US20050010270A1 - Method of treating airways in the lung - Google Patents
Method of treating airways in the lung Download PDFInfo
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- US20050010270A1 US20050010270A1 US10/810,276 US81027604A US2005010270A1 US 20050010270 A1 US20050010270 A1 US 20050010270A1 US 81027604 A US81027604 A US 81027604A US 2005010270 A1 US2005010270 A1 US 2005010270A1
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- smooth muscle
- airway
- light
- treatment
- cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00541—Lung or bronchi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0604—Lungs and/or airways
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
Definitions
- the invention relates to a method and apparatus for treating smooth muscle in the walls of body conduits, and more particularly, the invention relates to a method for treating medical conditions by reducing the bulk of smooth muscle surrounding a body conduit with radiant energy treatment of the smooth muscle.
- Asthma is a disease which involves heightened reactivity of the tracheobronchial tree to numerous stimuli causing contraction of smooth muscle surrounding the airways of the lungs.
- the hyperreactivity of the airways can result from abnormal tissue reactions in the airways, which may be immunologically induced, or from a biochemical or neurohumoral imbalance of other normally functioning responses.
- the smooth muscle surrounding the airways contracts, such as when the patient coughs, to increase the localized airflow through the airways and expel inhaled particles which enter the lungs.
- the airways are hyperreactive. With these hyperreactive airways a very small amount of pollen, allergen, or other material in the air will stimulate a large amount of smooth muscle contraction or spasm.
- the hypertrophied smooth muscle expands into the airways shrinking the inner diameter of the airways for passage of air.
- a healthy person has smooth muscle thicknesses surrounding the airways of about 0.01 mm while the smooth muscle thickness in an asthma patient may enlarge to up to about 2 or 3 mm.
- the inner diameter of the airways may be reduced from about 2 to 3 mm for a healthy person to about 0.5 mm or less for an asthma patient. This narrowing of the airways causes the whistling or wheezing sound associated with asthma.
- Asthma is also characterized by the excessive secretion of mucus by glands lining the airways.
- the disease is currently treated by inhalation of bronchodilating drugs to enlarge the airways and atropine and similar compounds to reduce mucus secretion.
- Bronchodilating drugs are typically beta agonists which react with beta receptors in the smooth muscle causing the smooth muscle to relax, opening the airways.
- beta agonists which react with beta receptors in the smooth muscle causing the smooth muscle to relax, opening the airways.
- the smooth muscle is already hypertrophied and enlarged the bronchodilating drugs which cause the muscle to relax do little to increase the airway inner diameter.
- the present invention relates to a device and method for treating bodily conduits by application of radiant energy to the smooth muscle tissue of the conduit walls to prevent the smooth muscle tissue from replicating.
- the treatment of the smooth muscle tissue causes a reduction in the amount of smooth muscle tissue over time which increases the inner diameter of the body conduit and prevents smooth muscle spasms.
- an apparatus for the treatment of body conduits includes an elongated body configured to be inserted into a body conduit, the elongated body having a proximal end and a distal end, and a source of energy for emitting energy from the elongated body in an intensity which, when applied to walls of the body conduit causes a change in smooth muscle tissue which prevents the smooth muscle tissue from replicating.
- an apparatus for the treatment of walls of airways in a patient's lungs includes an elongated body configured to be inserted into the airways of a patient's lungs, the device having a proximal end and a distal end, and a source of energy for emitting energy from the distal end of the elongated body in an intensity which, when applied to the walls of the airway causes a change in smooth muscle tissue which prevents the smooth muscle tissue from replicating.
- the apparatus further includes a light transmitting fiber extending from the proximal end to the distal end of the elongated body for transmitting light from the light source into the patient's lungs, a connector on the distal end of the elongated body for connecting the elongated body to the source of light, and a light directing member positioned at a distal end of the elongated device for diffusing or redirecting the light from the light transmitting fiber in a substantially radial pattern from the distal end of the elongated device.
- a method of treating asthma to control bronchospasms includes irradiating the walls of an airway in a lung in a wavelength and intensity which causes a change in smooth muscle tissue cells and prevents the smooth muscle tissue cells from replicating, and controlling bronchospasms by reduction or elimination of smooth muscle tissue.
- a method of treating respiratory conditions to control mucus plugging includes irradiating the walls of an airway in a lung in a wavelength and intensity which causes a change in mucus gland cells and prevents the mucus gland cells from replicating, and preventing mucus plugging by reduction or elimination of mucus glands.
- a method of treating an esophagus, an ureter, or an urethra to control spasms includes irradiating the walls of a conduit to cause a change in smooth muscle cells and prevent the smooth muscle cells from replicating.
- the present invention provides advantages of a treatment for asthma or other enlargement or spasm of the smooth muscle by irradiation.
- the treatment enlarges airways, reduces or eliminates mucus plugging, and reduces or eliminates bronchospasm.
- FIG. 1 is a side cross sectional view of a body conduit and an apparatus for treating the body conduit;
- FIG. 2 is a schematic side view of lungs being treated with the treatment device
- FIG. 3 is a side cross sectional view of a distal end of a first embodiment of a treatment device according to the present invention
- FIG. 4 is a side cross sectional view of a distal end of a second embodiment of a treatment device according to the present invention.
- FIG. 5 is a side cross sectional view of a distal end of a third embodiment of a treatment device according to the present invention.
- FIG. 6 is a side cross sectional view of a fourth embodiment of a treatment device according to the present invention.
- FIG. 7 is a side cross sectional view of a fifth embodiment of a treatment device according to the present invention.
- FIG. 8 is a side cross sectional view of a sixth embodiment of a treatment device according to the present invention.
- FIG. 9 is a cross sectional view of an airway in a healthy patient.
- FIG. 10 is a cross sectional view of an airway in an asthma patient.
- FIG. 1 illustrates an energy delivery device 10 for the delivery of light energy to the walls 12 of a body conduit.
- the energy delivery device 10 includes an outer catheter or sheath 16 surrounding a light transmitting fiber 18 .
- a light directing member 20 is positioned at a distal end of the energy delivery device 10 for directing the light to the conduit walls.
- the energy delivery device 10 and method according to the present invention provide a more permanent treatment for asthma than the currently used bronchodilating drugs and drugs for reducing mucus secretion.
- the cross sectional diameter of the airways are reduced due to bulking of the smooth muscle surrounding the airways.
- FIG. 9 illustrates an airway 50 of a healthy individual. The airway is surrounded by smooth muscle tissue 52 which is capable of contracting to shrink the diameter of the airway. A plurality of mucus glands 54 are positioned around the airway 50 and secrete mucus into the airway.
- FIG. 10 illustrates an airway 60 in an asthma patient in which the smooth muscle 62 has hypertrophied increasing the thickness of the smooth muscle and reducing the inner diameter of the airway.
- the energy delivery device 10 of the present invention is used to debulk or reduce the volume of smooth muscle 62 surrounding the airway 60 of an asthma patient and increase the airway diameter for improved air exchange.
- the energy delivery device 10 is used to irradiate the smooth muscle surrounding the airways causing the DNA of the smooth muscle cells to become cross linked.
- the treated smooth muscle cells with cross linked DNA are incapable of replicating. Accordingly, over time, as the smooth muscle cells die, the total thickness of smooth muscle decreases because of the inability of the cells to replicate.
- the programmed cell death causing a reduction in the volume of tissue is called apoptosis.
- This treatment does not cause an immediate effect but causes shrinking of the smooth muscle and opening of the airway over time and substantially prevents regrowth.
- the irradiation by the energy delivery device 10 of the walls of the airway also causes a cross linking of the DNA of the mucus gland cells preventing them from replicating and reducing mucus plugging over time.
- the energy delivery device 10 is an elongated device such as a catheter containing a fiber optic.
- the energy delivery device 10 is connected by a conventional optical connection to a light source 22 .
- the treatment of an airway with the energy delivery device 10 involves placing a visualization system such as an endoscope or bronchoscope into the airways.
- the energy delivery device 10 is then inserted through or next to the bronchoscope or endoscope while visualizing the airways.
- the energy delivery device 10 which has been positioned with a distal end within an airway to be treated is energized so that radiant energy is emitted in a generally radially direction from a distal end of the energy delivery device.
- the distal end of the energy delivery device 10 is moved through the airway in a uniform painting like motion to expose the entire length of an airway to be treated to the energy.
- the energy delivery device 10 may be passed along the airway one or more times to achieve adequate treatment.
- the painting like motion used to exposed the entire length of an airway to the energy may be performed by moving the entire energy delivery device 10 from the proximal end either manually or by motor.
- the energy used may be coherent or incoherent light in the range of infrared, visible, or ultraviolet.
- the light source 22 may be any known source, such as a UV laser source.
- the light is ultraviolet light having a wavelength of about 240-280 nm or visible light in the red visible range.
- the intensity of the light may vary depending on the application.
- the light intensity should be bright enough to penetrate any mucus present in the airway and penetrate the smooth muscle cells and mucus gland cells to cause cross linking of the cell DNA.
- the light intensity may vary depending on the wavelength used, the application, the thickness of the smooth muscle, and other factors.
- a beta or gamma radiation source may be used instead of the light source as described in further detail below with respect to FIGS. 7 and 8 .
- FIGS. 3-6 illustrate different exemplary embodiments of the distal tip of the energy delivery device 10 for irradiating the airway walls.
- the sheath 16 includes a plurality of windows 24 which allow the energy which has been redirected by the light directing member 20 to pass substantially radially out of the sheath.
- the light directing member 20 is fitted into the distal end of the sheath 16 .
- the light directing member 20 is a parabolic diffusing mirror having a reflective surface 26 which is substantially parabolic in cross section. The light passes from the light source along the light transmitting fiber 18 and is reflected by the reflective surface 26 of the light directing member 20 through the windows 24 .
- the windows 24 are preferably a plurality of energy transmitting sections spaced around the distal end of the sheath.
- the windows 24 may be open bores extending through the sheath 16 .
- the windows 24 may be formed of a material transparent to the energy being used which allows the energy to pass out of the sheath 16 .
- FIG. 4 illustrates an alternative embodiment of the energy delivery device 10 in which the light directing member 20 has a conical shaped reflective surface 32 .
- This conical shaped reflective surface may be formed at any desired angle which directs the light transmitted by the light transmitting fiber 18 radially out of the sheath 16 .
- the use of a conical reflective surface 32 creates a light delivery pattern in which the light rays are directed in a generally coherent radial pattern which is at a generally fixed angle with respect to a longitudinal axis of the light delivery device.
- the light delivery device of FIG. 3 with the parabolic reflective surface 26 directs light in a diverging radial pattern which will illuminate a larger area of the airway walls.
- FIG. 5 illustrates a further alternative embodiment of the invention in which the light directing member 20 is a substantially conical member including concave reflective surfaces 36 .
- These concave reflective surfaces 36 direct the light which passes in a generally parallel arrangement through the light transmitting fiber 18 out of the sheath 16 in a converging or crossing pattern.
- the windows have been replaced by a tip 38 of the sheath 16 formed of a material which is transparent to the energy being used.
- the light directing members 20 having a reflective surface as illustrated in FIGS. 3-5 may be formed in any of the known manners, such as by coating a molded member with a reflective coating, such as aluminum or silver.
- a diffusing lens 42 such as a Teflon lens, may be positioned at the end of the light transmitting fiber 18 as illustrated schematically in FIG. 6 .
- the diffusing lens 42 may direct the light from the light transmitting fiber 18 in a generally conical pattern as shown in FIG. 6 .
- the diffusing lens 42 may direct the light in a more radially oriented pattern with the light rays being prevented from exiting the lens in a direction substantially parallel with the longitudinal axis of the light transmitting fiber 18 by a reflective or blocking member.
- the sheath 16 surrounding the light transmitting fiber 18 and the diffusing lens 42 may be eliminated entirely and the lens may be affixed directly to the end of the fiber.
- the energy delivery device 10 can be used in conjunction with photo-activatable substances such as those known as psoralens. These light activatable compounds, when activated, enhance the ability of light to cross link the DNA in the smooth muscle tissue and mucus glands.
- the light activatable compound may by injected intravenously.
- the light delivered by the light delivery device 10 is matched to the absorption spectrum of the chosen light activatable compound such that the light exposure activates the compound.
- a lower light intensity may be used to achieve cross linking of the DNA than the light intensity required to achieve cross linking without the light activatable compounds.
- FIG. 7 illustrates an alternative embodiment of an energy delivery device 10 including an elongated body or shaft 66 having a radiation source 68 positioned at the distal end of the flexible shaft.
- the radiation source 68 may be any known source of radiation such as a radioactive pellet of iridium.
- the treatment of a bodily conduit of a patient with the energy delivery device 10 of FIG. 7 is performed by moving the elongated shaft 66 back and forth in the body conduit in a painting like motion to cause a cross linking of the DNA in the smooth muscle surrounding the body conduit.
- FIG. 8 illustrates another alternative embodiment of an energy delivery device 10 having a source of radiation such as a radioactive pellet 72 positioned within a cannula 74 .
- the pellet 72 may be moved within the cannula 74 . Movement of the radioactive pellet 72 may be performed by connecting a syringe to a proximal end of the cannula 74 and injecting or withdrawing fluid through the cannula to move the pellet in a piston like manner.
- a vent port 76 is provided at the distal end of the cannula 74 to allow fluid to pass into and out of the cannula.
- the energy delivery device 10 of FIGS. 7 and 8 are preferably delivered to a treatment site within the body through a shielded cannula which prevents radiation from being emitted into surrounding tissue as the device is inserted.
