US20040120896A1 - Buccal, polar and non-polar spray or capsule containing drugs for treating pain - Google Patents
Buccal, polar and non-polar spray or capsule containing drugs for treating pain Download PDFInfo
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- US20040120896A1 US20040120896A1 US10/726,625 US72662503A US2004120896A1 US 20040120896 A1 US20040120896 A1 US 20040120896A1 US 72662503 A US72662503 A US 72662503A US 2004120896 A1 US2004120896 A1 US 2004120896A1
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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Abstract
Description
- This application is a continuation-in-part of application Ser. No. 09/537,118, filed Mar. 29, 2000 which is a continuation-in-part of the U.S. national phase designation of PCT/US97/17899 filed Oct. 1, 1997, the disclosures of which are incorporated by reference herein in their entirety.
- It is known that certain biologically active compounds are better absorbed through the oral mucosa than through other routes of administration, such as through the stomach or intestine. However, formulations suitable for such administration by these latter routes present their own problems. For example, the biologically active compound must be compatible with the other components of the composition such as propellants, solvents, etc. Many such formulations have been proposed. For example, U.S. Pat. No. 4,689,233, Dvorsky et al., describes a soft gelatin capsule for the administration of the anti-coronary drug nifedipine dissolved in a mixture of polyether alcohols. U.S. Pat. No. 4,755,389, Jones et al., describes a hard gelatin chewable capsule containing nifedipine. A chewable gelatin capsule containing a solution or dispersion of a drug is described in U.S. Pat. No. 4,935,243, Borkan et al. U.S. Pat. No. 4,919,919, Aouda et al, and U.S. Pat. No. 5,370,862, Klokkers-Bethke, describe a nitroglycerin spray for administration to the oral mucosa comprising nitroglycerin, ethanol, and other components. An orally administered pump spray is described by Cholcha in U.S. Pat. No. 5,186,925. Aerosol compositions containing a hydrocarbon propellant and a drug for administration to a mucosal surface are described in U.K. 2,082,457, Su, U.S. Pat. No. 3,155,574, Silson et al., U.S. Pat. No. 5,011,678, Wang et al., and by Parnell in U.S. Pat. No. 5,128,132. It should be noted that these references discuss bioavailability of solutions by inhalation rather than through the membranes to which they are administered.
- A buccal aerosol spray or soft bite gelatin capsule using a polar or non-polar solvent has now been developed which provides biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect.
- The buccal aerosol spray compositions of the present invention, for transmucosal administration of a pharmacologically active compound soluble in a pharmacologically acceptable non-polar solvent comprise in weight % of total composition: pharmaceutically acceptable propellant 5-80%, nonpolar solvent 19-85%, active compound 0.05-50%, suitably additionally comprising, by weight of total composition a flavoring agent 0.01-10%. Preferably the composition comprises: propellant 10-70%, non-polar solvent 25-89.9%, active compound 0.01-40%, flavoring agent 1-8%; most suitably propellant 20-70%, non-polar solvent 25-74.75%, active compound 0.25-35%, flavoring agent 2-7.5%.
- The buccal polar aerosol spray compositions of the present invention, for transmucosal administration of a pharmacologically active compound soluble in a pharmacologically acceptable polar solvent are also administrable in aerosol form driven by a propellant. In this case, the composition comprises in weight % of total composition: aqueous polar solvent 10-97%, active compound 0.1-25%, suitably additionally comprising, by weight of total composition a flavoring agent 0.05-10% and propellant: 2-10%. Preferably the composition comprises: polar solvent 20-97%, active compound 0.1-15%, flavoring agent 0.1-5% and propellant 2-5%; most suitably polar solvent 25-97%, active compound 0.2-25%, flavoring agent 0.1-2.5% and propellant 2-4%.
- The buccal pump spray composition of the present invention, i.e., the propellant free composition, for transmucosal administration of a pharmacologically active compound wherein said active compound is soluble in a pharmacologically acceptable non-polar solvent comprises in weight % of total composition: non-polar solvent 30-99.69%, active compound 0.005-55%, and suitably additionally, flavoring agent 0.1-10%.
- The buccal polar pump spray compositions of the present invention, i.e., the propellant free composition, for transmucosal administration of a pharmacologically active compound soluble in a pharmacologically acceptable polar solvent comprises in weight % of total composition: aqueous polar solvent 30-99.69%, active compound 0.001-60%, suitably additionally comprising, by weight of total composition a flavoring agent 0.1-10%. Preferably the composition comprises: polar solvent 37-98.58%, active compound 0.005-55%, flavoring agent 0.5-8%; most suitably polar solvent 60.9-97.06%, active compound 0.01-40%, flavoring agent 0.75-7.5%.
- The soft bite gelatin capsules of the present invention for transmucosal administration of a pharmacologically active compound, at least partially soluble in a pharmacologically acceptable non-polar solvent, having charged thereto a fill composition comprise in weight % of total composition: non-polar solvent 4-99.99%, emulsifier 0-20%, active compound 0.01-80%, provided that said fill composition contains less than 10% of water, suitably additionally comprising, by weight of the composition: flavoring agent 0.01-10%. Preferably, the soft bite gelatin capsule comprises: non-polar solvent 21.5-99.975%, emulsifier 0-15%, active compound 0.025-70%, flavoring agent 1-8%; most suitably: nonpolar solvent 28.5-97.9%, emulsifier 0-10%, active compound 0.1-65.0%, flavoring agent 2-6%.
- The soft bite polar gelatin capsules of the present invention for transmucosal administration of a pharmacologically active compound, at least partially soluble in a pharmacologically acceptable polar solvent, having charged thereto a composition comprising in weight % of total composition: polar solvent 25-99.89%, emulsifier 0-20%, active compound 0.01-65%, provided that said composition contains less than 10% of water, suitably additionally comprising, by weight of the composition: flavoring agent 01-10%. Preferably, the soft bite gelatin capsule comprises: polar solvent 37-99.95%, emulsifier 0-15%, active compound 0.025-55%, flavoring agent 1-8%; most suitably: polar solvent 44-96.925%, emulsifier 0-10%, active compound 0.075-50%, flavoring agent 2-6%.
- It is an object of the invention to coat the mucosal membranes either with extremely fine droplets of spray containing the active compounds or a solution or paste thereof from bite capsules.
- It is also an object of the invention to administer to the oral mucosa of a mammalian in need of same, preferably man, by spray or bite capsule, a predetermined amount of a biologically active compound by this method or from a soft gelatin capsule.
- A further object is a sealed aerosol spray container containing a composition of the non polar or polar aerosol spray formulation, and a metered valve suitable for releasing from said container a predetermined amount of said composition.
- As the propellant evaporates after activation of the aerosol valve, a mist of fine droplets is formed which contains solvent and active compound.
- The propellant is a non-Freon material, preferably a C3-8 hydrocarbon of a linear or branched configuration. The propellant should be substantially non-aqueous. The propellant produces a pressure in the aerosol container such that under expected normal usage it will produce sufficient pressure to expel the solvent from the container when the valve is activated but not excessive pressure such as to damage the container or valve seals.
- The non-polar solvent is a non-polar hydrocarbon, preferably a C7-18 hydrocarbon of a linear or branched configuration, fatty acid esters, and triglycerides, such as miglyol. The solvent must dissolve the active compound and be miscible with the propellant, i.e., solvent and propellant must form a single phase at a temperature of 0-40° C. a pressure range of between 1-3 atm.
- The polar and non-polar aerosol spray compositions of the invention are intended to be administered from a sealed, pressurized container. Unlike a pump spray, which allows the entry of air into the container after every activation, the aerosol container of the invention is sealed at the time of manufacture. The contents of the container are released by activation of a metered valve, which does not allow entry of atmospheric gasses with each activation. Such containers are commercially available.
- A further object is a pump spray container containing a composition of the pump spray formulation, and a metered valve suitable for releasing from said container a predetermined amount of said composition.
- A further object is a soft gelatin bite capsule containing a composition of as set forth above. The formulation may be in the form of a viscous solution or paste containing the active compounds. Although solutions are preferred, paste fills may also be used where the active compound is not soluble or only partially soluble in the solvent of choice. Where water is used to form part of the paste composition, it should not exceed 10% thereof. (All percentages herein are by weight unless otherwise indicated.)
- The polar or non-polar solvent is chosen such that it is compatible with the gelatin shell and the active compound. The solvent preferably dissolves the active compound. However, other components wherein the active compound is not soluble or only slightly soluble may be used and will form a paste fill.
