature constituent and/or the melting temperature of the material of the base rod. For example, for a Ti base rod, the temperature is about 1600° C. or less.
- additives to the base are made in incremental steps in each of multiple melting and ingot casting operations.
- the Ti-6A1 -4V bar holes may be filled with 22 weight percent tantalum.
- holes are drilled again and filled with another 22 weight percent tantalum and the melting is repeated.
- Other sequences and magnitudes of Ta adds are made to reach the final alloy with 43 weight percent Ta.
- This approach is Ta elemental segregation in the ingot if it is added in smaller amounts in multiple melting and ingot casting steps.
- homogenization heat treatments between melts can reduce the amount of elemental diffusion needed.
- the additive can be provided in the form of powder or chips rather than a solid wire or rod.
- the alloying that occurs in the melting and ingot casting process can be further improved by performing a homogenization (elemental diffusion) heat treatment to the ingots between melting operations.
- Mechanical alloying melting, casting, and heat treating operations can be performed at commercial sources such as Pittsburgh Materials Technology Inc. (Pittsburgh, Pa.), Applegate Group (Woodcliff Lake, N.J.) or Albany Research Center (Albany, Ore.).
- the alloy tubing is formed into stent.
- selected portions can be removed to define bands and struts.
- the portions can be removed by laser cutting, as described, for example, in U.S. Pat. No. 5,780,807.
- a liquid carrier such as a solvent, gas, or an oil
- the carrier can prevent drops formed on one portion from re-depositing on another portion, and/or reduce formation of recast material on the tubular member.
- Other methods of removing portions of tubular member include mechanical machining (e.g., micro-machining), electrical discharge machining (EDM), photoetching (e.g., acid photoetching), and/or chemical etching.
- the stent can further be finished, e.g., electropolished to a smooth finish, according to conventional methods.
- about 0.0001 inch of material can be removed from the interior and/or exterior surfaces by chemical milling and/or electropolishing.
- the stent can be annealed to refine the mechanical and physical properties of the stent.
- the stent can be used, e.g., delivered and expanded, using a catheter.
- Suitable catheter systems are described in, for example, Wang U.S. Pat. No. 5,195,969, and Hamlin U.S. Pat. No. 5,270,086.
- Suitable stents and stent delivery are also exemplified by the Express, Radius® or Symbio® systems, available from Boston Scientific Scimed, Maple Grove, Minn.
- the stent can be of any desired shape and size (e.g., coronary stents, aortic stents, peripheral vascular stents, gastrointestinal stents, urology stents, and neurology stents).
- the stent can have a diameter of between, for example, 1 mm to 46 mm.
- a coronary stent can have an expanded diameter of from about 2 mm to about 6 mm.
- a peripheral stent can have an expanded diameter of from about 5 mm to about 24 mm.
- a gastrointestinal and/or urology stent can have an expanded diameter of from about 6 mm to about 30 mm.
- a neurology stent can have an expanded diameter of from about 1 mm to about 12 mm.
- An abdominal aortic aneurysm (AAA) stent and a thoracic aortic aneurysm (TAA) stent can have a diameter from about 20 mm to about 46 mm.
- Stent 100 can be balloon-expandable, self-expandable, or a combination of both (e.g., U.S. Pat. No. 5,366,504).
- the stent can also be a part of a stent-graft.
- the stent includes and/or be attached to a biocompatible, non-porous or semi-porous polymer matrix made of polytetrafluoroethylene (PTFE), expanded PTFE, polyethylene, urethane, or polypropylene.
- PTFE polytetrafluoroethylene
- the endoprosthesis can include a releasable therapeutic agent, drug, or a pharmaceutically active compound, such as described in U.S. Pat. No. 5,674,242, U.S. Ser. No. 09/895,415, filed Jul. 2, 2001 and U.S. Ser. No. 10/232,265, filed Aug. 30, 2002.
- the therapeutic agents, drugs, or pharmaceutically active compounds can include, for example, anti-thrombogenic agents, antioxidants, anti-inflammatory agents, anesthetic agents, anti-coagulants, and antibiotics.
- the methods and the embodiments described above can be used to form medical devices other than stents and stent-grafts.
- the methods and/or materials can be used to form filters, such as removable thrombus filters described in Kim et al., U.S. Pat. No. 6,146,404; in intravascular filters such as those described in Daniel et al., U.S. Pat. No. 6,171,327; and in vena cava filters such as those described in Soon et al., U.S. Pat. No. 6,342,062.
- the methods and/or materials can be used to form guidewires, such as a Meier steerable guidewire.
- the methods and/or materials can be used to form vaso-occlusive devices, e.g., coils, used to treat intravascular aneurysms, as described, e.g., in Bashiri et al., U.S. Pat. No. 6,468,266, and Wallace et al., U.S. Pat, No. 6,280,457.
- the methods and/or materials can be used to form wire to make catheter reinforcement braid.
- the methods and/or materials can also be used in surgical instruments, such as forceps, needles, clamps, and scalpels.
- a titanium-tantalum alloy with a mass absorption coefficient of at least 1.96 cm 2 /g (iron) and as high as 2.86 cm 2 /g (half of tantalum) is formulated as follows.
- the atomic mass coefficient for titanium is 1.21 and for tantalum is 5.72.
- An alloy of 83 atomic percent Ti and 17 atomic percent Ta has a calculated mass absorption coefficient equivalent to iron and a radiopacity similar to 316L stainless steel.
- An alloy of 63 atomic percent Ti and 37 atomic percent Ta has a calculated mass absorption coefficient equivalent to one-half of tantalum.
- the alloy constituents have magnetic susceptibility less than 3.5 ⁇ 10 ⁇ 3 and are soluble in each other.
- the tantalum-titanium binary phase diagram (ASM Handbook, Volume 3 Alloy Phase Diagrams, ASM International, 1992, p.
- tantalum-titanium binary phase diagram indicates that the alloys with 43 to 69 percent tantalum concentration have alpha and beta phase microstructures. No brittle phases are evident in the phase diagram.
- a titanium-molybdenum alloy with a mass absorption coefficient of at least 1.96 cm 2 /g (iron) and as high as 2.86 cm 2 /g (halfoftantalum) is formulated as follows.
- An alloy of 87 atomic percent Ti and 13 atomic percent mo (77 weight percent Ti and 23 weight percent Mo) has a calculated mass absorption coefficient equivalent to iron and a radiopacity similar to 316L stainless steel.
- An alloy of 72 atomic percent Ti and 28 atomic percent Mo (56 weight percent Ti and 44 weight percent Mo) has a calculated mass absorption coefficient equivalent to one-half of tantalum and therefore has half the radiopacity of tantalum.
- the alloy constituents have magnetic susceptibility less than 3.5 ⁇ 10 ⁇ 3 and that are soluble in each other.
- the molybdenum titanium binary phase diagram indicates (ASM Handbook, Volume 3 Alloy Phase Diagrams, ASM International, 1992, p.2.296) 23 to 44 weight percent molybdenum to be soluble in titanium as a solid solution single (beta) or two-phase (alpha and beta) material at room temperature.
- the molybdenum-titanium binary phase diagram also indicates that alloys with 23 to 44 percent molybdenum concentration will have beta or beta plus alpha phase microstructures which are common in commercialized titanium engineering alloys such as Ti-6A1-4V. Cooling through the temperature range of about 850 to 695° C. can be performed rapidly (e.g., by argon gas, air cool, or liquid quenchant) to avoid precipitation of significant amounts of alpha-prime, alpha-double prime, or omega phases.
- a method for making an alloy of Ti-6A1-4V ELI with 43 weight percent Ta follows.
- Procure a 3′′ diameter round bar of Ti-6A1-4V ELI (such as form Titanium Industries, Inc. in Morristown, N.J.) and cut to 5.5 inches long.
- Procure 0.5′′ diameter tantalum rod (such as from Rembar, Dobbs Ferry, N.Y.) and cut into lengths of 3.25′′.
- Drill eight holes into the titanium bar that are 0.55/0.6′′ diameter and 4.5′′ deep. Put the eight 3.25′′ long pieces of 0.5′′ diameter tantalum rod into the holes. Heat the assembly in a vacuum furnace at 1400° C. for 8 hours and vacuum cool. Gas tungsten arc weld (GTAW or TIG) the assembly with the hole-end up to the vacuum arc remelt (VAR) electrode holder.
- GTAW or TIG Gas tungsten arc weld
- Arc melted Ti-Ta alloy button ingots were prepared. Two ingots were melted from a 50-50 mixture (by weight) of Ti-6A1-4V and tantalum rods. One ingot was melted from a 50-50 mixture (by weight) of pure titanium and tantalum rods. Cold rolling and annealing of the ingots were used to form strips for mechanical and physical property testing.
- the ingots were prepared from the following rods and charge materials procured from Goodfellow Corporation, Berwyn, Pa. TABLE V Rods Material Traceability Ti—6Al—4V Goodfellow LS251817JV; TI017910/1, 5 mm dia ⁇ rods 200 mm long rods, 10 pcs, 174 g, annealed Ta rods Goodfellow LS251817JV, TA007920/8, 99.9% pure, 2 mm dia ⁇ 200 mm long rods, 5 pcs, 53.2 g, annealed Ti rods Goodfellow LS251817JV, TI007910/12, 2 mm dia ⁇ 100 mm long rods, 20 pcs, 28.5 g, 99.6% pure, annealed
- Strip #1 had fine edge cracks.
- Strip #2 had no cracks.
- Strip #3 had edge cracks.
- the cold rolled strips were annealed in the vacuum heat treat furnace at 1000° C. for 30 minutes in vacuum followed by a vacuum cool. The purpose of this heat treatment was to recrystallize the cold worked microstructure and soften the material to allow further cold rolling.
- the strips were cold rolled to 0.025′′ thickness. The dimensions are given in Table X. TABLE X Dimension of Strips After Third Cold Rolling Campaign Bar # Length, inches Width, inches Thickness, inches 1 (Ti—Ta) 9 and 8 079 0.025 2 (Ti64—Ta) 10 0.88 0.025 3 (Ti64—Ta) 6 0.65 0.025
- Strips #1 and #3 had many small edge cracks. Strip #2 did not have edge cracks.
- the strips were beta solution treated in a vacuum heat treat furnace at 850° C. for 30 minutes and cooled in vacuum.
- the strips were submitted for metallography.
- the strips were subjected to tensile specimen machining and testing (Metcut Research Associates, Inc. (Cincinnati, Ohio)).
- the tensile results were 85-115 ksi UTS, 65-105 YS, and 5-25% elongation.
Abstract
Description
- The invention relates to medical devices, such as, for example, stents and stent-grafts, and methods of making the devices.
- The body includes various passageways such as arteries, other blood vessels, and other body lumens. These passageways sometimes become occluded or weakened. For example, the passageways can be occluded by a tumor, restricted by plaque, or weakened by an aneurysm. When this occurs, the passageway can be reopened or reinforced, or even replaced, with a medical endoprosthesis. An endoprosthesis is typically a tubular member that is placed in a lumen in the body. Examples of endoprostheses include stents and covered stents, sometimes called “stent-grafts”.
