US20030125798A1 - Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium - Google Patents
Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium Download PDFInfo
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- US20030125798A1 US20030125798A1 US10/365,458 US36545803A US2003125798A1 US 20030125798 A1 US20030125798 A1 US 20030125798A1 US 36545803 A US36545803 A US 36545803A US 2003125798 A1 US2003125798 A1 US 2003125798A1
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- stent
- tubular member
- stent according
- coronary sinus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2493—Transmyocardial revascularisation [TMR] devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
- A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
- A61B2017/00252—Making holes in the wall of the heart, e.g. laser Myocardial revascularization for by-pass connections, i.e. connections from heart chamber to blood vessel or from blood vessel to blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0037—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in height or in length
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
Definitions
- the present invention relates to a stent for supplying oxygenated blood retrogradely to the myocardium via the coronary sinus.
- the stent directs blood from the left ventricle to the coronary sinus through a hole punctured through the wall of the coronary sinus and the wall of the left ventricle and restricting the outflow of the coronary sinus directs that blood retrogradely.
- Retrograde perfusion using the coronary sinus has long been known for treating end-stage heart disease.
- Previous methods among others attempted to connect the aorta to the coronary sinus using a jugular vein or an internal mammary artery graft. These methods were invasive in nature and required open heart surgery.
- U.S. Pat. No. 5,824,071 issued to Nelson et al. in 1998, discloses an apparatus and method for providing retrograde perfusion directly from the left ventricle to the coronary sinus.
- Nelson requires a pressure sensitive valve that prevents pressure build-up inside the coronary sinus from rising above 60 mm Hg.
- Nelson does not teach how such a valve may be constructed, and it is unlikely that such a device may be introduced percutaneously.
- Patel et al. conducted experiments for percutaneous arterialization of the coronary sinus using a stent. See Patel et al., Percutaneous Transmyocardial Intracardiac Retroperfusion Shunts: Technical Feasibility in a Canine Model , JVIR 2000, 11:382-390.
- the stent employed by Patel et al. results in a significant shunt of oxygenating blood from the left ventricle to the right atrium (hereinafter “left-to-right shunt”).
- Patel recommends using a T or a Y shaped device, technical problems associated with accurately delivering such a device in place render the invention difficult. These factors argue for a simpler device for providing retrograde perfusion to the heart via the coronary sinus.
- the present invention contemplates a stent having a leading end and a trailing end and having a passageway therethrough. After delivery, the body of the stent is expanded or self expands to fit securely within the coronary sinus.
- the leading end of the stent (hereinafter “leading (LV) end) is positioned in the left ventricle, and the trailing end (hereinafter “trailing (RA)end”) is preferably positioned in the right atrium.
- the stent preferably has reduced cross sectional areas or smaller passageways (or constrictions) at or near the leading (LV) end and the trailing (RA) end as compared to the remainder of the stent.
- the size of the passageway decreases or tapers preferably toward the leading (LV) end and toward the trailing (RA) end. Accordingly, as blood flows through the small passageway of the leading (LV) end, the passageway broadens in cross sectional area toward the midsection of the stent and decreases again toward the small passageway of the training (RA) end.
- the smaller passageways (or constrictions) at or near the leading (LV) end and the trailing (RA) end of the stent operate to control the amount of blood flowing into and out of the coronary sinus.
- the size of the passageway of the constriction at the leading (LV) end controls the amount of inflow into the coronary sinus.
- the cover surrounding the stent at the trailing (RA) end directs blood flow through the passageway at the trailing (RA) end, and the size of the passageway of the constriction at or near the trailing (RA) end controls the amount of outflow into the right atrium. They also control the retrograde flow of oxygenated blood to the myocardium.
- the stent preferably forms a friction fit with the lumen of the coronary sinus.
- the stent is expandable cross-sectionally, and preferably compressible cross-sectionally.
- a stent may be fit within a catheter for delivery. After percutaneous delivery into its desired position, the stent may self expand to form a friction fit within the coronary sinus. If a stent does not self expand, it may be expanded using a balloon as known in the art or other suitable mechanism. Once expanded, such a stent may or may not be further compressible cross sectionally.
- the present invention also contemplates materials well known in the art, including but not limited to stainless steel, nitinol, or plastic.
- the stent is also made of a flexible material as known in the art that allows bending without forming a kink.
- the present invention also contemplates a percutaneous method for delivering and placing a stent of the present invention to allow blood flow from the left ventricle to the coronary sinus.