- Soft gelatin capsules are well known in the art. See, for example, U.S. Pat. No. 4,935,243, Borkan et al., for its teaching of such capsules. The capsules of the present invention are intended to be bitten into to release the low viscosity solution or paste therein, which will then coat the buccal mucosa with the active compounds. Typical capsules, which are swallowed whole or bitten and then swallowed, deliver the active compounds to the stomach, which results in significant lag time before maximum blood levels can be achieved or subject the compound to a large first pass effect. Because of the enhanced absorption of the compounds through the oral mucosa and no chance of a first pass effect, use of the bite capsules of the invention will eliminate much of the lag time, resulting in hastened onset of biological effect. The shell of a soft gelatin capsule of the invention may comprise, for example: gelatin: 50-75%, glycerin 20-30%, colorants 0.5-1.5%, water 5-10%, and sorbitol 2-10%.
- The active compound may include, biologically active peptides, central nervous system active amines, sulfonyl ureas, antibiotics, antifungals, antivirals, sleep inducers, antiasthmatics, bronchial dilators, antiemetics, histamine H-2 receptor antagonists, barbiturates, prostaglandins and neutraceuticals.
- The active compounds may also include antihistamines, alkaloids, hormones, benzodiazepines and narcotic analgesics. While not limited thereto, these active compounds are particularly suitable for non-polar pump spray formulation and application.
- The active compounds may also include nerve impulse inhibitors, anti-opioid agents, anti-migraine agents, anti-muscle spasm agents, pain control agents, anesthetics, anti-inflammatory drugs, or mixtures thereof.
- FIG. 1. is a schematic diagram showing routes of absorption and processing of pharmacologically active substances in a mammalian system.
- The preferred active compounds of the present invention are in an ionized, salt form or as the free base of the pharmaceutically acceptable salts thereof (provided, for the aerosol or pump spray compositions, they are soluble in the spray solvent). These compounds are soluble in the non-polar solvents of the invention at useful concentrations or can be prepared as pastes at useful concentrations. These concentrations may be less than the standard accepted dose for these compounds since there is enhanced absorption of the compounds through the oral mucosa. This aspect of the invention is especially important when there is a large (40-99.99%) first pass effect.
- As propellants for the non polar sprays, propane, N-butane, iso-butane, N-pentane, iso-pentane, and neo-pentane, and mixtures thereof may be used. N-butane and iso-butane, as single gases, are the preferred propellants. It is permissible for the propellant to have a water content of no more than 0.2%, typically 0.1-0.2%. All percentages herein are by weight unless otherwise indicated. It is also preferable that the propellant be synthetically produced to minimize the presence of contaminants which are harmful to the active compounds. These contaminants include oxidizing agents, reducing agents, Lewis acids or bases, and water. The concentration of each of these should be less than 0.1%, except that water may be as high as 0.2%.
- Suitable non-polar solvents for the capsules and the non-polar sprays include (C2-C24) fatty acid (C2-C6) esters, C7-C18 hydrocarbon, C2-C6 alkanoyl esters, and the triglycerides of the corresponding acids. When the capsule fill is a paste, other liquid components may be used instead of the above low molecular weight solvents. These include soya oil, corn oil, other vegetable oils.
- As solvents for the polar capsules or sprays there may be used low molecular weight polyethyleneglycols (PEG) of 400-1000 Mw (preferably 400-600), low molecular weight (C2-C8) mono and polyols and alcohols of C7-C18 linear or branch chain hydrocarbons, glycerin may also be present and water may also be used in the sprays, but only in limited amount in the capsules.
- It is expected that some glycerin and water used to make the gelatin shell will migrate from the shell to the fill during the curing of the shell. Likewise, there may be some migration of components from the fill to the shell during curing and even throughout the shelf-life of the capsule.
- Therefore, the values given herein are for the compositions as prepared, it being within the scope of the invention that minor variations will occur.
- The preferred flavoring agents are synthetic or natural oil of peppermint, oil of spearmint, citrus oil, fruit flavors, sweeteners (sugars, aspartame, saccharin, etc.), and combinations thereof.
- The active substances include the active compounds selected from the group consisting of cyclosporine, sermorelin, octreotide acetate, calcitonin-salmon, insulin lispro, sumatriptan succinate, clozepine, cyclobenzaprine, dexfenfluramine hydrochloride, glyburide, zidovudine, erythromycin, ciprofloxacin, ondansetron hydrochloride, dimenhydrinate, cimetidine hydrochloride, famotidine, phenytoin sodium, phenytoin, carboprost thromethamine, carboprost, diphenhydramine hydrochloride, isoproterenol hydrochloride, terbutaline sulfate, terbutaline, theophylline, albuterol sulfate and neutraceuticals, that is to say nutrients with pharmacological action such as but not limited to camitine, valerian, echinacea, and the like.
- In another embodiment, the active compound is a nerve impulse inhibitor, anti-opioid agent, anti-migraine agent, anti-muscle spasm agent, pain control agent, anesthetic, anti-inflammatory drug, or a mixture thereof.
- In one embodiment the active compound is a nerve impulse inhibitor. Suitable nerve impulse inhibitors for use in the buccal sprays of the invention include, but are not limited to levobupivacaine, lidocaine, prilocalne, mepivacaine, propofol, rapacuronium bromide, ropivacaine, tubocurarine, atracurium, doxacurium, mivacurium, pancuronium, vecuronium, pipecuronium, rocuronium, and mixtures thereof.
- In one embodiment the active compound is an anti-opioid agent. Suitable anti-opioid agents for use in the buccal sprays of the invention include, but are not limited to, naloxone, nalmefene, naltrexone, cholecystokinin, nociceptin, neuropeptide FF, oxytocin, vasopressin, and mixtures thereof.
- In one embodiment the active compound is an anti-migraine agent. Suitable anti-migraine agents for use in the buccal sprays of the invention include, but are not limited to, frovatriptan, zolmitriptan, rizatriptan, almotriptan, eletriptan, naratriptan, almotriptan, ergotamine, diethylergotamine, sumatriptan, and mixtures thereof.
- In one embodiment the active compound is an anti-muscle spasm agent. Suitable anti-muscle spasm agents for use in the buccal sprays of the invention include, but are not limited to, baclofen, botulinum toxin, carisoprodol, chlorphenesin, chlorzoxazone, cyclobenzaprine, dantrolene, diazepam, metaxalone, methocarbamol, orphenadrine, tizanidine, and mixtures thereof.
- In one embodiment the active compound is a pain control agent. Suitable pain control agents for use in the buccal sprays of the invention include, but are not limited to, non-steroidal anti-inflammatory drugs, alfentanil, butorphanol, codeine, dezocine, fentanyl, hydrocodone, hydromorphone, levorphanol, meperidine, methadone, morphine, nalbuphine, oxycodone, oxymorphone, propoxyphene, pentazocine, sufentanil, tramadol, and mixtures thereof.
- In one embodiment the active compound is an anesthetic. Suitable anesthetics for use in the buccal sprays of the invention include, but are not limited to, benzonatate, bupivacaine, desflurane, enflurane, isoflurane, levobupivacaine, lidocaine, mepivacaine, prilocalne, propofol, rapacuronium bromide, ropivacaine, sevoflurane, ketamine, and mixtures thereof.
- In one embodiment the active compound is an anti-inflammatory drug. Suitable anti-inflammatory drugs for use in the buccal sprays of the invention include, but are not limited to, alosetron, anakinra, beclomethasone, betamethasone, budesonide, clobetasol, celecoxib, cromolyn, desoximetasone, dexamethasone, epinastic, etanercept, etoricoxib, flunisolide, fluocinonide, fluticasone, formoterol, hydrocortisone, hydroxychloroquine, ibudilast, ketotifen, meloxicam, mesalamine, methotrexate, methylprednisolone, mometasone, montelukast, nedocromil, olsalazine, prednisone, ramatroban, rofecoxib, salsalate, terbutaline, triamcinolone, valdecoxib, zafirlukast, and mixtures thereof.
- The formulations of the present invention comprise an active compound or a pharmaceutically acceptable salt thereof. The term “pharmaceutically acceptable salts” refers to salts prepared from pharmaceutically acceptable non-toxic acids or bases including organic and inorganic acids or bases.