- An endoprosthesis can be delivered inside the body by a catheter that supports the endoprosthesis in a compacted or reduced-size form as the endoprosthesis is transported to a desired site. Upon reaching the site, the endoprosthesis is expanded, for example, so that it can contact the walls of the lumen.
- When the endoprosthesis is advanced through the body, its progress can be monitored, e.g., tracked, so that the endoprosthesis can be delivered properly to a target site. After the endoprosthesis is delivered to the target site, the endoprosthesis can be monitored to determine whether it has been placed properly and/or is functioning properly.
- Monitoring of the position of the endoprosthesis during implantation is typically performed by a radiographic technique such as fluoroscopy. The radiographic density of the metal endoprosthesis is different from bone and tissue, and the device is observed in the fluoroscopic image from the visible difference in contrast and grey scale relative to the surrounding biological material. The disadvantage of fluoroscopy is that the physician, staff, and patient are exposed to ionizing radiation which can be harmful in strong or repeated doses.
- Another method of monitoring a medical device is magnetic resonance imaging (MRI). MRI uses a magnetic field and radio waves to image the body. In some MRI procedures, the patient is exposed to a magnetic field, which interacts with certain atoms, e.g., hydrogen atoms, in the patient's body. Incident radio waves are then directed at the patient. The incident radio waves interact with atoms in the patient's body, and produce characteristic return radio waves. The return radio waves are detected by a scanner and processed by a computer to generate an image of the body.
- In an aspect, the invention features a balloon-expandable medical stent. The stent includes a generally tubular body including an alloy having Ti at about 20 weight percent or more and at least one of Zr, Ta, or Mo. The alloy has a yield strength of about 45 ksi or more, a magnetic susceptibility of about +1 or less, and a mass absorption coefficient of about 1.9 cm2/g or more.
- In another aspect, the invention features a system including a catheter for delivery into a body lumen. The catheter includes an expandable member and a stent as described herein disposable over the expandable member. The expandable member is expandable to a maximum diameter of about 1.55 mm to about 14 mm.
- In another aspect, the invention features an implantable medical device including an alloy having Ti at about 20 weight percent or more and at least one of Zr, Ta, or Mo, a yield strength of about 45 ksi or more, a magnetic susceptibility of about +1 or less, and a mass absorption coefficient of about 1.9 cm2/g or more. The medical device can be a filter, a guidewire, a catheter, a needle, a biopsy needle, a staple, or a cannula.
- In another aspect, the invention features a method of forming a stent. The method includes providing an alloy including Ti of about 20 weight percent or more and at least one of an additive selected from Zr, Ta or Mo. The method includes contacting solid aliquots of a titanium component selected from Ti or a Ti-containing alloy, and the additive heating the aliquot after the contacting, and mechanically working the aliquots after contacting by forging, extrusion, drawing or rolling, melting the aliquots, forming an ingot, forming a tube including the alloy, and incorporating the tube into a stent.
- In an aspect, the invention features a method of forming a medical device. The method includes providing a metal alloy of multiple components of elements or alloys, including a first component and a second component having a melting point difference of about 150° C. or more. Solid aliquots of the first component and the second component are contacted, heated and/or mechanically worked, then the worked components are melted. The alloy is incorporated into a medical device.
- In another aspect, the invention features a medical device including an alloy that exhibits one or more (e.g., two, three, or four) properties selected from radiopacity, MRI capability, mechanical properties, and/or biocompatibility properties as described herein, in any combination. In other aspects, the invention features particular alloys and techniques for making the alloys.
- In yet another aspect, the invention features a medical device including a titanium alloy having at least one of zirconium, tantalum, molybdenum, or niobium. The alloy exhibits radiopacity, MRI capability, mechanical properties, and/or biocompatibility properties, and combinations of the properties as described herein. In other aspects, the invention features particular alloys and techniques for making the alloys.
- Embodiments may include one or more of the following advantages. A stent or other medical device is provided that includes desirable magnetic imaging radiopacity, biocompatibility and/or mechanical characteristics. For example, the stent is less susceptible to magnetic resonance image degradation (e.g., less than stainless steel) Implant movement or heating can be reduced. The stent alloy has sufficient radiopacity that the stent is visible by fluoroscopy. The mechanical characteristics of the alloy enable a stent of conventional design that can be delivered into the body in a reduced diameter configuration and then expanded at a treatment site, e.g., by a balloon catheter. The titanium alloys generally can exhibit enhanced strength, stiffness and radiopacity, while maintaining low magnetic susceptibility.
- Still further aspects, features, and advantages follow.
-
FIGS. 1A and 1B are perspective views of a stent in a compressed and expanded condition, respectively. -
FIGS. 2A-2C illustrate delivery of a balloon expandable stent. -
FIG. 3 is a flow diagram of a stent manufacturing process. -
FIGS. 4A-4F illustrate a process for making a medical device. -
FIGS. 5-8 are photo micrographs. -
- Structure and Alloy Formulation
- Referring to
FIGS. 1A and 1B , astent 10 includes ametal body 12 in the shape of a tube. The metal body includesaperture regions 14 provided in a pattern to facilitate stent functions, such as radial expansion, and lateral flexibility. Between aperture regions are strut regions 16. Referring particularly to FIG 1A, for delivery into the body, thestent 10 is provided or maintained in a relatively small diameter condition corresponding to a diameter Dc. Referring to FIG 1B, upon placement at the treatment site, thestent 10 is expanded to a larger diameter, Dexp, so that the stent is in contact with the lumen wall. The stent may be expanded by a mechanical expander, such as an inflatable balloon, or it may be self-expanding. The metal body of the stent may be formed by a generally continuous sheet or by filaments that are wrapped, braided, knitted or otherwise configured to generally define a stent. - Referring now to
FIGS. 2A-2C , the delivery of a balloon-expandable stent is illustrated. Thestent 300 is carried on acatheter 302 over aballoon 304. When the treatment site is reached, the balloon is expanded to expand the stent into contact with the lumen wall. The stent may be used in the vascular system (e.g., in the coronary or peripheral arteries), or in other body lumens. - The stent body is formed of a metal alloy that has desirable magnetic resonance, radiopacity, biocompatibility, and/or mechanical characteristics. In embodiments, the alloy is a titanium-containing alloy that includes one or more of Zr, Ta or Mo. In particular embodiments, the alloy is formed from commercially pure (CP) titanium or Ti-6A1-4V ELI, which has been alloyed with one or more of Zr, Ta, or Mo by processes that include mechanical or diffusion alloying followed by melting, as will be described below.
- The alloy is formulated to provide desired characteristics. For MRI compatibility, the alloy is formulated to reduce signal distortion, electrical current (e.g., eddy current) generation, heating, movement within the body or nerve simulation, by controlling the magnetic susceptibility and solubility of the alloy constituents. The magnetic susceptibilities of Ti, Zr, Ta, and Mo and other materials are provided in Table I.
TABLE I Magnetic Susceptibilities Material: Magnetic Susceptibility: Water at 37° C. −9.05 × 10−6 Human tissues −11.0 × 10−6 to −7.0 × 10−6 copper −9.63 × 10−6 ferromagnetic iron +105 magnetic stainless steel (martensitic) +103 stainless steel (austenitic) +3.5 × 10−3 to +6.7 × 10−3 heavily cold worked stainless steel +1 to +10 (austenitic) Nitinol (Ni—Ti) +0.245 × 10−3 zirconium +0.109 × 10−3 titanium +0.182 × 10−3 niobium +0.237 × 10−3 platinum +0.279 × 10−3 molybdenum +0.123 × 10−3 tantalum +0.178 × 10−3 - In embodiments, the magnetic susceptibility of the alloy is less than the magnetic susceptibility of austenitic stainless steel, e.g. about +1 or less or about 3.5×10−3 or less. Solubility of the constituents can be determined by binary phase diagrams. Suitable solubility is indicated by a single phase (alpha or beta) or by a two phase solution (alpha and beta) at room temperature. Examples of suitable phase diagrams are available in the ASM Handbook, volume 3, ASM International, 1992, the entire contents of which is hereby incorporated by reference.
- For radiopacity, the alloy is formulated to a desired mass absorption coefficient. Preferably, the stent is readily visible by fluoroscopy, but does not appear so bright that detail in the fluoroscopic image is distorted. In some embodiments, the alloy or the device has a radiopacity of from about 1.10 to about 3.50 times (e.g., greater than or equal to about 1.1, 1.5, 2.0, 2.5, or 3.0 times; and/or less than or equal to about 3.5, 3.0, 2.5, 2.0, or 1.5 times) that of 316L grade stainless steel, as measured by ASTM F640 (Standard Test Methods for Radiopacity of Plastics for Medical Use). Mass absorption coefficients and densities or Ti, Ta, Zr and Mo are compared to 316L stainless steel in Table II.
TABLE II Mass Absorption Coefficients Alloy 316L SS Ti Ta Zr Mo Mass absorption 1.96 (Fe) 1.21 5.72 6.17 7.04 coefficient, cm2/g Density, g/cc 8.0 4.5 16.7 6.5 10.2 - In embodiments, the mass absorption coefficient of the alloy is about 1.96 cm2/g (corresponding substantially to the mass absorption coefficient of Fe) to about 2.61 cm2/g (corresponding to about 0.5 the mass absorption coefficient of Ta). Mass absorption coefficient can be calculated from the results of radiopacity tests, as described in The Physics of Radiology, H. E. Johns, J. R. Cunningham, Charles C. Thomas Publisher, 1983, Springfield, Ill., pp. 133-143. A calculation of alloy mass absorption coefficient is provided in the examples, infra.
- For desirable mechanical properties, the alloy is formulated based on solubility and phase structure. In particular embodiments, the alloy exhibits certain mechanical properties within about ±20% (e.g., within about ±10%, about ±5%, or about ±1%) of the corresponding value for stainless steel. Mechanical properties for select materials are provided in Table III.
TABLE III Mean Tensile Test Data (Annealed Condition) 0.2% offset % strain UTS, % strain to E, Tubing Ys, ksi to peak load ksi fracture msi 316L SS 50 36 94 45 29 Tantalum 24 No data 35-70 40 27 CP Titanium 25-70 No data 35-80 15-25 15 Ti—6Al—4V 120 No data 130 15 17 ELI - Yield strength (YS) relates to the applied pressure needed to flow the alloy to expand the stent. The percent strain to peak load indicates how far the material can strain before necking occurs. The ultimate tensile strength (UTS) is the stress value that corresponds with strain to peak load. The percent strain to fracture is a measure of how far the material can be stretched prior to break, and includes uniform deformation plus location deformation in the necked down region. This property relates to stent strut fracture from over-expansion of the stent. Suitable test methods for determining these parameters are described in ASTM E8 (Standard Test Methods for Tension Testing of Metallic Materials). In Table III, the 316L SS properties were measured from annealed stent tubing. The other material properties were taken from handbooks, such as American Society for Metals Handbook Desk Edition, H. E. Boyer, T. L. Gall, 1985.
