US20020072681A1 - Pressure applicator devices particularly useful for non-invasive detection of medical conditions - Google Patents

Pressure applicator devices particularly useful for non-invasive detection of medical conditions Download PDF

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Publication number
US20020072681A1
US20020072681A1 US10/073,342 US7334202A US2002072681A1 US 20020072681 A1 US20020072681 A1 US 20020072681A1 US 7334202 A US7334202 A US 7334202A US 2002072681 A1 US2002072681 A1 US 2002072681A1
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Prior art keywords
housing
patient
body part
membrane
chamber
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US10/073,342
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Robert Schnali
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Itamar Medical Ltd
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Itamar Medical Ltd
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Priority to US10/073,342 priority Critical patent/US20020072681A1/en
Publication of US20020072681A1 publication Critical patent/US20020072681A1/en
Priority to US10/851,137 priority patent/US6916289B2/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6825Hand
    • A61B5/6826Finger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007Evaluating blood vessel condition, e.g. elasticity, compliance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1073Measuring volume, e.g. of limbs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683Means for maintaining contact with the body
    • A61B5/6838Clamps or clips

Definitions

  • the present invention relates to pressure applicator devices for applying a predetermined static pressure to a body part of a patient.
  • the invention is particularly useful as a probe for application to a digit (i.e., a finger or toe) of a patient for the non-invasive detection of certain medical conditions in accordance with the method described in our PCT Application PCT/IL97/00249; and the invention is therefore described below especially with respect to such applications.
  • the described apparatus includes a probe for application to the patient's body part (e.g., finger) which probe includes a housing for receiving the distal end of the patient's body part, and pressurizing means for applying a static pressure field substantially uniformly around the distal end of the patient's body part when received in the compartment, including its terminal-most extremity.
  • the static pressure field is of a predetermined magnitude sufficient to substantially prevent distention of the venous vasculature, uncontrolled venous backflow, and retrograde shockwave propagation into the distal end of the body part, and to partially unload the wall tension of, but not to occlude, the arteries in the distal end of the body part when at heart level or below.
  • the probe further includes a sensor within the housing for sensing changes in-the distal end of the patient's body part related to changes in volume therein due to changes in instantaneous blood volume related to arterial tone.
  • An object of the present invention is to provide a device particularly useful as a probe in the method and apparatus of the above-cited PCT Application but of a simplified or improved construction as compared to the devices described therein. Another object is to provide a probe which does not restrict the mobility of the patient.
  • a device for application to a digit of a patient to detect a change in the physical condition of the patient comprising a probe including: a housing defining a compartment closed at one end and open at the opposite end for receiving the distal end of the patient's body part; pressurizing means for applying a static pressure field substantially uniformly around the distal end of the patient's body part, when received in the compartment, including the extreme distal tip of the patient's body part, which static pressure field is of a predetermined magnitude sufficient to substantially prevent distention of the venous vasculature, uncontrolled venous backflow, and retrograde venous shockwave propagation into the distal end, and to partially unload the wall tension of, but not to occlude, the arteries in the distal end when at heart level or below; and a sensor for sensing changes in the distal end of the patient's body part related to changes in volume thereof due to changes in instantaneous blood volume related to arterial blood
  • the pressurizing means includes an inner resilient membrane within the housing and defining therewith an inner chamber to be filled with a fluid for applying the static pressure via the membrane substantially uniformly around the distal end of the patient's body part, including its terminal-most extremity.
  • the pressurizing means further includes an outer resilient membrane attached to the housing externally thereof and defining therewith an outer chamber communicating with the inner chamber via openings in the housing for enlarging the effective volume of the inner chamber such as to cause the inner membrane to apply substantially the same static pressure around the distal end of the patient's body part despite changes in volume therein.
  • the pressure means includes a body of resilient sponge material formed with a recess defining the compartment for receiving the patient's body part when inserted therein.
  • the sensor within the housing is described below, for purposes of example, as being either an optical sensor for optically detecting, or a Hall Effect sensor for magnetically detecting, volume changes in the subject's finger which attend pulse-related blood volume changes and corresponding finger girth changes.
  • the present invention enables probes to be constructed with the static pressurizing means wholly self-contained within the probe housing, thereby greatly simplifying the construction of the probe as well as reducing restrictions on the mobility of the patient using such a probe.
  • the invention may also be implemented in a two-section probe wherein one section includes a first housing attached to the body part and defining a part of the static pressurizing means, and the second section includes a second housing having another part of the static pressurizing means in fluid connection to the first section, the sensor being located within the second section.
  • FIG. 1 is a longitudinal sectional view
  • FIG. 1 a is a corresponding view but rotated 90° with respect to FIG. 1, illustrating one form of finger probe constructed in accordance with the present invention
  • FIG. 2 is a graph of volume versus pressure
  • FIG. 3 is a graph of pressure versus time, both helpful in explaining the operation of the finger probe of FIG. 1;
  • FIG. 4 is a view similar to that of FIG. 1, but omitting the sensor and illustrating a modification in the construction of-the finger probe;
  • FIG. 5 is a view similar to that of FIG. 1, but illustrating another finger probe constructed in accordance with the present invention
  • FIGS. 6 a - 6 c diagrammatically illustrate one manner of applying the probe of FIG. 5 to a patient's finger
  • FIGS. 7 a - 7 c illustrate a modification in the construction of the probe of FIG. 5, and the manner of applying it to the patient's finger;
  • FIGS. 8 a - 8 c diagrammatically illustrate another probe constructed in accordance with the present invention.
  • FIG. 9 is a side elevational view diagrammatically illustrating a probe similar to that of FIGS. 8 a - 8 c but including another fastening arrangement for fastening the two half-sections together;
  • FIGS. 10 a - 10 c are views corresponding to FIGS. 8 a - 8 c but illustrating another probe constructed in accordance with the present invention
  • FIGS. 11 a - 11 c illustrate another probe construction similar to that of FIGS. 10 a - 10 c;
  • FIG. 12 illustrates one manner of applying to a patient the probe of FIGS. 11 a - 11 c and a read-out to an electrical circuit
  • FIGS. 13 a - 13 c diagrammatically illustrate another probe construction in accordance with the invention and showing particularly the elements of the sensor and the manner of making electrical connections to them;
  • FIG. 14 illustrates a probe similar to that of FIG. 1 or 4 but including a pressure cuff contiguous to the inner (proximal) end of the probe for extending the pressure field with respect to the sensor elements;
  • FIG. 15 illustrates another construction of a probe in accordance with another aspect of the invention.
  • FIG. 15 a illustrates an overall apparatus including the probe of FIG. 15;
  • FIGS. 16 and 16 a diagrammatically illustrate another probe construction in accordance with the present invention.
  • FIG. 17 illustrates an overall apparatus including any of the other described probes
  • FIGS. 18 a - 18 d diagrammatically illustrate a further probe construction in accordance with the present invention.
  • FIGS. 1 and 1 a illustrate one form of probe constructed in accordance with the present invention particularly for use in the method and apparatus of the above-cited PCT Application for monitoring the peripheral arterial tone of a patient's body part (e.g., digit) in order to indicate, in a non-invasive manner, the physiological state or medical condition of the patient.
  • a patient's body part e.g., digit
  • such a probe includes pressurizing means for applying a static pressure field substantially uniformly around the distal end of the patient's digit, including its terminal-most extremity (extreme distal tip), and a sensor for sensing changes in the distal end of the patient's digit related to changes in volume thereof due to changes in instantaneous blood volume related to arterial blood volume therein.
  • the probe illustrated in FIG. 1 is of a simplified construction as compared to the probes illustrated in the above-cited PCT Application, since the static pressure means in the probe of FIG. 1 is constituted of a medium wholly contained within the probe.
  • the probe illustrated in FIGS. 1 and 1 a includes a housing 2 of rigid plastic material, closed at one end, and open at the opposite end, and defining a compartment for receiving the patient's finger 3 .
  • An inner membrane 4 within housing 2 defines therewith a chamber 5 for receiving a fluid, such as air, which applies a static pressure field substantially uniformly around the distal end of the finger 3 including its extreme distal tip.
  • the probe illustrated in FIGS. 1 and 1 a further includes a sensor constituted of one part 6 a on one side of the finger, and another part 6 b on the opposite side, for measuring changes in volume of the patient's finger caused by arterial blood flow.
  • the illustrated probe further includes a U-shaped restraining bar 7 fixed by an annular ring 8 within the housing to cause the inner membrane 4 to more firmly grip the patient's finger 3 when inserted into the probe.
  • the probe illustrated in FIGS. 1 and 1 a differs from those described in the above-cited PCT Patent Application in the manner of providing the substantially uniform static pressure applied around the digital end of the patient's finger.
  • a static pressure is provided by a remotely-located pressure source coupled by tubing to the probe
  • the probe illustrated in FIGS. 1 and 1 a includes a static pressurizing means which is wholly self-contained within the probe housing.
  • the probe illustrated in FIGS. 1 and 1 a includes an outer resilient membrane 10 attached to the housing 2 externally thereof and defining with the housing an outer chamber 11 .
  • the outer membrane 10 is of annular configuration and is applied around an annular portion of the housing spaced from its tip such that the outer chamber 11 is of annular configuration.
  • the outer annular chamber 11 communicates with the inner chamber 5 by means of a plurality of openings 12 formed through housing 2 .
  • the outer membrane 10 enlarges the effective volume of the inner chamber 5 such as to cause, according to the Laplace Law, the inner membrane 4 to apply substantially the same static pressure around the distal end of the patient's finger 3 despite changes in volume in chamber 5 .
  • FIG. 2 illustrates the relationship of pressure with respect to volume and particularly shows the relatively large operating zone in which the pressure remains substantially constant with the changes in volume.
  • the actual pressure value is a function of the thickness and mechanical characteristics of the distensible material.
