US20040009135A1 - Hair growth formulation - Google Patents
Hair growth formulation Download PDFInfo
- Publication number
- US20040009135A1 US20040009135A1 US10/440,564 US44056403A US2004009135A1 US 20040009135 A1 US20040009135 A1 US 20040009135A1 US 44056403 A US44056403 A US 44056403A US 2004009135 A1 US2004009135 A1 US 2004009135A1
- Authority
- US
- United States
- Prior art keywords
- composition
- tocotrienols
- hair
- tocotrienol
- hair growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Definitions
- the present invention generally relates to a hair growth formulation, in particular to a formulation comprising tocotrienol for promoting hair growth.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a formulation for promoting hair growth and preventing hair loss. Supplementation with the formulation promotes hair growth and increases the number of hairs in mammals. In one embodiment, a composition for promoting hair growth and reducing hair loss according to the present invention comprises mixed tocotrienols and a pharmaceutically acceptable excipient.
Description
- This patent claims priority from the patent application of the same name filed in Malaysia on May 22, 2002 and assigned Malaysian patent application number PI20021894.
- The present invention generally relates to a hair growth formulation, in particular to a formulation comprising tocotrienol for promoting hair growth.
- Hair loss or alopecia is a common problem in both males and females regardless of their age. There are several types of hair loss, such as androgenetic alopecia, alopecia areata, telogen effluvium, hair loss due to systemic medical problems, e.g., thyroid disease, adverse drug effects and nutritional deficiency states as well as hair loss due to scalp or hair trauma, discoid lupus erythematosus, lichen planus and structural shaft abnormalities. (Hogan and Chamberlain, 2000). Of the above, androgenetic alopecia is the most common cause of hair loss, affecting about 30% of individuals who have a strong family history of hair loss. (Bergfeld, 1988). Androgenetic alopecia is caused by three interdependent factors: male hormone dihydrotestosterone (DHT), genetic disposition and advancing age. DHT causes hair follicle to degrade and further shrink in size, resulting in weak hairs. DHT also shortens the anagen phase of the hair follicle growing cycle. Over time, more hairs are shed and hairs become thinner. Possible options for the treatment of alopecia include reassurance, hair prosthesis, surgery and topical/oral medications. (Hogan & Chamberlain, 2000; Bertolino, 1993; Setty, 1970).
- The most common pharmacological management of androgenetic alopecia is topical minoxidil and finasteride taken orally. The main problem with topical minoxidil therapy is patient compliance, although it has been shown to be effective in a few studies. (DeVillez et al, 1994; Trancik R J, 1998). On the other hand, oral finasteride is associated with significant adverse effects such as decreased libido, impotence and ejaculation disorders. (Chen et al, 1996).
- In addition, there is report by Goldman et al. (1996) which evaluates whether male pattern baldness is associated with a deficiency in oxygen supply to body tissue. The results indicate that penetration of oxygen was lower in bald frontal scalp than in hair-bearing temporal scalp area. As such, good blood supply to the scalp is essential to maintain normal cycle of hair growth.
- Tocotrienol, a form of vitamin E, is a potent anti-oxidant and has been found useful in combating many health problems. While there was a report of the beneficial effects of vitamin E in hair care products (Shipp, 1994), its potential in the restoration of hair in patients taking tocotrienols as a supplement has yet to be explored. Thus, the aim of the present study was to investigate the possible intervention effects on hair loss with tocotrienols.
- Accordingly, it is the primary objective of the present invention to provide a mixed tocotrienols composition. It is also another objective to provide a formulation for promoting hair growth and preventing hair loss using the mixed tocotrienols of the present invention.
- This and other objectives of the present invention are accomplished by: (1) a mixed tocotrienols composition; (2) a formulation for promoting hair growth and preventing hair loss in a mammal wherein mixed tocotrienols are combined with a pharmaceutically acceptable excipient; (3) a formulation for promoting hair growth and preventing hair loss in a mammal wherein α-, or γ-, or δ-tocotrienols is combined with pharmaceutically acceptable excipient; and (4) the use of a formulation as claimed in the present invention for promoting hair growth and preventing hair loss in a mammal.