- The solubility of the constituents and phase structure of the alloy is indicated by phase diagrams. Suitable solubilities are indicated by alpha and/or beta microstructures without substantial amounts of more brittle phases such as alpha prime, alpha double prime or omega phases. Active rapid cooling after melting can be utilized to reduce precipitation of these phases. In embodiments, the presence of brittle phases is less than about 10% (e.g., less than about 7%, 5%, or 3%) as measured by X-ray diffraction analysis. The presence of two phases is preferably equal to or less than the amount in commercially available Ti-6A1-4V (available from Allegheny Technologies Allvac (Monroe, N.C.) or Metalmen Sales (Long Island City, N.Y.). Alloying Ti with Ta and Mo increases modulus of elasticity. Alloying Ti with Ta, Mo, and/or Zr increases tensile strength. In embodiments, tensile properties are balanced by annealing the alloy. For example, annealing time and temperature can be selected to produce a maximum level of ductility while meeting minimum design requirements for yield strength and grain size. Alternatively or in addition, the stent design can be modified to accommodate less favorable mechanical properties. For example, for a lower tensile elongation (% strain to fracture) the stent is designed to lower the strain on the struts during expansion, such as by increasing the number of deformation “hinge” points in the stent so that the total stent deformation is distributed in smaller amounts to the areas where deformation occurs.
- Biocompatibility of the stent is provided by alloying biocompatible constituents or coating the sent with a biocompatible material. Biocompatibility can be tested by using industry standard ISO 10992 in-vitro and in vivo test methods, which can provide a qualitative pass or fail indication. In embodiments, the stent has a biocompatibility similar to or equivalent to pure titanium or pure tantalum, as measured by ISO 10992 test methods.
- In embodiments, the alloy constituents are provided in combinations and amounts recited in the Summary and Examples. In particular embodiments, the alloy is Ti-Ta, Ti-Mo, Ti-Zr, Ti-Ta-Mo, Ti-Ta-Zr, Ti-Ta-Zr-Mo, Ti-Zr-Mo or Ti 6A1-4V-Ta, Ti 6A1-4V-Mo, Ti 6A1-4V-Zr, Ti 6A1-4V-Ta-Mo, Ti 6A1-4V-Ta-Zr, Ti 6A1-4V-Ta-Zr-Mo, or Ti 6A1-4V-Zr-Mo alloy. In other embodiments, Ti-13Nb-13Zr, Ti-8A1-1Mo-1V, Ti-6A1-2Nb-1 Ta-0.8Mo and Ti-7A1-4Mo one alloyed with Ta, Mo, and/or Zr. In particular embodiments, the alloy is annealed. In particular embodiments, the alloy is formed by alloying CP titanium or Ti-6A1-4V ELI with Ta, Zr and/or Mo. In embodiments, the alloy includes 40 to 70 weight percent tantalum or 25 to 50 weight percent zirconium with CP titanium or Ti-6A1-4V ELI. In embodiments, 5 to 20 weight percent molybdenum is added in place of some of the titanium for added tensile strength without sacrificing MRI compatibility. Suitable alloys include the following:
CP Titanium alloyed with: Ti—6Al—4V ELI alloyed with: 43 weight % Ta 43 weight % Ta 69 weight % Ta 69 weight % Ta 25 weight % Ta 25 weight % Ta 49 weight % Zr 49 weight % Zr 43 weight % Ta + 5% Mo 43 weight % Ta + 5% Mo 69 weight % Ta + 5% Mo 69 weight % Ta + 5% Mo 25 weight % Zr + 5% Mo 25 weight % Zr + 5% Mo 49 weight % Zr + 5% Mo 49 weight % Zr + 5% Mo 43 weight % Ta + 10% Mo 43 weight % Ta + 10% Mo 69 weight % Ta + 10% Mo 69 weight % Ta + 10% Mo 25 weight % Zr + 10% Mo 25 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 49 weight % Zr + 10% Mo 22 weight % Ta + 13% Zr 22 weight % Ta + 13% Zr 35 weight % Ta + 25% Zr 35 weight % Ta + 25% Zr - Manufacture
- Referring to
FIG. 3 , a stent is constructed by forming an alloy, forming a tube from the alloy, and then forming the tube into a stent. - Referring to
FIGS. 4A to 4E, an alloying process is illustrated for forming an ingot or billet of a size and form suitable for stent construction. - Referring to
FIG. 4A , abase rod 60 and one or moreadditive rods 62 are provided. For example, the base rod is Ti or a Ti-containing alloy and the additive rod(s) are Ti, Ta, Zr, and/or Mo. The weight of the rods are in proportion to the desired alloy formulation. - Referring to
FIG. 4B , the base rod is drilled to providevoids 64. - Referring to
FIG. 4C ,additive rods 62 are inserted into thevoids 64 of thebase rod 60. - Referring to
FIG. 4D , this assembly is prealloyed by heating and/or mechanically working to cause diffusion alloying between constituents. - Referring to
FIG. 4E , the assembly is provided with end caps to preventadditive rods 62 from falling out ofbase rod 60. The assembly is melted and cast once or multiple times in a vacuum are remelt (VAR) furnace, EB melting furnace, VIM furnace, or levitation melting furnace to allow liquid-phase alloying to occur. - Referring to
FIG. 4F , the alloy (e.g., the alloyed billet is suitable for further processing. The billet can be drawn into tubing or rolled into a sheet for stock stent tubing production. For example an ingot or billet 2.5 inches in diameter by 4 inches long can typically yield at least 1000 feet of coronary stent tubing. - The alloying process is particularly advantageous for alloying constituents with large melting temperature differences. In Table IV, the melting temperatures of Ti, Ta, Zr, and Mo are provided.
TABLE IV Melting Temperatures Element Melting Temperature, ° C. Ti 1668 Ta 2996 Zr 1852 Mo 2610 - The melting temperature difference between Ti and Zr, and Ta and Mo is over 500° C. The difference between Ti and Zr is over 150° C. In the method of
FIGS. 4A et seq., aliquots of constituents of the alloy are intimately contacted, mechanically and/or diffusion alloyed and then melted and cast into ingot. By diffusion or mechanical alloying the aliquots, less overall mixing is required in the melting and casting furnace. - In the prealloying step, heating is performed in an inert gas or vacuum, or the outer surfaces of the billet could be coated or canned with a protective metal, such as iron, that could later be chemically dissolved. After drilling and filling or after the diffusion heat treatment, the billet can also be extruded, drawn, or rolled to further consolidate the assembly. The heat treatment or working serves to hold additive material in place within the billet during melting. Also, constituents with high melting points can be essentially encapsulated within, e.g. titanium, minimizing the exposure to any residual air in the casting furnace. For diffusion heating, the assembly can be heated near the melting temperature of the lowest melting temperature constituent and/or the melting temperature of the material of the base rod. For example, for a Ti base rod, the temperature is about 1600° C. or less.
- In embodiments, additives to the base are made in incremental steps in each of multiple melting and ingot casting operations. For example, to alloy Ti 6A1-4V with 43 weight percent tantalum, in the first melting operation the Ti-6A1 -4V bar holes may be filled with 22 weight percent tantalum. After the first ingot is cast, holes are drilled again and filled with another 22 weight percent tantalum and the melting is repeated. Other sequences and magnitudes of Ta adds are made to reach the final alloy with 43 weight percent Ta. This approach is Ta elemental segregation in the ingot if it is added in smaller amounts in multiple melting and ingot casting steps. In addition, homogenization heat treatments between melts can reduce the amount of elemental diffusion needed. Other difficult to melt alloys can be produced by this method such as Ta-Nb, Nb-Zr, Ti-Nb, and Fe-Pt alloy systems. In other embodiments, the additive can be provided in the form of powder or chips rather than a solid wire or rod. The alloying that occurs in the melting and ingot casting process can be further improved by performing a homogenization (elemental diffusion) heat treatment to the ingots between melting operations. Mechanical alloying melting, casting, and heat treating operations can be performed at commercial sources such as Pittsburgh Materials Technology Inc. (Pittsburgh, Pa.), Applegate Group (Woodcliff Lake, N.J.) or Albany Research Center (Albany, Ore.).
- The alloy tubing is formed into stent. For example, selected portions can be removed to define bands and struts. The portions can be removed by laser cutting, as described, for example, in U.S. Pat. No. 5,780,807. In certain embodiments, during laser cutting, a liquid carrier, such as a solvent, gas, or an oil, is flowed through the tube. The carrier can prevent drops formed on one portion from re-depositing on another portion, and/or reduce formation of recast material on the tubular member. Other methods of removing portions of tubular member include mechanical machining (e.g., micro-machining), electrical discharge machining (EDM), photoetching (e.g., acid photoetching), and/or chemical etching.
- The stent can further be finished, e.g., electropolished to a smooth finish, according to conventional methods. In some embodiments, about 0.0001 inch of material can be removed from the interior and/or exterior surfaces by chemical milling and/or electropolishing. The stent can be annealed to refine the mechanical and physical properties of the stent.
- In use, the stent can be used, e.g., delivered and expanded, using a catheter. Suitable catheter systems are described in, for example, Wang U.S. Pat. No. 5,195,969, and Hamlin U.S. Pat. No. 5,270,086. Suitable stents and stent delivery are also exemplified by the Express, Radius® or Symbio® systems, available from Boston Scientific Scimed, Maple Grove, Minn.
- The stent can be of any desired shape and size (e.g., coronary stents, aortic stents, peripheral vascular stents, gastrointestinal stents, urology stents, and neurology stents). Depending on the application, the stent can have a diameter of between, for example, 1 mm to 46 mm. In certain embodiments, a coronary stent can have an expanded diameter of from about 2 mm to about 6 mm. In some embodiments, a peripheral stent can have an expanded diameter of from about 5 mm to about 24 mm. In certain embodiments, a gastrointestinal and/or urology stent can have an expanded diameter of from about 6 mm to about 30 mm. In some embodiments, a neurology stent can have an expanded diameter of from about 1 mm to about 12 mm. An abdominal aortic aneurysm (AAA) stent and a thoracic aortic aneurysm (TAA) stent can have a diameter from about 20 mm to about 46 mm. Stent 100 can be balloon-expandable, self-expandable, or a combination of both (e.g., U.S. Pat. No. 5,366,504).
- The stent can also be a part of a stent-graft. In other embodiments, the stent includes and/or be attached to a biocompatible, non-porous or semi-porous polymer matrix made of polytetrafluoroethylene (PTFE), expanded PTFE, polyethylene, urethane, or polypropylene. The endoprosthesis can include a releasable therapeutic agent, drug, or a pharmaceutically active compound, such as described in U.S. Pat. No. 5,674,242, U.S. Ser. No. 09/895,415, filed Jul. 2, 2001 and U.S. Ser. No. 10/232,265, filed Aug. 30, 2002. The therapeutic agents, drugs, or pharmaceutically active compounds can include, for example, anti-thrombogenic agents, antioxidants, anti-inflammatory agents, anesthetic agents, anti-coagulants, and antibiotics.