- FIG. 8 In use, the embodiment of FIG. 8 is inserted to a treatment site such as an airway of the lungs through a radiation shielding cannula. A syringe filled with air is then connected to the proximal end of the cannula 74 and air is injected and withdrawn to move the radioactive pellet within the cannula 74 to expose a desired section of the airway to radiation emitted from the radioactive pellet. Once the treatment has been completed, the cannula 74 and pellet 72 are retracted inside the shielding cannula and the device is withdrawn from the patient.
- the cross linking of the smooth muscle and mucus gland DNA according to the present invention will reduce or eliminate the smooth muscle and the secreting glands such as mucus glands from the area of the airway which is treated by preventing the treated cells from replicating.
- This light treatment provides improved long term relief from asthma symptoms for some asthma sufferers.
- some amount of smooth muscle or mucus gland cells which were not affected by an initial light treatment may regenerate and treatment may have to be repeated after a period of time such as one or more months or years.
- the present treatment has been described for use in debulking enlarged smooth muscle tissue to open up the airways, it may also be used for eliminating smooth muscle altogether.
- the elimination of the smooth muscle tissue prevents the hyperreactive airways of an asthma patient from contracting or spasming, completely eliminating this asthma symptom.
- the light delivery device 10 may also be used for treatment of other conditions by reducing the volume of smooth muscle tissue surrounding other body conduits.
- the treatment system may be used for reducing smooth muscle and spasms of the esophagus of patients with achalasia or esophageal spasm, in coronary arteries of patients with Printzmetal's angina variant, for ureteral spasm, for urethral spasm, and irritable bowel disorders.
Abstract
Description
- This is a continuation of U.S. application Ser. No. 09/095,323 filed Jun. 10, 1998.
- The invention relates to a method and apparatus for treating smooth muscle in the walls of body conduits, and more particularly, the invention relates to a method for treating medical conditions by reducing the bulk of smooth muscle surrounding a body conduit with radiant energy treatment of the smooth muscle.
- Asthma is a disease which involves heightened reactivity of the tracheobronchial tree to numerous stimuli causing contraction of smooth muscle surrounding the airways of the lungs. The hyperreactivity of the airways can result from abnormal tissue reactions in the airways, which may be immunologically induced, or from a biochemical or neurohumoral imbalance of other normally functioning responses. In a healthy patient, the smooth muscle surrounding the airways contracts, such as when the patient coughs, to increase the localized airflow through the airways and expel inhaled particles which enter the lungs. In a patient with asthma, the airways are hyperreactive. With these hyperreactive airways a very small amount of pollen, allergen, or other material in the air will stimulate a large amount of smooth muscle contraction or spasm. This repeated contraction of the smooth muscles exercises the muscle causing the muscle to hypertrophy and become larger. Because the tissue surrounding the smooth muscle is relatively rigid, the hypertrophied smooth muscle expands into the airways shrinking the inner diameter of the airways for passage of air. For example, a healthy person has smooth muscle thicknesses surrounding the airways of about 0.01 mm while the smooth muscle thickness in an asthma patient may enlarge to up to about 2 or 3 mm. Correspondingly, the inner diameter of the airways may be reduced from about 2 to 3 mm for a healthy person to about 0.5 mm or less for an asthma patient. This narrowing of the airways causes the whistling or wheezing sound associated with asthma.
- Asthma is also characterized by the excessive secretion of mucus by glands lining the airways. The disease is currently treated by inhalation of bronchodilating drugs to enlarge the airways and atropine and similar compounds to reduce mucus secretion. Bronchodilating drugs are typically beta agonists which react with beta receptors in the smooth muscle causing the smooth muscle to relax, opening the airways. However, if the smooth muscle is already hypertrophied and enlarged the bronchodilating drugs which cause the muscle to relax do little to increase the airway inner diameter.
- An additional disadvantage of the inhaled asthma drugs is that these drugs must be used repeatedly and regularly. Even with regular use of asthma drugs, patients frequently require hospitalization for more intensive therapy and sometimes die from severe bronchospasms and mucus plugging.
- Accordingly, it would be desirable to provide an asthma treatment which enlarges the airways and reduces mucus plugging without the need for repetitive drug treatments.
- In addition to the airways of the lungs, other body conduits such as the esophagus, ureter, urethra, and coronary arteries, are also subject to periodic spasms which cause hypertrophy of the smooth muscle around these body conduits reducing the inner diameter of the conduits.
- The present invention relates to a device and method for treating bodily conduits by application of radiant energy to the smooth muscle tissue of the conduit walls to prevent the smooth muscle tissue from replicating. The treatment of the smooth muscle tissue causes a reduction in the amount of smooth muscle tissue over time which increases the inner diameter of the body conduit and prevents smooth muscle spasms.
- In accordance with one aspect of the present invention, an apparatus for the treatment of body conduits includes an elongated body configured to be inserted into a body conduit, the elongated body having a proximal end and a distal end, and a source of energy for emitting energy from the elongated body in an intensity which, when applied to walls of the body conduit causes a change in smooth muscle tissue which prevents the smooth muscle tissue from replicating.
- In accordance with another aspect of the present invention, an apparatus for the treatment of walls of airways in a patient's lungs includes an elongated body configured to be inserted into the airways of a patient's lungs, the device having a proximal end and a distal end, and a source of energy for emitting energy from the distal end of the elongated body in an intensity which, when applied to the walls of the airway causes a change in smooth muscle tissue which prevents the smooth muscle tissue from replicating.
- When the source of energy is a light source the apparatus further includes a light transmitting fiber extending from the proximal end to the distal end of the elongated body for transmitting light from the light source into the patient's lungs, a connector on the distal end of the elongated body for connecting the elongated body to the source of light, and a light directing member positioned at a distal end of the elongated device for diffusing or redirecting the light from the light transmitting fiber in a substantially radial pattern from the distal end of the elongated device.
- In accordance with an additional aspect of the present invention, a method of treating asthma to control bronchospasms includes irradiating the walls of an airway in a lung in a wavelength and intensity which causes a change in smooth muscle tissue cells and prevents the smooth muscle tissue cells from replicating, and controlling bronchospasms by reduction or elimination of smooth muscle tissue.
- In accordance with a further aspect of the invention, a method of treating respiratory conditions to control mucus plugging includes irradiating the walls of an airway in a lung in a wavelength and intensity which causes a change in mucus gland cells and prevents the mucus gland cells from replicating, and preventing mucus plugging by reduction or elimination of mucus glands.
- In accordance with another aspect of the present invention, a method of treating an esophagus, an ureter, or an urethra to control spasms includes irradiating the walls of a conduit to cause a change in smooth muscle cells and prevent the smooth muscle cells from replicating.
- The present invention provides advantages of a treatment for asthma or other enlargement or spasm of the smooth muscle by irradiation. The treatment enlarges airways, reduces or eliminates mucus plugging, and reduces or eliminates bronchospasm.
- The invention will now be described in greater detail with reference to the preferred embodiments illustrated in the accompanying drawings, in which like elements bear like reference numerals, and wherein:
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FIG. 1 is a side cross sectional view of a body conduit and an apparatus for treating the body conduit; -
FIG. 2 is a schematic side view of lungs being treated with the treatment device; -
FIG. 3 is a side cross sectional view of a distal end of a first embodiment of a treatment device according to the present invention; -
FIG. 4 is a side cross sectional view of a distal end of a second embodiment of a treatment device according to the present invention; -
FIG. 5 is a side cross sectional view of a distal end of a third embodiment of a treatment device according to the present invention; -
FIG. 6 is a side cross sectional view of a fourth embodiment of a treatment device according to the present invention; -
FIG. 7 is a side cross sectional view of a fifth embodiment of a treatment device according to the present invention; -
FIG. 8 is a side cross sectional view of a sixth embodiment of a treatment device according to the present invention; -
FIG. 9 is a cross sectional view of an airway in a healthy patient; and -
FIG. 10 is a cross sectional view of an airway in an asthma patient. -
FIG. 1 illustrates anenergy delivery device 10 for the delivery of light energy to thewalls 12 of a body conduit. Theenergy delivery device 10 includes an outer catheter orsheath 16 surrounding a light transmittingfiber 18. A light directingmember 20 is positioned at a distal end of theenergy delivery device 10 for directing the light to the conduit walls. Although the present invention will be described in detail with respect to the treatment of airways in the lungs, it should be understood that the present invention may also be used for treatment of other body conduits. - The
energy delivery device 10 and method according to the present invention provide a more permanent treatment for asthma than the currently used bronchodilating drugs and drugs for reducing mucus secretion. In asthma patients, the cross sectional diameter of the airways are reduced due to bulking of the smooth muscle surrounding the airways.FIG. 9 illustrates anairway 50 of a healthy individual. The airway is surrounded bysmooth muscle tissue 52 which is capable of contracting to shrink the diameter of the airway. A plurality ofmucus glands 54 are positioned around theairway 50 and secrete mucus into the airway.FIG. 10 illustrates anairway 60 in an asthma patient in which thesmooth muscle 62 has hypertrophied increasing the thickness of the smooth muscle and reducing the inner diameter of the airway. Theenergy delivery device 10 of the present invention is used to debulk or reduce the volume ofsmooth muscle 62 surrounding theairway 60 of an asthma patient and increase the airway diameter for improved air exchange. - The
energy delivery device 10 is used to irradiate the smooth muscle surrounding the airways causing the DNA of the smooth muscle cells to become cross linked. The treated smooth muscle cells with cross linked DNA are incapable of replicating. Accordingly, over time, as the smooth muscle cells die, the total thickness of smooth muscle decreases because of the inability of the cells to replicate. The programmed cell death causing a reduction in the volume of tissue is called apoptosis. This treatment does not cause an immediate effect but causes shrinking of the smooth muscle and opening of the airway over time and substantially prevents regrowth. The irradiation by theenergy delivery device 10 of the walls of the airway also causes a cross linking of the DNA of the mucus gland cells preventing them from replicating and reducing mucus plugging over time. - As shown in
FIG. 2 , theenergy delivery device 10 is an elongated device such as a catheter containing a fiber optic. Theenergy delivery device 10 is connected by a conventional optical connection to alight source 22. The treatment of an airway with theenergy delivery device 10 involves placing a visualization system such as an endoscope or bronchoscope into the airways. Theenergy delivery device 10 is then inserted through or next to the bronchoscope or endoscope while visualizing the airways. Theenergy delivery device 10 which has been positioned with a distal end within an airway to be treated is energized so that radiant energy is emitted in a generally radially direction from a distal end of the energy delivery device. The distal end of theenergy delivery device 10 is moved through the airway in a uniform painting like motion to expose the entire length of an airway to be treated to the energy. Theenergy delivery device 10 may be passed along the airway one or more times to achieve adequate treatment. The painting like motion used to exposed the entire length of an airway to the energy may be performed by moving the entireenergy delivery device 10 from the proximal end either manually or by motor. - The energy used may be coherent or incoherent light in the range of infrared, visible, or ultraviolet. The
light source 22 may be any known source, such as a UV laser source. Preferably the light is ultraviolet light having a wavelength of about 240-280 nm or visible light in the red visible range. The intensity of the light may vary depending on the application. The light intensity should be bright enough to penetrate any mucus present in the airway and penetrate the smooth muscle cells and mucus gland cells to cause cross linking of the cell DNA. The light intensity may vary depending on the wavelength used, the application, the thickness of the smooth muscle, and other factors. Alternatively, a beta or gamma radiation source may be used instead of the light source as described in further detail below with respect toFIGS. 7 and 8 . -
FIGS. 3-6 illustrate different exemplary embodiments of the distal tip of theenergy delivery device 10 for irradiating the airway walls. InFIG. 3 , thesheath 16 includes a plurality ofwindows 24 which allow the energy which has been redirected by thelight directing member 20 to pass substantially radially out of the sheath. Thelight directing member 20 is fitted into the distal end of thesheath 16. Thelight directing member 20 is a parabolic diffusing mirror having areflective surface 26 which is substantially parabolic in cross section. The light passes from the light source along thelight transmitting fiber 18 and is reflected by thereflective surface 26 of thelight directing member 20 through thewindows 24. Thewindows 24 are preferably a plurality of energy transmitting sections spaced around the distal end of the sheath. Thewindows 24 may be open bores extending through thesheath 16. Alternatively, thewindows 24 may be formed of a material transparent to the energy being used which allows the energy to pass out of thesheath 16. -
FIG. 4 illustrates an alternative embodiment of theenergy delivery device 10 in which thelight directing member 20 has a conical shapedreflective surface 32. This conical shaped reflective surface may be formed at any desired angle which directs the light transmitted by thelight transmitting fiber 18 radially out of thesheath 16. The use of a conicalreflective surface 32 creates a light delivery pattern in which the light rays are directed in a generally coherent radial pattern which is at a generally fixed angle with respect to a longitudinal axis of the light delivery device. In contrast, the light delivery device ofFIG. 3 with the parabolicreflective surface 26 directs light in a diverging radial pattern which will illuminate a larger area of the airway walls. -
FIG. 5 illustrates a further alternative embodiment of the invention in which thelight directing member 20 is a substantially conical member including concave reflective surfaces 36. These concavereflective surfaces 36 direct the light which passes in a generally parallel arrangement through thelight transmitting fiber 18 out of thesheath 16 in a converging or crossing pattern. In addition, in the embodiment ofFIG. 5 , the windows have been replaced by atip 38 of thesheath 16 formed of a material which is transparent to the energy being used. - The
light directing members 20 having a reflective surface as illustrated inFIGS. 3-5 may be formed in any of the known manners, such as by coating a molded member with a reflective coating, such as aluminum or silver. - As an alternative to the reflective light directing members of
FIGS. 3-5 , a diffusinglens 42, such as a Teflon lens, may be positioned at the end of thelight transmitting fiber 18 as illustrated schematically inFIG. 6 . The diffusinglens 42 may direct the light from thelight transmitting fiber 18 in a generally conical pattern as shown inFIG. 6 . Alternatively, the diffusinglens 42 may direct the light in a more radially oriented pattern with the light rays being prevented from exiting the lens in a direction substantially parallel with the longitudinal axis of thelight transmitting fiber 18 by a reflective or blocking member. In the embodiment ofFIG. 6 , thesheath 16 surrounding thelight transmitting fiber 18 and the diffusinglens 42 may be eliminated entirely and the lens may be affixed directly to the end of the fiber. - According to one alternative embodiment of the invention, the
energy delivery device 10 can be used in conjunction with photo-activatable substances such as those known as psoralens. These light activatable compounds, when activated, enhance the ability of light to cross link the DNA in the smooth muscle tissue and mucus glands. The light activatable compound may by injected intravenously. The light delivered by thelight delivery device 10 is matched to the absorption spectrum of the chosen light activatable compound such that the light exposure activates the compound. When such light activatable substances are employed, a lower light intensity may be used to achieve cross linking of the DNA than the light intensity required to achieve cross linking without the light activatable compounds. -
FIG. 7 illustrates an alternative embodiment of anenergy delivery device 10 including an elongated body orshaft 66 having aradiation source 68 positioned at the distal end of the flexible shaft. Theradiation source 68 may be any known source of radiation such as a radioactive pellet of iridium. The treatment of a bodily conduit of a patient with theenergy delivery device 10 ofFIG. 7 is performed by moving theelongated shaft 66 back and forth in the body conduit in a painting like motion to cause a cross linking of the DNA in the smooth muscle surrounding the body conduit. -
FIG. 8 illustrates another alternative embodiment of anenergy delivery device 10 having a source of radiation such as aradioactive pellet 72 positioned within acannula 74. According to this embodiment, in addition to moving the cannula itself to achieve a painting action within a body conduit, thepellet 72 may be moved within thecannula 74. Movement of theradioactive pellet 72 may be performed by connecting a syringe to a proximal end of thecannula 74 and injecting or withdrawing fluid through the cannula to move the pellet in a piston like manner. Avent port 76 is provided at the distal end of thecannula 74 to allow fluid to pass into and out of the cannula. In use, theenergy delivery device 10 ofFIGS. 7 and 8 are preferably delivered to a treatment site within the body through a shielded cannula which prevents radiation from being emitted into surrounding tissue as the device is inserted. - In use, the embodiment of
FIG. 8 is inserted to a treatment site such as an airway of the lungs through a radiation shielding cannula. A syringe filled with air is then connected to the proximal end of thecannula 74 and air is injected and withdrawn to move the radioactive pellet within thecannula 74 to expose a desired section of the airway to radiation emitted from the radioactive pellet. Once the treatment has been completed, thecannula 74 andpellet 72 are retracted inside the shielding cannula and the device is withdrawn from the patient. - The cross linking of the smooth muscle and mucus gland DNA according to the present invention will reduce or eliminate the smooth muscle and the secreting glands such as mucus glands from the area of the airway which is treated by preventing the treated cells from replicating. This light treatment provides improved long term relief from asthma symptoms for some asthma sufferers. However, over time, some amount of smooth muscle or mucus gland cells which were not affected by an initial light treatment may regenerate and treatment may have to be repeated after a period of time such as one or more months or years.