- The formulation according to the present invention, when administered orally or topically, promotes hair growth and prevents hair loss, and the number of hairs appears to increase in those persons experiencing hair loss.
- Other aspects of the present invention and their advantages will be discerned after studying the Detailed Description in conjunction with the accompanying figure in which:
- FIG. 1 shows the effect of the tocotrienol formulation according to the present invention on the mean number of hairs of volunteers after supplementation for 5 months.
- Effect of Tocotrienol Supplementation on Hair Growth:
- Study Design:
- A randomized, double blind, placebo-controlled two groups parallel study was conducted to compare the effect of a mixture of tocotrienols, comprising α-, γ-, and δ-tocotrienols and alpha-tocopherol, with placebo on hair growth. All volunteers were randomized to receive one capsule comprising either (i) a mixture of tocotrienols and alpha-tocopheral, or (ii) a placebo, twice daily after food over a period of at least 5 months. They were seen for an efficacy evaluation every month throughout the study. The control was a placebo capsule containing 600 mg of soya bean oil, and the tocotrienol formulation consisted of capsules containing a mixture of about 50 mg of tocotrienols and about 23 i.u. alpha-tocopherol. The entire study took 15 months for completion.
- Although the preferred embodiment of the formulation is in the form of soft gelatin capsule, other oral pharmaceutical dosage forms are not excluded. The preferred dosage range of tocotrienols for oral consumption is from about 20 mg to about 1500 mg/day. The formulation may also be applied topically and may be in the form of a cream, a lotion, an ointment, a gel, a liquid, or any other topical form. The concentration of tocotrienols used in the topical formulation is about 1.0%, and the minimum concentration of tocotrienols in any formulation is about 0.1%.
- Inclusion Criteria:
- Volunteers of 15 years of age or older and in good general health were recruited into the study. Alopecia must have present for least 2 months and the areas alopecia must not have any visual evidence of new hair growth. Volunteers previously exposed to minoxidil were ineligible to participate in the study, as were patients who have used hair-restorers or systemic drugs like steroids, antihypertensives, cytotoxic compounds, vasodilators, anticonvulsant drugs, β-blockers, spironolactone, cimetidine, ketoconazole, estrogens or progesterons within the previous three months. Patients experiencing hair loss due to thyroid disease, adverse drug reactions, scalp or hair trauma, structural hair shaft abnormalities and lichen planus were excluded from the study.
- Efficacy Evaluation:
- Two parameters were chosen to evaluate the efficacy of tocotrienols and alpha-tocopherol supplementation:
- i) Hair count—hair count served as the primary efficacy measure. An area of 2×2 cm was selected in the area of hair thinning for each patient, and the two opposing corners of the square were permanently marked (using a 4 cm2 wire template) to ensure that the hair in the same area was counted at each visit.
- ii) Weight of hair—a small tuft of hair (at least 20 strands) within the demarcated area was clipped horizontally. Twenty strands were randomly chosen and cut into 1 cm in length. The total weight was obtained using a microbalance and the mean weight was recorded.
- All the two parameters were obtained at baseline and every month thereafter during the study. Only the terminal hair growth was recorded and analyzed.
- Results of Hair Growth Studies:
- Nineteen patients (14 men and 5 women) entered the study and completed at least the first 5 months of therapy. Their ages ranged from 23 to 59 years. The mean duration of current alopecia episode was approximately 5 years. The extent of alopecia was as follows: less than 25%, 6 patients; 25-49%, 8 patients; 50-74%, 4 patients; 75-99%, 1 patient.
- Eleven volunteers were randomized to receive the tocotrienol formulation supplementation while 8 volunteers were in the placebo group. Comparability of the treatment groups with respect to initial hair counts as well as the weight of hair was assessed. No statistically significant difference between treatment groups was detected for any of the above characteristics.