- a hole punctured percutaneously through the wall of the coronary sinus and the wall of the left ventricle creates a passageway for blood flow between the left ventricle and the coronary sinus.
- the hole is dilated using a balloon as known in the art.
- the sheath of the catheter is removed to expose the stent.
- the stent forms a friction fit with the interior wall of the coronary sinus as it expands.
- the trailing (RA) end preferably but not necessarily protrudes through the coronary ostium and extends into the right atrium.
- the leading (LV) end protrudes through the hole in the wall of the coronary sinus and the wall of the left ventricle to extend into the left ventricle.
- the smaller passageway and the cover of the trailing (RA) end restrict blood flow into the right atrium.
- the cross sectional area (or diameter) of the passageway at the trailing (RA) end (or constriction) should be large enough to prevent the coronary sinus pressure from rising above a suitable pressure, preferably about 50 mm Hg, while reducing a significant amount of left-to-right shunt.
- a suitable pressure limit avoids damage to the venous system draining into the coronary sinus while effectively providing retrograde perfusion.
- An optional covering at the leading (LV) end of the stent will help direct blood through the constriction at the leading (LV) end.
- the present invention overcomes the difficulty in the prior art with an elegant and simple stent that retrogradely supplies oxygenated blood to the myocardium while decreasing the shunting of oxygenated blood from the left ventricle to the right atrium.
- FIG. 1 shows a preferred embodiment of a stent having a wire-mesh construction and the cross sectional area of the stent tapering toward the leading (LV) end and toward the trailing (RA) end, with a covering around the trailing (RA) end.
- FIG. 2 shows the stent of FIG. 1 in place in a schematic diagram of the human heart.
- FIG. 3 shows an alternative embodiment of a stent comprising a coiled-type construction.
- FIG. 4 shows an alternative embodiment of a stent having flaring ends with constrictions near the trailing end and the leading end.
- FIG. 1 A preferred embodiment of a stent contemplated in the present invention is illustrated in FIG. 1.
- An object of the invention is to provide a novel stent 101 which may be placed percutaneously to communicate oxygenated blood from the left ventricle to the coronary sinus.
- the stent 101 generally comprises a tubular member having a leading (LV) end 105 and a trailing (RA) end 109 and having an axial passageway therethrough.
- the stent 101 has relatively smaller passageways or smaller cross sectional areas (or constrictions) at or near the leading (LV) end 105 and the trailing (RA) end 109 as compared to the rest of the stent 101 .
- the cross sectional area (or the diameter) of the stent 101 tapers toward or near the leading (LV) end 105 and the trailing (RA) end 109 .
- the cross sectional area (or diameter) enlarges toward the midsection of the stent 101 and decreases toward the trailing (RA) end 109 .
- the diameter may be constant substantially in the mid section of the stent.
- the stent 101 at the trailing (RA) end 109 is preferably surrounded with a cover 120 made of suitable material.
- the stent 101 at the leading (LV) end may also be surrounded with a cover (not pictured).
- the smaller passageway (or constricition) and the cover at the trailing (RA) end 109 help to direct blood retrogradely and to prevent a significant amount of left-to-right shunt.
- the smaller passageway of the leading end 105 controls the amount of blood entering the coronary sinus from the left ventricle. Increasing the size of the passageway at the leading end increases the amount of blood flow, and decreasing the size of the passageway decreases the amount of blood flow.
- the cover 120 directs blood flow towards the passageway at the trailing (RA) end 109 . By restricting flow into the right atrium, the increased pressure inside the coronary sinus promotes the blood to flow retrogradely to the heart tissue.
- the stent 101 has a wire-mesh construction with one or more interstices 113 .
- the stent is preferably woven or designed to exhibit the constrictions upon expansion.
- open architecture stents as known in the art may be employed.
- the stent 401 may also have a coiled construction with multiple interstices 413 .
- the stent 401 in FIG. 3 also has a leading (LV) end 405 and a trailing (RA) end 409 , with the stent 401 tapering toward the leading (LV) end 405 and toward the trailing (RA) and 409 .
- the stent 101 should also be made of a flexible material that can withstand bending without kinking.
- the stent 101 should maintain a fluid passageway therethrough to allow sufficient blood flow.
- the stent 101 may be made of a variety of commercially available materials.
- Metallic stents as well as non-metallic stents as known in the art may be used in the construction of the stent 101 .
- Non-metallic stents, for example, may be made of a suitable plastic material.
- the stent 101 is made of surgical-grade stainless steel or nitinol.