- When an active compound of the present invention is acidic, salts may be prepared from pharmaceutically acceptable non-toxic bases. Salts derived from all stable forms of inorganic bases include aluminum, ammonium, calcium, copper, iron, lithium, magnesium, manganese, potassium, sodium, zinc, etc. Particularly preferred are the ammonium, calcium, magnesium, potassium, and sodium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion-exchange resins such as arginine, betaine, caffeine, choline, N,N dibenzylethylenediamine, diethylamine, 2-diethylaminoethanol, 2-dimethyl-aminoethanol, ethanolamine, ethylenediamine, N-ethylmorpholine, N-ethylpiperidine, glucamine, glucosamine, histidine, isopropylamine, lysine, methyl-glucosamine, morpholine, piperazine, piperidine, polyamine resins, procaine, purine, theobromine, triethylamine, trimethylamine, tripropylamine, etc.
- When an active compound of the present invention is basic, salts may be prepared from pharmaceutically acceptable non-toxic acids. Such acids include acetic, benzenesulfonic, benzoic, camphorsulfonic, citric, ethane-sulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, mandelic, methanesulfonic, mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulfuric, tartaric, p-toluenesulfonic, etc. Particularly preferred are citric, hydrobromic, maleic, phosphoric, sulfuric, and tartaric acids.
- In the discussion of methods of treatment herein, reference to the active compounds is meant to also include the pharmaceutically acceptable salts thereof. While certain formulations are set forth herein, the actual amounts to be administered to the mammal or man in need of same are to be determined by the treating physician.
- The invention is further defined by reference to the following examples, which are intended to be illustrative and not limiting.
- The following are examples of certain classes. All values unless otherwise specified are in weight percent.
- Example 1
-
A. Cyclosporine lingual spray most Amounts preferred amount preferred amount cyclosporine 5-50 10-35 15-25 water 5-20 7.5-50 9.5-12 ethanol 5-60 7.5-50 10-20 polyethylene glycol 20-60 30-45 35-40 flavors 0.1-5 1-4 2-3 -
B. Cyclosporine Non-Polar lingual spray preferred most Amounts amount preferred amount cyclosporine 1-50 3-40 5-30 Migylol 20 25 30-40 Polyoxyethylated castor oil 20 25 30-40 Butane 25-80 30-70 33-50 flavors 0.1-5 1-4 2-3 -
C. Cyclosporine non-polar bite caosule Amounts preferred amount most preferred amount cyclosporine 1-35 5-25 10-20 olive oil 25-60 35-55 30-45 polyoxyethylated 25-60 35-55 30-45 oleic glycerides flavors 0.1-5 1-4 2-3 -
D. Cyclosporine bite capsule most Amounts preferred amount preferred amount cyclosporine 5-50 10-35 15-25 polyethylene glycol 20-60 30-45 35-40 glycerin 5-30 7.5-25 10-20 propylene glycol 5-30 7.5-25 10-20 flavors 0.1-10 1-8 3-6 -
E. Sermorelin (as the acetate) lingual spray preferred Amounts amount most preferred sermorelin (as the acetate) .01-5 .1-3 .2-1.0 mannitol 1-25 5-20 10-15 monobasic sodium phosphate, 0.1-5 1-31 .5-2.5 dibasic sodium phosphate water 0.01-5 .05-3 0.1-0.5 ethanol 5-30 7.5-25 9.5-15 polyethylene glycol 20-60 30-45 35-40 propylene glycol 5-25 10-20 12-17 flavors 0.1-5 1-4 2-3 -
F. Octreotide acetate (Sandostatin) lingual spray most Amounts preferred amount preferred amount octreotide acetate 0.001-0.5 0.005-0.250 0.01-0.10 acetic acid 1-10 2-8 4-6 sodium acetate 1-10 2-8 4-6 sodium chloride 3-30 .5-25 15-20 flavors 0.1-5 0.5-.4 2-3 ethanol 5-30 7.5-20 9.5-15 water 15-95 35-90 65-85 flavors 0.1-5 1-4 2-3 -
G. Calcitonin-salmon lingual spray most Amounts preferred amount preferred amount calcitonin-salmon 0.001-5 0.005-2 01-1.5 ethanol 2-15 3-10 7-9.5 water 30-95 50-90 60-80 polyethylene glycol 2-15 3-10 7-9.5 sodium chloride 2.5-20 5-15 10-12.5 flavors 0.1-5 1-4 2-3 -
H. Insulin lispro, lingual spray most preferred Amounts preferred amount amount insulin 20-60 4-55 5-50 glycerin 0.1-10 0.25-5 0.1-1.5 dibasic sodium 1-15 2.5-10 4-8 phosphate m-cresol, 1-25 5-25 7.5-12.5 zinc oxide 0.01-0.25 .05-0.15 0.075-0.10 m-cresol 0.1-1 0.2-0.8 0.4-0.6 phenol trace amounts trace amounts trace amounts ethanol 5-20 7.5-15 9-12 water 30-90 40-80 50-75 propylene glycol 5-20 7.5-15 9-12 flavors 0.1-5 0.5-3 0.75-2 - CNS active amines and their salts: including but not limited to tricyclic amines, GABA analogues, thiazides, phenothiazine derivatives, serotonin antagonists and serotonin reuptake inhibitors
A. Sumatriptan succinate lingual spray most Amounts preferred amount preferred amount sumatriptan succinate 0.5-30 1-20 10-15 ethanol 5-60 7.5-50 10-20 propylene glycol 5-30 7.5-20 10-15 polyethylene glycol 0-60 30-45 35-40 water 5-30 7.5-20 10-15 flavors 0.1-5 1-4 2-3 -
B. Sumatriptan succinate bite capsule most Amounts preferred amount preferred amount sumatriptan succinate 0.01-5 0.05-3.5 0.075-1.75 polyethylene glycol 25-70 30-60 35-50 glycerin 25-70 30-60 35-50 flavors 0.1-10 1-8 3-6 -
C. Clozepine lingual spray most Amounts preferred amount preferred amount clozepine 0.5-30 1-20 10-15 ethanol 5-60 7.5-50 10-20 propylene glycol 5-30 7.5-20 10-15 polyethylene glycol 0-60 30-45 35-40 water 5-30 7.5-20 10-15 flavors 0.1-5 1-4 2-3 -
D. Clozepine non-polar lingual spray with propellant Amounts preferred amount most preferred amount clozepine 0.5-30 1-20 10-15 Migylol 20-85 25-70 30-40 Butanol 5-80 30-75 60-70 flavors 0.1-5 1-4 2-3 -
E. Clozepine non-polar lingual spray without propellant Amounts preferred amount most preferred amount clozepine 0.5-30 1-20 10-15 Migylol 70-99.5 80-99 85-90 flavors 0.1-5 1-4 2-3 -
F. Cyclobenzaprine non-polar lingual spray Amounts preferred amount most preferred amount cyclobenzaprine 0.5-30 1-20 10-15 (base) Migylol 20-85 25-70 30-40 Iso-butane 15-80 30-75 60-70 flavors 0.1-5 1-4 2-3 -
G. Dexfenfluramine hydrochloride lingual spray most Amounts preferred amount preferred amount dexfenfluramine Hcl 5-30 7.5-20 10-15 ethanol 5-60 7.5-50 10-20 propylene glycol 5-30 7.5-20 10-15 polyethylene glycol 0-60 30-45 35-40 water 5-30 7.5-20 10-15 flavors 0.1-5 1-4 2-3 -
A. Glyburide lingual spray most Amounts preferred amount preferred amount glyburide 0.25-25 0.5-20 0.75-15 ethanol 5-60 −7.5-50 10-20 propylene glycol 5-30 7.5-20 10-15 polyethylene glycol 0-60 30-45 35-40 water 2.5-30 5-20 6-15 flavors 0.1-5 1-4 2-3 -
B. Glyburide non-polar bite capsule most Amounts preferred amount preferred amount glyburide 0.01-10 0.025-7.5 0.1-4 olive oil 30-60 35-55 30-50 polyoxyethylated oleic 30-60 35-55 30-50 glycerides flavors 0.1-5 1-4 2-3 -
A. Zidovudine [formerly called azidothymidine (AZT) (Retrovir)] non-polar lingual spray Amounts preferred amount most preferred amount zidovudine 10-50 15-40 25-35 Soya oil 20-85 25-70 30-40 Butane 15-80 30-75 60-70 flavors 0.1-5 1-4 2-3 -
B. Erythromycin bite capsule bite capsule most preferred Amounts preferred amount amount erythromycin 25-65 30-50 35-45 polyoxyethylene glycol 5-70 30-60 45-55 glycerin 5-20 7.5-15 10-12.5 flavors 1-10 2-8 3-6 -
C. Ciprofloxacin hydrochloride bite capsule preferred most preferred Amounts amount amount ciprofloxacin hydrochloride 25-65 35-55 40-50 glycerin 5-20 7.5-15 10-12.5 polyethylene glycol 120-75 30-65 40-60 flavors 1-10 2-8 3-6 -