- At the end of the supplementation period, all volunteers in the tocotrienol formulation group had positive results, recording an increase in the number of hair in the evaluation area. Seven volunteers (64%) showed regrowth of between 10-35% while 3 volunteers (27%) had 50% or greater regrowth. On volunteer had regrowth of more than 100%. The mean percentage of increase in the number of hairs is 42.4±40.9% (mean±SD). (Table 1 and FIG. 1). The increase is statistically significant (p<0.05) when analyzed using paired sample t-test. On the other hand, of the total eight volunteers in the placebo group, two showed hair regrowth, two had hair loss while the other four did not show any significant changes in the number of hairs. The mean percentage of increase was 1.4±13.8%. No statistically significant difference (p>0.05) in the number of hairs was detected between baseline and post-supplementation, thus indicating that the placebo effect did not occur during this study.
- However, in terms of the weight of the hair, no statistically significant difference (p>0.05) between pre- and post-supplementation was detected for both groups of volunteers (tocotrienol and placebo). The mean percentage of weight increment was 16.4±42.5% in the tocotrienol formulation group while that of the placebo group had an increase of 5.7±40.1%. (Table 2).
- The above-mentioned studies therefore indicate that supplementation with a formulation comprising a mixture of tocotrienol, alpha-tocopherol and pharmaceutically acceptable excipient appears to promote hair growth and increase the number of hair in persons experiencing hair loss. The choice of pharmaceutically acceptable excipients will be obvious to those skilled in the relevant art. Acceptable excipients include any inert, compatible substances added to make the final dosage forms, for the formulations, such as tablets, capsules, or soft gelatin capsules. For example, vegetable oil can be added as an excipient to make up the volume for the encapsulation of soft gelatin capsules. As such, a pharmaceutically acceptable excipient includes any excipients that are approved for use by the relevant authorities and are compatible with tocotrienols.
TABLE 1 Individual number of hair at baseline and 5 months after tocotrienol and placebo supplementation. Tocotrienol Placebo Volunteer Baseline 5 months % change Volunteer Baseline 5 months % change 1 290 477 64.5 1 194 244 25.8 2 380 463 21.8 2 391 385 −1.5 3 496 603 21.6 3 358 369 3.1 4 223 370 65.9 4 354 296 −16.4 5 110 133 20.9 5 223 258 15.7 6 266 358 34.6 6 286 267 −6.6 7 110 274 149.1 7 307 275 −10.4 8 258 298 15.5 8 219 223 1.8 9 314 344 9.6 10 287 316 10.1 11 179 274 53.1 Mean 264.8 355.5 42.4 Mean 291.5 289.6 1.4 SD 112.9 124.7 40.9 SD 73.6 58.2 13.8 -
TABLE 2 Individual weight of hair (g) at baseline and 5 months after tocotrienol and placebo supplementation. Tocotrienol Placebo Volunteer Baseline 5 months % change Volunteer Baseline 5 months % change 1 0.0920 0.1078 17.2 1 0.2280 0.1200 −47.4 2 0.0970 0.0962 −0.8 2 0.0915 0.0945 3.3 3 0.2490 0.2480 −0.4 3 0.1974 0.1956 −0.9 4 0.0732 0.1552 112.0 4 0.0822 0.1587 93.1 5 0.1055 0.0849 −19.5 5 0.1899 0.1789 −5.8 6 0.1315 0.1577 19.9 6 0.1158 0.1206 4.1 7 0.1094 0.1295 18.4 7 0.1398 0.1625 16.2 8 0.1405 0.1686 20.0 8 0.1187 0.0988 −16.8 9 0.1284 0.0837 −34.8 10 0.1380 0.2348 70.1 11 0.1692 0.1317 −22.2 Mean 0.1 0.1 16.4 Mean 0.1 0.1 5.7 SD 0.0 0.1 42.5 SD 0.1 0.0 40.1 - Bergfeld W F (1995). Androgenetic alopecia: an autosomal dominant disorder.Am J Med 98:95S-98S.
- Bertolino A P (1993). Clinical hair loss: diagnosis and treatment.J Dermatol 20:604-610.
- Chen W. Zouboulis and Cafanos C E (1996). The 5-alpha reductase system and its inhibitors.Dermatology 193:177-184.
- DeVillez R L, Jacobs J P, Szpunar C A & Warner M L (1994). Androgenetic alopecia in the female. Treatment with 5% topical minoxidil solution.Arch Dermatol 130:303-307.