- the stent 101 of FIG. 2 is positioned in a schematic diagram of the human heart 200 .
- the heart 200 generally comprises a left ventricle 202 , a left atrium 206 , a right ventricle 222 , and a right atrium 210 .
- the left ventricle 202 is primarily responsible for delivery of oxygenated blood to the body.
- the left atrium 206 receives the oxygenated blood from the lungs, which is then delivered to the left ventricle 202 .
- the right atrium 210 is primarily responsible for receiving the deoxygenated blood from the body.
- the deoxygenated blood then flows into the right ventricle 222 before being sent to the lungs for oxygenation.
- the deoxygenated blood normally drains through the coronary sinus 218 into the right atrium 210 .
- the coronary ostium 226 separates the right atrium 210 and the coronary sinus 218 .
- a hole 220 is first punctured percutaneously through the wall of the coronary sinus 218 and the wall of the left ventricle 202 under fluoroscopic control using a needle and a stiff guide. Access is preferably from the internal jugular vein but may also be from the femoral vein. The hole 220 is then widened using a balloon as known in the art or by some other suitable method.
- a catheter encasing the compressed stent 101 is introduced and placed into position before removing the sheath to expose the stent 101 .
- the method used by Patel et al. may be employed in delivering the stent according to the present invention.
- Patel et al. Percutaneous Transmyocardial Intracardiac Retroperfusion Shunts: Technical Feasibility in a Canine Model , JVIR 2000, 11:382-290.
- Patel et al. modifies the stent delivery method as described by Rösch et al. in Rösch et al., Coaxial Catheter - Needle System for Transjugular Portal Vein Entrance , JVIR, Volume 4, No. 1. pp. 145-147, 1993.
- the stent may also be marked with appropriate platinum markers to aid fluoroscopic placement.
- the stent 101 preferably has variable cross sectional area or diameter along the tubular member.
- the diameter of the passageway at the trailing (RA) end 109 is preferably from about 1 mm to about 6 mm, and more preferably from about 2 mm to about 4 mm.
- the diameter of the passageway at the leading (LV) end 105 is preferably from about 1 mm to about 6 mm, and more preferably from about 2 mm to about 4 mm.
- the diameter increases from the leading (LV) end 105 to the midsection of the stent and decreases again toward the trailing (RA) end 109 .
- the diameter in the middle portion of the stent may also be constant or may vary.
- the largest diameter of the stent 101 is preferably from about 6 mm to about 15 mm.
- the passageway therefore may taper or constrict toward each constriction at or near each end 109 or 105 .
- the stent 101 is positioned as follows.
- the stent 101 is positioned to fit substantially within the coronary sinus 218 to preferably form a friction fit.
- the leading (LV) end 105 of the stent 101 protrudes through the hole 220 and extends into the left ventricle 202 .
- the leading (LV) end 105 extends preferably from about 2 mm to about 10 mm into the left ventricle 202 .
- the trailing (RA) end 109 of the stent 101 preferably protrudes past the coronary ostium 226 into the right atrium 210 .
- the trailing (RA) end 109 protrudes preferably from about 2 mm to about 10 mm into the right atrium 210 .
- the trailing (RA) end may be within the coronary sinus.
- An optional cover (not shown) may also be placed around the leading (LV) end 105 to guarantee the inflow cross sectional area or to guarantee that blood will flow through the constriction at the leading (LV) end.
- a cover 120 surrounds the stent 101 near the trailing (RA) end 109 .
- the cover directs the blood into the stent through the passageway or constriction at or near the trailing (RA) end 109 , then to the right atrium 210 .
- the cover 120 helps in controlling the amount of blood flow through the coronary ostium 226 .
- the cover 120 is preferably made of a number of commercially available materials, such as PET, PTFE, etc.
- the cover 120 preferably covers from about 0.5 cm to about 4 cm of the trailing end 109 of the stent 101 and more preferably from about 1 cm to about 3 cm of the trailing (RA) end 109 of the stent 101 .
- Blood flowing from the left ventricle 202 into the coronary sinus 218 is also directed through the uncovered interstices 113 in the stent 101 to provide retrograde perfusion to the myocardium because of the increased coronary sinus pressure caused by the small passageway at the trailing (RA) end.
