US20040158313A1 - Pulmonary vein stent and method for use - Google Patents
Pulmonary vein stent and method for use Download PDFInfo
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- US20040158313A1 US20040158313A1 US10/765,507 US76550704A US2004158313A1 US 20040158313 A1 US20040158313 A1 US 20040158313A1 US 76550704 A US76550704 A US 76550704A US 2004158313 A1 US2004158313 A1 US 2004158313A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2002/821—Ostial stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
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Abstract
Description
- This patent application is a continuation of U.S. App. Ser. No. 09/687,776, now U.S. Pat. No. ______, which claims priority to provisional patent application 60/159,343, filed Oct. 13, 1999.
- The inventions described below relate to the field of implantable medical devices. Specifically the invention relates to endoluminally placed prosthesis known as stents. More specifically, the invention relates to the placement of stents in the pulmonary veins which have advantages for the treatment of atrial fibrillation.
- Atrial fibrillation (AF) is a form of heart disease that afflicts millions of people. It is a condition in which the normal contraction of the heart is interrupted, primarily by abnormal and uncontrolled action of the atria of the heart. The heart has four chambers: the right atrium, right ventricle, the left ventricle, and the left atrium. The right atrium pumps de-oxygenated blood from the vena cava to the right ventricle, which pumps the blood to the lungs, necessary for return flow of de-oxygenated blood from the body. The right atrium contracts to squeeze blood into the right ventricle, and expands to suck blood from the vena cava. The left atrium pumps oxygenated blood from the pulmonary veins (returning from the lungs), necessary for flow of oxygenated blood from the lungs. The left atrium contracts to squeeze blood into the left ventricle, which then pumps the blood into the aorta and thence to the entire body, and expands to suck blood from the pulmonary veins. The contractions of the atria normally occur in a controlled sequence with the contractions of the other chambers of the heart. When the left atrium or the right atrium fails to contract, contracts out of sequence, or contracts ineffectively, blood flow within the heart is disrupted. The disruption of the normal rhythm of contraction is referred to as an arrhythmia. The arrhythmia, known as atrial fibrillation, can cause weakness of the heart due to reduced ventricular filling and reduced cardiac output, stroke due to clot formation in a poorly contracting atria, which may lead to brain damage and death, and even life threatening ventricular arrhythmias.
- There is a broad spectrum of situations which fall under the broad heading of AF. For example, in older patients where there is substantial heterogeneity in the conduction within the atrial tissue, the patient is said to have the tissue substrate for AF such that any trigger will result in maintaining AF. In younger patients, the tissue may have more homogeneous conduction and be less likely to have sustained AF. In the younger patient it may be the often reoccurrence of a premature depolarizing tissue which acts as a trigger that causes the clinical manifestation of problematic episodes of AF. Clearly, there is a continuous spectrum of degrees of triggered AF and conduction heterogeneity which acts as a substrate for this arrhythmia, and it is appropriate that a number of medical therapies are being developed to treat this disease.
- Atrial fibrillation may be treated with an atrial defibrillator. Atrial defibrillators are typically implantable electrical therapy devices which deliver defibrillating energy to the atrium to terminate arrhythmias. They sense the electrical activity of the atrium and deliver an electrical shock to the atrium when the electrical activity indicates that the atrium is in fibrillation. Electrical defibrillation has two major problems: the therapy causes substantial pain, and has the potential to initiate a life threatening ventricular arrhythmias. The pain associated with the electrical shock is severe and unacceptable for many patients. Unlike electrical ventricular defibrillators, where the patient loses consciousness prior to receiving therapy, the patient who suffers an atrial arrhythmia is conscious and alert when the device delivers electrical therapy.
- The potential for inappropriate induction of ventricular fibrillation by the shock intended to defibrillate the atrium exists. The induction of ventricular fibrillation has great potential to result in death in just a few minutes if no intervening therapy is provided. Even with careful algorithms to deliver shocks to the periods in the ventricular contraction cycle when the heart is not susceptible to shock induced ventricular fibrillation, the risk of setting off a ventricular fibrillation remains substantial.