D. zidovudine [formerly called azidothymidine (AZT) (Retrovir)] lingual spray most preferred Amounts preferred amount amount zidovudine 10-50 15-40 25-35 water 30-80 40-75 45-70 ethanol 5-20 7.5-15 9.5-12.5 polyethylene glycol 5-20 7.5-15 9.5-12.5 flavors 0.1-5 1-4 2-3 - Anti-Emetics
A. Ondansetron hydrochloride lingual spray preferred most preferred Amounts amount amount ondansetron hydrochloride 1-25 2-20 2.5-15 citric acid monohydrate 1-10 2-8 2.5-5 sodium citrate dihydrate 0.5-5 1-4 1.25-2.5 water 1-90 5-85 10-75 ethanol 5-30 7.5-20 9.5-15 propylene glycol 5-30 7.5-20 9.5-15 polyethylene glycol 5-30 7.5-20 9.5-15 flavors 1-10 3-8 5-7.5 -
B. Dimenhydrinate bite capsule most Amounts preferred amount preferred amount dimenhydrinate 0.5-30 2-25 3-15 glycerin 5-20 7.5-15 10-12.5 polyethylene glycol 45-95 50-90 55-85 flavors 1-10 2-8 3-6 -
C. Dimenhydrinate polar lingual spray most Amounts preferred amount preferred amount dimenhydrinate 3-50 4-40 5-35 water 5-90 10-80 15-75 ethanol 1-80 3-50 5-10 polyethylene glycol 1-80 3-50 5-15 sorbitol 0.1-5 0.2-40 0.4-1.0 aspartame 0.01-0.5 0.02-0.4 0.04-0.1 flavors 0.1-5 1-4 2-3 - Histamine H-2 Receptor Antagonists
A. Cimetidine hydrochloride bite capsule most Amounts preferred amount preferred amount cimetidine HCl 10-60 15-55 25-50 glycerin 5-20 7.5-15 10-12.5 polyethylene glycol 20-90 25-85 30-75 flavors 1-10 2-8 3-6 -
B. Famotidine lingual spray most Amounts preferred amount preferred amount famotidine 1-35 5-30 7-20 water 2.5-25 3-20 5-10 L-aspartic acid 0.1-20 1-15 5-10 polyethylene glycol 20-97 30-95 50-85 flavors 0.1-10 1-7.5 2-5 -
C. Famotidine non-polar lingual spray Amounts preferred amount most preferred amount famotidine 1-35 5-30 7-20 Soya oil 10-50 15-40 15-20 Butane 1 5-80 30-75 45-70 polyoxyethylated 10-50 15-40 15-20 oleic glycerides flavors 0.1-5 1-4 2-3 -
A. Phenytoin sodium lingual spray most Amounts preferred amount preferred amount phenytoin sodium 10-60 15-55 20-40 water 2.5-25 3-20 5-10 ethanol 5-30 7.5-20 9.5-15 propylene glycol 5-30 7.5-20 9.5-15 polyethylene glycol 5-30 7.5-20 9.5-15 flavors 1-10 3-8 5-7.5 -
B. Phenytoin non-polar lingual spray most preferred Amounts preferred amount amount phenytoin 5-45 10-40 15-35 migylol 10-50 15-40 15-20 Butane 15-80 30-75 60-70 polyoxyethylated 10-50 15-40 15-20 oleic glycerides flavors 0.1-10 1-8 5-7.5 -
A. Carboprost thromethamine lingual spray preferred most preferred Amounts amount amount carboprost thromethamine 0.05-5 0.1-3 0.25-2.5 water 50-95 60-80 65-75 ethanol 5-20 7.5-15 9.5-12.5 polyethylene glycol 5-20 7.5-15 9.5-12.5 sodium chloride 1-20 3-15 4-8 flavors 0.1-5 1-4 2-3 - pH is adjusted with sodium hydroxide and/or hydrochloric acid
B. Carboprost non-polar lingual spray Amounts preferred amount most preferred amount carboprost 0.05-5 0.1-3 0.25-2.5 migylol 25-50 30-45 35-40 Butane 5-60 10-50 20-35 polyoxyethylated 25-50 30-45 35-40 oleic glycerides flavors 0.1-10 1-8 5-7.5 -
A. Carnitine as bite capsule (contents are a paste) Amounts preferred amount most preferred amount carnitine 6-80 30-70 45-65 fumarate soya oil 7.5-50 10-40 12.5-35 soya lecithin 0.001-1.0 0.005-0.5 .01-0.1 Soya fats 7.5-50 10-40 12.5-35 flavors 1-10 2-8 3-6 -
B. Valerian as lingual spray Amounts preferred amount most preferred amount valerian extract 0.1-10 0.2-7 0.25-5 water 50-95 60-80 65-75 ethanol 5-20 7.5-15 9.5-12.5 polyethylene 5-20 7.5-15 9.5-12.5 glycol flavors 1-10 2-8 3-6 -
C. Echinacea as bite capsule Amounts preferred amount most preferred amount echinacea 30-85 40-75 45-55 extract soya oil 7.5-50 10-40 12.5-35 soya lecithin 0.001-1.0 0.005-0.5 .01-0.1 Soya fats 7.5-50 10-40 12.5-35 flavors 1-10 2-8 3-6 -
D. Mixtures of ingredients Amounts preferred amount most preferred amount magnesium oxide 15-40 20-35 25-30 chromium 0.01-1.0 0.02-0.5 .025-0.75 picolinate folic acid .025-3.0 0.05-2.0 0.25-0.5 vitamin B-12 0.01-1.0 0.02-0.5 .025-0.75 vitamin E 15-40 20-35 25-30 Soya oil 10-40 12.5-35 15-20 soya lecithin 0.1-5 0.2-4 0.5-1.5 soya fat 10-40 15-35 17.5-20 -
A. Diphenhydramine hydrochloride lingual spray Amounts preferred amount most preferred amount diphenhydramine 3-50. 4-40 5-35 HCl water 5-90 10-80 50-75 ethanol 1-80 3-50 5-10 polyethylene 1-80 3-50 5-15 glycol Sorbitol 0.1-5 0.2-4 0.4-1.0 aspartame 0.01-0.5 0.02-0.4 0.04-0.1 flavors 0.1-5 1-4 2-3 -
A. Isoproterenol Hydrochloride as polar lingual spray Amounts preferred amount most preferred amount isoproterenol 0.1-10 0.2-7.5 0.5-6 Hydrochloride water 5-90 10-80 50-75 ethanol 1-80 3-50 5-10 polyethylene 1-80 3-50 5-15 glycol Sorbitol 0.1-5 0.2-4 0.4-1.0 aspartame 0.01-0.5 0.02-0.4 0.04-0.1 flavors 0.1-5 1-4 2-3 -
B. Terbutaline sulfate as polar lingual spray Amounts preferred amount most preferred amount terbutaline sulfate 0.1-10 0.2-7.5 0.5-6 water 5-90 10-80 50-75 ethanol 1-10 2-8 2.5-5 Sorbitol 0.1-5 0.2-4 0.4-1.0 aspartame 0.01-0.5 0.02-0.4 0.04-0.1 flavors 0.1-5 1-4 2-3 -
C. Terbutaline as non-polar lingual spray Amounts preferred amount most preferred amount terbutaline 0.1-10 0.2-7.5 0.5-6 migylol 25-50 30-45 35-40 isobutane 5-60 10-50 20-35 polyoxyethylated 25-50 30-45 35-40 oleic glycerides flavors 0.1-10 1-8 5-7.5 -
D. Theophylline polar bite capsule Amounts preferred amount most preferred amount theophylline 5-50 10-40 15-30 polyethylene 20-60 25-50 30-40 glycol glycerin 25-50 35-45 30-40 propylene glycol 25-50 35-45 30-40 flavors 0.1-5 1-4 2-3 -
E. Albuterol sulfate as polar lingual spray preferred most preferred Amounts amount amount albuterol sulfate 0.1-10 0.2-7.5 0.5-6 water 5-90 10-80 50-75 ethanol 1-10 2-8 2.5-5 Sorbitol 0.1-5 0.2-4 0.4-1.0 aspartame 0.01-0.5 0.02-0.4 0.04-0.1 flavors 0.1-5 1-4 2-3 - Polar Solvent Formulations Using a Propellant:
A. Sulfonylurea Preferred Most-Preferred Amount Amount Amount glyburide 0.1-25% 0.5-15% 0.6-10% Ethanol 40-99% 60-97% 70-97% Water 0.01-5% 0.1-4% 0.2-2% Flavors 0.05-10% 0.1-5% 0.1-2.5% Propellant 2-10% 3-5% 3-4% -
B. Prostaglandin E (vasodilator) Preferred Most-Preferred Amount Amount Amount prostaglandin E1 0.01-10% 0.1-5% 0.2-3% Ethanol 10-90% 20-75% 25-50% Propylene glycol 1-90% 5-80% 10-75% Water 0.01-5% 0.1-4% 0.2-2% Flavors 0.05-10% 0.1-5% 0.1-2.5% Propellant 2-10% 3-5% 3-4% -
C. Promethazine (antiemetic, sleep inducer, and CNS active amine) Preferred Most-Preferred Amount Amount Amount promethazine 1-25% 3-15% 5-12% Ethanol 10-90% 20-75% 25-50% Propylene glycol 1-90% 5-80% 10-75% Water 0.01-5% 0.1-4% 0.2-2% Flavors 0.05-10% 0.1-5% 0.1-2.5% Propellant 2-10% 3-5% 3-4% -
D. Meclizine Preferred Most-Preferred Amount Amount Amount meclizine 1-25% 3-15% 5-12% Ethanol 1-15% 2-10% 3-6 Propylene glycol 20-98% 5-90% 10-85% Water 0.01-5% 0.1-4% 0.2-2% Flavors 0.05-10% 0.1-5% 0.1-2.5% Propellant 2-10% 3-5% 3-4%
Claims (55)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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US10/726,625 US6969508B2 (en) | 1997-10-01 | 2003-12-04 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
US11/211,487 US20050287075A1 (en) | 1997-10-01 | 2005-08-26 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1997/017899 WO1999016417A1 (en) | 1997-10-01 | 1997-10-01 | Buccal, polar and non-polar spray or capsule |
US53711800A | 2000-03-29 | 2000-03-29 | |
US10/230,059 US20030185761A1 (en) | 1997-10-01 | 2002-08-29 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