- Blood flowing through the coronary ostium 226 is also controlled by controlling the size of the passageway or constriction at or near the leading (LV) end 105 . If the flow rate through the passageway at the trailing (RA) end 109 into the right atrium is too great, the heart tissue would not adequately be perfused and there would be a large left-to-right shunt. If, however, the size of the passageway at the trailing (RA) end 109 is too small, pressure build up within the coronary sinus 218 would damage the venous system being perfused retrogradely. Preferably, the pressure within the coronary sinus should not exceed a suitable pressure range to avoid damage to the coronary sinus venous system. For example, the pressure should not exceed approximately 50 mm Hg. Thus, the passageway at the trailing (RA) end 109 should be large enough to prevent excess pressure build up, but restrictive enough to allow the heart to be supplied with oxygenated blood.
- Coronary sinus pressure may also be controlled by controlling the amount of blood flowing from the left ventricle 202 into the coronary sinus 218 .
- the size of the passageway at the leading (LV) end 105 may be controlled in relation to the size of the passageway at the trailing (RA) end 109 to provide efficient retrograde perfusion of heart tissue without excessive pressure build up.
- the smallest diameters or constrictions of the stent 501 are not at the leading (LV) end 505 and the trailing (RA) end 509 , but preferably approximately 5 mm to about 2 cm from the leading (LV) end 505 and the trailing (RA) end 509 .
- the stent would have one or two flaring ends.
- the smallest cross sectional areas would be at constrictions 520 and 522 , which are near the leading (LV) end 505 and the trailing (RA) end 509 , respectively.
- a stent having a constant cross sectional area throughout its length is constricted at or near the ends so that the cross sectional areas at the constrictions are limited.
- Such constrictions may be woven into the stent design or applied by constricting material or other materials and/or mean as known in the art, e.g., using suture, band, wire, or tape.
- the cover itself may limit the cross sectional area of the stent.
Abstract
The present invention concerns a novel stent and a method for communicating oxygenated blood directly from the left ventricle to the coronary sinus to provide retrograde perfusion to the myocardium. The stent is placed substantially within the coronary sinus with its trailing end protruding into the right atrium and the leading end protruding into the left ventricle. The stent has a smaller passageway at or near the trailing (right ventricular) end and at or near the leading (left ventricle) end, and has a covering at the trailing end. The smaller passageway and the cover at the trailing end to promote retrograde flow into the venous system of the hear and specifically the myocardium of the left ventricle and to reduce a significant left-to-right shunt.
Description
- This application is a continuation-in-part of copending application Ser. No. 09/796,528, filed Mar. 2, 2001.
- 1. Field of Invention
- The present invention relates to a stent for supplying oxygenated blood retrogradely to the myocardium via the coronary sinus. The stent directs blood from the left ventricle to the coronary sinus through a hole punctured through the wall of the coronary sinus and the wall of the left ventricle and restricting the outflow of the coronary sinus directs that blood retrogradely.
- 2. Description of Related Technology
- Retrograde perfusion using the coronary sinus has long been known for treating end-stage heart disease. Previous methods among others attempted to connect the aorta to the coronary sinus using a jugular vein or an internal mammary artery graft. These methods were invasive in nature and required open heart surgery.
- U.S. Pat. No. 5,824,071, issued to Nelson et al. in 1998, discloses an apparatus and method for providing retrograde perfusion directly from the left ventricle to the coronary sinus. Nelson requires a pressure sensitive valve that prevents pressure build-up inside the coronary sinus from rising above 60 mm Hg. Nelson, however, does not teach how such a valve may be constructed, and it is unlikely that such a device may be introduced percutaneously.
- In 2000, Patel et al. conducted experiments for percutaneous arterialization of the coronary sinus using a stent. See Patel et al.,Percutaneous Transmyocardial Intracardiac Retroperfusion Shunts: Technical Feasibility in a Canine Model, JVIR 2000, 11:382-390. The stent employed by Patel et al., however, results in a significant shunt of oxygenating blood from the left ventricle to the right atrium (hereinafter “left-to-right shunt”). Further, although Patel recommends using a T or a Y shaped device, technical problems associated with accurately delivering such a device in place render the invention difficult. These factors argue for a simpler device for providing retrograde perfusion to the heart via the coronary sinus.
- It is an object of the present invention to provide a novel stent and a method for providing oxygenated blood retrogradely from the left ventricle to the heart tissue through the coronary sinus without a significant left-to-right shunt.
- In a preferred embodiment, the present invention contemplates a stent having a leading end and a trailing end and having a passageway therethrough. After delivery, the body of the stent is expanded or self expands to fit securely within the coronary sinus. The leading end of the stent (hereinafter “leading (LV) end) is positioned in the left ventricle, and the trailing end (hereinafter “trailing (RA)end”) is preferably positioned in the right atrium.
