US20040044364A1 - Tissue fasteners and related deployment systems and methods - Google Patents

Tissue fasteners and related deployment systems and methods Download PDF

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Publication number
US20040044364A1
US20040044364A1 US10/230,672 US23067202A US2004044364A1 US 20040044364 A1 US20040044364 A1 US 20040044364A1 US 23067202 A US23067202 A US 23067202A US 2004044364 A1 US2004044364 A1 US 2004044364A1
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US
United States
Prior art keywords
tissue
tissue fastener
fastener
connecting member
distal
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US10/230,672
Inventor
Robert DeVries
Kristian DiMatteo
Roy Sullivan
Marc Tassy
Barry Gellman
John Hutchins
John Golden
Kurt Geitz
William Shaw
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Boston Scientific Scimed Inc
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Scimed Life Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Priority to US10/230,672 priority Critical patent/US20040044364A1/en
Assigned to SCIMED LIFE SYSTEMS, INC. reassignment SCIMED LIFE SYSTEMS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: TASSY, JR., MARC, SULLIVAN, ROY H., GOLDEN, JOHN B., GEITZ, KURT A.E., DIMATTEO, KRISTIAN, DEVRIES, ROBERT B., GELLMAN, BARRY N., HUTCHINS, JOHN E., SHAW, WILLIAM J
Priority to AT03791687T priority patent/ATE526884T1/en
Priority to JP2004532906A priority patent/JP4456482B2/en
Priority to AU2003263892A priority patent/AU2003263892A1/en
Priority to EP03791687A priority patent/EP1530442B1/en
Priority to PCT/US2003/025818 priority patent/WO2004019787A2/en
Priority to CA002463870A priority patent/CA2463870A1/en
Priority to ES03791687T priority patent/ES2369537T3/en
Publication of US20040044364A1 publication Critical patent/US20040044364A1/en
Assigned to BOSTON SCIENTIFIC SCIMED, INC. reassignment BOSTON SCIENTIFIC SCIMED, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: SCIMED LIFE SYSTEMS, INC.
Priority to US12/379,252 priority patent/US8579935B2/en
Priority to US14/043,255 priority patent/US20140031841A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • A61B17/0644Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/068Surgical staplers, e.g. containing multiple staples or clamps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00867Material properties shape memory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/044Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors with a threaded shaft, e.g. screws
    • A61B2017/0443Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors with a threaded shaft, e.g. screws the shaft being resilient and having a coiled or helical shape in the released state
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • A61B2017/0641Surgical staples, i.e. penetrating the tissue having at least three legs as part of one single body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • A61B2017/0647Surgical staples, i.e. penetrating the tissue having one single leg, e.g. tacks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • A61B2017/0649Coils or spirals

Definitions

  • the present invention relates to surgical tissue fasteners and related deployment systems and methods for delivering the tissue fasteners.
  • the present invention relates to tissue fasteners used in, for example, a fundoplication procedure for treatment of Gastroesophageal Reflux Disease (GERD).
  • GSD Gastroesophageal Reflux Disease
  • Gastroesophageal reflux occurs when stomach acid enters the esophagus. This reflux of acid into the esophagus occurs naturally in healthy individuals, but also may become a pathological condition in others. Effects from gastroesophageal reflux range from mild to severe. Mild effects include heartburn, a burning sensation experienced behind the breastbone. More severe effects include a variety of complications, such as esophageal erosion, esophageal ulcers, esophageal stricture, abnormal epithelium (e.g., Barrett's esophagus), and/or pulmonary aspiration. These various clinical conditions and changes in tissue structure that result from reflux of stomach acid into the esophagus are referred to generally as Gastroesophageal Reflux Disease (GERD).
  • GSD Gastroesophageal Reflux Disease
  • the LES 2 is a ring of smooth muscle and increased annular thickness existing in approximately the last four centimeters of the esophagus.
  • the LES creates a region of high pressure (approximately 15-30 mm Hg above intragastric pressure) at the opening of the esophagus 3 into the stomach 7 . This pressure essentially closes the esophagus 3 so that contents of the stomach cannot pass back into the esophagus 3 .
  • the LES 2 opens in response to swallowing and peristaltic motion in the esophagus 3 , allowing food to pass into the stomach. After opening, however, a properly functioning LES 2 should return to the resting, or closed state. Transient relaxations of the LES 2 do occur in healthy individuals, typically resulting in occasional bouts of heartburn.
  • the physical interaction occurring between the gastric fundus 5 and the esophagus 3 also prevents gastroesophageal reflux.
  • the gastric fundus 5 is a lobe of the stomach situated at the top of the stomach 7 distal to the esophagus 3 .
  • the fundus 5 presses against the opening of the esophagus 3 when the stomach 7 is full of food and/or gas. This effectively closes off the esophageal opening to the stomach 7 and helps to prevent acid reflux back into the esophagus 3 .
  • the food bolus As the food bolus is immersed in gastric acid, it releases gas which causes the fundus 5 of the stomach 7 to expand and thereby exert pressure on the distal esophagus 3 causing it to collapse.
  • the collapse of the esophagus lumen reduces the space for the stomach acid to splash past the closed esophagus lumen and thereby protect the proximal esophagus from its destructive contact.
  • the LES 2 functions abnormally, either due to an increase in transient LES relaxations, decreased muscle tone of the LES 2 during resting, or an inability of the esophageal tissue to resist injury or repair itself after injury. These conditions often are exacerbated by overeating, intake of caffeine, chocolate or fatty foods, smoking, and/or hiatal hernia. Avoiding these exacerbating mechanisms helps curb the negative side effects associated with GERD, but does not change the underlying disease mechanism.
  • a surgical procedure known generally as fundoplication, has been developed to prevent acid reflux in patients whose normal LES functioning has been impaired, either as a result of GERD or other adverse effects.
  • This procedure involves bringing the fundus wall 6 into closer proximity of the esophageal wall 4 to help close off the esophageal opening into the stomach 7 .
  • this procedure has been performed as an open surgery, but also has been performed laparoscopically.
  • a laparoscopic procedure may involve performing laparotomies for trocar ports (penetrations of the abdominal wall), percutaneous endoscopic gastronomies (incisions through the skin into the stomach), and the installation of ports through which, for example, a stapler, an endoscope, and an esophageal manipulator (invagination device) are inserted. Under view of the endoscope, the esophageal manipulator is used to pull the interior of the esophagus 3 into the stomach 7 .
  • the stapler When the esophagus is in position, with the fundus 5 of the stomach plicated, the stapler is moved into position around the lower end of the esophagus and the plicated fundus is stapled to the esophagus 3 .
  • the process may be repeated at different axial and rotary positions until the desired fundoplication is achieved.
  • This procedure is still relatively invasive requiring incisions through the stomach, which has a risk of infection.
  • the location of the incision in the abdominal wall presents a risk of other negative effects, such as sepsis, which can be caused by leakage of septic fluid contained in the stomach.
  • one embodiment of the present invention provides less invasive devices and methods for performing the fundoplication procedure. This is achieved by utilizing tissue fasteners and related deployment systems which can be endoluminally delivered through the esophagus 3 , thereby eliminating the need for highly invasive, physiologically insulting surgical procedures.
  • tissue fastener used to join multiple tissue layers.
  • the tissue fastener includes a proximal member configured to expand from a delivered state to a deployed state, a distal member configured to expand from a delivered state to a deployed state, and a connecting member connecting the proximal member to the distal member. In the deployed state, the proximal member and the distal member secure the multiple tissue layers together.
  • tissue fastener used to join multiple tissue layers that includes a first member, a second member, a connecting member connecting the first member to the second member, and means for applying a substantially constant force on the tissue layers.
  • the applying means may be compressible.
  • tissue fastener used to join multiple tissue layers that includes a first member, a second member, a connecting member connecting the first member to the second member, and means for adjusting a length of the connecting member between the first and second members.
  • the adjusting means may include structure associated with the first member for releasably securing the connecting member to the first member. That structure may be configured to restrict passage of the connecting member in a direction through the first member.
  • Another aspect of the present invention is to provide a delivery system configured for deployment of an expandable tissue fastener.
  • the system includes a flexible tube configured to accommodate a tissue fastener in a contracted state, a pusher for guiding the tissue fastener along a lumen of the tube, and a grasper coupled to a distal end of the pusher and having means to grasp the tissue fastener.
  • a method of attaching a first layer of tissue to a second layer of tissue includes providing an expandable tissue fastener in a contracted state in a device, the tissue fastener having a proximal member and a distal member, inserting the device into a body passage leading to the first tissue wall, placing the device proximate a location on the first tissue layer, passing the device through the first and second tissue layers, advancing the tissue fastener toward an opening of the device, such that the distal member is completely protruded out of the device and expanded against the second tissue layer, and withdrawing the device and releasing the tissue fastener, such that the proximal member is expanded against the first tissue layer.
  • the present invention is depicted in this disclosure and is particularly suitable in the treatment of GERD, e.g., a fundoplication procedure.
  • tissue fasteners and related deployment methods and systems of the present invention can be used to treat any of a number of different disease conditions, and can be used for fastening any desired body tissues.
  • FIG. 1 is a cross-sectional view of the gastrointestinal tract in the region of the lower esophageal sphincter (LES) and the fundus of the stomach;
  • LES lower esophageal sphincter
  • FIG. 2 is a perspective view of a tissue fastener, prior to deployment into a body, according to an embodiment of the present invention
  • FIG. 2A is a perspective view of a proximal fastening member of the tissue fastener of FIG. 2, showing the proximal fastening member in a deployed state according to an embodiment of the present invention
  • FIG. 2B is a perspective view of a distal fastening member of the tissue fastener of FIG. 2 in a deployed state, according to an embodiment of the present invention
  • FIGS. 3 - 7 C are perspective views of various tissue fasteners according to various embodiments of the present invention.
  • FIGS. 7 D- 7 F are cross-sectional views of tissue fastener members according to various embodiments of the present invention.
  • FIGS. 8 A- 8 R are perspective views of various designs of tissue fastening members according to additional embodiments of the present invention.
  • FIGS. 9 A- 9 J are perspective views of various connector post designs according to still other embodiments of the present invention.
  • FIGS. 10 A- 10 SS are perspective views of fasteners according to various embodiments of the present invention.
  • FIGS. 11 A-C are perspective views of an endoluminal deployment system, illustrating various operational stages of the system for deployment of a tissue fastener, according to an embodiment of the present invention
  • FIG. 12A is a schematic illustration of the tissue fastener deployment for a tissue connection procedure, showing the deployment system of FIGS. 11 A-C containing the tissue fastener of FIG. 2 and being inserted into the lower esophagus, according to an embodiment of the present invention
  • FIG. 12B is a schematic illustration of the tissue fastener deployment, showing the deployment system penetrating the esophageal wall, according to an embodiment of the present invention
  • FIG. 13 is a schematic illustration of the tissue fastener deployment, showing the deployment system penetrating the esophageal wall and the fundus wall, according to an embodiment of the present invention
  • FIG. 14 is a schematic illustration of the tissue fastener deployment, showing the expanded distal fastener member of the tissue fastener holding the fundus wall, according to an embodiment of the present invention
  • FIG. 15 is a perspective view of a proximal fastening member of the tissue fastener of FIG. 2, viewing from inside the esophagus, after the deployment is complete, according to an embodiment of the present invention
  • FIG. 16 is a cross-sectional view of the esophageal wall and the fundus wall, with a tissue fastener in place, after the tissue connection procedure;
  • FIG. 17A is a perspective view of a deployment system, with a straight distal tip, according to another embodiment of the present invention.
  • FIG. 17B is a perspective view of a deployment system, with a curved distal tip, according to still another embodiment of the present invention.
  • FIGS. 18A and 18B are views of a deployment system respectively holding and releasing a tissue fastener member.
  • a newly developed form of fundoplication is an endoluminal procedure in which the fundus wall 6 is folded back onto the esophagus wall 4 .
  • the tissue fold formed between the esophagus 3 and the fundus 5 then is secured.
  • Endoscopic fundoplication is intended to be performed as an endoluminal procedure in which insertion of required medical instruments occurs through the esophagus 3 .
  • Such a procedure has the benefits of being less invasive, quicker, and less expensive as compared to previous techniques.
  • FIG. 2 shows an exemplary embodiment of a tissue fastener 1 for use in a fundoplication procedure.
  • the tissue fastener 1 has a distal fastening member 13 , a proximal fastening member 11 , and a connecting member 12 connecting the distal fastening member 13 and the proximal fastening member 11 to each other.
  • the distal fastening member 13 , the proximal fastening member 11 , and the connecting member 12 are formed as an integrated unit or two or more components pieced together.
  • the distal fastening member 13 includes a plurality of anchor hooks or legs 23
  • the proximal fastening member 11 includes a plurality of anchor hooks or legs 21 .
  • the plurality of anchor legs 21 , 23 are constructed to expand from a contracted state to an expanded state.
  • the tissue fastener 1 is low in profile and can be loaded into a narrow lumen of an endoluminal deployment system for deployment.
  • the plurality of anchor legs 21 , 23 are expanded outwardly to fasten multiple tissue layers together between the distal and proximal fastening members 13 , 11 , thereby enhancing the tissue connection.
  • each of the distal and proximal fastening members 11 , 13 is provided with a total of six anchor legs 21 , 23 , that are equally spaced apart.
  • the fastening members 11 , 13 can be provided with more or less number of legs 21 , 23 with different desired spacing therebetween.
  • the leading edge of the distal fastening member 13 forms a sharp point or edge 15 to assist with penetrating through the tissue layers.
  • the sharp edge 15 may be a trocar-like cutting edge to perform the perforation of the layers itself. It should also be recognized that forming such a sharp cutting edge 15 may not be necessary if an endoluminal deployment system includes a cutting edge 40 on its distal tip, as shown in FIGS. 17 A-B to be described herein.
  • FIGS. 2A and 2B show the expanded state of the proximal and distal fastening members 11 , 13 , respectively in an installed state.
  • the anchor legs 23 of the distal fastening member 13 expand outwardly to form an umbrella-shaped fastening member.
  • Sharp edge or tip 15 may be removed or made of a dissolvable, biodegradable material.
  • the anchor legs 21 of the proximal fastening member 11 expand outwardly to form a fastening member.
  • Each of the anchor legs 21 of the proximal fastening member 11 may include one or more bending portions 22 at a location along the length of the leg 21 , such that the distal portion 24 of the leg 21 extends outwardly with respect to the bending portion 22 .
  • the bending portion 22 is a relatively flexible portion of an otherwise substantially rigid leg 21 .
  • the bending portion 22 may be facilitated by removal of material or change in geometry along the leg 21 .
  • the leg 21 may further comprise a variable stiffness along the leg 21 .
  • the bending portion 22 may consist of a lower stiffness material to facilitate the bending.
  • FIGS. 3 through 7 are perspective views of various tissue fasteners in expanded states according to other embodiments of the invention.
  • the tissue fastener 101 is formed of at least two elongate members 150 , such as wires or rods, interconnected in the mid-portion by a connecting member 112 .
  • the interconnection may be made through any suitable method, such as welding, brazing, molding, a locking mechanism, etc., or members may be manufactured as an integral piece.
  • each member 150 is preferably substantially straight to promote easier insertion through the esophagus and deployment.
  • each member 150 bends outwardly, substantially perpendicular to the connecting member 112 , to form the distal and proximal fastening members 113 , 111 .
  • the ends of the proximal fastening member 111 could be rounded or otherwise protected to reduce trauma when in contact with tissue.
  • the leading edge of each member 150 may form a sharp cutting edge 115 to assist with perforating layers of tissues.
  • FIG. 3A illustrates a further embodiment of the fastener of FIG. 3 wherein the distal and proximal ends of the fastener 101 turn inwards upon deployment through tissue layers. These inward turns, or hooks 114 , would contact tissue and prevent migration of fastener 101 .
  • the tissue fastener 201 is comprised of a single wire 250 or rod. Similar to the tissue fastener 101 of FIG. 3, the wire 250 preferably forms a substantially straight wire in a contracted state. In an expanded state, shown in the figure, the wire 250 forms spiral-shaped distal and proximal fastening members 213 , 211 at both ends of the that are substantially perpendicular to the connecting member 212 .
  • the wire 250 a may also form a spring-shaped fastening member 211 a , 213 a at both ends of the wire 250 a , as shown in FIG. 4B.
  • the spring-shaped fastening members 211 a , 213 a may be substantially parallel to the connecting member 212 a .
  • the leading edge of the wire 250 may form a sharp cutting edge 215 to assist with perforating layers of tissues.
  • a wire fastener may be delivered in a straight configuration and forms into a coil that may be screwed into the tissue layers.
  • a suitable material for such fasteners is nitinol.
  • the tissue fastener 301 shown in FIG. 5A is comprised of multiple wires integrally attached to a connecting member 312 .
  • each wire 350 preferably forms a substantially straight wire and, in an expanded state, shown in the figure, the wires 350 expand outwardly to form spider-shaped distal and proximal fastening members 313 , 311 .
  • the leading edges of the wires 350 may form sharp cutting edges to assist with perforating the tissue layers, it may be most beneficial to use an endoluminal deployment system with a trocar-like cutting edge, such as the device shown in FIGS. 17 A-B, or other perforating instrument to form an opening through the tissue layers prior to the deployment of the tissue fastener 301 .
  • the fastening members 311 , 313 may include inwardly bent hooks 352 at each end portion of the wires 350 to prevent migration of the fastener once deployed onto the tissue layers.
  • the tissue fastener 401 has a similar configuration as the tissue fastener 1 shown in FIG. 2, except that the distal and proximal fastening member 413 , 411 have the same configuration, much like the fastening member 11 shown in FIG. 2.
  • the distal fastening member 413 does not include a sharp pointed edge.
  • an endoluminal deployment system with a trocar-like cutting edge e.g., a device shown in FIGS. 17 A-B
  • a trocar-like cutting edge e.g., a device shown in FIGS. 17 A-B
  • FIG. 7A shows a tissue fastener 501 , also similar to the tissue fastener 1 shown in FIG. 2 in certain respects.
  • the tissue fastener 501 has a distal fastening member 513 , a proximal fastening member 511 , and an adjustable connecting member 512 .
  • the distal fastening member 513 and the proximal fastening member 511 function in a similar manner as these corresponding structures of the tissue fastener 1 shown in FIG. 2.
  • the tissue fastener 501 includes an adjustable connecting member 512 .
  • fastening member 511 is advanced forward. This action creates a compressive force on the tissues between the fastening members 511 and 513 .
  • the connecting member 512 has an elastic compressive spring force which exerts pulling force between the distal and proximal fastening members 513 , 511 so that the fastening of the multiple tissue layers is enhanced.
  • FIGS. 7C through 7F illustrate adjustable fasteners of the present invention.
  • FIG. 7C illustrates a fastener 520 have fastening members 513 and 511 and an adjustable connecting member 521 .
  • Member 521 further includes bumps (or notches) 514 which allow fastening member 511 to ratchet forward as either member 511 is advanced or connecting member 521 is pulled taut to connect tissue layers.
  • FIGS. 7D through 7F illustrate cross-sectional views of two ratcheting systems as described. In FIG. 7D, the ratcheting action is created by virtue of flexible tabs 515 located inside fastening member 511 .
  • FIG. 7E and 7F illustrate friction based or infinite ratcheting systems wherein the interference fit of a single tab 515 of FIG. 7E or of multiple tabs 515 of FIG. 7F serve to keep connecting member 521 from slipping once fastening member 511 is advanced forward onto tissue or connecting member 521 is pulled taut. If connecting member 521 is at least partially elastic, the fastener may be self adjusting once in place or the force within the fastener upon the tissues may be controlled.
  • FIGS. 8A through 8O show various other exemplary fastening members according to various embodiments of the present invention.
  • the fastening member can be formed of a flat plate 601 of virtually any geometric shape, a semispherical domed button 602 , a flexible plate 603 , a malecot 604 , a ratchet 606 , a non-orthogonal button 607 , interconnectable multiple pieces 608 , a foldable T-shaped bar 609 , a twisted or tied coil, string, or other flexible elongate member 610 , a stent-like configuration 611 wherein the connecting member has a crimped, braided configuration, a cotterpin 612 , a rivot 613 , a V-shaped clip 614 , 615 with or without a flattened top (FIGS. 8N and 8P), a staple-like configuration (FIG. 8O), and stent-like connectors with dog
  • the malecot 604 includes a plurality of legs or rods 604 a that assume a cage-like shape when in its normal, expanded position.
  • the fastening member 606 includes at least one skirt-like or frustoconical-shaped ratchet 606 which permits movement only in one direction.
  • a non-orthogonal connection between the connecting member 650 and the fastening member 607 which may include any of the described fastening members, is provided.
  • FIG. 8D the malecot 604 includes a plurality of legs or rods 604 a that assume a cage-like shape when in its normal, expanded position.
  • the fastening member 606 includes at least one skirt-like or frustoconical-shaped ratchet 606 which permits movement only in one direction.
  • a non-orthogonal connection between the connecting member 650 and the fastening member 607 which may include any of the described fastening members, is provided.
  • FIG. 8G a non-orthogonal connection between the connecting member
  • the fastening member 608 is formed of multiple pieces that are attached through any suitable means, such as piercing members or barbs.
  • the fastening member 609 is pivotally coupled to the connecting member 650 to form a T-shaped configuration. Any conventional connecting devices and methods may be used to couple the fastening member 609 and the connecting member 650 .
  • the fastening member 610 is formed of a twisted or tied element. Preferably, the member 610 is made of a single piece and double-looped.
  • the fastening member 611 is formed of a stent-like braided configuration.
  • FIGS. 8Q and 8R illustrate stent type fasteners 660 , 670 respectively having a dogbone or flare shape at each end. These fasteners are deployed in a constricted manner and expanded or allowed to expand into a fastener comprised of a singular structure.
  • the fasteners of FIGS. 8K, 8Q, and 8 R may be constructed in any manner similar to fabricating stents as is known in the art, including but not limited to knitting, weaving, twisting, laser-cut tubes, welded wires and molding.
  • the fastening member 612 is formed of a bar or a plate, fixedly attached the connecting member by a cotterpin 612 a or a stopper.
  • the fastening member 613 is formed by attaching a rivot to the connecting member 651 .
  • the connecting member 651 includes an engagement member 653 protruding outwardly at its distal end, which engages the rivot to form the fastening member 613 .
  • the fastening member 614 is a clip having two or more legs 614 b .
  • the clip is expandable in a transverse direction, as indicated by arrows in the figure, thereby enhancing the tissue connection.
  • one or more bands or O-rings 614 a are attached to limit the expansion to a desired extent and to abut the tissue layers.
  • a plate or other flat surface 614 c may be attached to, or otherwise be integral with, the expanded clip at its distal end, as shown in FIG. 8P.
  • the fastening member 616 forms a staple-like configuration. Similar to the embodiments shown in FIGS. 3 - 5 , the wire 616 a preferably forms a substantially straight wire in a contracted state and, in an expanded state, shown in the figure, the wire 616 a expands outwardly or inwardly to form the staple-like configuration. Alternatively, an anvil can be placed behind tissue layers to bend the wires 616 a and form the staple-like configuration. It should be recognized that more than two wires can be provided. Any other suitable designs providing the similar function may be utilized. In addition, the fastener may include any combination of fastening members and connecting posts.
  • a tissue fastener 605 also may include a hollow bore 630 passing through the tissue fastener to inject a therapeutic chemical agent or an adhesion promoting substance.
  • the tissue fastener is provided with an injection port 670 to permit introduction of the therapeutic substances or the adhesion promoting substance.
  • the hollow bore 630 may be provided with a one-way valve (e.g., check valve) 672 to prevent a backflow.
  • Fastener 605 may also comprise a weep hole 660 or other means along post 662 to allow delivery of the chemical agent or adhesion promoting means between the tissue layers.
  • FIGS. 10 A through 10 OO show various other exemplary fastening members according to various embodiments of the present invention. These various embodiments, in addition to certain others described throughout this specification, adjust to varying tissue thickness so that sufficient tension, and in many embodiments substantially constant tension, is placed on the tissue to hold the tissue layers together. In many of the disclosed embodiments, such adjustment is performed by adjusting the length of the connecting member between the fastening members and/or by providing a means, in many cases associated with a fastener member, for providing a substantially constant tension on the tissue layers. Most of the embodiments shown in FIGS. 10 A- 10 OO include a pair of opposed fastener members connected by a connecting member. It is to be understood that fastener members and connecting members of any embodiment may be used in combination with fastener members and connecting members of other embodiments, as desired.
  • FIG. 10A shows a “T”-shaped tissue fastener 720 having a first fastening member 721 , a connecting member 722 , and a second fastening member 723 .
  • Member 721 may comprise any suitable biocompatible elongate member, such as a portion of hypodermic tubing.
  • Connecting member 722 may comprise suture material, wire, or any other like biocompatible material that fixedly connects to member 721 , preferably in a fashion that permits member 721 to articulate with respect to connecting member 722 for ease of delivery and to the extent needed while implanted.
  • Member 723 may comprise any bead or ball-shaped structure that permits connection to connecting member 722 .
  • Member 723 may include a slot therein permitting member 722 to slide through so that the length of member 722 between members 721 , 723 may be adjusted depending on the thickness of the connected tissue layers.
  • member 723 may be similar to a fishing weight having a slit therein to hold member 722 .
  • member 723 may be a torsion spring 723 ′ having a pair of arms. When the arms are forced open in the direction of the arrows, connecting member 722 loosens from within spring 723 ′ and spring 723 ′ can slide relative to member 722 and be cinched against the tissue layers or an additional member 721 . When the arms are released, spring 723 ′ secures member 722 in position.
  • FIGS. 10 B and 10 B′ show a tissue fastener 730 having first fastening member 721 , connecting member 722 , and a second fastening member 731 having a means for providing a substantially constant force on the tissue layers.
  • the means includes a flexible bellows-like structure.
  • the bellows of member 731 permit adjustment in the length of connecting member 722 between members 721 and 731 .
  • FIG. 10B shows the bellows of member 731 in an expanded, relaxed state. The bellows are contracted during delivery through the esophagus and to the tissue layers. Then, as shown in FIG.
  • tissue fastener 740 includes a second fastener member 741 having a spring 742 between two plate-like structures 743 , such as disks or buttons.
  • tissue fastener 743 includes a second fastener member 751 having a balloon 752 between the two structures 743 .
  • tissue fastener 800 includes a second fastener member 801 having a spring 802 .
  • One end of spring 802 connects to structure 743 and the other end of spring 802 is free and places a substantially constant force against the tissue layers.
  • Any suitable, biocompatible, compressible structure may take the place of spring 742 , balloon 752 , or spring 802 .
  • FIG. 10E shows a “double-T” shaped tissue fastener 760 that is essentially of one-piece construction.
  • Fastener 760 has two opposing fastener members 762 , each taking the form of either member 721 , member 743 , or others described throughout this specification.
  • Members 762 are connected by an elastic connecting member 761 that permits an adjustable length of member 761 between members 762 .
  • Member 761 may be made of a elastic, biocompatible material, similar to a rubber-band.
  • FIG. 10H shows a similar arrangement as FIG. 10E.
  • Fastener 790 includes opposing fastener members 762 interconnected by a bungee cord-like member 792 .
  • Member 792 may be pulled tightly (elongated) between members 762 during delivery to the tissue layers and then released so that member 792 shortens and grows in diameter. The growth in diameter may permit an interference fit between member 792 and a hole, notch, slit, or other opening within one or both of the members 762 , so that member 792 secures to members 762 .
  • FIG. 10F shows a fastener 770 having first and second fastener members 771 , 772 and a connecting member 773 .
  • Member 773 includes a plurality of beads, balls, or similar enlarged structures 774 spaced along the length of member 773 .
  • the connecting member may include a plurality of notches spaced along the length of the member. The structures may be evenly or unevenly spaced as desired.
  • the structures 774 may be used in combination with a frangible member 772 having a hole that permits structures 774 to travel through the hole to shorten the length of member 773 between members 771 , 772 .
  • additional structures 774 may be pulled through the hole in member 772 .
  • Member 772 may be constructed to include a notch therein to accommodate a structure 774 .
  • the through hole in member 772 may be constructed to permit passage of structures 774 in only one direction, i.e. away from member 771 to shorten the length of member 773 between members 771 , 772 .
  • member 771 may have a similar construction as member 772 to permit passage of structures 774 therethrough. Excess connecting member 773 may be removed by any suitable method.
  • FIG. 10G shows a fastener 780 having a fastener member 781 with a ratchet-like mechanism to permit passage of connecting member 782 therethrough in one direction (shown by arrow).
  • member 781 can move in the direction opposite the arrow to tighten fastener 780 on the tissue layers, with the ratchet-like mechanism preventing loosening of member 782 relative to member 781 .
  • FIG. 10J shows a fastener 810 having a fastener member 811 with teeth 812 to capture connecting member 813 and prevent loosening. Teeth 812 may be angled in the direction of the applied force to more strongly grasp member 813 .
  • FIG. 10K shows a fastener 820 having a fastener member 821 with a biased locking mechanism 822 .
  • the lock 822 includes a ball bearing 823 or like structure contained within a through hole or passage of member 821 , and a spring 824 biasing bearing 823 into the passage. Bearing 823 will lock connecting member 825 within the passage when member 825 is not being adjusted in length between the fastener members.
  • FIGS. 10M and 10N show a locking mechanism 840 that includes a pair of eccentric wheels 841 that rotate to lock connecting member 842 in position after member 842 is adjusted in length between fastener members, similar to eccentric wheel locking mechanisms used on sailboats.
  • Mechanism 840 may be located within one or both fastener members of a fastener.
  • FIG. 10N shows a similar arrangement, having a locking mechanism 850 with eccentric wedges used to lock connecting member 852 in position.
  • FIG. 10L shows a fastener 830 having a first fastening member 831 , a connecting member 832 , and a second connecting member 833 .
  • Member 833 has a two-piece construction that includes a disk 834 that snaps or otherwise fixedly attaches to a complementary dish-shaped head 835 . After connecting member 832 is pulled through a passage in head 835 to adjust the length of member 832 between fastener member 831 and head 835 , disk 834 is forced into and attached to head 835 , securing member 832 in position.
  • FIGS. 10O and 10P show front views of exemplary fastener members 860 and 870 respectively.
  • Member 860 includes a wedge-shaped opening 861 therein that accepts a connecting member.
  • Member 871 has a wedge-shaped notch 871 in its side also for accommodating a connecting member. After being pulled taut within tissue and between fastener members, a connecting member may be pulled in the direction of the point of the wedge opening 861 or notch 871 to lock the connecting member in place.
  • FIG. 10Q shows a fastener 880 having a fastener member 881 having slots around its perimeter that accept connecting member 882 .
  • Member 881 may be twisted, as shown by the arrow, so that member 882 wraps around member 881 to adjust the length of member 881 between fastener members 881 , 883 .
  • member 882 can lock in a notch or like structure on member 881 .
  • FIGS. 10T and 10U show fasteners 910 and 920 respectively.
  • Fastener 910 includes two dome-shaped fastening members 911 that fully invert in the deployed position (bottom of FIG. 10T) to exert additional force against the tissue layers.
  • fastener 920 includes two dome-shaped fastening members 921 that invert in their centers when in the deployed position (bottom of FIG. 10T) to exert additional force against the tissue layers.
  • FIG. 10V shows a fastener member 930 shaped in a figure eight and having two openings.
  • a connecting member 931 may be adjusted in length between fastening members by winding member 931 around and through the openings, similar to a rappel loop.
  • a small notch in member 930 may hold member 931 once member 930 has been drawn to the desired tension.
  • FIG. 10W shows a fastener 940 that includes a loop 941 and a connection member 942 .
  • Loop 941 may comprise a cable, wire, or other suitable biocompatible material. Loop 941 extends through the tissue layers twice and joins at its ends at connection member 942 , which may be located on either side of the tissue layers, through any suitable means. Loop 941 may be tightened and excess loop portions may be excised by cutting or any other suitable method. This embodiment results in a relatively small footprint at the tissue layers.
  • FIG. 10X shows a fastener member 951 that is a spring clip.
  • spring clip 951 may be inserted over a needle 953 through which connecting member 952 extends (see top portion of FIG. 10X).
  • Spring clip 951 is extended past the distal end of needle 953 to grasp connecting member 952 adjacent tissue layers 954 (see bottom portion of FIG. 10X).
  • FIG. 10Y shows a deployed fastener 960 that includes a collet 961 and a C-spring 962 .
  • the left-hand side of FIG. 10Y shows collett 961 and C-spring 962 in undeployed positions, i.e. in an open mode.
  • collett 961 can fit over any size connecting member 963 .
  • collet 961 Once collet 961 is in position over connecting member 963 and C-spring 962 , or an O-ring or other like structure, is slipped over collet 961 , collet 961 closes on member 963 .
  • This embodiment permits fastener adjustments.
  • FIG. 10Z shows a fastener member 971 in both an open position (left-hand side) and a closed position (right-hand side).
  • Member 971 includes a cap 973 with teeth to grip a connector member 972 .
  • Cap 973 is held to the remainder of member 971 by a hinge, such as a living hinge.
  • Pulling member 972 opens cap 973 enough to let the connector member 972 adjust.
  • Cap 973 snaps back down to secure member 972 .
  • the exit of connecting member 972 from cap 973 could be at a slot or notch at an edge of cap 973 .
  • FIGS. 10 DD and 10 EE show end views of alternative fasteners 971 with caps 973 ′ and 973 ′′ respectively
  • the exit of connecting member 972 from cap 973 ′, 973 ′′ could be at a through hole 974 off-center from the fastener hole 975 (FIG. 10DD) or a slot 976 in cap 973 offset from fastener hole 975 (FIG. 10EE).
  • pulling member 972 to adjust its length will open the cap 973 ′, 973 ′′ slightly.
  • FIG. 10AA shows a fastener 980 in the undeployed (left-hand side) and deployed (right-hand side) states.
  • Fastener 980 includes fastener members 981 connected by a connecting member 982 .
  • Members 981 have an inward wedge shape that will displace some force to friction along an axis of the connecting member 982 .
  • the wedge increases surface area contact of the fastener member 981 with the tissue layers and therefore friction between the layers and the member 981 .
  • the wedge portion may include a fabric surface to increase friction.
  • the area of the fabric may be made larger than the surface area of the wedge so that the fabric may bunch up to further increase surface area and friction.
  • a fabric surface or covering may be placed over any suitable fastener member described herein.
  • FIG. 10BB shows a fastener 990 having a fastener member 991 and a connecting member 992 attached at its ends to fastening members 993 .
  • Member 991 may be a pledget or any other suitable member described herein or known in the art.
  • Members 993 may be similar to member 921 described above in connection with FIG. 10A.
  • member 992 extends through the a tissue layers and member 991 in two places. After deployment of fastener 990 , the portion of member 992 extending through member 991 may be twisted (as shown by the arrow) to place desired tension against the tissue layers.
  • Connecting member 992 may be similar to member 722 of FIG. 10A and may be a polymer suture so that ultrasonic or other energy may be used to fuse the twisted portion together by melting.
  • FIG. 10CC shows a fastener 990 ′ having a suture-like member 992 that extends through member 991 and is formed into a z-like pattern 994 on a surface of member 991 away from the tissue. Member 992 tightens between members 991 and 993 as member 992 is pulled in the direction of the arrows.
  • FIG. 10S shows a fastener 900 similar to fastener 990 except that fastener 900 has a one-piece second fastener member 902 .
  • FIGS. 10 FF, 10 GG, and 10 HH show variations of “T”-shaped fastener embodiments.
  • Fastener 1000 includes fastener members 1002 each in the shape of an “H” connected by connecting member 1001 .
  • Fastener 1010 includes “T” shaped fastener members 1011 connected by a connecting member that splits into three portions 1012 a , 1012 b , and 1012 c .
  • Fastener 1020 is much like fastener 1010 and includes “T” shaped fastener members 1021 connected by a connecting member that splits into four portions 1022 a , 1022 b , 1022 c , and 1022 d .
  • any combination of fasteners and connecting members from FIGS. 10 FF- 10 HH may be used to form a suitable fastener.
  • FIG. 10II shows various embodiments of fasteners 1030 , 1040 , 1050 that include wire frames as fastener members.
  • the wire frames may be configured in any suitable shape, including triangular, round, and irregular, as shown. It is preferable that the wire frame be collapsible into a flattened shape for ease of delivery and then expand upon deployment.
  • FIG. 10JJ shows embodiments of fasteners 1055 , 1056 having fastener members 1057 , 1058 in kite-like configurations.
  • the fastener members 1057 , 1058 may include a combination of wire material on the external perimeter portions and suture material as the spokes 1059 extending form the connecting members to the wire perimeter.
  • the fastener members may be configured in any suitable shape, including square, diamond, etc., and, as in the FIG. 10II embodiments, collapse into a flattened shape for delivery and expand upon deployment.
  • FIG. 10KK shows a fastener 1060 made of a combination of suture material 1061 connecting a pair of hypotubes 1062 .
  • the suture material connects to a connecting member 1063 at an approximate midpoint of the fastener 1060 .
  • the suture material in the embodiments of FIGS. 10 JJ and 10 KK, and any other embodiments disclosed herein, may be elastic, fuzzy (like dental floss), and/or swell upon deployment.
  • FIGS. 10 LL- 10 OO show various embodiments of fasteners designed to have an increased footprint on the tissue layers.
  • a button is placed on the esophageal side of the tissue layers and a mating cup is placed on the stomach side.
  • FIG. LL shows a button shaped fastener member 1072 adjacent esophageal tissue 1074 and a mating cup fastener member 1071 adjacent stomach tissue 1075 .
  • a connecting member 1073 extends between button 1072 and cup 1071 .
  • FIGS. 10 MM- 10 OO show other shaped buttons and mating cups.
  • FIG. 10MM shows fastener 1080 with a convex cup 1082 connected by a connecting member 1083 to a concave mating cup 1081 .
  • FIG. 10NN shows fastener 1090 with a wedge-shaped cup 1092 connected by a connecting member 1093 to a corresponding mating cup 1081 .
  • FIG. 10OO shows fastener 1100 with a convex cup 1102 connected by a connecting member 1103 to a concave mating cup 1101 surrounded by a flattened area 1104 that further increases the footprint on the tissue layers.
  • Convex, wedge, and other like-shaped buttons increase tissue contact area relative to a flat button arrangement. Other shaped buttons and mating cups may be used.
  • FIG. 10PP shows a fastener 1110 in a delivered state (top) and a deployed state (bottom).
  • Fastener 1100 is a tube or rod that includes a plurality of slits at ends 1111 . Upon deployment at the desired site, the slits at the ends permit the ends to attain a fastener member arrangement having a plurality of arms 1112 . Such deployment may be attained through a shape memory material, a deployment mechanism that separates the slits to form arms 1112 , or any other suitable method.
  • FIG. 10QQ shows a variation of the fastener embodiment shown in FIG. 10PP.
  • Fastener 1120 includes a pointed, slotted end 1121 that, when deployed, shapes into arms 1122 . The pointed end may permit puncturing through the tissue layers. The pointed tip may remain, may be removed through any mechanical, thermal or other suitable method, or may be made of a absorbable material.
  • FIG. 10RR shows a fastener 1130 that includes a connecting member 1132 with expandable fastener members 1131 at each end.
  • the top portion of FIG. 10RR shows the delivered state in which members 1131 remain in a collapsed configuration, and the bottom view shows members 1131 in a deployed configuration.
  • Members 1131 may be balloons and may be expanded by fluid actuation or any other suitable method.
  • fastener 1130 may be modified to include a pointed tip.
  • FIG. 10SS shows fasteners 1140 and 1150 having fastener members 1141 , 1151 respectively that include non-straight connector pathways. Such pathways create an interference between the connecting member 1142 , 1152 and the member 1141 , 1151 to aid in securing them together.
  • member 1141 includes a wavy, or serpentine, pathway for member 1142
  • member 1151 includes a pathway with a bend. Other non-straight pathways may be used.
  • FIG. 10R shows a fastener 890 having a plurality of connecting members 891 across the tissue layers to spread the force applied to the tissue surfaces.
  • the connecting members 891 may be unconnected at their ends, or may be connected at their ends to be a single member wrapped around the fastener members 892 , 893 .
  • friction between the connector member and the fastener members may be increased by a rough surface on the connector member (by for example braiding, knots, fibers), an elastic connecting member, a coated connecting member, or a fabric covered connecting member.
  • the through hole of the fastener member(s) may include gripping teeth arranged at an angle to prevent reverse movement of the connecting member.
  • Embodiments as appropriate throughout this specification also may include a quick-setting, water tolerant adhesive or glue, such as cyanoacrylate, may be used to pack the passage or hole within a fastening member.
  • FIGS. 9A through 9J show various other exemplary connecting members according to other embodiments of the present invention.
  • a connecting member can be formed of a telescopic bar 701 , a collapsible bellows 702 , a cylindrical bar with a ball-socket arrangement 703 , a stent-like braided configuration 704 , a spiral-shaped spring 705 , a webbed spiral spring 706 , a crimped structure 707 , ratchet 708 , elastic member 710 , or webbed member 712 .
  • the connecting member 705 is formed of a spiral-shaped spring.
  • the spiral-shaped spring may be covered with a conforming material 706 a , such as, for example, polyurethane, silicone, polytetrafluoroethylene, webbed material or other suitable material.
  • the connecting member 707 is configured to be coupled to a fastening member 618 .
  • a pledget 717 or a ring is utilized to couple between the connecting member 707 and the fastening member 618 to allow moveability of the fastening member 618 along the connecting member 707 .
  • the connecting member 708 includes at least one skirt-like or frustoconical-shaped ratchet 708 a which permits movement only in one direction.
  • FIG. 9I illustrates a post embodiment wherein the post comprises an elastic material.
  • the embodiment of FIG. 9J illustrates a post 712 comprising a webbed material, for example, a knit or woven material. Any other suitable designs providing the similar function may be utilized.
  • a connecting member 701 - 712 is preferably strong enough to maintain its integrity and utility even under stressful events, such as running, swimming, sneezing, coughing, vomiting, or the like. These connecting members 701 - 712 can provide compressive forces to enhance the fastening of the tissues. In addition, these connecting members 701 - 712 provide enhanced flexibility for traversing through a tortuous path within a body.
  • tissue fasteners especially those that expand from a contracted, delivered state to an expanded, deployed state, may be made of a shape memory material, such as, for example, nickel titanium alloy (e.g., Nitinol) or a polymer.
  • a shape memory material such as, for example, nickel titanium alloy (e.g., Nitinol) or a polymer.
  • the fastening member is able to transform from its delivered state to its deployed, functional state automatically upon deployment.
  • the reconfiguration can be obtained by utilizing a material that is reactive to a predetermined condition, e.g., temperature, pH, electrical current, and/or a number of other internal and external stimuli or by its material properties such as elasticity.
  • the expandability of the distal and proximal fastening members can also be obtained by utilizing any suitable mechanical means, such as, for example, a manually actuated expander.
  • the disclosed tissue fasteners are preferably composed of a biocompatible and biocompliant material, i.e. similar to the compliance of the tissue being connected.
  • the fasteners also may be coated with thrombogenic agents and therapeutics to prevent tissue inflammation.
  • materials for a tissue fastener including its coating or covering, include silicone-based polymers, nylon-based polymers, hydrid Teflon-textile based polymers, polypropylene, polyethlylene, or growth factors.
  • Polymer coating materials further include polycarboxylic acids, cellulosic polymers (e.g., cellulose acetate and cellulose nitrate), gelatin, polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone, polyanhydrides (e.g., maleic anhydride polymers), polyamides, polyvinyl alcohols, copolymers of vinyl monomers (e.g., EVA), polyvinyl ethers, polyvinyl aromatics, polyethylene oxides, glycosaminoglycans, polysaccharides, polyesters (polyethylene terephthalate), polyacrylamides, polyethers, polyether sulfone, polycarbonate, polyalkylenes, halogenated polyalkylenes (e.g., polytetrafluoroethylene), polyurethanes, polyorthoesters, proteins, glycoproteins, recombinant proteins, polypeptides, silicones, siloxane polymers, polylactic acid
  • the fastener comprises a bioabsorbable material.
  • a preferred coating would be one which would minimize tissue inflammation around the fastener.
  • the disclosed tissue fastener can be made of biodegradable, bioresorbable, and/or bioabsorbable material.
  • the clamping force created by the fastener will induce adhesion formation between the tissue layers. This can occur in a controlled fashion by carefully selecting a material with a predetermined degradation rate.
  • the bioabsorbable material may be formed of cross-linked polymer networks that can be manufactured to be responsive to body temperature, light, pH, and/or a number of other external/internal stimuli.
  • FIGS. 11 A-C Deployment of a tissue fastener is discussed below with reference to an exemplary endoluminal deployment system, shown in FIGS. 11 A-C.
  • the tissue fastener 1 shown in FIG. 2 is used to illustrate various deployment stages of a tissue fastener, according to an embodiment of the present invention.
  • the deployment system may be used with various other embodiments of tissue fasteners described above.
  • the deployment system 50 includes a flexible overtube 52 configured to accommodate a tissue fastener 1 in a delivered state, and a coupling mechanism 53 for grasping and moving the tissue fastener 1 along the lumen of the overtube 52 .
  • the deployment system 50 may also be configured to accommodate multiple tissue fasteners that are stacked axially.
  • the coupling mechanism may be a mechanical grasper 53 that is remotely operable by suitable actuation means at the proximal end (not shown) of the overtube 52 .
  • the system 50 also includes a pusher 54 for guiding the tissue fastener along the overtube 52 .
  • the pusher 54 may include a hollow lumen through which a cable for operating the grasper 53 passes.
  • the overtube 52 includes a lumen 56 preferably having a diameter capable of accommodating the tissue fastener 1 .
  • the overtube 52 may be incorporated into a conventionally known endoluminal fundoplication device, described in U.S. Pat. No. 6,086,600, the disclosure of which is hereby incorporated by reference.
  • a device as taught in that patent may be used to fold the esophageal and fundus walls together, with overtube 52 then used to apply one or more fasteners.
  • the overtube 52 is preferably made of polymer, polymer reinforced with metal, or metal hypotube.
  • the overtube is preferably low in profile and flexible enough to traverse the cricopharyngeal area transorally.
  • FIGS. 18A and 18B show an exemplary embodiment of deployment system 50 , wherein a grasper 53 is fixedly connected to a distal end of a pusher 54 .
  • Grasper 53 includes a pair of arms 53 ′ each terminating in bent hooks 53 ′′. Arms 53 ′ are elastic and biased in the open position shown in FIG. 18B.
  • arms 53 ′ are contracted within overtube 52 , ands hooks 53 ′′ mate with a head 11 ′ of fastener member 11 to hold the fastener to be deployed.
  • the fastener may be attached to an external mechanism, such as a wire, that runs outside the body.
  • the external wire then may carry the electrical current to electrically detach the fastener when installation of the tissue fastener is complete.
  • Technology known as a Gugliemi Detachable Coil (GDC) or GDC coil detachment, such as that described in U.S. Pat. No. 5,423,829, incorporated by reference herein, may be used in connection with this embodiment.
  • the tissue fastener 1 is contained within the flexible overtube 52 and endoluminally delivered to a desired site in a body to protect the body lumen from possible damage caused by the sharp edge 15 of the tissue fastener 1 .
  • the tissue fastener 1 is advanced toward the tissue surface, such that the sharp edge 15 of the tissue fastener 1 makes contact with the tissues to be perforated.
  • the tissue fastener may be configured to perforate through the tissue layers, or may be configured to pass through an opening already made by other perforating instruments or the overtube 52 .
  • the overtube may include a sheath covering it to puncture through tissue.
  • the distal fastener member 13 is further advanced out of the overtube 52 , and the anchor legs 23 are expanded outwardly to form an umbrella-shaped fastening member 13 , as shown in FIG. 11C, to hold the tissue layers together.
  • FIGS. 12A through 16 show implantation of a tissue fastener 1 in a fundoplication procedure, using the endoluminal deployment system shown in FIGS. 11 A- 11 C.
  • the deployment includes performing the delivery and placement of the tissue fastener 1 in essentially one step.
  • the deployment system 50 containing the tissue fastener 1 is transorally inserted into the lower esophagus 3 and positioned adjacent to a desired location near the distal end of the esophagus 3 for the fundoplication procedure.
  • the fundus wall 6 is lifted and folded toward the esophageal wall 4 as shown in FIG. 12A.
  • Any suitable mechanism for lifting the fundus wall 6 toward the esophageal wall 4 may be used for this purpose.
  • An example of such a suitable device is shown and described in U.S. Pat. No. 6,086,600, the entire disclosure of which is incorporated by reference herein. It should also be understood that the lifting device may be formed in combination with the endoluminal deployment system 50 .
  • tissue fastener 1 After the distal end opening 55 of the overtube 52 positioned proximate a desired perforation site of the esophageal wall 4 , the tissue fastener 1 is advanced toward the esophageal wall surface, such that the sharp edge 15 of the tissue fastener makes contact with the surface, as illustrated in FIG. 12B Tissue fastener 1 preferably extends out of the overtube 52 only enough so that the edge 15 extends from the opening 55 , yet a portion of legs 23 remain in the overtube 52 so that the distal fastening member 13 remains in a contracted state.
  • the tissue fastener 1 may be configured to cut through the esophageal wall 4 and the fundus wall 6 , or may be configured to penetrate through an opening already made by other instrument or the overtube 52 . As shown in FIG. 13, the overtube 52 with the sharp edge 15 of the tissue fastener 1 protruded out of the overtube 52 is advanced through the esophageal wall 4 and the fundus wall 6 .
  • the distal fastening member 13 of the tissue fastener 1 is further advanced out of the overtube 52 causing the anchor legs 23 of the distal fastening member 13 to expand outwardly to form an umbrella-shaped fastening member 13 , as shown in FIG. 14.
  • the overtube 52 is withdrawn and releases the tissue fastener 1 to completely expose the proximal fastening member 11 of the tissue fastener 1 .
  • the anchor legs 21 of the proximal fastening member 11 expand outwardly to form the fastening member 11 .
  • the proximal fastening member 11 of the tissue fastener 1 is a perspective view of the proximal fastening member 11 of the tissue fastener 1 , viewing from inside the esophagus, after the deployment is complete.
  • the distal fastening member 13 i.e., the gastric side
  • the proximal fastening member 11 i.e., esophageal side
  • FIG. 16 is a cross-section view of the esophageal wall 4 and the fundus wall 6 , with a tissue fastener in place, after the fundoplication procedure is complete.
  • the expanded distal and proximal fastener members 13 , 11 of the tissue fastener 1 hold and maintain the esophageal and fundus walls 4 , 6 together in place to create the fundoplication.
  • the tissue fastener 1 should be strong enough to hold the esophagus and fundus together with a force of approximately 6 lbs without damage to the esophageal wall 4 or fundus wall 6 .
  • tissue fastener 1 should be sufficiently strong enough to maintain its integrity and utility even under stressful events, such as running, swimming, sneezing, coughing, vomiting, or the like.
  • more than one tissue fastener may be installed. In that instance, a deployment system capable of loading multiple tissue fasteners can be used.
  • tissue fastener 1 The invention is not limited to the exemplary embodiment used to illustrate the deployment of the tissue fastener 1 .
  • Other various tissue fasteners encompassed in this disclosure can be used with the deployment systems and methods described above.
  • the disclosed tissue fasteners of the present invention can be used with any other deployment mechanisms conventionally known in the art.
  • an opening through the esophageal wall 4 and the fundus wall 6 can be made by other piercing instruments, or the endoluminal deployment system 70 having a cutting edge 40 on its distal tip, as shown in FIGS. 17A and 17B.
  • FIGS. 17A and 17B illustrate endoluminal deployment systems 70 used for the disclosed tissue fasteners, according to still other embodiments of the present invention. Similar to the deployment system 50 shown in FIGS. 10 A-C, the deployment system 70 shown in FIGS. 17A and 17B includes a flexible overtube 71 having either a straight or curved distal portion and configured to accommodate a tissue fastener 70 in a contracted state. Fastener 70 is represented with fastening head 74 and connector 72 , but this illustration is not intended to limit the possible embodiments. In this embodiment, overtube 71 is represented as a needle.
  • Overtube 71 may be of any size necessary to deploy fastener 71 while working within the confines of anatomical space and instrument space needed to fold and retain the fundus against the esophageal wall.
  • the overtube 71 includes an opening 45 at its distal tip, through which a tissue fastener passes.
  • the opening 45 is defined by a slanted edge to form a sharp cutting edge 40 .
  • the sharp cutting edge 40 forms an opening through the tissue layers prior to the deployment of a tissue fastener.
  • the fastener 70 is deployed by releasing a fastening head on one side of the tissue layers undergoing attachment and withdrawing overtube 71 from the tissues to release a second fastening head on the opposite tissue layer side.
  • tissue fastener and related deployment methods and systems of the present invention can be used to treat any of a number of different disease conditions, and can be used for fastening any desired body tissues.