- The methods and the embodiments described above can be used to form medical devices other than stents and stent-grafts. For example, the methods and/or materials can be used to form filters, such as removable thrombus filters described in Kim et al., U.S. Pat. No. 6,146,404; in intravascular filters such as those described in Daniel et al., U.S. Pat. No. 6,171,327; and in vena cava filters such as those described in Soon et al., U.S. Pat. No. 6,342,062. The methods and/or materials can be used to form guidewires, such as a Meier steerable guidewire. The methods and/or materials can be used to form vaso-occlusive devices, e.g., coils, used to treat intravascular aneurysms, as described, e.g., in Bashiri et al., U.S. Pat. No. 6,468,266, and Wallace et al., U.S. Pat, No. 6,280,457. The methods and/or materials can be used to form wire to make catheter reinforcement braid. The methods and/or materials can also be used in surgical instruments, such as forceps, needles, clamps, and scalpels.
- Further embodiments are provided in the following examples.
- A titanium-tantalum alloy with a mass absorption coefficient of at least 1.96 cm2/g (iron) and as high as 2.86 cm2/g (half of tantalum) is formulated as follows. The atomic mass coefficient for titanium is 1.21 and for tantalum is 5.72.
- The following equation is used to provide desired radiopacity.
[Atomic % Ti×1.21]+[atomic % Ta×5.72]=1.96 to 2.86 cm2/g. solving far x: (x)(1.21)+(1−x)(5.72)=1.96 cm2/g or 2.86 cm2/g x=0.83 (83 atomic percent Ti) or 0.63 (63 atomic percent TI) or conversely 17 atomic percent Ta or 37 atomic percent Ta. - Conversion of atomic percent to weight percent for the 17 Ta-83 Ti alloy is as follows:
-
- In 1023 atoms of Ti-Ta alloy, there are 0.17×1023 atoms of Ta and 0.83×1023 atoms of Ti.
- 0.17×1023 atoms of Ta/6.02×1023 atoms/mole=0.028 moles of Ta
- 0.83×1023 atoms of Ti/6.02×1023 atoms/mole=0.138 moles of Ti
- (0.028 moles Ta)(180.95 grams/mole atomic weight)=5.07 grams of Ta
- (0.138 moles Ti)(47.88 grams/mole atomic weight)=6.61 grams of Ti
- 5.07 grams Ta+6.61 grams Ti=11.68 grams of alloy
- 6.61g Ti/11.68 g=57 weight percent Ti in alloy.
- 5.07g Ta/11.68 g=43 weight percent Ta in alloy.
- An alloy of 83 atomic percent Ti and 17 atomic percent Ta (57 weight percent Ti and 43 weight percent Ta) has a calculated mass absorption coefficient equivalent to iron and a radiopacity similar to 316L stainless steel. An alloy of 63 atomic percent Ti and 37 atomic percent Ta (31 weight percent Ti and 69 weight percent Ta) has a calculated mass absorption coefficient equivalent to one-half of tantalum. The alloy constituents have magnetic susceptibility less than 3.5×10−3 and are soluble in each other. The tantalum-titanium binary phase diagram (ASM Handbook, Volume 3 Alloy Phase Diagrams, ASM International, 1992, p. 2.374) indicates a 43 to 69 weight percent tantalum to be soluble in titanium as a solid solution two-phase (alpha and beta) material at room temperature. The tantalum-titanium binary phase diagram also indicates that the alloys with 43 to 69 percent tantalum concentration have alpha and beta phase microstructures. No brittle phases are evident in the phase diagram.
- A titanium-molybdenum alloy with a mass absorption coefficient of at least 1.96 cm2/g (iron) and as high as 2.86 cm2/g (halfoftantalum) is formulated as follows.
- The following equation is used to determine desired radiopacity.
[Atomic % Ti×1.21]+[atomic % Mo×7.04]=1.96 to 2.86 cm2/g. (x) (1.21)+(1−x)(7.04)=1.96 cm2/g or 2.86 cm2/g x=0.87 (87 atomic percent Ti) or 0.72 (72 atomic percent Ti) or conversely 13 atomic percent Mo or 28 atomic percent Mo. - Conversion of atomic percent to weight percent for the 13 Mo-87 Ti alloy:
-
- In 1023 atoms of Ti-Mo alloy, there are 0.13×1023 atoms of Mo and 0.87×1023 atoms of Ti.
- 0.13×1023 atoms of Mo/6.02×1023 atoms/mole=0.022 moles of Mo
- 0.87×1023 atoms of Ti/6.02×1023 atoms/mole=0.145 moles of Ti
- (0.022 moles Mo) (95.94 grams/mole atomic weight)=2.11 grams of Mo
- (0.145 moles Ti) 47.88 grams/mole atomic weight)=6.94 grams of Ti
- 2.11 grams Mo+6.94 grams Ti=9.05 grams of alloy
- 6.94g Ti/9.05 g=77 weight percent Ti in alloy.
- 2.11 g Mo/9.05 g=23 weight percent Mo in alloy.
- An alloy of 87 atomic percent Ti and 13 atomic percent mo (77 weight percent Ti and 23 weight percent Mo) has a calculated mass absorption coefficient equivalent to iron and a radiopacity similar to 316L stainless steel. An alloy of 72 atomic percent Ti and 28 atomic percent Mo (56 weight percent Ti and 44 weight percent Mo) has a calculated mass absorption coefficient equivalent to one-half of tantalum and therefore has half the radiopacity of tantalum. The alloy constituents have magnetic susceptibility less than 3.5×10−3 and that are soluble in each other. The molybdenum titanium binary phase diagram indicates (ASM Handbook, Volume 3 Alloy Phase Diagrams, ASM International, 1992, p.2.296) 23 to 44 weight percent molybdenum to be soluble in titanium as a solid solution single (beta) or two-phase (alpha and beta) material at room temperature. The molybdenum-titanium binary phase diagram also indicates that alloys with 23 to 44 percent molybdenum concentration will have beta or beta plus alpha phase microstructures which are common in commercialized titanium engineering alloys such as Ti-6A1-4V. Cooling through the temperature range of about 850 to 695° C. can be performed rapidly (e.g., by argon gas, air cool, or liquid quenchant) to avoid precipitation of significant amounts of alpha-prime, alpha-double prime, or omega phases.
- A method for making an alloy of Ti-6A1-4V ELI with 43 weight percent Ta follows.
- Procure a 3″ diameter round bar of Ti-6A1-4V ELI (such as form Titanium Industries, Inc. in Morristown, N.J.) and cut to 5.5 inches long. Procure 0.5″ diameter tantalum rod (such as from Rembar, Dobbs Ferry, N.Y.) and cut into lengths of 3.25″. Drill eight holes into the titanium bar that are 0.55/0.6″ diameter and 4.5″ deep. Put the eight 3.25″ long pieces of 0.5″ diameter tantalum rod into the holes. Heat the assembly in a vacuum furnace at 1400° C. for 8 hours and vacuum cool. Gas tungsten arc weld (GTAW or TIG) the assembly with the hole-end up to the vacuum arc remelt (VAR) electrode holder. Vacuum arc remelt the assembly and cast an ingot. Heat the ingot in a vacuum furnace at 1400° C. for 8 hours and vacuum cool. Repeat the VAR and heat treatment once ore or multiple times. Machine the ingot into a 2.5″ diameter×4″ long billet. Convert billet to annealed seamless tent tubing.
- Arc melted Ti-Ta alloy button ingots were prepared. Two ingots were melted from a 50-50 mixture (by weight) of Ti-6A1-4V and tantalum rods. One ingot was melted from a 50-50 mixture (by weight) of pure titanium and tantalum rods. Cold rolling and annealing of the ingots were used to form strips for mechanical and physical property testing.
- The ingots were prepared from the following rods and charge materials procured from Goodfellow Corporation, Berwyn, Pa.
TABLE V Rods Material Traceability Ti—6Al—4V Goodfellow LS251817JV; TI017910/1, 5 mm dia × rods 200 mm long rods, 10 pcs, 174 g, annealed Ta rods Goodfellow LS251817JV, TA007920/8, 99.9% pure, 2 mm dia × 200 mm long rods, 5 pcs, 53.2 g, annealed Ti rods Goodfellow LS251817JV, TI007910/12, 2 mm dia × 100 mm long rods, 20 pcs, 28.5 g, 99.6% pure, annealed -
TABLE VI Arc Melter Charge Materials Ti—6Al—4V, # of Ingot mass, Ingot # grams Ti, g Ta, g melt cycles g 2&3 26.0 25.8 3 51.7 1 27.6 26.5 3 53.9 - The rods were cut into lengths of 1-2″, cleaned in acetone, and weighed on a digital scale. The rods were divided up by weight into two groups for melting. The raw materials were melted in an arc melter (Model MRF ABJ-900, Materials Research Furnaces, Inc., Suncook, N.H.). The arc melter was operated at 350-400 amps. Three melt cycles were performed for each alloy.
- Referring to
FIG. 5 , a photomacrograph shows the three ingots after arc melting. The ingot on the left is the Ti-50Ta alloy. The other two ingots are the 50 (Ti-6A1-4V)-50Ta alloy. After melting, each ingot was struck ten times with a hammer to see if it would crack or fracture. All three of the ingots withstood the hammer test without cracking or fracturing and the ingot deformed when hit. This test was performed as an assessment of the formability of the material. Cracking can indicate that the alloy is too brittle for cold rolling. - Three 0.20-0.25″ thick bars were used as a starting stock for cold rolling. The machined dimensions of the rolling blanks are listed in the following table.
TABLE VII Dimensions of Rolling Blanks Bar # Length, inches Width, inches Thickness, inches 1 (Ti—Ta) 3.06 0.57 0.23 2 (Ti64—Ta) 2.17 0.57 0.23 3 (Ti64—Ta) 1.12. 0.49 0.24 - The machined bars were cold rolled to a total reduction in thickness of 50%. The dimensions after cold rolling are listed in the following table.
TABLE VIII Dimensions after 1st Cold Rolling Bar # Length, inches Thickness, inches 1 (Ti—Ta) 4.7 0.10 2 (Ti64—Ta) 3.2 0.10 3 (Ti64—Ta) 1.7 0.10 - The cold rolled strips were annealed in the a vacuum heat treat furnace at 1200° C. for 60 minutes in vacuum followed by a vacuum cool. The purpose of this heat treatment was to continue to homogenize the alloy, recrystallize the cold worked microstructure, and soften the material to allow for further cold rolling. Referring to
FIG. 6 , fine fissures were observed on the surface of the strips. Strip #3 had small edge cracks along the length. None of these flaws were judged to be severe enough to impair further cold rolling. - The three strips were cold rolled to a total reduction in thickness of −50%. The dimensions of the rolled strips are listed in Table IX.