- The stent preferably has reduced cross sectional areas or smaller passageways (or constrictions) at or near the leading (LV) end and the trailing (RA) end as compared to the remainder of the stent. The size of the passageway decreases or tapers preferably toward the leading (LV) end and toward the trailing (RA) end. Accordingly, as blood flows through the small passageway of the leading (LV) end, the passageway broadens in cross sectional area toward the midsection of the stent and decreases again toward the small passageway of the training (RA) end.
- The smaller passageways (or constrictions) at or near the leading (LV) end and the trailing (RA) end of the stent operate to control the amount of blood flowing into and out of the coronary sinus. The size of the passageway of the constriction at the leading (LV) end controls the amount of inflow into the coronary sinus.
- The cover surrounding the stent at the trailing (RA) end directs blood flow through the passageway at the trailing (RA) end, and the size of the passageway of the constriction at or near the trailing (RA) end controls the amount of outflow into the right atrium. They also control the retrograde flow of oxygenated blood to the myocardium. The stent preferably forms a friction fit with the lumen of the coronary sinus.
- The stent is expandable cross-sectionally, and preferably compressible cross-sectionally. For example, a stent may be fit within a catheter for delivery. After percutaneous delivery into its desired position, the stent may self expand to form a friction fit within the coronary sinus. If a stent does not self expand, it may be expanded using a balloon as known in the art or other suitable mechanism. Once expanded, such a stent may or may not be further compressible cross sectionally. The present invention also contemplates materials well known in the art, including but not limited to stainless steel, nitinol, or plastic. The stent is also made of a flexible material as known in the art that allows bending without forming a kink.
- The present invention also contemplates a percutaneous method for delivering and placing a stent of the present invention to allow blood flow from the left ventricle to the coronary sinus. A hole punctured percutaneously through the wall of the coronary sinus and the wall of the left ventricle creates a passageway for blood flow between the left ventricle and the coronary sinus. The hole is dilated using a balloon as known in the art. After the stent is delivered and positioned between the left ventricle and the right atrium, the sheath of the catheter is removed to expose the stent. Preferably, the stent forms a friction fit with the interior wall of the coronary sinus as it expands. The trailing (RA) end preferably but not necessarily protrudes through the coronary ostium and extends into the right atrium. The leading (LV) end protrudes through the hole in the wall of the coronary sinus and the wall of the left ventricle to extend into the left ventricle.
- In the present invention, the smaller passageway and the cover of the trailing (RA) end restrict blood flow into the right atrium. With the increased pressure inside the coronary sinus, blood flows out through the open interstices of the stent retrogradely to perfuse the myocardium.
- Some amount of blood flow into the right atrium through the coronary ostium, however, is necessary to control the pressure in the coronary sinus. The cross sectional area (or diameter) of the passageway at the trailing (RA) end (or constriction) should be large enough to prevent the coronary sinus pressure from rising above a suitable pressure, preferably about 50 mm Hg, while reducing a significant amount of left-to-right shunt. A suitable pressure limit avoids damage to the venous system draining into the coronary sinus while effectively providing retrograde perfusion. An optional covering at the leading (LV) end of the stent will help direct blood through the constriction at the leading (LV) end.
- Thus, the present invention overcomes the difficulty in the prior art with an elegant and simple stent that retrogradely supplies oxygenated blood to the myocardium while decreasing the shunting of oxygenated blood from the left ventricle to the right atrium.
- FIG. 1 shows a preferred embodiment of a stent having a wire-mesh construction and the cross sectional area of the stent tapering toward the leading (LV) end and toward the trailing (RA) end, with a covering around the trailing (RA) end.
- FIG. 2 shows the stent of FIG. 1 in place in a schematic diagram of the human heart.
- FIG. 3 shows an alternative embodiment of a stent comprising a coiled-type construction.
- FIG. 4 shows an alternative embodiment of a stent having flaring ends with constrictions near the trailing end and the leading end.