- Goldman B E, Fisher D M and Ringler S L (1996). Transcutaneous PO2 of the scalp in male pattern baldness: a new piece to puzzle.Plast Reconstr Surg 97(6):1109-1116.
- Hogan D J and Chamberlain M (2000). Male pattern baldness.South Med J 93(7):657-662.
- Shipp J J (1994). Hair care products. In:Chemistry and technology of the cosmetics and toiletries industry. (Williams D F and Schmitt W H, ed.s), p 66. Blackie Academic & Professional: UK.
- Setty L R (1970). Hair pattern of the scalp of white and Negro males.Am J. Phys Anthropol 33:40-55.
- Trancik R J (1998). Update on topical minoxidil in hair loss.Annual Meeting of American Academy of Dermatology, Orlando.
- While the preferred embodiment of the present invention has been described, it should be understood that various changes, adaptations and modifications may be made thereto. It should be understood, therefore, that the invention is not limited to details of the illustrated invention shown in the figure and tables, and that variations in such minor details will be apparent to one skilled in the art.
Claims (30)
1. A composition for promoting hair growth and reducing hair loss comprising mixed tocotrienols and a pharmaceutically acceptable excipient, wherein the minimum concentration of said mixed tocotrienols is about 0.1%.
2. The composition of claim 1 , further comprising about 23 i.u. of alpha-tocopherol and wherein said mixed tocotrienols are comprised of a mixture of α-, γ-, and δ-tocotrienols.
3. The composition as in either claim 1 or claim 2 , wherein the amount of said mixed tocotrienols is about 50 mg.
4. The composition as in either claim 1 or claim 2 , wherein said composition is administered in the form of an oral dosage.
5. The composition of claim 4 , wherein said oral dosage is in the form of a soft gelatin capsule.
6. The composition of claim 4 , wherein the oral administration of said composition is at a dosage of about 20 mg-1500 mg per day.
7. The composition as in either claim 1 or claim 2 , wherein said composition is administered as a topical formulation selected from the group consisting of a cream, a lotion, an ointment, a gel, and a liquid.
8. The composition of claim 7 , wherein the concentration of said mixed tocotrienols is about 1.0%.
9. A method of promoting hair growth and reducing hair loss in a mammal comprising administering a composition comprised of mixed tocotrienols and a pharmaceutically acceptable excipient, wherein the minimum concentration of said mixed tocotrienols is about 0.1%
10. The method of claim 9 , wherein said mixed tocotrienols are comprised of a mixture of α-, γ-, and δ-tocotrienols.
11. The method as in either claim 9 or claim 10 , wherein said composition further comprises about 23 i.u. of alpha-tocopherol.
12. The method as in either claim 9 or claim 10 , wherein said composition is administered in the form of an oral dosage.
13. The method of claim 12 , wherein said oral dosage is in the form of a soft gelatin capsule.
14. The method of claim 12 , wherein the oral administration of said composition is at a dosage of about 20 mg-1500 mg per day.
15. The method as in either claim 9 or claim 10 , wherein said composition is administered as a topical formulation selected from the group consisting of a cream, a lotion, an ointment, a gel, and a liquid.
16. The method of claim 15 , wherein the concentration of said mixed tocotrienols is about 1.0%.
17. A composition for promoting hair growth and reducing hair loss comprising a pharmaceutically acceptable excipient and a tocotrienol selected from the group consisting of α-, γ-, and δ-tocotrienols, wherein the concentration of said tocotrienol is about 0.1%.
18. The composition of claim 17 , further comprising about 23 i.u. of alpha-tocopherol.
19. The composition of claim 17 , wherein said composition is administered in the form of an oral dosage.
20. The composition of claim 19 , wherein said oral dosage is in the form of a soft gelatin capsule.
21. The composition of claim 19 , wherein the oral administration of said composition is at a dosage of about 20 mg-1500 mg per day.
22. The composition of claim 17 , wherein said composition is administered as a topical formulation selected from the group consisting of a cream, a lotion, an ointment, a gel, and a liquid.
23. The composition of claim 22 , wherein said concentration of said tocotrienol is about 1.0%.
24. A method for promoting hair growth and reducing hair loss comprising administering a pharmaceutically acceptable excipient and a tocotrienol selected from the group consisting of α-, γ-, and δ-tocotrienols, wherein the concentration of said tocotrienol is about 0.1%.