TABLE IX Dimension of Strips After Second Cold Rolling Bar # Length, inches Width, inches Thickness, inches 1 (Ti—Ta) 7.75 0.75 0.058 2 (Ti64—Ta) 4.87 0.81 0.058 3 (Ti64—Ta) 3.00 0.62 0.058 - Referring to
FIG. 7 , the surface and edges of the strips were examined without magnification. Strip #1 had fine edge cracks. Strip #2 had no cracks. Strip #3 had edge cracks. - The cold rolled strips were annealed in the vacuum heat treat furnace at 1000° C. for 30 minutes in vacuum followed by a vacuum cool. The purpose of this heat treatment was to recrystallize the cold worked microstructure and soften the material to allow further cold rolling. The strips were cold rolled to 0.025″ thickness. The dimensions are given in Table X.
TABLE X Dimension of Strips After Third Cold Rolling Campaign Bar # Length, inches Width, inches Thickness, inches 1 (Ti—Ta) 9 and 8 079 0.025 2 (Ti64—Ta) 10 0.88 0.025 3 (Ti64—Ta) 6 0.65 0.025 - Referring to
FIG. 8 , Strips #1 and #3 had many small edge cracks. Strip #2 did not have edge cracks. - The strips were beta solution treated in a vacuum heat treat furnace at 850° C. for 30 minutes and cooled in vacuum. The strips were submitted for metallography. The strips were subjected to tensile specimen machining and testing (Metcut Research Associates, Inc. (Cincinnati, Ohio)). The tensile results were 85-115 ksi UTS, 65-105 YS, and 5-25% elongation.
- Ti-6A1-4V, pure titanium, and tantalum materials had been melted in powder metal form. Sometimes the ingots did not have sufficient formability to allow cold rolling to a final reduction in thickness of 50%. The large surface area of fine powder metal may allow for significant contamination to be carried into the ingot thereby reducing the ductility of the alloy. In this experiment, solid rods were used instead of powder metal for the furnace charges. The smaller surface area of the rods (relative to the powder) should result in better ingot ductility.
- All publications, applications, references, patents referred to in this application are herein incorporated by reference in their entirety.
- Other embodiments are within the claims.
Claims (40)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/672,891 US20050070990A1 (en) | 2003-09-26 | 2003-09-26 | Medical devices and methods of making same |
EP04784496A EP1663071B1 (en) | 2003-09-26 | 2004-09-20 | Balloon-expendable stent and methods of making same |
JP2006528084A JP4921170B2 (en) | 2003-09-26 | 2004-09-20 | Balloon expandable stent, method for manufacturing the same, and article having the stent |
CA002539491A CA2539491A1 (en) | 2003-09-26 | 2004-09-20 | Balloon-expandable stent and methods of making same |
AT04784496T ATE531340T1 (en) | 2003-09-26 | 2004-09-20 | BALLOON EXPANDABLE STENT AND PRODUCTION METHOD THEREOF |
ES04784496T ES2375961T3 (en) | 2003-09-26 | 2004-09-20 | ENDOLUMINAL NULL WITH EXPANDABLE BALL AND METHODS TO DO THE SAME. |
PCT/US2004/030645 WO2005030095A2 (en) | 2003-09-26 | 2004-09-20 | Balloon-expandable stent and methods of making same |
US12/643,629 US8137614B2 (en) | 2003-09-26 | 2009-12-21 | Medical devices and method for making the same |
US13/396,085 US20120150276A1 (en) | 2003-09-26 | 2012-02-14 | Medical devices and method for making the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/672,891 US20050070990A1 (en) | 2003-09-26 | 2003-09-26 | Medical devices and methods of making same |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/643,629 Continuation US8137614B2 (en) | 2003-09-26 | 2009-12-21 | Medical devices and method for making the same |
Publications (1)
Publication Number | Publication Date |
---|---|
US20050070990A1 true US20050070990A1 (en) | 2005-03-31 |
Family
ID=34376494
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/672,891 Abandoned US20050070990A1 (en) | 2003-09-26 | 2003-09-26 | Medical devices and methods of making same |
US12/643,629 Expired - Lifetime US8137614B2 (en) | 2003-09-26 | 2009-12-21 | Medical devices and method for making the same |
US13/396,085 Abandoned US20120150276A1 (en) | 2003-09-26 | 2012-02-14 | Medical devices and method for making the same |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/643,629 Expired - Lifetime US8137614B2 (en) | 2003-09-26 | 2009-12-21 | Medical devices and method for making the same |
US13/396,085 Abandoned US20120150276A1 (en) | 2003-09-26 | 2012-02-14 | Medical devices and method for making the same |
Country Status (7)
Country | Link |
---|---|
US (3) | US20050070990A1 (en) |
EP (1) | EP1663071B1 (en) |
JP (1) | JP4921170B2 (en) |
AT (1) | ATE531340T1 (en) |
CA (1) | CA2539491A1 (en) |
ES (1) | ES2375961T3 (en) |
WO (1) | WO2005030095A2 (en) |
Cited By (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050278929A1 (en) * | 2004-06-16 | 2005-12-22 | National Taipei University Technology | Process of manufacturing stent with therapeutic function in the human body |
US20060097242A1 (en) * | 2004-11-10 | 2006-05-11 | Mitsubishi Denki Kabushiki Kaisha | Semiconductor light-emitting device |
US20060122694A1 (en) * | 2004-12-03 | 2006-06-08 | Stinson Jonathan S | Medical devices and methods of making the same |
US20060222844A1 (en) * | 2005-04-04 | 2006-10-05 | Stinson Jonathan S | Medical devices including composites |
US20060251794A1 (en) * | 2005-05-05 | 2006-11-09 | Torsten Scheuermann | Medical devices and methods of making the same |
US20060259126A1 (en) * | 2005-05-05 | 2006-11-16 | Jason Lenz | Medical devices and methods of making the same |
US20060276875A1 (en) * | 2005-05-27 | 2006-12-07 | Stinson Jonathan S | Medical devices |
US20070009564A1 (en) * | 2005-06-22 | 2007-01-11 | Mcclain James B | Drug/polymer composite materials and methods of making the same |
US20070032862A1 (en) * | 2005-08-08 | 2007-02-08 | Jan Weber | Medical devices |
US20070131318A1 (en) * | 2005-12-12 | 2007-06-14 | Accellent, Inc. | Medical alloys with a non-alloyed dispersion and methods of making same |
US20070239256A1 (en) * | 2006-03-22 | 2007-10-11 | Jan Weber | Medical devices having electrical circuits with multilayer regions |
US20080071352A1 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
US20080071355A1 (en) * | 2006-09-14 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical Devices with Drug-Eluting Coating |
US20080069858A1 (en) * | 2006-09-20 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical devices having biodegradable polymeric regions with overlying hard, thin layers |
US20080071344A1 (en) * | 2006-09-18 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical device with porous surface |
US20080071351A1 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Scimed, Inc. | Endoprosthesis with adjustable surface features |
US20080095919A1 (en) * | 2006-10-23 | 2008-04-24 | Mcclain James B | Holder For Electrically Charging A Substrate During Coating |
US20080097577A1 (en) * | 2006-10-20 | 2008-04-24 | Boston Scientific Scimed, Inc. | Medical device hydrogen surface treatment by electrochemical reduction |
US20080132998A1 (en) * | 2004-09-29 | 2008-06-05 | Alveolus, Inc. | Active stent |
US20080131479A1 (en) * | 2006-08-02 | 2008-06-05 | Jan Weber | Endoprosthesis with three-dimensional disintegration control |
US20080147177A1 (en) * | 2006-11-09 | 2008-06-19 | Torsten Scheuermann | Endoprosthesis with coatings |
US20080161900A1 (en) * | 2006-06-20 | 2008-07-03 | Boston Scientific Scimed, Inc. | Medical devices including composites |
US20080160259A1 (en) * | 2006-12-28 | 2008-07-03 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US20080195194A1 (en) * | 2007-02-13 | 2008-08-14 | Abbott Cardiovascular Systems Inc. | Mri compatible, radiopaque alloys for use in medical devices |
US20090024199A1 (en) * | 2007-07-16 | 2009-01-22 | Medtronic Vascular, Inc. | Controlled Porosity Stent |
US20090118814A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090118821A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
US20090149942A1 (en) * | 2007-07-19 | 2009-06-11 | Boston Scientific Scimed, Inc. | Endoprosthesis having a non-fouling surface |
US20090186069A1 (en) * | 2006-04-26 | 2009-07-23 | Micell Technologies, Inc. | Coatings Containing Multiple Drugs |
US20090285714A1 (en) * | 2008-05-19 | 2009-11-19 | Pulse Technologies, Inc. | Implantable medical Devices Composed of a Radiopaque Alloy and Method of Making the Alloy |
US20090292351A1 (en) * | 2008-04-17 | 2009-11-26 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
US20090299468A1 (en) * | 2008-05-29 | 2009-12-03 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090319032A1 (en) * | 2008-06-18 | 2009-12-24 | Boston Scientific Scimed, Inc | Endoprosthesis coating |
US20100010620A1 (en) * | 2008-07-09 | 2010-01-14 | Boston Scientific Scimed, Inc. | Stent |
US20100015200A1 (en) * | 2008-07-17 | 2010-01-21 | Micell Technologies, Inc. | Drug Delivery Medical Device |
US20100057188A1 (en) * | 2008-08-28 | 2010-03-04 | Boston Scientific Scimed, Inc. | Endoprostheses with porous regions and non-polymeric coating |
US20100063580A1 (en) * | 2007-01-08 | 2010-03-11 | Mcclain James B | Stents having biodegradable layers |
US20100063584A1 (en) * | 2008-09-05 | 2010-03-11 | Boston Scientific Scimed, Inc. | Endoprostheses |
US20100211164A1 (en) * | 2007-04-17 | 2010-08-19 | Mcclain James B | Stents having biodegradable layers |
US7780798B2 (en) | 2006-10-13 | 2010-08-24 | Boston Scientific Scimed, Inc. | Medical devices including hardened alloys |
US20100241220A1 (en) * | 2009-03-23 | 2010-09-23 | Mcclain James B | Peripheral Stents Having Layers |
US20100239635A1 (en) * | 2009-03-23 | 2010-09-23 | Micell Technologies, Inc. | Drug delivery medical device |
US20100256718A1 (en) * | 2009-04-06 | 2010-10-07 | Medtronic, Inc. | Wire Configuration and Method of Making for an Implantable Medical Apparatus |
US20100256748A1 (en) * | 2009-04-01 | 2010-10-07 | Micell Technologies, Inc. | Coated stents |
US20100272778A1 (en) * | 2007-04-17 | 2010-10-28 | Micell Technologies, Inc. | Stents having controlled elution |
US20100298928A1 (en) * | 2007-10-19 | 2010-11-25 | Micell Technologies, Inc. | Drug Coated Stents |