- A preferred embodiment of a stent contemplated in the present invention is illustrated in FIG. 1. An object of the invention is to provide a
novel stent 101 which may be placed percutaneously to communicate oxygenated blood from the left ventricle to the coronary sinus. Thestent 101 generally comprises a tubular member having a leading (LV)end 105 and a trailing (RA)end 109 and having an axial passageway therethrough. - According to the present embodiment, the
stent 101 has relatively smaller passageways or smaller cross sectional areas (or constrictions) at or near the leading (LV)end 105 and the trailing (RA)end 109 as compared to the rest of thestent 101. Thus, the cross sectional area (or the diameter) of thestent 101 tapers toward or near the leading (LV)end 105 and the trailing (RA)end 109. The cross sectional area (or diameter) enlarges toward the midsection of thestent 101 and decreases toward the trailing (RA)end 109. The diameter may be constant substantially in the mid section of the stent. Thestent 101 at the trailing (RA)end 109 is preferably surrounded with acover 120 made of suitable material. Thestent 101 at the leading (LV) end may also be surrounded with a cover (not pictured). - The smaller passageway (or constricition) and the cover at the trailing (RA) end109 help to direct blood retrogradely and to prevent a significant amount of left-to-right shunt. The smaller passageway of the
leading end 105 controls the amount of blood entering the coronary sinus from the left ventricle. Increasing the size of the passageway at the leading end increases the amount of blood flow, and decreasing the size of the passageway decreases the amount of blood flow. As thestent 101 expands to fit securely within the coronary sinus, thecover 120 directs blood flow towards the passageway at the trailing (RA)end 109. By restricting flow into the right atrium, the increased pressure inside the coronary sinus promotes the blood to flow retrogradely to the heart tissue. - A number of suitable commercially available stents having the desired characteristics may be employed in practicing the present invention. Generally, the
stent 101 has a wire-mesh construction with one or more interstices 113. Numerous variations in wire mesh designs and weave configurations are known in the art. The stent is preferably woven or designed to exhibit the constrictions upon expansion. In other embodiments, open architecture stents as known in the art may be employed. As seen in FIG. 3, thestent 401 may also have a coiled construction withmultiple interstices 413. Thestent 401 in FIG. 3 also has a leading (LV)end 405 and a trailing (RA)end 409, with thestent 401 tapering toward the leading (LV)end 405 and toward the trailing (RA) and 409. - The
stent 101 should also be made of a flexible material that can withstand bending without kinking. Thestent 101 should maintain a fluid passageway therethrough to allow sufficient blood flow. Thestent 101 may be made of a variety of commercially available materials. Metallic stents as well as non-metallic stents as known in the art may be used in the construction of thestent 101. Non-metallic stents, for example, may be made of a suitable plastic material. In a preferred embodiment, thestent 101 is made of surgical-grade stainless steel or nitinol. - Referring now to FIG. 2, the
stent 101 of FIG. 2 is positioned in a schematic diagram of thehuman heart 200. Theheart 200 generally comprises aleft ventricle 202, aleft atrium 206, aright ventricle 222, and aright atrium 210. Theleft ventricle 202 is primarily responsible for delivery of oxygenated blood to the body. Theleft atrium 206 receives the oxygenated blood from the lungs, which is then delivered to theleft ventricle 202. Theright atrium 210 is primarily responsible for receiving the deoxygenated blood from the body. The deoxygenated blood then flows into theright ventricle 222 before being sent to the lungs for oxygenation. - After perfusing the heart, the deoxygenated blood normally drains through the
coronary sinus 218 into theright atrium 210. Thecoronary ostium 226 separates theright atrium 210 and thecoronary sinus 218. - To place the stent, a
hole 220 is first punctured percutaneously through the wall of thecoronary sinus 218 and the wall of theleft ventricle 202 under fluoroscopic control using a needle and a stiff guide. Access is preferably from the internal jugular vein but may also be from the femoral vein. Thehole 220 is then widened using a balloon as known in the art or by some other suitable method. In a preferred embodiment, a catheter encasing thecompressed stent 101 is introduced and placed into position before removing the sheath to expose thestent 101. The method used by Patel et al., may be employed in delivering the stent according to the present invention. Patel et al., Percutaneous Transmyocardial Intracardiac Retroperfusion Shunts: Technical Feasibility in a Canine Model, JVIR 2000, 11:382-290. Patel et al. modifies the stent delivery method as described by Rösch et al. in Rösch et al., Coaxial Catheter-Needle System for Transjugular Portal Vein Entrance, JVIR, Volume 4, No. 1. pp. 145-147, 1993. The stent may also be marked with appropriate platinum markers to aid fluoroscopic placement. - Referring again to FIG. 1, the