  • the probe illustrated in FIGS. 1 and 1 a effectively enlarges the volume of the inner chamber 5 by the volume of the outer chamber 11 communicating with the inner chamber via openings 12 in the housing 2 such that the static pressure applied by the fluid within chamber 5 remains substantially constant irrespective of changes in volume of chamber 5 caused by arterial blood flow within the patient's finger 3 received within the probe. If the finger is partially removed from within the probe, the remaining portion will still be subject to the same external pressure because of the Laplace Effect.
  • FIGS. 1 and 1 a the inner chamber 5 is initially filled with the fluid via a port 13 having a one-way valve 14 permitting the fluid (e.g., air) to flow into the chamber, but not out of the chamber.
  • FIG. 3 illustrates how the pressure varies with time, and shows that after a fixed quantity of air has been added, the pressure within the device remains relatively constant over a 24-hour period.
  • FIG. 4 illustrates a probe of the same construction as described above with respect to FIGS. 1 and 1 a , except that the sensor elements have been omitted for simplification puproses. Also, the port 13 and the one-way valve 14 have been omitted, and instead a fixed volume of fluid is permanently confined within the space defined by the internal membrane 4 and the external membrane 10 .
  • FIG. 5 illustrates a probe of similar construction as FIG. 4, except that the outer membrane 20 is of tubular configuration to define an outer chamber 21 with the distal tip of housing 2 .
  • the outer chamber 21 communicates with the inner chamber 5 via openings 22 formed in the housing tip, so as to effectively enlarge the volume of the inner chamber 5 to produce the relatively constant static pressure applied to the subject's finger 3 irrespective of changes in volume, as described above.
  • FIG. 5 does not include the refill port or one-way valve, corresponding to elements 13 and 14 in FIGS. 1 and 1 a , these elements could be included in which case they would be provided in the portion of housing 3 not covered by the outer membrane 21 .
  • FIGS. 6 a - 6 c illustrate one manner in which the probe constructed as in FIG. 5 may be manipulated to allow the patient's finger 3 to be inserted into the probe.
  • housing 2 of the probe is provided with an annular ring 23 on the rigid portion of the housing spaced inwardly (proximally) from the outer membrane 20 .
  • a syringe including a cylinder 24 and a plunger 25 is used for shifting the fluid from the inner chamber 5 to the outer chamber 21 in order to permit the patient to insert the finger into the probe.
  • FIG. 6 a shows the open end of cylinder 24 applied to ring 23 ;
  • FIG. 6 b shows the plunger 25 being retracted within its cylinder 24 , to thereby draw the fluid within the inner chamber 5 into the outer chamber 21 , permitting the subject to insert the finger into the probe, whereupon the plunger 25 may be returned to its normal position within its cylinder 24 ; and FIG. 6 c shows the syringe being removed.
  • FIGS. 7 a - 7 c illustrate another manner of manipulating the probe of FIG. 5 to permit insertion of the subject's finger. This is done by providing the outer membrane 20 with a finger piece including a knob 26 externally of the membrane and fixed to a backing member 28 engageing the inner surface of the membrane. Thus, knob 26 may be grasped by the user and pulled outwardly (FIG. 7 b ) to expand the outer chamber 21 , thereby to draw into it the fluid from the inner chamber and to permit the patient to insert the finger 3 into the probe. After the patient's finger has thus been inserted, knob 26 may be released, whereupon the probe will assume the operative position illustrated in FIG. 7 c.
  • the function of the outer membrane 20 in the construction of FIGS. 7 a - 7 c is to facilitate the Laplace behavior as in the previously described designs.
  • FIGS. 8 a - 8 c diagrammatically illustrate a probe made of two sections hinged together to enable the probe to be opened (FIG. 8 b ) and closed around the patient's finger (FIG. 8 c ).
  • the housing generally designated 32
  • housing 32 is also of tubular configuration closed at one end and open at the opposite end for the insertion of the finger 33 .
  • housing 32 is split into two half-sections 32 a , 32 b joined together along their length by an integral hinge 32 c .
  • Each housing section 32 a , 32 b includes an inner membrane strip 34 a , 34 b joined along the sides and end wall of the respective tubular section to define two internal chambers 35 a , 35 b .
  • the probe further includes an outer membrane 36 a , 36 b for each housing section 32 a , 32 b attached to the outer surface of the respective housing section to define the two outer chambers 37 a , 37 b communicating with the two inner chambers 35 a , 35 b via openings 38 in the housing sections.
  • the non-hinged sides of the two housing sections carry “Velcro” (T.M.) loop and hook fastener strips 39 a , 39 b , to enable the two sections to be tightly closed around the patient's finger 33 to apply the desired pressure thereto.
  • “Velcro” T.M.
  • FIG. 9 illustrates a two-section construction similar to that of FIGS. 8 a - 8 c , except that, instead of using “Velcro” (T.M.) fastener strips 39 a , 39 b to fasten the two sections together, the fastening elements in the construction illustrated in FIG. 9 include tongues 40 a received within slots 40 b integrally formed in the contacting edges of the two housing sections 32 a , 32 b.
  • Velcro T.M.
  • FIGS. 10 a - 10 c illustrate another two-section probe construction, but in this case the two half-sections 42 a , 42 b are hinged together at the adjacent edges of the two end walls 43 a , 43 b of each housing section.
  • the hinge is in the form of a flexible non-extensible strip 44 bonded to the two end walls 43 a , 43 b .
  • the two half sections are secured in their closed conditions by two “Velcro” (T.M.) strips 45 a , 45 b fixed to one of the housing sections 42 a at the open end of the housing and engageable with strips 46 fixed to the other housing section 42 b .
  • T.M. Two “Velcro”
  • the construction of the probe illustarted in FIGS. 10 a - 10 c is substantially the same as described above and includes the outer membrane defining the outer chamber communicating with the inner chamber to provide the above-described Laplace behavior.
  • FIGS. 11 a - 11 c and 12 illustrate a probe 50 mounted on the finger of a hand 51 (FIG. 12).
  • Probe 50 is of the two-section construction as in FIGS. 10 a - 10 c , and as more particularly illustrated in FIGS. 11 a - 11 c .
  • the latter figures also illustrate the two-section inner membrane 53 a , 53 b defining the two-section inner chamber 54 a , 54 b , and the two-section outer membrane 55 a , 55 b defining the two-section outer chamber 56 a , 56 b communicating with the inner chambers via openings 57 .
  • FIG. 11 a further illustrates the two sensor elements 5 , 8 a , 58 b fixed to the two inner membranes 53 a , 53 b , so as to be located at the opposite sides of the finger when received within the compartment defined by the probe, as shown in FIG. 11 b .
  • the two sensor elements 58 a , 58 b are connected by electrical conductors 59 to an electrical circuit 60 (FIG. 12) fixed to a band 61 , either directly connected, or-by way of a glove.
  • Electrical circuit 60 could include the power supply and other circuitry for driving the sensor elements 58 a , 58 b , for receiving the outputs of those elements, and for storing the outputs, e.g., in a storage device, so as to eliminate the need for external electrical connections when the device is being used.
  • FIG. 11 a further illustrates the provision of a pressure-sensitive switch P, or other pressure sensing device such as a strain gage, on inner membrane 53 b , to ensure that leakage has not occurred, and that the appropriate pressure has been reached, when the probe is applied to the subject's finger.
  • the pressure sensing device could be connected in series with the optical sensor, or in parallel to the control device.
  • FIGS. 4, 7 a - 7 c , 8 a - 8 c , 9 and 10 a - 10 c do not include the sensor elements corresponding to sensor elements 6 a , 6 b of FIGS. 1 and 1 a and sensor elements 58 a , 58 b of FIGS. 11 a - 11 c , it will be appreciated that these are omitted merely for purposes of simplifying the illustration and the description of these probes, and that such probes, when used for the particular applications described above, would also include such sensor elements.
  • the sensor elements in all the described examples could be optical sensors, e.g., a light source (LED) and a light receiver for optically sensing the changes in the finger received within the probe; magnetic sensors, e.g., a permanent magnet and a magnetic field detector for sensing the changes in the finger girth by the Hall Effect; or other types of sensors, such as described in the above-cited PCT Patent Application.
  • optical sensors e.g., a light source (LED) and a light receiver for optically sensing the changes in the finger received within the probe
  • magnetic sensors e.g., a permanent magnet and a magnetic field detector for sensing the changes in the finger girth by the Hall Effect
  • other types of sensors such as described in the above-cited PCT Patent Application.
  • FIGS. 13 a - 13 c illustrate one manner of mounting the sensor elements 58 a , 58 b in the finger probe, and making the external electrical connections to the sensor elements.
  • each sensor element 58 a , 58 b is connected at one end to an electrical conductor 59 a , 59 b , having a rubber plug 62 a , 62 b , at the opposite end, to provide airtight seals in order to preserve the above described Laplace behavior.
  • Plugs 62 a, 62 b are receivable within openings 63 a , 63 b in the walls of the two housing sections 52 a , 52 b hinged together by the strip 44 of flexible non-strechable material.
  • the two sensor elements 58 a , 58 b are fixed to the two diaphragms 53 a , 53 b within the compartment defined by the two housing sections 52 a , 52 b , such that when the sensor elements are assembled, and the two housing sections are in their closed condition as illustrated in FIG. 13 c , the two sensor elements engage the opposite sides of the finger received within the housing compartment.
  • the sensor elements output signals, via the electrical conductors 59 a , 59 b which pass through the housing wall, to the electrical processing and/or storage system, such as the electrical circuit 60 (FIG. 12) on the band 61 of the patient.
  • plug 62 a One of the plugs, e.g., plug 62 a , could be provided with the pressure sensing device P to ensure leakage does not occur, and that the appropriate level of pressure has been reached, when the probe is applied, as described above with respect to FIG. 11 a.
  • FIG. 14 illustrates a finger probe having a thimble section 72 for receiving the end of the patient's finger 73 and an annular pressure cuff 74 contiguous to the open end of the thimble section 72 on the side nearer the heart of the patient when the probe is applied to the patient's finger.
  • a pressure cuff extends the static pressure field past the sensor elements 58 a , 58 b towards the heart side of the patient as described in the above-cited PCT Application.