US10/726,625 US6969508B2 (en) | 1997-10-01 | 2003-12-04 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
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US53711800A Continuation-In-Part | 1997-10-01 | 2000-03-29 | |
US10/230,059 Division US20030185761A1 (en) | 1997-10-01 | 2002-08-29 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
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Application Number | Title | Priority Date | Filing Date |
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US11/211,487 Continuation US20050287075A1 (en) | 1997-10-01 | 2005-08-26 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
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Publication Number | Publication Date |
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US20040120896A1 true US20040120896A1 (en) | 2004-06-24 |
US6969508B2 US6969508B2 (en) | 2005-11-29 |
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Application Number | Title | Priority Date | Filing Date |
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US10/230,059 Abandoned US20030185761A1 (en) | 1997-10-01 | 2002-08-29 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
US10/726,625 Expired - Fee Related US6969508B2 (en) | 1997-10-01 | 2003-12-04 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
US12/351,606 Abandoned US20090124554A1 (en) | 1997-10-01 | 2009-01-09 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
US13/467,441 Abandoned US20120252846A1 (en) | 1997-10-01 | 2012-05-09 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
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Application Number | Title | Priority Date | Filing Date |
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US10/230,059 Abandoned US20030185761A1 (en) | 1997-10-01 | 2002-08-29 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
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Application Number | Title | Priority Date | Filing Date |
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US12/351,606 Abandoned US20090124554A1 (en) | 1997-10-01 | 2009-01-09 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
US13/467,441 Abandoned US20120252846A1 (en) | 1997-10-01 | 2012-05-09 | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
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US (4) | US20030185761A1 (en) |
EP (1) | EP1539107A2 (en) |
JP (1) | JP2006505611A (en) |
AU (1) | AU2003296899A1 (en) |
CA (1) | CA2497268A1 (en) |
NZ (1) | NZ539284A (en) |
WO (1) | WO2004043428A2 (en) |
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US20030077227A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
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US20040136915A1 (en) * | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing atropine |
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US20050226925A1 (en) * | 2004-02-17 | 2005-10-13 | Transoral Pharmaceuticals, Inc. | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
US20050281752A1 (en) * | 1997-10-01 | 2005-12-22 | Dugger Harry A Iii | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
US20050287075A1 (en) * | 1997-10-01 | 2005-12-29 | Dugger Harry A Iii | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
US20060062812A1 (en) * | 2003-03-11 | 2006-03-23 | Calvin Ross | Novel compositions |
US20060159624A1 (en) * | 1997-10-01 | 2006-07-20 | Dugger Harry A Iii | Buccal, polar and non-polar spray containing zolpidem |
US20060198790A1 (en) * | 1997-10-01 | 2006-09-07 | Dugger Harry A Iii | Buccal, polar and non-polar spray containing ondansetron |
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US20070260491A1 (en) * | 2006-05-08 | 2007-11-08 | Pamela Palmer | System for delivery and monitoring of administration of controlled substances |
US20070299687A1 (en) * | 2006-06-23 | 2007-12-27 | Pamela Palmer | Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed |
US20080147044A1 (en) * | 2006-01-06 | 2008-06-19 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
US20080164275A1 (en) * | 2007-01-05 | 2008-07-10 | Acelrx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
US20080171089A1 (en) * | 2006-12-22 | 2008-07-17 | Blondino Frank E | Stable anti-nausea oral spray formulations and methods |
US20080268023A1 (en) * | 2006-01-06 | 2008-10-30 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US20080280947A1 (en) * | 2007-05-10 | 2008-11-13 | Blondino Frank E | Anti-insomnia compositions and methods |
US20090107836A1 (en) * | 2007-10-30 | 2009-04-30 | Novellus Systems, Inc. | Closed Contact Electroplating Cup Assembly |
US20090131479A1 (en) * | 2006-01-06 | 2009-05-21 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage |
EP2068831A2 (en) * | 2006-07-28 | 2009-06-17 | Novadel Pharma Inc. | Anti-migraine oral spray formulations and methods |
US20090162298A1 (en) * | 1997-10-01 | 2009-06-25 | Dugger Iii Harry A | Buccal, polar and non-polar spray containing sumatriptan |
US20090162300A1 (en) * | 1997-10-01 | 2009-06-25 | Dugger Iii Harry A | Buccal, polar and non-polar spray containing alprazolam |
US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
EP2767163A1 (en) | 2005-02-17 | 2014-08-20 | Abbott Laboratories | Transmucosal administration of drug compositions for treating and preventing disorders in animals |
US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
US9629894B2 (en) | 2015-01-07 | 2017-04-25 | Trigemina, Inc. | Magnesium-containing oxytocin formulations and methods of use |
US9642996B2 (en) | 2006-01-06 | 2017-05-09 | Acelrx Pharmaceuticals, Inc. | Methods and apparatus for administering small volume oral transmucosal dosage forms |
US11058856B2 (en) | 2014-12-23 | 2021-07-13 | Acelrx Pharmaceuticals, Inc. | Systems, devices and methods for dispensing oral transmucosal dosage forms |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030095926A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract |
CA2516338A1 (en) * | 2003-03-11 | 2004-09-23 | Arakis Ltd. | Novel compositions containing fentanyl |
NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
US20060002989A1 (en) * | 2004-06-10 | 2006-01-05 | Ahmed Salah U | Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same |
WO2006093786A2 (en) * | 2005-02-25 | 2006-09-08 | University Of Kentucky Research Foundation | Scopolamine sublingual spray |
US20090117054A1 (en) * | 2005-03-29 | 2009-05-07 | University Of Kentucky Research Foundation | Sublingual spray for the treatment of pain |
US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
US20060281783A1 (en) | 2005-05-25 | 2006-12-14 | Transoral Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
SI1976521T1 (en) | 2006-01-25 | 2015-06-30 | Insys Therapeutics, Inc. | Sublingual fentanyl spray |
EP2801358A3 (en) * | 2006-05-08 | 2015-03-04 | Arturo Solis Herrera | The use of nicotine for diminishing pain in renal region in humans |
CA2663857C (en) * | 2006-09-20 | 2017-10-31 | The Board Of Regents Of The University Of Texas System | Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief |
US8653066B2 (en) | 2006-10-09 | 2014-02-18 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
NO2180844T3 (en) | 2007-08-02 | 2018-07-21 | ||