Abstract

Surgical tissue fasteners and related deployment systems and methods are disclosed. A tissue fastener used to join multiple tissue layers includes a first member, a second member, and a connecting member connecting the first and second members. In some embodiments, the first and second members are configured to expand from a delivered state to a deployed state in which the fastener secures the tissue layers together. Other tissue fastener embodiments include means for applying a substantially constant force on the tissue layers and/or means for adjusting a length of the connecting member between the first and second members.

Description

    CROSS-REFERENCE TO RELATED APPLICATION
  • This application relates to commonly assigned U.S. Application Serial No. ______ of Robert Devries et al., filed on the same date as this application, and entitled “Devices and Methods for Fastening Tissue Layers.” The complete disclosure of that application is incorporated by reference herein.[0001]
  • DESCRIPTION OF THE INVENTION
  • 2. 1Field of the Invention [0002]
  • The present invention relates to surgical tissue fasteners and related deployment systems and methods for delivering the tissue fasteners. In particular, the present invention relates to tissue fasteners used in, for example, a fundoplication procedure for treatment of Gastroesophageal Reflux Disease (GERD). [0003]
  • 2. Background of the Invention [0004]
  • Gastroesophageal reflux occurs when stomach acid enters the esophagus. This reflux of acid into the esophagus occurs naturally in healthy individuals, but also may become a pathological condition in others. Effects from gastroesophageal reflux range from mild to severe. Mild effects include heartburn, a burning sensation experienced behind the breastbone. More severe effects include a variety of complications, such as esophageal erosion, esophageal ulcers, esophageal stricture, abnormal epithelium (e.g., Barrett's esophagus), and/or pulmonary aspiration. These various clinical conditions and changes in tissue structure that result from reflux of stomach acid into the esophagus are referred to generally as Gastroesophageal Reflux Disease (GERD). [0005]
  • Many mechanisms contribute to prevent gastroesophageal reflux in healthy individuals. One such mechanism is the functioning of the lower esophageal sphincter (LES). With reference to FIG. 1, the [0006] LES 2 is a ring of smooth muscle and increased annular thickness existing in approximately the last four centimeters of the esophagus. In its resting state, the LES creates a region of high pressure (approximately 15-30 mm Hg above intragastric pressure) at the opening of the esophagus 3 into the stomach 7. This pressure essentially closes the esophagus 3 so that contents of the stomach cannot pass back into the esophagus 3. The LES 2 opens in response to swallowing and peristaltic motion in the esophagus 3, allowing food to pass into the stomach. After opening, however, a properly functioning LES 2 should return to the resting, or closed state. Transient relaxations of the LES 2 do occur in healthy individuals, typically resulting in occasional bouts of heartburn.
  • The physical interaction occurring between the [0007] gastric fundus 5 and the esophagus 3 also prevents gastroesophageal reflux. The gastric fundus 5 is a lobe of the stomach situated at the top of the stomach 7 distal to the esophagus 3. In asymptomatic individuals, the fundus 5 presses against the opening of the esophagus 3 when the stomach 7 is full of food and/or gas. This effectively closes off the esophageal opening to the stomach 7 and helps to prevent acid reflux back into the esophagus 3. More specifically, as the food bolus is immersed in gastric acid, it releases gas which causes the fundus 5 of the stomach 7 to expand and thereby exert pressure on the distal esophagus 3 causing it to collapse. The collapse of the esophagus lumen reduces the space for the stomach acid to splash past the closed esophagus lumen and thereby protect the proximal esophagus from its destructive contact.
  • In individuals with GERD, the [0008] LES 2 functions abnormally, either due to an increase in transient LES relaxations, decreased muscle tone of the LES 2 during resting, or an inability of the esophageal tissue to resist injury or repair itself after injury. These conditions often are exacerbated by overeating, intake of caffeine, chocolate or fatty foods, smoking, and/or hiatal hernia. Avoiding these exacerbating mechanisms helps curb the negative side effects associated with GERD, but does not change the underlying disease mechanism.
  • A surgical procedure, known generally as fundoplication, has been developed to prevent acid reflux in patients whose normal LES functioning has been impaired, either as a result of GERD or other adverse effects. This procedure involves bringing the [0009] fundus wall 6 into closer proximity of the esophageal wall 4 to help close off the esophageal opening into the stomach 7. Traditionally, this procedure has been performed as an open surgery, but also has been performed laparoscopically.
  • As with any surgery, the attendant risks are great. Due to relatively large incisions necessary in the performance of open surgery, relatively large amount of blood is lost, the risk of infection increases, and the potential for post-operative hernias is high. Further, the relatively large incisions necessary in the performance of open surgery require extended recovery times for the incision to heal. [0010]
  • A laparoscopic procedure may involve performing laparotomies for trocar ports (penetrations of the abdominal wall), percutaneous endoscopic gastronomies (incisions through the skin into the stomach), and the installation of ports through which, for example, a stapler, an endoscope, and an esophageal manipulator (invagination device) are inserted. Under view of the endoscope, the esophageal manipulator is used to pull the interior of the [0011] esophagus 3 into the stomach 7. When the esophagus is in position, with the fundus 5 of the stomach plicated, the stapler is moved into position around the lower end of the esophagus and the plicated fundus is stapled to the esophagus 3. The process may be repeated at different axial and rotary positions until the desired fundoplication is achieved. This procedure is still relatively invasive requiring incisions through the stomach, which has a risk of infection. The location of the incision in the abdominal wall presents a risk of other negative effects, such as sepsis, which can be caused by leakage of septic fluid contained in the stomach.
  • SUMMARY OF THE INVENTION
  • Therefore, one embodiment of the present invention provides less invasive devices and methods for performing the fundoplication procedure. This is achieved by utilizing tissue fasteners and related deployment systems which can be endoluminally delivered through the [0012] esophagus 3, thereby eliminating the need for highly invasive, physiologically insulting surgical procedures.
  • To attain the advantages and in accordance with the purpose of the invention, as embedded and broadly described herein, one aspect of the invention provides a tissue fastener used to join multiple tissue layers. The tissue fastener includes a proximal member configured to expand from a delivered state to a deployed state, a distal member configured to expand from a delivered state to a deployed state, and a connecting member connecting the proximal member to the distal member. In the deployed state, the proximal member and the distal member secure the multiple tissue layers together. [0013]
  • Another aspect of the invention provides a tissue fastener used to join multiple tissue layers that includes a first member, a second member, a connecting member connecting the first member to the second member, and means for applying a substantially constant force on the tissue layers. In some embodiments, the applying means may be compressible. [0014]
  • Another aspect of the invention provides a tissue fastener used to join multiple tissue layers that includes a first member, a second member, a connecting member connecting the first member to the second member, and means for adjusting a length of the connecting member between the first and second members. In some embodiments, the adjusting means may include structure associated with the first member for releasably securing the connecting member to the first member. That structure may be configured to restrict passage of the connecting member in a direction through the first member. [0015]
  • Another aspect of the present invention is to provide a delivery system configured for deployment of an expandable tissue fastener. The system includes a flexible tube configured to accommodate a tissue fastener in a contracted state, a pusher for guiding the tissue fastener along a lumen of the tube, and a grasper coupled to a distal end of the pusher and having means to grasp the tissue fastener. [0016]
  • In yet another aspect of the present invention, a method of attaching a first layer of tissue to a second layer of tissue includes providing an expandable tissue fastener in a contracted state in a device, the tissue fastener having a proximal member and a distal member, inserting the device into a body passage leading to the first tissue wall, placing the device proximate a location on the first tissue layer, passing the device through the first and second tissue layers, advancing the tissue fastener toward an opening of the device, such that the distal member is completely protruded out of the device and expanded against the second tissue layer, and withdrawing the device and releasing the tissue fastener, such that the proximal member is expanded against the first tissue layer. [0017]
  • The present invention is depicted in this disclosure and is particularly suitable in the treatment of GERD, e.g., a fundoplication procedure. However, the tissue fasteners and related deployment methods and systems of the present invention can be used to treat any of a number of different disease conditions, and can be used for fastening any desired body tissues. [0018]
  • Additional objects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objects and advantages of the invention will be realized and attained by means of the elements and combinations particularly pointed out in the appended claims. [0019]
  • It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed.[0020]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate several embodiments of the invention and together with the description, serve to explain the principles of the invention. [0021]
  • In the drawings: [0022]
  • FIG. 1 is a cross-sectional view of the gastrointestinal tract in the region of the lower esophageal sphincter (LES) and the fundus of the stomach; [0023]
  • FIG. 2 is a perspective view of a tissue fastener, prior to deployment into a body, according to an embodiment of the present invention; [0024]
  • FIG. 2A is a perspective view of a proximal fastening member of the tissue fastener of FIG. 2, showing the proximal fastening member in a deployed state according to an embodiment of the present invention; [0025]
  • FIG. 2B is a perspective view of a distal fastening member of the tissue fastener of FIG. 2 in a deployed state, according to an embodiment of the present invention; [0026]
  • FIGS. [0027] 3-7C are perspective views of various tissue fasteners according to various embodiments of the present invention;
  • FIGS. [0028] 7D-7F are cross-sectional views of tissue fastener members according to various embodiments of the present invention;
  • FIGS. [0029] 8A-8R are perspective views of various designs of tissue fastening members according to additional embodiments of the present invention;
  • FIGS. [0030] 9A-9J are perspective views of various connector post designs according to still other embodiments of the present invention;
  • FIGS. [0031] 10A-10SS are perspective views of fasteners according to various embodiments of the present invention;
  • FIGS. [0032] 11A-C are perspective views of an endoluminal deployment system, illustrating various operational stages of the system for deployment of a tissue fastener, according to an embodiment of the present invention;
  • FIG. 12A is a schematic illustration of the tissue fastener deployment for a tissue connection procedure, showing the deployment system of FIGS. [0033] 11A-C containing the tissue fastener of FIG. 2 and being inserted into the lower esophagus, according to an embodiment of the present invention;
  • FIG. 12B is a schematic illustration of the tissue fastener deployment, showing the deployment system penetrating the esophageal wall, according to an embodiment of the present invention; [0034]
  • FIG. 13 is a schematic illustration of the tissue fastener deployment, showing the deployment system penetrating the esophageal wall and the fundus wall, according to an embodiment of the present invention; [0035]
  • FIG. 14 is a schematic illustration of the tissue fastener deployment, showing the expanded distal fastener member of the tissue fastener holding the fundus wall, according to an embodiment of the present invention; [0036]
  • FIG. 15 is a perspective view of a proximal fastening member of the tissue fastener of FIG. 2, viewing from inside the esophagus, after the deployment is complete, according to an embodiment of the present invention; [0037]
  • FIG. 16 is a cross-sectional view of the esophageal wall and the fundus wall, with a tissue fastener in place, after the tissue connection procedure; [0038]
  • FIG. 17A is a perspective view of a deployment system, with a straight distal tip, according to another embodiment of the present invention; [0039]
  • FIG. 17B is a perspective view of a deployment system, with a curved distal tip, according to still another embodiment of the present invention; and [0040]
  • FIGS. 18A and 18B are views of a deployment system respectively holding and releasing a tissue fastener member.[0041]
  • DESCRIPTION OF THE EMBODIMENTS
  • Reference will now be made in detail to the exemplary embodiments of the invention, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts. [0042]
  • A newly developed form of fundoplication, referred to as endoscopic fundoplication, is an endoluminal procedure in which the [0043] fundus wall 6 is folded back onto the esophagus wall 4. The tissue fold formed between the esophagus 3 and the fundus 5 then is secured. Endoscopic fundoplication is intended to be performed as an endoluminal procedure in which insertion of required medical instruments occurs through the esophagus 3. Such a procedure has the benefits of being less invasive, quicker, and less expensive as compared to previous techniques.
  • FIG. 2 shows an exemplary embodiment of a [0044] tissue fastener 1 for use in a fundoplication procedure. The tissue fastener 1 has a distal fastening member 13, a proximal fastening member 11, and a connecting member 12 connecting the distal fastening member 13 and the proximal fastening member 11 to each other. The distal fastening member 13, the proximal fastening member 11, and the connecting member 12 are formed as an integrated unit or two or more components pieced together. The distal fastening member 13 includes a plurality of anchor hooks or legs 23, and the proximal fastening member 11 includes a plurality of anchor hooks or legs 21. The plurality of anchor legs 21, 23 are constructed to expand from a contracted state to an expanded state. When the legs are in the contracted state, as shown in FIG. 2, the tissue fastener 1 is low in profile and can be loaded into a narrow lumen of an endoluminal deployment system for deployment. Once the deployment system is positioned into a desired location within a body, the plurality of anchor legs 21, 23 are expanded outwardly to fasten multiple tissue layers together between the distal and proximal fastening members 13, 11, thereby enhancing the tissue connection.
  • In this particular embodiment shown in FIG. 2, each of the distal and [0045] proximal fastening members 11, 13 is provided with a total of six anchor legs 21, 23, that are equally spaced apart. However, it should be recognized that the fastening members 11, 13 can be provided with more or less number of legs 21, 23 with different desired spacing therebetween.
  • Preferably, the leading edge of the [0046] distal fastening member 13 forms a sharp point or edge 15 to assist with penetrating through the tissue layers. The sharp edge 15 may be a trocar-like cutting edge to perform the perforation of the layers itself. It should also be recognized that forming such a sharp cutting edge 15 may not be necessary if an endoluminal deployment system includes a cutting edge 40 on its distal tip, as shown in FIGS. 17A-B to be described herein.
  • FIGS. 2A and 2B show the expanded state of the proximal and [0047] distal fastening members 11, 13, respectively in an installed state. When the distal fastening member 13 is freed from a restraining means of an endoluminal deployment system, the anchor legs 23 of the distal fastening member 13 expand outwardly to form an umbrella-shaped fastening member. Sharp edge or tip 15 may be removed or made of a dissolvable, biodegradable material. Similarly, when the proximal fastening member 11 is freed from a restraining means of an endoluminal deployment system, the anchor legs 21 of the proximal fastening member 11 expand outwardly to form a fastening member. Each of the anchor legs 21 of the proximal fastening member 11 may include one or more bending portions 22 at a location along the length of the leg 21, such that the distal portion 24 of the leg 21 extends outwardly with respect to the bending portion 22. The bending portion 22 is a relatively flexible portion of an otherwise substantially rigid leg 21. The bending portion 22 may be facilitated by removal of material or change in geometry along the leg 21. The leg 21 may further comprise a variable stiffness along the leg 21. For example, the bending portion 22 may consist of a lower stiffness material to facilitate the bending.
  • FIGS. 3 through 7 are perspective views of various tissue fasteners in expanded states according to other embodiments of the invention. In an embodiment shown in FIG. 3, the [0048] tissue fastener 101 is formed of at least two elongate members 150, such as wires or rods, interconnected in the mid-portion by a connecting member 112. The interconnection may be made through any suitable method, such as welding, brazing, molding, a locking mechanism, etc., or members may be manufactured as an integral piece. In a contracted state, each member 150 is preferably substantially straight to promote easier insertion through the esophagus and deployment. In an expanded state, shown in the figure, each member 150 bends outwardly, substantially perpendicular to the connecting member 112, to form the distal and proximal fastening members 113, 111. The ends of the proximal fastening member 111 could be rounded or otherwise protected to reduce trauma when in contact with tissue. Similar to the embodiment shown in FIG. 2, the leading edge of each member 150 may form a sharp cutting edge 115 to assist with perforating layers of tissues.
  • FIG. 3A illustrates a further embodiment of the fastener of FIG. 3 wherein the distal and proximal ends of the [0049] fastener 101 turn inwards upon deployment through tissue layers. These inward turns, or hooks 114, would contact tissue and prevent migration of fastener 101.
  • According to another embodiment shown in FIG. 4A, the [0050] tissue fastener 201 is comprised of a single wire 250 or rod. Similar to the tissue fastener 101 of FIG. 3, the wire 250 preferably forms a substantially straight wire in a contracted state. In an expanded state, shown in the figure, the wire 250 forms spiral-shaped distal and proximal fastening members 213, 211 at both ends of the that are substantially perpendicular to the connecting member 212. The wire 250 a may also form a spring-shaped fastening member 211 a, 213 a at both ends of the wire 250 a, as shown in FIG. 4B. In that case, the spring-shaped fastening members 211 a, 213 a may be substantially parallel to the connecting member 212 a. The leading edge of the wire 250 may form a sharp cutting edge 215 to assist with perforating layers of tissues. As a modification and alternative to fastener 201, a wire fastener may be delivered in a straight configuration and forms into a coil that may be screwed into the tissue layers. As described below, a suitable material for such fasteners is nitinol.
  • The [0051] tissue fastener 301 shown in FIG. 5A is comprised of multiple wires integrally attached to a connecting member 312. In a contracted state, each wire 350 preferably forms a substantially straight wire and, in an expanded state, shown in the figure, the wires 350 expand outwardly to form spider-shaped distal and proximal fastening members 313, 311. While the leading edges of the wires 350 may form sharp cutting edges to assist with perforating the tissue layers, it may be most beneficial to use an endoluminal deployment system with a trocar-like cutting edge, such as the device shown in FIGS. 17A-B, or other perforating instrument to form an opening through the tissue layers prior to the deployment of the tissue fastener 301. In an alternative embodiment to FIG. 5A, and as shown in FIG. 5B, the fastening members 311,313 may include inwardly bent hooks 352 at each end portion of the wires 350 to prevent migration of the fastener once deployed onto the tissue layers.
  • As shown in FIG. 6, the [0052] tissue fastener 401 has a similar configuration as the tissue fastener 1 shown in FIG. 2, except that the distal and proximal fastening member 413, 411 have the same configuration, much like the fastening member 11 shown in FIG. 2. In particular, the distal fastening member 413 does not include a sharp pointed edge. For this tissue fastener 401, an endoluminal deployment system with a trocar-like cutting edge (e.g., a device shown in FIGS. 17A-B) can be utilized.
  • FIG. 7A shows a [0053] tissue fastener 501, also similar to the tissue fastener 1 shown in FIG. 2 in certain respects. The tissue fastener 501 has a distal fastening member 513, a proximal fastening member 511, and an adjustable connecting member 512. The distal fastening member 513 and the proximal fastening member 511 function in a similar manner as these corresponding structures of the tissue fastener 1 shown in FIG. 2. In the embodiment shown in FIG. 7A, the tissue fastener 501 includes an adjustable connecting member 512. Once fastener 501 has been placed through the tissue layers to be connected, tail 520 of fastener 501 is pulled taut as illustrated in FIG. 7B and fastening member 511 is advanced forward. This action creates a compressive force on the tissues between the fastening members 511 and 513. Alternatively, the connecting member 512 has an elastic compressive spring force which exerts pulling force between the distal and proximal fastening members 513, 511 so that the fastening of the multiple tissue layers is enhanced.
  • The elastic compressive force may be further combined with the adjustable system as described. FIGS. 7C through 7F illustrate adjustable fasteners of the present invention. FIG. 7C illustrates a [0054] fastener 520 have fastening members 513 and 511 and an adjustable connecting member 521. Member 521 further includes bumps (or notches) 514 which allow fastening member 511 to ratchet forward as either member 511 is advanced or connecting member 521 is pulled taut to connect tissue layers. FIGS. 7D through 7F illustrate cross-sectional views of two ratcheting systems as described. In FIG. 7D, the ratcheting action is created by virtue of flexible tabs 515 located inside fastening member 511. FIGS. 7E and 7F illustrate friction based or infinite ratcheting systems wherein the interference fit of a single tab 515 of FIG. 7E or of multiple tabs 515 of FIG. 7F serve to keep connecting member 521 from slipping once fastening member 511 is advanced forward onto tissue or connecting member 521 is pulled taut. If connecting member 521 is at least partially elastic, the fastener may be self adjusting once in place or the force within the fastener upon the tissues may be controlled.
  • FIGS. 8A through 8O show various other exemplary fastening members according to various embodiments of the present invention. As shown in the figures, the fastening member can be formed of a [0055] flat plate 601 of virtually any geometric shape, a semispherical domed button 602, a flexible plate 603, a malecot 604, a ratchet 606, a non-orthogonal button 607, interconnectable multiple pieces 608, a foldable T-shaped bar 609, a twisted or tied coil, string, or other flexible elongate member 610, a stent-like configuration 611 wherein the connecting member has a crimped, braided configuration, a cotterpin 612, a rivot 613, a V-shaped clip 614, 615 with or without a flattened top (FIGS. 8N and 8P), a staple-like configuration (FIG. 8O), and stent-like connectors with dogbone or flared ends (FIGS. 8Q and 8R). Each fastening member connects to or comprises a connecting member 650.
  • These various fastening member embodiments will now be described in more detail. In an embodiment shown in FIG. 8D, the [0056] malecot 604 includes a plurality of legs or rods 604 a that assume a cage-like shape when in its normal, expanded position. In another embodiment shown in FIG. 8F, the fastening member 606 includes at least one skirt-like or frustoconical-shaped ratchet 606 which permits movement only in one direction. In yet another embodiment shown in FIG. 8G, a non-orthogonal connection between the connecting member 650 and the fastening member 607, which may include any of the described fastening members, is provided. In still another embodiment shown in FIG. 8H, the fastening member 608 is formed of multiple pieces that are attached through any suitable means, such as piercing members or barbs. In still another embodiment shown in FIG. 81, the fastening member 609 is pivotally coupled to the connecting member 650 to form a T-shaped configuration. Any conventional connecting devices and methods may be used to couple the fastening member 609 and the connecting member 650. In still another embodiment shown in FIG. 8J, the fastening member 610 is formed of a twisted or tied element. Preferably, the member 610 is made of a single piece and double-looped. In still another embodiment shown in FIG. 8K, the fastening member 611 is formed of a stent-like braided configuration. The middle portion of the configuration is crimped by a plurality of rings or is wrapped with a coil and constitutes the connecting member. In an expanded state, rings are removed or a coil is partially unwrapped at the distal end portion, or the distal end is not otherwise crimped like the connecting member portion, to form a fastening member 611 shown in the figure. FIGS. 8Q and 8R illustrate stent type fasteners 660, 670 respectively having a dogbone or flare shape at each end. These fasteners are deployed in a constricted manner and expanded or allowed to expand into a fastener comprised of a singular structure. The fasteners of FIGS. 8K, 8Q, and 8R may be constructed in any manner similar to fabricating stents as is known in the art, including but not limited to knitting, weaving, twisting, laser-cut tubes, welded wires and molding.
  • In still another embodiment shown in FIG. 8L, the [0057] fastening member 612 is formed of a bar or a plate, fixedly attached the connecting member by a cotterpin 612 a or a stopper. In still another embodiment shown in FIG. 8M, the fastening member 613 is formed by attaching a rivot to the connecting member 651. In this case, the connecting member 651 includes an engagement member 653 protruding outwardly at its distal end, which engages the rivot to form the fastening member 613. In still another embodiment shown in FIG. 8N, the fastening member 614 is a clip having two or more legs 614 b. The clip is expandable in a transverse direction, as indicated by arrows in the figure, thereby enhancing the tissue connection. Preferably, one or more bands or O-rings 614 a are attached to limit the expansion to a desired extent and to abut the tissue layers. It should also be recognized that a plate or other flat surface 614 c may be attached to, or otherwise be integral with, the expanded clip at its distal end, as shown in FIG. 8P.
  • In still another embodiment shown in FIG. 8O, the [0058] fastening member 616 forms a staple-like configuration. Similar to the embodiments shown in FIGS. 3-5, the wire 616 a preferably forms a substantially straight wire in a contracted state and, in an expanded state, shown in the figure, the wire 616 a expands outwardly or inwardly to form the staple-like configuration. Alternatively, an anvil can be placed behind tissue layers to bend the wires 616 a and form the staple-like configuration. It should be recognized that more than two wires can be provided. Any other suitable designs providing the similar function may be utilized. In addition, the fastener may include any combination of fastening members and connecting posts.
  • In an embodiment, as shown in FIG. 8E, a [0059] tissue fastener 605 also may include a hollow bore 630 passing through the tissue fastener to inject a therapeutic chemical agent or an adhesion promoting substance. The tissue fastener is provided with an injection port 670 to permit introduction of the therapeutic substances or the adhesion promoting substance. The hollow bore 630 may be provided with a one-way valve (e.g., check valve) 672 to prevent a backflow. Fastener 605 may also comprise a weep hole 660 or other means along post 662 to allow delivery of the chemical agent or adhesion promoting means between the tissue layers.
  • FIGS. [0060] 10A through 10OO show various other exemplary fastening members according to various embodiments of the present invention. These various embodiments, in addition to certain others described throughout this specification, adjust to varying tissue thickness so that sufficient tension, and in many embodiments substantially constant tension, is placed on the tissue to hold the tissue layers together. In many of the disclosed embodiments, such adjustment is performed by adjusting the length of the connecting member between the fastening members and/or by providing a means, in many cases associated with a fastener member, for providing a substantially constant tension on the tissue layers. Most of the embodiments shown in FIGS. 10A-10OO include a pair of opposed fastener members connected by a connecting member. It is to be understood that fastener members and connecting members of any embodiment may be used in combination with fastener members and connecting members of other embodiments, as desired.
  • FIG. 10A shows a “T”-shaped [0061] tissue fastener 720 having a first fastening member 721, a connecting member 722, and a second fastening member 723. Member 721 may comprise any suitable biocompatible elongate member, such as a portion of hypodermic tubing. Connecting member 722 may comprise suture material, wire, or any other like biocompatible material that fixedly connects to member 721, preferably in a fashion that permits member 721 to articulate with respect to connecting member 722 for ease of delivery and to the extent needed while implanted. Member 723 may comprise any bead or ball-shaped structure that permits connection to connecting member 722. Member 723 may include a slot therein permitting member 722 to slide through so that the length of member 722 between members 721,723 may be adjusted depending on the thickness of the connected tissue layers. For example, member 723 may be similar to a fishing weight having a slit therein to hold member 722. As an alternative and as shown in FIG. 10A′, member 723 may be a torsion spring 723′ having a pair of arms. When the arms are forced open in the direction of the arrows, connecting member 722 loosens from within spring 723′ and spring 723′ can slide relative to member 722 and be cinched against the tissue layers or an additional member 721. When the arms are released, spring 723′ secures member 722 in position.
  • FIGS. [0062] 10B and 10B′ show a tissue fastener 730 having first fastening member 721, connecting member 722, and a second fastening member 731 having a means for providing a substantially constant force on the tissue layers. In this case, the means includes a flexible bellows-like structure. The bellows of member 731 permit adjustment in the length of connecting member 722 between members 721 and 731. FIG. 10B shows the bellows of member 731 in an expanded, relaxed state. The bellows are contracted during delivery through the esophagus and to the tissue layers. Then, as shown in FIG. 10B′, when fastener 730 is applied to tissue layers 735, the bellows will expand to place a sufficient force against the tissue layers to hold together those layers. In addition, through the use of the bellow-like structure, a substantially constant force is applied to the tissue layers, reducing tissue irritation or loosening of the tissue fastener.
  • FIGS. 10C, 10D, and [0063] 10I show variations on means to maintain constant force on the tissue layers. In FIG. 10C, tissue fastener 740 includes a second fastener member 741 having a spring 742 between two plate-like structures 743, such as disks or buttons. In FIG. 10D, tissue fastener 743 includes a second fastener member 751 having a balloon 752 between the two structures 743. In FIG. 10I, tissue fastener 800 includes a second fastener member 801 having a spring 802. One end of spring 802 connects to structure 743 and the other end of spring 802 is free and places a substantially constant force against the tissue layers. Any suitable, biocompatible, compressible structure may take the place of spring 742, balloon 752, or spring 802.
  • FIG. 10E shows a “double-T” shaped [0064] tissue fastener 760 that is essentially of one-piece construction. Fastener 760 has two opposing fastener members 762, each taking the form of either member 721, member 743, or others described throughout this specification. Members 762 are connected by an elastic connecting member 761 that permits an adjustable length of member 761 between members 762. Member 761 may be made of a elastic, biocompatible material, similar to a rubber-band.
  • FIG. 10H shows a similar arrangement as FIG. 10E. [0065] Fastener 790 includes opposing fastener members 762 interconnected by a bungee cord-like member 792. Member 792 may be pulled tightly (elongated) between members 762 during delivery to the tissue layers and then released so that member 792 shortens and grows in diameter. The growth in diameter may permit an interference fit between member 792 and a hole, notch, slit, or other opening within one or both of the members 762, so that member 792 secures to members 762.
  • In addition to certain embodiments already described, other embodiments include structure associated with one or both fastener members to permit adjustment of the length of the connecting member between the fastener members. For example, FIG. 10F shows a [0066] fastener 770 having first and second fastener members 771, 772 and a connecting member 773. Member 773 includes a plurality of beads, balls, or similar enlarged structures 774 spaced along the length of member 773. As an alternative, the connecting member may include a plurality of notches spaced along the length of the member. The structures may be evenly or unevenly spaced as desired. The structures 774 may be used in combination with a frangible member 772 having a hole that permits structures 774 to travel through the hole to shorten the length of member 773 between members 771, 772. To place more a desired force on the tissue layers, additional structures 774 may be pulled through the hole in member 772. Member 772 may be constructed to include a notch therein to accommodate a structure 774. The through hole in member 772 may be constructed to permit passage of structures 774 in only one direction, i.e. away from member 771 to shorten the length of member 773 between members 771, 772. In addition, member 771 may have a similar construction as member 772 to permit passage of structures 774 therethrough. Excess connecting member 773 may be removed by any suitable method.
  • FIG. 10G shows a [0067] fastener 780 having a fastener member 781 with a ratchet-like mechanism to permit passage of connecting member 782 therethrough in one direction (shown by arrow). Thus, member 781 can move in the direction opposite the arrow to tighten fastener 780 on the tissue layers, with the ratchet-like mechanism preventing loosening of member 782 relative to member 781. Similarly, FIG. 10J shows a fastener 810 having a fastener member 811 with teeth 812 to capture connecting member 813 and prevent loosening. Teeth 812 may be angled in the direction of the applied force to more strongly grasp member 813.
  • FIG. 10K shows a [0068] fastener 820 having a fastener member 821 with a biased locking mechanism 822. The lock 822 includes a ball bearing 823 or like structure contained within a through hole or passage of member 821, and a spring 824 biasing bearing 823 into the passage. Bearing 823 will lock connecting member 825 within the passage when member 825 is not being adjusted in length between the fastener members.
  • Alternative locking mechanisms are shown in FIGS. 10M and 10N. FIG. 10M shows a [0069] locking mechanism 840 that includes a pair of eccentric wheels 841 that rotate to lock connecting member 842 in position after member 842 is adjusted in length between fastener members, similar to eccentric wheel locking mechanisms used on sailboats. Mechanism 840 may be located within one or both fastener members of a fastener. FIG. 10N shows a similar arrangement, having a locking mechanism 850 with eccentric wedges used to lock connecting member 852 in position.
  • FIG. 10L shows a [0070] fastener 830 having a first fastening member 831, a connecting member 832, and a second connecting member 833. Member 833 has a two-piece construction that includes a disk 834 that snaps or otherwise fixedly attaches to a complementary dish-shaped head 835. After connecting member 832 is pulled through a passage in head 835 to adjust the length of member 832 between fastener member 831 and head 835, disk 834 is forced into and attached to head 835, securing member 832 in position.
  • FIGS. 10O and 10P show front views of [0071] exemplary fastener members 860 and 870 respectively. Member 860 includes a wedge-shaped opening 861 therein that accepts a connecting member. Member 871 has a wedge-shaped notch 871 in its side also for accommodating a connecting member. After being pulled taut within tissue and between fastener members, a connecting member may be pulled in the direction of the point of the wedge opening 861 or notch 871 to lock the connecting member in place.
  • FIG. 10Q shows a [0072] fastener 880 having a fastener member 881 having slots around its perimeter that accept connecting member 882. Member 881 may be twisted, as shown by the arrow, so that member 882 wraps around member 881 to adjust the length of member 881 between fastener members 881, 883. When the desired length is achieved, member 882 can lock in a notch or like structure on member 881.
  • FIGS. 10T and 10U show [0073] fasteners 910 and 920 respectively. Fastener 910 includes two dome-shaped fastening members 911 that fully invert in the deployed position (bottom of FIG. 10T) to exert additional force against the tissue layers. Similarly, fastener 920 includes two dome-shaped fastening members 921 that invert in their centers when in the deployed position (bottom of FIG. 10T) to exert additional force against the tissue layers.
  • FIG. 10V shows a [0074] fastener member 930 shaped in a figure eight and having two openings. A connecting member 931 may be adjusted in length between fastening members by winding member 931 around and through the openings, similar to a rappel loop. A small notch in member 930 may hold member 931 once member 930 has been drawn to the desired tension.
  • FIG. 10W shows a [0075] fastener 940 that includes a loop 941 and a connection member 942. Loop 941 may comprise a cable, wire, or other suitable biocompatible material. Loop 941 extends through the tissue layers twice and joins at its ends at connection member 942, which may be located on either side of the tissue layers, through any suitable means. Loop 941 may be tightened and excess loop portions may be excised by cutting or any other suitable method. This embodiment results in a relatively small footprint at the tissue layers.
  • FIG. 10X shows a [0076] fastener member 951 that is a spring clip. Once connecting member 952 is adjusted to the desired tension, spring clip 951 may be inserted over a needle 953 through which connecting member 952 extends (see top portion of FIG. 10X). Spring clip 951 is extended past the distal end of needle 953 to grasp connecting member 952 adjacent tissue layers 954 (see bottom portion of FIG. 10X).
  • The right-hand side of FIG. 10Y shows a deployed [0077] fastener 960 that includes a collet 961 and a C-spring 962. The left-hand side of FIG. 10Y shows collett 961 and C-spring 962 in undeployed positions, i.e. in an open mode. Much like open drill bit chuck, collett 961 can fit over any size connecting member 963. Once collet 961 is in position over connecting member 963 and C-spring 962, or an O-ring or other like structure, is slipped over collet 961, collet 961 closes on member 963. This embodiment permits fastener adjustments.
  • FIG. 10Z shows a [0078] fastener member 971 in both an open position (left-hand side) and a closed position (right-hand side). Member 971 includes a cap 973 with teeth to grip a connector member 972. Cap 973 is held to the remainder of member 971 by a hinge, such as a living hinge. Pulling member 972 opens cap 973 enough to let the connector member 972 adjust. Cap 973 snaps back down to secure member 972. The exit of connecting member 972 from cap 973 could be at a slot or notch at an edge of cap 973.
  • As shown in the variations of FIGS. [0079] 10DD and 10EE (showing end views of alternative fasteners 971 with caps 973′ and 973″ respectively), the exit of connecting member 972 from cap 973′, 973″ could be at a through hole 974 off-center from the fastener hole 975 (FIG. 10DD) or a slot 976 in cap 973 offset from fastener hole 975 (FIG. 10EE). In these alternative embodiments, pulling member 972 to adjust its length will open the cap 973′, 973″ slightly.
  • FIG. 10AA shows a [0080] fastener 980 in the undeployed (left-hand side) and deployed (right-hand side) states. Fastener 980 includes fastener members 981 connected by a connecting member 982. Members 981 have an inward wedge shape that will displace some force to friction along an axis of the connecting member 982. The wedge increases surface area contact of the fastener member 981 with the tissue layers and therefore friction between the layers and the member 981. The wedge portion may include a fabric surface to increase friction. The area of the fabric may be made larger than the surface area of the wedge so that the fabric may bunch up to further increase surface area and friction. A fabric surface or covering may be placed over any suitable fastener member described herein.
  • FIG. 10BB shows a [0081] fastener 990 having a fastener member 991 and a connecting member 992 attached at its ends to fastening members 993. Member 991 may be a pledget or any other suitable member described herein or known in the art. Members 993 may be similar to member 921 described above in connection with FIG. 10A. In FIG. 10BB, member 992 extends through the a tissue layers and member 991 in two places. After deployment of fastener 990, the portion of member 992 extending through member 991 may be twisted (as shown by the arrow) to place desired tension against the tissue layers. Connecting member 992 may be similar to member 722 of FIG. 10A and may be a polymer suture so that ultrasonic or other energy may be used to fuse the twisted portion together by melting.
  • As a variation of the embodiment of FIG. 10BB, FIG. 10CC shows a [0082] fastener 990′ having a suture-like member 992 that extends through member 991 and is formed into a z-like pattern 994 on a surface of member 991 away from the tissue. Member 992 tightens between members 991 and 993 as member 992 is pulled in the direction of the arrows. As a further variation of the embodiment shown in FIG. 10BB, FIG. 10S shows a fastener 900 similar to fastener 990 except that fastener 900 has a one-piece second fastener member 902.
  • FIGS. [0083] 10FF, 10GG, and 10HH show variations of “T”-shaped fastener embodiments. Fastener 1000 includes fastener members 1002 each in the shape of an “H” connected by connecting member 1001. Fastener 1010 includes “T” shaped fastener members 1011 connected by a connecting member that splits into three portions 1012 a, 1012 b, and 1012 c. Fastener 1020 is much like fastener 1010 and includes “T” shaped fastener members 1021 connected by a connecting member that splits into four portions 1022 a, 1022 b, 1022 c, and 1022 d. As with all of the embodiments described herein, any combination of fasteners and connecting members from FIGS. 10FF-10HH may be used to form a suitable fastener.
  • FIG. 10II shows various embodiments of [0084] fasteners 1030, 1040, 1050 that include wire frames as fastener members. The wire frames may be configured in any suitable shape, including triangular, round, and irregular, as shown. It is preferable that the wire frame be collapsible into a flattened shape for ease of delivery and then expand upon deployment.
  • FIG. 10JJ shows embodiments of [0085] fasteners 1055, 1056 having fastener members 1057, 1058 in kite-like configurations. The fastener members 1057, 1058 may include a combination of wire material on the external perimeter portions and suture material as the spokes 1059 extending form the connecting members to the wire perimeter. The fastener members may be configured in any suitable shape, including square, diamond, etc., and, as in the FIG. 10II embodiments, collapse into a flattened shape for delivery and expand upon deployment.
  • FIG. 10KK shows a [0086] fastener 1060 made of a combination of suture material 1061 connecting a pair of hypotubes 1062. the suture material connects to a connecting member 1063 at an approximate midpoint of the fastener 1060. The suture material in the embodiments of FIGS. 10JJ and 10KK, and any other embodiments disclosed herein, may be elastic, fuzzy (like dental floss), and/or swell upon deployment.
  • FIGS. [0087] 10LL-10OO show various embodiments of fasteners designed to have an increased footprint on the tissue layers. When each of these embodiments is used in a fundoplication procedure, a button is placed on the esophageal side of the tissue layers and a mating cup is placed on the stomach side. These arrangements spread force on the tissue layers beyond the button and prevent pull-through in the esophagus. For example, FIG. LL shows a button shaped fastener member 1072 adjacent esophageal tissue 1074 and a mating cup fastener member 1071 adjacent stomach tissue 1075. A connecting member 1073 extends between button 1072 and cup 1071. FIGS. 10MM-10OO show other shaped buttons and mating cups. FIG. 10MM shows fastener 1080 with a convex cup 1082 connected by a connecting member 1083 to a concave mating cup 1081. FIG. 10NN shows fastener 1090 with a wedge-shaped cup 1092 connected by a connecting member 1093 to a corresponding mating cup 1081. FIG. 10OO shows fastener 1100 with a convex cup 1102 connected by a connecting member 1103 to a concave mating cup 1101 surrounded by a flattened area 1104 that further increases the footprint on the tissue layers. Convex, wedge, and other like-shaped buttons increase tissue contact area relative to a flat button arrangement. Other shaped buttons and mating cups may be used.
  • FIG. 10PP shows a [0088] fastener 1110 in a delivered state (top) and a deployed state (bottom). Fastener 1100 is a tube or rod that includes a plurality of slits at ends 1111. Upon deployment at the desired site, the slits at the ends permit the ends to attain a fastener member arrangement having a plurality of arms 1112. Such deployment may be attained through a shape memory material, a deployment mechanism that separates the slits to form arms 1112, or any other suitable method. FIG. 10QQ shows a variation of the fastener embodiment shown in FIG. 10PP. Fastener 1120 includes a pointed, slotted end 1121 that, when deployed, shapes into arms 1122. The pointed end may permit puncturing through the tissue layers. The pointed tip may remain, may be removed through any mechanical, thermal or other suitable method, or may be made of a absorbable material.
  • FIG. 10RR shows a [0089] fastener 1130 that includes a connecting member 1132 with expandable fastener members 1131 at each end. The top portion of FIG. 10RR shows the delivered state in which members 1131 remain in a collapsed configuration, and the bottom view shows members 1131 in a deployed configuration. Members 1131 may be balloons and may be expanded by fluid actuation or any other suitable method. Like fastener 1120, fastener 1130 may be modified to include a pointed tip.
  • FIG. 10SS shows [0090] fasteners 1140 and 1150 having fastener members 1141, 1151 respectively that include non-straight connector pathways. Such pathways create an interference between the connecting member 1142, 1152 and the member 1141, 1151 to aid in securing them together. In the embodiments shown, member 1141 includes a wavy, or serpentine, pathway for member 1142, and member 1151 includes a pathway with a bend. Other non-straight pathways may be used.
  • FIG. 10R shows a [0091] fastener 890 having a plurality of connecting members 891 across the tissue layers to spread the force applied to the tissue surfaces. The connecting members 891 may be unconnected at their ends, or may be connected at their ends to be a single member wrapped around the fastener members 892,893.
  • In further embodiments, friction between the connector member and the fastener members may be increased by a rough surface on the connector member (by for example braiding, knots, fibers), an elastic connecting member, a coated connecting member, or a fabric covered connecting member. In addition, the through hole of the fastener member(s) may include gripping teeth arranged at an angle to prevent reverse movement of the connecting member. Embodiments as appropriate throughout this specification also may include a quick-setting, water tolerant adhesive or glue, such as cyanoacrylate, may be used to pack the passage or hole within a fastening member. [0092]
  • FIGS. 9A through 9J show various other exemplary connecting members according to other embodiments of the present invention. As shown in the figures, a connecting member can be formed of a [0093] telescopic bar 701, a collapsible bellows 702, a cylindrical bar with a ball-socket arrangement 703, a stent-like braided configuration 704, a spiral-shaped spring 705, a webbed spiral spring 706, a crimped structure 707, ratchet 708, elastic member 710, or webbed member 712. In particular, at least the connecting members 701, 702, 705, 706, 710, and 712 shown in FIGS. 9A, 9B, 9E, 9F, 9I, and 9J are configured to be expandable/contractible so as to provide compressive forces to enhance fastening. In an embodiment shown in FIG. 9E, the connecting member 705 is formed of a spiral-shaped spring. As shown in FIG. 9F, the spiral-shaped spring may be covered with a conforming material 706 a, such as, for example, polyurethane, silicone, polytetrafluoroethylene, webbed material or other suitable material. In another embodiment shown in FIG. 9G, the connecting member 707 is configured to be coupled to a fastening member 618. Preferably, a pledget 717 or a ring is utilized to couple between the connecting member 707 and the fastening member 618 to allow moveability of the fastening member 618 along the connecting member 707. In yet another embodiment shown in FIG. 9H, the connecting member 708 includes at least one skirt-like or frustoconical-shaped ratchet 708 a which permits movement only in one direction.
  • FIG. 9I illustrates a post embodiment wherein the post comprises an elastic material. The embodiment of FIG. 9J illustrates a [0094] post 712 comprising a webbed material, for example, a knit or woven material. Any other suitable designs providing the similar function may be utilized.
  • A connecting member [0095] 701-712 is preferably strong enough to maintain its integrity and utility even under stressful events, such as running, swimming, sneezing, coughing, vomiting, or the like. These connecting members 701-712 can provide compressive forces to enhance the fastening of the tissues. In addition, these connecting members 701-712 provide enhanced flexibility for traversing through a tortuous path within a body.
  • Many of the disclosed tissue fasteners, especially those that expand from a contracted, delivered state to an expanded, deployed state, may be made of a shape memory material, such as, for example, nickel titanium alloy (e.g., Nitinol) or a polymer. By utilizing a shape memory material, the fastening member is able to transform from its delivered state to its deployed, functional state automatically upon deployment. Alternatively, the reconfiguration can be obtained by utilizing a material that is reactive to a predetermined condition, e.g., temperature, pH, electrical current, and/or a number of other internal and external stimuli or by its material properties such as elasticity. The expandability of the distal and proximal fastening members can also be obtained by utilizing any suitable mechanical means, such as, for example, a manually actuated expander. [0096]
  • The disclosed tissue fasteners are preferably composed of a biocompatible and biocompliant material, i.e. similar to the compliance of the tissue being connected. The fasteners also may be coated with thrombogenic agents and therapeutics to prevent tissue inflammation. Examples of materials for a tissue fastener, including its coating or covering, include silicone-based polymers, nylon-based polymers, hydrid Teflon-textile based polymers, polypropylene, polyethlylene, or growth factors. Polymer coating materials further include polycarboxylic acids, cellulosic polymers (e.g., cellulose acetate and cellulose nitrate), gelatin, polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone, polyanhydrides (e.g., maleic anhydride polymers), polyamides, polyvinyl alcohols, copolymers of vinyl monomers (e.g., EVA), polyvinyl ethers, polyvinyl aromatics, polyethylene oxides, glycosaminoglycans, polysaccharides, polyesters (polyethylene terephthalate), polyacrylamides, polyethers, polyether sulfone, polycarbonate, polyalkylenes, halogenated polyalkylenes (e.g., polytetrafluoroethylene), polyurethanes, polyorthoesters, proteins, glycoproteins, recombinant proteins, polypeptides, silicones, siloxane polymers, polylactic acid, polyglycolic acid, polycaprolactone, polyhydroxybutyrate valerate and blends and copolymers thereof, coatings from polymer dispersions such as polyurethane dispersions (e.g., BAYHDROL®), fibrin, collagen and its derivatives, polysaccharides (e.g., celluloses, starches, dextrans, alginates and derivatives), hyaluronic acid, and squalene emulsions. Other preferred materials include polyacrylic acid (e.g., HYDROPLUS®), described in U.S. Pat. No. 5,091,205, the disclosure of which is hereby incorporated by reference, and a copolymer of polylactic acid and polycaprolactone. In a preferred embodiment, the fastener comprises a bioabsorbable material. A preferred coating would be one which would minimize tissue inflammation around the fastener. [0097]
  • The disclosed tissue fastener can be made of biodegradable, bioresorbable, and/or bioabsorbable material. The clamping force created by the fastener will induce adhesion formation between the tissue layers. This can occur in a controlled fashion by carefully selecting a material with a predetermined degradation rate. The bioabsorbable material may be formed of cross-linked polymer networks that can be manufactured to be responsive to body temperature, light, pH, and/or a number of other external/internal stimuli. [0098]
  • Deployment of a tissue fastener is discussed below with reference to an exemplary endoluminal deployment system, shown in FIGS. [0099] 11A-C. For illustration purpose, the tissue fastener 1 shown in FIG. 2 is used to illustrate various deployment stages of a tissue fastener, according to an embodiment of the present invention. The deployment system, however, may be used with various other embodiments of tissue fasteners described above. The deployment system 50 includes a flexible overtube 52 configured to accommodate a tissue fastener 1 in a delivered state, and a coupling mechanism 53 for grasping and moving the tissue fastener 1 along the lumen of the overtube 52. The deployment system 50 may also be configured to accommodate multiple tissue fasteners that are stacked axially. The coupling mechanism may be a mechanical grasper 53 that is remotely operable by suitable actuation means at the proximal end (not shown) of the overtube 52. The system 50 also includes a pusher 54 for guiding the tissue fastener along the overtube 52. The pusher 54 may include a hollow lumen through which a cable for operating the grasper 53 passes. The overtube 52 includes a lumen 56 preferably having a diameter capable of accommodating the tissue fastener 1. In at least one embodiment, the overtube 52 may be incorporated into a conventionally known endoluminal fundoplication device, described in U.S. Pat. No. 6,086,600, the disclosure of which is hereby incorporated by reference. A device as taught in that patent may be used to fold the esophageal and fundus walls together, with overtube 52 then used to apply one or more fasteners. The overtube 52 is preferably made of polymer, polymer reinforced with metal, or metal hypotube. The overtube is preferably low in profile and flexible enough to traverse the cricopharyngeal area transorally.
  • FIGS. 18A and 18B show an exemplary embodiment of [0100] deployment system 50, wherein a grasper 53 is fixedly connected to a distal end of a pusher 54. Grasper 53 includes a pair of arms 53′ each terminating in bent hooks 53″. Arms 53′ are elastic and biased in the open position shown in FIG. 18B. During delivery of a tissue fastener, arms 53′ are contracted within overtube 52, ands hooks 53″ mate with a head 11′ of fastener member 11 to hold the fastener to be deployed. When the fastener is deployed and pusher 54 is moved distally so that grasper arms 53′ move past the end of overtube 52, arms 53′ bias to the open position and release member 11. Other suitable coupling methods and devices known in the art for mechanically or otherwise coupling a tissue fastener to a delivery mechanism may be used, such as for example, graspers, pull wires, hooks, elastic couplings, springs, cups, and hypotubes.
  • In another method of detaching a tissue fastener, such as a fastener made of a single wire or any other suitable fastener described in this disclosure, the fastener may be attached to an external mechanism, such as a wire, that runs outside the body. The external wire then may carry the electrical current to electrically detach the fastener when installation of the tissue fastener is complete. Technology known as a Gugliemi Detachable Coil (GDC) or GDC coil detachment, such as that described in U.S. Pat. No. 5,423,829, incorporated by reference herein, may be used in connection with this embodiment. [0101]
  • Referring back to the embodiment shown in FIG. 11B, the [0102] tissue fastener 1 is contained within the flexible overtube 52 and endoluminally delivered to a desired site in a body to protect the body lumen from possible damage caused by the sharp edge 15 of the tissue fastener 1. As shown in FIG. 11B, once the distal end opening 55 of the overtube 52 is placed at the desired site, the tissue fastener 1 is advanced toward the tissue surface, such that the sharp edge 15 of the tissue fastener 1 makes contact with the tissues to be perforated. It should be understood that the tissue fastener may be configured to perforate through the tissue layers, or may be configured to pass through an opening already made by other perforating instruments or the overtube 52. For example, the overtube may include a sheath covering it to puncture through tissue. Once the tissue fastener 1 passes through tissue layers, the distal fastener member 13 is further advanced out of the overtube 52, and the anchor legs 23 are expanded outwardly to form an umbrella-shaped fastening member 13, as shown in FIG. 11C, to hold the tissue layers together.
  • FIGS. 12A through 16 show implantation of a [0103] tissue fastener 1 in a fundoplication procedure, using the endoluminal deployment system shown in FIGS. 11A-11C. The deployment includes performing the delivery and placement of the tissue fastener 1 in essentially one step. As shown in FIG. 12A, the deployment system 50 containing the tissue fastener 1 is transorally inserted into the lower esophagus 3 and positioned adjacent to a desired location near the distal end of the esophagus 3 for the fundoplication procedure.
  • Preferably, prior to the insertion of the endoluminal deployment system into the [0104] esophagus 3, the fundus wall 6 is lifted and folded toward the esophageal wall 4 as shown in FIG. 12A. Any suitable mechanism for lifting the fundus wall 6 toward the esophageal wall 4 may be used for this purpose. An example of such a suitable device is shown and described in U.S. Pat. No. 6,086,600, the entire disclosure of which is incorporated by reference herein. It should also be understood that the lifting device may be formed in combination with the endoluminal deployment system 50.
  • After the distal end opening [0105] 55 of the overtube 52 positioned proximate a desired perforation site of the esophageal wall 4, the tissue fastener 1 is advanced toward the esophageal wall surface, such that the sharp edge 15 of the tissue fastener makes contact with the surface, as illustrated in FIG. 12B Tissue fastener 1 preferably extends out of the overtube 52 only enough so that the edge 15 extends from the opening 55, yet a portion of legs 23 remain in the overtube 52 so that the distal fastening member 13 remains in a contracted state. As discussed above, the tissue fastener 1 may be configured to cut through the esophageal wall 4 and the fundus wall 6, or may be configured to penetrate through an opening already made by other instrument or the overtube 52. As shown in FIG. 13, the overtube 52 with the sharp edge 15 of the tissue fastener 1 protruded out of the overtube 52 is advanced through the esophageal wall 4 and the fundus wall 6.
  • Once the [0106] tissue fastener 1 passes through the layers of esophageal and fundus walls 4, 6, the distal fastening member 13 of the tissue fastener 1 is further advanced out of the overtube 52 causing the anchor legs 23 of the distal fastening member 13 to expand outwardly to form an umbrella-shaped fastening member 13, as shown in FIG. 14. After the distal fastening member 13 is securely placed against the inside fundus wall 6, the overtube 52 is withdrawn and releases the tissue fastener 1 to completely expose the proximal fastening member 11 of the tissue fastener 1. The anchor legs 21 of the proximal fastening member 11 expand outwardly to form the fastening member 11. FIG. 15 is a perspective view of the proximal fastening member 11 of the tissue fastener 1, viewing from inside the esophagus, after the deployment is complete. The distal fastening member 13, i.e., the gastric side, should be robust and resistant to low stomach pH, and the proximal fastening member 11, i.e., esophageal side, should be low in profile to prevent possible lumen occlusion.
  • FIG. 16 is a cross-section view of the [0107] esophageal wall 4 and the fundus wall 6, with a tissue fastener in place, after the fundoplication procedure is complete. The expanded distal and proximal fastener members 13, 11 of the tissue fastener 1 hold and maintain the esophageal and fundus walls 4, 6 together in place to create the fundoplication. The tissue fastener 1 should be strong enough to hold the esophagus and fundus together with a force of approximately 6 lbs without damage to the esophageal wall 4 or fundus wall 6. Furthermore, the tissue fastener 1 should be sufficiently strong enough to maintain its integrity and utility even under stressful events, such as running, swimming, sneezing, coughing, vomiting, or the like. Depending on the type of tissue fasteners used and the desired fastening strength, more than one tissue fastener may be installed. In that instance, a deployment system capable of loading multiple tissue fasteners can be used.
  • The invention is not limited to the exemplary embodiment used to illustrate the deployment of the [0108] tissue fastener 1. Other various tissue fasteners encompassed in this disclosure can be used with the deployment systems and methods described above. Moreover, the disclosed tissue fasteners of the present invention can be used with any other deployment mechanisms conventionally known in the art. In particular, for the tissue fasteners 301, 401 that do not encompass sharp cutting edges, an opening through the esophageal wall 4 and the fundus wall 6 can be made by other piercing instruments, or the endoluminal deployment system 70 having a cutting edge 40 on its distal tip, as shown in FIGS. 17A and 17B.
  • FIGS. 17A and 17B illustrate [0109] endoluminal deployment systems 70 used for the disclosed tissue fasteners, according to still other embodiments of the present invention. Similar to the deployment system 50 shown in FIGS. 10A-C, the deployment system 70 shown in FIGS. 17A and 17B includes a flexible overtube 71 having either a straight or curved distal portion and configured to accommodate a tissue fastener 70 in a contracted state. Fastener 70 is represented with fastening head 74 and connector 72, but this illustration is not intended to limit the possible embodiments. In this embodiment, overtube 71 is represented as a needle. Overtube 71 may be of any size necessary to deploy fastener 71 while working within the confines of anatomical space and instrument space needed to fold and retain the fundus against the esophageal wall. The overtube 71 includes an opening 45 at its distal tip, through which a tissue fastener passes. The opening 45 is defined by a slanted edge to form a sharp cutting edge 40. During deployment, the sharp cutting edge 40 forms an opening through the tissue layers prior to the deployment of a tissue fastener. The fastener 70 is deployed by releasing a fastening head on one side of the tissue layers undergoing attachment and withdrawing overtube 71 from the tissues to release a second fastening head on the opposite tissue layer side.
  • Other devices and methods for delivery and deployment of tissue fasteners disclosed herein may be used. Suitable, exemplary methods and devices are disclosed in U.S. application Ser. No. ______ of Robert Devries et al., filed on the same day as this disclosure, and entitled “Devices and Methods for Fastening Tissue Layers.” The complete disclosure of that application is incorporated by reference herein. [0110]
  • In addition, although the present invention is depicted in this disclosure as being used in the treatment of GERD, e.g., a fundoplication procedure, it is to be understood that the tissue fastener and related deployment methods and systems of the present invention can be used to treat any of a number of different disease conditions, and can be used for fastening any desired body tissues. [0111]
  • Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims. [0112]