  • an inner diaphragm 75 is attached around its periphery to the inner surface of the thimble section 72 to define therewith an inner chamber 76 ; and similarly, another inner diaphragm 77 is attached around its periphery to the inner surface of the annular cuff section 74 to define therewith an inner annular chamber 78 .
  • an outer diaphragm 79 is attached along one side of its periphery to the outer surface of the thimble section 72 and along the other side of its periphery to the outer surface of the annular section 74 , to define with both sections a common outer chamber 80 .
  • the outer chamber 80 communicates with inner chamber 76 via openings 81 in the thimble section 72 , and with inner chamber 78 via openings 82 in the annular cuff section 74 .
  • the sensor elements 58 a , 58 b are located within the thimble section 72 .
  • This section applies the static pressure field described earlier substantially uniformly around the distal end of the subject's finger 73 .
  • This static pressure field is extended past the sensor elements towards the heart side of the patient by the inner chamber 78 defined by membrane 77 of the annular cuff section 74 as described in the above-cited PCT Application.
  • the common outer chamber 80 defined by the outer membrane 79 maintains substantially the same static pressure field in both the thimble section 72 and the annular section 74 despite changes in volumes therein, according to the Laplace Law as described above.
  • the sensor elements e.g., 6 a , 6 b in FIGS. 1 a , 1 b
  • the sensor elements are contained within the finger probe so as to be located on opposite sides of the patient's finger when inserted into the probe.
  • the sensor elements generate electrical signals which are outputted via electrical conductors to processing and/or storage circuitry, e.g., electrical conductor 59 and storage circuitry 60 in FIG. 12.
  • FIGS. 15 and 16 illustrate two arrangements wherein the sensor elements are not located in the housing of the finger probe, but rather in another housing separate from the finger probe and connected thereto by fluid tubes.
  • the probe illustrated in FIG. 15 is of the type illustrated in FIG. 14, including a thimble section 72 and an annular cuff section 74 .
  • the inner chamber 76 of the thimble section 72 is connected by a fluid tube 90 to a chamber 92 disposed within a second, rigid housing 93 , which is preferably mounted close to the finger probe, e.g., on the subjects wrist.
  • Chamber 92 is defined by a cylinder 94 closed at one end by an end wall 95 , and at the opposite end by a membrane 96 .
  • Annular chamber 78 of the cuff section 74 is connected via another tube 97 to another chamber 98 within the second housing 93 .
  • Chamber 98 is defined by a cylinder 99 closed at one end 100 and at the opposite end by another membrane 101 .
  • the two chambers 92 and 98 within the second housing 93 will be subject to the same pressures as chamber 76 in the probe thimble section 72 and chamber 78 in the cuff section 74 , respectively. These pressures will be opposed by the pressure within the second housing 93 .
  • the latter pressure may be preset by a syringe 102 including a cylinder 103 coupled to the interior of housing 93 , and a plunger 104 which is movable in order to change the volume, and thereby the pressure, within housing 93 .
  • Chamber 92 connected via tube 90 to the thimble section 72 of the probe, includes the sensor for sensing the volume changes within chamber 76 of the thimble section 72 , and thereby the physical condition of the patient wearing the thimble.
  • one sensor element 105 a is fixed to membrane 96 so as to be displaced with that membrane, whereas the other sensor element 105 b is fixed to the bottom wall 95 of chamber 92 , such that sensor element 105 a will measure the volume changes within chamber 94 .
  • the FIG. 15 arrangement does not provide the advantage of the previously-described arrangements in having the pressurizing means, for applying the static pressure substantially uniformly around the distal end of the patient's digit, to be constituted of a medium wholly self-contained within the finger probe, it does provide a number of other advantages:
  • the thimble section 72 of the probe in FIG. 15 does not require an external chamber, as for example described with respect to FIGS. 1 and 1 a , since chamber 94 within the second housing 93 , if vented to the atmosphere, would act as the external chamber to provide the probe with the above-described Laplacian P/V characteristics.
  • this arrangement enables convenient presetting of the pressures in both the thimble section 72 of the probe, as well as in the annular cuff section 74 .
  • the thimble section of the probe could include two pliable plastic tubular elements each closed at one end and open at the opposite end, and located in the thimble section so as to engage the opposite sides of the patient's finger when inserted therein, such that each such element defines one-half of the pressurizing-chamber.
  • the cuff section 74 could be omitted.
  • housing 93 containing the sensor elements 105 a , 105 b can be located very close to the finger-applied probe, such as on a wrist band (FIG. 12) to minimize the restrictions in the mobility of the patient and also the length of the fluid tubes 90 , 97 .
  • FIG. 15 a illustrates a variation in the construction of the apparatus of FIG. 15, in that the separate housing 93 includes a pressure sensor 105 which senses the pressure within that housing and feeds this information to a CPU 106 the CPU 106 also receives information from the pressure source 107 (e.g., the syringe 102 in FIG. 15) which presets the pressure within housing 93 .
  • the output signals from the sensor elements 105 a , 105 b within housing 93 are also received by CPU 106 after these outputs have been amplified, filtered, and otherwise processed in circuit 108 .
  • the CPU 106 processes the foregoing inputs, e.g., as described in the above-cited PCT Application, and produces an output which is displayed in display 109 .
  • the apparatus illustrated in FIG. 15 is constructed and operates in the same manner as described above with respect to FIG. 15, and therefore includes the same reference numerals identifying the corresponding parts.
  • FIGS. 16 and 16 a illustrate a finger probe of the same construction as described above, particularly as illustrated in FIGS. 15 and 15 a , but including an adhesive layer to be contacted by the patient's finger received within the finger probe.
  • the adhesive layer is provided by a double-sided adhesive strip 107 , including an inner adhesive layer 107 a and an outer adhesive layer 107 b .
  • the inner adhesive layer 107 a is covered by a protective layer 108 which is stripped away, after the finger has been inserted within the probe, to enable the inner adhesive layer 107 a to contact and firmly adhere to the subject's finger when received within the probe.
  • the probe illustrated in FIGS. 16 and 16 a may be of the same construction as described above, particularly with respect to FIGS. 15 and 15 a.
  • FIG. 17 illustrates apparatus including the novel finger probe used in apparatus, similar to that described in FIG. 23 of the above-cited PCT Application, for effecting continuous non-invasive blood pressure measurements.
  • the finger probe illustrated in FIG. 17 is shown as being of the construction described above with respect to FIGS. 11 a - 11 c , although it will be appreciated that it could be of any of the other described constructions.
  • the finger probe illustrated in FIG. 17 includes an electrical heater winding 110 applied around the outer surface of the probe housing 52 a , 52 b for heating the patient's finger within the internal chamber 54 a , 54 b of the probe to any predetermined temperature, preferably 35-40° C.
  • a thermister 111 or the like controls the electrical heater in order to maintain that temperature so as to dilate the blood vessels in the finger.
  • the probe illustrated in FIG. 17 further includes a vertical position sensor 112 for sensing the vertical position of the finger probe with respect to a reference point.
  • Sensor 112 may be of the same construction as described in the above-cited PCT Application, including a housing filled with a liquid (preferably water) closed at one end by a flexible membrane 112 a and connected at its opposite end via a water filled tube 113 to a pressure transducer 114 .
  • Transducer 114 produces an electrical output corresponding to the vertical position of sensor 112 , and thereby of the finger probe, with respect to the subject's heart level.
  • the previously-described sensor elements 58 a , 58 b of the finger probe are connected via electrical conductors 115 to a circuit 115 a for amplifying and processing the output signals, and via an A/D converter 116 , to the CPU 117 .
  • the electrical heater winding 110 is supplied with power via conductors 118 connected to an electrical power supply 119 , also supplying power to the CPU 117 .
  • Thermister 111 is connected via conductors 120 to a control circuit 121 , which also produces an output to the CPU 117 via the A/D converter 116 .
  • CPU 117 produces an output to display 122 .
  • FIGS. 18 a - 18 d illustrate a further finger probe device including a self-contained pressurizing source eliminating the need for fluid connections from the probe to an external source of pressurized fluid.
  • the pressurizing source for applying the static pressure to the patient's finger is not provided by a fluid chamber within the finger probe as in the previously-described embodiments, but rather is provided by a body of resilient sponge material within the finger probe.
  • the finger probe illustrated in FIGS. 18 a - 18 d includes a housing 202 split into two half-sections 202 a , 202 b , hinged together along one side by a flexible, non-extensible strip 203 and containing “Veldro” (T.M.) strips 204 at the opposite side for tightly clamping the probe to the patient's finger 205 according to the static pressure to be applied.
  • the means for applying the static pressure around the patient's finger is in the form of a body of resilient sponge material 206 a , 206 b , carried by each half-section of the probe.
  • a layer of a gel material 207 a , 207 b covers the inner surface of each of the sponge bodies 206 a , 206 b so as to be exposed for direct contact with the patient's finger when inserted into the housing and the housing sections are in their closed condition as illustrated in FIGS. 18 c and 18 d .
  • the sensor elements 208 a , 208 b which may be any of the devices described above, are carried on the inner surfaces of each of the sponge bodies 206 a , 206 b , or their respective gel layers 207 a , 207 b.
  • any desired fixed pressure may be applied to the patient's finger within the probe by applying the Velcro strips with the appropriate tightness to the two housing sections around the patient's finger.
  • the gel layers 207 a , 207 b more securely fix the sponge bodies and their sensor elements to the finger end, and more evenly dissipate the applied force.
  • the finger probe could be used to house a pulse oximeter for measuring the oxygen saturation of blood.
  • conventional pulse-oximeter sensors could be included in the probe housing and would produce a better measurement of the oxygen saturation of the blood (SaO 2 ) because of the stable environment provided by the static pressure field.
  • FIGS. 1 - 17 could be designed to provide the above-described Laplace operation, wherein the distending pressure remains substantially constant irrespective of changes in volume. While the probe construction of FIGS. 18 a - 18 d , including the sponge cushion material, would not operate according to the Laplace law., it will be appreciated that a hybrid construction could be provided, wherein the sponge cushion is included to occupy only a part of the chamber containing the sensors and thereby to provide substantially the Laplace operation.