US20110022162A1 (en) * | 2009-07-23 | 2011-01-27 | Boston Scientific Scimed, Inc. | Endoprostheses |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20110159069A1 (en) * | 2008-12-26 | 2011-06-30 | Shaw Wendy J | Medical Implants and Methods of Making Medical Implants |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US20110190864A1 (en) * | 2010-02-02 | 2011-08-04 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8002821B2 (en) | 2006-09-18 | 2011-08-23 | Boston Scientific Scimed, Inc. | Bioerodible metallic ENDOPROSTHESES |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20110238149A1 (en) * | 2010-03-26 | 2011-09-29 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US20110238161A1 (en) * | 2010-03-26 | 2011-09-29 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US20110238153A1 (en) * | 2010-03-26 | 2011-09-29 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US8052744B2 (en) | 2006-09-15 | 2011-11-08 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US8057534B2 (en) | 2006-09-15 | 2011-11-15 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8066763B2 (en) | 1998-04-11 | 2011-11-29 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
US8080055B2 (en) | 2006-12-28 | 2011-12-20 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
US8221822B2 (en) | 2007-07-31 | 2012-07-17 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US8267992B2 (en) | 2009-03-02 | 2012-09-18 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
WO2012142319A1 (en) | 2011-04-13 | 2012-10-18 | Micell Technologies, Inc. | Stents having controlled elution |
US8303643B2 (en) | 2001-06-27 | 2012-11-06 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
US8340759B2 (en) | 2011-04-22 | 2012-12-25 | Medtronic, Inc. | Large-pitch coil configurations for a medical device |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
US8574615B2 (en) | 2006-03-24 | 2013-11-05 | Boston Scientific Scimed, Inc. | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US8660662B2 (en) | 2011-04-22 | 2014-02-25 | Medtronic, Inc. | Low impedance, low modulus wire configurations for a medical device |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US8758429B2 (en) | 2005-07-15 | 2014-06-24 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US8771343B2 (en) | 2006-06-29 | 2014-07-08 | Boston Scientific Scimed, Inc. | Medical devices with selective titanium oxide coatings |
US8808726B2 (en) | 2006-09-15 | 2014-08-19 | Boston Scientific Scimed. Inc. | Bioerodible endoprostheses and methods of making the same |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
US8834560B2 (en) | 2010-04-06 | 2014-09-16 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8900651B2 (en) | 2007-05-25 | 2014-12-02 | Micell Technologies, Inc. | Polymer films for medical device coating |
US8900292B2 (en) | 2007-08-03 | 2014-12-02 | Boston Scientific Scimed, Inc. | Coating for medical device having increased surface area |
US8920490B2 (en) | 2010-05-13 | 2014-12-30 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8920491B2 (en) | 2008-04-22 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
US8932346B2 (en) | 2008-04-24 | 2015-01-13 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
US20150182324A1 (en) * | 2005-06-10 | 2015-07-02 | Keystone Heart Ltd. | Implant device particularly useful for implantation in the intravascular system for diverting emboli |
US9409008B2 (en) | 2011-04-22 | 2016-08-09 | Medtronic, Inc. | Cable configurations for a medical device |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
US9668849B2 (en) | 2001-12-05 | 2017-06-06 | Keystone Heart Ltd. | Endovascular device for entrapment of participate matter and method for use |
US9987130B2 (en) | 2011-12-13 | 2018-06-05 | Boston Scientific Scimed, Inc. | Decalcifying heart valve |
US20180258512A1 (en) * | 2015-09-17 | 2018-09-13 | Nanyang Technological University | Titanium-tantalum alloy and method of forming thereof |
US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
US10232092B2 (en) | 2010-04-22 | 2019-03-19 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
US10272606B2 (en) | 2013-05-15 | 2019-04-30 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US10464100B2 (en) | 2011-05-31 | 2019-11-05 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
US10835396B2 (en) | 2005-07-15 | 2020-11-17 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
US11039943B2 (en) | 2013-03-12 | 2021-06-22 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
US11904118B2 (en) | 2010-07-16 | 2024-02-20 | Micell Medtech Inc. | Drug delivery medical device |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008036076A (en) * | 2006-08-04 | 2008-02-21 | Japan Health Science Foundation | Balloon-expandable stent and its production method |
DE102007031796A1 (en) * | 2007-07-07 | 2009-01-08 | WRW Consulting GbR (Vertretungsberechtigter Gesellschafter: Dr. Walter Reith, 66424 Homburg) | Radially expandable system for use in body tubes |
US20110303553A1 (en) * | 2010-06-11 | 2011-12-15 | Inman Maria E | Electrochemical system and method for machining strongly passivating metals |
WO2012094604A2 (en) * | 2011-01-06 | 2012-07-12 | Purdue Research Foundation | Large strain extrusion machining processes and bulk forms produced therefrom |
JP2013181190A (en) | 2012-02-29 | 2013-09-12 | Seiko Instruments Inc | Co-BASED ALLOY FOR LIVING BODY AND STENT |
US9006147B2 (en) * | 2012-07-11 | 2015-04-14 | Faraday Technology, Inc. | Electrochemical system and method for electropolishing superconductive radio frequency cavities |
Citations (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3161503A (en) * | 1961-09-27 | 1964-12-15 | Titanium Metals Corp | Corrosion resistant alloy |
US4040129A (en) * | 1970-07-15 | 1977-08-09 | Institut Dr. Ing. Reinhard Straumann Ag | Surgical implant and alloy for use in making an implant |
US5047030A (en) * | 1987-02-20 | 1991-09-10 | Klaus Draenert | Suction drainage-bone screw |
US5169597A (en) * | 1989-12-21 | 1992-12-08 | Davidson James A | Biocompatible low modulus titanium alloy for medical implants |
US5195969A (en) * | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5270086A (en) * | 1989-09-25 | 1993-12-14 | Schneider (Usa) Inc. | Multilayer extrusion of angioplasty balloons |
US5366504A (en) * | 1992-05-20 | 1994-11-22 | Boston Scientific Corporation | Tubular medical prosthesis |
US5383928A (en) * | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
US5545227A (en) * | 1989-12-21 | 1996-08-13 | Smith & Nephew Richards, Inc. | Biocompatible low modulus medical implants |
US5643312A (en) * | 1994-02-25 | 1997-07-01 | Fischell Robert | Stent having a multiplicity of closed circular structures |
US5653727A (en) * | 1987-10-19 | 1997-08-05 | Medtronic, Inc. | Intravascular stent |
US5685306A (en) * | 1989-12-21 | 1997-11-11 | Smith & Nephew, Inc. | Flexible, biocompatible, metal alloy catheter |
US5728158A (en) * | 1991-10-28 | 1998-03-17 | Advanced Cardiovascular Systems, Inc. | Expandable stents |
US5780807A (en) * | 1994-11-28 | 1998-07-14 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for direct laser cutting of metal stents |
US5888201A (en) * | 1996-02-08 | 1999-03-30 | Schneider (Usa) Inc | Titanium alloy self-expanding stent |
US5954724A (en) * | 1997-03-27 | 1999-09-21 | Davidson; James A. | Titanium molybdenum hafnium alloys for medical implants and devices |
US5972027A (en) * | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
US6027528A (en) * | 1996-05-28 | 2000-02-22 | Cordis Corporation | Composite material endoprosthesis |
US6146404A (en) * | 1999-09-03 | 2000-11-14 | Scimed Life Systems, Inc. | Removable thrombus filter |
US6171327B1 (en) * | 1999-02-24 | 2001-01-09 | Scimed Life Systems, Inc. | Intravascular filter and method |
US6258182B1 (en) * | 1998-03-05 | 2001-07-10 | Memry Corporation | Pseudoelastic β titanium alloy and uses therefor |
US6280457B1 (en) * | 1999-06-04 | 2001-08-28 | Scimed Life Systems, Inc. | Polymer covered vaso-occlusive devices and methods of producing such devices |
US6342062B1 (en) * | 1998-09-24 | 2002-01-29 | Scimed Life Systems, Inc. | Retrieval devices for vena cava filter |
US6375458B1 (en) * | 1999-05-17 | 2002-04-23 | Memry Corporation | Medical instruments and devices and parts thereof using shape memory alloys |
US6409852B1 (en) * | 1999-01-07 | 2002-06-25 | Jiin-Huey Chern | Biocompatible low modulus titanium alloy for medical implant |
US6468266B1 (en) * | 1997-08-29 | 2002-10-22 | Scimed Life Systems, Inc. | Fast detaching electrically isolated implant |
US20030003220A1 (en) * | 2001-07-02 | 2003-01-02 | Sheng-Ping Zhong | Coating a medical appliance with a bubble jet printing head |
US20030185895A1 (en) * | 2002-03-29 | 2003-10-02 | Janel Lanphere | Drug delivery particle |
US20040143317A1 (en) * | 2003-01-17 | 2004-07-22 | Stinson Jonathan S. | Medical devices |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3549429A (en) * | 1968-08-27 | 1970-12-22 | Surface Technology Corp | Wear and abrasion resistant materials |
US4857269A (en) * | 1988-09-09 | 1989-08-15 | Pfizer Hospital Products Group Inc. | High strength, low modulus, ductile, biopcompatible titanium alloy |
US4994071A (en) * | 1989-05-22 | 1991-02-19 | Cordis Corporation | Bifurcating stent apparatus and method |
US5232361A (en) * | 1992-04-06 | 1993-08-03 | Sachdeva Rohit C L | Orthodontic bracket |
US5843168A (en) * | 1997-03-31 | 1998-12-01 | Medtronic, Inc. | Double wave stent with strut |
GB9806085D0 (en) * | 1998-03-23 | 1998-05-20 | Xerox Corp | Text summarisation using light syntactic parsing |
NL1011779C2 (en) * | 1999-04-13 | 2000-10-16 | Elephant Dental Bv | Biomedical device or implant. |
US6767418B1 (en) * | 1999-04-23 | 2004-07-27 | Terumo Kabushiki Kaisha | Ti-Zr type alloy and medical appliance formed thereof |
US6402859B1 (en) * | 1999-09-10 | 2002-06-11 | Terumo Corporation | β-titanium alloy wire, method for its production and medical instruments made by said β-titanium alloy wire |
US20030018380A1 (en) * | 2000-07-07 | 2003-01-23 | Craig Charles H. | Platinum enhanced alloy and intravascular or implantable medical devices manufactured therefrom |
-
2003
- 2003-09-26 US US10/672,891 patent/US20050070990A1/en not_active Abandoned
-
2004
- 2004-09-20 CA CA002539491A patent/CA2539491A1/en not_active Abandoned
- 2004-09-20 EP EP04784496A patent/EP1663071B1/en not_active Not-in-force
- 2004-09-20 JP JP2006528084A patent/JP4921170B2/en not_active Expired - Fee Related
- 2004-09-20 ES ES04784496T patent/ES2375961T3/en active Active
- 2004-09-20 AT AT04784496T patent/ATE531340T1/en active
- 2004-09-20 WO PCT/US2004/030645 patent/WO2005030095A2/en active Application Filing
-
2009
- 2009-12-21 US US12/643,629 patent/US8137614B2/en not_active Expired - Lifetime
-
2012
- 2012-02-14 US US13/396,085 patent/US20120150276A1/en not_active Abandoned
Patent Citations (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3161503A (en) * | 1961-09-27 | 1964-12-15 | Titanium Metals Corp | Corrosion resistant alloy |