Claims (73)

What is claimed is:
1. A tissue fastener used to join multiple tissue layers, comprising:
a proximal member configured to expand from a delivered state to a deployed state;
a distal member configured to expand from a delivered state to a deployed state; and
a connecting member connecting the proximal member to the distal member;
wherein, in the deployed state, the proximal member and the distal member secure the multiple tissue layers together.
2. A tissue fastener according to claim 1, wherein at least one of the proximal member, the distal member, and the connecting member is formed of a shape memory material.
3. A tissue fastener according to claim 1, wherein at least one of the proximal member and the distal member is expanded by mechanical means.
4. A tissue fastener according to claim 1, wherein the tissue fastener is comprised of a biocompatible material.
5. A tissue fastener according to claim 1, wherein the tissue fastener is comprised of a biocompliant material.
6. A tissue fastener according to claim 1, wherein at least one of the proximal member, the distal member, and the connecting member includes a thrombogenic agent.
7. A tissue fastener according to claim 1, wherein at least one of the proximal member, the distal member, and the connecting member includes a coating having a therapeutic agent.
8. A tissue fastener according to claim 7, wherein the therapeutic agent promotes adhesion between the tissues undergoing attachment.
9. A tissue fastener according to claim 1, wherein at least one of the proximal member, the distal member, and the connecting member is formed of bioabsorbable material.
10. A tissue fastener according to claim 1, wherein at least one of the proximal member and the distal member includes a plurality of legs configured to extend outwardly in the deployed state.
11. A tissue fastener according to claim 1, wherein at least one of the proximal member and the distal member includes a plurality of legs each having at least one bending portion proximal to a portion of the leg and wherein the portion of the leg is configured to extend outwardly in the deployed state.
12. A tissue fastener according to claim 1, wherein the distal member includes a sharp edge.
13. A tissue fastener according to claim 1, wherein the distal member comprises a sharp point.
14. A tissue fastener according to claim 1, wherein the proximal member, the distal member, and the connecting member are formed of at least two wires interconnected in a middle portion thereof to form the connecting member.
15. A tissue fastener according to claim 14, wherein each of the wires is essentially straight in the delivered state and bent in the deployed state.
16. A tissue fastener according to claim 1, wherein the proximal member, the distal member, and the connecting member are formed of a single wire.
17. A tissue fastener according to claim 16, wherein the wire is essentially straight in the delivered state and spiral-shaped in the deployed state.
18. A tissue fastener according to claim 16, wherein the wire is essentially straight in the delivered state and includes non-straight portions in the deployed state.
19. A tissue fastener according to claim 1, wherein at least one of the proximal member and the distal member includes a flat surface formed of a shape memory material.
20. A tissue fastener according to claim 1, wherein at least one of the proximal member and the distal member includes a plurality of flexible members that form a cage-like structure in the deployed state.
21. A tissue fastener according to claim 1, wherein at least one of the proximal member and the distal member includes a T-shaped member.
22. A tissue fastener according to claim 1, wherein at least one of the proximal member, the distal member, and the connecting member includes a stent-like structure.
23. A tissue fastener according to claim 1, wherein the connecting member is configured to exert compressive force between the distal member and the proximal member.
24. A tissue fastener according to claim 1, wherein the connecting member is telescopic.
25. A tissue fastener according to claim 1, wherein the connecting member includes a collapsible bellow.
26. A tissue fastener according to claim 1, wherein the connecting member includes a ball-socket arrangement.
27. A tissue fastener according to claim 1, wherein the connecting member includes a braided configuration.
28. A tissue fastener according to claim 1, further comprising a hollow bore passing through at least a portion of the tissue fastener.
29. A tissue fastener according to claim 28, wherein the bore is configured to administer an adhesion promoting agent between tissue layers.
30. A tissue fastener according to claim 1, wherein the tissue fastener has a length sufficient to attach a wall of an esophagus to a wall of a gastric fundus.
31. A delivery system configured for deployment of an expandable tissue fastener, comprising:
a flexible tube having a lumen configured to accommodate a tissue fastener in a contracted state;
a pusher for guiding the tissue fastener along the lumen of the tube; and
a coupling system coupled to a distal end of the pusher and configured to grasp the tissue fastener.
32. A delivery system according to claim 31, further comprising a device for folding two walls of tissue together.
33. A delivery system according to claim 32, wherein the tube is positioned in a lumen of the device.
34. A delivery system according to claim 31, wherein the tube has a length sufficient enough to extend out of a body.
35. A delivery system according to claim 31, wherein the tube includes a sharp cutting edge formed at its distal end.
36. A delivery system according to claim 31, wherein the tube is configured to accommodate multiple tissue fasteners.
37. A delivery system according to claim 31, further comprising actuation means for the coupling system at a proximal end of the tube.
38. A delivery system according to claim 31, wherein the tube has a sheath covering it to puncture through tissue.
39. A delivery system according to claim 38, wherein the sheath includes a puncturing tip.
40. A delivery system according to claim 31, wherein a puncturing tool is delivered through the tube.
41. A method of attaching a first wall of tissue to a second wall of tissue, comprising:
providing an expandable tissue fastener in a contracted state in a device, the tissue fastener having a proximal member and a distal member;
inserting the device into a body passage leading to the first tissue wall;
placing the device proximate a location on the first tissue wall;
passing the device through the first and second tissue walls;
advancing the tissue fastener toward an opening of the device, such that the distal member is completely protruded out of the device and expanded against the second tissue wall; and
releasing the tissue fastener, such that the proximal member is expanded against the first tissue wall.
42. A method according to claim 41, wherein the distal member includes a sharp edge, and further comprising advancing at least a portion of the distal member out of the device, prior to passing the device through the first and second tissue walls.
43. A method according to claim 42, further comprising penetrating the first and second tissue walls with the sharp edge.
44. A method according to claim 41, comprising perforating the first and second tissue walls with a perforating instrument, prior to passing the device through the first and second tissue walls.
45. A method according to claim 41, wherein the passing step includes perforating the first and second tissue walls by a sharp distal end of the device.
46. A method according to claim 41, wherein the first tissue wall is a esophageal wall and the second tissue wall is a gastric fundus wall.
47. A method according to claim 46, further comprising folding the fundus wall proximate to the esophageal wall.
48. A method according to claim 41, wherein the tissue fastener punctures the fundus wall prior to puncturing the esophageal wall.
49. A method according to claim 41, wherein the tissue fastener punctures the fundus wall and the esophageal wall at substantially the same time.
50. A tissue fastener used to join multiple tissue layers, comprising:
a first member;
a second member;
a connecting member connecting the first member to the second member; and
means for applying a substantially constant force on the tissue layers.
51. The tissue fastener of claim 50, wherein the applying means is compressible.
52. The tissue fastener of claim 51, wherein the applying means includes a bellows-like structure.
53. The tissue fastener of claim 51, wherein the applying means includes a spring.
54. The tissue fastener of claim 51, wherein the applying means includes a balloon.
55. The tissue fastener of claim 50, wherein the connecting member includes the applying means, and the applying means is an elongate, elastic member.
56. A tissue fastener used to join multiple tissue layers, comprising:
a first member;
a second member;
a connecting member connecting the first member to the second member; and
means for adjusting a length of the connecting member between the first and second members.
57. The tissue fastener of claim 56, wherein the adjusting means includes structure associated with the first member for releasably securing the connecting member to the first member.
58. The tissue fastener of claim 57, wherein the structure is configured to restrict passage of the connecting member in a direction through the first member.
59. The tissue fastener of claim 58, wherein the structure includes a ratchet-like mechanism.
60. The tissue fastener of claim 58, wherein the structure includes a biased locking mechanism.
61. The tissue fastener of claim 60, wherein the biased locking mechanism includes a spring biasing a bearing.
62. The tissue fastener of claim 58, wherein the structure includes eccentric cams.
63. The tissue fastener of claim 56, wherein the adjusting means includes teeth associated with the first member.
64. The tissue fastener of claim 56, wherein the first member includes the adjusting means, and the adjusting means includes structure for inverting the first member.
65. The tissue fastener of claim 56, wherein rotation of the first member relative to the connecting member adjusts the length of the connecting member between the first and second members.
66. The tissue fastener of claim 65, wherein the adjusting means includes slots on the first member to accommodate the connecting member.
67. The tissue fastener of claim 56, wherein the first member includes the adjusting means, and the adjusting means includes a dish that accommodates a corresponding disk to secure the connecting member therebetween.
68. The tissue fastener of claim 56, wherein the adjusting means includes a notch within the first member to receive the connecting member.
68. The tissue fastener of claim 57, wherein the structure associated with the first member cooperates with connecting member structure to adjust the length of the connecting member.
69. The tissue fastener of claim 68, wherein the connecting member structure includes a plurality of enlargements spaced along the connecting member.
70. The tissue fastener of claim 69, wherein the plurality of enlargements permit incremental adjustments in the length of the connecting member between the first member and the second member.
71. The tissue fastener of claim 57, wherein the structure associated with the first member includes a torsion spring with arms.
72. A tissue fastener used to join multiple tissue layers, comprising:
a first member;
a second member;
a connecting member connecting the first member to the second member;
wherein the connecting member includes a first portion substantially parallel to a second portion, the first and second portions extending between the first and second members and through the first member to connect and form a knot-like configuration against the first member.
US10/230,672 2002-08-29 2002-08-29 Tissue fasteners and related deployment systems and methods Abandoned US20040044364A1 (en)

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US10/230,672 US20040044364A1 (en) 2002-08-29 2002-08-29 Tissue fasteners and related deployment systems and methods
ES03791687T ES2369537T3 (en) 2002-08-29 2003-08-19 FABRIC FIXERS.
EP03791687A EP1530442B1 (en) 2002-08-29 2003-08-19 Tissue fasteners
JP2004532906A JP4456482B2 (en) 2002-08-29 2003-08-19 Tissue fastener and associated deployment system and method
AU2003263892A AU2003263892A1 (en) 2002-08-29 2003-08-19 Tissue fasteners and related deployment systems and methods
AT03791687T ATE526884T1 (en) 2002-08-29 2003-08-19 SURGICAL BRACE
PCT/US2003/025818 WO2004019787A2 (en) 2002-08-29 2003-08-19 Tissue fasteners and related deployment systems and methods
CA002463870A CA2463870A1 (en) 2002-08-29 2003-08-19 Tissue fasteners and related deployment systems and methods
US12/379,252 US8579935B2 (en) 2002-08-29 2009-02-17 Tissue fasteners and related deployment systems and methods
US14/043,255 US20140031841A1 (en) 2002-08-29 2013-10-01 Tissue fasteners and related deployment systems and methods