- Doctors have treated atrial fibrillation with drugs injected intravenously or administered orally. Recent literature describes the potential for the delivery of drugs to the heart on demand to terminate arrhythmias. The concept has been suggested for use in the atrium to treat atrial fibrillation. Arzbaecher, Pharmacologic Atrial Defibrillator and Method, U.S. Pat. No. 5,527,344 (Jun. 18, 1996) describes a pharmacological atrial defibrillator and method for automatically delivering a defibrillating drug into the bloodstream of a patient upon detection of atrial arrhythmias in order to terminate the atrial arrhythmias. Arzbaecher teaches that unspecified defibrillating drugs should be injected into the bloodstream with a large initial dose followed by delivery of a continuous smaller dose (this is the “two-compartment pharmacokinetic model” discussed in the Arzbaecher patent). By delivering agents to a blood vessel and maintaining a therapeutic level of drugs in the blood stream, Arzbaecher requires systemic effects to be achieved in order to terminate atrial arrhythmias. In other words, if drugs injected according to Arzbaecher are to have any effective concentrations within the heart, then a large amount must be injected in the blood stream to ensure that an adequate dose is delivered to the affected area of the heart. While the drugs are in the blood stream, they are available throughout the body to cause side effects on all other organs.
- There are several disadvantages to the transient introduction of systemic drug levels by an implantable device. Systemic effects resulting from such delivery may result in detrimental effects to ventricular cardiac conduction. These detrimental effects could be life threatening, and several studies suggest that use of these drugs actually leads to higher mortality. The large amount of drugs required for systemic delivery of therapeutic doses demands a larger, less comfortable device than smaller dosages would allow. The large quantity of drug in the implantable reservoir of such a system is potentially more dangerous if it develops a leak or is ruptured. Such a large single dosage requires a reservoir that requires frequent follow-ups for refilling post therapy by a clinician. Lastly, the large quantity of drugs required to obtain therapeutic levels in the entire body may cost substantially more than that required to treat a specific site within the heart.
- Atrial fibrillation can be treated by atrial ablation. There are two general approaches for providing ablative therapy to the heart for the treatment of atrial fibrillation. These shall be called the long linear ablative lesion approach and the focal ablation approach.
- In the long linear lesion approach, the heart tissue is killed along a linear pathway. The cardiac electrophysiologist does this to segment the heart into regions which are too small to sustain atrial fibrillation. Such an approach is very similar to performing the Maze procedure using radiofrequency, microwave, and ultrasound ablative energy sources on the end of catheters. In the Maze procedure, a number of incisions are made with a scalpel in an attempt to terminate inappropriate accessory pathways.
- In the focal ablation approach, the heart tissue is killed at a single site. The cardiac electrophysiologist attempts to ablate the region of the heart that prematurely depolarizes, and which has been described as acting as a trigger for the initiation of atrial fibrillation. Recently, work in ablating regions at the junction of the pulmonary veins and the left atrium has been performed. Such ablations remove the possibility of triggers for AF initiating within the pulmonary veins, or at the region near the junction of the veins with the left atrial tissue. Such ablations may also remove disturbances introduced into the conduction pathway by the heterogeneity of the junction region anatomy.
- Focal ablation of the region within or adjacent to the pulmonary vein to terminate atrial fibrillation with different energy transfer techniques such as cryoablation, RF ablation, laser ablation, ultrasound ablation, and microwave ablation causes damage to the tissue which may affect the viability of the tissue. By placing a stent, a vascular endoprosthesis, within a target pulmonary vein it is possible to protect the functionality of the veins after the ablation procedure.
- In some cases, placement of a stent, endoprosthesis or mere circuit interrupting structure into the pulmonary veins prevents aberrant electrical activity in the pulmonary veins from interfering with the electrical activity of the left atrium and thereby eliminate the need for destructive ablation. The stent, endoprosthesis or circuit interrupting structure may be coated or comprised of a drug-eluting compound, loaded with a drug which inhibits arrhythmia. Embodiments include a new indication for maintaining vessel patency after a destructive ablation procedure, and the use of a stent both with and without local drug delivery to disrupt the electrical contribution of the pulmonary veins to atrial electrical activity leading to the induction and maintenance of atrial fibrillation.
- FIG. 1 is a cross-sectional view of the left atrium with the stent deployed into the target pulmonary vein.
- FIG. 2 is a schematic of a drug elution stent.