DE102007063040A1 (en) | 2007-12-28 | 2009-07-23 | Atotech Deutschland Gmbh | Production of micro-reactors comprises coating a plate having channels and joint regions on the surface with a joining layer, applying a layer made from a suspension containing catalyst support particles and further processing |
EP2240022B1 (en) | 2008-01-09 | 2016-12-28 | Charleston Laboratories, Inc. | Bilayered tablets comprising oxycodone and promethazine |
US20110159078A1 (en) * | 2008-01-22 | 2011-06-30 | Vapogenix, Inc | Volatile Anesthetic Compositions and Methods of Use |
CA2712731C (en) * | 2008-01-22 | 2016-05-03 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
EP2436383B1 (en) * | 2009-05-29 | 2017-07-19 | Morishita Jintan Co., Ltd. | Oral medicinal composition and oral medicinal capsule having the composition encapsulated therein |
WO2011006012A1 (en) | 2009-07-08 | 2011-01-13 | Charleston Laboratories Inc. | Pharmaceutical compositions |
US11337962B2 (en) | 2009-09-25 | 2022-05-24 | Upsher-Smith Laboratories, Llc | Formulations comprising triptan compounds |
MX338110B (en) * | 2009-09-25 | 2016-04-01 | Reddys Lab Ltd Dr | Formulations comprising triptan compounds. |
US8357398B2 (en) * | 2009-10-21 | 2013-01-22 | Alitair Pharmaceuticals Inc. | Benzonatate compositions and methods of use |
BR112012012945A2 (en) | 2009-11-25 | 2020-12-29 | Arisgen Sa | MUCOSAL RELEASE COMPOSITION, ITS PRODUCTION METHOD, PRE-FORMED PEPTIDE COMPLEX, KIT AND USE OF AN ACTIVE PEPTIDE AGENT |
GB2476494A (en) * | 2009-12-24 | 2011-06-29 | Norwich Pharma Technologies Ltd | Formulation for the sublingual delivery of sufentanil |
EP2526971A1 (en) | 2011-05-25 | 2012-11-28 | ArisGen SA | Mucosal delivery of drugs |
FR2994844B1 (en) * | 2012-08-31 | 2015-01-02 | Assist Publ Hopitaux De Paris | GELIFYING FORMULATION BASED ON KETAMINE |
JP6669645B2 (en) | 2013-03-15 | 2020-03-18 | ベイポジェニックス インコーポレイテッド | Novel analgesic composition |
WO2015013549A1 (en) * | 2013-07-25 | 2015-01-29 | Invado Pharmaceuticals, LLC | Treating oral inflammation, injury or pain |
AU2014306759B2 (en) | 2013-08-12 | 2018-04-26 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
CA2875384A1 (en) | 2013-12-20 | 2015-06-20 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
WO2016010771A1 (en) | 2014-07-17 | 2016-01-21 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
EP3209282A4 (en) | 2014-10-20 | 2018-05-23 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
CN105193774B (en) * | 2015-09-21 | 2018-01-16 | 山东新时代药业有限公司 | A kind of sevoflurane inhalant |
CA3055170A1 (en) | 2016-03-04 | 2017-09-08 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
US11331271B2 (en) | 2016-05-27 | 2022-05-17 | The Johns Hopkins University | Buccal, sublingual and intranasal delivery of fospropofol |
US10265309B2 (en) * | 2016-05-27 | 2019-04-23 | Insys Development Company, Inc. | Sublingual opioid formulations containing naloxone |
EP3773497B1 (en) | 2018-04-09 | 2023-10-18 | Elgan Pharma Ltd. | Oxytocin compositions and methods of use |
CN109044973A (en) * | 2018-11-02 | 2018-12-21 | 广东药科大学 | A kind of swelling and pain relieving is spraying |
CN113350277A (en) * | 2021-06-30 | 2021-09-07 | 广东科伦药业有限公司 | Mesalazine gargle for treating chemotherapy oral mucositis and preparation method thereof |
Citations (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155574A (en) * | 1962-05-24 | 1964-11-03 | Revlon | Aerosol composition |
US3304230A (en) * | 1963-02-18 | 1967-02-14 | Revlon | Liquid aerosol propellant solutions of fatty acid salts of physiologically active amines |
US3784684A (en) * | 1971-08-24 | 1974-01-08 | Bayer Ag | Coronary dilator in a pharmaceutical dosage unit form |
US4232002A (en) * | 1977-12-01 | 1980-11-04 | The Welsh National School Of Medicine | Procedures and pharmaceutical products for use in the administration of antihistamines |
US4755389A (en) * | 1985-09-11 | 1988-07-05 | Lilly Industries Limited | Chewable capsules |
US4857312A (en) * | 1985-12-18 | 1989-08-15 | Bayer Aktiengesellschaft | Dihydropyridine spray, process for its preparation and its pharmaceutical use |
US4919919A (en) * | 1987-09-30 | 1990-04-24 | Nippon Kayaku Kabushiki Kaisha | Nitroglycerin spray |
US4935243A (en) * | 1988-12-19 | 1990-06-19 | Pharmacaps, Inc. | Chewable, edible soft gelatin capsule |
US5011678A (en) * | 1989-02-01 | 1991-04-30 | California Biotechnology Inc. | Composition and method for administration of pharmaceutically active substances |
US5047230A (en) * | 1988-07-08 | 1991-09-10 | Egis Gyogyszergyar | Aerosol composition comprising nitroglycerin as active ingredient |
US5128132A (en) * | 1988-11-22 | 1992-07-07 | Parnell Pharmaceuticals, Inc. | Eriodictyon compositions and methods for treating internal mucous membranes |
US5135753A (en) * | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
US5186925A (en) * | 1990-03-10 | 1993-02-16 | G. Pohl-Boskamp Gmbh & Co. | Nitroglycerin pump spray |
US5364616A (en) * | 1992-04-15 | 1994-11-15 | The Procter & Gamble Company | Use of H-2 antagonists for treatment of gingivitis |
US5370862A (en) * | 1990-06-13 | 1994-12-06 | Schwarz Pharma Ag | Pharmaceutical hydrophilic spray containing nitroglycerin for treating angina |
US5428006A (en) * | 1990-05-10 | 1995-06-27 | Bechgaard International Research And Development A/S | Method of administering a biologically active substance |
US5457100A (en) * | 1991-12-02 | 1995-10-10 | Daniel; David G. | Method for treatment of recurrent paroxysmal neuropsychiatric |
US5456677A (en) * | 1994-08-22 | 1995-10-10 | Spector; John E. | Method for oral spray administration of caffeine |
US5474759A (en) * | 1991-06-10 | 1995-12-12 | Schering Corporation | Non-chlorofluorocarbon aerosol formulations |
US5519059A (en) * | 1994-08-17 | 1996-05-21 | Sawaya; Assad S. | Antifungal formulation |
US5593684A (en) * | 1993-08-04 | 1997-01-14 | Pharmacia Ab | Method and therapeutic system for smoking cessation |
US5605674A (en) * | 1988-12-06 | 1997-02-25 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5869082A (en) * | 1996-04-12 | 1999-02-09 | Flemington Pharmaceutical Corp. | Buccal, non-polar spray for nitroglycerin |
US5955098A (en) * | 1996-04-12 | 1999-09-21 | Flemington Pharmaceutical Corp. | Buccal non polar spray or capsule |
US5981591A (en) * | 1992-12-04 | 1999-11-09 | Mayor Pharmaceutical Laboratories, Inc. | Sprayable analgesic composition and method of use |
US6071539A (en) * | 1996-09-20 | 2000-06-06 | Ethypharm, Sa | Effervescent granules and methods for their preparation |
US6110486A (en) * | 1996-04-12 | 2000-08-29 | Flemington Pharmaceuticals Co. | Buccal polar spray or capsule |
US6458842B1 (en) * | 1994-02-01 | 2002-10-01 | Knoll Aktiengesellschaft | Liquid pharmaceutical compositions comprising thyroid hormones |
US20030211047A1 (en) * | 1997-10-01 | 2003-11-13 | Indena S.P.A. | Buccal, polar and non-polar spray or capsule |
US20040120895A1 (en) * | 1997-10-01 | 2004-06-24 | Novadel Pharma, Inc. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
Family Cites Families (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1178889A (en) | 1980-08-28 | 1984-12-04 | Kenneth S. Su | Intranasal formulation |
DE3338978A1 (en) | 1982-10-29 | 1984-05-03 | Basf Ag, 6700 Ludwigshafen | Verapamil and gallopamil and their physiologically tolerated salts for application onto the mucous membranes of the mouth, of the naso-pharyngeal space and of the rectum for absorption |