25. The method of claim 24 , further comprising administering about 23 i.u. of alpha-tocopherol and wherein the amount of said mixed tocotrienols is about 50 mg.
26. The method of claim 24 , wherein said composition is administered in the form of an oral dosage.
27. The method of claim 26 , wherein said oral dosage is in the form of a soft gelatin capsule.
28. The method of claim 26 , wherein the oral administration of said composition is at a dosage of about 20 mg-1500 mg per day.
29. The method of claim 24 , wherein said composition is administered as a topical formulation selected from the group consisting of a cream, a lotion, an ointment, a gel, and a liquid.
30. The method of claim 29 , wherein the concentration of said tocotrienol is about 1.0%.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US11/120,268 US7211274B2 (en) | 2002-05-22 | 2005-05-02 | Hair growth formulation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MYPI20021894 | 2002-05-22 | ||
MYPI20021894A MY139332A (en) | 2002-05-22 | 2002-05-22 | Hair growth formulation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US11/120,268 Continuation US7211274B2 (en) | 2002-05-22 | 2005-05-02 | Hair growth formulation |
Publications (1)
Publication Number | Publication Date |
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US20040009135A1 true US20040009135A1 (en) | 2004-01-15 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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US10/440,564 Abandoned US20040009135A1 (en) | 2002-05-22 | 2003-05-17 | Hair growth formulation |
US11/120,268 Expired - Lifetime US7211274B2 (en) | 2002-05-22 | 2005-05-02 | Hair growth formulation |
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Application Number | Title | Priority Date | Filing Date |
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US11/120,268 Expired - Lifetime US7211274B2 (en) | 2002-05-22 | 2005-05-02 | Hair growth formulation |
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US (2) | US20040009135A1 (en) |
MY (1) | MY139332A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20060080792A1 (en) * | 2004-10-13 | 2006-04-20 | Gabin Vic | Film-forming composition for the cosmetic treatment of keratin materials comprising at least one electrophilic monomer and at least one non-silicone polymer |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8580236B2 (en) * | 2007-03-19 | 2013-11-12 | Richard P. De Maria | Hair sustaining formulation |
ES2517741B1 (en) * | 2013-04-30 | 2015-09-09 | Lacer, S.A. | Composition to reduce and / or prevent hair loss and / or stimulate its growth |
JP6189803B2 (en) * | 2014-07-30 | 2017-08-30 | 株式会社イムダイン | Orally administered hair growth and scalp improving agents |
Citations (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4439432A (en) * | 1982-03-22 | 1984-03-27 | Peat Raymond F | Treatment of progesterone deficiency and related conditions with a stable composition of progesterone and tocopherols |
US4551332A (en) * | 1981-08-05 | 1985-11-05 | Theodore Stillman | Vitamin E compositions and methods |
US5200214A (en) * | 1991-06-28 | 1993-04-06 | Wm. Wrigley Jr. Company | Tocopherol mixture for use as a mint oil antioxidant in chewing gum |
US5476661A (en) * | 1994-10-21 | 1995-12-19 | Elizabeth Arden Co., Division Of Conopco, Inc. | Compositions for topical application to skin, hair and nails |
US5554647A (en) * | 1989-10-12 | 1996-09-10 | Perricone; Nicholas V. | Method and compositions for treatment and/or prevention of skin damage and aging |
US5597575A (en) * | 1994-06-06 | 1997-01-28 | Breitbarth; Richard | Composition for stimulating and inducing hair growth |
US5620692A (en) * | 1993-12-23 | 1997-04-15 | Nurture, Inc. | Oat oil compositions with useful cosmetic and dermatological properties |