- FIG. 3 is a schematic of a drug elution stent where only a narrow band of the stent is covered with a drug eluting compound.
- FIG. 4 is a schematic of a drug elution stent having a uniform coating of drug eluting compound and a coating covering a substantial portion of the stent such that the drug is eluted from a narrow band of the stent.
- FIG. 5 is an isometric view of the left atrium having a stent deployed into the ostium of the target pulmonary vein, wherein the drug-eluting band is proximate the left atrium.
- In FIG. 1 the
stent 1 has been deployed, by thecatheter 2, into theostium 3 of the targetpulmonary vein 4. The stent alone acts to isolate the electrical impulses of the pulmonary veins from the atrial conduction tissue. The stent, endoprosthesis or circuit interrupting structure is placed into the ostium of the target pulmonary veins. The term “stent” is being used in its broad sense as is meant to encompass a stent, endoprosthesis or a circuit interrupting structure. The stent, when fabricated of a material with desirable electrical properties (for example, metal, which has a low resistivity) may comprise the circuit interrupting structure. To place the stent in the target pulmonary vein, access to theleft atrium 5 is first gained by percutaneous insertion of a catheter into the left atrium. To accomplish this, a needle catheter is placed through the venous system into the right atrium, and then penetrates the fossa ovalis 6 (the atrial septum) to gain access to the left atrium. Access to the right atrium (not shown) can be through the femoral vein in the thigh and the inferior vena cava, or may be through the subclavian vein, brachial vein or cephalic vein, etc., in the shoulder and arm, and then through the superior vena cava. A catheter sheath 7, such as a guiding catheter, is advanced over the needle catheter and is inserted into the left atrium. The needle catheter is then removed, and a stent delivery catheter is inserted with a stent loaded on the distal end of the catheter. The distal end of the catheter is then maneuvered into the left atrium and into the target pulmonary veins. Location of the stent is confirmed and the stent is expanded or released, and expanded to the point where it securely engages the wall of the pulmonary vein. If necessary, the stent may be pressed into the wall of the pulmonary vein, and may have fastening appendages such as barbs, to more securely attach to the pulmonary vein wall. - As previously noted, placement of the stent alone can act to isolate the target pulmonary vein from the atrial conduction and excitation process. The primary advantage of this method is that no tissue is damaged. The ramifications regarding the viability of the pulmonary veins long term is obvious. Less obvious is the fact that the non-damaging procedure can be reversed, if desired. This stent device may operate by acting as an electrically insulative barrier to an electrical signal, a capacitively coupled short across the region of tissue in question, an averager that reduces the effective signal of the myocardial region in question, a substrate for the delivery of pharmacological agents to alter the electrical excitation and conduction properties of the local tissue region, or any combination of these mechanisms. The preferred embodiment incorporates local delivery of therapeutic agents to a region equivalent to the lumen wall on the outer wall of the stent.
- Where placement of the stent is accomplished without an accompanying ablation procedure, the device may be fabricated in various forms. A nonconductive embodiment of any of the different possible geometries of the device will act as an insulative barrier preventing conduction through the device, and acting similarly to a region of necrotic tissue created by ablation. There is one fundamental difference: the device disclosed here changes the cellular conductivity locally without destroying tissue.
- The conductive embodiments of the device act as a short across the pulmonary vein region which may introduce a triggered premature depolarization of cells. By electrically connecting the tissue around the arrhythmogenic site, the cells on either side of a conductive device will be coupled capacitively to the device and therefore to each other.
- Metals are very efficient conductors of electrons, but not for ions. On the other hand, aqueous electrolyte solutions are ionic conductors and are hostile to electrons. Consequently, at the interface between a metal and an aqueous electrolyte solution, there is a mismatch in the type of charge carrier used. In the absence of a chemical mechanism to convert one type of charge into the other, the interface behaves as a capacitance: a change in the electronic charge density on the metal side is accompanied by a compensating change in ionic charge density on the solution side, so that electroneutrality is maintained.