DE3246081A1 (en) | 1982-12-13 | 1984-06-14 | G. Pohl-Boskamp GmbH & Co Chemisch-pharmazeutische Fabrik, 2214 Hohenlockstedt | Nitroglycerin spray |
US4495168A (en) * | 1983-08-22 | 1985-01-22 | Basf Wyandotte Corporation | Aerosol gel |
IT1169873B (en) | 1983-10-21 | 1987-06-03 | Prodotti Formenti Srl | PHARMACEUTICAL COMPOSITION WITH SYSTEMIC ANTI-COLINESTERASIC, AGONISTIC-COLINERGIC AND ANTI-MUSCARINIC ACTIVITY |
GB8501015D0 (en) * | 1985-01-16 | 1985-02-20 | Riker Laboratories Inc | Drug |
DE3522550A1 (en) * | 1985-06-24 | 1987-01-02 | Klinge Co Chem Pharm Fab | SPRAYABLE PHARMACEUTICAL PREPARATION FOR TOPICAL APPLICATION |
EP0213108A3 (en) | 1985-06-26 | 1987-07-15 | Kurt Dr. Burghart | Pharmaceutical preparation containing an antihypotonic as the active agent |
US4689233A (en) | 1986-01-06 | 1987-08-25 | Siegfried Aktiengesellschaft | Coronary therapeutic agent in the form of soft gelatin capsules |
EP0259383B1 (en) * | 1986-03-10 | 1991-01-23 | Kurt Dr. Burghart | Pharmaceutical preparation and process for preparing the same |
US4863970A (en) * | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
DE3738236A1 (en) | 1987-11-11 | 1989-05-24 | Euro Celtique Sa | BIT CAPSULE |
WO1989010745A1 (en) | 1988-05-02 | 1989-11-16 | Pomerantz, Edwin | Compositions and in situ methods for forming films on body tissue |
US5766573A (en) | 1988-12-06 | 1998-06-16 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
DE3907414A1 (en) | 1989-03-08 | 1990-09-13 | Hoechst Ag | THE APPLICATION OF INHALED LOOP DIURETICS FOR THE TREATMENT OF ALLERGEN-INDUCED NASAL REACTIONS |
DE4000770A1 (en) | 1990-01-12 | 1991-07-18 | Reynolds Aluminium Deutschland | CONNECTION OF THE JOINT BETWEEN BAR AND POST ON A CARRIER FOR ONE OR ON A FAÇADE WALL |
US5240932A (en) * | 1990-03-30 | 1993-08-31 | Yasunori Morimoto | Percutaneously absorbable compositions of morphine or analogous analgesics of morphine |
US5143731A (en) * | 1990-08-07 | 1992-09-01 | Mediventures Incorporated | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
DE4026072A1 (en) | 1990-08-17 | 1992-02-20 | Sanol Arznei Schwarz Gmbh | NITROGLYCER-CONTAINING, HYDROPHILIC, WAESSRING PUMPSPRAY |
US5166145A (en) * | 1990-09-10 | 1992-11-24 | Alza Corporation | Antiemetic therapy |
DE4038203A1 (en) | 1990-11-30 | 1992-06-04 | Kali Chemie Pharma Gmbh | Pharmaceutical spray-prepn. for admin. of nitrate(s) - esp. for treatment of cardiovascular, disorders, asthma, migraine and colic |
EP0504112A3 (en) | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
DE4112303A1 (en) | 1991-04-15 | 1992-10-22 | Minnesota Mining & Mfg | Nitroglycerin, propellant gas-free spray prepn. - stored in container in which the steel parts are made of V4A series steels to inhibit nitroglycerin decomposition |
ES2181673T3 (en) * | 1991-05-01 | 2003-03-01 | Jackson H M Found Military Med | PROCESS OF TREATMENT OF INFECTIOUS RESPIRATORY DISEASES. |
GB9118830D0 (en) | 1991-09-03 | 1991-10-16 | Minnesota Mining & Mfg | Medical aerosol formulations |
DE4132176C2 (en) | 1991-09-27 | 1997-03-13 | Ig Spruehtechnik Gmbh | Metered aerosols with isobutane as propellant |
US5824307A (en) * | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
JP3661131B2 (en) | 1992-02-20 | 2005-06-15 | アスペン ファーマケア ヨーロッパ リミテッド | Smoking suppression device |
DK0679088T3 (en) * | 1992-09-29 | 2002-10-28 | Inhale Therapeutic Syst | Pulmonary delivery of active fragments of parathyroid hormone |
DE69230151T2 (en) | 1992-12-04 | 2000-03-09 | Mayor Pharma Lab Inc | SPRAYABLE ANALGETIC COMPOSITION AND METHOD FOR IRAL USE |
ES2122261T3 (en) * | 1993-03-17 | 1998-12-16 | Minnesota Mining & Mfg | AEROSOL FORMULATION CONTAINING A DISPERSION ADJUVANT DERIVED FROM AN ESTER, AMIDA OR MERCAPTOESTER. |
US5502076A (en) * | 1994-03-08 | 1996-03-26 | Hoffmann-La Roche Inc. | Dispersing agents for use with hydrofluoroalkane propellants |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
JP3911290B2 (en) * | 1994-05-13 | 2007-05-09 | アラダイム コーポレーション | Anesthesia prescription with aerosol |
NZ280610A (en) | 1994-12-29 | 1997-08-22 | Mcneil Ppc Inc | Soft gelatin-like pharmaceutical carrier: gelled polyethylene glycol and dispersed active agent |
US5563177A (en) * | 1995-01-30 | 1996-10-08 | American Home Products Corporation | Taste masking guaifenesin containing liquids |
US5908611A (en) * | 1995-05-05 | 1999-06-01 | The Scripps Research Institute | Treatment of viscous mucous-associated diseases |
US5635161A (en) * | 1995-06-07 | 1997-06-03 | Abbott Laboratories | Aerosol drug formulations containing vegetable oils |
US6258032B1 (en) * | 1997-01-29 | 2001-07-10 | William M. Hammesfahr | Method of diagnosis and treatment and related compositions and apparatus |
AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
US6271240B1 (en) * | 1996-05-06 | 2001-08-07 | David Lew Simon | Methods for improved regulation of endogenous dopamine in prolonged treatment of opioid addicted individuals |
US5891465A (en) * | 1996-05-14 | 1999-04-06 | Biozone Laboratories, Inc. | Delivery of biologically active material in a liposomal formulation for administration into the mouth |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
US5976573A (en) * | 1996-07-03 | 1999-11-02 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
ZA9711732B (en) | 1996-12-31 | 1998-12-28 | Quadrant Holdings Cambridge | Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery |
US5906811A (en) * | 1997-06-27 | 1999-05-25 | Thione International, Inc. | Intra-oral antioxidant preparations |
US20040136915A1 (en) * | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing atropine |
US20040141923A1 (en) * | 1997-10-01 | 2004-07-22 | Dugger Harry A. | Buccal, polar and non-polar spray containing alprazolam |
US20030190286A1 (en) * | 1997-10-01 | 2003-10-09 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating allergies or asthma |
US7632517B2 (en) * | 1997-10-01 | 2009-12-15 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
US20030095927A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders |
US20050163719A1 (en) * | 1997-10-01 | 2005-07-28 | Dugger Harry A.Iii | Buccal, polar and non-polar spray containing diazepam |
US20030095926A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract |
US20090162300A1 (en) * | 1997-10-01 | 2009-06-25 | Dugger Iii Harry A | Buccal, polar and non-polar spray containing alprazolam |
US20030077228A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating endocrine disorders |
US20040136914A1 (en) * | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing ondansetron |
US20030077229A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
US20040136913A1 (en) * | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing sumatriptan |
US20030082107A1 (en) * | 1997-10-01 | 2003-05-01 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer |
US20050002867A1 (en) * | 1997-10-01 | 2005-01-06 | Novadel Pharma Inc. | Buccal, polar and non-polar sprays containing propofol |
US20050281752A1 (en) * | 1997-10-01 | 2005-12-22 | Dugger Harry A Iii | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
US20030095925A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders |
US20030185761A1 (en) * | 1997-10-01 | 2003-10-02 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