  • the invention could be used in applications other than finger probes, e.g., as a supplement to a wound dressing for a body part, as a means for producing venous distention in a body part in prepartion for venapuncture, as a means for supporting, decompressing and/or immobilizing soft tissue injuries like sprains in a wrist or ankle, as a pressure applicatior for edematous regions in a body part, and the like.
  • Another possible application of the invention is as a disposable sensor, based on a preinflated surface mounted membrane or membranes, capable of being applied to a finger by being wrapped around the finger and having a free end adhesively closed to impart uniform pressure to the enclosed mass of the finger.
  • the membrane(s) may be mounted on an airtight bendable, but nonstrechable, material such as plastic sheeting, rubberized cloth, or the like.
  • a tube or tubes would communicate between the finger probe and a sensing consol which may be located at the wrist, for example.
  • a unidirectional pressure release valve located at the remote site would ensure that excess pressure is vented from the finger probe upon its initial application.
  • a further possible application of the invention is in a vertical displacement sensor consisting of a single fluid filled tube connected to an atmospheric pressure referenced pressure transducer at one end, and a compliant tip at the opposite end.
  • the pressure transducer and the compliant tip would be respectively situated at heart level and the measurement site, or vice-versa.
  • a still further variation would be to provide the probe with the combination of an optical sensor and a volumetric sensor within the same probe.
  • the optical sensing elements need not be located on opposite sides of the finger as described, but could be at other locations.
  • One particularly useful arrangement is that in which optical sensor ancL light source are respectively placed over the digital arteries, thus being oriented at about 140 degrees with respect to each other.

Abstract

A probe for application to a body part particularly a finger of a patient to detect a change in the physical condition of the patient includes a housing defining a compartment closed at one end and open at the opposite end for receiving the distal end of the patient's finger and means consituted of a medium wholly self-contained within the probe for applying a static pressure field substantially uniformly around the distal end of the patient's finger, of a predetermined magnitude sufficient to substantially prevent distention of the venous vasculature, uncontrolled venous backflow, and retrognade shockwave propagation into the distal end, and to partially unload the wall tension of, but not to occlude, the arteries in the distal end when at heart level or below. A sensor senses changes in the distal end of the patient's finger related to changes in arterial blood volume therein.

Description

    FIELD AND BACKGROUND OF THE INVENTION
  • The present invention relates to pressure applicator devices for applying a predetermined static pressure to a body part of a patient. The invention is particularly useful as a probe for application to a digit (i.e., a finger or toe) of a patient for the non-invasive detection of certain medical conditions in accordance with the method described in our PCT Application PCT/IL97/00249; and the invention is therefore described below especially with respect to such applications. [0001]
  • Our Application PCT/IL97/00249 (WO98/04182, published Feb. 5, 1998) discloses methods and apparatus for the non-invasive detection of a change in a physiological condition of a patient by monitoring changes in the peripheral arterial tone as manifested by changes in the arterial blood volume in a terminal extremity of a body part, preferably a digit (finger or toe) of the patient. The method and apparatus are described in that application particularly for detecting mycardial ischemia and sleep apnea, and also for the continuous monitoring of blood pressure. The described apparatus includes a probe for application to the patient's body part (e.g., finger) which probe includes a housing for receiving the distal end of the patient's body part, and pressurizing means for applying a static pressure field substantially uniformly around the distal end of the patient's body part when received in the compartment, including its terminal-most extremity. The static pressure field is of a predetermined magnitude sufficient to substantially prevent distention of the venous vasculature, uncontrolled venous backflow, and retrograde shockwave propagation into the distal end of the body part, and to partially unload the wall tension of, but not to occlude, the arteries in the distal end of the body part when at heart level or below. The probe further includes a sensor within the housing for sensing changes in-the distal end of the patient's body part related to changes in volume therein due to changes in instantaneous blood volume related to arterial tone. [0002]
  • That application described a number of probe constructions in which the static pressure field was applied via a remotely located pressure source connected by tubing to a fluid chamber within the probe. However, utilizing such remotely-located pressure sources complicates the construction of the apparatus and also restricts the mobility of the patient. [0003]
  • OBJECTS AND BRIEF SUMMARY OF THE PRESENT INVENTION
  • An object of the present invention is to provide a device particularly useful as a probe in the method and apparatus of the above-cited PCT Application but of a simplified or improved construction as compared to the devices described therein. Another object is to provide a probe which does not restrict the mobility of the patient. [0004]
  • According to broad aspect of the present invention, there is provided a device for application to a digit of a patient to detect a change in the physical condition of the patient; the device comprising a probe including: a housing defining a compartment closed at one end and open at the opposite end for receiving the distal end of the patient's body part; pressurizing means for applying a static pressure field substantially uniformly around the distal end of the patient's body part, when received in the compartment, including the extreme distal tip of the patient's body part, which static pressure field is of a predetermined magnitude sufficient to substantially prevent distention of the venous vasculature, uncontrolled venous backflow, and retrograde venous shockwave propagation into the distal end, and to partially unload the wall tension of, but not to occlude, the arteries in the distal end when at heart level or below; and a sensor for sensing changes in the distal end of the patient's body part related to changes in volume thereof due to changes in instantaneous blood volume related to arterial blood volume therein; characterized in that the pressurizing means for applying the static pressure substantially uniformly around the distal end of the patient's body part, including its terminal-most extremity, is constituted of a medium wholly self-contained within the probe. [0005]
  • A number of embodiments are described below for purposes of example. [0006]
  • According to further features in one class of embodiments described below, the pressurizing means includes an inner resilient membrane within the housing and defining therewith an inner chamber to be filled with a fluid for applying the static pressure via the membrane substantially uniformly around the distal end of the patient's body part, including its terminal-most extremity. [0007]
  • According to further features in the latter described embodiments, the pressurizing means further includes an outer resilient membrane attached to the housing externally thereof and defining therewith an outer chamber communicating with the inner chamber via openings in the housing for enlarging the effective volume of the inner chamber such as to cause the inner membrane to apply substantially the same static pressure around the distal end of the patient's body part despite changes in volume therein. [0008]
  • A further embodiment is described below for purposes of example, wherein the pressure means includes a body of resilient sponge material formed with a recess defining the compartment for receiving the patient's body part when inserted therein. [0009]
  • The sensor within the housing is described below, for purposes of example, as being either an optical sensor for optically detecting, or a Hall Effect sensor for magnetically detecting, volume changes in the subject's finger which attend pulse-related blood volume changes and corresponding finger girth changes. [0010]
  • As will be described more particularly below, the present invention enables probes to be constructed with the static pressurizing means wholly self-contained within the probe housing, thereby greatly simplifying the construction of the probe as well as reducing restrictions on the mobility of the patient using such a probe. However, the invention may also be implemented in a two-section probe wherein one section includes a first housing attached to the body part and defining a part of the static pressurizing means, and the second section includes a second housing having another part of the static pressurizing means in fluid connection to the first section, the sensor being located within the second section. [0011]
  • While the invention is particularly useful in the methods and apparatus of the above-cited PCT Application, the invention, or various features thereof, can be used in other applications as will also be described below. [0012]
  • Further features and advantages of the invention will be apparent from the description below.[0013]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The invention is herein described, by way of example only, with reference to the accompanying drawings, wherein: [0014]
  • FIG. 1 is a longitudinal sectional view, and [0015]
  • FIG. 1[0016] a is a corresponding view but rotated 90° with respect to FIG. 1, illustrating one form of finger probe constructed in accordance with the present invention;
  • FIG. 2 is a graph of volume versus pressure, and FIG. 3 is a graph of pressure versus time, both helpful in explaining the operation of the finger probe of FIG. 1; [0017]
  • FIG. 4 is a view similar to that of FIG. 1, but omitting the sensor and illustrating a modification in the construction of-the finger probe; [0018]
  • FIG. 5 is a view similar to that of FIG. 1, but illustrating another finger probe constructed in accordance with the present invention; [0019]
  • FIGS. 6[0020] a-6 c diagrammatically illustrate one manner of applying the probe of FIG. 5 to a patient's finger;
  • FIGS. 7[0021] a-7 c illustrate a modification in the construction of the probe of FIG. 5, and the manner of applying it to the patient's finger;
  • FIGS. 8[0022] a-8 c diagrammatically illustrate another probe constructed in accordance with the present invention;
  • FIG. 9 is a side elevational view diagrammatically illustrating a probe similar to that of FIGS. 8[0023] a-8 c but including another fastening arrangement for fastening the two half-sections together;
  • FIGS. 10[0024] a-10 c are views corresponding to FIGS. 8a-8 c but illustrating another probe constructed in accordance with the present invention;
  • FIGS. 11[0025] a-11 c illustrate another probe construction similar to that of FIGS. 10a-10 c;
  • FIG. 12 illustrates one manner of applying to a patient the probe of FIGS. 11[0026] a-11 c and a read-out to an electrical circuit;
  • FIGS. 13[0027] a-13 c diagrammatically illustrate another probe construction in accordance with the invention and showing particularly the elements of the sensor and the manner of making electrical connections to them;
  • FIG. 14 illustrates a probe similar to that of FIG. 1 or [0028] 4 but including a pressure cuff contiguous to the inner (proximal) end of the probe for extending the pressure field with respect to the sensor elements;
  • FIG. 15 illustrates another construction of a probe in accordance with another aspect of the invention; [0029]
  • FIG. 15[0030] a illustrates an overall apparatus including the probe of FIG. 15;
  • FIGS. 16 and 16[0031] a diagrammatically illustrate another probe construction in accordance with the present invention;
  • FIG. 17 illustrates an overall apparatus including any of the other described probes; [0032]
  • and FIGS. 18[0033] a-18 d diagrammatically illustrate a further probe construction in accordance with the present invention.