US4040129A (en) * | 1970-07-15 | 1977-08-09 | Institut Dr. Ing. Reinhard Straumann Ag | Surgical implant and alloy for use in making an implant |
US5047030A (en) * | 1987-02-20 | 1991-09-10 | Klaus Draenert | Suction drainage-bone screw |
US5653727A (en) * | 1987-10-19 | 1997-08-05 | Medtronic, Inc. | Intravascular stent |
US5270086A (en) * | 1989-09-25 | 1993-12-14 | Schneider (Usa) Inc. | Multilayer extrusion of angioplasty balloons |
US5685306A (en) * | 1989-12-21 | 1997-11-11 | Smith & Nephew, Inc. | Flexible, biocompatible, metal alloy catheter |
US5169597A (en) * | 1989-12-21 | 1992-12-08 | Davidson James A | Biocompatible low modulus titanium alloy for medical implants |
US5545227A (en) * | 1989-12-21 | 1996-08-13 | Smith & Nephew Richards, Inc. | Biocompatible low modulus medical implants |
US5690670A (en) * | 1989-12-21 | 1997-11-25 | Davidson; James A. | Stents of enhanced biocompatibility and hemocompatibility |
US5195969A (en) * | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5728158A (en) * | 1991-10-28 | 1998-03-17 | Advanced Cardiovascular Systems, Inc. | Expandable stents |
US5366504A (en) * | 1992-05-20 | 1994-11-22 | Boston Scientific Corporation | Tubular medical prosthesis |
US5383928A (en) * | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
US5643312A (en) * | 1994-02-25 | 1997-07-01 | Fischell Robert | Stent having a multiplicity of closed circular structures |
US5780807A (en) * | 1994-11-28 | 1998-07-14 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for direct laser cutting of metal stents |
US5888201A (en) * | 1996-02-08 | 1999-03-30 | Schneider (Usa) Inc | Titanium alloy self-expanding stent |
US6027528A (en) * | 1996-05-28 | 2000-02-22 | Cordis Corporation | Composite material endoprosthesis |
US5954724A (en) * | 1997-03-27 | 1999-09-21 | Davidson; James A. | Titanium molybdenum hafnium alloys for medical implants and devices |
US6200685B1 (en) * | 1997-03-27 | 2001-03-13 | James A. Davidson | Titanium molybdenum hafnium alloy |
US6468266B1 (en) * | 1997-08-29 | 2002-10-22 | Scimed Life Systems, Inc. | Fast detaching electrically isolated implant |
US5972027A (en) * | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
US6258182B1 (en) * | 1998-03-05 | 2001-07-10 | Memry Corporation | Pseudoelastic β titanium alloy and uses therefor |
US6342062B1 (en) * | 1998-09-24 | 2002-01-29 | Scimed Life Systems, Inc. | Retrieval devices for vena cava filter |
US6409852B1 (en) * | 1999-01-07 | 2002-06-25 | Jiin-Huey Chern | Biocompatible low modulus titanium alloy for medical implant |
US6171327B1 (en) * | 1999-02-24 | 2001-01-09 | Scimed Life Systems, Inc. | Intravascular filter and method |
US6375458B1 (en) * | 1999-05-17 | 2002-04-23 | Memry Corporation | Medical instruments and devices and parts thereof using shape memory alloys |
US6280457B1 (en) * | 1999-06-04 | 2001-08-28 | Scimed Life Systems, Inc. | Polymer covered vaso-occlusive devices and methods of producing such devices |
US6146404A (en) * | 1999-09-03 | 2000-11-14 | Scimed Life Systems, Inc. | Removable thrombus filter |
US20030003220A1 (en) * | 2001-07-02 | 2003-01-02 | Sheng-Ping Zhong | Coating a medical appliance with a bubble jet printing head |
US20030185895A1 (en) * | 2002-03-29 | 2003-10-02 | Janel Lanphere | Drug delivery particle |
US20040143317A1 (en) * | 2003-01-17 | 2004-07-22 | Stinson Jonathan S. | Medical devices |
Cited By (166)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8066763B2 (en) | 1998-04-11 | 2011-11-29 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US8303643B2 (en) | 2001-06-27 | 2012-11-06 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
US9668849B2 (en) | 2001-12-05 | 2017-06-06 | Keystone Heart Ltd. | Endovascular device for entrapment of participate matter and method for use |
US10624732B2 (en) | 2001-12-05 | 2020-04-21 | Keystone Heart Ltd. | Endovascular device for entrapment of participate matter and method for use |
US20050278929A1 (en) * | 2004-06-16 | 2005-12-22 | National Taipei University Technology | Process of manufacturing stent with therapeutic function in the human body |
US7887579B2 (en) * | 2004-09-29 | 2011-02-15 | Merit Medical Systems, Inc. | Active stent |
US20080132998A1 (en) * | 2004-09-29 | 2008-06-05 | Alveolus, Inc. | Active stent |
US20060097242A1 (en) * | 2004-11-10 | 2006-05-11 | Mitsubishi Denki Kabushiki Kaisha | Semiconductor light-emitting device |
US20060122694A1 (en) * | 2004-12-03 | 2006-06-08 | Stinson Jonathan S | Medical devices and methods of making the same |
US20060222844A1 (en) * | 2005-04-04 | 2006-10-05 | Stinson Jonathan S | Medical devices including composites |
US7641983B2 (en) | 2005-04-04 | 2010-01-05 | Boston Scientific Scimed, Inc. | Medical devices including composites |
US20060259126A1 (en) * | 2005-05-05 | 2006-11-16 | Jason Lenz | Medical devices and methods of making the same |
US20060251794A1 (en) * | 2005-05-05 | 2006-11-09 | Torsten Scheuermann | Medical devices and methods of making the same |
US8071155B2 (en) | 2005-05-05 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US20090214373A1 (en) * | 2005-05-27 | 2009-08-27 | Boston Scientific Scimed, Inc. | Medical Devices |
US20060276875A1 (en) * | 2005-05-27 | 2006-12-07 | Stinson Jonathan S | Medical devices |
US20150182324A1 (en) * | 2005-06-10 | 2015-07-02 | Keystone Heart Ltd. | Implant device particularly useful for implantation in the intravascular system for diverting emboli |
US20070009564A1 (en) * | 2005-06-22 | 2007-01-11 | Mcclain James B | Drug/polymer composite materials and methods of making the same |
US10835396B2 (en) | 2005-07-15 | 2020-11-17 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
US8758429B2 (en) | 2005-07-15 | 2014-06-24 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US9827117B2 (en) | 2005-07-15 | 2017-11-28 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US11911301B2 (en) | 2005-07-15 | 2024-02-27 | Micell Medtech Inc. | Polymer coatings containing drug powder of controlled morphology |
US10898353B2 (en) | 2005-07-15 | 2021-01-26 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US20070032862A1 (en) * | 2005-08-08 | 2007-02-08 | Jan Weber | Medical devices |
US20070032861A1 (en) * | 2005-08-08 | 2007-02-08 | Boston Scientific Scimed, Inc. | MRI resonator system with stent implant |
US7778684B2 (en) | 2005-08-08 | 2010-08-17 | Boston Scientific Scimed, Inc. | MRI resonator system with stent implant |
US20070131318A1 (en) * | 2005-12-12 | 2007-06-14 | Accellent, Inc. | Medical alloys with a non-alloyed dispersion and methods of making same |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US20070239256A1 (en) * | 2006-03-22 | 2007-10-11 | Jan Weber | Medical devices having electrical circuits with multilayer regions |
US8574615B2 (en) | 2006-03-24 | 2013-11-05 | Boston Scientific Scimed, Inc. | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US11850333B2 (en) | 2006-04-26 | 2023-12-26 | Micell Medtech Inc. | Coatings containing multiple drugs |
US9737645B2 (en) | 2006-04-26 | 2017-08-22 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US9415142B2 (en) | 2006-04-26 | 2016-08-16 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US20090186069A1 (en) * | 2006-04-26 | 2009-07-23 | Micell Technologies, Inc. | Coatings Containing Multiple Drugs |
US11007307B2 (en) | 2006-04-26 | 2021-05-18 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US8852625B2 (en) | 2006-04-26 | 2014-10-07 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US9011516B2 (en) | 2006-06-20 | 2015-04-21 | Boston Scientific Scimed, Inc. | Medical devices including composites |
US20080161900A1 (en) * | 2006-06-20 | 2008-07-03 | Boston Scientific Scimed, Inc. | Medical devices including composites |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
US8771343B2 (en) | 2006-06-29 | 2014-07-08 | Boston Scientific Scimed, Inc. | Medical devices with selective titanium oxide coatings |
US8052743B2 (en) | 2006-08-02 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis with three-dimensional disintegration control |
US20080131479A1 (en) * | 2006-08-02 | 2008-06-05 | Jan Weber | Endoprosthesis with three-dimensional disintegration control |
US8353949B2 (en) | 2006-09-14 | 2013-01-15 | Boston Scientific Scimed, Inc. | Medical devices with drug-eluting coating |
US20080071355A1 (en) * | 2006-09-14 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical Devices with Drug-Eluting Coating |
US20080071351A1 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Scimed, Inc. | Endoprosthesis with adjustable surface features |
US7955382B2 (en) | 2006-09-15 | 2011-06-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with adjustable surface features |
US20080071352A1 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
US8052744B2 (en) | 2006-09-15 | 2011-11-08 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US8128689B2 (en) | 2006-09-15 | 2012-03-06 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
US8057534B2 (en) | 2006-09-15 | 2011-11-15 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8808726B2 (en) | 2006-09-15 | 2014-08-19 | Boston Scientific Scimed. Inc. | Bioerodible endoprostheses and methods of making the same |
US20080071344A1 (en) * | 2006-09-18 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical device with porous surface |
US8002821B2 (en) | 2006-09-18 | 2011-08-23 | Boston Scientific Scimed, Inc. | Bioerodible metallic ENDOPROSTHESES |
US20080069858A1 (en) * | 2006-09-20 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical devices having biodegradable polymeric regions with overlying hard, thin layers |
US7780798B2 (en) | 2006-10-13 | 2010-08-24 | Boston Scientific Scimed, Inc. | Medical devices including hardened alloys |
US20080097577A1 (en) * | 2006-10-20 | 2008-04-24 | Boston Scientific Scimed, Inc. | Medical device hydrogen surface treatment by electrochemical reduction |
US20080095919A1 (en) * | 2006-10-23 | 2008-04-24 | Mcclain James B | Holder For Electrically Charging A Substrate During Coating |
US9539593B2 (en) | 2006-10-23 | 2017-01-10 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US20080147177A1 (en) * | 2006-11-09 | 2008-06-19 | Torsten Scheuermann | Endoprosthesis with coatings |
US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