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Cited By (677)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020161382A1 (en) * 2001-03-29 2002-10-31 Neisz Johann J. Implant inserted without bone anchors
US20030216754A1 (en) * 2002-05-17 2003-11-20 Scout Medical Technologies, Llc Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20040010245A1 (en) * 1999-06-22 2004-01-15 Cerier Jeffrey C. Method and devices for tissue reconfiguration
US20040092892A1 (en) * 2002-11-01 2004-05-13 Jonathan Kagan Apparatus and methods for treatment of morbid obesity
US20040133238A1 (en) * 1999-06-22 2004-07-08 Cerier Jeffrey C. Tissue fixation devices and methods of fixing tissue
US20040193193A1 (en) * 1999-06-22 2004-09-30 Ndo Surgical, Inc., A Massachusetts Corporation Tissue reconfiguration
US20050033328A1 (en) * 1999-06-22 2005-02-10 Ndo Surgical, Inc., A Massachusetts Corporation Methods and devices for tissue reconfiguration
US20050049718A1 (en) * 2002-11-01 2005-03-03 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20050085829A1 (en) * 2002-05-17 2005-04-21 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20050149170A1 (en) * 1998-08-25 2005-07-07 Tassel Robert A.V. Implantable device for promoting repair of a body lumen
US20050177181A1 (en) * 2002-11-01 2005-08-11 Jonathan Kagan Devices and methods for treating morbid obesity
US20050187565A1 (en) * 2004-02-20 2005-08-25 Baker Steve G. Tissue fixation devices and a transoral endoscopic gastroesophageal flap valve restoration device and assembly using same
US20050203550A1 (en) * 2004-03-11 2005-09-15 Laufer Michael D. Surgical fastener
US20050240279A1 (en) * 2002-11-01 2005-10-27 Jonathan Kagan Gastrointestinal sleeve device and methods for treatment of morbid obesity
US6960233B1 (en) * 2002-12-10 2005-11-01 Torax Medical, Inc. Methods and apparatus for improving the function of biological passages
WO2005102181A1 (en) 2004-03-24 2005-11-03 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
US20050251176A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. System for treating gastroesophageal reflux disease
WO2005107608A2 (en) 2004-05-07 2005-11-17 Hubertus Feussner Blind rivet for adapting biological tissue and device for setting the same, in particular through the instrument channel of an endoscope
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US20050277871A1 (en) * 2004-06-11 2005-12-15 Selis James E Biopsy devices and methods
US20050288675A1 (en) * 2004-06-24 2005-12-29 Med Ideas, Llc Disk incision repair method
US20060015125A1 (en) * 2004-05-07 2006-01-19 Paul Swain Devices and methods for gastric surgery
US20060020247A1 (en) * 2002-11-01 2006-01-26 Jonathan Kagan Devices and methods for attaching an endolumenal gastrointestinal implant
US20060025789A1 (en) * 1999-06-22 2006-02-02 Ndo Surgical, Inc., A Massachusetts Corporation Methods and devices for tissue reconfiguration
US20060100640A1 (en) * 2001-11-28 2006-05-11 Aptus Endosystems, Inc. Devices, system, and methods for guiding an operative tool into an interior body region
US20060116754A1 (en) * 2004-11-30 2006-06-01 Robert Thistle Prosthesis fixation device and method
US20060135971A1 (en) * 2004-05-07 2006-06-22 Usgi Medical Inc. System for treating gastroesophageal reflux disease
US20060149316A1 (en) * 2003-12-31 2006-07-06 Boston Scientific Scimed, Inc. Devices and methods for tissue invagination
US20060235469A1 (en) * 2004-10-18 2006-10-19 Viola Frank J Surgical fasteners coated with wound treatment materials
US20060287734A1 (en) * 2001-08-27 2006-12-21 Synecor, Llc Positioning tools and methods for implanting medical devices
US20070010866A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Attachment cuff for gastrointestinal implant
US20070010851A1 (en) * 2003-07-14 2007-01-11 Chanduszko Andrzej J Tubular patent foramen ovale (PFO) closure device with catch system
WO2007004228A1 (en) * 2005-07-06 2007-01-11 Endogun Medical Systems Ltd. Surgical fasteners and fastening devices
WO2007017872A2 (en) * 2005-08-11 2007-02-15 Endogun Medical Systems Ltd. Surgical fasteners and devices for surgical fastening
US20070043255A1 (en) * 2005-08-22 2007-02-22 O'donnell Pat D Surgical instrument for treating female pelvic prolapse
US20070065244A1 (en) * 2003-06-05 2007-03-22 Kabushiki Kaisha Miyanaga Core cutter
US20070083234A1 (en) * 2005-09-21 2007-04-12 Shelton Frederick E Iv Surgical stapling instruments having flexible channel and anvil features for adjustable staple heights
US20070106317A1 (en) * 2005-11-09 2007-05-10 Shelton Frederick E Iv Hydraulically and electrically actuated articulation joints for surgical instruments
US20070102473A1 (en) * 2005-11-09 2007-05-10 Shelton Frederick E Iv Surgical instrument having a hydraulically actuated end effector
US20070194080A1 (en) * 2005-08-31 2007-08-23 Swayze Jeffrey S Surgical stapling device with staple driver that supports multiple wire diameter staples
US20070244518A1 (en) * 2003-07-14 2007-10-18 Nmt Medical, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US20070262116A1 (en) * 2005-08-31 2007-11-15 Hueil Joseph C Surgical stapling device with multiple stacked actuator wedge cams for driving staple drivers
US20070276432A1 (en) * 2003-10-10 2007-11-29 Stack Richard S Devices and Methods for Retaining a Gastro-Esophageal Implant
US20080009886A1 (en) * 2006-07-05 2008-01-10 Wilson-Cook Medical Inc. Suction cup
US20080015635A1 (en) * 2006-06-09 2008-01-17 Daniel Olsen Single disc occlusionary patent foramen ovale closure device
US20080015636A1 (en) * 2006-06-09 2008-01-17 Daniel Olsen Single disc intraluminal patent foramen ovale closure device
US20080058887A1 (en) * 2006-04-25 2008-03-06 Bobby Griffin Methods and devices for gastrointestinal stimulation
WO2008036874A2 (en) * 2006-09-21 2008-03-27 Edwards Scott G System and method of bone compression and fixation
US20080082115A1 (en) * 2006-09-29 2008-04-03 Morgan Jerome R Method of manufacturing staples
US20080195226A1 (en) * 2006-09-02 2008-08-14 Williams Michael S Intestinal sleeves and associated deployment systems and methods
US20080190989A1 (en) * 2005-10-03 2008-08-14 Crews Samuel T Endoscopic plication device and method
US20080208355A1 (en) * 2006-09-15 2008-08-28 Stack Richard S System and method for anchoring stomach implant
US20080228199A1 (en) * 2007-03-16 2008-09-18 Ethicon Endo-Surgery, Inc. Endoscopic tissue approximation method
US20080228202A1 (en) * 2007-03-16 2008-09-18 Ethicon Endo-Surgery, Inc. Endoscopic tissue approximation system
US20080234703A1 (en) * 2007-03-23 2008-09-25 Ethicon Endo-Surgery, Inc. Tissue approximation system
US20080243182A1 (en) * 2007-03-29 2008-10-02 Datascope Investment Corp. Vascular hemostasis device and deployment apparatus
US20080249562A1 (en) * 2007-04-05 2008-10-09 Nmt Medical, Inc. Septal closure device with centering mechanism
US20080275503A1 (en) * 2003-12-23 2008-11-06 Mitralign, Inc. Method of heart valve repair
US20080294179A1 (en) * 2007-05-12 2008-11-27 Balbierz Daniel J Devices and methods for stomach partitioning
US20080306496A1 (en) * 2007-06-08 2008-12-11 Regner Justin L Physiologic abdominal closure
US20080312750A1 (en) * 2006-10-04 2008-12-18 Michael Laufer Methods and devices for reconfiguring a body organ
US20090012553A1 (en) * 2007-06-08 2009-01-08 Valentx, Inc. Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US20090012356A1 (en) * 2007-06-11 2009-01-08 Valen Tx, Inc. Endoscopic delivery devices and methods
US20090012544A1 (en) * 2007-06-08 2009-01-08 Valen Tx, Inc. Gastrointestinal bypass sleeve as an adjunct to bariatric surgery
US20090024143A1 (en) * 2007-07-18 2009-01-22 Crews Samuel T Endoscopic implant system and method
US20090030284A1 (en) * 2007-07-18 2009-01-29 David Cole Overtube introducer for use in endoscopic bariatric surgery
EP2033584A1 (en) 2007-09-10 2009-03-11 Olympus Medical Systems Corporation Tissue fastening tool, stent and applicator for indweling the same within body, and tissue fastening method through natural orifice
US20090088795A1 (en) * 2007-09-28 2009-04-02 Nmt Medical, Inc. Catch Member for Septal Occluder with Adjustable-Length Center Joint
US20090099650A1 (en) * 2001-11-28 2009-04-16 Lee Bolduc Devices, systems, and methods for endovascular staple and/or prosthesis delivery and implantation
US20090105816A1 (en) * 2007-10-19 2009-04-23 Olsen Daniel H System using a helical retainer in the direct plication annuloplasty treatment of mitral valve regurgitation
US20090125040A1 (en) * 2006-09-13 2009-05-14 Hambly Pablo R Tissue acquisition devices and methods
US20090171383A1 (en) * 2007-12-31 2009-07-02 David Cole Gastric space occupier systems and methods of use
US20090204145A1 (en) * 2008-02-12 2009-08-13 Cook Incorporated Spiral occluding device with an occlusion sail
US20090206136A1 (en) * 2008-02-14 2009-08-20 Ethicon Endo-Surgery, Inc. Disposable motor-driven loading unit for use with a surgical cutting and stapling apparatus
US20090236390A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US20090259235A1 (en) * 2008-04-11 2009-10-15 Genevieve Doucet Surgical fastener for attaching a hernia prosthesis
US20090270912A1 (en) * 2008-04-23 2009-10-29 Wilson-Cook Medical Inc. Tacking device
US20090270887A1 (en) * 2003-05-09 2009-10-29 Tyco Healthcare Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
US20090281568A1 (en) * 2006-06-14 2009-11-12 Juan Carlos Cendan Devices and Methods for Adjustable, Knotless Tissue Approximation
US7632287B2 (en) 2004-02-20 2009-12-15 Endogastric Solutions, Inc. Tissue fixation devices and assemblies for deploying the same
US20100016988A1 (en) * 2001-08-27 2010-01-21 Stack Richard S Satiation devices and methods
US20100049208A1 (en) * 2008-08-19 2010-02-25 Wilson-Cook Medical Inc. Apparatus and methods for removing lymph nodes or anchoring into tissue during a translumenal procedure
US7669746B2 (en) 2005-08-31 2010-03-02 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US7669747B2 (en) 2007-03-15 2010-03-02 Ethicon Endo-Surgery, Inc. Washer for use with a surgical stapling instrument
WO2010030778A1 (en) * 2008-09-11 2010-03-18 Wilson-Cook Medical Inc. Methods for achieving serosa-to-serosa closure of a bodily opening using one or more tacking devices
US20100069955A1 (en) * 2008-09-11 2010-03-18 Wilson-Cook Medical Inc. Methods for facilitating closure of a bodily opening using one or more tacking devices
US20100076408A1 (en) * 2007-10-19 2010-03-25 Matthew Krever Deflecting guide catheter for use in a minimally invasive medical procedure for the treatment of mitral valve regurgitation
US20100089970A1 (en) * 2008-10-10 2010-04-15 Ethicon Endo-Surgery, Inc. Powered surgical cutting and stapling apparatus with manually retractable firing system
US20100100109A1 (en) * 2002-04-08 2010-04-22 Stack Richard S Method and apparatus for modifying the exit orifice of a satiation pouch
US20100106168A1 (en) * 2002-08-01 2010-04-29 Selis James E Biopsy devices and methods
US20100116867A1 (en) * 2008-11-10 2010-05-13 Balbierz Daniel J Multi-fire stapling systems and methods for delivering arrays of staples
US20100121370A1 (en) * 2008-11-11 2010-05-13 Aga Medical Corporation Asymmetrical medical devices for treating a target site and associated method
US20100145382A1 (en) * 2003-07-14 2010-06-10 Nmt Medical, Inc. Tubular patent foramen ovale (pfo) closure device with catch system
US20100145362A1 (en) * 2008-12-09 2010-06-10 Wilson-Cook Medical Inc. Apparatus and methods for controlled release of tacking devices
US20100160935A1 (en) * 2008-12-19 2010-06-24 Wilson-Cook Medical Inc. Clip devices and methods of delivery and deployment
US20100160931A1 (en) * 2008-12-19 2010-06-24 Wilson-Cook Medical Inc. Variable thickness tacking devices and methods of delivery and deployment
US20100168507A1 (en) * 2005-08-12 2010-07-01 Kraemer Stefan J M Apparatus and method for securing the stomach to the diaphragm for use, for example, in treating hiatal hernias and gastroesophageal reflux disease
US20100262169A1 (en) * 2005-01-25 2010-10-14 Baker Steve G Slitted tissue fixation devices and assemblies for deploying the same
US7819296B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with retractable firing systems
US7819298B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
US7819297B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with reprocessible handle assembly
US20100280529A1 (en) * 2009-05-04 2010-11-04 Barosense, Inc. Endoscopic implant system and method
US20100276469A1 (en) * 2009-05-01 2010-11-04 Barosense, Inc. Plication tagging device and method
US20100305591A1 (en) * 2009-05-28 2010-12-02 Wilson-Cook Medical Inc. Tacking device and methods of deployment
US20100327042A1 (en) * 2008-03-14 2010-12-30 Amid Parviz K Hernia stapler with integrated mesh manipulator
US7861906B2 (en) 2008-02-14 2011-01-04 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with articulatable components
US7866527B2 (en) 2008-02-14 2011-01-11 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US20110087320A1 (en) * 2001-11-28 2011-04-14 Aptus Endosystems, Inc. Devices, Systems, and Methods for Prosthesis Delivery and Implantation, Including a Prosthesis Assembly
US7934630B2 (en) 2005-08-31 2011-05-03 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US20110124963A1 (en) * 2002-08-29 2011-05-26 Boston Scientific Scimed, Inc. (formerly, Scimed Life Systems, Inc.) Devices and methods for fastening tissue layers
US20110174860A1 (en) * 2006-01-31 2011-07-21 Ethicon Endo-Surgery, Inc. Surgical instrument with force-feedback capabilities
US8029455B2 (en) 2003-01-16 2011-10-04 Barosense, Inc. Satiation pouches and methods of use
US8161977B2 (en) 2006-01-31 2012-04-24 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US8186555B2 (en) 2006-01-31 2012-05-29 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with mechanical closure system
US8196796B2 (en) 2007-06-04 2012-06-12 Ethicon Endo-Surgery, Inc. Shaft based rotary drive system for surgical instruments
US8206280B2 (en) 2007-11-13 2012-06-26 C. R. Bard, Inc. Adjustable tissue support member
US8206456B2 (en) 2003-10-10 2012-06-26 Barosense, Inc. Restrictive and/or obstructive implant system for inducing weight loss
US8241202B2 (en) 2004-04-26 2012-08-14 Barosense, Inc. Restrictive and/or obstructive implant for inducing weight loss
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US20120283758A1 (en) * 2011-01-11 2012-11-08 Arnold Miller Method and apparatus for treating varicose veins
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8397971B2 (en) 2009-02-05 2013-03-19 Ethicon Endo-Surgery, Inc. Sterilizable surgical instrument
US8414577B2 (en) 2009-02-05 2013-04-09 Ethicon Endo-Surgery, Inc. Surgical instruments and components for use in sterile environments
US8424740B2 (en) 2007-06-04 2013-04-23 Ethicon Endo-Surgery, Inc. Surgical instrument having a directional switching mechanism
US20130110228A1 (en) * 2007-06-08 2013-05-02 St. Jude Medical, Inc Devices for transcatheter prosthetic heart valve implantation and access closure
US20130138149A1 (en) * 2011-11-28 2013-05-30 St. Jude Medical Puerto Rico Llc Large bore anchor device
US8459525B2 (en) 2008-02-14 2013-06-11 Ethicon Endo-Sugery, Inc. Motorized surgical cutting and fastening instrument having a magnetic drive train torque limiting device
US8459520B2 (en) 2007-01-10 2013-06-11 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and remote sensor
US8460371B2 (en) 2002-10-21 2013-06-11 Mitralign, Inc. Method and apparatus for performing catheter-based annuloplasty using local plications
US8469977B2 (en) 2005-10-03 2013-06-25 Barosense, Inc. Endoscopic plication device and method
US8480559B2 (en) 2006-09-13 2013-07-09 C. R. Bard, Inc. Urethral support system
US8479969B2 (en) 2007-01-10 2013-07-09 Ethicon Endo-Surgery, Inc. Drive interface for operably coupling a manipulatable surgical tool to a robot
US8500760B2 (en) 2008-12-09 2013-08-06 Cook Medical Technologies Llc Retractable tacking device
US8529600B2 (en) 2010-09-30 2013-09-10 Ethicon Endo-Surgery, Inc. Fastener system comprising a retention matrix
US8534528B2 (en) 2007-06-04 2013-09-17 Ethicon Endo-Surgery, Inc. Surgical instrument having a multiple rate directional switching mechanism
US8540128B2 (en) 2007-01-11 2013-09-24 Ethicon Endo-Surgery, Inc. Surgical stapling device with a curved end effector
US8573465B2 (en) 2008-02-14 2013-11-05 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical end effector system with rotary actuated closure systems
US8573461B2 (en) 2008-02-14 2013-11-05 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with cam-driven staple deployment arrangements
US8584919B2 (en) 2008-02-14 2013-11-19 Ethicon Endo-Sugery, Inc. Surgical stapling apparatus with load-sensitive firing mechanism
US8602288B2 (en) 2008-09-23 2013-12-10 Ethicon Endo-Surgery. Inc. Robotically-controlled motorized surgical end effector system with rotary actuated closure systems having variable actuation speeds
US8602287B2 (en) 2008-09-23 2013-12-10 Ethicon Endo-Surgery, Inc. Motor driven surgical cutting instrument
US8616431B2 (en) 2007-06-04 2013-12-31 Ethicon Endo-Surgery, Inc. Shiftable drive interface for robotically-controlled surgical tool
US8622274B2 (en) 2008-02-14 2014-01-07 Ethicon Endo-Surgery, Inc. Motorized cutting and fastening instrument having control circuit for optimizing battery usage
US8636736B2 (en) 2008-02-14 2014-01-28 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument
US20140031631A1 (en) * 2009-02-06 2014-01-30 Gregory W. HALL Method and Apparatus for Inducing Therapeutic Hypothermia
US8652120B2 (en) 2007-01-10 2014-02-18 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US8657174B2 (en) 2008-02-14 2014-02-25 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument having handle based power source
US8726909B2 (en) 2006-01-27 2014-05-20 Usgi Medical, Inc. Methods and apparatus for revision of obesity procedures
US8740038B2 (en) 2010-09-30 2014-06-03 Ethicon Endo-Surgery, Inc. Staple cartridge comprising a releasable portion
US8747238B2 (en) 2012-06-28 2014-06-10 Ethicon Endo-Surgery, Inc. Rotary drive shaft assemblies for surgical instruments with articulatable end effectors
US8753359B2 (en) 2008-02-18 2014-06-17 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8752749B2 (en) 2008-02-14 2014-06-17 Ethicon Endo-Surgery, Inc. Robotically-controlled disposable motor-driven loading unit
US20140171733A1 (en) * 2011-07-11 2014-06-19 Tel Hashomer Medical Research Infrastructure And Services Ltd. Body part repositioning apparatus and method
US8758391B2 (en) 2008-02-14 2014-06-24 Ethicon Endo-Surgery, Inc. Interchangeable tools for surgical instruments
US8763879B2 (en) 2006-01-31 2014-07-01 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of surgical instrument
US8783541B2 (en) 2003-05-20 2014-07-22 Frederick E. Shelton, IV Robotically-controlled surgical end effector system
EP2756794A1 (en) * 2005-02-08 2014-07-23 Koninklijke Philips N.V. System and method for percutaneous glossoplasty
US8790356B2 (en) 2010-06-09 2014-07-29 C.R. Bard, Inc. Instruments for delivering transfascial sutures, transfascial suture assemblies, and methods of transfascial suturing
US8789741B2 (en) 2010-09-24 2014-07-29 Ethicon Endo-Surgery, Inc. Surgical instrument with trigger assembly for generating multiple actuation motions
US8800838B2 (en) 2005-08-31 2014-08-12 Ethicon Endo-Surgery, Inc. Robotically-controlled cable-based surgical end effectors
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8820603B2 (en) 2006-01-31 2014-09-02 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US8845512B2 (en) 2005-11-14 2014-09-30 C. R. Bard, Inc. Sling anchor system
US8844789B2 (en) 2006-01-31 2014-09-30 Ethicon Endo-Surgery, Inc. Automated end effector component reloading system for use with a robotic system
US8845723B2 (en) 2007-03-13 2014-09-30 Mitralign, Inc. Systems and methods for introducing elements into tissue
US8852216B2 (en) 2007-03-23 2014-10-07 Ethicon Endo-Surgery, Inc. Tissue approximation methods
US8864822B2 (en) 2003-12-23 2014-10-21 Mitralign, Inc. Devices and methods for introducing elements into tissue
US8870049B2 (en) 2008-03-14 2014-10-28 Transenterix, Inc. Hernia stapler
US8888811B2 (en) 2008-10-20 2014-11-18 Covidien Lp Device and method for attaching an implant to biological tissue
US8893946B2 (en) 2007-03-28 2014-11-25 Ethicon Endo-Surgery, Inc. Laparoscopic tissue thickness and clamp load measuring devices
US8893949B2 (en) 2010-09-30 2014-11-25 Ethicon Endo-Surgery, Inc. Surgical stapler with floating anvil
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
US8911461B2 (en) 2007-03-13 2014-12-16 Mitralign, Inc. Suture cutter and method of cutting suture
US8911471B2 (en) 2006-03-23 2014-12-16 Ethicon Endo-Surgery, Inc. Articulatable surgical device
US8926634B2 (en) 2004-05-07 2015-01-06 Usgi Medical, Inc. Apparatus and methods for manipulating and securing tissue
US8951286B2 (en) 2005-07-05 2015-02-10 Mitralign, Inc. Tissue anchor and anchoring system
US8956318B2 (en) 2012-05-31 2015-02-17 Valentx, Inc. Devices and methods for gastrointestinal bypass
US8979923B2 (en) 2002-10-21 2015-03-17 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
US9005241B2 (en) 2008-02-18 2015-04-14 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US9005230B2 (en) 2008-09-23 2015-04-14 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US9028519B2 (en) 2008-09-23 2015-05-12 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US9028494B2 (en) 2012-06-28 2015-05-12 Ethicon Endo-Surgery, Inc. Interchangeable end effector coupling arrangement
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US9044230B2 (en) 2012-02-13 2015-06-02 Ethicon Endo-Surgery, Inc. Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US9050084B2 (en) 2011-09-23 2015-06-09 Ethicon Endo-Surgery, Inc. Staple cartridge including collapsible deck arrangement
US9055941B2 (en) 2011-09-23 2015-06-16 Ethicon Endo-Surgery, Inc. Staple cartridge including collapsible deck
US9072535B2 (en) 2011-05-27 2015-07-07 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with rotatable staple deployment arrangements
US9072536B2 (en) 2012-06-28 2015-07-07 Ethicon Endo-Surgery, Inc. Differential locking arrangements for rotary powered surgical instruments
US9101385B2 (en) 2012-06-28 2015-08-11 Ethicon Endo-Surgery, Inc. Electrode connections for rotary driven surgical tools
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
US9107727B2 (en) 2001-08-27 2015-08-18 Boston Scientific Scimed, Inc. Satiation devices and methods
US9119657B2 (en) 2012-06-28 2015-09-01 Ethicon Endo-Surgery, Inc. Rotary actuatable closure arrangement for surgical end effector
US9125662B2 (en) 2012-06-28 2015-09-08 Ethicon Endo-Surgery, Inc. Multi-axis articulating and rotating surgical tools
US9138225B2 (en) 2007-06-22 2015-09-22 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with an articulatable end effector
WO2015143366A1 (en) 2014-03-21 2015-09-24 Boston Scientific Scimed, Inc. Devices and methods for lumen occlusion
EP2856950A3 (en) * 2013-08-13 2015-10-07 Cook Medical Technologies LLC Double baffle vascular occluder
US9198662B2 (en) 2012-03-28 2015-12-01 Ethicon Endo-Surgery, Inc. Tissue thickness compensator having improved visibility
US9204880B2 (en) 2012-03-28 2015-12-08 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising capsules defining a low pressure environment
US9204879B2 (en) 2012-06-28 2015-12-08 Ethicon Endo-Surgery, Inc. Flexible drive member
US9211120B2 (en) 2011-04-29 2015-12-15 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a plurality of medicaments
US9220501B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensators
US9220500B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising structure to produce a resilient load
US9226751B2 (en) 2012-06-28 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical instrument system including replaceable end effectors
US9232941B2 (en) 2010-09-30 2016-01-12 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a reservoir
US9237891B2 (en) 2005-08-31 2016-01-19 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US9272406B2 (en) 2010-09-30 2016-03-01 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a cutting member for releasing a tissue thickness compensator
US9282966B2 (en) 2004-07-28 2016-03-15 Ethicon Endo-Surgery, Inc. Surgical stapling instrument
US9282974B2 (en) 2012-06-28 2016-03-15 Ethicon Endo-Surgery, Llc Empty clip cartridge lockout
US9283054B2 (en) 2013-08-23 2016-03-15 Ethicon Endo-Surgery, Llc Interactive displays
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9301752B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising a plurality of capsules
US9307989B2 (en) 2012-03-28 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorportating a hydrophobic agent
US9307986B2 (en) 2013-03-01 2016-04-12 Ethicon Endo-Surgery, Llc Surgical instrument soft stop
US9314246B2 (en) 2010-09-30 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent
US20160106420A1 (en) * 2013-06-28 2016-04-21 Valcare, Inc. Device, system, and method to secure an article to a tissue
US9320521B2 (en) 2006-06-27 2016-04-26 Ethicon Endo-Surgery, Llc Surgical instrument
US9320523B2 (en) 2012-03-28 2016-04-26 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising tissue ingrowth features
US9320589B2 (en) 2001-11-28 2016-04-26 Medtronic Vascular, Inc. Endovascular aneurysm repair system
US9332974B2 (en) 2010-09-30 2016-05-10 Ethicon Endo-Surgery, Llc Layered tissue thickness compensator
US9332987B2 (en) 2013-03-14 2016-05-10 Ethicon Endo-Surgery, Llc Control arrangements for a drive member of a surgical instrument
US9332984B2 (en) 2013-03-27 2016-05-10 Ethicon Endo-Surgery, Llc Fastener cartridge assemblies
US9345481B2 (en) 2013-03-13 2016-05-24 Ethicon Endo-Surgery, Llc Staple cartridge tissue thickness sensor system
US9358005B2 (en) 2010-09-30 2016-06-07 Ethicon Endo-Surgery, Llc End effector layer including holding features
US9358112B2 (en) 2001-04-24 2016-06-07 Mitralign, Inc. Method and apparatus for catheter-based annuloplasty using local plications
US9364233B2 (en) 2010-09-30 2016-06-14 Ethicon Endo-Surgery, Llc Tissue thickness compensators for circular surgical staplers
US9386984B2 (en) 2013-02-08 2016-07-12 Ethicon Endo-Surgery, Llc Staple cartridge comprising a releasable cover
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9393015B2 (en) 2009-02-06 2016-07-19 Ethicon Endo-Surgery, Llc Motor driven surgical fastener device with cutting member reversing mechanism
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
EP2882351A4 (en) * 2012-08-10 2016-08-03 Gore & Ass Microanchors for anchoring devices to body tissues
US9421006B2 (en) 2007-01-08 2016-08-23 Endogastric Solutions, Inc. Connected fasteners, delivery device and method
US20160270785A1 (en) * 2010-05-21 2016-09-22 Boston Scientific Scimed, Inc. Tissue-acquisition and fastening devices and methods
US9451960B2 (en) 2012-05-31 2016-09-27 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9474517B2 (en) 2008-03-07 2016-10-25 W. L. Gore & Associates, Inc. Heart occlusion devices
US9486214B2 (en) 2009-02-06 2016-11-08 Ethicon Endo-Surgery, Llc Motor driven surgical fastener device with switching system configured to prevent firing initiation until activated
US9526500B2 (en) 2004-11-30 2016-12-27 Endogastric Solutions, Inc. Flexible transoral endoscopic gastroesophageal flap valve restoration device and method
US9549735B2 (en) 2013-12-23 2017-01-24 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a firing member including fastener transfer surfaces
US9561038B2 (en) 2012-06-28 2017-02-07 Ethicon Endo-Surgery, Llc Interchangeable clip applier
US9574644B2 (en) 2013-05-30 2017-02-21 Ethicon Endo-Surgery, Llc Power module for use with a surgical instrument
US9572577B2 (en) 2013-03-27 2017-02-21 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a tissue thickness compensator including openings therein
US9572571B2 (en) 2011-09-09 2017-02-21 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US9585657B2 (en) 2008-02-15 2017-03-07 Ethicon Endo-Surgery, Llc Actuator for releasing a layer of material from a surgical end effector
US9603991B2 (en) 2004-07-28 2017-03-28 Ethicon Endo-Surgery, Llc Surgical stapling instrument having a medical substance dispenser
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US9642620B2 (en) 2013-12-23 2017-05-09 Ethicon Endo-Surgery, Llc Surgical cutting and stapling instruments with articulatable end effectors
US9649110B2 (en) 2013-04-16 2017-05-16 Ethicon Llc Surgical instrument comprising a closing drive and a firing drive operated from the same rotatable output
US9675489B2 (en) 2012-05-31 2017-06-13 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9675360B2 (en) 2005-10-18 2017-06-13 Endogastric Solutions, Inc. Invaginator for gastroesophageal flap valve restoration device
US9681870B2 (en) 2013-12-23 2017-06-20 Ethicon Llc Articulatable surgical instruments with separate and distinct closing and firing systems
US9690362B2 (en) 2014-03-26 2017-06-27 Ethicon Llc Surgical instrument control circuit having a safety processor
US9693777B2 (en) 2014-02-24 2017-07-04 Ethicon Llc Implantable layers comprising a pressed region
EP3060172A4 (en) * 2013-10-23 2017-07-05 LC Therapeutics, Inc. Percutaneous or minimally invasive cardiac valve repair system and methods of using the same
US9724092B2 (en) 2013-12-23 2017-08-08 Ethicon Llc Modular surgical instruments
US9724098B2 (en) 2012-03-28 2017-08-08 Ethicon Endo-Surgery, Llc Staple cartridge comprising an implantable layer
US9724094B2 (en) 2014-09-05 2017-08-08 Ethicon Llc Adjunct with integrated sensors to quantify tissue compression
US9743928B2 (en) 2006-01-31 2017-08-29 Ethicon Endo-Surgery, Inc. Surgical instrument having a feedback system
US9743929B2 (en) 2014-03-26 2017-08-29 Ethicon Llc Modular powered surgical instrument with detachable shaft assemblies
US9757264B2 (en) 2013-03-13 2017-09-12 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9795384B2 (en) 2013-03-27 2017-10-24 Ethicon Llc Fastener cartridge comprising a tissue thickness compensator and a gap setting element
US9795382B2 (en) 2005-08-31 2017-10-24 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US9801627B2 (en) 2014-09-26 2017-10-31 Ethicon Llc Fastener cartridge for creating a flexible staple line
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US9808246B2 (en) 2015-03-06 2017-11-07 Ethicon Endo-Surgery, Llc Method of operating a powered surgical instrument
US9808250B2 (en) 2001-11-28 2017-11-07 Medtronic Vascular, Inc. Systems and methods for attaching a prosthesis within a body lumen or hollow organ
US9814462B2 (en) 2010-09-30 2017-11-14 Ethicon Llc Assembly for fastening tissue comprising a compressible layer
US9820738B2 (en) 2014-03-26 2017-11-21 Ethicon Llc Surgical instrument comprising interactive systems
US9826972B2 (en) 2011-10-24 2017-11-28 C.R. Bard, Inc. Instruments for delivering transfascial sutures, transfascial suture assemblies and methods of transfascial suturing
US9826978B2 (en) 2010-09-30 2017-11-28 Ethicon Llc End effectors with same side closure and firing motions
WO2017203523A1 (en) * 2016-05-23 2017-11-30 Mor Research Applications Ltd. Anastomosis device
US9833241B2 (en) 2014-04-16 2017-12-05 Ethicon Llc Surgical fastener cartridges with driver stabilizing arrangements
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9839428B2 (en) 2013-12-23 2017-12-12 Ethicon Llc Surgical cutting and stapling instruments with independent jaw control features
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US9861360B2 (en) 2011-09-09 2018-01-09 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US9861359B2 (en) 2006-01-31 2018-01-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US9888926B2 (en) 2009-05-29 2018-02-13 Boston Scientific Scimed, Inc. Apparatus and method for deploying stent across adjacent tissue layers
US20180042607A1 (en) * 2015-08-11 2018-02-15 Amsel Medical Corporation Apparatus and Methods for Clamping Tissue Layers and Occluding Hollow Vessels
US9895148B2 (en) 2015-03-06 2018-02-20 Ethicon Endo-Surgery, Llc Monitoring speed control and precision incrementing of motor for powered surgical instruments
US9901342B2 (en) 2015-03-06 2018-02-27 Ethicon Endo-Surgery, Llc Signal and power communication system positioned on a rotatable shaft
US9913642B2 (en) 2014-03-26 2018-03-13 Ethicon Llc Surgical instrument comprising a sensor system
US9924961B2 (en) 2015-03-06 2018-03-27 Ethicon Endo-Surgery, Llc Interactive feedback system for powered surgical instruments
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US9931118B2 (en) 2015-02-27 2018-04-03 Ethicon Endo-Surgery, Llc Reinforced battery for a surgical instrument
US9943309B2 (en) 2014-12-18 2018-04-17 Ethicon Llc Surgical instruments with articulatable end effectors and movable firing beam support arrangements
US9955957B2 (en) 2011-09-09 2018-05-01 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
US9968353B2 (en) 2001-06-04 2018-05-15 Medtronic Vascular, Inc. Catheter based fastener implantation apparatus and methods
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US9987118B2 (en) 2005-12-01 2018-06-05 Endogastric Solutions, Inc. Apparatus and method for concurrently forming a gastroesophageal valve and tightening the lower esophageal sphincter
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
US9993258B2 (en) 2015-02-27 2018-06-12 Ethicon Llc Adaptable surgical instrument handle
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device
US10004498B2 (en) 2006-01-31 2018-06-26 Ethicon Llc Surgical instrument comprising a plurality of articulation joints
USD822206S1 (en) 2016-06-24 2018-07-03 Ethicon Llc Surgical fastener
US10028744B2 (en) 2015-08-26 2018-07-24 Ethicon Llc Staple cartridge assembly including staple guides
US10045776B2 (en) 2015-03-06 2018-08-14 Ethicon Llc Control techniques and sub-processor contained within modular shaft with select control processing from handle
US10045781B2 (en) 2014-06-13 2018-08-14 Ethicon Llc Closure lockout systems for surgical instruments
US10052044B2 (en) 2015-03-06 2018-08-21 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
USD826405S1 (en) 2016-06-24 2018-08-21 Ethicon Llc Surgical fastener
US10052102B2 (en) 2015-06-18 2018-08-21 Ethicon Llc Surgical end effectors with dual cam actuated jaw closing features
US10076325B2 (en) 2014-10-13 2018-09-18 Ethicon Llc Surgical stapling apparatus comprising a tissue stop
US10076330B2 (en) 2008-05-12 2018-09-18 Xlumena, Inc. Tissue anchor for securing tissue layers
US10076326B2 (en) 2015-09-23 2018-09-18 Ethicon Llc Surgical stapler having current mirror-based motor control
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US10085751B2 (en) 2015-09-23 2018-10-02 Ethicon Llc Surgical stapler having temperature-based motor control
US10092292B2 (en) 2013-02-28 2018-10-09 Ethicon Llc Staple forming features for surgical stapling instrument
US10098770B2 (en) 2001-11-28 2018-10-16 Medtronic Vascular, Inc. Endovascular aneurysm devices, systems, and methods
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10117649B2 (en) 2014-12-18 2018-11-06 Ethicon Llc Surgical instrument assembly comprising a lockable articulation system
US10130359B2 (en) 2006-09-29 2018-11-20 Ethicon Llc Method for forming a staple
US10172620B2 (en) 2015-09-30 2019-01-08 Ethicon Llc Compressible adjuncts with bonding nodes
US10172619B2 (en) 2015-09-02 2019-01-08 Ethicon Llc Surgical staple driver arrays
US10180463B2 (en) 2015-02-27 2019-01-15 Ethicon Llc Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band
US10188385B2 (en) 2014-12-18 2019-01-29 Ethicon Llc Surgical instrument system comprising lockable systems
US10194905B2 (en) 2001-11-28 2019-02-05 Medtronic Vascular, Inc. Devices, systems, and methods for endovascular staple and/or prosthesis delivery and implantation
US10206676B2 (en) 2008-02-14 2019-02-19 Ethicon Llc Surgical cutting and fastening instrument
US10211586B2 (en) 2017-06-28 2019-02-19 Ethicon Llc Surgical shaft assemblies with watertight housings
US10213201B2 (en) 2015-03-31 2019-02-26 Ethicon Llc Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw
US10226249B2 (en) 2013-03-01 2019-03-12 Ethicon Llc Articulatable surgical instruments with conductive pathways for signal communication
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US10245029B2 (en) 2016-02-09 2019-04-02 Ethicon Llc Surgical instrument with articulating and axially translatable end effector
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US10258336B2 (en) 2008-09-19 2019-04-16 Ethicon Llc Stapling system configured to produce different formed staple heights
US10258418B2 (en) 2017-06-29 2019-04-16 Ethicon Llc System for controlling articulation forces
US10258331B2 (en) 2016-02-12 2019-04-16 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
US10271849B2 (en) 2015-09-30 2019-04-30 Ethicon Llc Woven constructs with interlocked standing fibers
USD847989S1 (en) 2016-06-24 2019-05-07 Ethicon Llc Surgical fastener cartridge
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
USD850617S1 (en) 2016-06-24 2019-06-04 Ethicon Llc Surgical fastener cartridge
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
USD851762S1 (en) 2017-06-28 2019-06-18 Ethicon Llc Anvil
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US10327793B2 (en) 2005-06-29 2019-06-25 Endogastric Solutions, Inc. Apparatus and method for manipulating stomach tissue and treating gastroesophageal reflux disease
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
USD854151S1 (en) 2017-06-28 2019-07-16 Ethicon Llc Surgical instrument shaft
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10363037B2 (en) 2016-04-18 2019-07-30 Ethicon Llc Surgical instrument system comprising a magnetic lockout
US10363036B2 (en) 2015-09-23 2019-07-30 Ethicon Llc Surgical stapler having force-based motor control
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10368864B2 (en) 2017-06-20 2019-08-06 Ethicon Llc Systems and methods for controlling displaying motor velocity for a surgical instrument
US10376263B2 (en) 2016-04-01 2019-08-13 Ethicon Llc Anvil modification members for surgical staplers
US10390841B2 (en) 2017-06-20 2019-08-27 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10390833B2 (en) 2008-05-12 2019-08-27 Boston Scientific Scimed, Inc. Tissue anchor for securing tissue layers
US10398440B2 (en) 2002-04-26 2019-09-03 Torax Medical, Inc. Methods and apparatus for treating body tissue sphincters and the like
US10398434B2 (en) 2017-06-29 2019-09-03 Ethicon Llc Closed loop velocity control of closure member for robotic surgical instrument
US10398445B2 (en) 2011-01-11 2019-09-03 Amsel Medical Corporation Method and apparatus for clamping tissue layers and occluding tubular body structures
US10405859B2 (en) 2016-04-15 2019-09-10 Ethicon Llc Surgical instrument with adjustable stop/start control during a firing motion
US10413294B2 (en) 2012-06-28 2019-09-17 Ethicon Llc Shaft assembly arrangements for surgical instruments
US10426481B2 (en) 2014-02-24 2019-10-01 Ethicon Llc Implantable layer assemblies
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US10426471B2 (en) 2016-12-21 2019-10-01 Ethicon Llc Surgical instrument with multiple failure response modes
US10433838B2 (en) 2009-03-18 2019-10-08 Endogastric Solutions, Inc. Methods and devices for forming a tissue fold
US10448948B2 (en) 2016-02-12 2019-10-22 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10448950B2 (en) 2016-12-21 2019-10-22 Ethicon Llc Surgical staplers with independently actuatable closing and firing systems
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US10485543B2 (en) 2016-12-21 2019-11-26 Ethicon Llc Anvil having a knife slot width
US10492783B2 (en) 2016-04-15 2019-12-03 Ethicon, Llc Surgical instrument with improved stop/start control during a firing motion
US10492785B2 (en) 2016-12-21 2019-12-03 Ethicon Llc Shaft assembly comprising a lockout
USD869655S1 (en) 2017-06-28 2019-12-10 Ethicon Llc Surgical fastener cartridge
US10499914B2 (en) 2016-12-21 2019-12-10 Ethicon Llc Staple forming pocket arrangements
US10499890B2 (en) 2006-01-31 2019-12-10 Ethicon Llc Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US10517594B2 (en) 2014-10-29 2019-12-31 Ethicon Llc Cartridge assemblies for surgical staplers
US10517596B2 (en) 2016-12-21 2019-12-31 Ethicon Llc Articulatable surgical instruments with articulation stroke amplification features
US10537325B2 (en) 2016-12-21 2020-01-21 Ethicon Llc Staple forming pocket arrangement to accommodate different types of staples
US10537324B2 (en) 2016-12-21 2020-01-21 Ethicon Llc Stepped staple cartridge with asymmetrical staples
US10542979B2 (en) 2016-06-24 2020-01-28 Ethicon Llc Stamped staples and staple cartridges using the same
US10568652B2 (en) 2006-09-29 2020-02-25 Ethicon Llc Surgical staples having attached drivers of different heights and stapling instruments for deploying the same
US10568625B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Staple cartridges and arrangements of staples and staple cavities therein
US10568626B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaw opening features for increasing a jaw opening distance
US10575868B2 (en) 2013-03-01 2020-03-03 Ethicon Llc Surgical instrument with coupler assembly
US10588633B2 (en) 2017-06-28 2020-03-17 Ethicon Llc Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing
US10588632B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical end effectors and firing members thereof
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
WO2020072259A1 (en) 2018-10-03 2020-04-09 Absolutions Med, Inc. Abdominal closure method and device variations
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US10617418B2 (en) 2015-08-17 2020-04-14 Ethicon Llc Implantable layers for a surgical instrument
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
US10631859B2 (en) 2017-06-27 2020-04-28 Ethicon Llc Articulation systems for surgical instruments
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
US10667809B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Staple cartridge and staple cartridge channel comprising windows defined therein
US10675028B2 (en) 2006-01-31 2020-06-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US10682134B2 (en) 2017-12-21 2020-06-16 Ethicon Llc Continuous use self-propelled stapling instrument
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US10687810B2 (en) 2016-12-21 2020-06-23 Ethicon Llc Stepped staple cartridge with tissue retention and gap setting features
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US10695062B2 (en) 2010-10-01 2020-06-30 Ethicon Llc Surgical instrument including a retractable firing member
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
US10722363B2 (en) 2012-02-29 2020-07-28 Valcare, Inc. Methods, devices, and systems for percutaneously anchoring annuloplasty rings
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
US10729501B2 (en) 2017-09-29 2020-08-04 Ethicon Llc Systems and methods for language selection of a surgical instrument
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
US10751076B2 (en) 2009-12-24 2020-08-25 Ethicon Llc Motor-driven surgical cutting instrument with electric actuator directional control assembly
US10758229B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument comprising improved jaw control
US10758230B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument with primary and safety processors
US10758233B2 (en) 2009-02-05 2020-09-01 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US10765424B2 (en) 2008-02-13 2020-09-08 Ethicon Llc Surgical stapling instrument
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US10779945B2 (en) 2011-06-01 2020-09-22 Valcare, Inc. Percutaneous transcatheter repair of heart valves via trans-apical access
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US10779824B2 (en) 2017-06-28 2020-09-22 Ethicon Llc Surgical instrument comprising an articulation system lockable by a closure system
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
US10792025B2 (en) 2009-06-22 2020-10-06 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10796471B2 (en) 2017-09-29 2020-10-06 Ethicon Llc Systems and methods of displaying a knife position for a surgical instrument
US10806437B2 (en) 2009-06-22 2020-10-20 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10813751B2 (en) 2013-05-22 2020-10-27 Valcare, Inc. Transcatheter prosthetic valve for mitral or tricuspid valve replacement
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US10820895B2 (en) 2011-01-11 2020-11-03 Amsel Medical Corporation Methods and apparatus for fastening and clamping tissue
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US10828028B2 (en) 2016-04-15 2020-11-10 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
US10918391B2 (en) 2011-01-11 2021-02-16 Amsel Medical Corporation Method and apparatus for clamping tissue and occluding tubular body lumens
US10918373B2 (en) 2013-08-31 2021-02-16 Edwards Lifesciences Corporation Devices and methods for locating and implanting tissue anchors at mitral valve commissure
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US10945727B2 (en) 2016-12-21 2021-03-16 Ethicon Llc Staple cartridge with deformable driver retention features
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US10945735B2 (en) 2004-04-12 2021-03-16 Boston Scientific Scimed, Inc. Luminal structure anchoring devices and methods
US10945716B2 (en) 2005-09-01 2021-03-16 Cordis Corporation Patent foramen ovale closure method
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
US10987102B2 (en) 2010-09-30 2021-04-27 Ethicon Llc Tissue thickness compensator comprising a plurality of layers
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US10993715B2 (en) 2016-12-21 2021-05-04 Ethicon Llc Staple cartridge comprising staples with different clamping breadths
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
US11013511B2 (en) 2007-06-22 2021-05-25 Ethicon Llc Surgical stapling instrument with an articulatable end effector
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
US11020109B2 (en) 2013-12-23 2021-06-01 Ethicon Llc Surgical stapling assembly for use with a powered surgical interface
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11051813B2 (en) 2006-01-31 2021-07-06 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11058538B2 (en) 2016-03-10 2021-07-13 Charles Somers Living Trust Synthetic chord for cardiac valve repair applications
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US11071545B2 (en) 2014-09-05 2021-07-27 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US11103349B2 (en) 2016-08-15 2021-08-31 Valcare, Inc. Devices and methods for the treatment of heart valve insufficiencies
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
US11133106B2 (en) 2013-08-23 2021-09-28 Cilag Gmbh International Surgical instrument assembly comprising a retraction assembly
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11179341B2 (en) 2017-05-17 2021-11-23 Massachusetts Institute Of Technology Self-righting articles
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11197671B2 (en) 2012-06-28 2021-12-14 Cilag Gmbh International Stapling assembly comprising a lockout
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US11202633B2 (en) 2014-09-26 2021-12-21 Cilag Gmbh International Surgical stapling buttresses and adjunct materials
US11202903B2 (en) 2018-05-17 2021-12-21 Massachusetts Institute Of Technology Systems for electrical stimulation
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US11213295B2 (en) 2015-09-02 2022-01-04 Cilag Gmbh International Surgical staple configurations with camming surfaces located between portions supporting surgical staples
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11219456B2 (en) 2015-08-26 2022-01-11 Cilag Gmbh International Surgical staple strips for permitting varying staple properties and enabling easy cartridge loading
US11224428B2 (en) 2016-12-21 2022-01-18 Cilag Gmbh International Surgical stapling systems
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11229437B2 (en) 2019-06-28 2022-01-25 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11241230B2 (en) 2012-06-28 2022-02-08 Cilag Gmbh International Clip applier tool for use with a robotic surgical system
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11259799B2 (en) 2014-03-26 2022-03-01 Cilag Gmbh International Interface systems for use with surgical instruments
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US11266409B2 (en) 2014-04-16 2022-03-08 Cilag Gmbh International Fastener cartridge comprising a sled including longitudinally-staggered ramps
US11272927B2 (en) 2008-02-15 2022-03-15 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US11284898B2 (en) 2014-09-18 2022-03-29 Cilag Gmbh International Surgical instrument including a deployable knife
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US11291449B2 (en) 2009-12-24 2022-04-05 Cilag Gmbh International Surgical cutting instrument that analyzes tissue thickness
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US11298230B2 (en) 2012-02-29 2022-04-12 Valcare, Inc. Percutaneous annuloplasty system with anterior-posterior adjustment
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US11317913B2 (en) 2016-12-21 2022-05-03 Cilag Gmbh International Lockout arrangements for surgical end effectors and replaceable tool assemblies
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US11350928B2 (en) 2016-04-18 2022-06-07 Cilag Gmbh International Surgical instrument comprising a tissue thickness lockout and speed control system
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US11382627B2 (en) 2014-04-16 2022-07-12 Cilag Gmbh International Surgical stapling assembly comprising a firing member including a lateral extension
US11382749B2 (en) 2013-03-15 2022-07-12 Valcare, Inc. Systems and methods for delivery of annuloplasty rings
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
US11464513B2 (en) 2012-06-28 2022-10-11 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11478247B2 (en) 2010-07-30 2022-10-25 Cilag Gmbh International Tissue acquisition arrangements and methods for surgical stapling devices
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US11491315B2 (en) 2017-06-20 2022-11-08 Boston Scientific Scimed, Inc. Systems and methods for creating permanent drainage fistula
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
US11523823B2 (en) 2016-02-09 2022-12-13 Cilag Gmbh International Surgical instruments with non-symmetrical articulation arrangements
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
US11534300B2 (en) 2018-12-03 2022-12-27 Valcare, Inc. Stabilizing and adjusting tool for controlling a minimally invasive mitral / tricuspid valve repair system
US11541016B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
US11564682B2 (en) 2007-06-04 2023-01-31 Cilag Gmbh International Surgical stapler device
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
US11571215B2 (en) 2010-09-30 2023-02-07 Cilag Gmbh International Layer of material for a surgical end effector
US11576779B2 (en) 2017-03-17 2023-02-14 Valcare, Inc. Mitral or tricuspid repair systems with multi-directional anchors
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11622763B2 (en) 2013-04-16 2023-04-11 Cilag Gmbh International Stapling assembly comprising a shiftable drive
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11638582B2 (en) 2020-07-28 2023-05-02 Cilag Gmbh International Surgical instruments with torsion spine drive arrangements
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
US11654017B2 (en) 2013-05-24 2023-05-23 Valcare, Inc. Heart and peripheral vascular valve replacement in conjunction with a support ring
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
US11666476B2 (en) * 2004-02-26 2023-06-06 Linguaflex, Inc. Method and device for the treatment of obstructive sleep apnea and snoring
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11678877B2 (en) 2014-12-18 2023-06-20 Cilag Gmbh International Surgical instrument including a flexible support configured to support a flexible firing member
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11684367B2 (en) 2016-12-21 2023-06-27 Cilag Gmbh International Stepped assembly having and end-of-life indicator
US11690619B2 (en) 2016-06-24 2023-07-04 Cilag Gmbh International Staple cartridge comprising staples having different geometries
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11717294B2 (en) 2014-04-16 2023-08-08 Cilag Gmbh International End effector arrangements comprising indicators
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11723662B2 (en) 2021-05-28 2023-08-15 Cilag Gmbh International Stapling instrument comprising an articulation control display
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11766259B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US11766260B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Methods of stapling tissue
WO2023179576A1 (en) * 2022-03-21 2023-09-28 南微医学科技股份有限公司 Anchoring device and anchoring instrument
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11793522B2 (en) 2015-09-30 2023-10-24 Cilag Gmbh International Staple cartridge assembly including a compressible adjunct
US11793628B2 (en) 2019-07-15 2023-10-24 Valcare, Inc. Transcatheter bio-prosthesis member and support structure
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11826132B2 (en) 2015-03-06 2023-11-28 Cilag Gmbh International Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11826048B2 (en) 2017-06-28 2023-11-28 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11849952B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11877920B2 (en) 2019-04-10 2024-01-23 Absolutions Med, Inc. Abdominal closure method and device variations for closing ventral hernias and reducing recurrence
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11883026B2 (en) 2014-04-16 2024-01-30 Cilag Gmbh International Fastener cartridge assemblies and staple retainer cover arrangements
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11890012B2 (en) 2004-07-28 2024-02-06 Cilag Gmbh International Staple cartridge comprising cartridge body and attached support
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11896229B2 (en) 2020-09-01 2024-02-13 Boston Scientific Scimed, Inc. Grappling systems and methods for lumen apposition or wound defects
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11918209B2 (en) 2017-11-10 2024-03-05 Cilag Gmbh International Torque optimization for surgical instruments

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7744613B2 (en) 1999-06-25 2010-06-29 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7618426B2 (en) 2002-12-11 2009-11-17 Usgi Medical, Inc. Apparatus and methods for forming gastrointestinal tissue approximations
US7033373B2 (en) 2000-11-03 2006-04-25 Satiety, Inc. Method and device for use in minimally invasive placement of space-occupying intragastric devices
US6558400B2 (en) 2001-05-30 2003-05-06 Satiety, Inc. Obesity treatment tools and methods
US6746460B2 (en) 2002-08-07 2004-06-08 Satiety, Inc. Intra-gastric fastening devices
US20040044364A1 (en) * 2002-08-29 2004-03-04 Devries Robert Tissue fasteners and related deployment systems and methods
US7214233B2 (en) 2002-08-30 2007-05-08 Satiety, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US7033384B2 (en) 2002-08-30 2006-04-25 Satiety, Inc. Stented anchoring of gastric space-occupying devices
US8454628B2 (en) 2002-09-20 2013-06-04 Syntheon, Llc Surgical fastener aligning instrument particularly for transoral treatment of gastroesophageal reflux disease
US7033378B2 (en) 2002-09-20 2006-04-25 Id, Llc Surgical fastener, particularly for the endoluminal treatment of gastroesophageal reflux disease (GERD)
US7678122B2 (en) 2002-09-20 2010-03-16 Id, Llc Method of performing a treatment for gastroesophagheal reflux disease (GERD)
US6966919B2 (en) 2002-09-20 2005-11-22 Id, Llc Instrument for applying a surgical fastener particularly for the transoral treatment of gastroesophageal reflux disease (GERD)
US7220237B2 (en) 2002-10-23 2007-05-22 Satiety, Inc. Method and device for use in endoscopic organ procedures
US7942898B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Delivery systems and methods for gastric reduction
US7942884B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Methods for reduction of a gastric lumen
US7175638B2 (en) 2003-04-16 2007-02-13 Satiety, Inc. Method and devices for modifying the function of a body organ
US8216252B2 (en) 2004-05-07 2012-07-10 Usgi Medical, Inc. Tissue manipulation and securement system
US7097650B2 (en) 2003-10-14 2006-08-29 Satiety, Inc. System for tissue approximation and fixation
US7914543B2 (en) 2003-10-14 2011-03-29 Satiety, Inc. Single fold device for tissue fixation
US7361180B2 (en) 2004-05-07 2008-04-22 Usgi Medical, Inc. Apparatus for manipulating and securing tissue
US20050177176A1 (en) 2004-02-05 2005-08-11 Craig Gerbi Single-fold system for tissue approximation and fixation
EP1713402B1 (en) 2004-02-13 2018-07-04 Ethicon Endo-Surgery, Inc. Device for reducing stomach volume
US7708684B2 (en) 2004-02-27 2010-05-04 Satiety, Inc. Methods and devices for reducing hollow organ volume
US9028511B2 (en) 2004-03-09 2015-05-12 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US7703459B2 (en) 2004-03-09 2010-04-27 Usgi Medical, Inc. Apparatus and methods for mapping out endoluminal gastrointestinal surgery
US8252009B2 (en) 2004-03-09 2012-08-28 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US8449560B2 (en) 2004-03-09 2013-05-28 Satiety, Inc. Devices and methods for placement of partitions within a hollow body organ
CA2561193A1 (en) 2004-03-26 2005-10-20 Satiety, Inc. Systems and methods for treating obesity
US20050251208A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Linear anchors for anchoring to tissue
US7736374B2 (en) 2004-05-07 2010-06-15 Usgi Medical, Inc. Tissue manipulation and securement system
US8057511B2 (en) 2004-05-07 2011-11-15 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US7918869B2 (en) 2004-05-07 2011-04-05 Usgi Medical, Inc. Methods and apparatus for performing endoluminal gastroplasty
US7736379B2 (en) 2004-06-09 2010-06-15 Usgi Medical, Inc. Compressible tissue anchor assemblies
US7695493B2 (en) 2004-06-09 2010-04-13 Usgi Medical, Inc. System for optimizing anchoring force
US8206417B2 (en) 2004-06-09 2012-06-26 Usgi Medical Inc. Apparatus and methods for optimizing anchoring force
US7931661B2 (en) 2004-06-14 2011-04-26 Usgi Medical, Inc. Apparatus and methods for performing transluminal gastrointestinal procedures
US20060106288A1 (en) 2004-11-17 2006-05-18 Roth Alex T Remote tissue retraction device
US7645286B2 (en) 2005-05-20 2010-01-12 Neotract, Inc. Devices, systems and methods for retracting, lifting, compressing, supporting or repositioning tissues or anatomical structures
US7896891B2 (en) 2005-05-20 2011-03-01 Neotract, Inc. Apparatus and method for manipulating or retracting tissue and anatomical structure
US9549739B2 (en) 2005-05-20 2017-01-24 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US8425535B2 (en) 2005-05-20 2013-04-23 Neotract, Inc. Multi-actuating trigger anchor delivery system
US8628542B2 (en) 2005-05-20 2014-01-14 Neotract, Inc. Median lobe destruction apparatus and method
US8945152B2 (en) 2005-05-20 2015-02-03 Neotract, Inc. Multi-actuating trigger anchor delivery system
US9364212B2 (en) 2005-05-20 2016-06-14 Neotract, Inc. Suture anchoring devices and methods for use
US8529584B2 (en) 2005-05-20 2013-09-10 Neotract, Inc. Median lobe band implant apparatus and method
US8333776B2 (en) 2005-05-20 2012-12-18 Neotract, Inc. Anchor delivery system
US9149266B2 (en) 2005-05-20 2015-10-06 Neotract, Inc. Deforming anchor device
US10195014B2 (en) 2005-05-20 2019-02-05 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US10925587B2 (en) 2005-05-20 2021-02-23 Neotract, Inc. Anchor delivery system
US7758594B2 (en) 2005-05-20 2010-07-20 Neotract, Inc. Devices, systems and methods for treating benign prostatic hyperplasia and other conditions
US9504461B2 (en) 2005-05-20 2016-11-29 Neotract, Inc. Anchor delivery system
US8668705B2 (en) 2005-05-20 2014-03-11 Neotract, Inc. Latching anchor device
US8603106B2 (en) 2005-05-20 2013-12-10 Neotract, Inc. Integrated handle assembly for anchor delivery system
US8834492B2 (en) 2005-05-20 2014-09-16 Neotract, Inc. Continuous indentation lateral lobe apparatus and method
US8394113B2 (en) 2005-05-20 2013-03-12 Neotract, Inc. Coiled anchor device
US8870916B2 (en) 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US8348972B2 (en) * 2007-07-11 2013-01-08 Covidien Lp Surgical staple with augmented compression area
US8343029B2 (en) * 2007-10-24 2013-01-01 Circulite, Inc. Transseptal cannula, tip, delivery system, and method
US8821366B2 (en) 2007-10-24 2014-09-02 Circulite, Inc. Transseptal cannula, tip, delivery system, and method
WO2010014825A1 (en) 2008-07-30 2010-02-04 Neotract, Inc. Slotted anchor device
US9839415B2 (en) * 2009-01-30 2017-12-12 St. Jude Medical, Llc Apex closure device
EP2391286B1 (en) 2009-01-30 2017-07-19 St. Jude Medical, Inc. Transapical mini-introducer homeostasis valve and punch
US8961596B2 (en) 2010-01-22 2015-02-24 4Tech Inc. Method and apparatus for tricuspid valve repair using tension
US8475525B2 (en) * 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
US10058323B2 (en) 2010-01-22 2018-08-28 4 Tech Inc. Tricuspid valve repair using tension
US9307980B2 (en) 2010-01-22 2016-04-12 4Tech Inc. Tricuspid valve repair using tension
US9241702B2 (en) 2010-01-22 2016-01-26 4Tech Inc. Method and apparatus for tricuspid valve repair using tension
KR20140015413A (en) 2011-03-08 2014-02-06 더블유.엘. 고어 앤드 어소시에이트스, 인코포레이티드 Medical device for use with a stoma
US9161749B2 (en) 2011-04-14 2015-10-20 Neotract, Inc. Method and apparatus for treating sexual dysfunction
US10292801B2 (en) 2012-03-29 2019-05-21 Neotract, Inc. System for delivering anchors for treating incontinence
US8961594B2 (en) 2012-05-31 2015-02-24 4Tech Inc. Heart valve repair system
US10130353B2 (en) 2012-06-29 2018-11-20 Neotract, Inc. Flexible system for delivering an anchor
WO2014108903A1 (en) 2013-01-09 2014-07-17 4Tech Inc. Soft tissue anchors
EP2958527B1 (en) 2013-02-21 2020-07-22 Boston Scientific Scimed, Inc. Devices for forming an anastomosis
JP6329570B2 (en) 2013-03-14 2018-05-23 4テック インコーポレイテッド Stent with tether interface
US10052095B2 (en) 2013-10-30 2018-08-21 4Tech Inc. Multiple anchoring-point tension system
US10022114B2 (en) 2013-10-30 2018-07-17 4Tech Inc. Percutaneous tether locking
WO2015063580A2 (en) 2013-10-30 2015-05-07 4Tech Inc. Multiple anchoring-point tension system
US9936950B2 (en) * 2013-11-08 2018-04-10 Ethicon Llc Hybrid adjunct materials for use in surgical stapling
US10363040B2 (en) 2014-05-02 2019-07-30 W. L. Gore & Associates, Inc. Anastomosis devices
US11712230B2 (en) 2014-05-02 2023-08-01 W. L. Gore & Associates, Inc. Occluder and anastomosis devices
US11439396B2 (en) 2014-05-02 2022-09-13 W. L. Gore & Associates, Inc. Occluder and anastomosis devices
JP6559161B2 (en) 2014-06-19 2019-08-14 4テック インコーポレイテッド Tightening heart tissue
EP3284412A1 (en) 2014-12-02 2018-02-21 4Tech Inc. Off-center tissue anchors
US10595875B2 (en) 2014-12-31 2020-03-24 Endostream Medical Ltd. Device for restricting blood flow to aneurysms
CN109688973B (en) 2016-06-21 2021-05-28 内流医疗有限公司 Medical device for treating vascular malformation
CN110248623B (en) * 2016-11-29 2021-12-21 埃斯卡拉医疗公司 Anchor delivery systems and methods
US11724075B2 (en) 2017-04-18 2023-08-15 W. L. Gore & Associates, Inc. Deployment constraining sheath that enables staged deployment by device section
US10806579B2 (en) 2017-10-20 2020-10-20 Boston Scientific Scimed, Inc. Heart valve repair implant for treating tricuspid regurgitation
US11376127B2 (en) * 2017-12-20 2022-07-05 W. L. Gore & Associates, Inc. Artificial chordae tendineae repair devices and delivery thereof
JP7150871B2 (en) 2017-12-23 2022-10-11 テレフレックス ライフ サイエンシズ リミテッド Expandable tissue engagement device and method
US11812970B2 (en) 2019-01-17 2023-11-14 Endostream Medical Ltd. Vascular-malformation implant system
EP3943015A4 (en) * 2019-03-22 2022-12-07 Tohoku University Anchor instrument
US11840032B2 (en) 2020-07-06 2023-12-12 Pratt & Whitney Canada Corp. Method of repairing a combustor liner of a gas turbine engine
DK3989844T3 (en) 2020-08-03 2023-10-30 Teleflex Life Sciences Ltd Handle and cartridge system for medical inventions
US11857417B2 (en) 2020-08-16 2024-01-02 Trilio Medical Ltd. Leaflet support

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091205A (en) * 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5733294A (en) * 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US5976127A (en) * 1998-01-14 1999-11-02 Lax; Ronald Soft tissue fixation devices
US6113609A (en) * 1998-05-26 2000-09-05 Scimed Life Systems, Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
US6231561B1 (en) * 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US20010010005A1 (en) * 2000-01-24 2001-07-26 Kammerer Gene W. Meniscal repair device
US6326025B1 (en) * 1998-12-30 2001-12-04 Depuy Orthopaedics, Inc Tissue reactive adhesive compositions
US6425900B1 (en) * 2000-10-19 2002-07-30 Ethicon Endo-Surgery Method for attaching hernia mesh
US20020156344A1 (en) * 2001-04-04 2002-10-24 Pasricha Pankaj Jay Endoscopic instruments
US6491714B1 (en) * 1996-05-03 2002-12-10 William F. Bennett Surgical tissue repair and attachment apparatus and method
US20030220660A1 (en) * 2002-04-24 2003-11-27 Kortenbach Juergen A. Tissue fastening devices and processes that promote tissue adhesion
US6736828B1 (en) * 2000-09-29 2004-05-18 Scimed Life Systems, Inc. Method for performing endoluminal fundoplication and apparatus for use in the method
US7160314B2 (en) * 2000-11-24 2007-01-09 Sofradim Production Fastener for fixing a prosthesis, and device for delivering this fastener

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006747A (en) 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4275490A (en) * 1978-11-27 1981-06-30 Bivins Charles F Method and apparatus for securing calvarium skull section to basal skull section
US5217484A (en) * 1991-06-07 1993-06-08 Marks Michael P Retractable-wire catheter device and method
US5290310A (en) 1991-10-30 1994-03-01 Howmedica, Inc. Hemostatic implant introducer
WO1996001591A1 (en) 1994-07-08 1996-01-25 Microvena Corporation Method of forming medical devices; intravascular occlusion devices
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5702421A (en) * 1995-01-11 1997-12-30 Schneidt; Bernhard Closure device for closing a vascular opening, such as patent ductus arteriosus
JP3134287B2 (en) * 1997-01-30 2001-02-13 株式会社ニッショー Catheter assembly for endocardial suture surgery
DE19731834A1 (en) * 1997-07-24 1999-06-17 Ernst Peter Prof Dr M Strecker Implantation device
US6174322B1 (en) * 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6099552A (en) 1997-11-12 2000-08-08 Boston Scientific Corporation Gastrointestinal copression clips
US6626919B1 (en) * 1997-12-29 2003-09-30 Lee L. Swanstrom Method and apparatus for attaching or locking an implant to an anatomic vessel or hollow organ wall
US6648903B1 (en) * 1998-09-08 2003-11-18 Pierson, Iii Raymond H. Medical tensioning system
US6494888B1 (en) * 1999-06-22 2002-12-17 Ndo Surgical, Inc. Tissue reconfiguration
JP2001052292A (en) 1999-08-11 2001-02-23 Nippon Telegr & Teleph Corp <Ntt> Alarm device for obstacle at high place
US6387104B1 (en) * 1999-11-12 2002-05-14 Scimed Life Systems, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US6387114B2 (en) * 2000-04-28 2002-05-14 Scimed Life Systems, Inc. Gastrointestinal compression clips
DE60031175D1 (en) * 2000-06-12 2006-11-16 Jeffrey E Yeung REPAIR OF INTERMEDIATE WHEELS
US6440152B1 (en) * 2000-07-28 2002-08-27 Microvena Corporation Defect occluder release assembly and method
AU2001292563A1 (en) * 2000-09-01 2002-03-13 Advanced Vascular Technologies, Llc Multi-fastener surgical apparatus and method
US6616684B1 (en) * 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
US6716234B2 (en) * 2001-09-13 2004-04-06 Arthrex, Inc. High strength suture material
CA2467702C (en) * 2002-03-15 2009-01-13 Nmt Medical, Inc. Coupling system useful in placement of implants
US20040044364A1 (en) * 2002-08-29 2004-03-04 Devries Robert Tissue fasteners and related deployment systems and methods

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091205A (en) * 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5733294A (en) * 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US6491714B1 (en) * 1996-05-03 2002-12-10 William F. Bennett Surgical tissue repair and attachment apparatus and method
US5976127A (en) * 1998-01-14 1999-11-02 Lax; Ronald Soft tissue fixation devices
US6113609A (en) * 1998-05-26 2000-09-05 Scimed Life Systems, Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
US6326025B1 (en) * 1998-12-30 2001-12-04 Depuy Orthopaedics, Inc Tissue reactive adhesive compositions
US6231561B1 (en) * 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US20010010005A1 (en) * 2000-01-24 2001-07-26 Kammerer Gene W. Meniscal repair device
US6736828B1 (en) * 2000-09-29 2004-05-18 Scimed Life Systems, Inc. Method for performing endoluminal fundoplication and apparatus for use in the method
US6425900B1 (en) * 2000-10-19 2002-07-30 Ethicon Endo-Surgery Method for attaching hernia mesh
US7160314B2 (en) * 2000-11-24 2007-01-09 Sofradim Production Fastener for fixing a prosthesis, and device for delivering this fastener
US20020156344A1 (en) * 2001-04-04 2002-10-24 Pasricha Pankaj Jay Endoscopic instruments
US20030220660A1 (en) * 2002-04-24 2003-11-27 Kortenbach Juergen A. Tissue fastening devices and processes that promote tissue adhesion