stent 101 preferably has variable cross sectional area or diameter along the tubular member. The diameter of the passageway at the trailing (RA)end 109 is preferably from about 1 mm to about 6 mm, and more preferably from about 2 mm to about 4 mm. Likewise, the diameter of the passageway at the leading (LV)end 105 is preferably from about 1 mm to about 6 mm, and more preferably from about 2 mm to about 4 mm. The diameter increases from the leading (LV) end 105 to the midsection of the stent and decreases again toward the trailing (RA)end 109. The diameter in the middle portion of the stent may also be constant or may vary. The largest diameter of thestent 101 is preferably from about 6 mm to about 15 mm. The passageway therefore may taper or constrict toward each constriction at or near eachend - Referring now to FIG. 2, the
stent 101 is positioned as follows. Thestent 101 is positioned to fit substantially within thecoronary sinus 218 to preferably form a friction fit. The leading (LV) end 105 of thestent 101 protrudes through thehole 220 and extends into theleft ventricle 202. The leading (LV)end 105 extends preferably from about 2 mm to about 10 mm into theleft ventricle 202. The trailing (RA) end 109 of thestent 101 preferably protrudes past thecoronary ostium 226 into theright atrium 210. The trailing (RA) end 109 protrudes preferably from about 2 mm to about 10 mm into theright atrium 210. In other embodiments, the trailing (RA) end may be within the coronary sinus. An optional cover (not shown) may also be placed around the leading (LV) end 105 to guarantee the inflow cross sectional area or to guarantee that blood will flow through the constriction at the leading (LV) end. - As discussed, a
cover 120 surrounds thestent 101 near the trailing (RA)end 109. As blood flows toward theright atrium 210, the cover directs the blood into the stent through the passageway or constriction at or near the trailing (RA)end 109, then to theright atrium 210. Thus, thecover 120 helps in controlling the amount of blood flow through thecoronary ostium 226. Thecover 120 is preferably made of a number of commercially available materials, such as PET, PTFE, etc. Thecover 120 preferably covers from about 0.5 cm to about 4 cm of the trailingend 109 of thestent 101 and more preferably from about 1 cm to about 3 cm of the trailing (RA) end 109 of thestent 101. Blood flowing from theleft ventricle 202 into thecoronary sinus 218 is also directed through the uncoveredinterstices 113 in thestent 101 to provide retrograde perfusion to the myocardium because of the increased coronary sinus pressure caused by the small passageway at the trailing (RA) end. - Blood flowing through the
coronary ostium 226 is also controlled by controlling the size of the passageway or constriction at or near the leading (LV)end 105. If the flow rate through the passageway at the trailing (RA) end 109 into the right atrium is too great, the heart tissue would not adequately be perfused and there would be a large left-to-right shunt. If, however, the size of the passageway at the trailing (RA)end 109 is too small, pressure build up within thecoronary sinus 218 would damage the venous system being perfused retrogradely. Preferably, the pressure within the coronary sinus should not exceed a suitable pressure range to avoid damage to the coronary sinus venous system. For example, the pressure should not exceed approximately 50 mm Hg. Thus, the passageway at the trailing (RA) end 109 should be large enough to prevent excess pressure build up, but restrictive enough to allow the heart to be supplied with oxygenated blood. - Coronary sinus pressure may also be controlled by controlling the amount of blood flowing from the
left ventricle 202 into thecoronary sinus 218. Thus, the size of the passageway at the leading (LV) end 105 may be controlled in relation to the size of the passageway at the trailing (RA) end 109 to provide efficient retrograde perfusion of heart tissue without excessive pressure build up. - In an alternative embodiment, as seen in FIG. 4, the smallest diameters or constrictions of the
stent 501 are not at the leading (LV)end 505 and the trailing (RA)end 509, but preferably approximately 5 mm to about 2 cm from the leading (LV)end 505 and the trailing (RA)end 509. Thus, the stent would have one or two flaring ends. The smallest cross sectional areas would be atconstrictions end 505 and the trailing (RA)end 509, respectively. - In some embodiments, a stent having a constant cross sectional area throughout its length is constricted at or near the ends so that the cross sectional areas at the constrictions are limited. Such constrictions may be woven into the stent design or applied by constricting material or other materials and/or mean as known in the art, e.g., using suture, band, wire, or tape. In other embodiments, the cover itself may limit the cross sectional area of the stent.
Claims (31)
1. A stent for supplying oxygenated blood to heart tissue retrogradely through the coronary sinus comprising:
a tubular member having a leading end and a trailing end and a passageway therethrough,
said tubular member having one or more interstices therein,
said tubular member having a constriction at or near the leading end and a constriction at or near the trailing end, and
said tubular member surrounded by a cover at or near the trailing end.
2. The stent according to claim 1 , wherein the cross sectional area of the constriction at or near the trailing end controls the amount of blood flow into the right atrium.