US8080055B2 (en) | 2006-12-28 | 2011-12-20 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US8715339B2 (en) | 2006-12-28 | 2014-05-06 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US20080160259A1 (en) * | 2006-12-28 | 2008-07-03 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US9034456B2 (en) | 2006-12-28 | 2015-05-19 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US20100063580A1 (en) * | 2007-01-08 | 2010-03-11 | Mcclain James B | Stents having biodegradable layers |
US9737642B2 (en) | 2007-01-08 | 2017-08-22 | Micell Technologies, Inc. | Stents having biodegradable layers |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
US10617795B2 (en) | 2007-01-08 | 2020-04-14 | Micell Technologies, Inc. | Stents having biodegradable layers |
US20080195194A1 (en) * | 2007-02-13 | 2008-08-14 | Abbott Cardiovascular Systems Inc. | Mri compatible, radiopaque alloys for use in medical devices |
WO2008100852A3 (en) * | 2007-02-13 | 2009-12-03 | Abbott Cardiovascular Systems Inc. | Mri compatible, radiopaque alloys for use in medical devices |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
US9775729B2 (en) | 2007-04-17 | 2017-10-03 | Micell Technologies, Inc. | Stents having controlled elution |
US20100211164A1 (en) * | 2007-04-17 | 2010-08-19 | Mcclain James B | Stents having biodegradable layers |
US9486338B2 (en) | 2007-04-17 | 2016-11-08 | Micell Technologies, Inc. | Stents having controlled elution |
US20100272778A1 (en) * | 2007-04-17 | 2010-10-28 | Micell Technologies, Inc. | Stents having controlled elution |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
US8900651B2 (en) | 2007-05-25 | 2014-12-02 | Micell Technologies, Inc. | Polymer films for medical device coating |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8790392B2 (en) | 2007-07-11 | 2014-07-29 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20110224783A1 (en) * | 2007-07-11 | 2011-09-15 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8205317B2 (en) * | 2007-07-16 | 2012-06-26 | Medtronic Vascular, Inc. | Method of manufacturing a controlled porosity stent |
US20090024199A1 (en) * | 2007-07-16 | 2009-01-22 | Medtronic Vascular, Inc. | Controlled Porosity Stent |
US9284409B2 (en) | 2007-07-19 | 2016-03-15 | Boston Scientific Scimed, Inc. | Endoprosthesis having a non-fouling surface |
US20090149942A1 (en) * | 2007-07-19 | 2009-06-11 | Boston Scientific Scimed, Inc. | Endoprosthesis having a non-fouling surface |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
US8221822B2 (en) | 2007-07-31 | 2012-07-17 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
US8900292B2 (en) | 2007-08-03 | 2014-12-02 | Boston Scientific Scimed, Inc. | Coating for medical device having increased surface area |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US20100298928A1 (en) * | 2007-10-19 | 2010-11-25 | Micell Technologies, Inc. | Drug Coated Stents |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US20090118821A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
US20090118814A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
US20090292351A1 (en) * | 2008-04-17 | 2009-11-26 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
US10350333B2 (en) | 2008-04-17 | 2019-07-16 | Micell Technologies, Inc. | Stents having bioabsorable layers |
US9789233B2 (en) | 2008-04-17 | 2017-10-17 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
US8920491B2 (en) | 2008-04-22 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
US8932346B2 (en) | 2008-04-24 | 2015-01-13 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
WO2009142780A1 (en) * | 2008-05-19 | 2009-11-26 | Pulse Technolgies, Inc. | Implantable medical devices composed of a radiopaque alloy and method making the alloy |
US20090285714A1 (en) * | 2008-05-19 | 2009-11-19 | Pulse Technologies, Inc. | Implantable medical Devices Composed of a Radiopaque Alloy and Method of Making the Alloy |
US20090299468A1 (en) * | 2008-05-29 | 2009-12-03 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US8449603B2 (en) | 2008-06-18 | 2013-05-28 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090319032A1 (en) * | 2008-06-18 | 2009-12-24 | Boston Scientific Scimed, Inc | Endoprosthesis coating |
US20100010620A1 (en) * | 2008-07-09 | 2010-01-14 | Boston Scientific Scimed, Inc. | Stent |
US9078777B2 (en) | 2008-07-09 | 2015-07-14 | Boston Scientific Scimed, Inc. | Stent with non-round cross-section in an unexpanded state |
US9486431B2 (en) | 2008-07-17 | 2016-11-08 | Micell Technologies, Inc. | Drug delivery medical device |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
US9981071B2 (en) | 2008-07-17 | 2018-05-29 | Micell Technologies, Inc. | Drug delivery medical device |
US20100015200A1 (en) * | 2008-07-17 | 2010-01-21 | Micell Technologies, Inc. | Drug Delivery Medical Device |
US10350391B2 (en) | 2008-07-17 | 2019-07-16 | Micell Technologies, Inc. | Drug delivery medical device |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US20100057188A1 (en) * | 2008-08-28 | 2010-03-04 | Boston Scientific Scimed, Inc. | Endoprostheses with porous regions and non-polymeric coating |
US8114153B2 (en) | 2008-09-05 | 2012-02-14 | Boston Scientific Scimed, Inc. | Endoprostheses |
US20100063584A1 (en) * | 2008-09-05 | 2010-03-11 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
US20110159069A1 (en) * | 2008-12-26 | 2011-06-30 | Shaw Wendy J | Medical Implants and Methods of Making Medical Implants |
US8267992B2 (en) | 2009-03-02 | 2012-09-18 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
US20100241220A1 (en) * | 2009-03-23 | 2010-09-23 | Mcclain James B | Peripheral Stents Having Layers |
US20100239635A1 (en) * | 2009-03-23 | 2010-09-23 | Micell Technologies, Inc. | Drug delivery medical device |
US10653820B2 (en) | 2009-04-01 | 2020-05-19 | Micell Technologies, Inc. | Coated stents |
US9981072B2 (en) | 2009-04-01 | 2018-05-29 | Micell Technologies, Inc. | Coated stents |
US20100256748A1 (en) * | 2009-04-01 | 2010-10-07 | Micell Technologies, Inc. | Coated stents |
US8639352B2 (en) | 2009-04-06 | 2014-01-28 | Medtronic, Inc. | Wire configuration and method of making for an implantable medical apparatus |
US20100256718A1 (en) * | 2009-04-06 | 2010-10-07 | Medtronic, Inc. | Wire Configuration and Method of Making for an Implantable Medical Apparatus |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
US20110022162A1 (en) * | 2009-07-23 | 2011-01-27 | Boston Scientific Scimed, Inc. | Endoprostheses |
US20110190864A1 (en) * | 2010-02-02 | 2011-08-04 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
US11369498B2 (en) | 2010-02-02 | 2022-06-28 | MT Acquisition Holdings LLC | Stent and stent delivery system with improved deliverability |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US9687864B2 (en) | 2010-03-26 | 2017-06-27 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US8895099B2 (en) | 2010-03-26 | 2014-11-25 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US20110238149A1 (en) * | 2010-03-26 | 2011-09-29 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US20110238161A1 (en) * | 2010-03-26 | 2011-09-29 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US20110238153A1 (en) * | 2010-03-26 | 2011-09-29 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8834560B2 (en) | 2010-04-06 | 2014-09-16 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US10232092B2 (en) | 2010-04-22 | 2019-03-19 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
US8920490B2 (en) | 2010-05-13 | 2014-12-30 | Boston Scientific Scimed, Inc. | Endoprostheses |
US11904118B2 (en) | 2010-07-16 | 2024-02-20 | Micell Medtech Inc. | Drug delivery medical device |
WO2012142319A1 (en) | 2011-04-13 | 2012-10-18 | Micell Technologies, Inc. | Stents having controlled elution |
US8660662B2 (en) | 2011-04-22 | 2014-02-25 | Medtronic, Inc. | Low impedance, low modulus wire configurations for a medical device |
US9409008B2 (en) | 2011-04-22 | 2016-08-09 | Medtronic, Inc. | Cable configurations for a medical device |
US8340759B2 (en) | 2011-04-22 | 2012-12-25 | Medtronic, Inc. | Large-pitch coil configurations for a medical device |
US10464100B2 (en) | 2011-05-31 | 2019-11-05 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
US10729819B2 (en) | 2011-07-15 | 2020-08-04 | Micell Technologies, Inc. | Drug delivery medical device |
US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
US11357623B2 (en) | 2011-12-13 | 2022-06-14 | Boston Scientific Scimed, Inc. | Decalcifying heart valve |
US9987130B2 (en) | 2011-12-13 | 2018-06-05 | Boston Scientific Scimed, Inc. | Decalcifying heart valve |
US11039943B2 (en) | 2013-03-12 | 2021-06-22 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US10272606B2 (en) | 2013-05-15 | 2019-04-30 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US20180258512A1 (en) * | 2015-09-17 | 2018-09-13 | Nanyang Technological University | Titanium-tantalum alloy and method of forming thereof |
Also Published As
Publication number | Publication date |
---|---|
EP1663071A2 (en) | 2006-06-07 |
ATE531340T1 (en) | 2011-11-15 |
US20100228334A1 (en) | 2010-09-09 |
EP1663071B1 (en) | 2011-11-02 |
WO2005030095A3 (en) | 2005-07-14 |
CA2539491A1 (en) | 2005-04-07 |
JP4921170B2 (en) | 2012-04-25 |
US20120150276A1 (en) | 2012-06-14 |
JP2007517536A (en) | 2007-07-05 |
WO2005030095A2 (en) | 2005-04-07 |
US8137614B2 (en) | 2012-03-20 |
ES2375961T3 (en) | 2012-03-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8137614B2 (en) | Medical devices and method for making the same | |
US7938854B2 (en) | Medical devices and methods of making the same | |
JP5153634B2 (en) | Medical device having an alloy composition | |
US9402936B2 (en) | Medical devices having alloy compositions | |
US7780798B2 (en) | Medical devices including hardened alloys | |
EP1866006B1 (en) | Medical devices including composites | |
EP1604691B1 (en) | Biocompatible alloy for implantable medical devices | |
EP1604692B1 (en) | Cobalt-nickel-chromium biocompatible alloy for implantable medical devices | |
CA2511149C (en) | Improved magnetic resonance imaging compatibility alloy for implantable medical devices | |
WO2023239573A1 (en) | Processing of cobalt-tungsten alloys |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: SCIMED LIFE SYSTEMS, INC., MINNESOTA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:STINSON, JONATHAN S.;REEL/FRAME:014555/0763 Effective date: 20030922 |
|
AS | Assignment |
Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:018505/0868 Effective date: 20050101 Owner name: BOSTON SCIENTIFIC SCIMED, INC.,MINNESOTA Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:018505/0868 Effective date: 20050101 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- AFTER EXAMINER'S ANSWER OR BOARD OF APPEALS DECISION |