Cited By (1813)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050149170A1 (en) * 1998-08-25 2005-07-07 Tassel Robert A.V. Implantable device for promoting repair of a body lumen
US20090198254A1 (en) * 1999-06-22 2009-08-06 Ethicon Endo-Surgery, Inc. Methods and Devices for Tissue Reconfiguration
US20060025789A1 (en) * 1999-06-22 2006-02-02 Ndo Surgical, Inc., A Massachusetts Corporation Methods and devices for tissue reconfiguration
US7713277B2 (en) 1999-06-22 2010-05-11 Ethicon Endo-Surgery, Inc. Tissue reconfiguration
US20040133238A1 (en) * 1999-06-22 2004-07-08 Cerier Jeffrey C. Tissue fixation devices and methods of fixing tissue
US20040193193A1 (en) * 1999-06-22 2004-09-30 Ndo Surgical, Inc., A Massachusetts Corporation Tissue reconfiguration
US20040194790A1 (en) * 1999-06-22 2004-10-07 Ndo Surgical, Inc. Tissue reconfiguration
US7722633B2 (en) 1999-06-22 2010-05-25 Ethicon Endo-Surgery, Inc. Tissue reconfiguration
US7736373B2 (en) 1999-06-22 2010-06-15 Ndo Surical, Inc. Methods and devices for tissue reconfiguration
US7896893B2 (en) 1999-06-22 2011-03-01 Ethicon Endo-Surgery, Inc. Methods and devices for tissue reconfiguration
US20040010245A1 (en) * 1999-06-22 2004-01-15 Cerier Jeffrey C. Method and devices for tissue reconfiguration
US20050033328A1 (en) * 1999-06-22 2005-02-10 Ndo Surgical, Inc., A Massachusetts Corporation Methods and devices for tissue reconfiguration
US8287554B2 (en) 1999-06-22 2012-10-16 Ethicon Endo-Surgery, Inc. Method and devices for tissue reconfiguration
US7776057B2 (en) 1999-06-22 2010-08-17 Ethicon Endo-Surgery, Inc. Methods and devices for tissue reconfiguration
US8277468B2 (en) 1999-06-22 2012-10-02 Ethicon Endo-Surgery, Inc. Tissue reconfiguration
US7846180B2 (en) 1999-06-22 2010-12-07 Ethicon Endo-Surgery, Inc. Tissue fixation devices and methods of fixing tissue
US8057494B2 (en) 1999-06-22 2011-11-15 Ethicon Endo-Surgery, Inc. Methods and devices for tissue reconfiguration
US7857823B2 (en) 1999-06-22 2010-12-28 Ethicon Endo-Surgery, Inc. Tissue reconfiguration
US20020161382A1 (en) * 2001-03-29 2002-10-31 Neisz Johann J. Implant inserted without bone anchors
US9358112B2 (en) 2001-04-24 2016-06-07 Mitralign, Inc. Method and apparatus for catheter-based annuloplasty using local plications
US9968353B2 (en) 2001-06-04 2018-05-15 Medtronic Vascular, Inc. Catheter based fastener implantation apparatus and methods
US9138340B2 (en) 2001-08-27 2015-09-22 Boston Scientific Scimed, Inc. Gastro-esophageal implants
US9844453B2 (en) 2001-08-27 2017-12-19 Boston Scientific Scimed, Inc. Positioning tools and methods for implanting medical devices
US7892292B2 (en) 2001-08-27 2011-02-22 Synecor, Llc Positioning tools and methods for implanting medical devices
US8568488B2 (en) 2001-08-27 2013-10-29 Boston Scientific Scimed, Inc. Satiation devices and methods
US9358144B2 (en) 2001-08-27 2016-06-07 Boston Scientific Scimed, Inc. Gastrointestinal implants
US20110153030A1 (en) * 2001-08-27 2011-06-23 Synecor, Llc Positioning tools and methods for implanting medical devices
US9180036B2 (en) 2001-08-27 2015-11-10 Boston Scientific Scimed, Inc. Methods for implanting medical devices
US9872786B2 (en) 2001-08-27 2018-01-23 Boston Scientific Scimed, Inc. Gastro-esophageal implants
US9254214B2 (en) 2001-08-27 2016-02-09 Boston Scientific Scimed, Inc. Satiation devices and methods
US20060287734A1 (en) * 2001-08-27 2006-12-21 Synecor, Llc Positioning tools and methods for implanting medical devices
US20100016988A1 (en) * 2001-08-27 2010-01-21 Stack Richard S Satiation devices and methods
US9107727B2 (en) 2001-08-27 2015-08-18 Boston Scientific Scimed, Inc. Satiation devices and methods
US20100298631A1 (en) * 2001-08-27 2010-11-25 Stack Richard S Satiation devices and methods
US10080677B2 (en) 2001-08-27 2018-09-25 Boston Scientific Scimed, Inc. Satiation devices and methods
US8784354B2 (en) 2001-08-27 2014-07-22 Boston Scientific Scimed, Inc. Positioning tools and methods for implanting medical devices
US8845753B2 (en) 2001-08-27 2014-09-30 Boston Scientific Scimed, Inc. Satiation devices and methods
US8992457B2 (en) 2001-08-27 2015-03-31 Boston Scientific Scimed, Inc. Gastrointestinal implants
US9788984B2 (en) 2001-08-27 2017-10-17 Boston Scientific Scimed, Inc. Satiation devices and methods
US20060100640A1 (en) * 2001-11-28 2006-05-11 Aptus Endosystems, Inc. Devices, system, and methods for guiding an operative tool into an interior body region
US9808250B2 (en) 2001-11-28 2017-11-07 Medtronic Vascular, Inc. Systems and methods for attaching a prosthesis within a body lumen or hollow organ
US9023065B2 (en) 2001-11-28 2015-05-05 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
US10299791B2 (en) 2001-11-28 2019-05-28 Medtronic Vascular, Inc. Endovascular aneurysm repair system
US20110238088A1 (en) * 2001-11-28 2011-09-29 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
US10098770B2 (en) 2001-11-28 2018-10-16 Medtronic Vascular, Inc. Endovascular aneurysm devices, systems, and methods
US9320589B2 (en) 2001-11-28 2016-04-26 Medtronic Vascular, Inc. Endovascular aneurysm repair system
US9320503B2 (en) 2001-11-28 2016-04-26 Medtronic Vascular, Inc. Devices, system, and methods for guiding an operative tool into an interior body region
US20110087320A1 (en) * 2001-11-28 2011-04-14 Aptus Endosystems, Inc. Devices, Systems, and Methods for Prosthesis Delivery and Implantation, Including a Prosthesis Assembly
US10595867B2 (en) 2001-11-28 2020-03-24 Medtronic Vascular, Inc. Systems and methods for attaching a prosthesis within a body lumen or hollow organ
US10194905B2 (en) 2001-11-28 2019-02-05 Medtronic Vascular, Inc. Devices, systems, and methods for endovascular staple and/or prosthesis delivery and implantation
US10357230B2 (en) 2001-11-28 2019-07-23 Medtronic Vascular, Inc. Devices, system, and methods for guiding an operative tool into an interior body region
US20090099650A1 (en) * 2001-11-28 2009-04-16 Lee Bolduc Devices, systems, and methods for endovascular staple and/or prosthesis delivery and implantation
US20100100109A1 (en) * 2002-04-08 2010-04-22 Stack Richard S Method and apparatus for modifying the exit orifice of a satiation pouch
US8337566B2 (en) 2002-04-08 2012-12-25 Barosense, Inc. Method and apparatus for modifying the exit orifice of a satiation pouch
US10398440B2 (en) 2002-04-26 2019-09-03 Torax Medical, Inc. Methods and apparatus for treating body tissue sphincters and the like
US20040243223A1 (en) * 2002-05-17 2004-12-02 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20050085829A1 (en) * 2002-05-17 2005-04-21 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20070162057A1 (en) * 2002-05-17 2007-07-12 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, stystem and method
US20070162058A1 (en) * 2002-05-17 2007-07-12 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20070167961A1 (en) * 2002-05-17 2007-07-19 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US8702734B2 (en) 2002-05-17 2014-04-22 Endogastric Solutions, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US7942887B2 (en) 2002-05-17 2011-05-17 Endogastric Solutions, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20030216754A1 (en) * 2002-05-17 2003-11-20 Scout Medical Technologies, Llc Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20050154405A1 (en) * 2002-05-17 2005-07-14 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20110213390A1 (en) * 2002-05-17 2011-09-01 Kraemer Stefan J M Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20100106168A1 (en) * 2002-08-01 2010-04-29 Selis James E Biopsy devices and methods
US8758369B2 (en) 2002-08-01 2014-06-24 James E. Selis Biopsy devices and methods
US8414602B2 (en) 2002-08-01 2013-04-09 James E. Selis Biopsy devices and methods
US8728104B2 (en) 2002-08-29 2014-05-20 Boston Scientific Scimed, Inc. Devices and methods for fastening tissue layers
US9675352B2 (en) 2002-08-29 2017-06-13 Boston Scientific Scimed, Inc. Devices and methods for fastening tissue layers
US20110124963A1 (en) * 2002-08-29 2011-05-26 Boston Scientific Scimed, Inc. (formerly, Scimed Life Systems, Inc.) Devices and methods for fastening tissue layers
US10028833B2 (en) 2002-10-21 2018-07-24 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
US8460371B2 (en) 2002-10-21 2013-06-11 Mitralign, Inc. Method and apparatus for performing catheter-based annuloplasty using local plications
US8979923B2 (en) 2002-10-21 2015-03-17 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
US7794447B2 (en) 2002-11-01 2010-09-14 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20050096750A1 (en) * 2002-11-01 2005-05-05 Jonathan Kagan Apparatus and methods for treatment of morbid obesity
US20060293742A1 (en) * 2002-11-01 2006-12-28 Mitchell Dann Cuff and sleeve system for gastrointestinal bypass
US20070010866A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Attachment cuff for gastrointestinal implant
US8012135B2 (en) 2002-11-01 2011-09-06 Valentx, Inc. Attachment cuff for gastrointestinal implant
US8012140B1 (en) 2002-11-01 2011-09-06 Valentx, Inc. Methods of transmural attachment in the gastrointestinal system
US20070010865A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Everting gastrointestinal sleeve
US20070010864A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Gastrointestinal implant system
US20040092892A1 (en) * 2002-11-01 2004-05-13 Jonathan Kagan Apparatus and methods for treatment of morbid obesity
US20060020247A1 (en) * 2002-11-01 2006-01-26 Jonathan Kagan Devices and methods for attaching an endolumenal gastrointestinal implant
US8070743B2 (en) 2002-11-01 2011-12-06 Valentx, Inc. Devices and methods for attaching an endolumenal gastrointestinal implant
US7892214B2 (en) 2002-11-01 2011-02-22 Valentx, Inc. Attachment system for transmural attachment at the gastroesophageal junction
US20070010794A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Devices and methods for endolumenal gastrointestinal bypass
US8968270B2 (en) 2002-11-01 2015-03-03 Valentx, Inc. Methods of replacing a gastrointestinal bypass sleeve for therapy adjustment
US10350101B2 (en) 2002-11-01 2019-07-16 Valentx, Inc. Devices and methods for endolumenal gastrointestinal bypass
US20050049718A1 (en) * 2002-11-01 2005-03-03 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20050240279A1 (en) * 2002-11-01 2005-10-27 Jonathan Kagan Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20060206064A1 (en) * 2002-11-01 2006-09-14 Jonathan Kagan Methods of adjusting therapy in a patient having an endolumenal bypass to treat obesity
US20070198074A1 (en) * 2002-11-01 2007-08-23 Mitchell Dann Devices and methods for endolumenal gastrointestinal bypass
US20060206063A1 (en) * 2002-11-01 2006-09-14 Jonathan Kagan Attachment system for transmural attachment at the gastroesophageal junction
US7846138B2 (en) 2002-11-01 2010-12-07 Valentx, Inc. Cuff and sleeve system for gastrointestinal bypass
US20090149871A9 (en) * 2002-11-01 2009-06-11 Jonathan Kagan Devices and methods for treating morbid obesity
US9839546B2 (en) 2002-11-01 2017-12-12 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US20050177181A1 (en) * 2002-11-01 2005-08-11 Jonathan Kagan Devices and methods for treating morbid obesity
US7837669B2 (en) 2002-11-01 2010-11-23 Valentx, Inc. Devices and methods for endolumenal gastrointestinal bypass
US7220284B2 (en) 2002-11-01 2007-05-22 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US9060844B2 (en) 2002-11-01 2015-06-23 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US8182459B2 (en) 2002-11-01 2012-05-22 Valentx, Inc. Devices and methods for endolumenal gastrointestinal bypass
US9561127B2 (en) 2002-11-01 2017-02-07 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US6960233B1 (en) * 2002-12-10 2005-11-01 Torax Medical, Inc. Methods and apparatus for improving the function of biological passages
US8029455B2 (en) 2003-01-16 2011-10-04 Barosense, Inc. Satiation pouches and methods of use
US10736627B2 (en) 2003-05-09 2020-08-11 Covidien Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
US8636191B2 (en) 2003-05-09 2014-01-28 Covidien Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
US20090270887A1 (en) * 2003-05-09 2009-10-29 Tyco Healthcare Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
US10092289B2 (en) 2003-05-09 2018-10-09 Covidien Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
US9301762B2 (en) 2003-05-09 2016-04-05 Covidien Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
US9060770B2 (en) 2003-05-20 2015-06-23 Ethicon Endo-Surgery, Inc. Robotically-driven surgical instrument with E-beam driver
US8783541B2 (en) 2003-05-20 2014-07-22 Frederick E. Shelton, IV Robotically-controlled surgical end effector system
US20070065244A1 (en) * 2003-06-05 2007-03-22 Kabushiki Kaisha Miyanaga Core cutter
US20100145382A1 (en) * 2003-07-14 2010-06-10 Nmt Medical, Inc. Tubular patent foramen ovale (pfo) closure device with catch system
US20070010851A1 (en) * 2003-07-14 2007-01-11 Chanduszko Andrzej J Tubular patent foramen ovale (PFO) closure device with catch system
US9149263B2 (en) 2003-07-14 2015-10-06 W. L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US11375988B2 (en) 2003-07-14 2022-07-05 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US20070244518A1 (en) * 2003-07-14 2007-10-18 Nmt Medical, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US8480706B2 (en) * 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US20130296925A1 (en) * 2003-07-14 2013-11-07 W.L. Gore & Associates, Inc. Tubular Patent Foramen Ovale (PFO) Closure Device with Catch System
US9326759B2 (en) * 2003-07-14 2016-05-03 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US8206456B2 (en) 2003-10-10 2012-06-26 Barosense, Inc. Restrictive and/or obstructive implant system for inducing weight loss
US9248038B2 (en) 2003-10-10 2016-02-02 Boston Scientific Scimed, Inc. Methods for retaining a gastro-esophageal implant
US8784500B2 (en) 2003-10-10 2014-07-22 Boston Scientific Scimed, Inc. Devices and methods for retaining a gastro-esophageal implant
US9445791B2 (en) 2003-10-10 2016-09-20 Boston Scientific Scimed, Inc. Systems and methods related to gastro-esophageal implants
US20100241146A1 (en) * 2003-10-10 2010-09-23 Stack Richard S Devices and methods for retaining a gastro-esophageal implant
US10285836B2 (en) 2003-10-10 2019-05-14 Boston Scientific Scimed, Inc. Systems and methods related to gastro-esophageal implants
US9180035B2 (en) 2003-10-10 2015-11-10 Boston Scientific Scimed, Inc. Devices and methods for retaining a gastro-esophageal implant
US20070276432A1 (en) * 2003-10-10 2007-11-29 Stack Richard S Devices and Methods for Retaining a Gastro-Esophageal Implant
US8142493B2 (en) 2003-12-23 2012-03-27 Mitralign, Inc. Method of heart valve repair
US8864822B2 (en) 2003-12-23 2014-10-21 Mitralign, Inc. Devices and methods for introducing elements into tissue
US20080275503A1 (en) * 2003-12-23 2008-11-06 Mitralign, Inc. Method of heart valve repair
US20060149316A1 (en) * 2003-12-31 2006-07-06 Boston Scientific Scimed, Inc. Devices and methods for tissue invagination
US9700308B2 (en) 2004-02-20 2017-07-11 Endogastric Solutions, Inc. Tissue fixation devices and assemblies for deploying the same
US10064615B2 (en) 2004-02-20 2018-09-04 Endogastric Solutions, Inc. Tissue fixation devices and a transoral endoscopic gastroesophageal flap valve restoration device and assembly using same
US20050187565A1 (en) * 2004-02-20 2005-08-25 Baker Steve G. Tissue fixation devices and a transoral endoscopic gastroesophageal flap valve restoration device and assembly using same
US10357245B2 (en) 2004-02-20 2019-07-23 Endogastric Solutions, Inc. Tissue fixation devices and assemblies for deploying the same
US7632287B2 (en) 2004-02-20 2009-12-15 Endogastric Solutions, Inc. Tissue fixation devices and assemblies for deploying the same
US11666476B2 (en) * 2004-02-26 2023-06-06 Linguaflex, Inc. Method and device for the treatment of obstructive sleep apnea and snoring
US7066944B2 (en) * 2004-03-11 2006-06-27 Laufer Michael D Surgical fastening system
WO2005086885A3 (en) * 2004-03-11 2005-12-01 Michael D Laufer Surgical fastening system
WO2005086885A2 (en) * 2004-03-11 2005-09-22 Laufer Michael D Surgical fastening system
US20050203552A1 (en) * 2004-03-11 2005-09-15 Laufer Michael D. Surgical fastening system
US20050203550A1 (en) * 2004-03-11 2005-09-15 Laufer Michael D. Surgical fastener
EP1734872A4 (en) * 2004-03-24 2014-04-30 Aptus Endosystems Inc Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
WO2005102181A1 (en) 2004-03-24 2005-11-03 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
EP1734872A1 (en) * 2004-03-24 2006-12-27 Aptus endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
US20100131006A1 (en) * 2004-04-09 2010-05-27 Nmt Medical, Inc. Split ends closure device
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US8828049B2 (en) 2004-04-09 2014-09-09 W.L. Gore & Associates, Inc. Split ends closure device and methods of use
US11134949B2 (en) 2004-04-12 2021-10-05 Boston Scientific Scimed, Inc. Luminal structure anchoring devices and methods
US10945735B2 (en) 2004-04-12 2021-03-16 Boston Scientific Scimed, Inc. Luminal structure anchoring devices and methods
US11857160B2 (en) 2004-04-12 2024-01-02 Boston Scientific Scimed, Inc. Luminal structure anchoring devices and methods
US8241202B2 (en) 2004-04-26 2012-08-14 Barosense, Inc. Restrictive and/or obstructive implant for inducing weight loss
US10098773B2 (en) 2004-04-26 2018-10-16 Boston Scientific Scimed, Inc. Restrictive and/or obstructive implant for inducing weight loss
US20090054913A1 (en) * 2004-05-07 2009-02-26 Hubertus Feussner Blind rivet for adapting biological tissue and device for setting the same, in particular through the instrument channel of an endoscope
US8926634B2 (en) 2004-05-07 2015-01-06 Usgi Medical, Inc. Apparatus and methods for manipulating and securing tissue
US20050251176A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. System for treating gastroesophageal reflux disease
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US20060015125A1 (en) * 2004-05-07 2006-01-19 Paul Swain Devices and methods for gastric surgery
WO2005107608A3 (en) * 2004-05-07 2006-05-26 Hubertus Feussner Blind rivet for adapting biological tissue and device for setting the same, in particular through the instrument channel of an endoscope
WO2005107608A2 (en) 2004-05-07 2005-11-17 Hubertus Feussner Blind rivet for adapting biological tissue and device for setting the same, in particular through the instrument channel of an endoscope
US20060135971A1 (en) * 2004-05-07 2006-06-22 Usgi Medical Inc. System for treating gastroesophageal reflux disease
US8663254B2 (en) 2004-05-07 2014-03-04 Technische Universitaet Muenchen Blind rivet for adapting biological tissue and device for setting the same, in particular through the instrument channel of an endoscope
US8075569B2 (en) * 2004-06-11 2011-12-13 Selis James E Biopsy devices and methods
US20100292711A2 (en) * 2004-06-11 2010-11-18 James Selis Biopsy devices and methods
US8454629B2 (en) 2004-06-11 2013-06-04 James E. Selis Biopsy devices and methods
US20050277871A1 (en) * 2004-06-11 2005-12-15 Selis James E Biopsy devices and methods
US20100145363A1 (en) * 2004-06-11 2010-06-10 Selis James E Biopsy devices and methods
US8075568B2 (en) * 2004-06-11 2011-12-13 Selis James E Biopsy devices and methods
US20050288675A1 (en) * 2004-06-24 2005-12-29 Med Ideas, Llc Disk incision repair method
US10568629B2 (en) 2004-07-28 2020-02-25 Ethicon Llc Articulating surgical stapling instrument
US10799240B2 (en) 2004-07-28 2020-10-13 Ethicon Llc Surgical instrument comprising a staple firing lockout
US10687817B2 (en) 2004-07-28 2020-06-23 Ethicon Llc Stapling device comprising a firing member lockout
US11890012B2 (en) 2004-07-28 2024-02-06 Cilag Gmbh International Staple cartridge comprising cartridge body and attached support
US9737302B2 (en) 2004-07-28 2017-08-22 Ethicon Llc Surgical stapling instrument having a restraining member
US10278702B2 (en) 2004-07-28 2019-05-07 Ethicon Llc Stapling system comprising a firing bar and a lockout
US11135352B2 (en) 2004-07-28 2021-10-05 Cilag Gmbh International End effector including a gradually releasable medical adjunct
US11896225B2 (en) 2004-07-28 2024-02-13 Cilag Gmbh International Staple cartridge comprising a pan
US11083456B2 (en) 2004-07-28 2021-08-10 Cilag Gmbh International Articulating surgical instrument incorporating a two-piece firing mechanism
US9844379B2 (en) 2004-07-28 2017-12-19 Ethicon Llc Surgical stapling instrument having a clearanced opening
US9737303B2 (en) 2004-07-28 2017-08-22 Ethicon Llc Articulating surgical stapling instrument incorporating a two-piece E-beam firing mechanism
US11684365B2 (en) 2004-07-28 2023-06-27 Cilag Gmbh International Replaceable staple cartridges for surgical instruments
US10292707B2 (en) 2004-07-28 2019-05-21 Ethicon Llc Articulating surgical stapling instrument incorporating a firing mechanism
US10293100B2 (en) 2004-07-28 2019-05-21 Ethicon Llc Surgical stapling instrument having a medical substance dispenser
US9585663B2 (en) 2004-07-28 2017-03-07 Ethicon Endo-Surgery, Llc Surgical stapling instrument configured to apply a compressive pressure to tissue
US11116502B2 (en) 2004-07-28 2021-09-14 Cilag Gmbh International Surgical stapling instrument incorporating a two-piece firing mechanism
US10314590B2 (en) 2004-07-28 2019-06-11 Ethicon Llc Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism
US11812960B2 (en) 2004-07-28 2023-11-14 Cilag Gmbh International Method of segmenting the operation of a surgical stapling instrument
US10716563B2 (en) 2004-07-28 2020-07-21 Ethicon Llc Stapling system comprising an instrument assembly including a lockout
US10485547B2 (en) 2004-07-28 2019-11-26 Ethicon Llc Surgical staple cartridges
US9603991B2 (en) 2004-07-28 2017-03-28 Ethicon Endo-Surgery, Llc Surgical stapling instrument having a medical substance dispenser
US9510830B2 (en) 2004-07-28 2016-12-06 Ethicon Endo-Surgery, Llc Staple cartridge
US10383634B2 (en) 2004-07-28 2019-08-20 Ethicon Llc Stapling system incorporating a firing lockout
US9282966B2 (en) 2004-07-28 2016-03-15 Ethicon Endo-Surgery, Inc. Surgical stapling instrument
US11882987B2 (en) 2004-07-28 2024-01-30 Cilag Gmbh International Articulating surgical stapling instrument incorporating a two-piece E-beam firing mechanism
US11690627B2 (en) 2004-08-05 2023-07-04 Torax Medical, Inc. Methods and apparatus for treating body tissue sphincters and the like
US10874400B2 (en) 2004-08-05 2020-12-29 Torax Medical, Inc. Methods and apparatus for treating body tissue sphincters and the like
US20060235469A1 (en) * 2004-10-18 2006-10-19 Viola Frank J Surgical fasteners coated with wound treatment materials
US8758404B2 (en) 2004-10-18 2014-06-24 Covidien Lp Surgical fasteners coated with wound treatment materials
US8435263B2 (en) 2004-10-18 2013-05-07 Covidien Lp Surgical fasteners coated with wound treatment materials
US8097017B2 (en) 2004-10-18 2012-01-17 Tyco Healthcare Group Lp Surgical fasteners coated with wound treatment materials
US8048144B2 (en) * 2004-11-30 2011-11-01 Scimed Life Systems, Inc. Prosthesis fixation device and method
US9526500B2 (en) 2004-11-30 2016-12-27 Endogastric Solutions, Inc. Flexible transoral endoscopic gastroesophageal flap valve restoration device and method
US20060116754A1 (en) * 2004-11-30 2006-06-01 Robert Thistle Prosthesis fixation device and method
US10299814B2 (en) 2004-11-30 2019-05-28 Endogastric Solutions, Inc. Flexible transoral endoscopic gastroesophageal flap valve restoration device and method
US20100262169A1 (en) * 2005-01-25 2010-10-14 Baker Steve G Slitted tissue fixation devices and assemblies for deploying the same
US9572578B2 (en) 2005-01-25 2017-02-21 Endogastric Solutions, Inc. Slitted tissue fixation devices and assemblies for deploying the same
US9358007B2 (en) 2005-01-25 2016-06-07 Endogastric Solutions, Inc. Slitted tissue fixation devices and assemblies for deploying the same
US8337514B2 (en) 2005-01-25 2012-12-25 Endogastric Solutions, Inc. Slitted tissue fixation devices and assemblies for deploying the same
EP2756794A1 (en) * 2005-02-08 2014-07-23 Koninklijke Philips N.V. System and method for percutaneous glossoplasty
US10327793B2 (en) 2005-06-29 2019-06-25 Endogastric Solutions, Inc. Apparatus and method for manipulating stomach tissue and treating gastroesophageal reflux disease
US9259218B2 (en) 2005-07-05 2016-02-16 Mitralign, Inc. Tissue anchor and anchoring system
US8951286B2 (en) 2005-07-05 2015-02-10 Mitralign, Inc. Tissue anchor and anchoring system
US9814454B2 (en) 2005-07-05 2017-11-14 Mitralign, Inc. Tissue anchor and anchoring system
US10695046B2 (en) 2005-07-05 2020-06-30 Edwards Lifesciences Corporation Tissue anchor and anchoring system
US20090182352A1 (en) * 2005-07-06 2009-07-16 Adrian Paz Surgical Fasteners and Fastening Devices
US9241710B2 (en) 2005-07-06 2016-01-26 I.B.I Israel Biomedical Innovations Ltd. Surgical fasteners and fastening devices
WO2007004228A1 (en) * 2005-07-06 2007-01-11 Endogun Medical Systems Ltd. Surgical fasteners and fastening devices
WO2007017872A3 (en) * 2005-08-11 2007-07-05 Endogun Medical Systems Ltd Surgical fasteners and devices for surgical fastening
GB2442429A (en) * 2005-08-11 2008-04-02 Endogun Medical Systems Ltd Surgical fasteners and devices for surgical fastening
WO2007017872A2 (en) * 2005-08-11 2007-02-15 Endogun Medical Systems Ltd. Surgical fasteners and devices for surgical fastening
US10772624B2 (en) 2005-08-12 2020-09-15 Endogastric Solutions, Inc. Apparatus and method for securing the stomach to the diaphragm for use, for example, in treating hiatal hernias and gastroesophageal reflux disease
US9414832B2 (en) * 2005-08-12 2016-08-16 Endogastric Solutions, Inc. Apparatus and method for securing the stomach to the diaphragm for use, for example, in treating hiatal hernias and gastroesophageal reflux disease
US20100168507A1 (en) * 2005-08-12 2010-07-01 Kraemer Stefan J M Apparatus and method for securing the stomach to the diaphragm for use, for example, in treating hiatal hernias and gastroesophageal reflux disease
US8128552B2 (en) 2005-08-22 2012-03-06 O'donnell Pat D Surgical instrument for treating female pelvic prolapse
US20070043255A1 (en) * 2005-08-22 2007-02-22 O'donnell Pat D Surgical instrument for treating female pelvic prolapse
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US10159482B2 (en) 2005-08-31 2018-12-25 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US11134947B2 (en) 2005-08-31 2021-10-05 Cilag Gmbh International Fastener cartridge assembly comprising a camming sled with variable cam arrangements
US10278697B2 (en) 2005-08-31 2019-05-07 Ethicon Llc Staple cartridge comprising a staple driver arrangement
US9839427B2 (en) 2005-08-31 2017-12-12 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and a staple driver arrangement
US9326768B2 (en) 2005-08-31 2016-05-03 Ethicon Endo-Surgery, Llc Staple cartridges for forming staples having differing formed staple heights
US9561032B2 (en) 2005-08-31 2017-02-07 Ethicon Endo-Surgery, Llc Staple cartridge comprising a staple driver arrangement
US9844373B2 (en) 2005-08-31 2017-12-19 Ethicon Llc Fastener cartridge assembly comprising a driver row arrangement
US8317070B2 (en) 2005-08-31 2012-11-27 Ethicon Endo-Surgery, Inc. Surgical stapling devices that produce formed staples having different lengths
US10070863B2 (en) 2005-08-31 2018-09-11 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil
US11839375B2 (en) 2005-08-31 2023-12-12 Cilag Gmbh International Fastener cartridge assembly comprising an anvil and different staple heights
US11172927B2 (en) 2005-08-31 2021-11-16 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US10869664B2 (en) 2005-08-31 2020-12-22 Ethicon Llc End effector for use with a surgical stapling instrument
US8800838B2 (en) 2005-08-31 2014-08-12 Ethicon Endo-Surgery, Inc. Robotically-controlled cable-based surgical end effectors
US9848873B2 (en) 2005-08-31 2017-12-26 Ethicon Llc Fastener cartridge assembly comprising a driver and staple cavity arrangement
US11576673B2 (en) 2005-08-31 2023-02-14 Cilag Gmbh International Stapling assembly for forming staples to different heights
US10463369B2 (en) 2005-08-31 2019-11-05 Ethicon Llc Disposable end effector for use with a surgical instrument
US11484311B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US10245032B2 (en) 2005-08-31 2019-04-02 Ethicon Llc Staple cartridges for forming staples having differing formed staple heights
US10271846B2 (en) 2005-08-31 2019-04-30 Ethicon Llc Staple cartridge for use with a surgical stapler
US20070194080A1 (en) * 2005-08-31 2007-08-23 Swayze Jeffrey S Surgical stapling device with staple driver that supports multiple wire diameter staples
US8636187B2 (en) 2005-08-31 2014-01-28 Ethicon Endo-Surgery, Inc. Surgical stapling systems that produce formed staples having different lengths
US10729436B2 (en) 2005-08-31 2020-08-04 Ethicon Llc Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US20070262116A1 (en) * 2005-08-31 2007-11-15 Hueil Joseph C Surgical stapling device with multiple stacked actuator wedge cams for driving staple drivers
US10271845B2 (en) 2005-08-31 2019-04-30 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US11399828B2 (en) 2005-08-31 2022-08-02 Cilag Gmbh International Fastener cartridge assembly comprising a fixed anvil and different staple heights
US8464923B2 (en) 2005-08-31 2013-06-18 Ethicon Endo-Surgery, Inc. Surgical stapling devices for forming staples with different formed heights
US7669746B2 (en) 2005-08-31 2010-03-02 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US10420553B2 (en) 2005-08-31 2019-09-24 Ethicon Llc Staple cartridge comprising a staple driver arrangement
US9237891B2 (en) 2005-08-31 2016-01-19 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US9307988B2 (en) 2005-08-31 2016-04-12 Ethicon Endo-Surgery, Llc Staple cartridges for forming staples having differing formed staple heights
US11730474B2 (en) 2005-08-31 2023-08-22 Cilag Gmbh International Fastener cartridge assembly comprising a movable cartridge and a staple driver arrangement
US7673781B2 (en) 2005-08-31 2010-03-09 Ethicon Endo-Surgery, Inc. Surgical stapling device with staple driver that supports multiple wire diameter staples
US11090045B2 (en) 2005-08-31 2021-08-17 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US20110174863A1 (en) * 2005-08-31 2011-07-21 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US10842488B2 (en) 2005-08-31 2020-11-24 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US11771425B2 (en) 2005-08-31 2023-10-03 Cilag Gmbh International Stapling assembly for forming staples to different formed heights
US10932774B2 (en) 2005-08-31 2021-03-02 Ethicon Llc Surgical end effector for forming staples to different heights
US9592052B2 (en) 2005-08-31 2017-03-14 Ethicon Endo-Surgery, Llc Stapling assembly for forming different formed staple heights
US9795382B2 (en) 2005-08-31 2017-10-24 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US11793512B2 (en) 2005-08-31 2023-10-24 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US11179153B2 (en) 2005-08-31 2021-11-23 Cilag Gmbh International Staple cartridges for forming staples having differing formed staple heights
US10842489B2 (en) 2005-08-31 2020-11-24 Ethicon Llc Fastener cartridge assembly comprising a cam and driver arrangement
US11272928B2 (en) 2005-08-31 2022-03-15 Cilag GmbH Intemational Staple cartridges for forming staples having differing formed staple heights
US8567656B2 (en) 2005-08-31 2013-10-29 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US7934630B2 (en) 2005-08-31 2011-05-03 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US10245035B2 (en) 2005-08-31 2019-04-02 Ethicon Llc Stapling assembly configured to produce different formed staple heights
US10321909B2 (en) 2005-08-31 2019-06-18 Ethicon Llc Staple cartridge comprising a staple including deformable members
US10945716B2 (en) 2005-09-01 2021-03-16 Cordis Corporation Patent foramen ovale closure method
US8945179B2 (en) 2005-09-01 2015-02-03 Cordis Corporation Single disc occlusionary patent foramen ovale closure device
US20070083234A1 (en) * 2005-09-21 2007-04-12 Shelton Frederick E Iv Surgical stapling instruments having flexible channel and anvil features for adjustable staple heights
US9055942B2 (en) 2005-10-03 2015-06-16 Boston Scienctific Scimed, Inc. Endoscopic plication devices and methods
US20080190989A1 (en) * 2005-10-03 2008-08-14 Crews Samuel T Endoscopic plication device and method
US10299796B2 (en) 2005-10-03 2019-05-28 Boston Scientific Scimed, Inc. Endoscopic plication devices and methods
US8469977B2 (en) 2005-10-03 2013-06-25 Barosense, Inc. Endoscopic plication device and method
US9675360B2 (en) 2005-10-18 2017-06-13 Endogastric Solutions, Inc. Invaginator for gastroesophageal flap valve restoration device
US9895147B2 (en) 2005-11-09 2018-02-20 Ethicon Llc End effectors for surgical staplers
US7799039B2 (en) 2005-11-09 2010-09-21 Ethicon Endo-Surgery, Inc. Surgical instrument having a hydraulically actuated end effector
US20100179382A1 (en) * 2005-11-09 2010-07-15 Ethicon Endo-Surgery, Inc. Hydraulically and electrically actuated articulation joints for surgical instruments
US9968356B2 (en) 2005-11-09 2018-05-15 Ethicon Llc Surgical instrument drive systems
US11793511B2 (en) 2005-11-09 2023-10-24 Cilag Gmbh International Surgical instruments
US10993713B2 (en) 2005-11-09 2021-05-04 Ethicon Llc Surgical instruments
US10149679B2 (en) 2005-11-09 2018-12-11 Ethicon Llc Surgical instrument comprising drive systems
US20070106317A1 (en) * 2005-11-09 2007-05-10 Shelton Frederick E Iv Hydraulically and electrically actuated articulation joints for surgical instruments
US10028742B2 (en) 2005-11-09 2018-07-24 Ethicon Llc Staple cartridge comprising staples with different unformed heights
US20070102473A1 (en) * 2005-11-09 2007-05-10 Shelton Frederick E Iv Surgical instrument having a hydraulically actuated end effector
US10806449B2 (en) 2005-11-09 2020-10-20 Ethicon Llc End effectors for surgical staplers
US8858571B2 (en) 2005-11-09 2014-10-14 Ethicon Endo-Surgery, Inc. Hydraulically and electrically actuated articulation joints for surgical instruments
US8845512B2 (en) 2005-11-14 2014-09-30 C. R. Bard, Inc. Sling anchor system
US9987118B2 (en) 2005-12-01 2018-06-05 Endogastric Solutions, Inc. Apparatus and method for concurrently forming a gastroesophageal valve and tightening the lower esophageal sphincter
US8726909B2 (en) 2006-01-27 2014-05-20 Usgi Medical, Inc. Methods and apparatus for revision of obesity procedures
US10499890B2 (en) 2006-01-31 2019-12-10 Ethicon Llc Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US9451958B2 (en) 2006-01-31 2016-09-27 Ethicon Endo-Surgery, Llc Surgical instrument with firing actuator lockout
US10278722B2 (en) 2006-01-31 2019-05-07 Ethicon Llc Motor-driven surgical cutting and fastening instrument
US10299817B2 (en) 2006-01-31 2019-05-28 Ethicon Llc Motor-driven fastening assembly
US9320520B2 (en) 2006-01-31 2016-04-26 Ethicon Endo-Surgery, Inc. Surgical instrument system
US11801051B2 (en) 2006-01-31 2023-10-31 Cilag Gmbh International Accessing data stored in a memory of a surgical instrument
US10335144B2 (en) 2006-01-31 2019-07-02 Ethicon Llc Surgical instrument
US9326769B2 (en) 2006-01-31 2016-05-03 Ethicon Endo-Surgery, Llc Surgical instrument
US10342533B2 (en) 2006-01-31 2019-07-09 Ethicon Llc Surgical instrument
US8746529B2 (en) 2006-01-31 2014-06-10 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US9326770B2 (en) 2006-01-31 2016-05-03 Ethicon Endo-Surgery, Llc Surgical instrument
US11058420B2 (en) 2006-01-31 2021-07-13 Cilag Gmbh International Surgical stapling apparatus comprising a lockout system
US8752747B2 (en) 2006-01-31 2014-06-17 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
US10201363B2 (en) 2006-01-31 2019-02-12 Ethicon Llc Motor-driven surgical instrument
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11051813B2 (en) 2006-01-31 2021-07-06 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US11883020B2 (en) 2006-01-31 2024-01-30 Cilag Gmbh International Surgical instrument having a feedback system
US9370358B2 (en) 2006-01-31 2016-06-21 Ethicon Endo-Surgery, Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US9113874B2 (en) 2006-01-31 2015-08-25 Ethicon Endo-Surgery, Inc. Surgical instrument system
US11051811B2 (en) 2006-01-31 2021-07-06 Ethicon Llc End effector for use with a surgical instrument
US11166717B2 (en) 2006-01-31 2021-11-09 Cilag Gmbh International Surgical instrument with firing lockout
US9439649B2 (en) 2006-01-31 2016-09-13 Ethicon Endo-Surgery, Llc Surgical instrument having force feedback capabilities
US8763879B2 (en) 2006-01-31 2014-07-01 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of surgical instrument
US11020113B2 (en) 2006-01-31 2021-06-01 Cilag Gmbh International Surgical instrument having force feedback capabilities
US10426463B2 (en) 2006-01-31 2019-10-01 Ehticon LLC Surgical instrument having a feedback system
US9517068B2 (en) 2006-01-31 2016-12-13 Ethicon Endo-Surgery, Llc Surgical instrument with automatically-returned firing member
US10463384B2 (en) 2006-01-31 2019-11-05 Ethicon Llc Stapling assembly
US10463383B2 (en) 2006-01-31 2019-11-05 Ethicon Llc Stapling instrument including a sensing system
US11000275B2 (en) 2006-01-31 2021-05-11 Ethicon Llc Surgical instrument
US10993717B2 (en) 2006-01-31 2021-05-04 Ethicon Llc Surgical stapling system comprising a control system
US10098636B2 (en) 2006-01-31 2018-10-16 Ethicon Llc Surgical instrument having force feedback capabilities
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US11224454B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10959722B2 (en) 2006-01-31 2021-03-30 Ethicon Llc Surgical instrument for deploying fasteners by way of rotational motion
US11246616B2 (en) 2006-01-31 2022-02-15 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US8820603B2 (en) 2006-01-31 2014-09-02 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US8820605B2 (en) 2006-01-31 2014-09-02 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical instruments
US10952728B2 (en) 2006-01-31 2021-03-23 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US11890029B2 (en) 2006-01-31 2024-02-06 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument
US10485539B2 (en) 2006-01-31 2019-11-26 Ethicon Llc Surgical instrument with firing lockout
US8292155B2 (en) 2006-01-31 2012-10-23 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10918380B2 (en) 2006-01-31 2021-02-16 Ethicon Llc Surgical instrument system including a control system
US11660110B2 (en) 2006-01-31 2023-05-30 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US8844789B2 (en) 2006-01-31 2014-09-30 Ethicon Endo-Surgery, Inc. Automated end effector component reloading system for use with a robotic system
US11103269B2 (en) 2006-01-31 2021-08-31 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US11890008B2 (en) 2006-01-31 2024-02-06 Cilag Gmbh International Surgical instrument with firing lockout
US11648008B2 (en) 2006-01-31 2023-05-16 Cilag Gmbh International Surgical instrument having force feedback capabilities
US11648024B2 (en) 2006-01-31 2023-05-16 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with position feedback
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US8186555B2 (en) 2006-01-31 2012-05-29 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with mechanical closure system
US10893853B2 (en) 2006-01-31 2021-01-19 Ethicon Llc Stapling assembly including motor drive systems
US11350916B2 (en) 2006-01-31 2022-06-07 Cilag Gmbh International Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US10058963B2 (en) 2006-01-31 2018-08-28 Ethicon Llc Automated end effector component reloading system for use with a robotic system
US10052100B2 (en) 2006-01-31 2018-08-21 Ethicon Llc Surgical instrument system configured to detect resistive forces experienced by a tissue cutting implement
US9743928B2 (en) 2006-01-31 2017-08-29 Ethicon Endo-Surgery, Inc. Surgical instrument having a feedback system
US10052099B2 (en) 2006-01-31 2018-08-21 Ethicon Llc Surgical instrument system comprising a firing system including a rotatable shaft and first and second actuation ramps
US8172124B2 (en) 2006-01-31 2012-05-08 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
US8167185B2 (en) 2006-01-31 2012-05-01 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
US8161977B2 (en) 2006-01-31 2012-04-24 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US10010322B2 (en) 2006-01-31 2018-07-03 Ethicon Llc Surgical instrument
US11364046B2 (en) 2006-01-31 2022-06-21 Cilag Gmbh International Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10004498B2 (en) 2006-01-31 2018-06-26 Ethicon Llc Surgical instrument comprising a plurality of articulation joints
US8157153B2 (en) 2006-01-31 2012-04-17 Ethicon Endo-Surgery, Inc. Surgical instrument with force-feedback capabilities
US10842491B2 (en) 2006-01-31 2020-11-24 Ethicon Llc Surgical system with an actuation console
US10806479B2 (en) 2006-01-31 2020-10-20 Ethicon Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US10743849B2 (en) 2006-01-31 2020-08-18 Ethicon Llc Stapling system including an articulation system
US10709468B2 (en) 2006-01-31 2020-07-14 Ethicon Llc Motor-driven surgical cutting and fastening instrument
US10675028B2 (en) 2006-01-31 2020-06-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US20110174860A1 (en) * 2006-01-31 2011-07-21 Ethicon Endo-Surgery, Inc. Surgical instrument with force-feedback capabilities
US10653417B2 (en) 2006-01-31 2020-05-19 Ethicon Llc Surgical instrument
US11612393B2 (en) 2006-01-31 2023-03-28 Cilag Gmbh International Robotically-controlled end effector
US10653435B2 (en) 2006-01-31 2020-05-19 Ethicon Llc Motor-driven surgical cutting and fastening instrument with tactile position feedback
US9861359B2 (en) 2006-01-31 2018-01-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
US9492167B2 (en) 2006-03-23 2016-11-15 Ethicon Endo-Surgery, Llc Articulatable surgical device with rotary driven cutting member
US10070861B2 (en) 2006-03-23 2018-09-11 Ethicon Llc Articulatable surgical device
US10064688B2 (en) 2006-03-23 2018-09-04 Ethicon Llc Surgical system with selectively articulatable end effector
US9402626B2 (en) 2006-03-23 2016-08-02 Ethicon Endo-Surgery, Llc Rotary actuatable surgical fastener and cutter
US9149274B2 (en) 2006-03-23 2015-10-06 Ethicon Endo-Surgery, Inc. Articulating endoscopic accessory channel
US8911471B2 (en) 2006-03-23 2014-12-16 Ethicon Endo-Surgery, Inc. Articulatable surgical device
US10213262B2 (en) 2006-03-23 2019-02-26 Ethicon Llc Manipulatable surgical systems with selectively articulatable fastening device
US9301759B2 (en) 2006-03-23 2016-04-05 Ethicon Endo-Surgery, Llc Robotically-controlled surgical instrument with selectively articulatable end effector
US20080058887A1 (en) * 2006-04-25 2008-03-06 Bobby Griffin Methods and devices for gastrointestinal stimulation
US7881797B2 (en) 2006-04-25 2011-02-01 Valentx, Inc. Methods and devices for gastrointestinal stimulation
US20080015636A1 (en) * 2006-06-09 2008-01-17 Daniel Olsen Single disc intraluminal patent foramen ovale closure device
US20080015635A1 (en) * 2006-06-09 2008-01-17 Daniel Olsen Single disc occlusionary patent foramen ovale closure device
US20090281568A1 (en) * 2006-06-14 2009-11-12 Juan Carlos Cendan Devices and Methods for Adjustable, Knotless Tissue Approximation
US9320521B2 (en) 2006-06-27 2016-04-26 Ethicon Endo-Surgery, Llc Surgical instrument
US10420560B2 (en) 2006-06-27 2019-09-24 Ethicon Llc Manually driven surgical cutting and fastening instrument
US10314589B2 (en) 2006-06-27 2019-06-11 Ethicon Llc Surgical instrument including a shifting assembly
US11272938B2 (en) 2006-06-27 2022-03-15 Cilag Gmbh International Surgical instrument including dedicated firing and retraction assemblies
WO2008005261A3 (en) * 2006-07-05 2008-05-08 Wilson Cook Medical Inc Suction clip
US20080009886A1 (en) * 2006-07-05 2008-01-10 Wilson-Cook Medical Inc. Suction cup
WO2008005261A2 (en) * 2006-07-05 2008-01-10 Wilson-Cook Medical Inc. Suction clip
US7905891B2 (en) 2006-07-05 2011-03-15 Wilson-Cook Medical Inc. Suction clip
US20080195226A1 (en) * 2006-09-02 2008-08-14 Williams Michael S Intestinal sleeves and associated deployment systems and methods
US9687334B2 (en) 2006-09-02 2017-06-27 Boston Scientific Scimed, Inc. Intestinal sleeves and associated deployment systems and methods
US8109895B2 (en) 2006-09-02 2012-02-07 Barosense, Inc. Intestinal sleeves and associated deployment systems and methods
US8480559B2 (en) 2006-09-13 2013-07-09 C. R. Bard, Inc. Urethral support system
US20090125040A1 (en) * 2006-09-13 2009-05-14 Hambly Pablo R Tissue acquisition devices and methods
US9314361B2 (en) * 2006-09-15 2016-04-19 Boston Scientific Scimed, Inc. System and method for anchoring stomach implant
US20080208355A1 (en) * 2006-09-15 2008-08-28 Stack Richard S System and method for anchoring stomach implant
WO2008036874A3 (en) * 2006-09-21 2008-05-22 Scott G Edwards System and method of bone compression and fixation
WO2008036874A2 (en) * 2006-09-21 2008-03-27 Edwards Scott G System and method of bone compression and fixation
US20080077154A1 (en) * 2006-09-21 2008-03-27 Edwards Scott G System and method of bone compression and fixation
US8317795B2 (en) 2006-09-21 2012-11-27 Scott G. Edwards System and method of bone compression and fixation
US7665647B2 (en) 2006-09-29 2010-02-23 Ethicon Endo-Surgery, Inc. Surgical cutting and stapling device with closure apparatus for limiting maximum tissue compression force
US8720766B2 (en) 2006-09-29 2014-05-13 Ethicon Endo-Surgery, Inc. Surgical stapling instruments and staples
US10130359B2 (en) 2006-09-29 2018-11-20 Ethicon Llc Method for forming a staple
US8499993B2 (en) 2006-09-29 2013-08-06 Ethicon Endo-Surgery, Inc. Surgical staple cartridge
US10448952B2 (en) 2006-09-29 2019-10-22 Ethicon Llc End effector for use with a surgical fastening instrument
US8220690B2 (en) 2006-09-29 2012-07-17 Ethicon Endo-Surgery, Inc. Connected surgical staples and stapling instruments for deploying the same
US9603595B2 (en) 2006-09-29 2017-03-28 Ethicon Endo-Surgery, Llc Surgical instrument comprising an adjustable system configured to accommodate different jaw heights
US7966799B2 (en) 2006-09-29 2011-06-28 Ethicon Endo-Surgery, Inc. Method of manufacturing staples