- Although the present treatment has been described for use in debulking enlarged smooth muscle tissue to open up the airways, it may also be used for eliminating smooth muscle altogether. The elimination of the smooth muscle tissue prevents the hyperreactive airways of an asthma patient from contracting or spasming, completely eliminating this asthma symptom.
- The
light delivery device 10 may also be used for treatment of other conditions by reducing the volume of smooth muscle tissue surrounding other body conduits. For example, the treatment system may be used for reducing smooth muscle and spasms of the esophagus of patients with achalasia or esophageal spasm, in coronary arteries of patients with Printzmetal's angina variant, for ureteral spasm, for urethral spasm, and irritable bowel disorders. - While the invention has been described in detail with reference to the preferred embodiments thereof, it will be apparent to one skilled in the art that various changes and modifications can be made and equivalents employed, without departing from the present invention.
Claims (15)
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Cited By (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030159700A1 (en) * | 1997-04-07 | 2003-08-28 | Laufer Michael D. | Method of increasing gas exchange of a lung |
US20040031494A1 (en) * | 1998-06-10 | 2004-02-19 | Broncus Technologies, Inc. | Methods of treating asthma |
US20050187579A1 (en) * | 1997-04-07 | 2005-08-25 | Asthmatx, Inc. | Method for treating an asthma attack |
US6994702B1 (en) * | 1999-04-06 | 2006-02-07 | Kci Licensing, Inc. | Vacuum assisted closure pad with adaptation for phototherapy |
US20060062808A1 (en) * | 2004-09-18 | 2006-03-23 | Asthmatx, Inc. | Inactivation of smooth muscle tissue |
US20060173253A1 (en) * | 1999-04-06 | 2006-08-03 | Kci Licensing, Inc. | Systems and methods for detection of wound fluid blood and application of phototherapy in conjunction with reduced pressure wound treatment system |
US20060222667A1 (en) * | 2003-05-13 | 2006-10-05 | The Foundry, Inc. | Apparatus for treating asthma using neurotoxin |
US20060247683A1 (en) * | 2005-04-21 | 2006-11-02 | Asthmatx, Inc. | Control systems for delivering energy |
US20060247617A1 (en) * | 2004-11-12 | 2006-11-02 | Asthmatx, Inc. | Energy delivery devices and methods |
US20060247726A1 (en) * | 2000-10-17 | 2006-11-02 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
US20060247618A1 (en) * | 2004-11-05 | 2006-11-02 | Asthmatx, Inc. | Medical device with procedure improvement features |
US20070083197A1 (en) * | 1998-01-07 | 2007-04-12 | Asthmatx, Inc. | Method for treating an asthma attack |
US20070106339A1 (en) * | 2005-11-10 | 2007-05-10 | Electrocore, Inc. | Electrical stimulation treatment of bronchial constriction |
US20070102011A1 (en) * | 1998-06-10 | 2007-05-10 | Asthmatx, Inc. | Methods of evaluating individuals having reversible obstructive pulmonary disease |
US20070106292A1 (en) * | 2004-11-05 | 2007-05-10 | Asthmatx, Inc. | Energy delivery devices and methods |
US20070118184A1 (en) * | 1998-06-10 | 2007-05-24 | Asthmatx, Inc. | Devices for modification of airways by transfer of energy |
US20070123958A1 (en) * | 1998-06-10 | 2007-05-31 | Asthmatx, Inc. | Apparatus for treating airways in the lung |
US20070191905A1 (en) * | 2006-02-10 | 2007-08-16 | Electrocore, Inc. | Electrical stimulation treatment of hypotension |
US20070191902A1 (en) * | 2006-02-10 | 2007-08-16 | Electrocore, Inc. | Methods and apparatus for treating anaphylaxis using electrical modulation |
US20080097424A1 (en) * | 2006-10-20 | 2008-04-24 | Asthmatx, Inc. | Electrode markers and methods of use |
US20080183237A1 (en) * | 2006-04-18 | 2008-07-31 | Electrocore, Inc. | Methods And Apparatus For Treating Ileus Condition Using Electrical Signals |
US20090018538A1 (en) * | 2007-07-12 | 2009-01-15 | Asthmatx, Inc. | Systems and methods for delivering energy to passageways in a patient |
US20090030477A1 (en) * | 2007-07-24 | 2009-01-29 | Asthmatx, Inc. | System and method for controlling power based on impedance detection, such as controlling power to tissue treatment devices |
US20090043301A1 (en) * | 2007-08-09 | 2009-02-12 | Asthmatx, Inc. | Monopolar energy delivery devices and methods for controlling current density in tissue |
US20090187231A1 (en) * | 2005-11-10 | 2009-07-23 | Electrocore, Inc. | Electrical Treatment Of Bronchial Constriction |
US20090306644A1 (en) * | 2008-05-09 | 2009-12-10 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US20100057178A1 (en) * | 2006-04-18 | 2010-03-04 | Electrocore, Inc. | Methods and apparatus for spinal cord stimulation using expandable electrode |
US20100114261A1 (en) * | 2006-02-10 | 2010-05-06 | Electrocore Llc | Electrical Stimulation Treatment of Hypotension |
US20100179424A1 (en) * | 2009-01-09 | 2010-07-15 | Reinhard Warnking | Methods and apparatus for treatment of mitral valve insufficiency |
US20100241188A1 (en) * | 2009-03-20 | 2010-09-23 | Electrocore, Inc. | Percutaneous Electrical Treatment Of Tissue |
US20110118725A1 (en) * | 2009-11-11 | 2011-05-19 | Mayse Martin L | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US20110125203A1 (en) * | 2009-03-20 | 2011-05-26 | ElectroCore, LLC. | Magnetic Stimulation Devices and Methods of Therapy |
US20110152855A1 (en) * | 2009-10-27 | 2011-06-23 | Mayse Martin L | Delivery devices with coolable energy emitting assemblies |
US8181656B2 (en) | 1998-06-10 | 2012-05-22 | Asthmatx, Inc. | Methods for treating airways |
US8251070B2 (en) | 2000-03-27 | 2012-08-28 | Asthmatx, Inc. | Methods for treating airways |
US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
WO2014071372A1 (en) | 2012-11-05 | 2014-05-08 | Boston Scientific Scimed, Inc. | Devices for delivering energy to body lumens |
US8840537B2 (en) | 2005-11-10 | 2014-09-23 | ElectroCore, LLC | Non-invasive treatment of bronchial constriction |
US9149328B2 (en) | 2009-11-11 | 2015-10-06 | Holaira, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
US9272132B2 (en) | 2012-11-02 | 2016-03-01 | Boston Scientific Scimed, Inc. | Medical device for treating airways and related methods of use |
US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
US9592086B2 (en) | 2012-07-24 | 2017-03-14 | Boston Scientific Scimed, Inc. | Electrodes for tissue treatment |
US9700372B2 (en) | 2002-07-01 | 2017-07-11 | Recor Medical, Inc. | Intraluminal methods of ablating nerve tissue |
US9770293B2 (en) | 2012-06-04 | 2017-09-26 | Boston Scientific Scimed, Inc. | Systems and methods for treating tissue of a passageway within a body |
US9814618B2 (en) | 2013-06-06 | 2017-11-14 | Boston Scientific Scimed, Inc. | Devices for delivering energy and related methods of use |
US9950188B2 (en) | 2012-05-31 | 2018-04-24 | Color Seven Co., Ltd. | Apparatus for relaxing smooth muscles of human body |
US10478247B2 (en) | 2013-08-09 | 2019-11-19 | Boston Scientific Scimed, Inc. | Expandable catheter and related methods of manufacture and use |
US10702337B2 (en) | 2016-06-27 | 2020-07-07 | Galary, Inc. | Methods, apparatuses, and systems for the treatment of pulmonary disorders |
Families Citing this family (170)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6053172A (en) * | 1995-06-07 | 2000-04-25 | Arthrocare Corporation | Systems and methods for electrosurgical sinus surgery |
US5957920A (en) * | 1997-08-28 | 1999-09-28 | Isothermix, Inc. | Medical instruments and techniques for treatment of urinary incontinence |
US6740082B2 (en) | 1998-12-29 | 2004-05-25 | John H. Shadduck | Surgical instruments for treating gastro-esophageal reflux |
EP0979635A2 (en) | 1998-08-12 | 2000-02-16 | Origin Medsystems, Inc. | Tissue dissector apparatus |
US6464625B2 (en) * | 1999-06-23 | 2002-10-15 | Robert A. Ganz | Therapeutic method and apparatus for debilitating or killing microorganisms within the body |
US8474460B2 (en) | 2000-03-04 | 2013-07-02 | Pulmonx Corporation | Implanted bronchial isolation devices and methods |
US6719778B1 (en) * | 2000-03-24 | 2004-04-13 | Endovascular Technologies, Inc. | Methods for treatment of aneurysms |
US6527761B1 (en) | 2000-10-27 | 2003-03-04 | Pulmonx, Inc. | Methods and devices for obstructing and aspirating lung tissue segments |
US6558313B1 (en) | 2000-11-17 | 2003-05-06 | Embro Corporation | Vein harvesting system and method |
US6558410B1 (en) * | 2000-11-28 | 2003-05-06 | Remotelight, Inc. | Cardiac deblocking device and method |
US6994706B2 (en) * | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
US7883471B2 (en) | 2001-09-10 | 2011-02-08 | Pulmonx Corporation | Minimally invasive determination of collateral ventilation in lungs |
EP1435833B1 (en) | 2001-09-10 | 2014-05-21 | Pulmonx | Apparatus for endobronchial diagnosis |
US20030050648A1 (en) | 2001-09-11 | 2003-03-13 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US6592594B2 (en) | 2001-10-25 | 2003-07-15 | Spiration, Inc. | Bronchial obstruction device deployment system and method |
US7004941B2 (en) * | 2001-11-08 | 2006-02-28 | Arthrocare Corporation | Systems and methods for electrosurigical treatment of obstructive sleep disorders |
US20030216769A1 (en) | 2002-05-17 | 2003-11-20 | Dillard David H. | Removable anchored lung volume reduction devices and methods |
US20030181922A1 (en) | 2002-03-20 | 2003-09-25 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
AU2003221744A1 (en) * | 2002-04-19 | 2003-11-03 | Broncus Technologies, Inc. | Devices for maintaining surgically created openings |
EP1524942B1 (en) | 2002-07-26 | 2008-09-10 | Emphasys Medical, Inc. | Bronchial flow control devices with membrane seal |
DE10252325B4 (en) * | 2002-11-11 | 2012-10-25 | Admedes Schuessler Gmbh | Radiofrequency thermal ablation probe and method of making the same |
US20040153056A1 (en) * | 2002-11-11 | 2004-08-05 | Berchtold Holding Gmbh, A German Corporation | Probe |
US7814912B2 (en) | 2002-11-27 | 2010-10-19 | Pulmonx Corporation | Delivery methods and devices for implantable bronchial isolation devices |
EP1596805A2 (en) * | 2003-01-15 | 2005-11-23 | Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California | Treatments for snoring using injectable neuromuscular stimulators |
US7686802B2 (en) * | 2003-03-28 | 2010-03-30 | C.R. Bard, Inc. | Junction of catheter tip and electrode |
US7811274B2 (en) * | 2003-05-07 | 2010-10-12 | Portaero, Inc. | Method for treating chronic obstructive pulmonary disease |
US7426929B2 (en) | 2003-05-20 | 2008-09-23 | Portaero, Inc. | Intra/extra-thoracic collateral ventilation bypass system and method |
US20040236231A1 (en) * | 2003-05-23 | 2004-11-25 | Embro Corporation | Light catheter for illuminating tissue structures |
DE10349710A1 (en) * | 2003-05-28 | 2004-12-16 | HELBO Medizintechnik GmbH | Arrangement for the reduction of microorganisms |
US7533667B2 (en) | 2003-05-29 | 2009-05-19 | Portaero, Inc. | Methods and devices to assist pulmonary decompression |
US7252086B2 (en) | 2003-06-03 | 2007-08-07 | Cordis Corporation | Lung reduction system |
US7377278B2 (en) | 2003-06-05 | 2008-05-27 | Portaero, Inc. | Intra-thoracic collateral ventilation bypass system and method |
US7682332B2 (en) | 2003-07-15 | 2010-03-23 | Portaero, Inc. | Methods to accelerate wound healing in thoracic anastomosis applications |
US8308682B2 (en) | 2003-07-18 | 2012-11-13 | Broncus Medical Inc. | Devices for maintaining patency of surgically created channels in tissue |