- The two types of charges can come very close to each other spatially without the possibility of neutralizing each other. This gives rise to an interfacial capacitance. [de Levie, Robert: The Admittance of the Interface between a Metal Electrode and an Aqueous Electrolyte Solution: Some Problems and Pitfalls, pp337-347 Annals of Biomedical Engineering, Special Issue]. Typically the interface between a metal and tissue is modeled as a resistor and a capacitor in parallel; at low currents the impedance associated with the capacitive leg of the circuit is small and the impedance associated with the resistive leg is large. Thus, any electrical discharge from electrically active tissue on the pulmonary vein side of the stent, or underlying the stent, will be hindered in its transmission to the atrium thereby limiting its ability to initiate an atrial fibrillation in the left atrium. Different biocompatible metals such as Platinum Iridium Alloys, MP35N, Titanium, nitinol, and Stainless Steels may be selected for different capacitive and resistive effects.
- If pulmonary vein ablation is to be performed as the primary therapy and the stent is to be used to maintain pulmonary vein patency after ablation, then the necessary ablation catheter is passed through the catheter sheath into the left atrium to gain access to the pulmonary veins and perform the ablation prior to stent placement. The ablation catheter may be placed within the opening of the pulmonary veins or adjacent to the pulmonary veins to produce lesions using radiofrequency, ultrasound, microwave, laser, cryogenic or other energy transfer means as well as chemical means to kill the tissue locally. The damaged pulmonary vein or veins are now at risk for stenosis and stenting the pulmonary vein avoids the resulting pulmonary hypertension or occlusion. Stenting is performed by removing the ablation catheter of choice, and inserting a stenting catheter. The stenting catheter may use balloon expandable, self-expanding, or other types of expanding stents to maintain the patency of the pulmonary vein.
- After one or more stents are placed in the pulmonary veins, with one or more catheters swapped out through the catheter sheath, the catheter sheath is removed, and the patient is closed. In most cases the opening through the fossa ovalis is very small and it heals up on its own. However, it is conceivable that a repair may be required in some patients using catheter techniques developed for closing septal defects.
- The stent may be coated with a drug delivery compound or it may be partially made of a drug delivery compound. The stent is placed such that it delivers a sustained release of an antiarrhythmic drug which affects conduction locally. There are a number of viable pharmacologic therapies available. Drugs that predominantly affect slow pathway conduction include digitalis, calcium channel blockers, and beta-blockers. Drugs that predominantly prolong refractoriness, or time before a heart cell can be activated, produce conduction block in either the fast pathway or in accessory AV connections including the class IA antiarrhythmic agents (quinidine, procainimide, and disopyrimide) or class IC drugs (flecainide and propafenone). The class III antiarrhythmic agents (sotolol or amiodorone) prolong refractoriness and delay or block conduction over fast or slow pathways as well as in accessory AV connections. Temporary blockade of slow pathway conduction is usually achieved by intravenous administration of adenosine or verapamil. [Scheinman, Melvin: Supraventricular Tachycardia: Drug Therapy Versus Catheter Ablation, Clinical Cardiology Vol. 17, Supp. II-11-II-15 (1994)]. Other agents such as encainide, diltiazem, and nickel chloride are also available.
- As in FIGS. 2, 3, and4, the drugs may be placed on the
stent 1 in adrug eluting coating 8. The drug eluting coating may be placed uniformly over the outer wall of the stent as in FIG. 2 or they may be placed in a narrow circumferential band on the proximal end of the stent as in FIG. 3. This band creates a short longitudinal segment of the stent which is capable of eluting drugs into the surrounding pulmonary vein. The remaining longitudinal segment of the stent is not covered with a drug-eluting compound. The stent is placed into the targetpulmonary vein 4 such that the drug-eluting band is on the end of the stent nearest the left atrium after placement, as in FIG. 5. - As shown in FIG. 4, the drugs may be placed uniformly over or within the entire stent, while only a
small band 9 is permitted to elute drugs outward into the pulmonary vein wall. This is accomplished by having acoating 10 covering a substantial longitudinal portion of the stent which prevents elution of the drug, thus leaving a small circumferential band which allows elution of the drug into the target pulmonary vein. The coating impedes the elution of drugs from the portion of the stent which is covers. This coating may a thin layer of polyurethane or any other biocompatible coating impervious to the drug to be eluted. Having asmall region 9 through which the drugs are eluted increases the ratio of drug volume to elution surface area. In other words, the large amount of drug-eluting compound can only be eluted through the small surface area, thus, increasing the ratio of drug volume to elution surface area. Where the stent is made of a polymer or hydrogel, the entire stent material may be loaded with the eluting drug. - The methods and devices described above can be accomplished with many embodiments of stents. Additionally, many stent materials and drug compounds may be substituted for the materials and drugs described. Thus, while the preferred embodiments of the devices and methods have been described in reference to the environment in which they were developed, they are merely illustrative of the principles of the inventions. Other embodiments and configurations may be devised without departing from the spirit of the inventions and the scope of the appended claims.