US10595862B2 (en) 2006-09-29 2020-03-24 Ethicon Llc Staple cartridge including a compressible member
US9706991B2 (en) 2006-09-29 2017-07-18 Ethicon Endo-Surgery, Inc. Staple cartridge comprising staples including a lateral base
US8763875B2 (en) 2006-09-29 2014-07-01 Ethicon Endo-Surgery, Inc. End effector for use with a surgical fastening instrument
US8973804B2 (en) 2006-09-29 2015-03-10 Ethicon Endo-Surgery, Inc. Cartridge assembly having a buttressing member
US8485412B2 (en) 2006-09-29 2013-07-16 Ethicon Endo-Surgery, Inc. Surgical staples having attached drivers and stapling instruments for deploying the same
US11622785B2 (en) 2006-09-29 2023-04-11 Cilag Gmbh International Surgical staples having attached drivers and stapling instruments for deploying the same
US10172616B2 (en) 2006-09-29 2019-01-08 Ethicon Llc Surgical staple cartridge
US7794475B2 (en) 2006-09-29 2010-09-14 Ethicon Endo-Surgery, Inc. Surgical staples having compressible or crushable members for securing tissue therein and stapling instruments for deploying the same
US8365976B2 (en) 2006-09-29 2013-02-05 Ethicon Endo-Surgery, Inc. Surgical staples having dissolvable, bioabsorbable or biofragmentable portions and stapling instruments for deploying the same
US8360297B2 (en) 2006-09-29 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical cutting and stapling instrument with self adjusting anvil
US9408604B2 (en) 2006-09-29 2016-08-09 Ethicon Endo-Surgery, Llc Surgical instrument comprising a firing system including a compliant portion
US11678876B2 (en) 2006-09-29 2023-06-20 Cilag Gmbh International Powered surgical instrument
US10568652B2 (en) 2006-09-29 2020-02-25 Ethicon Llc Surgical staples having attached drivers of different heights and stapling instruments for deploying the same
US10695053B2 (en) 2006-09-29 2020-06-30 Ethicon Llc Surgical end effectors with staple cartridges
US8899465B2 (en) 2006-09-29 2014-12-02 Ethicon Endo-Surgery, Inc. Staple cartridge comprising drivers for deploying a plurality of staples
US11571231B2 (en) 2006-09-29 2023-02-07 Cilag Gmbh International Staple cartridge having a driver for driving multiple staples
US9179911B2 (en) 2006-09-29 2015-11-10 Ethicon Endo-Surgery, Inc. End effector for use with a surgical fastening instrument
US11633182B2 (en) 2006-09-29 2023-04-25 Cilag Gmbh International Surgical stapling assemblies
US20080078804A1 (en) * 2006-09-29 2008-04-03 Shelton Frederick E Surgical cutting and stapling instrument with self adjusting anvil
US8808325B2 (en) 2006-09-29 2014-08-19 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with staples having crown features for increasing formed staple footprint
US8348131B2 (en) 2006-09-29 2013-01-08 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with mechanical indicator to show levels of tissue compression
US20080082124A1 (en) * 2006-09-29 2008-04-03 Hess Christopher J Surgical staples having compressible or crushable members for securing tissue therein and stapling instruments for deploying the same
WO2008039270A1 (en) * 2006-09-29 2008-04-03 Ethicon Endo-Surgery, Inc. Surgical staples having compressible or crushable members for securing tissue therein and stapling instruments for deploying the same
US20080082115A1 (en) * 2006-09-29 2008-04-03 Morgan Jerome R Method of manufacturing staples
US11406379B2 (en) 2006-09-29 2022-08-09 Cilag Gmbh International Surgical end effectors with staple cartridges
US10206678B2 (en) 2006-10-03 2019-02-19 Ethicon Llc Surgical stapling instrument with lockout features to prevent advancement of a firing assembly unless an unfired surgical staple cartridge is operably mounted in an end effector portion of the instrument
US10342541B2 (en) 2006-10-03 2019-07-09 Ethicon Llc Surgical instruments with E-beam driver and rotary drive arrangements
US11382626B2 (en) 2006-10-03 2022-07-12 Cilag Gmbh International Surgical system including a knife bar supported for rotational and axial travel
US11877748B2 (en) 2006-10-03 2024-01-23 Cilag Gmbh International Robotically-driven surgical instrument with E-beam driver
US8926641B2 (en) * 2006-10-04 2015-01-06 Ethicon Endo-Surgery, Inc. Methods and devices for reconfiguring a body organ
US8882789B2 (en) 2006-10-04 2014-11-11 Ethicon Endo-Surgery, Inc. Methods and systems for tissue manipulation
US20080312750A1 (en) * 2006-10-04 2008-12-18 Michael Laufer Methods and devices for reconfiguring a body organ
US20090018389A1 (en) * 2006-10-04 2009-01-15 Michael Laufer Methods and systems for tissue manipulation
US9788829B2 (en) 2007-01-08 2017-10-17 Endogastric Solutions, Inc. Connected fasteners, delivery device and method
US9421006B2 (en) 2007-01-08 2016-08-23 Endogastric Solutions, Inc. Connected fasteners, delivery device and method
US10517590B2 (en) 2007-01-10 2019-12-31 Ethicon Llc Powered surgical instrument having a transmission system
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US11000277B2 (en) 2007-01-10 2021-05-11 Ethicon Llc Surgical instrument with wireless communication between control unit and remote sensor
US10433918B2 (en) 2007-01-10 2019-10-08 Ethicon Llc Surgical instrument system configured to evaluate the load applied to a firing member at the initiation of a firing stroke
US11006951B2 (en) 2007-01-10 2021-05-18 Ethicon Llc Surgical instrument with wireless communication between control unit and sensor transponders
US10952727B2 (en) 2007-01-10 2021-03-23 Ethicon Llc Surgical instrument for assessing the state of a staple cartridge
US10441369B2 (en) 2007-01-10 2019-10-15 Ethicon Llc Articulatable surgical instrument configured for detachable use with a robotic system
US8479969B2 (en) 2007-01-10 2013-07-09 Ethicon Endo-Surgery, Inc. Drive interface for operably coupling a manipulatable surgical tool to a robot
US10945729B2 (en) 2007-01-10 2021-03-16 Ethicon Llc Interlock and surgical instrument including same
US11771426B2 (en) 2007-01-10 2023-10-03 Cilag Gmbh International Surgical instrument with wireless communication
US11350929B2 (en) 2007-01-10 2022-06-07 Cilag Gmbh International Surgical instrument with wireless communication between control unit and sensor transponders
US8517243B2 (en) 2007-01-10 2013-08-27 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and remote sensor
US10751138B2 (en) 2007-01-10 2020-08-25 Ethicon Llc Surgical instrument for use with a robotic system
US11849947B2 (en) 2007-01-10 2023-12-26 Cilag Gmbh International Surgical system including a control circuit and a passively-powered transponder
US10918386B2 (en) 2007-01-10 2021-02-16 Ethicon Llc Interlock and surgical instrument including same
US11812961B2 (en) 2007-01-10 2023-11-14 Cilag Gmbh International Surgical instrument including a motor control system
US11666332B2 (en) 2007-01-10 2023-06-06 Cilag Gmbh International Surgical instrument comprising a control circuit configured to adjust the operation of a motor
US11166720B2 (en) 2007-01-10 2021-11-09 Cilag Gmbh International Surgical instrument including a control module for assessing an end effector
US8459520B2 (en) 2007-01-10 2013-06-11 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and remote sensor
US8652120B2 (en) 2007-01-10 2014-02-18 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US8684253B2 (en) 2007-01-10 2014-04-01 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US10517682B2 (en) 2007-01-10 2019-12-31 Ethicon Llc Surgical instrument with wireless communication between control unit and remote sensor
US8840603B2 (en) 2007-01-10 2014-09-23 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US10278780B2 (en) 2007-01-10 2019-05-07 Ethicon Llc Surgical instrument for use with robotic system
US11844521B2 (en) 2007-01-10 2023-12-19 Cilag Gmbh International Surgical instrument for use with a robotic system
US9757123B2 (en) 2007-01-10 2017-09-12 Ethicon Llc Powered surgical instrument having a transmission system
US11134943B2 (en) 2007-01-10 2021-10-05 Cilag Gmbh International Powered surgical instrument including a control unit and sensor
US11064998B2 (en) 2007-01-10 2021-07-20 Cilag Gmbh International Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US8746530B2 (en) 2007-01-10 2014-06-10 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and remote sensor
US10912575B2 (en) 2007-01-11 2021-02-09 Ethicon Llc Surgical stapling device having supports for a flexible drive mechanism
US9603598B2 (en) 2007-01-11 2017-03-28 Ethicon Endo-Surgery, Llc Surgical stapling device with a curved end effector
US9730692B2 (en) 2007-01-11 2017-08-15 Ethicon Llc Surgical stapling device with a curved staple cartridge
US9655624B2 (en) 2007-01-11 2017-05-23 Ethicon Llc Surgical stapling device with a curved end effector
US9724091B2 (en) 2007-01-11 2017-08-08 Ethicon Llc Surgical stapling device
US9999431B2 (en) 2007-01-11 2018-06-19 Ethicon Endo-Surgery, Llc Surgical stapling device having supports for a flexible drive mechanism
US9700321B2 (en) 2007-01-11 2017-07-11 Ethicon Llc Surgical stapling device having supports for a flexible drive mechanism
US9750501B2 (en) 2007-01-11 2017-09-05 Ethicon Endo-Surgery, Llc Surgical stapling devices having laterally movable anvils
US8540128B2 (en) 2007-01-11 2013-09-24 Ethicon Endo-Surgery, Inc. Surgical stapling device with a curved end effector
US11839352B2 (en) 2007-01-11 2023-12-12 Cilag Gmbh International Surgical stapling device with an end effector
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US9675355B2 (en) 2007-01-11 2017-06-13 Ethicon Llc Surgical stapling device with a curved end effector
US9775613B2 (en) 2007-01-11 2017-10-03 Ethicon Llc Surgical stapling device with a curved end effector
US9757130B2 (en) 2007-02-28 2017-09-12 Ethicon Llc Stapling assembly for forming different formed staple heights
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
US9750608B2 (en) 2007-03-13 2017-09-05 Mitralign, Inc. Systems and methods for introducing elements into tissue
US8845723B2 (en) 2007-03-13 2014-09-30 Mitralign, Inc. Systems and methods for introducing elements into tissue
US8911461B2 (en) 2007-03-13 2014-12-16 Mitralign, Inc. Suture cutter and method of cutting suture
US9358111B2 (en) 2007-03-13 2016-06-07 Mitralign, Inc. Tissue anchors, systems and methods, and devices
US8668130B2 (en) 2007-03-15 2014-03-11 Ethicon Endo-Surgery, Inc. Surgical stapling systems and staple cartridges for deploying surgical staples with tissue compression features
US9289206B2 (en) 2007-03-15 2016-03-22 Ethicon Endo-Surgery, Llc Lateral securement members for surgical staple cartridges
US8925788B2 (en) 2007-03-15 2015-01-06 Ethicon Endo-Surgery, Inc. End effectors for surgical stapling instruments
US8186560B2 (en) 2007-03-15 2012-05-29 Ethicon Endo-Surgery, Inc. Surgical stapling systems and staple cartridges for deploying surgical staples with tissue compression features
US7673782B2 (en) 2007-03-15 2010-03-09 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having a releasable buttress material
US8727197B2 (en) 2007-03-15 2014-05-20 Ethicon Endo-Surgery, Inc. Staple cartridge cavity configuration with cooperative surgical staple
US8672208B2 (en) 2007-03-15 2014-03-18 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having a releasable buttress material
US9872682B2 (en) 2007-03-15 2018-01-23 Ethicon Llc Surgical stapling instrument having a releasable buttress material
US10702267B2 (en) 2007-03-15 2020-07-07 Ethicon Llc Surgical stapling instrument having a releasable buttress material
US7669747B2 (en) 2007-03-15 2010-03-02 Ethicon Endo-Surgery, Inc. Washer for use with a surgical stapling instrument
US8590762B2 (en) 2007-03-15 2013-11-26 Ethicon Endo-Surgery, Inc. Staple cartridge cavity configurations
US11337693B2 (en) 2007-03-15 2022-05-24 Cilag Gmbh International Surgical stapling instrument having a releasable buttress material
US8991676B2 (en) 2007-03-15 2015-03-31 Ethicon Endo-Surgery, Inc. Surgical staple having a slidable crown
US7735703B2 (en) 2007-03-15 2010-06-15 Ethicon Endo-Surgery, Inc. Re-loadable surgical stapling instrument
US20080228199A1 (en) * 2007-03-16 2008-09-18 Ethicon Endo-Surgery, Inc. Endoscopic tissue approximation method
US20080228202A1 (en) * 2007-03-16 2008-09-18 Ethicon Endo-Surgery, Inc. Endoscopic tissue approximation system
US20080234703A1 (en) * 2007-03-23 2008-09-25 Ethicon Endo-Surgery, Inc. Tissue approximation system
US8852216B2 (en) 2007-03-23 2014-10-07 Ethicon Endo-Surgery, Inc. Tissue approximation methods
US8893946B2 (en) 2007-03-28 2014-11-25 Ethicon Endo-Surgery, Inc. Laparoscopic tissue thickness and clamp load measuring devices
US10398433B2 (en) 2007-03-28 2019-09-03 Ethicon Llc Laparoscopic clamp load measuring devices
US20080243182A1 (en) * 2007-03-29 2008-10-02 Datascope Investment Corp. Vascular hemostasis device and deployment apparatus
US8080034B2 (en) * 2007-03-29 2011-12-20 St. Jude Medical, Inc. Vascular hemostasis device and deployment apparatus
US10485525B2 (en) 2007-04-05 2019-11-26 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
US9005242B2 (en) 2007-04-05 2015-04-14 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
US20080249562A1 (en) * 2007-04-05 2008-10-09 Nmt Medical, Inc. Septal closure device with centering mechanism
US9949728B2 (en) 2007-04-05 2018-04-24 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
US20080294179A1 (en) * 2007-05-12 2008-11-27 Balbierz Daniel J Devices and methods for stomach partitioning
US8534528B2 (en) 2007-06-04 2013-09-17 Ethicon Endo-Surgery, Inc. Surgical instrument having a multiple rate directional switching mechanism
US10327765B2 (en) 2007-06-04 2019-06-25 Ethicon Llc Drive systems for surgical instruments
US10299787B2 (en) 2007-06-04 2019-05-28 Ethicon Llc Stapling system comprising rotary inputs
US9186143B2 (en) 2007-06-04 2015-11-17 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
US8424740B2 (en) 2007-06-04 2013-04-23 Ethicon Endo-Surgery, Inc. Surgical instrument having a directional switching mechanism
US11147549B2 (en) 2007-06-04 2021-10-19 Cilag Gmbh International Stapling instrument including a firing system and a closure system
US11911028B2 (en) 2007-06-04 2024-02-27 Cilag Gmbh International Surgical instruments for use with a robotic surgical system
US9750498B2 (en) 2007-06-04 2017-09-05 Ethicon Endo Surgery, Llc Drive systems for surgical instruments
US11154298B2 (en) 2007-06-04 2021-10-26 Cilag Gmbh International Stapling system for use with a robotic surgical system
US11564682B2 (en) 2007-06-04 2023-01-31 Cilag Gmbh International Surgical stapler device
US11672531B2 (en) 2007-06-04 2023-06-13 Cilag Gmbh International Rotary drive systems for surgical instruments
US10441280B2 (en) 2007-06-04 2019-10-15 Ethicon Llc Robotically-controlled shaft based rotary drive systems for surgical instruments
US8196796B2 (en) 2007-06-04 2012-06-12 Ethicon Endo-Surgery, Inc. Shaft based rotary drive system for surgical instruments
US11559302B2 (en) 2007-06-04 2023-01-24 Cilag Gmbh International Surgical instrument including a firing member movable at different speeds
US8931682B2 (en) 2007-06-04 2015-01-13 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
US11134938B2 (en) 2007-06-04 2021-10-05 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11857181B2 (en) 2007-06-04 2024-01-02 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US10363033B2 (en) 2007-06-04 2019-07-30 Ethicon Llc Robotically-controlled surgical instruments
US8616431B2 (en) 2007-06-04 2013-12-31 Ethicon Endo-Surgery, Inc. Shiftable drive interface for robotically-controlled surgical tool
US9795381B2 (en) 2007-06-04 2017-10-24 Ethicon Endo-Surgery, Llc Robotically-controlled shaft based rotary drive systems for surgical instruments
US10368863B2 (en) 2007-06-04 2019-08-06 Ethicon Llc Robotically-controlled shaft based rotary drive systems for surgical instruments
US9987003B2 (en) 2007-06-04 2018-06-05 Ethicon Llc Robotic actuator assembly
US9585658B2 (en) 2007-06-04 2017-03-07 Ethicon Endo-Surgery, Llc Stapling systems
US11648006B2 (en) 2007-06-04 2023-05-16 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US20130110228A1 (en) * 2007-06-08 2013-05-02 St. Jude Medical, Inc Devices for transcatheter prosthetic heart valve implantation and access closure
US20090012553A1 (en) * 2007-06-08 2009-01-08 Valentx, Inc. Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US8915958B2 (en) * 2007-06-08 2014-12-23 St. Jude Medical, Inc. Devices for transcatheter prosthetic heart valve implantation and access closure
US20080306496A1 (en) * 2007-06-08 2008-12-11 Regner Justin L Physiologic abdominal closure
US9101357B2 (en) 2007-06-08 2015-08-11 Board Of Trustees Of The University Of Arkansas Physiologic abdominal closure
WO2008153616A1 (en) * 2007-06-08 2008-12-18 Board Of Trustees Of The University Of Arkansas Physiologic abdominal closure
US20090012544A1 (en) * 2007-06-08 2009-01-08 Valen Tx, Inc. Gastrointestinal bypass sleeve as an adjunct to bariatric surgery
US8182441B2 (en) 2007-06-08 2012-05-22 Valentx, Inc. Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US20090012356A1 (en) * 2007-06-11 2009-01-08 Valen Tx, Inc. Endoscopic delivery devices and methods
US9138225B2 (en) 2007-06-22 2015-09-22 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with an articulatable end effector
US9662110B2 (en) 2007-06-22 2017-05-30 Ethicon Endo-Surgery, Llc Surgical stapling instrument with an articulatable end effector
US11013511B2 (en) 2007-06-22 2021-05-25 Ethicon Llc Surgical stapling instrument with an articulatable end effector
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US9545249B2 (en) 2007-07-18 2017-01-17 Boston Scientific Scimed, Inc. Overtube introducer for use in endoscopic bariatric surgery
US9456825B2 (en) * 2007-07-18 2016-10-04 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US20090030284A1 (en) * 2007-07-18 2009-01-29 David Cole Overtube introducer for use in endoscopic bariatric surgery
US20170000637A1 (en) * 2007-07-18 2017-01-05 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US10537456B2 (en) * 2007-07-18 2020-01-21 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US20130304094A1 (en) * 2007-07-18 2013-11-14 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US20090024143A1 (en) * 2007-07-18 2009-01-22 Crews Samuel T Endoscopic implant system and method
US20090069822A1 (en) * 2007-09-10 2009-03-12 Olympus Medical Systems Corp. Tissue fastening tool, stent, applicator for placing the same, and tissue fastening method through natural orifice
EP2033584A1 (en) 2007-09-10 2009-03-11 Olympus Medical Systems Corporation Tissue fastening tool, stent and applicator for indweling the same within body, and tissue fastening method through natural orifice
US8858576B2 (en) 2007-09-10 2014-10-14 Olympus Medical Systems Corp. Tissue fastening tool, stent, applicator for placing the same, and tissue fastening method through natural orifice
US20090088795A1 (en) * 2007-09-28 2009-04-02 Nmt Medical, Inc. Catch Member for Septal Occluder with Adjustable-Length Center Joint
US8715319B2 (en) * 2007-09-28 2014-05-06 W.L. Gore & Associates, Inc. Catch member for septal occluder with adjustable-length center joint
AU2008312339B2 (en) * 2007-10-19 2014-04-24 Cardinal Health 529, Llc Push-in retainer system for use in the direct plication annuloplasty treatment of mitral valve regurgitation
US20090105816A1 (en) * 2007-10-19 2009-04-23 Olsen Daniel H System using a helical retainer in the direct plication annuloplasty treatment of mitral valve regurgitation
US20100076408A1 (en) * 2007-10-19 2010-03-25 Matthew Krever Deflecting guide catheter for use in a minimally invasive medical procedure for the treatment of mitral valve regurgitation
US20130172990A1 (en) * 2007-10-19 2013-07-04 Adam Groothuis Method and system for plicating tissue in a minimally invasive medical procedure for the treatment of mitral valve regurgitation
US8197464B2 (en) 2007-10-19 2012-06-12 Cordis Corporation Deflecting guide catheter for use in a minimally invasive medical procedure for the treatment of mitral valve regurgitation
US20090105815A1 (en) * 2007-10-19 2009-04-23 Matthew Krever Push-in retainer system for use in the direct plication annuloplasty treatment of mitral valve regurgitation
US8226709B2 (en) 2007-10-19 2012-07-24 Cordis Corporation Method and system for plicating tissue in a minimally invasive medical procedure for the treatment of mitral valve regurgitation
US8574149B2 (en) 2007-11-13 2013-11-05 C. R. Bard, Inc. Adjustable tissue support member
US8206280B2 (en) 2007-11-13 2012-06-26 C. R. Bard, Inc. Adjustable tissue support member
US20090171383A1 (en) * 2007-12-31 2009-07-02 David Cole Gastric space occupier systems and methods of use
US8945167B2 (en) 2007-12-31 2015-02-03 Boston Scientific Scimed, Inc. Gastric space occupier systems and methods of use
US8545573B2 (en) 2008-02-12 2013-10-01 Cook Medical Technologies Llc Spiral occluding device with an occlusion sail
US20090204145A1 (en) * 2008-02-12 2009-08-13 Cook Incorporated Spiral occluding device with an occlusion sail
US10765424B2 (en) 2008-02-13 2020-09-08 Ethicon Llc Surgical stapling instrument
US9179912B2 (en) 2008-02-14 2015-11-10 Ethicon Endo-Surgery, Inc. Robotically-controlled motorized surgical cutting and fastening instrument
US10905426B2 (en) 2008-02-14 2021-02-02 Ethicon Llc Detachable motor powered surgical instrument
US11638583B2 (en) 2008-02-14 2023-05-02 Cilag Gmbh International Motorized surgical system having a plurality of power sources
US10265067B2 (en) 2008-02-14 2019-04-23 Ethicon Llc Surgical instrument including a regulator and a control system
US9901346B2 (en) 2008-02-14 2018-02-27 Ethicon Llc Stapling assembly
US10542974B2 (en) 2008-02-14 2020-01-28 Ethicon Llc Surgical instrument including a control system
US10806450B2 (en) 2008-02-14 2020-10-20 Ethicon Llc Surgical cutting and fastening instrument having a control system
US8459525B2 (en) 2008-02-14 2013-06-11 Ethicon Endo-Sugery, Inc. Motorized surgical cutting and fastening instrument having a magnetic drive train torque limiting device
US10238387B2 (en) 2008-02-14 2019-03-26 Ethicon Llc Surgical instrument comprising a control system
US10238385B2 (en) 2008-02-14 2019-03-26 Ethicon Llc Surgical instrument system for evaluating tissue impedance
US8196795B2 (en) 2008-02-14 2012-06-12 Ethicon Endo-Surgery, Inc. Disposable motor-driven loading unit for use with a surgical cutting and stapling apparatus
US8657178B2 (en) 2008-02-14 2014-02-25 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus
US8657174B2 (en) 2008-02-14 2014-02-25 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument having handle based power source
US10888329B2 (en) 2008-02-14 2021-01-12 Ethicon Llc Detachable motor powered surgical instrument
US11612395B2 (en) 2008-02-14 2023-03-28 Cilag Gmbh International Surgical system including a control system having an RFID tag reader
US10888330B2 (en) 2008-02-14 2021-01-12 Ethicon Llc Surgical system
US9204878B2 (en) 2008-02-14 2015-12-08 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US10779822B2 (en) 2008-02-14 2020-09-22 Ethicon Llc System including a surgical cutting and fastening instrument
US10206676B2 (en) 2008-02-14 2019-02-19 Ethicon Llc Surgical cutting and fastening instrument
US8636736B2 (en) 2008-02-14 2014-01-28 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument
US10639036B2 (en) 2008-02-14 2020-05-05 Ethicon Llc Robotically-controlled motorized surgical cutting and fastening instrument
US11571212B2 (en) 2008-02-14 2023-02-07 Cilag Gmbh International Surgical stapling system including an impedance sensor
US8622274B2 (en) 2008-02-14 2014-01-07 Ethicon Endo-Surgery, Inc. Motorized cutting and fastening instrument having control circuit for optimizing battery usage
US8752749B2 (en) 2008-02-14 2014-06-17 Ethicon Endo-Surgery, Inc. Robotically-controlled disposable motor-driven loading unit
US10874396B2 (en) 2008-02-14 2020-12-29 Ethicon Llc Stapling instrument for use with a surgical robot
US10898194B2 (en) 2008-02-14 2021-01-26 Ethicon Llc Detachable motor powered surgical instrument
US10743851B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Interchangeable tools for surgical instruments
US7866527B2 (en) 2008-02-14 2011-01-11 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US10660640B2 (en) 2008-02-14 2020-05-26 Ethicon Llc Motorized surgical cutting and fastening instrument
US11717285B2 (en) 2008-02-14 2023-08-08 Cilag Gmbh International Surgical cutting and fastening instrument having RF electrodes
US10307163B2 (en) 2008-02-14 2019-06-04 Ethicon Llc Detachable motor powered surgical instrument
US8758391B2 (en) 2008-02-14 2014-06-24 Ethicon Endo-Surgery, Inc. Interchangeable tools for surgical instruments
US10743870B2 (en) 2008-02-14 2020-08-18 Ethicon Llc Surgical stapling apparatus with interlockable firing system
US20090206136A1 (en) * 2008-02-14 2009-08-20 Ethicon Endo-Surgery, Inc. Disposable motor-driven loading unit for use with a surgical cutting and stapling apparatus
US7861906B2 (en) 2008-02-14 2011-01-04 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with articulatable components
US9211121B2 (en) 2008-02-14 2015-12-15 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus
US8584919B2 (en) 2008-02-14 2013-11-19 Ethicon Endo-Sugery, Inc. Surgical stapling apparatus with load-sensitive firing mechanism
US8991677B2 (en) 2008-02-14 2015-03-31 Ethicon Endo-Surgery, Inc. Detachable motor powered surgical instrument
US11801047B2 (en) 2008-02-14 2023-10-31 Cilag Gmbh International Surgical stapling system comprising a control circuit configured to selectively monitor tissue impedance and adjust control of a motor
US9980729B2 (en) 2008-02-14 2018-05-29 Ethicon Endo-Surgery, Llc Detachable motor powered surgical instrument
US10898195B2 (en) 2008-02-14 2021-01-26 Ethicon Llc Detachable motor powered surgical instrument
US8113410B2 (en) 2008-02-14 2012-02-14 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features
US8573461B2 (en) 2008-02-14 2013-11-05 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with cam-driven staple deployment arrangements
US9962158B2 (en) 2008-02-14 2018-05-08 Ethicon Llc Surgical stapling apparatuses with lockable end effector positioning systems
US8573465B2 (en) 2008-02-14 2013-11-05 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical end effector system with rotary actuated closure systems
US8973803B2 (en) 2008-02-14 2015-03-10 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
US9072515B2 (en) 2008-02-14 2015-07-07 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus
US10905427B2 (en) 2008-02-14 2021-02-02 Ethicon Llc Surgical System
US10682142B2 (en) 2008-02-14 2020-06-16 Ethicon Llc Surgical stapling apparatus including an articulation system
US8540130B2 (en) 2008-02-14 2013-09-24 Ethicon Endo-Surgery, Inc. Disposable motor-driven loading unit for use with a surgical cutting and stapling apparatus
US10682141B2 (en) 2008-02-14 2020-06-16 Ethicon Llc Surgical device including a control system
US9522029B2 (en) 2008-02-14 2016-12-20 Ethicon Endo-Surgery, Llc Motorized surgical cutting and fastening instrument having handle based power source
US10765432B2 (en) 2008-02-14 2020-09-08 Ethicon Llc Surgical device including a control system
US9084601B2 (en) 2008-02-14 2015-07-21 Ethicon Endo-Surgery, Inc. Detachable motor powered surgical instrument
US10470763B2 (en) 2008-02-14 2019-11-12 Ethicon Llc Surgical cutting and fastening instrument including a sensing system
US9095339B2 (en) 2008-02-14 2015-08-04 Ethicon Endo-Surgery, Inc. Detachable motor powered surgical instrument
US8875971B2 (en) 2008-02-14 2014-11-04 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US9498219B2 (en) 2008-02-14 2016-11-22 Ethicon Endo-Surgery, Llc Detachable motor powered surgical instrument
US11484307B2 (en) 2008-02-14 2022-11-01 Cilag Gmbh International Loading unit coupleable to a surgical stapling system
US11446034B2 (en) 2008-02-14 2022-09-20 Cilag Gmbh International Surgical stapling assembly comprising first and second actuation systems configured to perform different functions
US9877723B2 (en) 2008-02-14 2018-01-30 Ethicon Llc Surgical stapling assembly comprising a selector arrangement
US8998058B2 (en) 2008-02-14 2015-04-07 Ethicon Endo-Surgery, Inc. Detachable motor powered surgical instrument
US9867618B2 (en) 2008-02-14 2018-01-16 Ethicon Llc Surgical stapling apparatus including firing force regulation
US10925605B2 (en) 2008-02-14 2021-02-23 Ethicon Llc Surgical stapling system
US9872684B2 (en) 2008-02-14 2018-01-23 Ethicon Llc Surgical stapling apparatus including firing force regulation
US10716568B2 (en) 2008-02-14 2020-07-21 Ethicon Llc Surgical stapling apparatus with control features operable with one hand
US9901344B2 (en) 2008-02-14 2018-02-27 Ethicon Llc Stapling assembly
US10004505B2 (en) 2008-02-14 2018-06-26 Ethicon Llc Detachable motor powered surgical instrument
US7819296B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with retractable firing systems
US10722232B2 (en) 2008-02-14 2020-07-28 Ethicon Llc Surgical instrument for use with different cartridges
US9999426B2 (en) 2008-02-14 2018-06-19 Ethicon Llc Detachable motor powered surgical instrument
US10463370B2 (en) 2008-02-14 2019-11-05 Ethicon Llc Motorized surgical instrument
US11464514B2 (en) 2008-02-14 2022-10-11 Cilag Gmbh International Motorized surgical stapling system including a sensing array
US9901345B2 (en) 2008-02-14 2018-02-27 Ethicon Llc Stapling assembly
US7819297B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with reprocessible handle assembly
US7819298B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
US10856866B2 (en) 2008-02-15 2020-12-08 Ethicon Llc Surgical end effector having buttress retention features
US10390823B2 (en) 2008-02-15 2019-08-27 Ethicon Llc End effector comprising an adjunct
US11272927B2 (en) 2008-02-15 2022-03-15 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US11154297B2 (en) 2008-02-15 2021-10-26 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US9770245B2 (en) 2008-02-15 2017-09-26 Ethicon Llc Layer arrangements for surgical staple cartridges
US9585657B2 (en) 2008-02-15 2017-03-07 Ethicon Endo-Surgery, Llc Actuator for releasing a layer of material from a surgical end effector
US11058418B2 (en) 2008-02-15 2021-07-13 Cilag Gmbh International Surgical end effector having buttress retention features
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9005241B2 (en) 2008-02-18 2015-04-14 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US10695155B2 (en) 2008-02-18 2020-06-30 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US10159554B2 (en) 2008-02-18 2018-12-25 Covidien Lp Clip for implant deployment device
US10182898B2 (en) 2008-02-18 2019-01-22 Covidien Lp Clip for implant deployment device
US8753359B2 (en) 2008-02-18 2014-06-17 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9107726B2 (en) 2008-02-18 2015-08-18 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
US9474517B2 (en) 2008-03-07 2016-10-25 W. L. Gore & Associates, Inc. Heart occlusion devices
US10278705B2 (en) 2008-03-07 2019-05-07 W. L. Gore & Associates, Inc. Heart occlusion devices
US20100327042A1 (en) * 2008-03-14 2010-12-30 Amid Parviz K Hernia stapler with integrated mesh manipulator
US8827135B2 (en) 2008-03-14 2014-09-09 Transenterix, Inc. Hernia stapler with integrated mesh manipulator
US8870049B2 (en) 2008-03-14 2014-10-28 Transenterix, Inc. Hernia stapler
US20090236400A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US20090236392A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US20090236394A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US20090236389A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US7913892B2 (en) 2008-03-18 2011-03-29 Barosense, Inc. Endoscopic stapling devices and methods
US7922062B2 (en) 2008-03-18 2011-04-12 Barosense, Inc. Endoscopic stapling devices and methods
US20090236397A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US8020741B2 (en) 2008-03-18 2011-09-20 Barosense, Inc. Endoscopic stapling devices and methods
US20090236390A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US7909222B2 (en) 2008-03-18 2011-03-22 Barosense, Inc. Endoscopic stapling devices and methods
US9636114B2 (en) 2008-03-18 2017-05-02 Boston Scientific Scimed, Inc. Endoscopic stapling devices
US7909219B2 (en) 2008-03-18 2011-03-22 Barosense, Inc. Endoscopic stapling devices and methods
US7909223B2 (en) 2008-03-18 2011-03-22 Barosense, Inc. Endoscopic stapling devices and methods
US7708181B2 (en) 2008-03-18 2010-05-04 Barosense, Inc. Endoscopic stapling devices and methods
US7721932B2 (en) 2008-03-18 2010-05-25 Barosense, Inc. Endoscopic stapling devices and methods
US8864008B2 (en) 2008-03-18 2014-10-21 Boston Scientific Scimed, Inc. Endoscopic stapling devices and methods
US20090236396A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US20090259235A1 (en) * 2008-04-11 2009-10-15 Genevieve Doucet Surgical fastener for attaching a hernia prosthesis
US8388693B2 (en) * 2008-04-11 2013-03-05 Sofradim Production Surgical fastener for attaching a hernia prosthesis
AU2009239395B2 (en) * 2008-04-23 2013-08-22 Cook Medical Technologies Llc Tacking device
US20090270912A1 (en) * 2008-04-23 2009-10-29 Wilson-Cook Medical Inc. Tacking device
WO2009132111A1 (en) * 2008-04-23 2009-10-29 Wilson-Cook Medical Inc. Tacking device
US10390833B2 (en) 2008-05-12 2019-08-27 Boston Scientific Scimed, Inc. Tissue anchor for securing tissue layers
US10076330B2 (en) 2008-05-12 2018-09-18 Xlumena, Inc. Tissue anchor for securing tissue layers
US8900250B2 (en) 2008-08-19 2014-12-02 Cook Medical Technologies, LLC Apparatus and methods for removing lymph nodes or anchoring into tissue during a translumenal procedure
WO2010022060A1 (en) * 2008-08-19 2010-02-25 Wilson-Cook Medical Inc. Apparatus for removing lymph nodes or anchoring into tissue during a translumenal procedure
US20100049208A1 (en) * 2008-08-19 2010-02-25 Wilson-Cook Medical Inc. Apparatus and methods for removing lymph nodes or anchoring into tissue during a translumenal procedure
WO2010030778A1 (en) * 2008-09-11 2010-03-18 Wilson-Cook Medical Inc. Methods for achieving serosa-to-serosa closure of a bodily opening using one or more tacking devices
US8192461B2 (en) 2008-09-11 2012-06-05 Cook Medical Technologies Llc Methods for facilitating closure of a bodily opening using one or more tacking devices
US20100069955A1 (en) * 2008-09-11 2010-03-18 Wilson-Cook Medical Inc. Methods for facilitating closure of a bodily opening using one or more tacking devices
US11123071B2 (en) 2008-09-19 2021-09-21 Cilag Gmbh International Staple cartridge for us with a surgical instrument
US10258336B2 (en) 2008-09-19 2019-04-16 Ethicon Llc Stapling system configured to produce different formed staple heights
US11517304B2 (en) 2008-09-23 2022-12-06 Cilag Gmbh International Motor-driven surgical cutting instrument
US10045778B2 (en) 2008-09-23 2018-08-14 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US11045189B2 (en) 2008-09-23 2021-06-29 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US10105136B2 (en) 2008-09-23 2018-10-23 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US10420549B2 (en) 2008-09-23 2019-09-24 Ethicon Llc Motorized surgical instrument
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US9028519B2 (en) 2008-09-23 2015-05-12 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US10898184B2 (en) 2008-09-23 2021-01-26 Ethicon Llc Motor-driven surgical cutting instrument
US9005230B2 (en) 2008-09-23 2015-04-14 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US11871923B2 (en) 2008-09-23 2024-01-16 Cilag Gmbh International Motorized surgical instrument
US10765425B2 (en) 2008-09-23 2020-09-08 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US11406380B2 (en) 2008-09-23 2022-08-09 Cilag Gmbh International Motorized surgical instrument
US10238389B2 (en) 2008-09-23 2019-03-26 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US11684361B2 (en) 2008-09-23 2023-06-27 Cilag Gmbh International Motor-driven surgical cutting instrument
US11617576B2 (en) 2008-09-23 2023-04-04 Cilag Gmbh International Motor-driven surgical cutting instrument
US9655614B2 (en) 2008-09-23 2017-05-23 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument with an end effector
US10456133B2 (en) 2008-09-23 2019-10-29 Ethicon Llc Motorized surgical instrument
US11617575B2 (en) 2008-09-23 2023-04-04 Cilag Gmbh International Motor-driven surgical cutting instrument
US10485537B2 (en) 2008-09-23 2019-11-26 Ethicon Llc Motorized surgical instrument
US9386983B2 (en) 2008-09-23 2016-07-12 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument
US9549732B2 (en) 2008-09-23 2017-01-24 Ethicon Endo-Surgery, Llc Motor-driven surgical cutting instrument
US10130361B2 (en) 2008-09-23 2018-11-20 Ethicon Llc Robotically-controller motorized surgical tool with an end effector
US9050083B2 (en) 2008-09-23 2015-06-09 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US10736628B2 (en) 2008-09-23 2020-08-11 Ethicon Llc Motor-driven surgical cutting instrument
US10980535B2 (en) 2008-09-23 2021-04-20 Ethicon Llc Motorized surgical instrument with an end effector
US11812954B2 (en) 2008-09-23 2023-11-14 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US8602287B2 (en) 2008-09-23 2013-12-10 Ethicon Endo-Surgery, Inc. Motor driven surgical cutting instrument
US11103241B2 (en) 2008-09-23 2021-08-31 Cilag Gmbh International Motor-driven surgical cutting instrument
US8602288B2 (en) 2008-09-23 2013-12-10 Ethicon Endo-Surgery. Inc. Robotically-controlled motorized surgical end effector system with rotary actuated closure systems having variable actuation speeds
US9370364B2 (en) 2008-10-10 2016-06-21 Ethicon Endo-Surgery, Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US10932778B2 (en) 2008-10-10 2021-03-02 Ethicon Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US10149683B2 (en) 2008-10-10 2018-12-11 Ethicon Llc Powered surgical cutting and stapling apparatus with manually retractable firing system
US11583279B2 (en) 2008-10-10 2023-02-21 Cilag Gmbh International Powered surgical cutting and stapling apparatus with manually retractable firing system
US8608045B2 (en) 2008-10-10 2013-12-17 Ethicon Endo-Sugery, Inc. Powered surgical cutting and stapling apparatus with manually retractable firing system
US11730477B2 (en) 2008-10-10 2023-08-22 Cilag Gmbh International Powered surgical system with manually retractable firing system
US20100089970A1 (en) * 2008-10-10 2010-04-15 Ethicon Endo-Surgery, Inc. Powered surgical cutting and stapling apparatus with manually retractable firing system
US11793521B2 (en) 2008-10-10 2023-10-24 Cilag Gmbh International Powered surgical cutting and stapling apparatus with manually retractable firing system
US8888811B2 (en) 2008-10-20 2014-11-18 Covidien Lp Device and method for attaching an implant to biological tissue
US11202627B2 (en) 2008-11-10 2021-12-21 Boston Scientific Scimed, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US20100116867A1 (en) * 2008-11-10 2010-05-13 Balbierz Daniel J Multi-fire stapling systems and methods for delivering arrays of staples
US10368862B2 (en) 2008-11-10 2019-08-06 Boston Scientific Scimed, Inc. Multi-fire stapling methods
US7934631B2 (en) 2008-11-10 2011-05-03 Barosense, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US9451956B2 (en) 2008-11-10 2016-09-27 Boston Scientific Scimed, Inc. Multi-fire stapling systems
US8747421B2 (en) 2008-11-10 2014-06-10 Boston Scientific Scimed, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US20100121370A1 (en) * 2008-11-11 2010-05-13 Aga Medical Corporation Asymmetrical medical devices for treating a target site and associated method
US8940015B2 (en) * 2008-11-11 2015-01-27 Aga Medical Corporation Asymmetrical medical devices for treating a target site and associated method
US8500760B2 (en) 2008-12-09 2013-08-06 Cook Medical Technologies Llc Retractable tacking device
US20100145362A1 (en) * 2008-12-09 2010-06-10 Wilson-Cook Medical Inc. Apparatus and methods for controlled release of tacking devices
US8491610B2 (en) 2008-12-19 2013-07-23 Cook Medical Technologies Llc Clip devices and methods of delivery and deployment
US20100160931A1 (en) * 2008-12-19 2010-06-24 Wilson-Cook Medical Inc. Variable thickness tacking devices and methods of delivery and deployment
US20100160935A1 (en) * 2008-12-19 2010-06-24 Wilson-Cook Medical Inc. Clip devices and methods of delivery and deployment
US8414577B2 (en) 2009-02-05 2013-04-09 Ethicon Endo-Surgery, Inc. Surgical instruments and components for use in sterile environments
US10758233B2 (en) 2009-02-05 2020-09-01 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US11129615B2 (en) 2009-02-05 2021-09-28 Cilag Gmbh International Surgical stapling system
US8397971B2 (en) 2009-02-05 2013-03-19 Ethicon Endo-Surgery, Inc. Sterilizable surgical instrument
US9486214B2 (en) 2009-02-06 2016-11-08 Ethicon Endo-Surgery, Llc Motor driven surgical fastener device with switching system configured to prevent firing initiation until activated
US9393015B2 (en) 2009-02-06 2016-07-19 Ethicon Endo-Surgery, Llc Motor driven surgical fastener device with cutting member reversing mechanism
US20140031631A1 (en) * 2009-02-06 2014-01-30 Gregory W. HALL Method and Apparatus for Inducing Therapeutic Hypothermia
US10420550B2 (en) 2009-02-06 2019-09-24 Ethicon Llc Motor driven surgical fastener device with switching system configured to prevent firing initiation until activated
US8734473B2 (en) 2009-02-18 2014-05-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US10433838B2 (en) 2009-03-18 2019-10-08 Endogastric Solutions, Inc. Methods and devices for forming a tissue fold
US10321910B2 (en) 2009-04-21 2019-06-18 Boston Scientific Scimed, Inc. Apparatus and method for deploying stent across adjacent tissue layers
US20100276469A1 (en) * 2009-05-01 2010-11-04 Barosense, Inc. Plication tagging device and method
US20100280529A1 (en) * 2009-05-04 2010-11-04 Barosense, Inc. Endoscopic implant system and method
US8961539B2 (en) 2009-05-04 2015-02-24 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US20100305591A1 (en) * 2009-05-28 2010-12-02 Wilson-Cook Medical Inc. Tacking device and methods of deployment
US9345476B2 (en) 2009-05-28 2016-05-24 Cook Medical Technologies Llc Tacking device and methods of deployment
WO2010138579A1 (en) * 2009-05-28 2010-12-02 Wilson-Cook Medical Inc. Tacking device and methods of deployment
US9888926B2 (en) 2009-05-29 2018-02-13 Boston Scientific Scimed, Inc. Apparatus and method for deploying stent across adjacent tissue layers
US11596391B2 (en) 2009-06-22 2023-03-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US11589853B2 (en) 2009-06-22 2023-02-28 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10806437B2 (en) 2009-06-22 2020-10-20 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10792025B2 (en) 2009-06-22 2020-10-06 W. L. Gore & Associates, Inc. Sealing device and delivery system
US11564672B2 (en) 2009-06-22 2023-01-31 W. L. Gore & Associates, Inc. Sealing device and delivery system
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device
US10751076B2 (en) 2009-12-24 2020-08-25 Ethicon Llc Motor-driven surgical cutting instrument with electric actuator directional control assembly
US11291449B2 (en) 2009-12-24 2022-04-05 Cilag Gmbh International Surgical cutting instrument that analyzes tissue thickness
US20160270785A1 (en) * 2010-05-21 2016-09-22 Boston Scientific Scimed, Inc. Tissue-acquisition and fastening devices and methods
US9439643B2 (en) 2010-06-09 2016-09-13 C.R. Bard, Inc. Instruments for delivering transfascial sutures, transfascial suture assemblies, and methods of transfascial suturing
US10492777B2 (en) 2010-06-09 2019-12-03 C.R. Bard, Inc. Instruments for delivering transfascial sutures, transfascial suture assemblies, and methods of transfascial suturing
US8790356B2 (en) 2010-06-09 2014-07-29 C.R. Bard, Inc. Instruments for delivering transfascial sutures, transfascial suture assemblies, and methods of transfascial suturing
US11478247B2 (en) 2010-07-30 2022-10-25 Cilag Gmbh International Tissue acquisition arrangements and methods for surgical stapling devices
US8789741B2 (en) 2010-09-24 2014-07-29 Ethicon Endo-Surgery, Inc. Surgical instrument with trigger assembly for generating multiple actuation motions
US9566061B2 (en) 2010-09-30 2017-02-14 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a releasably attached tissue thickness compensator
US8763877B2 (en) 2010-09-30 2014-07-01 Ethicon Endo-Surgery, Inc. Surgical instruments with reconfigurable shaft segments
US8814024B2 (en) 2010-09-30 2014-08-26 Ethicon Endo-Surgery, Inc. Fastener system comprising a plurality of connected retention matrix elements
US9033203B2 (en) 2010-09-30 2015-05-19 Ethicon Endo-Surgery, Inc. Fastening instrument for deploying a fastener system comprising a retention matrix
US10194910B2 (en) 2010-09-30 2019-02-05 Ethicon Llc Stapling assemblies comprising a layer
US9883861B2 (en) 2010-09-30 2018-02-06 Ethicon Llc Retainer assembly including a tissue thickness compensator
US8840003B2 (en) 2010-09-30 2014-09-23 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with compact articulation control arrangement
US8752699B2 (en) 2010-09-30 2014-06-17 Ethicon Endo-Surgery, Inc. Implantable fastener cartridge comprising bioabsorbable layers
US9232941B2 (en) 2010-09-30 2016-01-12 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a reservoir
US10182819B2 (en) 2010-09-30 2019-01-22 Ethicon Llc Implantable layer assemblies
US9220500B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising structure to produce a resilient load
US11154296B2 (en) 2010-09-30 2021-10-26 Cilag Gmbh International Anvil layer attached to a proximal end of an end effector
US9220501B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensators
US10898193B2 (en) 2010-09-30 2021-01-26 Ethicon Llc End effector for use with a surgical instrument
US9301755B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Compressible staple cartridge assembly
US10548600B2 (en) 2010-09-30 2020-02-04 Ethicon Llc Multiple thickness implantable layers for surgical stapling devices
US11395651B2 (en) 2010-09-30 2022-07-26 Cilag Gmbh International Adhesive film laminate
US11540824B2 (en) 2010-09-30 2023-01-03 Cilag Gmbh International Tissue thickness compensator
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US9788834B2 (en) 2010-09-30 2017-10-17 Ethicon Llc Layer comprising deployable attachment members
US9332974B2 (en) 2010-09-30 2016-05-10 Ethicon Endo-Surgery, Llc Layered tissue thickness compensator