  • DESCRIPTION OF PREFERRED EMBODIMENTS
  • FIGS. 1 and 1[0034] a illustrate one form of probe constructed in accordance with the present invention particularly for use in the method and apparatus of the above-cited PCT Application for monitoring the peripheral arterial tone of a patient's body part (e.g., digit) in order to indicate, in a non-invasive manner, the physiological state or medical condition of the patient. As briefly described above, and as more fully described in the above-cited PCT Application, such a probe includes pressurizing means for applying a static pressure field substantially uniformly around the distal end of the patient's digit, including its terminal-most extremity (extreme distal tip), and a sensor for sensing changes in the distal end of the patient's digit related to changes in volume thereof due to changes in instantaneous blood volume related to arterial blood volume therein. The probe illustrated in FIG. 1, however, is of a simplified construction as compared to the probes illustrated in the above-cited PCT Application, since the static pressure means in the probe of FIG. 1 is constituted of a medium wholly contained within the probe.
  • The probe illustrated in FIGS. 1 and 1[0035] a includes a housing 2 of rigid plastic material, closed at one end, and open at the opposite end, and defining a compartment for receiving the patient's finger 3. An inner membrane 4 within housing 2 defines therewith a chamber 5 for receiving a fluid, such as air, which applies a static pressure field substantially uniformly around the distal end of the finger 3 including its extreme distal tip. The probe illustrated in FIGS. 1 and 1a further includes a sensor constituted of one part 6 a on one side of the finger, and another part 6 b on the opposite side, for measuring changes in volume of the patient's finger caused by arterial blood flow. The illustrated probe further includes a U-shaped restraining bar 7 fixed by an annular ring 8 within the housing to cause the inner membrane 4 to more firmly grip the patient's finger 3 when inserted into the probe.
  • The above-cited PCT Application is hereby incorporated by reference for further details of the construction of the probe and the manner of its use for monitoring a physiological state or medical condition of the patient. [0036]
  • The probe illustrated in FIGS. 1 and 1[0037] a, however, differs from those described in the above-cited PCT Patent Application in the manner of providing the substantially uniform static pressure applied around the digital end of the patient's finger. Whereas in the examples illustrated in the above-cited PCT Application, such a static pressure is provided by a remotely-located pressure source coupled by tubing to the probe, the probe illustrated in FIGS. 1 and 1a includes a static pressurizing means which is wholly self-contained within the probe housing.
  • For this purpose, the probe illustrated in FIGS. 1 and 1[0038] a includes an outer resilient membrane 10 attached to the housing 2 externally thereof and defining with the housing an outer chamber 11. The outer membrane 10 is of annular configuration and is applied around an annular portion of the housing spaced from its tip such that the outer chamber 11 is of annular configuration. The outer annular chamber 11 communicates with the inner chamber 5 by means of a plurality of openings 12 formed through housing 2.
  • The [0039] outer membrane 10 enlarges the effective volume of the inner chamber 5 such as to cause, according to the Laplace Law, the inner membrane 4 to apply substantially the same static pressure around the distal end of the patient's finger 3 despite changes in volume in chamber 5. Thus, the Laplace Law broadly states that the distending pressure (P) within a distensible hollow object is equal at equalibrium to the tension in the wall (T) divided by the two principal radii of curvature of the object (R1, R2); that is P=T (1/R1+1/R2). In a sphere, R1=R2; therefore P=2T/R. When the wall tension and the radius vary in direction proportion to each other (i.e., T/R is constant), as is substantially the case for rubber balloons for most of the range above the minimum distention and below the maximum distention, the balloon distending pressure remains substantially constant irrespective of changes in volume.
  • FIG. 2 illustrates the relationship of pressure with respect to volume and particularly shows the relatively large operating zone in which the pressure remains substantially constant with the changes in volume. The actual pressure value is a function of the thickness and mechanical characteristics of the distensible material. [0040]
  • The probe illustrated in FIGS. 1 and 1[0041] a effectively enlarges the volume of the inner chamber 5 by the volume of the outer chamber 11 communicating with the inner chamber via openings 12 in the housing 2 such that the static pressure applied by the fluid within chamber 5 remains substantially constant irrespective of changes in volume of chamber 5 caused by arterial blood flow within the patient's finger 3 received within the probe. If the finger is partially removed from within the probe, the remaining portion will still be subject to the same external pressure because of the Laplace Effect.
  • The application of near diastolic counterpressures (40-70 mmHg), over the entire surface of the distal phalanges of the finger, was found not to adversely affect tissue perfusion despite the knowledge that localized pressure applied to tissues can cause collapse of microcirculation. This is due to the fact that while arterial pressure exceeds the counterpressure permitting inflow of arterial blood, for blood to return via the veins venous pressure must overcome the applied external pressure. The induced elevation of venous pressure causes the upstream microcirculation to be pressurized to a pressure level intermediate between the outgoing venous blood and the incoming arterial blood; hence the transmural pressure of the microcirculation within the applied pressure field is greater than zero and collapse of the microcirculation is prevented. [0042]
  • The maintenance of fingertip surface temperature within a narrow range around 36° C., and the lack of a tendency for surface temperature to fall after 2 hours of 70 mmHg pressure application, supports the above described model of the preservation of microcirculatory patency and consequently adequate tissue perfusion, as does the fact that overnight application of the pressurized probed on over 120 fingers in 60 subjects was well tolerated with no deleterious effects. [0043]
  • In the probe illustrated in FIGS. 1 and 1[0044] a, the inner chamber 5 is initially filled with the fluid via a port 13 having a one-way valve 14 permitting the fluid (e.g., air) to flow into the chamber, but not out of the chamber. FIG. 3 illustrates how the pressure varies with time, and shows that after a fixed quantity of air has been added, the pressure within the device remains relatively constant over a 24-hour period.
  • FIG. 4 illustrates a probe of the same construction as described above with respect to FIGS. 1 and 1[0045] a, except that the sensor elements have been omitted for simplification puproses. Also, the port 13 and the one-way valve 14 have been omitted, and instead a fixed volume of fluid is permanently confined within the space defined by the internal membrane 4 and the external membrane 10.
  • FIG. 5 illustrates a probe of similar construction as FIG. 4, except that the [0046] outer membrane 20 is of tubular configuration to define an outer chamber 21 with the distal tip of housing 2. The outer chamber 21 communicates with the inner chamber 5 via openings 22 formed in the housing tip, so as to effectively enlarge the volume of the inner chamber 5 to produce the relatively constant static pressure applied to the subject's finger 3 irrespective of changes in volume, as described above. Although FIG. 5 does not include the refill port or one-way valve, corresponding to elements 13 and 14 in FIGS. 1 and 1a, these elements could be included in which case they would be provided in the portion of housing 3 not covered by the outer membrane 21.
  • FIGS. 6[0047] a-6 c illustrate one manner in which the probe constructed as in FIG. 5 may be manipulated to allow the patient's finger 3 to be inserted into the probe. For this purpose, housing 2 of the probe is provided with an annular ring 23 on the rigid portion of the housing spaced inwardly (proximally) from the outer membrane 20. A syringe including a cylinder 24 and a plunger 25 is used for shifting the fluid from the inner chamber 5 to the outer chamber 21 in order to permit the patient to insert the finger into the probe. FIG. 6a shows the open end of cylinder 24 applied to ring 23; FIG. 6b, shows the plunger 25 being retracted within its cylinder 24, to thereby draw the fluid within the inner chamber 5 into the outer chamber 21, permitting the subject to insert the finger into the probe, whereupon the plunger 25 may be returned to its normal position within its cylinder 24; and FIG. 6c shows the syringe being removed.
  • FIGS. 7[0048] a-7 c illustrate another manner of manipulating the probe of FIG. 5 to permit insertion of the subject's finger. This is done by providing the outer membrane 20 with a finger piece including a knob 26 externally of the membrane and fixed to a backing member 28 engageing the inner surface of the membrane. Thus, knob 26 may be grasped by the user and pulled outwardly (FIG. 7b) to expand the outer chamber 21, thereby to draw into it the fluid from the inner chamber and to permit the patient to insert the finger 3 into the probe. After the patient's finger has thus been inserted, knob 26 may be released, whereupon the probe will assume the operative position illustrated in FIG. 7c.
  • The function of the [0049] outer membrane 20 in the construction of FIGS. 7a-7 c is to facilitate the Laplace behavior as in the previously described designs.
  • FIGS. 8[0050] a-8 c diagrammatically illustrate a probe made of two sections hinged together to enable the probe to be opened (FIG. 8b) and closed around the patient's finger (FIG. 8c). Thus, as shown in FIG. 8a, the housing, generally designated 32, is also of tubular configuration closed at one end and open at the opposite end for the insertion of the finger 33. In this case, however, housing 32 is split into two half- sections 32 a, 32 b joined together along their length by an integral hinge 32 c. Each housing section 32 a, 32 b includes an inner membrane strip 34 a, 34 b joined along the sides and end wall of the respective tubular section to define two internal chambers 35 a, 35 b. The probe further includes an outer membrane 36 a, 36 b for each housing section 32 a, 32 b attached to the outer surface of the respective housing section to define the two outer chambers 37 a, 37 b communicating with the two inner chambers 35 a, 35 b via openings 38 in the housing sections. The non-hinged sides of the two housing sections carry “Velcro” (T.M.) loop and hook fastener strips 39 a, 39 b, to enable the two sections to be tightly closed around the patient's finger 33 to apply the desired pressure thereto.
  • FIG. 9 illustrates a two-section construction similar to that of FIGS. 8[0051] a-8 c, except that, instead of using “Velcro” (T.M.) fastener strips 39 a, 39 b to fasten the two sections together, the fastening elements in the construction illustrated in FIG. 9 include tongues 40 a received within slots 40 b integrally formed in the contacting edges of the two housing sections 32 a, 32 b.