Claims (39)
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US10/765,507 US20040158313A1 (en) | 1999-10-13 | 2004-01-26 | Pulmonary vein stent and method for use |
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US15934399P | 1999-10-13 | 1999-10-13 | |
US09/687,776 US6716242B1 (en) | 1999-10-13 | 2000-10-13 | Pulmonary vein stent and method for use |
US10/765,507 US20040158313A1 (en) | 1999-10-13 | 2004-01-26 | Pulmonary vein stent and method for use |
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US09/687,776 Continuation US6716242B1 (en) | 1999-10-13 | 2000-10-13 | Pulmonary vein stent and method for use |
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US10/744,823 Abandoned US20040153139A1 (en) | 1999-10-13 | 2003-12-22 | Pulmonary vein stent and method for use |
US10/765,507 Abandoned US20040158313A1 (en) | 1999-10-13 | 2004-01-26 | Pulmonary vein stent and method for use |
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Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US20060039946A1 (en) * | 2004-08-20 | 2006-02-23 | Medtronic Inc. | Drug eluting medical device |
US20060116666A1 (en) * | 2004-10-08 | 2006-06-01 | Sinus Rhythm Technologies, Inc. | Two-stage scar generation for treating atrial fibrillation |
US20090177262A1 (en) * | 2006-04-26 | 2009-07-09 | Carlos Oberti | Apparatus and method for treating cardiovascular diseases |
US20100081914A1 (en) * | 2008-09-26 | 2010-04-01 | Waynik Jeffrey M | Method and apparatus for positioning a guide relative to a base |
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US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
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US9526572B2 (en) | 2011-04-26 | 2016-12-27 | Aperiam Medical, Inc. | Method and device for treatment of hypertension and other maladies |
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US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
US9884076B2 (en) | 2012-06-05 | 2018-02-06 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
US11253551B2 (en) | 2016-01-11 | 2022-02-22 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
US11357799B2 (en) | 2014-10-03 | 2022-06-14 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
US11759482B2 (en) | 2017-04-19 | 2023-09-19 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
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US20160193059A1 (en) * | 2011-05-12 | 2016-07-07 | Aperiam Medical, lnc. | Intraluminal implants and methods |
US9752144B2 (en) | 2014-08-04 | 2017-09-05 | MiRagen Therapeutics, Inc. | Inhibitors of MYH7B and uses thereof |
KR20170068452A (en) | 2014-09-08 | 2017-06-19 | 미라젠 세러퓨틱스 인코포레이티드 | MIR-29 Mimics and Uses Thereof |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4986270A (en) * | 1987-10-06 | 1991-01-22 | Leonard Bloom | Hemodynamically responsive system for and method of treating a malfunctioning heart |
US5507743A (en) * | 1993-11-08 | 1996-04-16 | Zomed International | Coiled RF electrode treatment apparatus |
US6012457A (en) * | 1997-07-08 | 2000-01-11 | The Regents Of The University Of California | Device and method for forming a circumferential conduction block in a pulmonary vein |
US6136025A (en) * | 1999-07-27 | 2000-10-24 | Barbut; Denise R. | Endoscopic arterial pumps for treatment of cardiac insufficiency and venous pumps for right-sided cardiac support |
US6164283A (en) * | 1997-07-08 | 2000-12-26 | The Regents Of The University Of California | Device and method for forming a circumferential conduction block in a pulmonary vein |
US20020026944A1 (en) * | 1997-07-11 | 2002-03-07 | Walid Najib Aboul-Hosn | Pulmonary and circulatory blood flow support devices and methods for heart surgery procedures |
US6385489B1 (en) * | 1998-09-25 | 2002-05-07 | Ep Medsystems, Inc. | Triple array defibrillation catheter and method of using the same |