US9345477B2 (en) 2010-09-30 2016-05-24 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator comprising incorporating a hemostatic agent
US11857187B2 (en) 2010-09-30 2024-01-02 Cilag Gmbh International Tissue thickness compensator comprising controlled release and expansion
US9700317B2 (en) 2010-09-30 2017-07-11 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a releasable tissue thickness compensator
US9358005B2 (en) 2010-09-30 2016-06-07 Ethicon Endo-Surgery, Llc End effector layer including holding features
US10136890B2 (en) 2010-09-30 2018-11-27 Ethicon Llc Staple cartridge comprising a variable thickness compressible portion
US9307965B2 (en) 2010-09-30 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-microbial agent
US9364233B2 (en) 2010-09-30 2016-06-14 Ethicon Endo-Surgery, Llc Tissue thickness compensators for circular surgical staplers
US9272406B2 (en) 2010-09-30 2016-03-01 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a cutting member for releasing a tissue thickness compensator
US9795383B2 (en) 2010-09-30 2017-10-24 Ethicon Llc Tissue thickness compensator comprising resilient members
US10987102B2 (en) 2010-09-30 2021-04-27 Ethicon Llc Tissue thickness compensator comprising a plurality of layers
US10888328B2 (en) 2010-09-30 2021-01-12 Ethicon Llc Surgical end effector
US8740037B2 (en) 2010-09-30 2014-06-03 Ethicon Endo-Surgery, Inc. Compressible fastener cartridge
US8740038B2 (en) 2010-09-30 2014-06-03 Ethicon Endo-Surgery, Inc. Staple cartridge comprising a releasable portion
US11559496B2 (en) 2010-09-30 2023-01-24 Cilag Gmbh International Tissue thickness compensator configured to redistribute compressive forces
US9801634B2 (en) 2010-09-30 2017-10-31 Ethicon Llc Tissue thickness compensator for a surgical stapler
US11849952B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US11672536B2 (en) 2010-09-30 2023-06-13 Cilag Gmbh International Layer of material for a surgical end effector
US11850310B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge including an adjunct
US10258330B2 (en) 2010-09-30 2019-04-16 Ethicon Llc End effector including an implantable arrangement
US10258332B2 (en) 2010-09-30 2019-04-16 Ethicon Llc Stapling system comprising an adjunct and a flowable adhesive
US10265072B2 (en) 2010-09-30 2019-04-23 Ethicon Llc Surgical stapling system comprising an end effector including an implantable layer
US9044227B2 (en) 2010-09-30 2015-06-02 Ethicon Endo-Surgery, Inc. Collapsible fastener cartridge
US10265074B2 (en) 2010-09-30 2019-04-23 Ethicon Llc Implantable layers for surgical stapling devices
US9301752B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising a plurality of capsules
US8925782B2 (en) 2010-09-30 2015-01-06 Ethicon Endo-Surgery, Inc. Implantable fastener cartridge comprising multiple layers
US11883025B2 (en) 2010-09-30 2024-01-30 Cilag Gmbh International Tissue thickness compensator comprising a plurality of layers
US10485536B2 (en) 2010-09-30 2019-11-26 Ethicon Llc Tissue stapler having an anti-microbial agent
US9861361B2 (en) 2010-09-30 2018-01-09 Ethicon Llc Releasable tissue thickness compensator and fastener cartridge having the same
US9044228B2 (en) 2010-09-30 2015-06-02 Ethicon Endo-Surgery, Inc. Fastener system comprising a plurality of fastener cartridges
US8864009B2 (en) 2010-09-30 2014-10-21 Ethicon Endo-Surgery, Inc. Tissue thickness compensator for a surgical stapler comprising an adjustable anvil
US9314246B2 (en) 2010-09-30 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent
US10588623B2 (en) 2010-09-30 2020-03-17 Ethicon Llc Adhesive film laminate
US9386988B2 (en) 2010-09-30 2016-07-12 Ethicon End-Surgery, LLC Retainer assembly including a tissue thickness compensator
US9848875B2 (en) 2010-09-30 2017-12-26 Ethicon Llc Anvil layer attached to a proximal end of an end effector
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US11684360B2 (en) 2010-09-30 2023-06-27 Cilag Gmbh International Staple cartridge comprising a variable thickness compressible portion
US10064624B2 (en) 2010-09-30 2018-09-04 Ethicon Llc End effector with implantable layer
US11571215B2 (en) 2010-09-30 2023-02-07 Cilag Gmbh International Layer of material for a surgical end effector
US10149682B2 (en) 2010-09-30 2018-12-11 Ethicon Llc Stapling system including an actuation system
US10463372B2 (en) 2010-09-30 2019-11-05 Ethicon Llc Staple cartridge comprising multiple regions
US9924947B2 (en) 2010-09-30 2018-03-27 Ethicon Llc Staple cartridge comprising a compressible portion
US9615826B2 (en) 2010-09-30 2017-04-11 Ethicon Endo-Surgery, Llc Multiple thickness implantable layers for surgical stapling devices
US9277919B2 (en) 2010-09-30 2016-03-08 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising fibers to produce a resilient load
US8864007B2 (en) 2010-09-30 2014-10-21 Ethicon Endo-Surgery, Inc. Implantable fastener cartridge having a non-uniform arrangement
US9295464B2 (en) 2010-09-30 2016-03-29 Ethicon Endo-Surgery, Inc. Surgical stapler anvil comprising a plurality of forming pockets
US8783542B2 (en) 2010-09-30 2014-07-22 Ethicon Endo-Surgery, Inc. Fasteners supported by a fastener cartridge support
US9113864B2 (en) 2010-09-30 2015-08-25 Ethicon Endo-Surgery, Inc. Surgical cutting and fastening instruments with separate and distinct fastener deployment and tissue cutting systems
US9592053B2 (en) 2010-09-30 2017-03-14 Ethicon Endo-Surgery, Llc Staple cartridge comprising multiple regions
US9592050B2 (en) 2010-09-30 2017-03-14 Ethicon Endo-Surgery, Llc End effector comprising a distal tissue abutment member
US11083452B2 (en) 2010-09-30 2021-08-10 Cilag Gmbh International Staple cartridge including a tissue thickness compensator
US9844372B2 (en) 2010-09-30 2017-12-19 Ethicon Llc Retainer assembly including a tissue thickness compensator
US11812965B2 (en) 2010-09-30 2023-11-14 Cilag Gmbh International Layer of material for a surgical end effector
US9282962B2 (en) 2010-09-30 2016-03-15 Ethicon Endo-Surgery, Llc Adhesive film laminate
US8978956B2 (en) 2010-09-30 2015-03-17 Ethicon Endo-Surgery, Inc. Jaw closure arrangements for surgical instruments
US11602340B2 (en) 2010-09-30 2023-03-14 Cilag Gmbh International Adhesive film laminate
US9808247B2 (en) 2010-09-30 2017-11-07 Ethicon Llc Stapling system comprising implantable layers
US10835251B2 (en) 2010-09-30 2020-11-17 Ethicon Llc Surgical instrument assembly including an end effector configurable in different positions
US9814462B2 (en) 2010-09-30 2017-11-14 Ethicon Llc Assembly for fastening tissue comprising a compressible layer
US10869669B2 (en) 2010-09-30 2020-12-22 Ethicon Llc Surgical instrument assembly
US10743877B2 (en) 2010-09-30 2020-08-18 Ethicon Llc Surgical stapler with floating anvil
US9113865B2 (en) 2010-09-30 2015-08-25 Ethicon Endo-Surgery, Inc. Staple cartridge comprising a layer
US8899463B2 (en) 2010-09-30 2014-12-02 Ethicon Endo-Surgery, Inc. Surgical staple cartridges supporting non-linearly arranged staples and surgical stapling instruments with common staple-forming pockets
US9113862B2 (en) 2010-09-30 2015-08-25 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with a variable staple forming system
US11406377B2 (en) 2010-09-30 2022-08-09 Cilag Gmbh International Adhesive film laminate
US10028743B2 (en) 2010-09-30 2018-07-24 Ethicon Llc Staple cartridge assembly comprising an implantable layer
US8893949B2 (en) 2010-09-30 2014-11-25 Ethicon Endo-Surgery, Inc. Surgical stapler with floating anvil
US9572574B2 (en) 2010-09-30 2017-02-21 Ethicon Endo-Surgery, Llc Tissue thickness compensators comprising therapeutic agents
US8978954B2 (en) 2010-09-30 2015-03-17 Ethicon Endo-Surgery, Inc. Staple cartridge comprising an adjustable distal portion
US10335150B2 (en) 2010-09-30 2019-07-02 Ethicon Llc Staple cartridge comprising an implantable layer
US10123798B2 (en) 2010-09-30 2018-11-13 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US10335148B2 (en) 2010-09-30 2019-07-02 Ethicon Llc Staple cartridge including a tissue thickness compensator for a surgical stapler
US9433419B2 (en) 2010-09-30 2016-09-06 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a plurality of layers
US8777004B2 (en) 2010-09-30 2014-07-15 Ethicon Endo-Surgery, Inc. Compressible staple cartridge comprising alignment members
US9839420B2 (en) 2010-09-30 2017-12-12 Ethicon Llc Tissue thickness compensator comprising at least one medicament
US9833236B2 (en) 2010-09-30 2017-12-05 Ethicon Llc Tissue thickness compensator for surgical staplers
US10624861B2 (en) 2010-09-30 2020-04-21 Ethicon Llc Tissue thickness compensator configured to redistribute compressive forces
US9320518B2 (en) 2010-09-30 2016-04-26 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an oxygen generating agent
US9833238B2 (en) 2010-09-30 2017-12-05 Ethicon Endo-Surgery, Llc Retainer assembly including a tissue thickness compensator
US10213198B2 (en) 2010-09-30 2019-02-26 Ethicon Llc Actuator for releasing a tissue thickness compensator from a fastener cartridge
US9301753B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Expandable tissue thickness compensator
US8529600B2 (en) 2010-09-30 2013-09-10 Ethicon Endo-Surgery, Inc. Fastener system comprising a retention matrix
US10405854B2 (en) 2010-09-30 2019-09-10 Ethicon Llc Surgical stapling cartridge with layer retention features
US10398436B2 (en) 2010-09-30 2019-09-03 Ethicon Llc Staple cartridge comprising staples positioned within a compressible portion thereof
US10363031B2 (en) 2010-09-30 2019-07-30 Ethicon Llc Tissue thickness compensators for surgical staplers
US11737754B2 (en) 2010-09-30 2023-08-29 Cilag Gmbh International Surgical stapler with floating anvil
US9833242B2 (en) 2010-09-30 2017-12-05 Ethicon Endo-Surgery, Llc Tissue thickness compensators
US11911027B2 (en) 2010-09-30 2024-02-27 Cilag Gmbh International Adhesive film laminate
US9480476B2 (en) 2010-09-30 2016-11-01 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising resilient members
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US9826978B2 (en) 2010-09-30 2017-11-28 Ethicon Llc End effectors with same side closure and firing motions
US11583277B2 (en) 2010-09-30 2023-02-21 Cilag Gmbh International Layer of material for a surgical end effector
US10695062B2 (en) 2010-10-01 2020-06-30 Ethicon Llc Surgical instrument including a retractable firing member
US11529142B2 (en) 2010-10-01 2022-12-20 Cilag Gmbh International Surgical instrument having a power control circuit
US10398445B2 (en) 2011-01-11 2019-09-03 Amsel Medical Corporation Method and apparatus for clamping tissue layers and occluding tubular body structures
US10918391B2 (en) 2011-01-11 2021-02-16 Amsel Medical Corporation Method and apparatus for clamping tissue and occluding tubular body lumens
US20120283758A1 (en) * 2011-01-11 2012-11-08 Arnold Miller Method and apparatus for treating varicose veins
US10820895B2 (en) 2011-01-11 2020-11-03 Amsel Medical Corporation Methods and apparatus for fastening and clamping tissue
US20170202551A1 (en) * 2011-01-11 2017-07-20 Arnold Miller Method and Apparatus for Serial Deployment of Multiple Tissue Fasteners
US9241714B2 (en) 2011-04-29 2016-01-26 Ethicon Endo-Surgery, Inc. Tissue thickness compensator and method for making the same
US11504116B2 (en) 2011-04-29 2022-11-22 Cilag Gmbh International Layer of material for a surgical end effector
US9211120B2 (en) 2011-04-29 2015-12-15 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a plurality of medicaments
US10117652B2 (en) 2011-04-29 2018-11-06 Ethicon Llc End effector comprising a tissue thickness compensator and progressively released attachment members
US9351730B2 (en) 2011-04-29 2016-05-31 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising channels
US9271799B2 (en) 2011-05-27 2016-03-01 Ethicon Endo-Surgery, Llc Robotic surgical system with removable motor housing
US11129616B2 (en) 2011-05-27 2021-09-28 Cilag Gmbh International Surgical stapling system
US11266410B2 (en) 2011-05-27 2022-03-08 Cilag Gmbh International Surgical device for use with a robotic system
US10617420B2 (en) 2011-05-27 2020-04-14 Ethicon Llc Surgical system comprising drive systems
US11439470B2 (en) 2011-05-27 2022-09-13 Cilag Gmbh International Robotically-controlled surgical instrument with selectively articulatable end effector
US9775614B2 (en) 2011-05-27 2017-10-03 Ethicon Endo-Surgery, Llc Surgical stapling instruments with rotatable staple deployment arrangements
US10813641B2 (en) 2011-05-27 2020-10-27 Ethicon Llc Robotically-driven surgical instrument
US9072535B2 (en) 2011-05-27 2015-07-07 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with rotatable staple deployment arrangements
US10485546B2 (en) 2011-05-27 2019-11-26 Ethicon Llc Robotically-driven surgical assembly
US10130366B2 (en) 2011-05-27 2018-11-20 Ethicon Llc Automated reloading devices for replacing used end effectors on robotic surgical systems
US10420561B2 (en) 2011-05-27 2019-09-24 Ethicon Llc Robotically-driven surgical instrument
US10004506B2 (en) 2011-05-27 2018-06-26 Ethicon Llc Surgical system
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US10231794B2 (en) 2011-05-27 2019-03-19 Ethicon Llc Surgical stapling instruments with rotatable staple deployment arrangements
US10071452B2 (en) 2011-05-27 2018-09-11 Ethicon Llc Automated end effector component reloading system for use with a robotic system
US11583278B2 (en) 2011-05-27 2023-02-21 Cilag Gmbh International Surgical stapling system having multi-direction articulation
US11612394B2 (en) 2011-05-27 2023-03-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US9913648B2 (en) 2011-05-27 2018-03-13 Ethicon Endo-Surgery, Llc Surgical system
US10426478B2 (en) 2011-05-27 2019-10-01 Ethicon Llc Surgical stapling systems
US10383633B2 (en) 2011-05-27 2019-08-20 Ethicon Llc Robotically-driven surgical assembly
US10980534B2 (en) 2011-05-27 2021-04-20 Ethicon Llc Robotically-controlled motorized surgical instrument with an end effector
US10780539B2 (en) 2011-05-27 2020-09-22 Ethicon Llc Stapling instrument for use with a robotic system
US10524790B2 (en) 2011-05-27 2020-01-07 Ethicon Llc Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US10736634B2 (en) 2011-05-27 2020-08-11 Ethicon Llc Robotically-driven surgical instrument including a drive system
US10335151B2 (en) 2011-05-27 2019-07-02 Ethicon Llc Robotically-driven surgical instrument
US10779945B2 (en) 2011-06-01 2020-09-22 Valcare, Inc. Percutaneous transcatheter repair of heart valves via trans-apical access
US11266389B2 (en) * 2011-07-11 2022-03-08 Tel Hashomer Medical Research Infrastructure And Services Ltd. Body part repositioning apparatus and method
US20140171733A1 (en) * 2011-07-11 2014-06-19 Tel Hashomer Medical Research Infrastructure And Services Ltd. Body part repositioning apparatus and method
US10292689B2 (en) * 2011-07-11 2019-05-21 Tel Hashomer Medical Research Infrastructure And Services Ltd. Body part repositioning apparatus and method
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US10010319B2 (en) 2011-09-09 2018-07-03 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US9572571B2 (en) 2011-09-09 2017-02-21 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US9861360B2 (en) 2011-09-09 2018-01-09 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US9955957B2 (en) 2011-09-09 2018-05-01 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US9055941B2 (en) 2011-09-23 2015-06-16 Ethicon Endo-Surgery, Inc. Staple cartridge including collapsible deck
US9687237B2 (en) 2011-09-23 2017-06-27 Ethicon Endo-Surgery, Llc Staple cartridge including collapsible deck arrangement
US9216019B2 (en) 2011-09-23 2015-12-22 Ethicon Endo-Surgery, Inc. Surgical stapler with stationary staple drivers
US9592054B2 (en) 2011-09-23 2017-03-14 Ethicon Endo-Surgery, Llc Surgical stapler with stationary staple drivers
US9050084B2 (en) 2011-09-23 2015-06-09 Ethicon Endo-Surgery, Inc. Staple cartridge including collapsible deck arrangement
US9826972B2 (en) 2011-10-24 2017-11-28 C.R. Bard, Inc. Instruments for delivering transfascial sutures, transfascial suture assemblies and methods of transfascial suturing
US20130138149A1 (en) * 2011-11-28 2013-05-30 St. Jude Medical Puerto Rico Llc Large bore anchor device
US9492156B2 (en) * 2011-11-28 2016-11-15 St. Jude Medical Puerto Rico Llc Large bore anchor device
US10285677B2 (en) 2011-11-28 2019-05-14 St. Jude Medical Puerto Rico Llc Large bore anchor device
US9044230B2 (en) 2012-02-13 2015-06-02 Ethicon Endo-Surgery, Inc. Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US9730697B2 (en) 2012-02-13 2017-08-15 Ethicon Endo-Surgery, Llc Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US10695063B2 (en) 2012-02-13 2020-06-30 Ethicon Llc Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US11571307B2 (en) 2012-02-29 2023-02-07 Valcare, Inc. Methods, devices, and systems for percutaneously anchoring annuloplasty rings
US11298230B2 (en) 2012-02-29 2022-04-12 Valcare, Inc. Percutaneous annuloplasty system with anterior-posterior adjustment
US10722363B2 (en) 2012-02-29 2020-07-28 Valcare, Inc. Methods, devices, and systems for percutaneously anchoring annuloplasty rings
US9974538B2 (en) 2012-03-28 2018-05-22 Ethicon Llc Staple cartridge comprising a compressible layer
US9414838B2 (en) 2012-03-28 2016-08-16 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprised of a plurality of materials
US10441285B2 (en) 2012-03-28 2019-10-15 Ethicon Llc Tissue thickness compensator comprising tissue ingrowth features
US9198662B2 (en) 2012-03-28 2015-12-01 Ethicon Endo-Surgery, Inc. Tissue thickness compensator having improved visibility
US9204880B2 (en) 2012-03-28 2015-12-08 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising capsules defining a low pressure environment
US11793509B2 (en) 2012-03-28 2023-10-24 Cilag Gmbh International Staple cartridge including an implantable layer
US9314247B2 (en) 2012-03-28 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating a hydrophilic agent
US9517063B2 (en) 2012-03-28 2016-12-13 Ethicon Endo-Surgery, Llc Movable member for use with a tissue thickness compensator
US10667808B2 (en) 2012-03-28 2020-06-02 Ethicon Llc Staple cartridge comprising an absorbable adjunct
US9320523B2 (en) 2012-03-28 2016-04-26 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising tissue ingrowth features
US9307989B2 (en) 2012-03-28 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorportating a hydrophobic agent
US9724098B2 (en) 2012-03-28 2017-08-08 Ethicon Endo-Surgery, Llc Staple cartridge comprising an implantable layer
US11406378B2 (en) 2012-03-28 2022-08-09 Cilag Gmbh International Staple cartridge comprising a compressible tissue thickness compensator
US9918716B2 (en) 2012-03-28 2018-03-20 Ethicon Llc Staple cartridge comprising implantable layers
US9039649B2 (en) 2012-05-31 2015-05-26 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9173759B2 (en) 2012-05-31 2015-11-03 Valentx, Inc. Devices and methods for gastrointestinal bypass
US8956318B2 (en) 2012-05-31 2015-02-17 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9451960B2 (en) 2012-05-31 2016-09-27 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9566181B2 (en) 2012-05-31 2017-02-14 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9681975B2 (en) 2012-05-31 2017-06-20 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9675489B2 (en) 2012-05-31 2017-06-13 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9050168B2 (en) 2012-05-31 2015-06-09 Valentx, Inc. Devices and methods for gastrointestinal bypass
US10959725B2 (en) 2012-06-15 2021-03-30 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
US10064621B2 (en) 2012-06-15 2018-09-04 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US11707273B2 (en) 2012-06-15 2023-07-25 Cilag Gmbh International Articulatable surgical instrument comprising a firing drive
US9561038B2 (en) 2012-06-28 2017-02-07 Ethicon Endo-Surgery, Llc Interchangeable clip applier
US10874391B2 (en) 2012-06-28 2020-12-29 Ethicon Llc Surgical instrument system including replaceable end effectors
US9907620B2 (en) 2012-06-28 2018-03-06 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US11464513B2 (en) 2012-06-28 2022-10-11 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US11241230B2 (en) 2012-06-28 2022-02-08 Cilag Gmbh International Clip applier tool for use with a robotic surgical system
US11197671B2 (en) 2012-06-28 2021-12-14 Cilag Gmbh International Stapling assembly comprising a lockout
US11007004B2 (en) 2012-06-28 2021-05-18 Ethicon Llc Powered multi-axial articulable electrosurgical device with external dissection features
US9226751B2 (en) 2012-06-28 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical instrument system including replaceable end effectors
US9282974B2 (en) 2012-06-28 2016-03-15 Ethicon Endo-Surgery, Llc Empty clip cartridge lockout
US10932775B2 (en) 2012-06-28 2021-03-02 Ethicon Llc Firing system lockout arrangements for surgical instruments
US11510671B2 (en) 2012-06-28 2022-11-29 Cilag Gmbh International Firing system lockout arrangements for surgical instruments
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US11039837B2 (en) 2012-06-28 2021-06-22 Cilag Gmbh International Firing system lockout arrangements for surgical instruments
US11622766B2 (en) 2012-06-28 2023-04-11 Cilag Gmbh International Empty clip cartridge lockout
US9364230B2 (en) 2012-06-28 2016-06-14 Ethicon Endo-Surgery, Llc Surgical stapling instruments with rotary joint assemblies
US11154299B2 (en) 2012-06-28 2021-10-26 Cilag Gmbh International Stapling assembly comprising a firing lockout
US11278284B2 (en) 2012-06-28 2022-03-22 Cilag Gmbh International Rotary drive arrangements for surgical instruments
US10485541B2 (en) 2012-06-28 2019-11-26 Ethicon Llc Robotically powered surgical device with manually-actuatable reversing system
US9125662B2 (en) 2012-06-28 2015-09-08 Ethicon Endo-Surgery, Inc. Multi-axis articulating and rotating surgical tools
US9028494B2 (en) 2012-06-28 2015-05-12 Ethicon Endo-Surgery, Inc. Interchangeable end effector coupling arrangement
US11141156B2 (en) 2012-06-28 2021-10-12 Cilag Gmbh International Surgical stapling assembly comprising flexible output shaft
US11141155B2 (en) 2012-06-28 2021-10-12 Cilag Gmbh International Drive system for surgical tool
US8747238B2 (en) 2012-06-28 2014-06-10 Ethicon Endo-Surgery, Inc. Rotary drive shaft assemblies for surgical instruments with articulatable end effectors
US11058423B2 (en) 2012-06-28 2021-07-13 Cilag Gmbh International Stapling system including first and second closure systems for use with a surgical robot
US9119657B2 (en) 2012-06-28 2015-09-01 Ethicon Endo-Surgery, Inc. Rotary actuatable closure arrangement for surgical end effector
US11534162B2 (en) 2012-06-28 2022-12-27 Cilag GmbH Inlernational Robotically powered surgical device with manually-actuatable reversing system
US10687812B2 (en) 2012-06-28 2020-06-23 Ethicon Llc Surgical instrument system including replaceable end effectors
US11540829B2 (en) 2012-06-28 2023-01-03 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US11602346B2 (en) 2012-06-28 2023-03-14 Cilag Gmbh International Robotically powered surgical device with manually-actuatable reversing system
US9408606B2 (en) 2012-06-28 2016-08-09 Ethicon Endo-Surgery, Llc Robotically powered surgical device with manually-actuatable reversing system
US11109860B2 (en) 2012-06-28 2021-09-07 Cilag Gmbh International Surgical end effectors for use with hand-held and robotically-controlled rotary powered surgical systems
US11857189B2 (en) 2012-06-28 2024-01-02 Cilag Gmbh International Surgical instrument including first and second articulation joints
US10420555B2 (en) 2012-06-28 2019-09-24 Ethicon Llc Hand held rotary powered surgical instruments with end effectors that are articulatable about multiple axes
US10413294B2 (en) 2012-06-28 2019-09-17 Ethicon Llc Shaft assembly arrangements for surgical instruments
US10258333B2 (en) 2012-06-28 2019-04-16 Ethicon Llc Surgical fastening apparatus with a rotary end effector drive shaft for selective engagement with a motorized drive system
US10383630B2 (en) 2012-06-28 2019-08-20 Ethicon Llc Surgical stapling device with rotary driven firing member
US9101385B2 (en) 2012-06-28 2015-08-11 Ethicon Endo-Surgery, Inc. Electrode connections for rotary driven surgical tools
US9649111B2 (en) 2012-06-28 2017-05-16 Ethicon Endo-Surgery, Llc Replaceable clip cartridge for a clip applier
US9204879B2 (en) 2012-06-28 2015-12-08 Ethicon Endo-Surgery, Inc. Flexible drive member
US10639115B2 (en) 2012-06-28 2020-05-05 Ethicon Llc Surgical end effectors having angled tissue-contacting surfaces
US11779420B2 (en) 2012-06-28 2023-10-10 Cilag Gmbh International Robotic surgical attachments having manually-actuated retraction assemblies
US9072536B2 (en) 2012-06-28 2015-07-07 Ethicon Endo-Surgery, Inc. Differential locking arrangements for rotary powered surgical instruments
US11083457B2 (en) 2012-06-28 2021-08-10 Cilag Gmbh International Surgical instrument system including replaceable end effectors
US11806013B2 (en) 2012-06-28 2023-11-07 Cilag Gmbh International Firing system arrangements for surgical instruments
US11202631B2 (en) 2012-06-28 2021-12-21 Cilag Gmbh International Stapling assembly comprising a firing lockout
US10226270B2 (en) 2012-08-10 2019-03-12 W. L. Gore & Associates, Inc. Microanchors for anchoring devices to body tissues
EP2882351A4 (en) * 2012-08-10 2016-08-03 Gore & Ass Microanchors for anchoring devices to body tissues
US11413055B2 (en) 2012-08-10 2022-08-16 W. L. Gore & Associates, Inc. Microanchors for anchoring devices to body tissues
US11373755B2 (en) 2012-08-23 2022-06-28 Cilag Gmbh International Surgical device drive system including a ratchet mechanism
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
US11771408B2 (en) 2013-01-18 2023-10-03 W. L. Gore & Associates, Inc. Sealing device and delivery system
US9386984B2 (en) 2013-02-08 2016-07-12 Ethicon Endo-Surgery, Llc Staple cartridge comprising a releasable cover
US10092292B2 (en) 2013-02-28 2018-10-09 Ethicon Llc Staple forming features for surgical stapling instrument
US9468438B2 (en) 2013-03-01 2016-10-18 Eticon Endo-Surgery, LLC Sensor straightened end effector during removal through trocar
US11529138B2 (en) 2013-03-01 2022-12-20 Cilag Gmbh International Powered surgical instrument including a rotary drive screw
US9782169B2 (en) 2013-03-01 2017-10-10 Ethicon Llc Rotary powered articulation joints for surgical instruments
US11246618B2 (en) 2013-03-01 2022-02-15 Cilag Gmbh International Surgical instrument soft stop
US9554794B2 (en) 2013-03-01 2017-01-31 Ethicon Endo-Surgery, Llc Multiple processor motor control for modular surgical instruments
US10285695B2 (en) 2013-03-01 2019-05-14 Ethicon Llc Articulatable surgical instruments with conductive pathways
US10226249B2 (en) 2013-03-01 2019-03-12 Ethicon Llc Articulatable surgical instruments with conductive pathways for signal communication
US9326767B2 (en) 2013-03-01 2016-05-03 Ethicon Endo-Surgery, Llc Joystick switch assemblies for surgical instruments
US9398911B2 (en) 2013-03-01 2016-07-26 Ethicon Endo-Surgery, Llc Rotary powered surgical instruments with multiple degrees of freedom
US9358003B2 (en) 2013-03-01 2016-06-07 Ethicon Endo-Surgery, Llc Electromechanical surgical device with signal relay arrangement
US10575868B2 (en) 2013-03-01 2020-03-03 Ethicon Llc Surgical instrument with coupler assembly
US9700309B2 (en) 2013-03-01 2017-07-11 Ethicon Llc Articulatable surgical instruments with conductive pathways for signal communication
US9307986B2 (en) 2013-03-01 2016-04-12 Ethicon Endo-Surgery, Llc Surgical instrument soft stop
US9757264B2 (en) 2013-03-13 2017-09-12 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9345481B2 (en) 2013-03-13 2016-05-24 Ethicon Endo-Surgery, Llc Staple cartridge tissue thickness sensor system
US10893867B2 (en) 2013-03-14 2021-01-19 Ethicon Llc Drive train control arrangements for modular surgical instruments
US9808244B2 (en) 2013-03-14 2017-11-07 Ethicon Llc Sensor arrangements for absolute positioning system for surgical instruments
US9883860B2 (en) 2013-03-14 2018-02-06 Ethicon Llc Interchangeable shaft assemblies for use with a surgical instrument
US10238391B2 (en) 2013-03-14 2019-03-26 Ethicon Llc Drive train control arrangements for modular surgical instruments
US9888919B2 (en) 2013-03-14 2018-02-13 Ethicon Llc Method and system for operating a surgical instrument
US9629623B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgery, Llc Drive system lockout arrangements for modular surgical instruments
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
US10470762B2 (en) 2013-03-14 2019-11-12 Ethicon Llc Multi-function motor for a surgical instrument
US9332987B2 (en) 2013-03-14 2016-05-10 Ethicon Endo-Surgery, Llc Control arrangements for a drive member of a surgical instrument
US9351727B2 (en) 2013-03-14 2016-05-31 Ethicon Endo-Surgery, Llc Drive train control arrangements for modular surgical instruments
US9687230B2 (en) 2013-03-14 2017-06-27 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US10617416B2 (en) 2013-03-14 2020-04-14 Ethicon Llc Control systems for surgical instruments
US11266406B2 (en) 2013-03-14 2022-03-08 Cilag Gmbh International Control systems for surgical instruments
US9351726B2 (en) 2013-03-14 2016-05-31 Ethicon Endo-Surgery, Llc Articulation control system for articulatable surgical instruments
US11382749B2 (en) 2013-03-15 2022-07-12 Valcare, Inc. Systems and methods for delivery of annuloplasty rings
US9795384B2 (en) 2013-03-27 2017-10-24 Ethicon Llc Fastener cartridge comprising a tissue thickness compensator and a gap setting element
US9572577B2 (en) 2013-03-27 2017-02-21 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a tissue thickness compensator including openings therein
US9332984B2 (en) 2013-03-27 2016-05-10 Ethicon Endo-Surgery, Llc Fastener cartridge assemblies
US10405857B2 (en) 2013-04-16 2019-09-10 Ethicon Llc Powered linear surgical stapler
US9826976B2 (en) 2013-04-16 2017-11-28 Ethicon Llc Motor driven surgical instruments with lockable dual drive shafts
US9801626B2 (en) 2013-04-16 2017-10-31 Ethicon Llc Modular motor driven surgical instruments with alignment features for aligning rotary drive shafts with surgical end effector shafts
US10702266B2 (en) 2013-04-16 2020-07-07 Ethicon Llc Surgical instrument system
US9649110B2 (en) 2013-04-16 2017-05-16 Ethicon Llc Surgical instrument comprising a closing drive and a firing drive operated from the same rotatable output
US11622763B2 (en) 2013-04-16 2023-04-11 Cilag Gmbh International Stapling assembly comprising a shiftable drive
US10136887B2 (en) 2013-04-16 2018-11-27 Ethicon Llc Drive system decoupling arrangement for a surgical instrument
US10149680B2 (en) 2013-04-16 2018-12-11 Ethicon Llc Surgical instrument comprising a gap setting system
US11633183B2 (en) 2013-04-16 2023-04-25 Cilag International GmbH Stapling assembly comprising a retraction drive
US9814460B2 (en) 2013-04-16 2017-11-14 Ethicon Llc Modular motor driven surgical instruments with status indication arrangements
US11395652B2 (en) 2013-04-16 2022-07-26 Cilag Gmbh International Powered surgical stapler
US11564679B2 (en) 2013-04-16 2023-01-31 Cilag Gmbh International Powered surgical stapler
US11690615B2 (en) 2013-04-16 2023-07-04 Cilag Gmbh International Surgical system including an electric motor and a surgical instrument
US10888318B2 (en) 2013-04-16 2021-01-12 Ethicon Llc Powered surgical stapler
US9844368B2 (en) 2013-04-16 2017-12-19 Ethicon Llc Surgical system comprising first and second drive systems
US9867612B2 (en) 2013-04-16 2018-01-16 Ethicon Llc Powered surgical stapler
US11638581B2 (en) 2013-04-16 2023-05-02 Cilag Gmbh International Powered surgical stapler
US11406381B2 (en) 2013-04-16 2022-08-09 Cilag Gmbh International Powered surgical stapler
US10813751B2 (en) 2013-05-22 2020-10-27 Valcare, Inc. Transcatheter prosthetic valve for mitral or tricuspid valve replacement
US11617647B2 (en) 2013-05-22 2023-04-04 Valcare, Inc. Transcatheter prosthetic valve for mitral or tricuspid valve replacement
US11654017B2 (en) 2013-05-24 2023-05-23 Valcare, Inc. Heart and peripheral vascular valve replacement in conjunction with a support ring
US11654018B2 (en) 2013-05-24 2023-05-23 Valcare, Inc. Heart and peripheral vascular valve replacement in conjunction with a support ring
US9574644B2 (en) 2013-05-30 2017-02-21 Ethicon Endo-Surgery, Llc Power module for use with a surgical instrument
US11806009B2 (en) 2013-06-28 2023-11-07 Valcare, Inc. Device, system, and method to secure an article to a tissue
US20160106420A1 (en) * 2013-06-28 2016-04-21 Valcare, Inc. Device, system, and method to secure an article to a tissue
US11224422B2 (en) 2013-06-28 2022-01-18 Valcare, Inc. Device, system, and method to secure an article to a tissue
US11058417B2 (en) * 2013-06-28 2021-07-13 Valcare, Inc. Device, system, and method to secure an article to a tissue
US11191536B2 (en) 2013-06-28 2021-12-07 Valcare, Inc. Device, system, and method to secure an article to a tissue
US9307997B2 (en) 2013-08-13 2016-04-12 Cook Medical Technologies Llc Double baffle vascular occluder
EP2856950A3 (en) * 2013-08-13 2015-10-07 Cook Medical Technologies LLC Double baffle vascular occluder
US10828032B2 (en) 2013-08-23 2020-11-10 Ethicon Llc End effector detection systems for surgical instruments
US10624634B2 (en) 2013-08-23 2020-04-21 Ethicon Llc Firing trigger lockout arrangements for surgical instruments
US11504119B2 (en) 2013-08-23 2022-11-22 Cilag Gmbh International Surgical instrument including an electronic firing lockout
US11376001B2 (en) 2013-08-23 2022-07-05 Cilag Gmbh International Surgical stapling device with rotary multi-turn retraction mechanism
US10869665B2 (en) 2013-08-23 2020-12-22 Ethicon Llc Surgical instrument system including a control system
US9445813B2 (en) 2013-08-23 2016-09-20 Ethicon Endo-Surgery, Llc Closure indicator systems for surgical instruments
US9510828B2 (en) 2013-08-23 2016-12-06 Ethicon Endo-Surgery, Llc Conductor arrangements for electrically powered surgical instruments with rotatable end effectors
US9808249B2 (en) 2013-08-23 2017-11-07 Ethicon Llc Attachment portions for surgical instrument assemblies
US10898190B2 (en) 2013-08-23 2021-01-26 Ethicon Llc Secondary battery arrangements for powered surgical instruments
US11133106B2 (en) 2013-08-23 2021-09-28 Cilag Gmbh International Surgical instrument assembly comprising a retraction assembly
US11026680B2 (en) 2013-08-23 2021-06-08 Cilag Gmbh International Surgical instrument configured to operate in different states
US11701110B2 (en) 2013-08-23 2023-07-18 Cilag Gmbh International Surgical instrument including a drive assembly movable in a non-motorized mode of operation
US10441281B2 (en) 2013-08-23 2019-10-15 Ethicon Llc surgical instrument including securing and aligning features
US9775609B2 (en) 2013-08-23 2017-10-03 Ethicon Llc Tamper proof circuit for surgical instrument battery pack
US9987006B2 (en) 2013-08-23 2018-06-05 Ethicon Llc Shroud retention arrangement for sterilizable surgical instruments
US10201349B2 (en) 2013-08-23 2019-02-12 Ethicon Llc End effector detection and firing rate modulation systems for surgical instruments
US11109858B2 (en) 2013-08-23 2021-09-07 Cilag Gmbh International Surgical instrument including a display which displays the position of a firing element
US9283054B2 (en) 2013-08-23 2016-03-15 Ethicon Endo-Surgery, Llc Interactive displays
US9700310B2 (en) 2013-08-23 2017-07-11 Ethicon Llc Firing member retraction devices for powered surgical instruments
US11000274B2 (en) 2013-08-23 2021-05-11 Ethicon Llc Powered surgical instrument
US11134940B2 (en) 2013-08-23 2021-10-05 Cilag Gmbh International Surgical instrument including a variable speed firing member
US11389160B2 (en) 2013-08-23 2022-07-19 Cilag Gmbh International Surgical system comprising a display
US9924942B2 (en) 2013-08-23 2018-03-27 Ethicon Llc Motor-powered articulatable surgical instruments
US10918373B2 (en) 2013-08-31 2021-02-16 Edwards Lifesciences Corporation Devices and methods for locating and implanting tissue anchors at mitral valve commissure
EP3060172A4 (en) * 2013-10-23 2017-07-05 LC Therapeutics, Inc. Percutaneous or minimally invasive cardiac valve repair system and methods of using the same
US9585662B2 (en) 2013-12-23 2017-03-07 Ethicon Endo-Surgery, Llc Fastener cartridge comprising an extendable firing member
US11020109B2 (en) 2013-12-23 2021-06-01 Ethicon Llc Surgical stapling assembly for use with a powered surgical interface
US9724092B2 (en) 2013-12-23 2017-08-08 Ethicon Llc Modular surgical instruments
US10588624B2 (en) 2013-12-23 2020-03-17 Ethicon Llc Surgical staples, staple cartridges and surgical end effectors
US11896223B2 (en) 2013-12-23 2024-02-13 Cilag Gmbh International Surgical cutting and stapling instruments with independent jaw control features
US11583273B2 (en) 2013-12-23 2023-02-21 Cilag Gmbh International Surgical stapling system including a firing beam extending through an articulation region
US11364028B2 (en) 2013-12-23 2022-06-21 Cilag Gmbh International Modular surgical system
US11759201B2 (en) 2013-12-23 2023-09-19 Cilag Gmbh International Surgical stapling system comprising an end effector including an anvil with an anvil cap
US11246587B2 (en) 2013-12-23 2022-02-15 Cilag Gmbh International Surgical cutting and stapling instruments
US11123065B2 (en) 2013-12-23 2021-09-21 Cilag Gmbh International Surgical cutting and stapling instruments with independent jaw control features
US9839428B2 (en) 2013-12-23 2017-12-12 Ethicon Llc Surgical cutting and stapling instruments with independent jaw control features
US9763662B2 (en) 2013-12-23 2017-09-19 Ethicon Llc Fastener cartridge comprising a firing member configured to directly engage and eject fasteners from the fastener cartridge
US9968354B2 (en) 2013-12-23 2018-05-15 Ethicon Llc Surgical staples and methods for making the same
US10925599B2 (en) 2013-12-23 2021-02-23 Ethicon Llc Modular surgical instruments
US9681870B2 (en) 2013-12-23 2017-06-20 Ethicon Llc Articulatable surgical instruments with separate and distinct closing and firing systems
US11026677B2 (en) 2013-12-23 2021-06-08 Cilag Gmbh International Surgical stapling assembly
US10265065B2 (en) 2013-12-23 2019-04-23 Ethicon Llc Surgical staples and staple cartridges
US9642620B2 (en) 2013-12-23 2017-05-09 Ethicon Endo-Surgery, Llc Surgical cutting and stapling instruments with articulatable end effectors
US11779327B2 (en) 2013-12-23 2023-10-10 Cilag Gmbh International Surgical stapling system including a push bar
US9549735B2 (en) 2013-12-23 2017-01-24 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a firing member including fastener transfer surfaces
US11020115B2 (en) 2014-02-12 2021-06-01 Cilag Gmbh International Deliverable surgical instrument
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
US9757124B2 (en) 2014-02-24 2017-09-12 Ethicon Llc Implantable layer assemblies
US9884456B2 (en) 2014-02-24 2018-02-06 Ethicon Llc Implantable layers and methods for altering one or more properties of implantable layers for use with fastening instruments
US9693777B2 (en) 2014-02-24 2017-07-04 Ethicon Llc Implantable layers comprising a pressed region
US10426481B2 (en) 2014-02-24 2019-10-01 Ethicon Llc Implantable layer assemblies
US9839422B2 (en) 2014-02-24 2017-12-12 Ethicon Llc Implantable layers and methods for altering implantable layers for use with surgical fastening instruments
US9775608B2 (en) 2014-02-24 2017-10-03 Ethicon Llc Fastening system comprising a firing member lockout
US9839423B2 (en) 2014-02-24 2017-12-12 Ethicon Llc Implantable layers and methods for modifying the shape of the implantable layers for use with a surgical fastening instrument
WO2015143366A1 (en) 2014-03-21 2015-09-24 Boston Scientific Scimed, Inc. Devices and methods for lumen occlusion
US10588626B2 (en) 2014-03-26 2020-03-17 Ethicon Llc Surgical instrument displaying subsequent step of use
US9733663B2 (en) 2014-03-26 2017-08-15 Ethicon Llc Power management through segmented circuit and variable voltage protection
US10004497B2 (en) 2014-03-26 2018-06-26 Ethicon Llc Interface systems for use with surgical instruments
US10863981B2 (en) 2014-03-26 2020-12-15 Ethicon Llc Interface systems for use with surgical instruments
US9804618B2 (en) 2014-03-26 2017-10-31 Ethicon Llc Systems and methods for controlling a segmented circuit
US10013049B2 (en) 2014-03-26 2018-07-03 Ethicon Llc Power management through sleep options of segmented circuit and wake up control
US10028761B2 (en) 2014-03-26 2018-07-24 Ethicon Llc Feedback algorithms for manual bailout systems for surgical instruments
US11497488B2 (en) 2014-03-26 2022-11-15 Cilag Gmbh International Systems and methods for controlling a segmented circuit
US9690362B2 (en) 2014-03-26 2017-06-27 Ethicon Llc Surgical instrument control circuit having a safety processor
US11259799B2 (en) 2014-03-26 2022-03-01 Cilag Gmbh International Interface systems for use with surgical instruments
US9913642B2 (en) 2014-03-26 2018-03-13 Ethicon Llc Surgical instrument comprising a sensor system
US9750499B2 (en) 2014-03-26 2017-09-05 Ethicon Llc Surgical stapling instrument system
US10117653B2 (en) 2014-03-26 2018-11-06 Ethicon Llc Systems and methods for controlling a segmented circuit
US9820738B2 (en) 2014-03-26 2017-11-21 Ethicon Llc Surgical instrument comprising interactive systems
US10898185B2 (en) 2014-03-26 2021-01-26 Ethicon Llc Surgical instrument power management through sleep and wake up control
US10136889B2 (en) 2014-03-26 2018-11-27 Ethicon Llc Systems and methods for controlling a segmented circuit
US9743929B2 (en) 2014-03-26 2017-08-29 Ethicon Llc Modular powered surgical instrument with detachable shaft assemblies
US9826977B2 (en) 2014-03-26 2017-11-28 Ethicon Llc Sterilization verification circuit
US10201364B2 (en) 2014-03-26 2019-02-12 Ethicon Llc Surgical instrument comprising a rotatable shaft
US9730695B2 (en) 2014-03-26 2017-08-15 Ethicon Endo-Surgery, Llc Power management through segmented circuit
US11298134B2 (en) 2014-04-16 2022-04-12 Cilag Gmbh International Fastener cartridge comprising non-uniform fasteners
US11883026B2 (en) 2014-04-16 2024-01-30 Cilag Gmbh International Fastener cartridge assemblies and staple retainer cover arrangements
US10010324B2 (en) 2014-04-16 2018-07-03 Ethicon Llc Fastener cartridge compromising fastener cavities including fastener control features
US10470768B2 (en) 2014-04-16 2019-11-12 Ethicon Llc Fastener cartridge including a layer attached thereto
US9833241B2 (en) 2014-04-16 2017-12-05 Ethicon Llc Surgical fastener cartridges with driver stabilizing arrangements
US11382625B2 (en) 2014-04-16 2022-07-12 Cilag Gmbh International Fastener cartridge comprising non-uniform fasteners
US11185330B2 (en) 2014-04-16 2021-11-30 Cilag Gmbh International Fastener cartridge assemblies and staple retainer cover arrangements
US10327776B2 (en) 2014-04-16 2019-06-25 Ethicon Llc Surgical stapling buttresses and adjunct materials
US11517315B2 (en) 2014-04-16 2022-12-06 Cilag Gmbh International Fastener cartridges including extensions having different configurations
US11717294B2 (en) 2014-04-16 2023-08-08 Cilag Gmbh International End effector arrangements comprising indicators
US9844369B2 (en) 2014-04-16 2017-12-19 Ethicon Llc Surgical end effectors with firing element monitoring arrangements
US10542988B2 (en) 2014-04-16 2020-01-28 Ethicon Llc End effector comprising an anvil including projections extending therefrom
US11266409B2 (en) 2014-04-16 2022-03-08 Cilag Gmbh International Fastener cartridge comprising a sled including longitudinally-staggered ramps
US11596406B2 (en) 2014-04-16 2023-03-07 Cilag Gmbh International Fastener cartridges including extensions having different configurations
US10299792B2 (en) 2014-04-16 2019-05-28 Ethicon Llc Fastener cartridge comprising non-uniform fasteners
US9877721B2 (en) 2014-04-16 2018-01-30 Ethicon Llc Fastener cartridge comprising tissue control features
US11382627B2 (en) 2014-04-16 2022-07-12 Cilag Gmbh International Surgical stapling assembly comprising a firing member including a lateral extension
US10561422B2 (en) 2014-04-16 2020-02-18 Ethicon Llc Fastener cartridge comprising deployable tissue engaging members
US10368853B2 (en) 2014-06-06 2019-08-06 W. L. Gore & Associates, Inc. Sealing device and delivery system
US11298116B2 (en) 2014-06-06 2022-04-12 W. L. Gore & Associates, Inc. Sealing device and delivery system
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10045781B2 (en) 2014-06-13 2018-08-14 Ethicon Llc Closure lockout systems for surgical instruments
US10135242B2 (en) 2014-09-05 2018-11-20 Ethicon Llc Smart cartridge wake up operation and data retention
US9724094B2 (en) 2014-09-05 2017-08-08 Ethicon Llc Adjunct with integrated sensors to quantify tissue compression
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US11717297B2 (en) 2014-09-05 2023-08-08 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11071545B2 (en) 2014-09-05 2021-07-27 Cilag Gmbh International Smart cartridge wake up operation and data retention
US11406386B2 (en) 2014-09-05 2022-08-09 Cilag Gmbh International End effector including magnetic and impedance sensors
US11076854B2 (en) 2014-09-05 2021-08-03 Cilag Gmbh International Smart cartridge wake up operation and data retention
US10905423B2 (en) 2014-09-05 2021-02-02 Ethicon Llc Smart cartridge wake up operation and data retention
US11653918B2 (en) 2014-09-05 2023-05-23 Cilag Gmbh International Local display of tissue parameter stabilization
US10111679B2 (en) 2014-09-05 2018-10-30 Ethicon Llc Circuitry and sensors for powered medical device
US9757128B2 (en) 2014-09-05 2017-09-12 Ethicon Llc Multiple sensors with one sensor affecting a second sensor's output or interpretation
US11389162B2 (en) 2014-09-05 2022-07-19 Cilag Gmbh International Smart cartridge wake up operation and data retention
US10016199B2 (en) 2014-09-05 2018-07-10 Ethicon Llc Polarity of hall magnet to identify cartridge type
US9788836B2 (en) 2014-09-05 2017-10-17 Ethicon Llc Multiple motor control for powered medical device
US9737301B2 (en) 2014-09-05 2017-08-22 Ethicon Llc Monitoring device degradation based on component evaluation
US11284898B2 (en) 2014-09-18 2022-03-29 Cilag Gmbh International Surgical instrument including a deployable knife
US10426477B2 (en) 2014-09-26 2019-10-01 Ethicon Llc Staple cartridge assembly including a ramp