  • FIGS. 10[0052] a-10 c illustrate another two-section probe construction, but in this case the two half- sections 42 a, 42 b are hinged together at the adjacent edges of the two end walls 43 a, 43 b of each housing section. In addition, instead of using an integral hinge, the hinge is in the form of a flexible non-extensible strip 44 bonded to the two end walls 43 a, 43 b. The two half sections are secured in their closed conditions by two “Velcro” (T.M.) strips 45 a, 45 b fixed to one of the housing sections 42 a at the open end of the housing and engageable with strips 46 fixed to the other housing section 42 b. In all other respects, the construction of the probe illustarted in FIGS. 10a-10 c is substantially the same as described above and includes the outer membrane defining the outer chamber communicating with the inner chamber to provide the above-described Laplace behavior.
  • FIGS. 11[0053] a-11 c and 12 illustrate a probe 50 mounted on the finger of a hand 51 (FIG. 12). Probe 50 is of the two-section construction as in FIGS. 10a-10 c, and as more particularly illustrated in FIGS. 11a-11 c. The latter figures also illustrate the two-section inner membrane 53 a, 53 b defining the two-section inner chamber 54 a, 54 b, and the two-section outer membrane 55 a, 55 b defining the two-section outer chamber 56 a, 56 b communicating with the inner chambers via openings 57.
  • FIG. 11[0054] a further illustrates the two sensor elements 5,8 a, 58 b fixed to the two inner membranes 53 a, 53 b, so as to be located at the opposite sides of the finger when received within the compartment defined by the probe, as shown in FIG. 11b. The two sensor elements 58 a, 58 b are connected by electrical conductors 59 to an electrical circuit 60 (FIG. 12) fixed to a band 61, either directly connected, or-by way of a glove. Electrical circuit 60, for example, could include the power supply and other circuitry for driving the sensor elements 58 a, 58 b, for receiving the outputs of those elements, and for storing the outputs, e.g., in a storage device, so as to eliminate the need for external electrical connections when the device is being used.
  • FIG. 11[0055] a further illustrates the provision of a pressure-sensitive switch P, or other pressure sensing device such as a strain gage, on inner membrane 53 b, to ensure that leakage has not occurred, and that the appropriate pressure has been reached, when the probe is applied to the subject's finger. The pressure sensing device could be connected in series with the optical sensor, or in parallel to the control device.
  • While many of the drawings, such as FIGS. 4, 7[0056] a-7 c, 8 a-8 c, 9 and 10 a-10 c, do not include the sensor elements corresponding to sensor elements 6 a, 6 b of FIGS. 1 and 1a and sensor elements 58 a, 58 b of FIGS. 11a-11 c, it will be appreciated that these are omitted merely for purposes of simplifying the illustration and the description of these probes, and that such probes, when used for the particular applications described above, would also include such sensor elements. As indicated earlier, the sensor elements in all the described examples could be optical sensors, e.g., a light source (LED) and a light receiver for optically sensing the changes in the finger received within the probe; magnetic sensors, e.g., a permanent magnet and a magnetic field detector for sensing the changes in the finger girth by the Hall Effect; or other types of sensors, such as described in the above-cited PCT Patent Application.
  • FIGS. 13[0057] a-13 c illustrate one manner of mounting the sensor elements 58 a, 58 b in the finger probe, and making the external electrical connections to the sensor elements. Thus, each sensor element 58 a, 58 b is connected at one end to an electrical conductor 59 a, 59 b, having a rubber plug 62 a, 62 b, at the opposite end, to provide airtight seals in order to preserve the above described Laplace behavior. Plugs 62 a, 62 b are receivable within openings 63 a, 63 b in the walls of the two housing sections 52 a, 52 b hinged together by the strip 44 of flexible non-strechable material. The two sensor elements 58 a, 58 b are fixed to the two diaphragms 53 a, 53 b within the compartment defined by the two housing sections 52 a, 52 b, such that when the sensor elements are assembled, and the two housing sections are in their closed condition as illustrated in FIG. 13c, the two sensor elements engage the opposite sides of the finger received within the housing compartment. The sensor elements output signals, via the electrical conductors 59 a, 59 b which pass through the housing wall, to the electrical processing and/or storage system, such as the electrical circuit 60 (FIG. 12) on the band 61 of the patient.
  • One of the plugs, e.g., plug [0058] 62 a, could be provided with the pressure sensing device P to ensure leakage does not occur, and that the appropriate level of pressure has been reached, when the probe is applied, as described above with respect to FIG. 11a.
  • FIG. 14 illustrates a finger probe having a [0059] thimble section 72 for receiving the end of the patient's finger 73 and an annular pressure cuff 74 contiguous to the open end of the thimble section 72 on the side nearer the heart of the patient when the probe is applied to the patient's finger. Such a pressure cuff extends the static pressure field past the sensor elements 58 a, 58 b towards the heart side of the patient as described in the above-cited PCT Application. In this case, an inner diaphragm 75 is attached around its periphery to the inner surface of the thimble section 72 to define therewith an inner chamber 76; and similarly, another inner diaphragm 77 is attached around its periphery to the inner surface of the annular cuff section 74 to define therewith an inner annular chamber 78. In addition, an outer diaphragm 79 is attached along one side of its periphery to the outer surface of the thimble section 72 and along the other side of its periphery to the outer surface of the annular section 74, to define with both sections a common outer chamber 80. The outer chamber 80 communicates with inner chamber 76 via openings 81 in the thimble section 72, and with inner chamber 78 via openings 82 in the annular cuff section 74.
  • The [0060] sensor elements 58 a, 58 b are located within the thimble section 72. This section applies the static pressure field described earlier substantially uniformly around the distal end of the subject's finger 73. This static pressure field is extended past the sensor elements towards the heart side of the patient by the inner chamber 78 defined by membrane 77 of the annular cuff section 74 as described in the above-cited PCT Application. In this case, however, the common outer chamber 80 defined by the outer membrane 79 maintains substantially the same static pressure field in both the thimble section 72 and the annular section 74 despite changes in volumes therein, according to the Laplace Law as described above.
  • In the above-described probes, the sensor elements (e.g., [0061] 6 a, 6 b in FIGS. 1a, 1 b) are contained within the finger probe so as to be located on opposite sides of the patient's finger when inserted into the probe. In such arrangements, the sensor elements generate electrical signals which are outputted via electrical conductors to processing and/or storage circuitry, e.g., electrical conductor 59 and storage circuitry 60 in FIG. 12.
  • FIGS. 15 and 16 illustrate two arrangements wherein the sensor elements are not located in the housing of the finger probe, but rather in another housing separate from the finger probe and connected thereto by fluid tubes. [0062]
  • The probe illustrated in FIG. 15 is of the type illustrated in FIG. 14, including a [0063] thimble section 72 and an annular cuff section 74. The inner chamber 76 of the thimble section 72 is connected by a fluid tube 90 to a chamber 92 disposed within a second, rigid housing 93, which is preferably mounted close to the finger probe, e.g., on the subjects wrist. Chamber 92 is defined by a cylinder 94 closed at one end by an end wall 95, and at the opposite end by a membrane 96.
  • [0064] Annular chamber 78 of the cuff section 74 is connected via another tube 97 to another chamber 98 within the second housing 93. Chamber 98 is defined by a cylinder 99 closed at one end 100 and at the opposite end by another membrane 101.
  • It will be seen that the two [0065] chambers 92 and 98 within the second housing 93 will be subject to the same pressures as chamber 76 in the probe thimble section 72 and chamber 78 in the cuff section 74, respectively. These pressures will be opposed by the pressure within the second housing 93. The latter pressure may be preset by a syringe 102 including a cylinder 103 coupled to the interior of housing 93, and a plunger 104 which is movable in order to change the volume, and thereby the pressure, within housing 93.
  • [0066] Chamber 92, connected via tube 90 to the thimble section 72 of the probe, includes the sensor for sensing the volume changes within chamber 76 of the thimble section 72, and thereby the physical condition of the patient wearing the thimble. Thus, one sensor element 105 a is fixed to membrane 96 so as to be displaced with that membrane, whereas the other sensor element 105 b is fixed to the bottom wall 95 of chamber 92, such that sensor element 105 a will measure the volume changes within chamber 94.
  • Although, the FIG. 15 arrangement does not provide the advantage of the previously-described arrangements in having the pressurizing means, for applying the static pressure substantially uniformly around the distal end of the patient's digit, to be constituted of a medium wholly self-contained within the finger probe, it does provide a number of other advantages: Thus, the [0067] thimble section 72 of the probe in FIG. 15 does not require an external chamber, as for example described with respect to FIGS. 1 and 1a, since chamber 94 within the second housing 93, if vented to the atmosphere, would act as the external chamber to provide the probe with the above-described Laplacian P/V characteristics. Also, if the housing is not vented to the atmosphere, this arrangement enables convenient presetting of the pressures in both the thimble section 72 of the probe, as well as in the annular cuff section 74.
  • This arrangement also simplifies the construction of the probe attached to the patient's finger since it locates the sensor elements in the [0068] separate housing 93 rather than in the probe itself. Thus, the thimble section of the probe could include two pliable plastic tubular elements each closed at one end and open at the opposite end, and located in the thimble section so as to engage the opposite sides of the patient's finger when inserted therein, such that each such element defines one-half of the pressurizing-chamber. Also, the cuff section 74 could be omitted.
  • Another possible advantage in the FIG. 15 arrangement is that it tends to avoid local bias towards smaller superficial blood vessels. Also [0069] housing 93 containing the sensor elements 105 a, 105 b, can be located very close to the finger-applied probe, such as on a wrist band (FIG. 12) to minimize the restrictions in the mobility of the patient and also the length of the fluid tubes 90, 97.
  • FIG. 15[0070] a illustrates a variation in the construction of the apparatus of FIG. 15, in that the separate housing 93 includes a pressure sensor 105 which senses the pressure within that housing and feeds this information to a CPU 106 the CPU 106 also receives information from the pressure source 107 (e.g., the syringe 102 in FIG. 15) which presets the pressure within housing 93. The output signals from the sensor elements 105 a, 105 b within housing 93, are also received by CPU 106 after these outputs have been amplified, filtered, and otherwise processed in circuit 108. The CPU 106 processes the foregoing inputs, e.g., as described in the above-cited PCT Application, and produces an output which is displayed in display 109.