US6402746B1 (en) * | 1996-12-19 | 2002-06-11 | Ep Technologies, Inc. | Branched structures for supporting multiple electrode elements |
US20030018362A1 (en) * | 2001-06-15 | 2003-01-23 | Chris Fellows | Ablation stent for treating atrial fibrillation |
US6632223B1 (en) * | 2000-03-30 | 2003-10-14 | The General Hospital Corporation | Pulmonary vein ablation stent and method |
US6716242B1 (en) * | 1999-10-13 | 2004-04-06 | Peter A. Altman | Pulmonary vein stent and method for use |
US6814733B2 (en) * | 2002-01-31 | 2004-11-09 | Biosense, Inc. | Radio frequency pulmonary vein isolation |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5500013A (en) | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5538504A (en) * | 1992-07-14 | 1996-07-23 | Scimed Life Systems, Inc. | Intra-extravascular drug delivery catheter and method |
US5921982A (en) * | 1993-07-30 | 1999-07-13 | Lesh; Michael D. | Systems and methods for ablating body tissue |
US5527344A (en) | 1994-08-01 | 1996-06-18 | Illinois Institute Of Technology | Pharmacologic atrial defibrillator and method |
US5609151A (en) | 1994-09-08 | 1997-03-11 | Medtronic, Inc. | Method for R-F ablation |
US5891108A (en) | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6113567A (en) | 1995-10-25 | 2000-09-05 | Becker; Bruce B. | Lacrimal silicone tube with reduced friction |
US5899917A (en) | 1997-03-12 | 1999-05-04 | Cardiosynopsis, Inc. | Method for forming a stent in situ |
US6511477B2 (en) * | 1997-03-13 | 2003-01-28 | Biocardia, Inc. | Method of drug delivery to interstitial regions of the myocardium |
US6024740A (en) | 1997-07-08 | 2000-02-15 | The Regents Of The University Of California | Circumferential ablation device assembly |
US6251109B1 (en) | 1997-06-27 | 2001-06-26 | Daig Corporation | Process and device for the treatment of atrial arrhythmia |
US6117101A (en) | 1997-07-08 | 2000-09-12 | The Regents Of The University Of California | Circumferential ablation device assembly |
US7208010B2 (en) * | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
US6064902A (en) | 1998-04-16 | 2000-05-16 | C.R. Bard, Inc. | Pulmonary vein ablation catheter |
US6206914B1 (en) * | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
US6605294B2 (en) * | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
US20040215310A1 (en) * | 2002-01-17 | 2004-10-28 | Omar Amirana | Stent and delivery method for applying RF energy to a pulmonary vein and the atrial wall around its ostium to eliminate atrial fibrillation while preventing stenosis of the pulmonary vein thereafter |
US7192438B2 (en) * | 2002-11-08 | 2007-03-20 | Margolis James R | Device and method for electrical isolation of the pulmonary veins |
US7195628B2 (en) * | 2002-12-11 | 2007-03-27 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Atrial fibrillation therapy with pulmonary vein support |
-
2000
- 2000-10-13 US US09/687,776 patent/US6716242B1/en not_active Expired - Lifetime
-
2003
- 2003-12-22 US US10/744,823 patent/US20040153139A1/en not_active Abandoned
-
2004
- 2004-01-26 US US10/765,507 patent/US20040158313A1/en not_active Abandoned
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4986270A (en) * | 1987-10-06 | 1991-01-22 | Leonard Bloom | Hemodynamically responsive system for and method of treating a malfunctioning heart |
US5507743A (en) * | 1993-11-08 | 1996-04-16 | Zomed International | Coiled RF electrode treatment apparatus |
US6402746B1 (en) * | 1996-12-19 | 2002-06-11 | Ep Technologies, Inc. | Branched structures for supporting multiple electrode elements |
US6012457A (en) * | 1997-07-08 | 2000-01-11 | The Regents Of The University Of California | Device and method for forming a circumferential conduction block in a pulmonary vein |
US6164283A (en) * | 1997-07-08 | 2000-12-26 | The Regents Of The University Of California | Device and method for forming a circumferential conduction block in a pulmonary vein |