US10751053B2 (en) 2014-09-26 2020-08-25 Ethicon Llc Fastener cartridges for applying expandable fastener lines
US11202633B2 (en) 2014-09-26 2021-12-21 Cilag Gmbh International Surgical stapling buttresses and adjunct materials
US10426476B2 (en) 2014-09-26 2019-10-01 Ethicon Llc Circular fastener cartridges for applying radially expandable fastener lines
US10206677B2 (en) 2014-09-26 2019-02-19 Ethicon Llc Surgical staple and driver arrangements for staple cartridges
US10327764B2 (en) 2014-09-26 2019-06-25 Ethicon Llc Method for creating a flexible staple line
US9801627B2 (en) 2014-09-26 2017-10-31 Ethicon Llc Fastener cartridge for creating a flexible staple line
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
US9801628B2 (en) 2014-09-26 2017-10-31 Ethicon Llc Surgical staple and driver arrangements for staple cartridges
US10076325B2 (en) 2014-10-13 2018-09-18 Ethicon Llc Surgical stapling apparatus comprising a tissue stop
US10736630B2 (en) 2014-10-13 2020-08-11 Ethicon Llc Staple cartridge
US10052104B2 (en) 2014-10-16 2018-08-21 Ethicon Llc Staple cartridge comprising a tissue thickness compensator
US10905418B2 (en) 2014-10-16 2021-02-02 Ethicon Llc Staple cartridge comprising a tissue thickness compensator
US11185325B2 (en) 2014-10-16 2021-11-30 Cilag Gmbh International End effector including different tissue gaps
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US11701114B2 (en) 2014-10-16 2023-07-18 Cilag Gmbh International Staple cartridge
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11864760B2 (en) 2014-10-29 2024-01-09 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11241229B2 (en) 2014-10-29 2022-02-08 Cilag Gmbh International Staple cartridges comprising driver arrangements
US11457918B2 (en) 2014-10-29 2022-10-04 Cilag Gmbh International Cartridge assemblies for surgical staplers
US10517594B2 (en) 2014-10-29 2019-12-31 Ethicon Llc Cartridge assemblies for surgical staplers
US11337698B2 (en) 2014-11-06 2022-05-24 Cilag Gmbh International Staple cartridge comprising a releasable adjunct material
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US10617417B2 (en) 2014-11-06 2020-04-14 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US11382628B2 (en) 2014-12-10 2022-07-12 Cilag Gmbh International Articulatable surgical instrument system
US11547403B2 (en) 2014-12-18 2023-01-10 Cilag Gmbh International Surgical instrument having a laminate firing actuator and lateral buckling supports
US11553911B2 (en) 2014-12-18 2023-01-17 Cilag Gmbh International Surgical instrument assembly comprising a flexible articulation system
US10004501B2 (en) 2014-12-18 2018-06-26 Ethicon Llc Surgical instruments with improved closure arrangements
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
US10117649B2 (en) 2014-12-18 2018-11-06 Ethicon Llc Surgical instrument assembly comprising a lockable articulation system
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10188385B2 (en) 2014-12-18 2019-01-29 Ethicon Llc Surgical instrument system comprising lockable systems
US11083453B2 (en) 2014-12-18 2021-08-10 Cilag Gmbh International Surgical stapling system including a flexible firing actuator and lateral buckling supports
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US10743873B2 (en) 2014-12-18 2020-08-18 Ethicon Llc Drive arrangements for articulatable surgical instruments
US9943309B2 (en) 2014-12-18 2018-04-17 Ethicon Llc Surgical instruments with articulatable end effectors and movable firing beam support arrangements
US10695058B2 (en) 2014-12-18 2020-06-30 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10806448B2 (en) 2014-12-18 2020-10-20 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US10245027B2 (en) 2014-12-18 2019-04-02 Ethicon Llc Surgical instrument with an anvil that is selectively movable about a discrete non-movable axis relative to a staple cartridge
US10945728B2 (en) 2014-12-18 2021-03-16 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US11571207B2 (en) 2014-12-18 2023-02-07 Cilag Gmbh International Surgical system including lateral supports for a flexible drive member
US11678877B2 (en) 2014-12-18 2023-06-20 Cilag Gmbh International Surgical instrument including a flexible support configured to support a flexible firing member
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US9968355B2 (en) 2014-12-18 2018-05-15 Ethicon Llc Surgical instruments with articulatable end effectors and improved firing beam support arrangements
US11812958B2 (en) 2014-12-18 2023-11-14 Cilag Gmbh International Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US11399831B2 (en) 2014-12-18 2022-08-02 Cilag Gmbh International Drive arrangements for articulatable surgical instruments
US11547404B2 (en) 2014-12-18 2023-01-10 Cilag Gmbh International Surgical instrument assembly comprising a flexible articulation system
US11517311B2 (en) 2014-12-18 2022-12-06 Cilag Gmbh International Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10245028B2 (en) 2015-02-27 2019-04-02 Ethicon Llc Power adapter for a surgical instrument
US10045779B2 (en) 2015-02-27 2018-08-14 Ethicon Llc Surgical instrument system comprising an inspection station
US10321907B2 (en) 2015-02-27 2019-06-18 Ethicon Llc System for monitoring whether a surgical instrument needs to be serviced
US11744588B2 (en) 2015-02-27 2023-09-05 Cilag Gmbh International Surgical stapling instrument including a removably attachable battery pack
US11324506B2 (en) 2015-02-27 2022-05-10 Cilag Gmbh International Modular stapling assembly
US9993258B2 (en) 2015-02-27 2018-06-12 Ethicon Llc Adaptable surgical instrument handle
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US10226250B2 (en) 2015-02-27 2019-03-12 Ethicon Llc Modular stapling assembly
US9931118B2 (en) 2015-02-27 2018-04-03 Ethicon Endo-Surgery, Llc Reinforced battery for a surgical instrument
US10182816B2 (en) 2015-02-27 2019-01-22 Ethicon Llc Charging system that enables emergency resolutions for charging a battery
US10180463B2 (en) 2015-02-27 2019-01-15 Ethicon Llc Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band
US9895148B2 (en) 2015-03-06 2018-02-20 Ethicon Endo-Surgery, Llc Monitoring speed control and precision incrementing of motor for powered surgical instruments
US11224423B2 (en) 2015-03-06 2022-01-18 Cilag Gmbh International Smart sensors with local signal processing
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
US10045776B2 (en) 2015-03-06 2018-08-14 Ethicon Llc Control techniques and sub-processor contained within modular shaft with select control processing from handle
US11109859B2 (en) 2015-03-06 2021-09-07 Cilag Gmbh International Surgical instrument comprising a lockable battery housing
US11350843B2 (en) 2015-03-06 2022-06-07 Cilag Gmbh International Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10524787B2 (en) 2015-03-06 2020-01-07 Ethicon Llc Powered surgical instrument with parameter-based firing rate
US10531887B2 (en) 2015-03-06 2020-01-14 Ethicon Llc Powered surgical instrument including speed display
US10548504B2 (en) 2015-03-06 2020-02-04 Ethicon Llc Overlaid multi sensor radio frequency (RF) electrode system to measure tissue compression
US9808246B2 (en) 2015-03-06 2017-11-07 Ethicon Endo-Surgery, Llc Method of operating a powered surgical instrument
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US10729432B2 (en) 2015-03-06 2020-08-04 Ethicon Llc Methods for operating a powered surgical instrument
US11826132B2 (en) 2015-03-06 2023-11-28 Cilag Gmbh International Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10772625B2 (en) 2015-03-06 2020-09-15 Ethicon Llc Signal and power communication system positioned on a rotatable shaft
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US10052044B2 (en) 2015-03-06 2018-08-21 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10206605B2 (en) 2015-03-06 2019-02-19 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10966627B2 (en) 2015-03-06 2021-04-06 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US11426160B2 (en) 2015-03-06 2022-08-30 Cilag Gmbh International Smart sensors with local signal processing
US9924961B2 (en) 2015-03-06 2018-03-27 Ethicon Endo-Surgery, Llc Interactive feedback system for powered surgical instruments
US9901342B2 (en) 2015-03-06 2018-02-27 Ethicon Endo-Surgery, Llc Signal and power communication system positioned on a rotatable shaft
US10433844B2 (en) 2015-03-31 2019-10-08 Ethicon Llc Surgical instrument with selectively disengageable threaded drive systems
US10213201B2 (en) 2015-03-31 2019-02-26 Ethicon Llc Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw
US10390825B2 (en) 2015-03-31 2019-08-27 Ethicon Llc Surgical instrument with progressive rotary drive systems
US10052102B2 (en) 2015-06-18 2018-08-21 Ethicon Llc Surgical end effectors with dual cam actuated jaw closing features
US10687805B2 (en) * 2015-08-11 2020-06-23 Amsel Medical Corporation Apparatus and methods for clamping tissue layers and occluding hollow vessels
US20180042607A1 (en) * 2015-08-11 2018-02-15 Amsel Medical Corporation Apparatus and Methods for Clamping Tissue Layers and Occluding Hollow Vessels
US10617418B2 (en) 2015-08-17 2020-04-14 Ethicon Llc Implantable layers for a surgical instrument
US11058425B2 (en) 2015-08-17 2021-07-13 Ethicon Llc Implantable layers for a surgical instrument
US10835249B2 (en) 2015-08-17 2020-11-17 Ethicon Llc Implantable layers for a surgical instrument
US10357251B2 (en) 2015-08-26 2019-07-23 Ethicon Llc Surgical staples comprising hardness variations for improved fastening of tissue
US11103248B2 (en) 2015-08-26 2021-08-31 Cilag Gmbh International Surgical staples for minimizing staple roll
US10390829B2 (en) 2015-08-26 2019-08-27 Ethicon Llc Staples comprising a cover
US10028744B2 (en) 2015-08-26 2018-07-24 Ethicon Llc Staple cartridge assembly including staple guides
US10470769B2 (en) 2015-08-26 2019-11-12 Ethicon Llc Staple cartridge assembly comprising staple alignment features on a firing member
US10966724B2 (en) 2015-08-26 2021-04-06 Ethicon Llc Surgical staples comprising a guide
US10433845B2 (en) 2015-08-26 2019-10-08 Ethicon Llc Surgical staple strips for permitting varying staple properties and enabling easy cartridge loading
US10213203B2 (en) 2015-08-26 2019-02-26 Ethicon Llc Staple cartridge assembly without a bottom cover
US11051817B2 (en) 2015-08-26 2021-07-06 Cilag Gmbh International Method for forming a staple against an anvil of a surgical stapling instrument
US10098642B2 (en) 2015-08-26 2018-10-16 Ethicon Llc Surgical staples comprising features for improved fastening of tissue
US10166026B2 (en) 2015-08-26 2019-01-01 Ethicon Llc Staple cartridge assembly including features for controlling the rotation of staples when being ejected therefrom
US10980538B2 (en) 2015-08-26 2021-04-20 Ethicon Llc Surgical stapling configurations for curved and circular stapling instruments
US10517599B2 (en) 2015-08-26 2019-12-31 Ethicon Llc Staple cartridge assembly comprising staple cavities for providing better staple guidance
US11058426B2 (en) 2015-08-26 2021-07-13 Cilag Gmbh International Staple cartridge assembly comprising various tissue compression gaps and staple forming gaps
US11510675B2 (en) 2015-08-26 2022-11-29 Cilag Gmbh International Surgical end effector assembly including a connector strip interconnecting a plurality of staples
US10188394B2 (en) 2015-08-26 2019-01-29 Ethicon Llc Staples configured to support an implantable adjunct
US11219456B2 (en) 2015-08-26 2022-01-11 Cilag Gmbh International Surgical staple strips for permitting varying staple properties and enabling easy cartridge loading
US10172619B2 (en) 2015-09-02 2019-01-08 Ethicon Llc Surgical staple driver arrays
US10357252B2 (en) 2015-09-02 2019-07-23 Ethicon Llc Surgical staple configurations with camming surfaces located between portions supporting surgical staples
US11213295B2 (en) 2015-09-02 2022-01-04 Cilag Gmbh International Surgical staple configurations with camming surfaces located between portions supporting surgical staples
US10238390B2 (en) 2015-09-02 2019-03-26 Ethicon Llc Surgical staple cartridges with driver arrangements for establishing herringbone staple patterns
US11382624B2 (en) 2015-09-02 2022-07-12 Cilag Gmbh International Surgical staple cartridge with improved staple driver configurations
US11589868B2 (en) 2015-09-02 2023-02-28 Cilag Gmbh International Surgical staple configurations with camming surfaces located between portions supporting surgical staples
US10314587B2 (en) 2015-09-02 2019-06-11 Ethicon Llc Surgical staple cartridge with improved staple driver configurations
US10251648B2 (en) 2015-09-02 2019-04-09 Ethicon Llc Surgical staple cartridge staple drivers with central support features
US10076326B2 (en) 2015-09-23 2018-09-18 Ethicon Llc Surgical stapler having current mirror-based motor control
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10863986B2 (en) 2015-09-23 2020-12-15 Ethicon Llc Surgical stapler having downstream current-based motor control
US10085751B2 (en) 2015-09-23 2018-10-02 Ethicon Llc Surgical stapler having temperature-based motor control
US10363036B2 (en) 2015-09-23 2019-07-30 Ethicon Llc Surgical stapler having force-based motor control
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US11849946B2 (en) 2015-09-23 2023-12-26 Cilag Gmbh International Surgical stapler having downstream current-based motor control
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US11490889B2 (en) 2015-09-23 2022-11-08 Cilag Gmbh International Surgical stapler having motor control based on an electrical parameter related to a motor current
US11344299B2 (en) 2015-09-23 2022-05-31 Cilag Gmbh International Surgical stapler having downstream current-based motor control
US11026678B2 (en) 2015-09-23 2021-06-08 Cilag Gmbh International Surgical stapler having motor control based on an electrical parameter related to a motor current
US11076929B2 (en) 2015-09-25 2021-08-03 Cilag Gmbh International Implantable adjunct systems for determining adjunct skew
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US11793522B2 (en) 2015-09-30 2023-10-24 Cilag Gmbh International Staple cartridge assembly including a compressible adjunct
US10736633B2 (en) 2015-09-30 2020-08-11 Ethicon Llc Compressible adjunct with looping members
US10561420B2 (en) 2015-09-30 2020-02-18 Ethicon Llc Tubular absorbable constructs
US10524788B2 (en) 2015-09-30 2020-01-07 Ethicon Llc Compressible adjunct with attachment regions
US10603039B2 (en) 2015-09-30 2020-03-31 Ethicon Llc Progressively releasable implantable adjunct for use with a surgical stapling instrument
US10932779B2 (en) 2015-09-30 2021-03-02 Ethicon Llc Compressible adjunct with crossing spacer fibers
US10285699B2 (en) 2015-09-30 2019-05-14 Ethicon Llc Compressible adjunct
US11890015B2 (en) 2015-09-30 2024-02-06 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US11903586B2 (en) 2015-09-30 2024-02-20 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US11553916B2 (en) 2015-09-30 2023-01-17 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10433846B2 (en) 2015-09-30 2019-10-08 Ethicon Llc Compressible adjunct with crossing spacer fibers
US11690623B2 (en) 2015-09-30 2023-07-04 Cilag Gmbh International Method for applying an implantable layer to a fastener cartridge
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US10307160B2 (en) 2015-09-30 2019-06-04 Ethicon Llc Compressible adjunct assemblies with attachment layers
US10271849B2 (en) 2015-09-30 2019-04-30 Ethicon Llc Woven constructs with interlocked standing fibers
US10478188B2 (en) 2015-09-30 2019-11-19 Ethicon Llc Implantable layer comprising a constricted configuration
US10327777B2 (en) 2015-09-30 2019-06-25 Ethicon Llc Implantable layer comprising plastically deformed fibers
US10172620B2 (en) 2015-09-30 2019-01-08 Ethicon Llc Compressible adjuncts with bonding nodes
US11712244B2 (en) 2015-09-30 2023-08-01 Cilag Gmbh International Implantable layer with spacer fibers
US11129613B2 (en) 2015-12-30 2021-09-28 Cilag Gmbh International Surgical instruments with separable motors and motor control circuits
US11484309B2 (en) 2015-12-30 2022-11-01 Cilag Gmbh International Surgical stapling system comprising a controller configured to cause a motor to reset a firing sequence
US11083454B2 (en) 2015-12-30 2021-08-10 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11759208B2 (en) 2015-12-30 2023-09-19 Cilag Gmbh International Mechanisms for compensating for battery pack failure in powered surgical instruments
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US11058422B2 (en) 2015-12-30 2021-07-13 Cilag Gmbh International Mechanisms for compensating for battery pack failure in powered surgical instruments
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10588625B2 (en) 2016-02-09 2020-03-17 Ethicon Llc Articulatable surgical instruments with off-axis firing beam arrangements
US10413291B2 (en) 2016-02-09 2019-09-17 Ethicon Llc Surgical instrument articulation mechanism with slotted secondary constraint
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US11523823B2 (en) 2016-02-09 2022-12-13 Cilag Gmbh International Surgical instruments with non-symmetrical articulation arrangements
US10470764B2 (en) 2016-02-09 2019-11-12 Ethicon Llc Surgical instruments with closure stroke reduction arrangements
US10653413B2 (en) 2016-02-09 2020-05-19 Ethicon Llc Surgical instruments with an end effector that is highly articulatable relative to an elongate shaft assembly
US10433837B2 (en) 2016-02-09 2019-10-08 Ethicon Llc Surgical instruments with multiple link articulation arrangements
US10245030B2 (en) 2016-02-09 2019-04-02 Ethicon Llc Surgical instruments with tensioning arrangements for cable driven articulation systems
US10245029B2 (en) 2016-02-09 2019-04-02 Ethicon Llc Surgical instrument with articulating and axially translatable end effector
US11730471B2 (en) 2016-02-09 2023-08-22 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US11826045B2 (en) 2016-02-12 2023-11-28 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10258331B2 (en) 2016-02-12 2019-04-16 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11344303B2 (en) 2016-02-12 2022-05-31 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11779336B2 (en) 2016-02-12 2023-10-10 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10448948B2 (en) 2016-02-12 2019-10-22 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11058538B2 (en) 2016-03-10 2021-07-13 Charles Somers Living Trust Synthetic chord for cardiac valve repair applications
US10376263B2 (en) 2016-04-01 2019-08-13 Ethicon Llc Anvil modification members for surgical staplers
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US11317910B2 (en) 2016-04-15 2022-05-03 Cilag Gmbh International Surgical instrument with detection sensors
US11311292B2 (en) 2016-04-15 2022-04-26 Cilag Gmbh International Surgical instrument with detection sensors
US11642125B2 (en) 2016-04-15 2023-05-09 Cilag Gmbh International Robotic surgical system including a user interface and a control circuit
US10492783B2 (en) 2016-04-15 2019-12-03 Ethicon, Llc Surgical instrument with improved stop/start control during a firing motion
US11771454B2 (en) 2016-04-15 2023-10-03 Cilag Gmbh International Stapling assembly including a controller for monitoring a clamping laod
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10405859B2 (en) 2016-04-15 2019-09-10 Ethicon Llc Surgical instrument with adjustable stop/start control during a firing motion
US11026684B2 (en) 2016-04-15 2021-06-08 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11350932B2 (en) 2016-04-15 2022-06-07 Cilag Gmbh International Surgical instrument with improved stop/start control during a firing motion
US11051810B2 (en) 2016-04-15 2021-07-06 Cilag Gmbh International Modular surgical instrument with configurable operating mode
US11191545B2 (en) 2016-04-15 2021-12-07 Cilag Gmbh International Staple formation detection mechanisms
US10828028B2 (en) 2016-04-15 2020-11-10 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US11284891B2 (en) 2016-04-15 2022-03-29 Cilag Gmbh International Surgical instrument with multiple program responses during a firing motion
US11517306B2 (en) 2016-04-15 2022-12-06 Cilag Gmbh International Surgical instrument with detection sensors
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10368867B2 (en) 2016-04-18 2019-08-06 Ethicon Llc Surgical instrument comprising a lockout
US10363037B2 (en) 2016-04-18 2019-07-30 Ethicon Llc Surgical instrument system comprising a magnetic lockout
US11147554B2 (en) 2016-04-18 2021-10-19 Cilag Gmbh International Surgical instrument system comprising a magnetic lockout
US11559303B2 (en) 2016-04-18 2023-01-24 Cilag Gmbh International Cartridge lockout arrangements for rotary powered surgical cutting and stapling instruments
US11350928B2 (en) 2016-04-18 2022-06-07 Cilag Gmbh International Surgical instrument comprising a tissue thickness lockout and speed control system
US11811253B2 (en) 2016-04-18 2023-11-07 Cilag Gmbh International Surgical robotic system with fault state detection configurations based on motor current draw
US10478181B2 (en) 2016-04-18 2019-11-19 Ethicon Llc Cartridge lockout arrangements for rotary powered surgical cutting and stapling instruments
US10426469B2 (en) 2016-04-18 2019-10-01 Ethicon Llc Surgical instrument comprising a primary firing lockout and a secondary firing lockout
US10433840B2 (en) 2016-04-18 2019-10-08 Ethicon Llc Surgical instrument comprising a replaceable cartridge jaw
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US11076856B2 (en) 2016-05-23 2021-08-03 Mor Research Applications Ltd. Anastomosis device
WO2017203523A1 (en) * 2016-05-23 2017-11-30 Mor Research Applications Ltd. Anastomosis device
USD948043S1 (en) 2016-06-24 2022-04-05 Cilag Gmbh International Surgical fastener
USD896379S1 (en) 2016-06-24 2020-09-15 Ethicon Llc Surgical fastener cartridge
US10893863B2 (en) 2016-06-24 2021-01-19 Ethicon Llc Staple cartridge comprising offset longitudinal staple rows
US10542979B2 (en) 2016-06-24 2020-01-28 Ethicon Llc Stamped staples and staple cartridges using the same
US11000278B2 (en) 2016-06-24 2021-05-11 Ethicon Llc Staple cartridge comprising wire staples and stamped staples
USD826405S1 (en) 2016-06-24 2018-08-21 Ethicon Llc Surgical fastener
US10702270B2 (en) 2016-06-24 2020-07-07 Ethicon Llc Stapling system for use with wire staples and stamped staples
USD894389S1 (en) 2016-06-24 2020-08-25 Ethicon Llc Surgical fastener
USD896380S1 (en) 2016-06-24 2020-09-15 Ethicon Llc Surgical fastener cartridge
USD850617S1 (en) 2016-06-24 2019-06-04 Ethicon Llc Surgical fastener cartridge
US11786246B2 (en) 2016-06-24 2023-10-17 Cilag Gmbh International Stapling system for use with wire staples and stamped staples
US11690619B2 (en) 2016-06-24 2023-07-04 Cilag Gmbh International Staple cartridge comprising staples having different geometries
US10675024B2 (en) 2016-06-24 2020-06-09 Ethicon Llc Staple cartridge comprising overdriven staples
USD847989S1 (en) 2016-06-24 2019-05-07 Ethicon Llc Surgical fastener cartridge
USD822206S1 (en) 2016-06-24 2018-07-03 Ethicon Llc Surgical fastener
US11103349B2 (en) 2016-08-15 2021-08-31 Valcare, Inc. Devices and methods for the treatment of heart valve insufficiencies
US10993715B2 (en) 2016-12-21 2021-05-04 Ethicon Llc Staple cartridge comprising staples with different clamping breadths
US10675025B2 (en) 2016-12-21 2020-06-09 Ethicon Llc Shaft assembly comprising separately actuatable and retractable systems
US10888322B2 (en) 2016-12-21 2021-01-12 Ethicon Llc Surgical instrument comprising a cutting member
US11350935B2 (en) 2016-12-21 2022-06-07 Cilag Gmbh International Surgical tool assemblies with closure stroke reduction features
US10856868B2 (en) 2016-12-21 2020-12-08 Ethicon Llc Firing member pin configurations
US10667811B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Surgical stapling instruments and staple-forming anvils
US10667810B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Closure members with cam surface arrangements for surgical instruments with separate and distinct closure and firing systems
US11350934B2 (en) 2016-12-21 2022-06-07 Cilag Gmbh International Staple forming pocket arrangement to accommodate different types of staples
US11849948B2 (en) 2016-12-21 2023-12-26 Cilag Gmbh International Method for resetting a fuse of a surgical instrument shaft
US11564688B2 (en) 2016-12-21 2023-01-31 Cilag Gmbh International Robotic surgical tool having a retraction mechanism
US11160551B2 (en) 2016-12-21 2021-11-02 Cilag Gmbh International Articulatable surgical stapling instruments
US11160553B2 (en) 2016-12-21 2021-11-02 Cilag Gmbh International Surgical stapling systems
US11766260B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Methods of stapling tissue
US10682138B2 (en) 2016-12-21 2020-06-16 Ethicon Llc Bilaterally asymmetric staple forming pocket pairs
US11369376B2 (en) 2016-12-21 2022-06-28 Cilag Gmbh International Surgical stapling systems
US11766259B2 (en) 2016-12-21 2023-09-26 Cilag Gmbh International Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US10687809B2 (en) 2016-12-21 2020-06-23 Ethicon Llc Surgical staple cartridge with movable camming member configured to disengage firing member lockout features
US11571210B2 (en) 2016-12-21 2023-02-07 Cilag Gmbh International Firing assembly comprising a multiple failed-state fuse
US10835245B2 (en) 2016-12-21 2020-11-17 Ethicon Llc Method for attaching a shaft assembly to a surgical instrument and, alternatively, to a surgical robot
US11179155B2 (en) 2016-12-21 2021-11-23 Cilag Gmbh International Anvil arrangements for surgical staplers
US10835247B2 (en) 2016-12-21 2020-11-17 Ethicon Llc Lockout arrangements for surgical end effectors
US10687810B2 (en) 2016-12-21 2020-06-23 Ethicon Llc Stepped staple cartridge with tissue retention and gap setting features
US10639035B2 (en) 2016-12-21 2020-05-05 Ethicon Llc Surgical stapling instruments and replaceable tool assemblies thereof
US11191539B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Shaft assembly comprising a manually-operable retraction system for use with a motorized surgical instrument system
US10813638B2 (en) 2016-12-21 2020-10-27 Ethicon Llc Surgical end effectors with expandable tissue stop arrangements
US10639034B2 (en) 2016-12-21 2020-05-05 Ethicon Llc Surgical instruments with lockout arrangements for preventing firing system actuation unless an unspent staple cartridge is present
US11191540B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Protective cover arrangements for a joint interface between a movable jaw and actuator shaft of a surgical instrument
US11191543B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Assembly comprising a lock
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
US10426471B2 (en) 2016-12-21 2019-10-01 Ethicon Llc Surgical instrument with multiple failure response modes
US11000276B2 (en) 2016-12-21 2021-05-11 Ethicon Llc Stepped staple cartridge with asymmetrical staples
US10675026B2 (en) 2016-12-21 2020-06-09 Ethicon Llc Methods of stapling tissue
US10588632B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical end effectors and firing members thereof
US10624635B2 (en) 2016-12-21 2020-04-21 Ethicon Llc Firing members with non-parallel jaw engagement features for surgical end effectors
US10779823B2 (en) 2016-12-21 2020-09-22 Ethicon Llc Firing member pin angle
US11701115B2 (en) 2016-12-21 2023-07-18 Cilag Gmbh International Methods of stapling tissue
US10617414B2 (en) 2016-12-21 2020-04-14 Ethicon Llc Closure member arrangements for surgical instruments
US11090048B2 (en) 2016-12-21 2021-08-17 Cilag Gmbh International Method for resetting a fuse of a surgical instrument shaft
US10610224B2 (en) 2016-12-21 2020-04-07 Ethicon Llc Lockout arrangements for surgical end effectors and replaceable tool assemblies
US10667809B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Staple cartridge and staple cartridge channel comprising windows defined therein
US11224428B2 (en) 2016-12-21 2022-01-18 Cilag Gmbh International Surgical stapling systems
US10918385B2 (en) 2016-12-21 2021-02-16 Ethicon Llc Surgical system comprising a firing member rotatable into an articulation state to articulate an end effector of the surgical system
US10448950B2 (en) 2016-12-21 2019-10-22 Ethicon Llc Surgical staplers with independently actuatable closing and firing systems
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US11684367B2 (en) 2016-12-21 2023-06-27 Cilag Gmbh International Stepped assembly having and end-of-life indicator
US10980536B2 (en) 2016-12-21 2021-04-20 Ethicon Llc No-cartridge and spent cartridge lockout arrangements for surgical staplers
US10695055B2 (en) 2016-12-21 2020-06-30 Ethicon Llc Firing assembly comprising a lockout
US10603036B2 (en) 2016-12-21 2020-03-31 Ethicon Llc Articulatable surgical instrument with independent pivotable linkage distal of an articulation lock
US10758230B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument with primary and safety processors
US10485543B2 (en) 2016-12-21 2019-11-26 Ethicon Llc Anvil having a knife slot width
US10758229B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument comprising improved jaw control
US10492785B2 (en) 2016-12-21 2019-12-03 Ethicon Llc Shaft assembly comprising a lockout
US10499914B2 (en) 2016-12-21 2019-12-10 Ethicon Llc Staple forming pocket arrangements
US10973516B2 (en) 2016-12-21 2021-04-13 Ethicon Llc Surgical end effectors and adaptable firing members therefor
US11317913B2 (en) 2016-12-21 2022-05-03 Cilag Gmbh International Lockout arrangements for surgical end effectors and replaceable tool assemblies
US11653917B2 (en) 2016-12-21 2023-05-23 Cilag Gmbh International Surgical stapling systems
US10517596B2 (en) 2016-12-21 2019-12-31 Ethicon Llc Articulatable surgical instruments with articulation stroke amplification features
US10898186B2 (en) 2016-12-21 2021-01-26 Ethicon Llc Staple forming pocket arrangements comprising primary sidewalls and pocket sidewalls
US10517595B2 (en) 2016-12-21 2019-12-31 Ethicon Llc Jaw actuated lock arrangements for preventing advancement of a firing member in a surgical end effector unless an unfired cartridge is installed in the end effector
US10524789B2 (en) 2016-12-21 2020-01-07 Ethicon Llc Laterally actuatable articulation lock arrangements for locking an end effector of a surgical instrument in an articulated configuration
US10959727B2 (en) 2016-12-21 2021-03-30 Ethicon Llc Articulatable surgical end effector with asymmetric shaft arrangement
US10537325B2 (en) 2016-12-21 2020-01-21 Ethicon Llc Staple forming pocket arrangement to accommodate different types of staples
US10537324B2 (en) 2016-12-21 2020-01-21 Ethicon Llc Stepped staple cartridge with asymmetrical staples
US11096689B2 (en) 2016-12-21 2021-08-24 Cilag Gmbh International Shaft assembly comprising a lockout
US10542982B2 (en) 2016-12-21 2020-01-28 Ethicon Llc Shaft assembly comprising first and second articulation lockouts
US10881401B2 (en) 2016-12-21 2021-01-05 Ethicon Llc Staple firing member comprising a missing cartridge and/or spent cartridge lockout
US10568625B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Staple cartridges and arrangements of staples and staple cavities therein
US10568626B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaw opening features for increasing a jaw opening distance
US10736629B2 (en) 2016-12-21 2020-08-11 Ethicon Llc Surgical tool assemblies with clutching arrangements for shifting between closure systems with closure stroke reduction features and articulation and firing systems
US10568624B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaws that are pivotable about a fixed axis and include separate and distinct closure and firing systems
US10582928B2 (en) 2016-12-21 2020-03-10 Ethicon Llc Articulation lock arrangements for locking an end effector in an articulated position in response to actuation of a jaw closure system
US10588630B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical tool assemblies with closure stroke reduction features
US10893864B2 (en) 2016-12-21 2021-01-19 Ethicon Staple cartridges and arrangements of staples and staple cavities therein
US10905422B2 (en) 2016-12-21 2021-02-02 Ethicon Llc Surgical instrument for use with a robotic surgical system
US10945727B2 (en) 2016-12-21 2021-03-16 Ethicon Llc Staple cartridge with deformable driver retention features
US11497499B2 (en) 2016-12-21 2022-11-15 Cilag Gmbh International Articulatable surgical stapling instruments
US10588631B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical instruments with positive jaw opening features
US11576779B2 (en) 2017-03-17 2023-02-14 Valcare, Inc. Mitral or tricuspid repair systems with multi-directional anchors
US11607390B2 (en) 2017-05-17 2023-03-21 Massachusetts Institute Of Technology Self-righting systems and related components and methods
US11207272B2 (en) 2017-05-17 2021-12-28 Massachusetts Institute Of Technology Tissue anchoring articles
US11311489B2 (en) 2017-05-17 2022-04-26 Massachusetts Institute Of Technology Components with high API loading
US11369574B2 (en) 2017-05-17 2022-06-28 Massachusetts Institute Of Technology Self-righting systems and related components and methods
US11179341B2 (en) 2017-05-17 2021-11-23 Massachusetts Institute Of Technology Self-righting articles
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US11541016B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US11712421B2 (en) 2017-05-17 2023-08-01 Massachusetts Institute Of Technology Self-actuating articles
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US11213302B2 (en) 2017-06-20 2022-01-04 Cilag Gmbh International Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
US11672532B2 (en) 2017-06-20 2023-06-13 Cilag Gmbh International Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US11871939B2 (en) 2017-06-20 2024-01-16 Cilag Gmbh International Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10595882B2 (en) 2017-06-20 2020-03-24 Ethicon Llc Methods for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
US10390841B2 (en) 2017-06-20 2019-08-27 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
US10368864B2 (en) 2017-06-20 2019-08-06 Ethicon Llc Systems and methods for controlling displaying motor velocity for a surgical instrument
US11793513B2 (en) 2017-06-20 2023-10-24 Cilag Gmbh International Systems and methods for controlling motor speed according to user input for a surgical instrument
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US11491315B2 (en) 2017-06-20 2022-11-08 Boston Scientific Scimed, Inc. Systems and methods for creating permanent drainage fistula
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US11766258B2 (en) 2017-06-27 2023-09-26 Cilag Gmbh International Surgical anvil arrangements
US11090049B2 (en) 2017-06-27 2021-08-17 Cilag Gmbh International Staple forming pocket arrangements
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US10631859B2 (en) 2017-06-27 2020-04-28 Ethicon Llc Articulation systems for surgical instruments
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US11141154B2 (en) 2017-06-27 2021-10-12 Cilag Gmbh International Surgical end effectors and anvils
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
US11826048B2 (en) 2017-06-28 2023-11-28 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
USD854151S1 (en) 2017-06-28 2019-07-16 Ethicon Llc Surgical instrument shaft
US11642128B2 (en) 2017-06-28 2023-05-09 Cilag Gmbh International Method for articulating a surgical instrument
US10639037B2 (en) 2017-06-28 2020-05-05 Ethicon Llc Surgical instrument with axially movable closure member
US11058424B2 (en) 2017-06-28 2021-07-13 Cilag Gmbh International Surgical instrument comprising an offset articulation joint
USD851762S1 (en) 2017-06-28 2019-06-18 Ethicon Llc Anvil
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
US11529140B2 (en) 2017-06-28 2022-12-20 Cilag Gmbh International Surgical instrument lockout arrangement
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US11020114B2 (en) 2017-06-28 2021-06-01 Cilag Gmbh International Surgical instruments with articulatable end effector with axially shortened articulation joint configurations
US10695057B2 (en) 2017-06-28 2020-06-30 Ethicon Llc Surgical instrument lockout arrangement
US11484310B2 (en) 2017-06-28 2022-11-01 Cilag Gmbh International Surgical instrument comprising a shaft including a closure tube profile
US10211586B2 (en) 2017-06-28 2019-02-19 Ethicon Llc Surgical shaft assemblies with watertight housings
USD869655S1 (en) 2017-06-28 2019-12-10 Ethicon Llc Surgical fastener cartridge
US11389161B2 (en) 2017-06-28 2022-07-19 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US11083455B2 (en) 2017-06-28 2021-08-10 Cilag Gmbh International Surgical instrument comprising an articulation system ratio
US10758232B2 (en) 2017-06-28 2020-09-01 Ethicon Llc Surgical instrument with positive jaw opening features
US11000279B2 (en) 2017-06-28 2021-05-11 Ethicon Llc Surgical instrument comprising an articulation system ratio
US10786253B2 (en) 2017-06-28 2020-09-29 Ethicon Llc Surgical end effectors with improved jaw aperture arrangements
US10779824B2 (en) 2017-06-28 2020-09-22 Ethicon Llc Surgical instrument comprising an articulation system lockable by a closure system
US11696759B2 (en) 2017-06-28 2023-07-11 Cilag Gmbh International Surgical stapling instruments comprising shortened staple cartridge noses
US10588633B2 (en) 2017-06-28 2020-03-17 Ethicon Llc Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing
US11478242B2 (en) 2017-06-28 2022-10-25 Cilag Gmbh International Jaw retainer arrangement for retaining a pivotable surgical instrument jaw in pivotable retaining engagement with a second surgical instrument jaw
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
US11678880B2 (en) 2017-06-28 2023-06-20 Cilag Gmbh International Surgical instrument comprising a shaft including a housing arrangement
US10258418B2 (en) 2017-06-29 2019-04-16 Ethicon Llc System for controlling articulation forces
US11890005B2 (en) 2017-06-29 2024-02-06 Cilag Gmbh International Methods for closed loop velocity control for robotic surgical instrument
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
US10398434B2 (en) 2017-06-29 2019-09-03 Ethicon Llc Closed loop velocity control of closure member for robotic surgical instrument
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
US10729501B2 (en) 2017-09-29 2020-08-04 Ethicon Llc Systems and methods for language selection of a surgical instrument
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
US10796471B2 (en) 2017-09-29 2020-10-06 Ethicon Llc Systems and methods of displaying a knife position for a surgical instrument
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US11478244B2 (en) 2017-10-31 2022-10-25 Cilag Gmbh International Cartridge body design with force reduction based on firing completion
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
US11918209B2 (en) 2017-11-10 2024-03-05 Cilag Gmbh International Torque optimization for surgical instruments
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US11896222B2 (en) 2017-12-15 2024-02-13 Cilag Gmbh International Methods of operating surgical end effectors
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
US11284953B2 (en) 2017-12-19 2022-03-29 Cilag Gmbh International Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US11179151B2 (en) 2017-12-21 2021-11-23 Cilag Gmbh International Surgical instrument comprising a display
US11583274B2 (en) 2017-12-21 2023-02-21 Cilag Gmbh International Self-guiding stapling instrument
US11179152B2 (en) 2017-12-21 2021-11-23 Cilag Gmbh International Surgical instrument comprising a tissue grasping system
US11369368B2 (en) 2017-12-21 2022-06-28 Cilag Gmbh International Surgical instrument comprising synchronized drive systems
US11751867B2 (en) 2017-12-21 2023-09-12 Cilag Gmbh International Surgical instrument comprising sequenced systems
US11576668B2 (en) 2017-12-21 2023-02-14 Cilag Gmbh International Staple instrument comprising a firing path display
US11883019B2 (en) 2017-12-21 2024-01-30 Cilag Gmbh International Stapling instrument comprising a staple feeding system
US11849939B2 (en) 2017-12-21 2023-12-26 Cilag Gmbh International Continuous use self-propelled stapling instrument
US11364027B2 (en) 2017-12-21 2022-06-21 Cilag Gmbh International Surgical instrument comprising speed control
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
US10682134B2 (en) 2017-12-21 2020-06-16 Ethicon Llc Continuous use self-propelled stapling instrument
US11337691B2 (en) 2017-12-21 2022-05-24 Cilag Gmbh International Surgical instrument configured to determine firing path
US10743868B2 (en) 2017-12-21 2020-08-18 Ethicon Llc Surgical instrument comprising a pivotable distal head
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11202903B2 (en) 2018-05-17 2021-12-21 Massachusetts Institute Of Technology Systems for electrical stimulation
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
WO2020072259A1 (en) 2018-10-03 2020-04-09 Absolutions Med, Inc. Abdominal closure method and device variations
EP3836852A4 (en) * 2018-10-03 2022-05-04 Absolutions Med, Inc. Abdominal closure method and device variations
US11534300B2 (en) 2018-12-03 2022-12-27 Valcare, Inc. Stabilizing and adjusting tool for controlling a minimally invasive mitral / tricuspid valve repair system
US11918211B2 (en) 2018-12-28 2024-03-05 Cilag Gmbh International Surgical stapling instrument for use with a robotic system
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11877920B2 (en) 2019-04-10 2024-01-23 Absolutions Med, Inc. Abdominal closure method and device variations for closing ventral hernias and reducing recurrence
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11229437B2 (en) 2019-06-28 2022-01-25 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11744593B2 (en) 2019-06-28 2023-09-05 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11553919B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Method for authenticating the compatibility of a staple cartridge with a surgical instrument
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11241235B2 (en) 2019-06-28 2022-02-08 Cilag Gmbh International Method of using multiple RFID chips with a surgical assembly
US11350938B2 (en) 2019-06-28 2022-06-07 Cilag Gmbh International Surgical instrument comprising an aligned rfid sensor
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11684369B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Method of using multiple RFID chips with a surgical assembly
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11793628B2 (en) 2019-07-15 2023-10-24 Valcare, Inc. Transcatheter bio-prosthesis member and support structure
US11918212B2 (en) 2019-08-12 2024-03-05 Cilag Gmbh International Surgical instrument with selectively disengageable drive systems
US11918213B2 (en) 2019-08-20 2024-03-05 Cilag Gmbh International Surgical stapler including couplers for attaching a shaft to an end effector
US11918220B2 (en) 2019-08-30 2024-03-05 Cilag Gmbh International Tissue thickness compensator comprising tissue ingrowth features
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
US11857182B2 (en) 2020-07-28 2024-01-02 Cilag Gmbh International Surgical instruments with combination function articulation joint arrangements
US11826013B2 (en) 2020-07-28 2023-11-28 Cilag Gmbh International Surgical instruments with firing member closure features
US11638582B2 (en) 2020-07-28 2023-05-02 Cilag Gmbh International Surgical instruments with torsion spine drive arrangements
US11660090B2 (en) 2020-07-28 2023-05-30 Cllag GmbH International Surgical instruments with segmented flexible drive arrangements
US11883024B2 (en) 2020-07-28 2024-01-30 Cilag Gmbh International Method of operating a surgical instrument
US11737748B2 (en) 2020-07-28 2023-08-29 Cilag Gmbh International Surgical instruments with double spherical articulation joints with pivotable links
US11871925B2 (en) 2020-07-28 2024-01-16 Cilag Gmbh International Surgical instruments with dual spherical articulation joint arrangements
US11864756B2 (en) 2020-07-28 2024-01-09 Cilag Gmbh International Surgical instruments with flexible ball chain drive arrangements
US11896229B2 (en) 2020-09-01 2024-02-13 Boston Scientific Scimed, Inc. Grappling systems and methods for lumen apposition or wound defects
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11925349B2 (en) 2021-02-26 2024-03-12 Cilag Gmbh International Adjustment to transfer parameters to improve available power
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11826047B2 (en) 2021-05-28 2023-11-28 Cilag Gmbh International Stapling instrument comprising jaw mounts
US11723662B2 (en) 2021-05-28 2023-08-15 Cilag Gmbh International Stapling instrument comprising an articulation control display
US11918215B2 (en) 2021-09-27 2024-03-05 Cilag Gmbh International Staple cartridge with array of staple pockets
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
US11925354B2 (en) 2021-11-22 2024-03-12 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US11925353B2 (en) 2021-11-22 2024-03-12 Cilag Gmbh International Surgical stapling instrument comprising internal passage between stapling cartridge and elongate channel
WO2023179576A1 (en) * 2022-03-21 2023-09-28 南微医学科技股份有限公司 Anchoring device and anchoring instrument
US11918222B2 (en) 2022-03-30 2024-03-05 Cilag Gmbh International Stapling assembly having firing member viewing windows
US11918208B2 (en) 2022-04-12 2024-03-05 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US11918217B2 (en) 2022-04-25 2024-03-05 Cilag Gmbh International Stapling instrument comprising a staple cartridge insertion stop
US11925346B2 (en) 2022-05-20 2024-03-12 Cilag Gmbh International Surgical staple cartridge including tissue supporting surfaces
US11918210B2 (en) 2022-06-13 2024-03-05 Cilag Gmbh International Staple cartridge comprising a cartridge body including a plurality of wells

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EP1530442B1 (en) 2011-10-05
US20090216265A1 (en) 2009-08-27
WO2004019787A3 (en) 2004-06-17
US20140031841A1 (en) 2014-01-30
EP1530442A2 (en) 2005-05-18
JP4456482B2 (en) 2010-04-28
AU2003263892A1 (en) 2004-03-19
WO2004019787A2 (en) 2004-03-11
CA2463870A1 (en) 2004-03-11
ES2369537T3 (en) 2011-12-01
US8579935B2 (en) 2013-11-12
ATE526884T1 (en) 2011-10-15

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