US5629002A (en) * | 1991-01-15 | 1997-05-13 | Weuffen; Wolfgang | Cosmetic or pharmaceutic preparations for improving hair quaility and stimulating growth of the hair |
US5635189A (en) * | 1993-09-03 | 1997-06-03 | Scotia Holdings Plc | Tocopherols |
US5643586A (en) * | 1995-04-27 | 1997-07-01 | Perricone; Nicholas V. | Topical compositions and methods for treatment of skin damage and aging using catecholamines and related compounds |
US5709686A (en) * | 1995-03-27 | 1998-01-20 | Synthes (U.S.A.) | Bone plate |
US5723149A (en) * | 1990-11-21 | 1998-03-03 | Lvmh Recherche | Use of medicago saponins for the preparation of cosmetic or pharmaceutical compositions, especially dermatological compositions, promoting renewal of the epidermis, stimulating hair regrowth or delaying hair loss |
US5750107A (en) * | 1993-02-12 | 1998-05-12 | Nomura; Manabu | Hair growth promoter |
US5879690A (en) * | 1995-09-07 | 1999-03-09 | Perricone; Nicholas V. | Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers |
US5965750A (en) * | 1995-10-17 | 1999-10-12 | Showa Denko K.K. | High- purity tocopherol phosphates, process for the preparation thereof, methods for analysis thereof, and cosmetics |
US6013279A (en) * | 1994-12-08 | 2000-01-11 | Klett-Loch; Lore Maria | Combination preparation for stimulating the growth of hair and optionally the growth of skin and nails as well as for preventing or eliminating the loss of hair |
US6057337A (en) * | 1998-02-02 | 2000-05-02 | Shiseido Co., Ltd. | 1,2-DI-substituted piperidine derivative, hair growth promoter and external composition for skin using the same |
US6139852A (en) * | 1997-03-26 | 2000-10-31 | Shiseido Company, Ltd. | Extract composition as hair growth phase extender |
US6365623B1 (en) * | 1997-11-17 | 2002-04-02 | Nicholas V. Perricone | Treatment of acne using lipoic acid |
US6365181B1 (en) * | 2000-04-20 | 2002-04-02 | Gattefosse Corporation | Thixatropic gelatin carrier composition |
US6369042B1 (en) * | 1998-05-04 | 2002-04-09 | Oberthuer Walter | Antioxidative vitamin B6 analogs |
US6410062B1 (en) * | 1999-06-03 | 2002-06-25 | Johnson & Johnson Consumer France Sas I3540 | Method for the topical treatment and prevention of inflammatory disorders and related conditions using extracts of feverfew (Tanacetum parthenium) |
US6429231B1 (en) * | 2001-09-24 | 2002-08-06 | Bradley Pharmaceuticals, Inc. | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use |
US6491902B2 (en) * | 2001-01-29 | 2002-12-10 | Salvona Llc | Controlled delivery system for hair care products |
US20030182679A1 (en) * | 2000-09-19 | 2003-09-25 | Michael Geiger | Improved method for the biosynthesis of vitamin e |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2124086A1 (en) * | 1991-11-22 | 1993-05-27 | Ronald H. Lane | Tocotrienols and tocotrienol-like compounds and methods for their use |
US5545398A (en) * | 1993-01-13 | 1996-08-13 | Perricone; Nicholos V. | Method and compositions for topical application to the skin of tocotrienol for prevention and/or treatment of skin damage |
JP2000038340A (en) * | 1998-05-20 | 2000-02-08 | Kumahiro Miyama | Hair grower and food |
-
2002
- 2002-05-22 MY MYPI20021894A patent/MY139332A/en unknown
-
2003
- 2003-05-17 US US10/440,564 patent/US20040009135A1/en not_active Abandoned
-
2005
- 2005-05-02 US US11/120,268 patent/US7211274B2/en not_active Expired - Lifetime
Patent Citations (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4551332A (en) * | 1981-08-05 | 1985-11-05 | Theodore Stillman | Vitamin E compositions and methods |
US4439432A (en) * | 1982-03-22 | 1984-03-27 | Peat Raymond F | Treatment of progesterone deficiency and related conditions with a stable composition of progesterone and tocopherols |
US5554647A (en) * | 1989-10-12 | 1996-09-10 | Perricone; Nicholas V. | Method and compositions for treatment and/or prevention of skin damage and aging |