  • In all other respects, the apparatus illustrated in FIG. 15 is constructed and operates in the same manner as described above with respect to FIG. 15, and therefore includes the same reference numerals identifying the corresponding parts. [0071]
  • FIGS. 16 and 16[0072] a illustrate a finger probe of the same construction as described above, particularly as illustrated in FIGS. 15 and 15a, but including an adhesive layer to be contacted by the patient's finger received within the finger probe. The adhesive layer is provided by a double-sided adhesive strip 107, including an inner adhesive layer 107 a and an outer adhesive layer 107 b. The inner adhesive layer 107 a is covered by a protective layer 108 which is stripped away, after the finger has been inserted within the probe, to enable the inner adhesive layer 107 a to contact and firmly adhere to the subject's finger when received within the probe.
  • In all other respects, the probe illustrated in FIGS. 16 and 16[0073] a may be of the same construction as described above, particularly with respect to FIGS. 15 and 15a.
  • FIG. 17 illustrates apparatus including the novel finger probe used in apparatus, similar to that described in FIG. 23 of the above-cited PCT Application, for effecting continuous non-invasive blood pressure measurements. For purposes of example, the finger probe illustrated in FIG. 17 is shown as being of the construction described above with respect to FIGS. 11[0074] a-11 c, although it will be appreciated that it could be of any of the other described constructions.
  • Thus, the finger probe illustrated in FIG. 17 includes an electrical heater winding [0075] 110 applied around the outer surface of the probe housing 52 a, 52 b for heating the patient's finger within the internal chamber 54 a, 54 b of the probe to any predetermined temperature, preferably 35-40° C. A thermister 111 or the like controls the electrical heater in order to maintain that temperature so as to dilate the blood vessels in the finger.
  • The probe illustrated in FIG. 17 further includes a [0076] vertical position sensor 112 for sensing the vertical position of the finger probe with respect to a reference point. Sensor 112 may be of the same construction as described in the above-cited PCT Application, including a housing filled with a liquid (preferably water) closed at one end by a flexible membrane 112 a and connected at its opposite end via a water filled tube 113 to a pressure transducer 114. Transducer 114 produces an electrical output corresponding to the vertical position of sensor 112, and thereby of the finger probe, with respect to the subject's heart level.
  • The previously-described [0077] sensor elements 58 a, 58 b of the finger probe are connected via electrical conductors 115 to a circuit 115 a for amplifying and processing the output signals, and via an A/D converter 116, to the CPU 117. The electrical heater winding 110 is supplied with power via conductors 118 connected to an electrical power supply 119, also supplying power to the CPU 117. Thermister 111 is connected via conductors 120 to a control circuit 121, which also produces an output to the CPU 117 via the A/D converter 116. CPU 117 produces an output to display 122.
  • The manner in which the apparatus illustrated in FIG. 17 is calibrated, and then used, for the continuous non-invasive blood pressure measurements is described in the above-cited PCT Application. [0078]
  • FIGS. 18[0079] a-18 d illustrate a further finger probe device including a self-contained pressurizing source eliminating the need for fluid connections from the probe to an external source of pressurized fluid. In the probe illustrated in FIGS. 18a-18 d, however, the pressurizing source for applying the static pressure to the patient's finger is not provided by a fluid chamber within the finger probe as in the previously-described embodiments, but rather is provided by a body of resilient sponge material within the finger probe.
  • Thus, the finger probe illustrated in FIGS. 18[0080] a-18 d includes a housing 202 split into two half- sections 202 a, 202 b, hinged together along one side by a flexible, non-extensible strip 203 and containing “Veldro” (T.M.) strips 204 at the opposite side for tightly clamping the probe to the patient's finger 205 according to the static pressure to be applied. In this case, however, the means for applying the static pressure around the patient's finger is in the form of a body of resilient sponge material 206 a, 206 b, carried by each half-section of the probe. A layer of a gel material 207 a, 207 b, covers the inner surface of each of the sponge bodies 206 a, 206 b so as to be exposed for direct contact with the patient's finger when inserted into the housing and the housing sections are in their closed condition as illustrated in FIGS. 18c and 18 d. The sensor elements 208 a, 208 b, which may be any of the devices described above, are carried on the inner surfaces of each of the sponge bodies 206 a, 206 b, or their respective gel layers 207 a, 207 b.
  • It will be seen that any desired fixed pressure may be applied to the patient's finger within the probe by applying the Velcro strips with the appropriate tightness to the two housing sections around the patient's finger. The gel layers [0081] 207 a, 207 b more securely fix the sponge bodies and their sensor elements to the finger end, and more evenly dissipate the applied force.
  • While the invention has been described with respect to several preferred embodiments, it will be appreciated that these are set forth merely for purposes of example, and that many other variations may be made. For example, other sensors could be used than the optical and Hall-Effect sensors referred to above, e.g., as described in the above-cited PCT Application. Other fasteners than the “Velcro” or other types described above could be used. Also, the probe may be incorporated in a glove to be worn by the subject as also described in the PCT Application. [0082]
  • Further, the finger probe could be used to house a pulse oximeter for measuring the oxygen saturation of blood. In such an application, conventional pulse-oximeter sensors could be included in the probe housing and would produce a better measurement of the oxygen saturation of the blood (SaO[0083] 2) because of the stable environment provided by the static pressure field.
  • It will be appreciated that all the embodiments described with respect to FIGS. [0084] 1-17 could be designed to provide the above-described Laplace operation, wherein the distending pressure remains substantially constant irrespective of changes in volume. While the probe construction of FIGS. 18a-18 d, including the sponge cushion material, would not operate according to the Laplace law., it will be appreciated that a hybrid construction could be provided, wherein the sponge cushion is included to occupy only a part of the chamber containing the sensors and thereby to provide substantially the Laplace operation.
  • In addition, the invention could be used in applications other than finger probes, e.g., as a supplement to a wound dressing for a body part, as a means for producing venous distention in a body part in prepartion for venapuncture, as a means for supporting, decompressing and/or immobilizing soft tissue injuries like sprains in a wrist or ankle, as a pressure applicatior for edematous regions in a body part, and the like. [0085]
  • Another possible application of the invention is as a disposable sensor, based on a preinflated surface mounted membrane or membranes, capable of being applied to a finger by being wrapped around the finger and having a free end adhesively closed to impart uniform pressure to the enclosed mass of the finger. The membrane(s) may be mounted on an airtight bendable, but nonstrechable, material such as plastic sheeting, rubberized cloth, or the like. A tube or tubes would communicate between the finger probe and a sensing consol which may be located at the wrist, for example. A unidirectional pressure release valve located at the remote site would ensure that excess pressure is vented from the finger probe upon its initial application. [0086]
  • A further possible application of the invention is in a vertical displacement sensor consisting of a single fluid filled tube connected to an atmospheric pressure referenced pressure transducer at one end, and a compliant tip at the opposite end. The pressure transducer and the compliant tip would be respectively situated at heart level and the measurement site, or vice-versa. [0087]
  • A still further variation would be to provide the probe with the combination of an optical sensor and a volumetric sensor within the same probe. The optical sensing elements need not be located on opposite sides of the finger as described, but could be at other locations. One particularly useful arrangement is that in which optical sensor ancL light source are respectively placed over the digital arteries, thus being oriented at about 140 degrees with respect to each other. [0088]
  • Many other variations, modifications and applications of the invention will be apparent. [0089]

Claims (47)

What is claimed is:
1. A device for application to a body part of a patient to detect a change in the physical condition of the patient; said device comprising a probe including:
a housing defining a compartment closed at one end and open at the opposite end for receiving the distal end of the patient's body part including its terminal-most extremity;
pressurizing means for applying a static pressure field substantially uniformly around the distal end of the patient's body part, when received in said compartment, including its terminal-most extremity, which static pressure field is of a predetermined magnitude sufficient to substantially prevent distention of the venous vasculature, uncontrolled venous backflow, and retrognade shockwave propogation into said distal end, and to partially unload the wall tension of, but not to occlude, the arteries in said distal end when at heart level or below;
and a sensor for sensing changes in said distal end of the patient's body part related to changes in volume thereof due to changes in instantaneous blood volume related to arterial blood volume therein;
characterized in that said pressurizing means for applying said static pressure substantially uniformly around the distal end of the patient's body part, including its terminal-most extremity, is constituted of a medium wholly self-contained within said probe.
2. The device according to claim 1, wherein said pressurizing means includes an inner resilient membrane within said housing and defining therewith an inner chamber to be filled with a fluid for applying said static pressure via said membrane substantially uniformly around the distal end of the patient's body part including its terminal-most extremity.
3. The device according to claim 2, wherein said pressurizing means further includes an outer resilient membrane attached to said housing externally thereof and defining therewith an outer chamber communicating with said inner chamber via openings in said housing for enlarging the effective volume of said inner chamber such as to cause said inner membrane to apply substantially the same static pressure around the distal end of the patient's body part despite changes in volume thereof.
4. A device to be applied around a body part of a patient, comprising a probe including:
a housing for application to the body part; and
pressurizing means for applying a static pressure field substantially uniformly around the body part; said pressurizing means including:
an inner resilient membrane within said housing and defining therewith an inner chamber to be filled with a fluid for applying said static pressure via said membrane substantially uniformly around the distal end of the patient's digit including its distal tip;
and an outer resilient membrane attached to said housing externally thereof and defining therewith an outer chamber communicating with said inner chamber via openings in said housing for enlarging the effective volume of said inner chamber such as to cause said inner membrane to apply substantially the same static pressure around the body part despite changes in volume thereof.
5. The device according to claim 3, wherein said housing includes a port having a one-way valve for filling said inner chamber to the desired predetermined pressure.
6. The device according to claim 3, wherein said outer resilient membrane is of annular configuration and is applied around an annular portion of the housing formed with said openings providing communication between said inner and outer chambers.
7. The device according to claim 3, wherein said outer resilient membrane is of tubular configuration and is attached around the outer tip of the housing, which tip is formed with said openings providing communication between said inner and outer chambers.