US7533671B2 (en) | 2003-08-08 | 2009-05-19 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US20050256553A1 (en) * | 2004-02-09 | 2005-11-17 | John Strisower | Method and apparatus for the treatment of respiratory and other infections using ultraviolet germicidal irradiation |
US7117955B2 (en) * | 2004-02-28 | 2006-10-10 | Bellsouth Intellectual Property Corporation | Driver cap |
US7670282B2 (en) | 2004-06-14 | 2010-03-02 | Pneumrx, Inc. | Lung access device |
WO2006009688A2 (en) | 2004-06-16 | 2006-01-26 | Pneumrx, Inc. | Intra-bronchial lung volume reduction system |
EP1773227B1 (en) | 2004-06-24 | 2016-04-13 | ArthroCare Corporation | Electrosurgical device having planar vertical electrodes |
US7766891B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Lung device with sealing features |
EP1781182B1 (en) | 2004-07-08 | 2019-11-13 | PneumRx, Inc. | Pleural effusion treatment device |
US8409167B2 (en) | 2004-07-19 | 2013-04-02 | Broncus Medical Inc | Devices for delivering substances through an extra-anatomic opening created in an airway |
US7200445B1 (en) * | 2005-10-21 | 2007-04-03 | Asthmatx, Inc. | Energy delivery devices and methods |
EP1817073B1 (en) * | 2004-11-12 | 2018-01-17 | Boston Scientific Scimed, Inc. | Improved energy delivery devices |
JP5020824B2 (en) * | 2004-11-16 | 2012-09-05 | ロバート・エル・バリー | Lung therapy apparatus and method |
US7398782B2 (en) | 2004-11-19 | 2008-07-15 | Portaero, Inc. | Method for pulmonary drug delivery |
US8220460B2 (en) | 2004-11-19 | 2012-07-17 | Portaero, Inc. | Evacuation device and method for creating a localized pleurodesis |
US7771472B2 (en) | 2004-11-19 | 2010-08-10 | Pulmonx Corporation | Bronchial flow control devices and methods of use |
US9211181B2 (en) | 2004-11-19 | 2015-12-15 | Pulmonx Corporation | Implant loading device and system |
JP4874259B2 (en) | 2004-11-23 | 2012-02-15 | ヌームアールエックス・インコーポレーテッド | Steerable device for accessing the target site |
US7824366B2 (en) | 2004-12-10 | 2010-11-02 | Portaero, Inc. | Collateral ventilation device with chest tube/evacuation features and method |
US8496006B2 (en) | 2005-01-20 | 2013-07-30 | Pulmonx Corporation | Methods and devices for passive residual lung volume reduction and functional lung volume expansion |
US11883029B2 (en) | 2005-01-20 | 2024-01-30 | Pulmonx Corporation | Methods and devices for passive residual lung volume reduction and functional lung volume expansion |
US20080228137A1 (en) | 2007-03-12 | 2008-09-18 | Pulmonx | Methods and devices for passive residual lung volume reduction and functional lung volume expansion |
US8876791B2 (en) | 2005-02-25 | 2014-11-04 | Pulmonx Corporation | Collateral pathway treatment using agent entrained by aspiration flow current |
US20060234766A1 (en) * | 2005-04-19 | 2006-10-19 | Cox Communications, Inc. | Methods and systems for providing wireless information transportation using dual frequencies |
JP5826450B2 (en) | 2005-07-22 | 2015-12-02 | ザ ファウンドリー, エルエルシー | Systems and methods for delivery of therapeutic agents |
US7628789B2 (en) | 2005-08-17 | 2009-12-08 | Pulmonx Corporation | Selective lung tissue ablation |
US8104474B2 (en) | 2005-08-23 | 2012-01-31 | Portaero, Inc. | Collateral ventilation bypass system with retention features |
US8523782B2 (en) | 2005-12-07 | 2013-09-03 | Pulmonx Corporation | Minimally invasive determination of collateral ventilation in lungs |
EP1962869B1 (en) * | 2005-12-21 | 2013-03-20 | SolAeroMed Inc. | Treatment of respiratory diseases |
US7406963B2 (en) | 2006-01-17 | 2008-08-05 | Portaero, Inc. | Variable resistance pulmonary ventilation bypass valve and method |
US8157837B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US7691151B2 (en) | 2006-03-31 | 2010-04-06 | Spiration, Inc. | Articulable Anchor |
US9770230B2 (en) | 2006-06-01 | 2017-09-26 | Maquet Cardiovascular Llc | Endoscopic vessel harvesting system components |
US7993323B2 (en) | 2006-11-13 | 2011-08-09 | Uptake Medical Corp. | High pressure and high temperature vapor catheters and systems |
US20100217347A1 (en) * | 2006-12-16 | 2010-08-26 | Greatbatch, Inc. | Neurostimulation for the treatment of pulmonary disorders |
US20080183248A1 (en) * | 2007-01-17 | 2008-07-31 | The Cleveland Clinic Foundation | Apparatus and methods for treating pulmonary conditions |
US8163034B2 (en) | 2007-05-11 | 2012-04-24 | Portaero, Inc. | Methods and devices to create a chemically and/or mechanically localized pleurodesis |
US7931641B2 (en) * | 2007-05-11 | 2011-04-26 | Portaero, Inc. | Visceral pleura ring connector |
US20080287878A1 (en) * | 2007-05-15 | 2008-11-20 | Portaero, Inc. | Pulmonary visceral pleura anastomosis reinforcement |
US8062315B2 (en) | 2007-05-17 | 2011-11-22 | Portaero, Inc. | Variable parietal/visceral pleural coupling |
US8983609B2 (en) | 2007-05-30 | 2015-03-17 | The Cleveland Clinic Foundation | Apparatus and method for treating pulmonary conditions |
EP2194933B1 (en) | 2007-10-12 | 2016-05-04 | Spiration, Inc. | Valve loader method, system, and apparatus |
US8322335B2 (en) | 2007-10-22 | 2012-12-04 | Uptake Medical Corp. | Determining patient-specific vapor treatment and delivery parameters |
US8155744B2 (en) * | 2007-12-13 | 2012-04-10 | The Cleveland Clinic Foundation | Neuromodulatory methods for treating pulmonary disorders |
US20090171283A1 (en) * | 2007-12-27 | 2009-07-02 | Cook Incorporated | Method of bonding a dilation element to a surface of an angioplasty balloon |
US8475389B2 (en) | 2008-02-19 | 2013-07-02 | Portaero, Inc. | Methods and devices for assessment of pneumostoma function |
US8336540B2 (en) | 2008-02-19 | 2012-12-25 | Portaero, Inc. | Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease |
WO2009105432A2 (en) | 2008-02-19 | 2009-08-27 | Portaero, Inc. | Devices and methods for delivery of a therapeutic agent through a pneumostoma |
US8083733B2 (en) | 2008-04-16 | 2011-12-27 | Icecure Medical Ltd. | Cryosurgical instrument with enhanced heat exchange |
AU2009243079A1 (en) | 2008-04-29 | 2009-11-05 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation to create tissue scaffolds |
US10448989B2 (en) | 2009-04-09 | 2019-10-22 | Virginia Tech Intellectual Properties, Inc. | High-frequency electroporation for cancer therapy |
US10702326B2 (en) | 2011-07-15 | 2020-07-07 | Virginia Tech Intellectual Properties, Inc. | Device and method for electroporation based treatment of stenosis of a tubular body part |
US10245098B2 (en) | 2008-04-29 | 2019-04-02 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
US10272178B2 (en) | 2008-04-29 | 2019-04-30 | Virginia Tech Intellectual Properties Inc. | Methods for blood-brain barrier disruption using electrical energy |
US10238447B2 (en) | 2008-04-29 | 2019-03-26 | Virginia Tech Intellectual Properties, Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
US11254926B2 (en) | 2008-04-29 | 2022-02-22 | Virginia Tech Intellectual Properties, Inc. | Devices and methods for high frequency electroporation |
US10117707B2 (en) | 2008-04-29 | 2018-11-06 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
US11272979B2 (en) | 2008-04-29 | 2022-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
US9283051B2 (en) | 2008-04-29 | 2016-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating a treatment volume for administering electrical-energy based therapies |
US8992517B2 (en) | 2008-04-29 | 2015-03-31 | Virginia Tech Intellectual Properties Inc. | Irreversible electroporation to treat aberrant cell masses |
US9867652B2 (en) | 2008-04-29 | 2018-01-16 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds |
US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
WO2010019481A1 (en) | 2008-08-11 | 2010-02-18 | Conceptx Medical, Inc. | Systems and methods for treating dyspnea, including via electrical afferent signal blocking |
US9173669B2 (en) | 2008-09-12 | 2015-11-03 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US8347881B2 (en) | 2009-01-08 | 2013-01-08 | Portaero, Inc. | Pneumostoma management device with integrated patency sensor and method |
US7967814B2 (en) | 2009-02-05 | 2011-06-28 | Icecure Medical Ltd. | Cryoprobe with vibrating mechanism |
US8518053B2 (en) | 2009-02-11 | 2013-08-27 | Portaero, Inc. | Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease |
WO2010105158A1 (en) | 2009-03-12 | 2010-09-16 | Icecure Medical Ltd. | Combined cryotherapy and brachytherapy device and method |
US8632534B2 (en) * | 2009-04-03 | 2014-01-21 | Angiodynamics, Inc. | Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD) |
US20100256630A1 (en) * | 2009-04-07 | 2010-10-07 | Angiodynamics, Inc. | Irreversible electroporation (ire) for esophageal disease |
US11638603B2 (en) | 2009-04-09 | 2023-05-02 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
US11382681B2 (en) | 2009-04-09 | 2022-07-12 | Virginia Tech Intellectual Properties, Inc. | Device and methods for delivery of high frequency electrical pulses for non-thermal ablation |
CN104622599B (en) | 2009-05-18 | 2017-04-12 | 纽姆克斯股份有限公司 | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US8903488B2 (en) | 2009-05-28 | 2014-12-02 | Angiodynamics, Inc. | System and method for synchronizing energy delivery to the cardiac rhythm |
US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
EP2496165B1 (en) * | 2009-11-04 | 2017-01-11 | Emcision Limited | Lumenal remodelling device |
US7967815B1 (en) | 2010-03-25 | 2011-06-28 | Icecure Medical Ltd. | Cryosurgical instrument with enhanced heat transfer |
US7938822B1 (en) | 2010-05-12 | 2011-05-10 | Icecure Medical Ltd. | Heating and cooling of cryosurgical instrument using a single cryogen |
US8080005B1 (en) | 2010-06-10 | 2011-12-20 | Icecure Medical Ltd. | Closed loop cryosurgical pressure and flow regulated system |
US9700368B2 (en) | 2010-10-13 | 2017-07-11 | Angiodynamics, Inc. | System and method for electrically ablating tissue of a patient |
US10448992B2 (en) | 2010-10-22 | 2019-10-22 | Arthrocare Corporation | Electrosurgical system with device specific operational parameters |
US8747401B2 (en) | 2011-01-20 | 2014-06-10 | Arthrocare Corporation | Systems and methods for turbinate reduction |
US9168082B2 (en) | 2011-02-09 | 2015-10-27 | Arthrocare Corporation | Fine dissection electrosurgical device |
US9271784B2 (en) | 2011-02-09 | 2016-03-01 | Arthrocare Corporation | Fine dissection electrosurgical device |
US9011428B2 (en) | 2011-03-02 | 2015-04-21 | Arthrocare Corporation | Electrosurgical device with internal digestor electrode |
US9084859B2 (en) | 2011-03-14 | 2015-07-21 | Sleepnea Llc | Energy-harvesting respiratory method and device |
ES2864589T3 (en) | 2011-04-12 | 2021-10-14 | Thermedical Inc | Devices for conformal therapy in fluid-enhanced ablation |
US8709034B2 (en) | 2011-05-13 | 2014-04-29 | Broncus Medical Inc. | Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall |
JP2014521381A (en) | 2011-05-13 | 2014-08-28 | ブロンカス テクノロジーズ, インコーポレイテッド | Methods and devices for tissue ablation |
US8909316B2 (en) * | 2011-05-18 | 2014-12-09 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method of assessing transvascular denervation |
WO2013016437A2 (en) | 2011-07-25 | 2013-01-31 | Neurosave, Inc. | Non-invasive systems, devices, and methods for selective brain cooling |
US9788882B2 (en) | 2011-09-08 | 2017-10-17 | Arthrocare Corporation | Plasma bipolar forceps |
US9078665B2 (en) | 2011-09-28 | 2015-07-14 | Angiodynamics, Inc. | Multiple treatment zone ablation probe |
WO2013052501A1 (en) | 2011-10-05 | 2013-04-11 | Innovative Pulmonary Solutions, Inc. | Apparatus for injuring nerve tissue |
WO2013078235A1 (en) | 2011-11-23 | 2013-05-30 | Broncus Medical Inc | Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall |
JP2015503954A (en) | 2011-12-15 | 2015-02-05 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォードジュニア ユニバーシティThe Board of Trustees of the Leland Stanford Junior University | Apparatus and method for treating pulmonary hypertension |
DE112013002175T5 (en) | 2012-04-24 | 2015-01-22 | Cibiem, Inc. | Endovascular catheters and procedures for ablation of the carotid body |
US9402677B2 (en) | 2012-06-01 | 2016-08-02 | Cibiem, Inc. | Methods and devices for cryogenic carotid body ablation |
EP2854681A4 (en) | 2012-06-01 | 2016-02-17 | Cibiem Inc | Percutaneous methods and devices for carotid body ablation |
US8951296B2 (en) * | 2012-06-29 | 2015-02-10 | Medtronic Ardian Luxembourg S.A.R.L. | Devices and methods for photodynamically modulating neural function in a human |
US9283033B2 (en) | 2012-06-30 | 2016-03-15 | Cibiem, Inc. | Carotid body ablation via directed energy |
US10022176B2 (en) | 2012-08-15 | 2018-07-17 | Thermedical, Inc. | Low profile fluid enhanced ablation therapy devices and methods |
US9827036B2 (en) | 2012-11-13 | 2017-11-28 | Pulnovo Medical (Wuxi) Co., Ltd. | Multi-pole synchronous pulmonary artery radiofrequency ablation catheter |
CN102908191A (en) | 2012-11-13 | 2013-02-06 | 陈绍良 | Multipolar synchronous pulmonary artery radiofrequency ablation catheter |
US11241267B2 (en) | 2012-11-13 | 2022-02-08 | Pulnovo Medical (Wuxi) Co., Ltd | Multi-pole synchronous pulmonary artery radiofrequency ablation catheter |
US9254166B2 (en) | 2013-01-17 | 2016-02-09 | Arthrocare Corporation | Systems and methods for turbinate reduction |
US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
US20140276051A1 (en) * | 2013-03-13 | 2014-09-18 | Gyrus ACM, Inc. (d.b.a Olympus Surgical Technologies America) | Device for Minimally Invasive Delivery of Treatment Substance |
US9033972B2 (en) * | 2013-03-15 | 2015-05-19 | Thermedical, Inc. | Methods and devices for fluid enhanced microwave ablation therapy |
US9782211B2 (en) | 2013-10-01 | 2017-10-10 | Uptake Medical Technology Inc. | Preferential volume reduction of diseased segments of a heterogeneous lobe |
EP3116408B1 (en) | 2014-03-12 | 2018-12-19 | Cibiem, Inc. | Ultrasound ablation catheter |
US10471254B2 (en) | 2014-05-12 | 2019-11-12 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
US10485604B2 (en) | 2014-12-02 | 2019-11-26 | Uptake Medical Technology Inc. | Vapor treatment of lung nodules and tumors |
WO2016100325A1 (en) | 2014-12-15 | 2016-06-23 | Virginia Tech Intellectual Properties, Inc. | Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment |
US10531906B2 (en) | 2015-02-02 | 2020-01-14 | Uptake Medical Technology Inc. | Medical vapor generator |
EP3297703A4 (en) | 2015-05-18 | 2019-01-16 | The General Hospital Corporation | System and method for phototherapy for preventing or treating carbon monoxide poisoning |
US9743984B1 (en) | 2016-08-11 | 2017-08-29 | Thermedical, Inc. | Devices and methods for delivering fluid to tissue during ablation therapy |
US10905492B2 (en) | 2016-11-17 | 2021-02-02 | Angiodynamics, Inc. | Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode |
US11129673B2 (en) | 2017-05-05 | 2021-09-28 | Uptake Medical Technology Inc. | Extra-airway vapor ablation for treating airway constriction in patients with asthma and COPD |
US11344364B2 (en) | 2017-09-07 | 2022-05-31 | Uptake Medical Technology Inc. | Screening method for a target nerve to ablate for the treatment of inflammatory lung disease |
US11350988B2 (en) | 2017-09-11 | 2022-06-07 | Uptake Medical Technology Inc. | Bronchoscopic multimodality lung tumor treatment |
USD845467S1 (en) | 2017-09-17 | 2019-04-09 | Uptake Medical Technology Inc. | Hand-piece for medical ablation catheter |
US11419658B2 (en) | 2017-11-06 | 2022-08-23 | Uptake Medical Technology Inc. | Method for treating emphysema with condensable thermal vapor |
US11607537B2 (en) | 2017-12-05 | 2023-03-21 | Virginia Tech Intellectual Properties, Inc. | Method for treating neurological disorders, including tumors, with electroporation |
US11490946B2 (en) | 2017-12-13 | 2022-11-08 | Uptake Medical Technology Inc. | Vapor ablation handpiece |
US11311329B2 (en) | 2018-03-13 | 2022-04-26 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for immunotherapy based treatments using non-thermal ablation techniques |
US11925405B2 (en) | 2018-03-13 | 2024-03-12 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
CA3100063A1 (en) * | 2018-04-17 | 2019-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | Airway visualization system |
US11083871B2 (en) | 2018-05-03 | 2021-08-10 | Thermedical, Inc. | Selectively deployable catheter ablation devices |
US11918277B2 (en) | 2018-07-16 | 2024-03-05 | Thermedical, Inc. | Inferred maximum temperature monitoring for irrigated ablation therapy |
US11653927B2 (en) | 2019-02-18 | 2023-05-23 | Uptake Medical Technology Inc. | Vapor ablation treatment of obstructive lung disease |
US11950835B2 (en) | 2019-06-28 | 2024-04-09 | Virginia Tech Intellectual Properties, Inc. | Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy |
US11633224B2 (en) | 2020-02-10 | 2023-04-25 | Icecure Medical Ltd. | Cryogen pump |
EP4108197A1 (en) | 2021-06-24 | 2022-12-28 | Gradient Denervation Technologies | Systems for treating tissue |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4784135A (en) * | 1982-12-09 | 1988-11-15 | International Business Machines Corporation | Far ultraviolet surgical and dental procedures |
US5053033A (en) * | 1990-10-10 | 1991-10-01 | Boston Advanced Technologies, Inc. | Inhibition of restenosis by ultraviolet radiation |
US5574059A (en) * | 1995-10-27 | 1996-11-12 | Cornell Research Foundation, Inc. | Treating disorders mediated by vascular smooth muscle cell proliferation |
Family Cites Families (145)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1155169A (en) | 1914-11-28 | 1915-09-28 | John Starkweather | Surgical instrument. |
US1207479A (en) | 1915-03-05 | 1916-12-05 | Holger Bisgaard | Self-retaining gatheter. |
US2072346A (en) | 1934-10-04 | 1937-03-02 | Ward R Smith | Drainage tube |
US3568659A (en) | 1968-09-24 | 1971-03-09 | James N Karnegis | Disposable percutaneous intracardiac pump and method of pumping blood |
US3692029A (en) | 1971-05-03 | 1972-09-19 | Edwin Lloyd Adair | Retention catheter and suprapubic shunt |
US4565200A (en) | 1980-09-24 | 1986-01-21 | Cosman Eric R | Universal lesion and recording electrode system |
US4706688A (en) | 1981-05-18 | 1987-11-17 | Don Michael T Anthony | Non-invasive cardiac device |
US4612934A (en) * | 1981-06-30 | 1986-09-23 | Borkan William N | Non-invasive multiprogrammable tissue stimulator |
US4584998A (en) | 1981-09-11 | 1986-04-29 | Mallinckrodt, Inc. | Multi-purpose tracheal tube |
US4522212A (en) | 1983-11-14 | 1985-06-11 | Mansfield Scientific, Inc. | Endocardial electrode |
JPS6148350A (en) | 1984-08-15 | 1986-03-10 | オリンパス光学工業株式会社 | Medical laser apparatus |
US5019075A (en) | 1984-10-24 | 1991-05-28 | The Beth Israel Hospital | Method and apparatus for angioplasty |
US4862886A (en) | 1985-05-08 | 1989-09-05 | Summit Technology Inc. | Laser angioplasty |
US4976709A (en) | 1988-12-15 | 1990-12-11 | Sand Bruce J | Method for collagen treatment |
US4827935A (en) * | 1986-04-24 | 1989-05-09 | Purdue Research Foundation | Demand electroventilator |
US4709698A (en) | 1986-05-14 | 1987-12-01 | Thomas J. Fogarty | Heatable dilation catheter |
US5231995A (en) | 1986-11-14 | 1993-08-03 | Desai Jawahar M | Method for catheter mapping and ablation |
US4802492A (en) | 1987-03-11 | 1989-02-07 | National Jewish Center For Immunology And Respiratory Medicine | Method for determining respiratory function |
US5588432A (en) | 1988-03-21 | 1996-12-31 | Boston Scientific Corporation | Catheters for imaging, sensing electrical potentials, and ablating tissue |
US4920978A (en) | 1988-08-31 | 1990-05-01 | Triangle Research And Development Corporation | Method and apparatus for the endoscopic treatment of deep tumors using RF hyperthermia |
US5191883A (en) | 1988-10-28 | 1993-03-09 | Prutech Research And Development Partnership Ii | Device for heating tissue in a patient's body |
US4955377A (en) | 1988-10-28 | 1990-09-11 | Lennox Charles D | Device and method for heating tissue in a patient's body |
US5779698A (en) | 1989-01-18 | 1998-07-14 | Applied Medical Resources Corporation | Angioplasty catheter system and method for making same |
US5433730A (en) | 1989-05-03 | 1995-07-18 | Intermedics, Inc. | Conductive pouch electrode for defibrillation |
US5084044A (en) | 1989-07-14 | 1992-01-28 | Ciron Corporation | Apparatus for endometrial ablation and method of using same |
US5562608A (en) | 1989-08-28 | 1996-10-08 | Biopulmonics, Inc. | Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation |
CA2067110C (en) | 1989-09-08 | 2001-07-31 | John E. Abele | Physiologic low stress angioplasty |
US5100388A (en) | 1989-09-15 | 1992-03-31 | Interventional Thermodynamics, Inc. | Method and device for thermal ablation of hollow body organs |
US5117828A (en) | 1989-09-25 | 1992-06-02 | Arzco Medical Electronics, Inc. | Expandable esophageal catheter |
FR2659240B1 (en) | 1990-03-06 | 1997-07-04 | Daniel Galley | EPIDURAL ELECTRODE SYSTEM CALLED TO BE INTRODUCED INTO THE EPIDURAL SPACE. |
US5549559A (en) | 1990-03-22 | 1996-08-27 | Argomed Ltd. | Thermal treatment apparatus |
US5096916A (en) | 1990-05-07 | 1992-03-17 | Aegis Technology, Inc. | Treatment of chronic obstructive pulmonary disease (copd) by inhalation of an imidazoline |
US5056519A (en) * | 1990-05-14 | 1991-10-15 | Vince Dennis J | Unilateral diaphragmatic pacer |
US5265604A (en) * | 1990-05-14 | 1993-11-30 | Vince Dennis J | Demand - diaphragmatic pacing (skeletal muscle pressure modified) |
US5103804A (en) | 1990-07-03 | 1992-04-14 | Boston Scientific Corporation | Expandable tip hemostatic probes and the like |
US5135517A (en) | 1990-07-19 | 1992-08-04 | Catheter Research, Inc. | Expandable tube-positioning apparatus |
US5100423A (en) | 1990-08-21 | 1992-03-31 | Medical Engineering & Development Institute, Inc. | Ablation catheter |
US5170803A (en) | 1990-09-28 | 1992-12-15 | Brunswick Biomedical Technologies, Inc. | Esophageal displacement electrode |
US5174288A (en) | 1990-11-30 | 1992-12-29 | Medtronic, Inc. | Method and apparatus for cardiac defibrillation |
US5345936A (en) | 1991-02-15 | 1994-09-13 | Cardiac Pathways Corporation | Apparatus with basket assembly for endocardial mapping |
US5465717A (en) | 1991-02-15 | 1995-11-14 | Cardiac Pathways Corporation | Apparatus and Method for ventricular mapping and ablation |
US5415166A (en) | 1991-02-15 | 1995-05-16 | Cardiac Pathways Corporation | Endocardial mapping apparatus and cylindrical semiconductor device mounting structure for use therewith and method |
US5116864A (en) | 1991-04-09 | 1992-05-26 | Indiana University Foundation | Method for preventing restenosis following reconfiguration of body vessels |
WO1992020401A1 (en) | 1991-04-10 | 1992-11-26 | British Technology Group Usa, Inc. | Defibrillator and demand pacer catheter and method |
US5255678A (en) | 1991-06-21 | 1993-10-26 | Ecole Polytechnique | Mapping electrode balloon |
US5383917A (en) | 1991-07-05 | 1995-01-24 | Jawahar M. Desai | Device and method for multi-phase radio-frequency ablation |
US6053172A (en) * | 1995-06-07 | 2000-04-25 | Arthrocare Corporation | Systems and methods for electrosurgical sinus surgery |
US5443470A (en) | 1992-05-01 | 1995-08-22 | Vesta Medical, Inc. | Method and apparatus for endometrial ablation |