3. The stent according to claim 1 , wherein the cross sectional area of the constriction at or near the trailing end provides retrograde perfusion while maintaining an appropriate pressure within the coronary sinus
4. The stent of claim 3 , wherein said appropriate pressure is approximately 50 mm Hg.
5. The stent according to claim 1 , wherein the diameter of the constriction at or near the trailing end is from about 1 mm to about 6 mm.
6. The stent according to claim 1 , wherein the diameter of the constriction at or near the trailing end is from about 2 mm to about 4 mm.
7. The stent according to claim 1 , wherein the cross sectional area of the constriction at or near the leading end controls the amount of blood flowing into the stent.
8. The stent according to claim 1 , wherein the diameter of the constriction at or near the leading end is from about 1 mm to about 6 mm.
9. The stent according to claim 1 , wherein the diameter of the constriction at or near the leading end is from about 2 mm to about 5 mm.
10. The stent according to claim 1 , wherein the diameter of the constrictions at or near the leading and the trailing ends are from about 1 mm to about 6 mm.
11. The stent according to claim 1 , wherein the diameter of the constrictions at or near the leading and the trailing ends are from about 2 mm to about 5 mm.
12. The stent according to claim 1 , wherein said tubular member expands cross sectionally.
13. The stent according to claim 12 , wherein said tubular member compresses cross sectionally.
14. The stent according to claim 1 , wherein said tubular member is flexible to allow bending.
15. The stent according to claim 1 , wherein said stent has a mesh construction.
16. The stent according to claim 1 , wherein said stent has a coiled construction.
17. The stent according to claim 1 , wherein the diameter of the stent does not exceed from about 6 mm to about 15 mm.
18. The stent according to claim 1 , wherein said cover surrounds from about 0.5 cm to about 4 cm of the tubular member at or near the trailing end.
19. The stent according to claim 1 , wherein said cover surrounds from about 1 cm to about 3 cm of the tubular member at or near the trailing end.
20. The stent according to claim 1 , wherein said stent has a cover surrounding the tubular member at or near the leading end.
21. The stent according to claim 20 , wherein said cover surrounds from about 0.5 cm to about 4 cm of the tubular member at or near the leading end.
22. The stent according to claim 1 , wherein said tubular member exhibits said constrictions when expanded without additional mechanism or means.
23. The stent according to claim 22 , wherein said constrictions are woven into the tubular member.
24. The stent according to claim 1 , wherein said constrictions are applied by a constricting material.
25. The stent according to claim 1 , wherein said constrictions are applied by a constricting means.
26. A method for directly supply oxygenated blood from the left ventricle to heart tissue via the coronary sinus using a stent comprising:
a tubular member having a leading end and a trailing end and a passageway therethrough,
said tubular member having one or more interstices therein,
said tubular member having a constriction at or near the leading end and a constriction at or near the trailing end, and
said tubular member surrounded by a cover at or near the trailing end.
27. The method according to claim 26 , wherein said stent maintains an appropriate pressure in the coronary sinus.
28. The method according to claim 26 , wherein said tubular member is positioned substantially within the coronary sinus.
29. The method according to claim 26 , wherein the leading end protrudes into the left ventricle.
30. The method according to claim 26 , wherein the trailing end protrudes into the right atrium.
31. A method for directly supplying oxygenated blood from the left ventricle to heart tissue via the coronary sinus using the stent of claim 1 comprising:
creating a hole with the wall of the coronary sinus and the wall of the left ventricle to make an opening between the left ventricle and the coronary sinus, dilating the hole, percutaneously delivering and positioning the stent to provide a fluid passageway between the left ventricle and the coronary sinus.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US10/365,458 US20030125798A1 (en) | 2001-03-02 | 2003-02-13 | Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US09/796,528 US6562066B1 (en) | 2001-03-02 | 2001-03-02 | Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium |
US10/365,458 US20030125798A1 (en) | 2001-03-02 | 2003-02-13 | Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium |
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US09/796,528 Continuation-In-Part US6562066B1 (en) | 2001-03-02 | 2001-03-02 | Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium |
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US10/365,458 Abandoned US20030125798A1 (en) | 2001-03-02 | 2003-02-13 | Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium |
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Also Published As
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AU2002244193A1 (en) | 2002-09-24 |
WO2002071974A2 (en) | 2002-09-19 |
US6562066B1 (en) | 2003-05-13 |
WO2002071974A3 (en) | 2002-11-14 |
DE10296426T5 (en) | 2004-04-15 |
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