US20020026944A1 (en) * | 1997-07-11 | 2002-03-07 | Walid Najib Aboul-Hosn | Pulmonary and circulatory blood flow support devices and methods for heart surgery procedures |
US6385489B1 (en) * | 1998-09-25 | 2002-05-07 | Ep Medsystems, Inc. | Triple array defibrillation catheter and method of using the same |
US6136025A (en) * | 1999-07-27 | 2000-10-24 | Barbut; Denise R. | Endoscopic arterial pumps for treatment of cardiac insufficiency and venous pumps for right-sided cardiac support |
US6716242B1 (en) * | 1999-10-13 | 2004-04-06 | Peter A. Altman | Pulmonary vein stent and method for use |
US6632223B1 (en) * | 2000-03-30 | 2003-10-14 | The General Hospital Corporation | Pulmonary vein ablation stent and method |
US20030018362A1 (en) * | 2001-06-15 | 2003-01-23 | Chris Fellows | Ablation stent for treating atrial fibrillation |
US6814733B2 (en) * | 2002-01-31 | 2004-11-09 | Biosense, Inc. | Radio frequency pulmonary vein isolation |
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US8840658B2 (en) | 2003-03-03 | 2014-09-23 | Syntach Ag | Electrical conduction block implant device |
US8846396B2 (en) | 2003-07-31 | 2014-09-30 | Universita Degli Studi Di Roma “La Sapienza” | Methods for the isolation of cardiac stem cells |
US8772030B2 (en) | 2003-07-31 | 2014-07-08 | Universita Degli Studi Di Roma “La Sapienza” | Cardiac stem cells and methods for isolation of same |
US9295484B2 (en) | 2003-11-17 | 2016-03-29 | Syntach Ag | Device, a kit and a method for treatment of disorders in the heart rhythm regulation system |
US8257376B2 (en) | 2003-11-17 | 2012-09-04 | Syntach Ag | Device, a kit and a method for treatment of disorders in the heart rhythm regulation system |
US9398967B2 (en) | 2004-03-02 | 2016-07-26 | Syntach Ag | Electrical conduction block implant device |
US20060039946A1 (en) * | 2004-08-20 | 2006-02-23 | Medtronic Inc. | Drug eluting medical device |
WO2006023859A1 (en) * | 2004-08-20 | 2006-03-02 | Medtronic, Inc. | Medical device with tissue-dependent drug elution |
US20090171444A1 (en) * | 2004-10-08 | 2009-07-02 | Richard Cornelius | Two-Stage Scar Generation for Treating Atrial Fibrillation |
US20060116666A1 (en) * | 2004-10-08 | 2006-06-01 | Sinus Rhythm Technologies, Inc. | Two-stage scar generation for treating atrial fibrillation |
US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
US8112292B2 (en) | 2006-04-21 | 2012-02-07 | Medtronic Navigation, Inc. | Method and apparatus for optimizing a therapy |
US20090177262A1 (en) * | 2006-04-26 | 2009-07-09 | Carlos Oberti | Apparatus and method for treating cardiovascular diseases |
US8652201B2 (en) * | 2006-04-26 | 2014-02-18 | The Cleveland Clinic Foundation | Apparatus and method for treating cardiovascular diseases |
US9597154B2 (en) | 2006-09-29 | 2017-03-21 | Medtronic, Inc. | Method and apparatus for optimizing a computer assisted surgical procedure |
US8660635B2 (en) | 2006-09-29 | 2014-02-25 | Medtronic, Inc. | Method and apparatus for optimizing a computer assisted surgical procedure |
US20100081914A1 (en) * | 2008-09-26 | 2010-04-01 | Waynik Jeffrey M | Method and apparatus for positioning a guide relative to a base |
US8165658B2 (en) | 2008-09-26 | 2012-04-24 | Medtronic, Inc. | Method and apparatus for positioning a guide relative to a base |
US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
US9526572B2 (en) | 2011-04-26 | 2016-12-27 | Aperiam Medical, Inc. | Method and device for treatment of hypertension and other maladies |
US9884076B2 (en) | 2012-06-05 | 2018-02-06 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
US11220687B2 (en) | 2012-08-13 | 2022-01-11 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
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US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
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