US5255679A (en) | 1992-06-02 | 1993-10-26 | Cardiac Pathways Corporation | Endocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method |
US5281218A (en) | 1992-06-05 | 1994-01-25 | Cardiac Pathways Corporation | Catheter having needle electrode for radiofrequency ablation |
US5324284A (en) | 1992-06-05 | 1994-06-28 | Cardiac Pathways, Inc. | Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method |
US5782239A (en) | 1992-06-30 | 1998-07-21 | Cordis Webster, Inc. | Unique electrode configurations for cardiovascular electrode catheter with built-in deflection method and central puller wire |
US5772590A (en) | 1992-06-30 | 1998-06-30 | Cordis Webster, Inc. | Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire |
US5411025A (en) | 1992-06-30 | 1995-05-02 | Cordis Webster, Inc. | Cardiovascular catheter with laterally stable basket-shaped electrode array |
GB9219102D0 (en) * | 1992-09-09 | 1992-10-21 | Fairfax Andrew J | Flowmeters |
US5309910A (en) | 1992-09-25 | 1994-05-10 | Ep Technologies, Inc. | Cardiac mapping and ablation systems |
US5313943A (en) | 1992-09-25 | 1994-05-24 | Ep Technologies, Inc. | Catheters and methods for performing cardiac diagnosis and treatment |
US5293869A (en) | 1992-09-25 | 1994-03-15 | Ep Technologies, Inc. | Cardiac probe with dynamic support for maintaining constant surface contact during heart systole and diastole |
US5471982A (en) | 1992-09-29 | 1995-12-05 | Ep Technologies, Inc. | Cardiac mapping and ablation systems |
DE69315704T3 (en) | 1992-10-01 | 2002-08-01 | Cardiac Pacemakers Inc | STENT-LIKE STRUCTURE FOR DEFLICTION ELECTRODES |
US5431696A (en) | 1992-10-13 | 1995-07-11 | Atlee, Iii; John L. | Esophageal probe for transeophageal cardiac stimulation |
US5807306A (en) | 1992-11-09 | 1998-09-15 | Cortrak Medical, Inc. | Polymer matrix drug delivery apparatus |
US5348554A (en) | 1992-12-01 | 1994-09-20 | Cardiac Pathways Corporation | Catheter for RF ablation with cooled electrode |
US5545161A (en) | 1992-12-01 | 1996-08-13 | Cardiac Pathways Corporation | Catheter for RF ablation having cooled electrode with electrically insulated sleeve |
US5256141A (en) | 1992-12-22 | 1993-10-26 | Nelson Gencheff | Biological material deployment method and apparatus |
US5417687A (en) | 1993-04-30 | 1995-05-23 | Medical Scientific, Inc. | Bipolar electrosurgical trocar |
US5456667A (en) | 1993-05-20 | 1995-10-10 | Advanced Cardiovascular Systems, Inc. | Temporary stenting catheter with one-piece expandable segment |
US5860974A (en) | 1993-07-01 | 1999-01-19 | Boston Scientific Corporation | Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft |
DE69432148T2 (en) | 1993-07-01 | 2003-10-16 | Boston Scient Ltd | CATHETER FOR IMAGE DISPLAY, DISPLAY OF ELECTRICAL SIGNALS AND ABLATION |
US5396887A (en) | 1993-09-23 | 1995-03-14 | Cardiac Pathways Corporation | Apparatus and method for detecting contact pressure |
US5626618A (en) | 1993-09-24 | 1997-05-06 | The Ohio State University | Mechanical adjunct to cardiopulmonary resuscitation (CPR), and an electrical adjunct to defibrillation countershock, cardiac pacing, and cardiac monitoring |
US5607462A (en) | 1993-09-24 | 1997-03-04 | Cardiac Pathways Corporation | Catheter assembly, catheter and multi-catheter introducer for use therewith |
US5908446A (en) | 1994-07-07 | 1999-06-01 | Cardiac Pathways Corporation | Catheter assembly, catheter and multi-port introducer for use therewith |
US5415656A (en) | 1993-09-28 | 1995-05-16 | American Medical Systems, Inc. | Electrosurgical apparatus |
US5400783A (en) | 1993-10-12 | 1995-03-28 | Cardiac Pathways Corporation | Endocardial mapping apparatus with rotatable arm and method |
US5881727A (en) | 1993-10-14 | 1999-03-16 | Ep Technologies, Inc. | Integrated cardiac mapping and ablation probe |
US5991650A (en) | 1993-10-15 | 1999-11-23 | Ep Technologies, Inc. | Surface coatings for catheters, direct contacting diagnostic and therapeutic devices |
US5545193A (en) | 1993-10-15 | 1996-08-13 | Ep Technologies, Inc. | Helically wound radio-frequency emitting electrodes for creating lesions in body tissue |
US5423812A (en) * | 1994-01-31 | 1995-06-13 | Ellman; Alan G. | Electrosurgical stripping electrode for palatopharynx tissue |
US5394880A (en) | 1994-03-17 | 1995-03-07 | Atlee, Iii; John L. | Esophageal stethoscope |
US5598848A (en) | 1994-03-31 | 1997-02-04 | Ep Technologies, Inc. | Systems and methods for positioning multiple electrode structures in electrical contact with the myocardium |
US5458596A (en) | 1994-05-06 | 1995-10-17 | Dorsal Orthopedic Corporation | Method and apparatus for controlled contraction of soft tissue |
US5681308A (en) | 1994-06-24 | 1997-10-28 | Stuart D. Edwards | Ablation apparatus for cardiac chambers |
US6009877A (en) | 1994-06-24 | 2000-01-04 | Edwards; Stuart D. | Method for treating a sphincter |
US5827277A (en) | 1994-06-24 | 1998-10-27 | Somnus Medical Technologies, Inc. | Minimally invasive apparatus for internal ablation of turbinates |
US6056744A (en) | 1994-06-24 | 2000-05-02 | Conway Stuart Medical, Inc. | Sphincter treatment apparatus |
US5680860A (en) | 1994-07-07 | 1997-10-28 | Cardiac Pathways Corporation | Mapping and/or ablation catheter with coilable distal extremity and method for using same |
US5454782A (en) | 1994-08-11 | 1995-10-03 | Perkins; Rodney C. | Translumenal circumferential energy delivery device |
US5522862A (en) | 1994-09-21 | 1996-06-04 | Medtronic, Inc. | Method and apparatus for treating obstructive sleep apnea |
US5549655A (en) * | 1994-09-21 | 1996-08-27 | Medtronic, Inc. | Method and apparatus for synchronized treatment of obstructive sleep apnea |
US5836947A (en) | 1994-10-07 | 1998-11-17 | Ep Technologies, Inc. | Flexible structures having movable splines for supporting electrode elements |
US5740808A (en) | 1996-10-28 | 1998-04-21 | Ep Technologies, Inc | Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions |
US5722401A (en) | 1994-10-19 | 1998-03-03 | Cardiac Pathways Corporation | Endocardial mapping and/or ablation catheter probe |
US5605157A (en) | 1995-02-17 | 1997-02-25 | Ep Technologies, Inc. | Systems and methods for filtering signals derived from biological events |
US5630425A (en) | 1995-02-17 | 1997-05-20 | Ep Technologies, Inc. | Systems and methods for adaptive filtering artifacts from composite signals |
US5601088A (en) | 1995-02-17 | 1997-02-11 | Ep Technologies, Inc. | Systems and methods for filtering artifacts from composite signals |
JP3681126B2 (en) | 1995-02-17 | 2005-08-10 | ボストン サイエンティフィック リミテッド | System for time-series measurement of biological events |
US5792064A (en) | 1995-02-17 | 1998-08-11 | Panescu; Dorin | Systems and methods for analyzing cardiac biopotential morphologies by cross-correlation |
US5595183A (en) | 1995-02-17 | 1997-01-21 | Ep Technologies, Inc. | Systems and methods for examining heart tissue employing multiple electrode structures and roving electrodes |
US5711305A (en) | 1995-02-17 | 1998-01-27 | Ep Technologies, Inc. | Systems and methods for acquiring endocardially or epicardially paced electrocardiograms |
US5722416A (en) | 1995-02-17 | 1998-03-03 | Ep Technologies, Inc. | Systems and methods for analyzing biopotential morphologies in heart tissue to locate potential ablation sites |
US5868740A (en) | 1995-03-24 | 1999-02-09 | Board Of Regents-Univ Of Nebraska | Method for volumetric tissue ablation |
US5620438A (en) | 1995-04-20 | 1997-04-15 | Angiomedics Ii Incorporated | Method and apparatus for treating vascular tissue following angioplasty to minimize restenosis |
US5678535A (en) * | 1995-04-21 | 1997-10-21 | Dimarco; Anthony Fortunato | Method and apparatus for electrical stimulation of the respiratory muscles to achieve artificial ventilation in a patient |
US5607419A (en) | 1995-04-24 | 1997-03-04 | Angiomedics Ii Inc. | Method and apparatus for treating vessel wall with UV radiation following angioplasty |
US5755753A (en) | 1995-05-05 | 1998-05-26 | Thermage, Inc. | Method for controlled contraction of collagen tissue |
US6132438A (en) | 1995-06-07 | 2000-10-17 | Ep Technologies, Inc. | Devices for installing stasis reducing means in body tissue |
US5697925A (en) | 1995-06-09 | 1997-12-16 | Engineering & Research Associates, Inc. | Apparatus and method for thermal ablation |
JPH0947518A (en) * | 1995-06-26 | 1997-02-18 | Lederle Japan Ltd | Optical fiber laser probe for photodynamic therapy |
WO1997004702A1 (en) | 1995-07-28 | 1997-02-13 | Ep Technologies, Inc. | Systems and methods for conducting electrophysiological testing using high-voltage energy pulses to stun heart tissue |
US5624439A (en) * | 1995-08-18 | 1997-04-29 | Somnus Medical Technologies, Inc. | Method and apparatus for treatment of air way obstructions |
US5848972A (en) | 1995-09-15 | 1998-12-15 | Children's Medical Center Corporation | Method for endocardial activation mapping using a multi-electrode catheter |
US5846238A (en) | 1996-01-19 | 1998-12-08 | Ep Technologies, Inc. | Expandable-collapsible electrode structures with distal end steering or manipulation |
US5891136A (en) | 1996-01-19 | 1999-04-06 | Ep Technologies, Inc. | Expandable-collapsible mesh electrode structures |
US5904711A (en) | 1996-02-08 | 1999-05-18 | Heartport, Inc. | Expandable thoracoscopic defibrillation catheter system and method |
US5730726A (en) | 1996-03-04 | 1998-03-24 | Klingenstein; Ralph James | Apparatus and method for removing fecal impaction |
US6036687A (en) | 1996-03-05 | 2000-03-14 | Vnus Medical Technologies, Inc. | Method and apparatus for treating venous insufficiency |
JPH09243837A (en) * | 1996-03-14 | 1997-09-19 | Hitachi Cable Ltd | Laser waveguide |
US5699799A (en) * | 1996-03-26 | 1997-12-23 | Siemens Corporate Research, Inc. | Automatic determination of the curved axis of a 3-D tube-shaped object in image volume |
US5863291A (en) | 1996-04-08 | 1999-01-26 | Cardima, Inc. | Linear ablation assembly |
US5979456A (en) * | 1996-04-22 | 1999-11-09 | Magovern; George J. | Apparatus and method for reversibly reshaping a body part |
US5810807A (en) | 1996-05-22 | 1998-09-22 | Ganz; Robert A. | Sphincterotome with deflectable cutting plane and method of using the same |
JPH1026709A (en) * | 1996-07-11 | 1998-01-27 | Harufumi Kato | Device for laterally irradiating with laser beam |
US5882346A (en) | 1996-07-15 | 1999-03-16 | Cardiac Pathways Corporation | Shapable catheter using exchangeable core and method of use |
US5855577A (en) | 1996-09-17 | 1999-01-05 | Eclipse Surgical Technologies, Inc. | Bow shaped catheter |
US5904651A (en) | 1996-10-28 | 1999-05-18 | Ep Technologies, Inc. | Systems and methods for visualizing tissue during diagnostic or therapeutic procedures |
US5722403A (en) | 1996-10-28 | 1998-03-03 | Ep Technologies, Inc. | Systems and methods using a porous electrode for ablating and visualizing interior tissue regions |
US5848969A (en) | 1996-10-28 | 1998-12-15 | Ep Technologies, Inc. | Systems and methods for visualizing interior tissue regions using expandable imaging structures |
US5752518A (en) | 1996-10-28 | 1998-05-19 | Ep Technologies, Inc. | Systems and methods for visualizing interior regions of the body |
JPH10127789A (en) * | 1996-10-28 | 1998-05-19 | Hamamatsu Photonics Kk | Light beam processing device |
US5908445A (en) | 1996-10-28 | 1999-06-01 | Ep Technologies, Inc. | Systems for visualizing interior tissue regions including an actuator to move imaging element |