US20050180923A1 (en) * | 1997-10-01 | 2005-08-18 | Dugger Harry A.Iii | Buccal, polar and non-polar spray containing testosterone |
US20050287075A1 (en) * | 1997-10-01 | 2005-12-29 | Dugger Harry A Iii | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
US6212227B1 (en) * | 1997-12-02 | 2001-04-03 | Conexant Systems, Inc. | Constant envelope modulation for splitterless DSL transmission |
AU766703B2 (en) | 1998-11-12 | 2003-10-23 | Frank G Pilkiewicz | An inhalation system |
US6375975B1 (en) * | 1998-12-21 | 2002-04-23 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary application |
GB9908921D0 (en) * | 1999-04-19 | 1999-06-16 | Britannia Pharmaceuticals Ltd | Spray dispenser for opiod antagonists |
JP3127918B1 (en) * | 1999-07-14 | 2001-01-29 | 住友電気工業株式会社 | Road-to-vehicle communication system, roadside communication station and on-vehicle mobile station |
CO5271697A1 (en) * | 2000-01-12 | 2003-04-30 | Pfizer Prod Inc | COMPOSITIONS AND PROCEDURES FOR THE TREATMENT OF AFFECTIONS THAT RESPOND TO AN INCREASE OF TESTOSTERONE |
CA2402020C (en) | 2000-03-09 | 2006-08-29 | Gw Pharma Limited | Pharmaceutical compositions |
CA2401424C (en) * | 2000-03-28 | 2011-02-08 | Farmarc Nederland Bv | Alprazolam inclusion complexes and pharmaceutical compositions thereof |
AU3664102A (en) * | 2000-12-01 | 2002-06-11 | Battelle Memorial Institute | Method for stabilizing biomolecules in liquid formulations |
WO2002094232A1 (en) | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of antidepressants through an inhalation route |
WO2002094234A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of opioids through an inhalation route |
-
2002
- 2002-08-29 US US10/230,059 patent/US20030185761A1/en not_active Abandoned
-
2003
- 2003-08-27 WO PCT/US2003/026859 patent/WO2004043428A2/en active Application Filing
- 2003-08-27 NZ NZ539284A patent/NZ539284A/en not_active IP Right Cessation
- 2003-08-27 EP EP03811212A patent/EP1539107A2/en not_active Withdrawn
- 2003-08-27 CA CA002497268A patent/CA2497268A1/en not_active Abandoned
- 2003-08-27 AU AU2003296899A patent/AU2003296899A1/en not_active Abandoned
- 2003-08-27 JP JP2004551444A patent/JP2006505611A/en active Pending
- 2003-12-04 US US10/726,625 patent/US6969508B2/en not_active Expired - Fee Related
-
2009
- 2009-01-09 US US12/351,606 patent/US20090124554A1/en not_active Abandoned
-
2012
- 2012-05-09 US US13/467,441 patent/US20120252846A1/en not_active Abandoned
Patent Citations (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155574A (en) * | 1962-05-24 | 1964-11-03 | Revlon | Aerosol composition |
US3304230A (en) * | 1963-02-18 | 1967-02-14 | Revlon | Liquid aerosol propellant solutions of fatty acid salts of physiologically active amines |
US3784684A (en) * | 1971-08-24 | 1974-01-08 | Bayer Ag | Coronary dilator in a pharmaceutical dosage unit form |
US4232002A (en) * | 1977-12-01 | 1980-11-04 | The Welsh National School Of Medicine | Procedures and pharmaceutical products for use in the administration of antihistamines |
US4755389A (en) * | 1985-09-11 | 1988-07-05 | Lilly Industries Limited | Chewable capsules |
US4857312A (en) * | 1985-12-18 | 1989-08-15 | Bayer Aktiengesellschaft | Dihydropyridine spray, process for its preparation and its pharmaceutical use |
US4919919A (en) * | 1987-09-30 | 1990-04-24 | Nippon Kayaku Kabushiki Kaisha | Nitroglycerin spray |
US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5047230A (en) * | 1988-07-08 | 1991-09-10 | Egis Gyogyszergyar | Aerosol composition comprising nitroglycerin as active ingredient |
US5128132A (en) * | 1988-11-22 | 1992-07-07 | Parnell Pharmaceuticals, Inc. | Eriodictyon compositions and methods for treating internal mucous membranes |
US5605674A (en) * | 1988-12-06 | 1997-02-25 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
US4935243A (en) * | 1988-12-19 | 1990-06-19 | Pharmacaps, Inc. | Chewable, edible soft gelatin capsule |
US5011678A (en) * | 1989-02-01 | 1991-04-30 | California Biotechnology Inc. | Composition and method for administration of pharmaceutically active substances |
US5186925A (en) * | 1990-03-10 | 1993-02-16 | G. Pohl-Boskamp Gmbh & Co. | Nitroglycerin pump spray |
US5428006A (en) * | 1990-05-10 | 1995-06-27 | Bechgaard International Research And Development A/S | Method of administering a biologically active substance |
US5370862A (en) * | 1990-06-13 | 1994-12-06 | Schwarz Pharma Ag | Pharmaceutical hydrophilic spray containing nitroglycerin for treating angina |
US5135753A (en) * | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
US5474759A (en) * | 1991-06-10 | 1995-12-12 | Schering Corporation | Non-chlorofluorocarbon aerosol formulations |
US5457100A (en) * | 1991-12-02 | 1995-10-10 | Daniel; David G. | Method for treatment of recurrent paroxysmal neuropsychiatric |
US5364616A (en) * | 1992-04-15 | 1994-11-15 | The Procter & Gamble Company | Use of H-2 antagonists for treatment of gingivitis |
US5981591A (en) * | 1992-12-04 | 1999-11-09 | Mayor Pharmaceutical Laboratories, Inc. | Sprayable analgesic composition and method of use |
US5593684A (en) * | 1993-08-04 | 1997-01-14 | Pharmacia Ab | Method and therapeutic system for smoking cessation |
US6458842B1 (en) * | 1994-02-01 | 2002-10-01 | Knoll Aktiengesellschaft | Liquid pharmaceutical compositions comprising thyroid hormones |
US6706255B2 (en) * | 1994-02-01 | 2004-03-16 | Abbott Gmbh & Co., Kg | Liquid pharmaceutical compositions comprising thyroid hormones |
US5519059A (en) * | 1994-08-17 | 1996-05-21 | Sawaya; Assad S. | Antifungal formulation |
US5456677A (en) * | 1994-08-22 | 1995-10-10 | Spector; John E. | Method for oral spray administration of caffeine |
US5869082A (en) * | 1996-04-12 | 1999-02-09 | Flemington Pharmaceutical Corp. | Buccal, non-polar spray for nitroglycerin |
US5955098A (en) * | 1996-04-12 | 1999-09-21 | Flemington Pharmaceutical Corp. | Buccal non polar spray or capsule |
US6110486A (en) * | 1996-04-12 | 2000-08-29 | Flemington Pharmaceuticals Co. | Buccal polar spray or capsule |
US6071539A (en) * | 1996-09-20 | 2000-06-06 | Ethypharm, Sa | Effervescent granules and methods for their preparation |
US20030211047A1 (en) * | 1997-10-01 | 2003-11-13 | Indena S.P.A. | Buccal, polar and non-polar spray or capsule |
US20040120895A1 (en) * | 1997-10-01 | 2004-06-24 | Novadel Pharma, Inc. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
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US20050226925A1 (en) * | 2004-02-17 | 2005-10-13 | Transoral Pharmaceuticals, Inc. | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
US20080008753A1 (en) * | 2004-02-17 | 2008-01-10 | Singh Nikhilesh N | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
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Also Published As
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WO2004043428A3 (en) | 2004-10-21 |
JP2006505611A (en) | 2006-02-16 |
AU2003296899A1 (en) | 2004-06-03 |
EP1539107A2 (en) | 2005-06-15 |
CA2497268A1 (en) | 2004-05-27 |
US6969508B2 (en) | 2005-11-29 |
NZ539284A (en) | 2007-07-27 |
US20120252846A1 (en) | 2012-10-04 |
US20030185761A1 (en) | 2003-10-02 |
US20090124554A1 (en) | 2009-05-14 |
WO2004043428A2 (en) | 2004-05-27 |
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