US5723149A (en) * | 1990-11-21 | 1998-03-03 | Lvmh Recherche | Use of medicago saponins for the preparation of cosmetic or pharmaceutical compositions, especially dermatological compositions, promoting renewal of the epidermis, stimulating hair regrowth or delaying hair loss |
US5629002A (en) * | 1991-01-15 | 1997-05-13 | Weuffen; Wolfgang | Cosmetic or pharmaceutic preparations for improving hair quaility and stimulating growth of the hair |
US5200214A (en) * | 1991-06-28 | 1993-04-06 | Wm. Wrigley Jr. Company | Tocopherol mixture for use as a mint oil antioxidant in chewing gum |
US5750107A (en) * | 1993-02-12 | 1998-05-12 | Nomura; Manabu | Hair growth promoter |
US5635189A (en) * | 1993-09-03 | 1997-06-03 | Scotia Holdings Plc | Tocopherols |
US5620692A (en) * | 1993-12-23 | 1997-04-15 | Nurture, Inc. | Oat oil compositions with useful cosmetic and dermatological properties |
US5597575A (en) * | 1994-06-06 | 1997-01-28 | Breitbarth; Richard | Composition for stimulating and inducing hair growth |
US5476661A (en) * | 1994-10-21 | 1995-12-19 | Elizabeth Arden Co., Division Of Conopco, Inc. | Compositions for topical application to skin, hair and nails |
US6013279A (en) * | 1994-12-08 | 2000-01-11 | Klett-Loch; Lore Maria | Combination preparation for stimulating the growth of hair and optionally the growth of skin and nails as well as for preventing or eliminating the loss of hair |
US5709686A (en) * | 1995-03-27 | 1998-01-20 | Synthes (U.S.A.) | Bone plate |
US5643586A (en) * | 1995-04-27 | 1997-07-01 | Perricone; Nicholas V. | Topical compositions and methods for treatment of skin damage and aging using catecholamines and related compounds |
US5879690A (en) * | 1995-09-07 | 1999-03-09 | Perricone; Nicholas V. | Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers |
US5965750A (en) * | 1995-10-17 | 1999-10-12 | Showa Denko K.K. | High- purity tocopherol phosphates, process for the preparation thereof, methods for analysis thereof, and cosmetics |
US6046181A (en) * | 1995-10-17 | 2000-04-04 | Showa Denko K.K. | Highly purified tocopheryl phosphate, process for producing the same, analytical method therefor and cosmetic |
US6139852A (en) * | 1997-03-26 | 2000-10-31 | Shiseido Company, Ltd. | Extract composition as hair growth phase extender |
US6365623B1 (en) * | 1997-11-17 | 2002-04-02 | Nicholas V. Perricone | Treatment of acne using lipoic acid |
US6057337A (en) * | 1998-02-02 | 2000-05-02 | Shiseido Co., Ltd. | 1,2-DI-substituted piperidine derivative, hair growth promoter and external composition for skin using the same |
US6369042B1 (en) * | 1998-05-04 | 2002-04-09 | Oberthuer Walter | Antioxidative vitamin B6 analogs |
US6410062B1 (en) * | 1999-06-03 | 2002-06-25 | Johnson & Johnson Consumer France Sas I3540 | Method for the topical treatment and prevention of inflammatory disorders and related conditions using extracts of feverfew (Tanacetum parthenium) |
US6365181B1 (en) * | 2000-04-20 | 2002-04-02 | Gattefosse Corporation | Thixatropic gelatin carrier composition |
US20030182679A1 (en) * | 2000-09-19 | 2003-09-25 | Michael Geiger | Improved method for the biosynthesis of vitamin e |
US6491902B2 (en) * | 2001-01-29 | 2002-12-10 | Salvona Llc | Controlled delivery system for hair care products |
US6429231B1 (en) * | 2001-09-24 | 2002-08-06 | Bradley Pharmaceuticals, Inc. | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20060080792A1 (en) * | 2004-10-13 | 2006-04-20 | Gabin Vic | Film-forming composition for the cosmetic treatment of keratin materials comprising at least one electrophilic monomer and at least one non-silicone polymer |
Also Published As
Publication number | Publication date |
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US7211274B2 (en) | 2007-05-01 |
US20050191260A1 (en) | 2005-09-01 |
MY139332A (en) | 2009-09-30 |
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