US5730741A (en) | 1997-02-07 | 1998-03-24 | Eclipse Surgical Technologies, Inc. | Guided spiral catheter |
US5873865A (en) | 1997-02-07 | 1999-02-23 | Eclipse Surgical Technologies, Inc. | Spiral catheter with multiple guide holes |
US5882329A (en) | 1997-02-12 | 1999-03-16 | Prolifix Medical, Inc. | Apparatus and method for removing stenotic material from stents |
US5999855A (en) | 1997-02-28 | 1999-12-07 | Dimarco; Anthony F. | Method and apparatus for electrical activation of the expiratory muscles to restore cough |
US5897554A (en) | 1997-03-01 | 1999-04-27 | Irvine Biomedical, Inc. | Steerable catheter having a loop electrode |
US5954661A (en) | 1997-03-31 | 1999-09-21 | Thomas Jefferson University | Tissue characterization and treatment using pacing |
US5972026A (en) * | 1997-04-07 | 1999-10-26 | Broncus Technologies, Inc. | Bronchial stenter having diametrically adjustable electrodes |
US6083255A (en) | 1997-04-07 | 2000-07-04 | Broncus Technologies, Inc. | Bronchial stenter |
US6200333B1 (en) | 1997-04-07 | 2001-03-13 | Broncus Technologies, Inc. | Bronchial stenter |
US5971983A (en) | 1997-05-09 | 1999-10-26 | The Regents Of The University Of California | Tissue ablation device and method of use |
US6024740A (en) | 1997-07-08 | 2000-02-15 | The Regents Of The University Of California | Circumferential ablation device assembly |
US5893835A (en) | 1997-10-10 | 1999-04-13 | Ethicon Endo-Surgery, Inc. | Ultrasonic clamp coagulator apparatus having dual rotational positioning |
US6142993A (en) | 1998-02-27 | 2000-11-07 | Ep Technologies, Inc. | Collapsible spline structure using a balloon as an expanding actuator |
US5992419A (en) | 1998-08-20 | 1999-11-30 | Mmtc, Inc. | Method employing a tissue-heating balloon catheter to produce a "biological stent" in an orifice or vessel of a patient's body |
-
1999
- 1999-04-21 US US09/296,040 patent/US6411852B1/en not_active Expired - Lifetime
- 1999-06-09 WO PCT/US1999/012986 patent/WO1999064109A1/en active Application Filing
- 1999-06-09 AU AU44304/99A patent/AU4430499A/en not_active Abandoned
- 1999-06-09 JP JP2000553172A patent/JP2002517295A/en active Pending
-
2004
- 2004-03-26 US US10/810,276 patent/US20050010270A1/en not_active Abandoned
-
2008
- 2008-08-12 JP JP2008208277A patent/JP2009000545A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4784135A (en) * | 1982-12-09 | 1988-11-15 | International Business Machines Corporation | Far ultraviolet surgical and dental procedures |
US5053033A (en) * | 1990-10-10 | 1991-10-01 | Boston Advanced Technologies, Inc. | Inhibition of restenosis by ultraviolet radiation |
US5574059A (en) * | 1995-10-27 | 1996-11-12 | Cornell Research Foundation, Inc. | Treating disorders mediated by vascular smooth muscle cell proliferation |
Cited By (167)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8944071B2 (en) | 1997-04-07 | 2015-02-03 | Asthmatx, Inc. | Method for treating an asthma attack |
US7740017B2 (en) | 1997-04-07 | 2010-06-22 | Asthmatx, Inc. | Method for treating an asthma attack |
US20050187579A1 (en) * | 1997-04-07 | 2005-08-25 | Asthmatx, Inc. | Method for treating an asthma attack |
US8267094B2 (en) | 1997-04-07 | 2012-09-18 | Asthmatx, Inc. | Modification of airways by application of ultrasound energy |
US20030159700A1 (en) * | 1997-04-07 | 2003-08-28 | Laufer Michael D. | Method of increasing gas exchange of a lung |
US20090143705A1 (en) * | 1997-04-07 | 2009-06-04 | Asthmatx, Inc. | Modification of airways by application of ultrasound energy |
US8161978B2 (en) | 1997-04-07 | 2012-04-24 | Asthmatx, Inc. | Methods for treating asthma by damaging nerve tissue |
US9956023B2 (en) | 1997-04-07 | 2018-05-01 | Boston Scientific Scimed, Inc. | System for treating a lung |
US20100185190A1 (en) * | 1997-04-07 | 2010-07-22 | Asthmatx, Inc. | Methods for treating asthma damaging nerve tissue |
US8640711B2 (en) | 1997-04-07 | 2014-02-04 | Asthmatx, Inc. | Method for treating an asthma attack |
US10058370B2 (en) | 1997-04-07 | 2018-08-28 | Boston Scientific Scimed, Inc. | Method for treating a lung |
US7770584B2 (en) | 1997-04-07 | 2010-08-10 | Asthmatx, Inc. | Modification of airways by application of microwave energy |
US9027564B2 (en) | 1997-04-07 | 2015-05-12 | Asthmatx, Inc. | Method for treating a lung |
US11033317B2 (en) | 1997-04-07 | 2021-06-15 | Boston Scientific Scimed, Inc. | Methods for treating a lung |
US20070106296A1 (en) * | 1997-04-07 | 2007-05-10 | Asthmatx, Inc. | Expandable electode devices and methods of treating bronchial tubes |
US7938123B2 (en) | 1997-04-07 | 2011-05-10 | Asthmatx, Inc. | Modification of airways by application of cryo energy |
US7921855B2 (en) | 1998-01-07 | 2011-04-12 | Asthmatx, Inc. | Method for treating an asthma attack |
US20070083197A1 (en) * | 1998-01-07 | 2007-04-12 | Asthmatx, Inc. | Method for treating an asthma attack |
US8584681B2 (en) | 1998-01-07 | 2013-11-19 | Asthmatx, Inc. | Method for treating an asthma attack |
US20100204689A1 (en) * | 1998-01-07 | 2010-08-12 | Asthmatx, Inc. | Method for treating an asthma attack |
US9789331B2 (en) | 1998-01-07 | 2017-10-17 | Boston Scientific Scimed, Inc. | Methods of treating a lung |
US7992572B2 (en) | 1998-06-10 | 2011-08-09 | Asthmatx, Inc. | Methods of evaluating individuals having reversible obstructive pulmonary disease |
US20070102011A1 (en) * | 1998-06-10 | 2007-05-10 | Asthmatx, Inc. | Methods of evaluating individuals having reversible obstructive pulmonary disease |
US20070118184A1 (en) * | 1998-06-10 | 2007-05-24 | Asthmatx, Inc. | Devices for modification of airways by transfer of energy |
US8443810B2 (en) | 1998-06-10 | 2013-05-21 | Asthmatx, Inc. | Methods of reducing mucus in airways |
US20070123958A1 (en) * | 1998-06-10 | 2007-05-31 | Asthmatx, Inc. | Apparatus for treating airways in the lung |
US20070062545A1 (en) * | 1998-06-10 | 2007-03-22 | Asthmatx, Inc. | Methods of regenerating tissue in airways |
US8733367B2 (en) | 1998-06-10 | 2014-05-27 | Asthmatx, Inc. | Methods of treating inflammation in airways |
US20070118190A1 (en) * | 1998-06-10 | 2007-05-24 | Asthmatx, Inc. | Methods of treating asthma |
US8534291B2 (en) | 1998-06-10 | 2013-09-17 | Asthmatx, Inc. | Methods of treating inflammation in airways |
US8181656B2 (en) | 1998-06-10 | 2012-05-22 | Asthmatx, Inc. | Methods for treating airways |
US8464723B2 (en) | 1998-06-10 | 2013-06-18 | Asthmatx, Inc. | Methods of evaluating individuals having reversible obstructive pulmonary disease |
US20040031494A1 (en) * | 1998-06-10 | 2004-02-19 | Broncus Technologies, Inc. | Methods of treating asthma |
US7947033B2 (en) | 1999-04-06 | 2011-05-24 | Kci Licensing Inc. | Systems and methods for detection of wound fluid blood and application of phototherapy in conjunction with reduced pressure wound treatment system |
US6994702B1 (en) * | 1999-04-06 | 2006-02-07 | Kci Licensing, Inc. | Vacuum assisted closure pad with adaptation for phototherapy |
US20060173253A1 (en) * | 1999-04-06 | 2006-08-03 | Kci Licensing, Inc. | Systems and methods for detection of wound fluid blood and application of phototherapy in conjunction with reduced pressure wound treatment system |
US9326683B2 (en) | 1999-04-06 | 2016-05-03 | Kci Licensing, Inc. | Systems and methods for detection of wound fluid blood and application of phototherapy in conjunction with reduced pressure wound treatment system |
US10278766B2 (en) | 2000-03-27 | 2019-05-07 | Boston Scientific Scimed, Inc. | Methods for treating airways |
US8251070B2 (en) | 2000-03-27 | 2012-08-28 | Asthmatx, Inc. | Methods for treating airways |
US10561458B2 (en) | 2000-03-27 | 2020-02-18 | Boston Scientific Scimed, Inc. | Methods for treating airways |
US9358024B2 (en) | 2000-03-27 | 2016-06-07 | Asthmatx, Inc. | Methods for treating airways |
US8459268B2 (en) | 2000-03-27 | 2013-06-11 | Asthmatx, Inc. | Methods for treating airways |
US7837679B2 (en) | 2000-10-17 | 2010-11-23 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
US8257413B2 (en) | 2000-10-17 | 2012-09-04 | Asthmatx, Inc. | Modification of airways by application of energy |
US8888769B2 (en) | 2000-10-17 | 2014-11-18 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
US20060247726A1 (en) * | 2000-10-17 | 2006-11-02 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
US8465486B2 (en) | 2000-10-17 | 2013-06-18 | Asthmatx, Inc. | Modification of airways by application of energy |
US7854734B2 (en) | 2000-10-17 | 2010-12-21 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
US9033976B2 (en) | 2000-10-17 | 2015-05-19 | Asthmatx, Inc. | Modification of airways by application of energy |
US9931163B2 (en) | 2000-10-17 | 2018-04-03 | Boston Scientific Scimed, Inc. | Energy delivery devices |
US10016592B2 (en) | 2001-10-17 | 2018-07-10 | Boston Scientific Scimed, Inc. | Control system and process for application of energy to airway walls and other mediums |
US9707034B2 (en) | 2002-07-01 | 2017-07-18 | Recor Medical, Inc. | Intraluminal method and apparatus for ablating nerve tissue |
US9700372B2 (en) | 2002-07-01 | 2017-07-11 | Recor Medical, Inc. | Intraluminal methods of ablating nerve tissue |
US9339618B2 (en) | 2003-05-13 | 2016-05-17 | Holaira, Inc. | Method and apparatus for controlling narrowing of at least one airway |
US8172827B2 (en) | 2003-05-13 | 2012-05-08 | Innovative Pulmonary Solutions, Inc. | Apparatus for treating asthma using neurotoxin |
US10953170B2 (en) | 2003-05-13 | 2021-03-23 | Nuvaira, Inc. | Apparatus for treating asthma using neurotoxin |
US20060222667A1 (en) * | 2003-05-13 | 2006-10-05 | The Foundry, Inc. | Apparatus for treating asthma using neurotoxin |
US7906124B2 (en) | 2004-09-18 | 2011-03-15 | Asthmatx, Inc. | Inactivation of smooth muscle tissue |
US20060062808A1 (en) * | 2004-09-18 | 2006-03-23 | Asthmatx, Inc. | Inactivation of smooth muscle tissue |
US20110184330A1 (en) * | 2004-09-18 | 2011-07-28 | Asthmatx, Inc. | Inactivation of smooth muscle tissue |
US8828945B2 (en) | 2004-09-18 | 2014-09-09 | Asthmatx, Inc. | Inactivation of smooth muscle tissue |
US10076380B2 (en) | 2004-11-05 | 2018-09-18 | Boston Scientific Scimed, Inc. | Energy delivery devices and methods |
US10398502B2 (en) | 2004-11-05 | 2019-09-03 | Boston Scientific Scimed, Inc. | Energy delivery devices and methods |
US20070106292A1 (en) * | 2004-11-05 | 2007-05-10 | Asthmatx, Inc. | Energy delivery devices and methods |
US20060247618A1 (en) * | 2004-11-05 | 2006-11-02 | Asthmatx, Inc. | Medical device with procedure improvement features |
US7949407B2 (en) | 2004-11-05 | 2011-05-24 | Asthmatx, Inc. | Energy delivery devices and methods |
US7853331B2 (en) | 2004-11-05 | 2010-12-14 | Asthmatx, Inc. | Medical device with procedure improvement features |
US8480667B2 (en) | 2004-11-05 | 2013-07-09 | Asthmatx, Inc. | Medical device with procedure improvement features |
US20060247617A1 (en) * | 2004-11-12 | 2006-11-02 | Asthmatx, Inc. | Energy delivery devices and methods |
US20070123961A1 (en) * | 2004-11-12 | 2007-05-31 | Asthmax, Inc. | Energy delivery and illumination devices and methods |
US8920413B2 (en) | 2004-11-12 | 2014-12-30 | Asthmatx, Inc. | Energy delivery devices and methods |
EP2902069A1 (en) | 2004-11-12 | 2015-08-05 | Asthmatx, Inc. | Improved energy delivery devices and methods |
US20070265639A1 (en) * | 2005-04-21 | 2007-11-15 | Asthmatx, Inc. | Devices and methods for tracking an energy delivery device which treats asthma |
US20060247683A1 (en) * | 2005-04-21 | 2006-11-02 | Asthmatx, Inc. | Control systems for delivering energy |
US9808312B2 (en) | 2005-04-21 | 2017-11-07 | Boston Scientific Scimed, Inc. | Devices and methods for tracking an energy delivery device |
US9199091B2 (en) | 2005-04-21 | 2015-12-01 | Asthmatx, Inc. | Devices and methods for tracking an energy device |
US7594925B2 (en) | 2005-04-21 | 2009-09-29 | Asthmatx, Inc. | Control systems for delivering energy |
US7708768B2 (en) | 2005-04-21 | 2010-05-04 | Asthmatx, Inc. | Devices and methods for tracking an energy delivery device which treats asthma |
US7747324B2 (en) | 2005-11-10 | 2010-06-29 | Electrocore Llc | Electrical stimulation treatment of bronchial constriction |
US20090187231A1 (en) * | 2005-11-10 | 2009-07-23 | Electrocore, Inc. | Electrical Treatment Of Bronchial Constriction |
US8840537B2 (en) | 2005-11-10 | 2014-09-23 | ElectroCore, LLC | Non-invasive treatment of bronchial constriction |
US20070106339A1 (en) * | 2005-11-10 | 2007-05-10 | Electrocore, Inc. | Electrical stimulation treatment of bronchial constriction |
US8812112B2 (en) | 2005-11-10 | 2014-08-19 | ElectroCore, LLC | Electrical treatment of bronchial constriction |
US20100042178A9 (en) * | 2005-11-10 | 2010-02-18 | Electrocore, Inc. | Electrical stimulation treatment of bronchial constriction |
US20090281593A9 (en) * | 2005-11-10 | 2009-11-12 | Electrocore, Inc. | Electrical Treatment Of Bronchial Constriction |
US9037247B2 (en) | 2005-11-10 | 2015-05-19 | ElectroCore, LLC | Non-invasive treatment of bronchial constriction |
US8612004B2 (en) | 2006-02-10 | 2013-12-17 | ElectroCore, LLC | Electrical stimulation treatment of hypotension |
US8010197B2 (en) | 2006-02-10 | 2011-08-30 | Electrocore Llc | Methods and apparatus for treating anaphylaxis using electrical modulation |
US8099167B1 (en) | 2006-02-10 | 2012-01-17 | Electrocore Llc | Methods and apparatus for treating anaphylaxis using electrical modulation |
US20070191902A1 (en) * | 2006-02-10 | 2007-08-16 | Electrocore, Inc. | Methods and apparatus for treating anaphylaxis using electrical modulation |
US8041428B2 (en) | 2006-02-10 | 2011-10-18 | Electrocore Llc | Electrical stimulation treatment of hypotension |
US8204598B2 (en) | 2006-02-10 | 2012-06-19 | Electrocore Llc | Methods and apparatus for treating bronchial restriction using electrical modulation |
US8483835B2 (en) | 2006-02-10 | 2013-07-09 | ElectroCore, LLC | Methods and apparatus for treating anaphylaxis using electrical modulation |
US8233988B2 (en) | 2006-02-10 | 2012-07-31 | Electrocore Llc | Electrical stimulation treatment of hypotension |
US7869879B2 (en) | 2006-02-10 | 2011-01-11 | Electrocore Llc | Electrical stimulation treatment of hypotension |
US7711430B2 (en) | 2006-02-10 | 2010-05-04 | Electrocore Llc | Methods and apparatus for treating anaphylaxis using electrical modulation |
US20070191905A1 (en) * | 2006-02-10 | 2007-08-16 | Electrocore, Inc. | Electrical stimulation treatment of hypotension |
US20100114261A1 (en) * | 2006-02-10 | 2010-05-06 | Electrocore Llc | Electrical Stimulation Treatment of Hypotension |
US7725188B2 (en) | 2006-02-10 | 2010-05-25 | Electrocore Llc | Electrical stimulation treatment of hypotension |
US20100057178A1 (en) * | 2006-04-18 | 2010-03-04 | Electrocore, Inc. | Methods and apparatus for spinal cord stimulation using expandable electrode |
US20080183237A1 (en) * | 2006-04-18 | 2008-07-31 | Electrocore, Inc. | Methods And Apparatus For Treating Ileus Condition Using Electrical Signals |
WO2008051706A2 (en) | 2006-10-20 | 2008-05-02 | Asthmatx, Inc. | Electrode markers and methods of use |
US7931647B2 (en) | 2006-10-20 | 2011-04-26 | Asthmatx, Inc. | Method of delivering energy to a lung airway using markers |
US20110166565A1 (en) * | 2006-10-20 | 2011-07-07 | Asthmatx, Inc. | Method of delivering energy to a lung airway using markers |
US20080097424A1 (en) * | 2006-10-20 | 2008-04-24 | Asthmatx, Inc. | Electrode markers and methods of use |
US10368941B2 (en) | 2007-07-12 | 2019-08-06 | Boston Scientific Scimed, Inc. | Systems and methods for delivering energy to passageways in a patient |
US11478299B2 (en) | 2007-07-12 | 2022-10-25 | Boston Scientific Scimed, Inc. | Systems and methods for delivering energy to passageways in a patient |
US8235983B2 (en) | 2007-07-12 | 2012-08-07 | Asthmatx, Inc. | Systems and methods for delivering energy to passageways in a patient |
US20090018538A1 (en) * | 2007-07-12 | 2009-01-15 | Asthmatx, Inc. | Systems and methods for delivering energy to passageways in a patient |
EP2653127A1 (en) | 2007-07-12 | 2013-10-23 | Asthmatx, Inc. | Systems and methods for delivering energy to passageways in a patient |
US11534229B2 (en) | 2007-07-24 | 2022-12-27 | Boston Scientific Scimed, Inc. | System and method for controlling power based on impedance detection, such as controlling power to tissue treatment devices |
US20090030477A1 (en) * | 2007-07-24 | 2009-01-29 | Asthmatx, Inc. | System and method for controlling power based on impedance detection, such as controlling power to tissue treatment devices |
US10278765B2 (en) | 2007-07-24 | 2019-05-07 | Boston Scientific Scimed, Inc. | System and method for controlling power based on impedance detection, such as controlling power to tissue treatment devices |
US9108052B2 (en) | 2007-07-24 | 2015-08-18 | Asthmatx, Inc. | System and method for controlling power based on impedance detection, such as controlling power to tissue treatment devices |
US20090043301A1 (en) * | 2007-08-09 | 2009-02-12 | Asthmatx, Inc. | Monopolar energy delivery devices and methods for controlling current density in tissue |
US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
US9125643B2 (en) | 2008-02-15 | 2015-09-08 | Holaira, Inc. | System and method for bronchial dilation |
US11058879B2 (en) | 2008-02-15 | 2021-07-13 | Nuvaira, Inc. | System and method for bronchial dilation |
US8731672B2 (en) | 2008-02-15 | 2014-05-20 | Holaira, Inc. | System and method for bronchial dilation |
US8489192B1 (en) | 2008-02-15 | 2013-07-16 | Holaira, Inc. | System and method for bronchial dilation |
US10149714B2 (en) | 2008-05-09 | 2018-12-11 | Nuvaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8088127B2 (en) | 2008-05-09 | 2012-01-03 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8808280B2 (en) | 2008-05-09 | 2014-08-19 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8226638B2 (en) | 2008-05-09 | 2012-07-24 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8961507B2 (en) | 2008-05-09 | 2015-02-24 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8961508B2 (en) | 2008-05-09 | 2015-02-24 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US20090306644A1 (en) * | 2008-05-09 | 2009-12-10 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8821489B2 (en) | 2008-05-09 | 2014-09-02 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US11937868B2 (en) | 2008-05-09 | 2024-03-26 | Nuvaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US9668809B2 (en) | 2008-05-09 | 2017-06-06 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8974445B2 (en) | 2009-01-09 | 2015-03-10 | Recor Medical, Inc. | Methods and apparatus for treatment of cardiac valve insufficiency |
US20100179424A1 (en) * | 2009-01-09 | 2010-07-15 | Reinhard Warnking | Methods and apparatus for treatment of mitral valve insufficiency |
US20110125203A1 (en) * | 2009-03-20 | 2011-05-26 | ElectroCore, LLC. | Magnetic Stimulation Devices and Methods of Therapy |
US20100241188A1 (en) * | 2009-03-20 | 2010-09-23 | Electrocore, Inc. | Percutaneous Electrical Treatment Of Tissue |
US9931162B2 (en) | 2009-10-27 | 2018-04-03 | Nuvaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US20110152855A1 (en) * | 2009-10-27 | 2011-06-23 | Mayse Martin L | Delivery devices with coolable energy emitting assemblies |
US8740895B2 (en) | 2009-10-27 | 2014-06-03 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US9675412B2 (en) | 2009-10-27 | 2017-06-13 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US9649153B2 (en) | 2009-10-27 | 2017-05-16 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US8932289B2 (en) | 2009-10-27 | 2015-01-13 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US9005195B2 (en) | 2009-10-27 | 2015-04-14 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US9017324B2 (en) | 2009-10-27 | 2015-04-28 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US8777943B2 (en) | 2009-10-27 | 2014-07-15 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US11712283B2 (en) | 2009-11-11 | 2023-08-01 | Nuvaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US9149328B2 (en) | 2009-11-11 | 2015-10-06 | Holaira, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US11389233B2 (en) | 2009-11-11 | 2022-07-19 | Nuvaira, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
US9649154B2 (en) | 2009-11-11 | 2017-05-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US20110118725A1 (en) * | 2009-11-11 | 2011-05-19 | Mayse Martin L | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US10610283B2 (en) | 2009-11-11 | 2020-04-07 | Nuvaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US9950188B2 (en) | 2012-05-31 | 2018-04-24 | Color Seven Co., Ltd. | Apparatus for relaxing smooth muscles of human body |
US10881873B2 (en) | 2012-05-31 | 2021-01-05 | Color Seven Co., Ltd | Apparatus for relaxing smooth muscles of human body |
US9770293B2 (en) | 2012-06-04 | 2017-09-26 | Boston Scientific Scimed, Inc. | Systems and methods for treating tissue of a passageway within a body |
US9592086B2 (en) | 2012-07-24 | 2017-03-14 | Boston Scientific Scimed, Inc. | Electrodes for tissue treatment |
US9272132B2 (en) | 2012-11-02 | 2016-03-01 | Boston Scientific Scimed, Inc. | Medical device for treating airways and related methods of use |
US9572619B2 (en) | 2012-11-02 | 2017-02-21 | Boston Scientific Scimed, Inc. | Medical device for treating airways and related methods of use |
WO2014071372A1 (en) | 2012-11-05 | 2014-05-08 | Boston Scientific Scimed, Inc. | Devices for delivering energy to body lumens |
US9974609B2 (en) | 2012-11-05 | 2018-05-22 | Boston Scientific Scimed, Inc. | Devices and methods for delivering energy to body lumens |
US10492859B2 (en) | 2012-11-05 | 2019-12-03 | Boston Scientific Scimed, Inc. | Devices and methods for delivering energy to body lumens |
US9283374B2 (en) | 2012-11-05 | 2016-03-15 | Boston Scientific Scimed, Inc. | Devices and methods for delivering energy to body lumens |
US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
US9814618B2 (en) | 2013-06-06 | 2017-11-14 | Boston Scientific Scimed, Inc. | Devices for delivering energy and related methods of use |
US10478247B2 (en) | 2013-08-09 | 2019-11-19 | Boston Scientific Scimed, Inc. | Expandable catheter and related methods of manufacture and use |
US11801090B2 (en) | 2013-08-09 | 2023-10-31 | Boston Scientific Scimed, Inc. | Expandable catheter and related methods of manufacture and use |
US11369433B2 (en) | 2016-06-27 | 2022-06-28 | Galvanize Therapeutics, Inc. | Methods, apparatuses, and systems for the treatment of pulmonary disorders |
US10939958B2 (en) | 2016-06-27 | 2021-03-09 | Galary, Inc. | Methods, apparatuses, and systems for the treatment of pulmonary disorders |
US10702337B2 (en) | 2016-06-27 | 2020-07-07 | Galary, Inc. | Methods, apparatuses, and systems for the treatment of pulmonary disorders |
Also Published As
Publication number | Publication date |
---|---|
WO1999064109A1 (en) | 1999-12-16 |
JP2009000545A (en) | 2009-01-08 |
US6411852B1 (en) | 2002-06-25 |
JP2002517295A (en) | 2002-06-18 |
AU4430499A (en) | 1999-12-30 |
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