8. The device according to claim 7, wherein said housing includes an annular ring spaced from the outer resilient membrane attached to the housing for receiving the open end of a syringe to be used for enlarging said outer chamber by shifting the fluid from said inner chamber to said outer chamber to facilitate insertion of the patient's body part into said compartment.
9. The device according to claim 7, wherein said outer resilient membrane includes a finger piece graspable by a user for enlarging said outer chamber by shifting the fluid from said inner chamber to said outer chamber to facilitate insertion of the patient's body part into said compartment.
10. The device according to claim 9, wherein said finger piece includes a knob extending externally of the outer membrane for grasping by the user and fixed to a backing member engageable with the inner surface of the outer membrane.
11. The device according to claim 3, wherein said housing is made of two sections hinged together to assume open and closed conditions, and including fastening elements for fastening the two sections in their closed condition.
12. The device according to claim 11, wherein said fastening elements are “Velcro” (T.M.) hook and loop fastener strips carried by the two housing sections.
13. The device according to claim 11, wherein said fastening elements are tongue and recess formations integrally formed in the two housing sections.
14. The device according to claim 11, wherein said housing includes a tubular side wall closed at one end by an end wall and open at the opposite end, said tubular housing being split into two half-sections and hinged together at said end wall.
15. The device according to claim 11, wherein said housing includes a tubular side wall closed at one end by an end wall and open at the opposite end, said housing being split into two half sections and hinged together along said tubular side wall.
16. The device according to claim 14, wherein said hinge is an integral hinge integrally formed with said two half sections of the housing.
17. The device according to claim 14, wherein said hinge is a strip of flexible strechable material attached to the two housing half-sections.
18. The device according to claim 14, wherein:
said inner membrane includes a membrane strip joined to the side wall and end wall of each housing section;
and said outer membrane includes another membrane strip attached to the outer surface of each housing section.
19. The device according to claim 1, wherein said pressurizing means includes an adhesive layer within said compartment to be contacted by the patient's body part received within the device.
20. The device according to claim 19, wherein said adhesive layer is on an inner surface of a plastic strip having an other adhesive layer on its outer surface, said plastic strip further including a protective layer covering said adhesive layer on its inner surface and strippable therefrom to enable said inner surface to contact and firmly adhere to the patient's body part when received within the device.
21. The device according to claim 1, further including an annular pressure cuff applied around the patient's body part contiguous to said housing on the heart side of the patient to extend the static pressure field past the sensor on the heart side of the patient.
22. A device for application to a body part of a patient to detect a change in the physical condition of the patient; said device comprising:
a first housing defining a first compartment closed at one end and open at the opposite end for receiving the distal end of the patient's body part including its terminal-most extremity;
pressurizing means for applying a static pressure field substantially uniformly around the distal end of the patient's body part, when received in said compartment, including its terminal-most extremity, which static pressure field is of a predetermined magnitude sufficient to substantially prevent distention of the venous vasculature, uncontrolled venous backflow, and retrognade shockwave propogation into said distal end, and to partially unload the wall tension of, but not to occlude, the arteries in said distal end when at heart level or below;
a sensor for sensing changes in said distal end of the patient's body part related to changes in volume thereof due to changes in instantaneous blood volume related to arterial blood volume therein;
and a second housing separate and apart from said first housing and defining a second compartment having a fluid connection to said first compartment; said sensor being located within said second housing in operative position with respect to said second compartment.
23. The device according to claim 22, wherein said second housing includes a presettable pressure source for presetting a predetermined pressure in the interior of said second housing.
24. The device according to claim 22, wherein said second housing is vented to the atmosphere.
25. The device according to claim 1, wherein said pressurizing means includes a body of resilient sponge material formed with a recess defining said compartment for receiving the patient's digit when inserted therein.
26. The device according to claim 25, wherein:
said housing is made of two sections hinged together to assume open and closed conditions;
said body of resilient sponge material is also made of two sections, one carried on each section of the housing;
and said housing sections further include fastening elements for fastening the two housing sections in their closed condition.
27. The device according to claim 26, wherein each of said sections of the body of resilient sponge material includes a layer of a gel material exposed for contact with the patient's body part when inserted into the housing and the housing sections are in their closed condition.
28. The device according to claim 1, wherein a pressure sensing device is located within said housing to sense the pressure applied to the patient's body part by said pressurizing means.
29. The device according to claim 1, wherein said sensor is an optical sensor and includes a light source carried within said housing on one side of the patient's body part when inserted therein, and a light detector carried within said housing on the opposite side of the patient's body part.
30. The device according to claim 1, wherein said sensor is a Hall effect sensor and includes a permanent magnet carried within said housing on one side of the patient's body part when inserted therein, and a magnetic field detector carried within said housing on the opposite side of the patient's body part.
31. The device according to claim 1, wherein said sensor includes the combination of an optical sensor device and a volumetric sensing device.
32. The device according to claim 1, wherein said sensor is a pulse oximeter sensor for sensing the oxygen saturation of blood.
33. The device according to claim 1, further including electrical conductors leading from said sensor to an electrical circuit carried by a band applied to another body part of the patient.
34. The device according to claim 33, wherein said electrical circuit includes a storage device for storing the output of said sensor.
35. A device to be applied to a body part of a patient, comprising:
a housing made of two sections hinged together to assume open and closed conditions;
a body of a resilient sponge material divided into two sections, each carried by one of said housing sections, and defining, in the closed condition of the two housing sections, a compartment for receiving the patient's body part;
and fastening elements for fastening the two housing sections in their closed condition.
36. The device according to claim 35, wherein each of said sections of the body of resilient sponge material includes a layer of a gel material exposed for contact with the patient's body part when inserted into the housing and the housing sections are in their closed condition.
37. The device according to claim 35, wherein said fastening elements are “Velcro” (T.M.) hook and loop fastener strips carried by the two housing sections.
38. A device for application to a body part of a patient to detect a change in the physical condition of the patient, said device comprising:
a housing defining a compartment closed at one end and opend at the opposite end for receiving the distal end of the patient's body part;
a first membrane defining a first chamber containing a pressurized fluid to apply a static pressure field to the patient's body part when received within the housing;
a second membrane defining a second chamber communicating with said first chamber and of a volume such that the combined volumes of the two chambers maintain a relatively constant pressure despite changes in volume according to the Laplace Law;
and sensor elements in at least one of said chambers for sensing changes in said distal end of the patient's body part related to changes in volume therein.
39. The device according to claim 38, wherein said second membrane encloses at least a portion of said housing to define said second chamber with the outer surface of the enclosed portion of the housing, said second chamber communicating with said first chamber via openings through said housing.
40. The device according to claim 39, wherein said sensor elements are carried by said first membrane in said first chamber.
41. The device according to claim 39, wherein said second membrane is of annular configuration and is applied around an annular portion of the housing formed with said openings providing communication between said inner and outer chambers.
42. The device according to claim 391 wherein said second membrane is of tubular ocnfiguration and is attached around the outer tip of the housing, which tip is formed with said openings providing communication between said first and second chambers.
43. The device according to claim 38, wherein said second chamber defined by said second membrane is located in a second housing and is connected to said first chamber by a fluid tube.
44. The device according to claim 43, wherein said sensor is Located in said remote housing in operative position with respect to said second chamber.
45. The device according to claim 44, wherein said second membrane is subject to the differential pressure with respect to the pressure in said second chamber and the ambient pressure in said second housing.
46. The device according to claim 45, wherein said second housing includes a pressure presetting device for presetting the pressure within said second housing acting on said second membrane.
47. The device according to claim 46, wherein said remote housing includes a pressure sensor for sensing the ambient pressure within said second housing.
US10/073,342 1998-06-07 2002-02-13 Pressure applicator devices particularly useful for non-invasive detection of medical conditions Abandoned US20020072681A1 (en)

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Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166998A1 (en) * 2002-02-22 2003-09-04 Lowery Guy Russell Preloaded sensor holder
WO2004006748A2 (en) 2002-07-15 2004-01-22 Itamar Medical Ltd. Body surface probe, apparatus and method for non-invasively detecting medical conditions
US20060165596A1 (en) * 2002-08-23 2006-07-27 Nachiket Kharalkar Method and apparatus for noninvasively evaluating endothelial function
US20070016115A1 (en) * 2005-07-04 2007-01-18 Gerhard Buchholtz Shockwave system controlled dependent on patient's blood pressure
US20070073125A1 (en) * 2005-09-29 2007-03-29 Carine Hoarau Medical sensor for reducing motion artifacts and technique for using the same
US20070225614A1 (en) * 2004-05-26 2007-09-27 Endothelix, Inc. Method and apparatus for determining vascular health conditions
US20070225606A1 (en) * 2006-03-22 2007-09-27 Endothelix, Inc. Method and apparatus for comprehensive assessment of vascular health
US20070299328A1 (en) * 1996-10-10 2007-12-27 Nellcor Puritan Bennett Llc Motion compatible sensor for non-invasive optical blood analysis
US20080027330A1 (en) * 2006-05-15 2008-01-31 Endothelix, Inc. Risk assessment method for acute cardiovascular events
US20080076995A1 (en) * 2006-09-22 2008-03-27 Nellcor Puritan Bennett Incorporated Medical sensor for reducing signal artifacts and technique for using the same
US20080081971A1 (en) * 2006-09-29 2008-04-03 Nellcor Puritan Bennett Inc. System and method for preventing sensor misuse
US20080081963A1 (en) * 2006-09-29 2008-04-03 Endothelix, Inc. Methods and Apparatus for Profiling Cardiovascular Vulnerability to Mental Stress
US20080221413A1 (en) * 2007-03-09 2008-09-11 Carine Hoarau Multiple configuration medical sensor and technique for using the same
US20090318819A1 (en) * 2008-06-24 2009-12-24 Nihon Kohden Corporation Pulse photometry probe
US7647084B2 (en) 2005-08-08 2010-01-12 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7657296B2 (en) 2005-08-08 2010-02-02 Nellcor Puritan Bennett Llc Unitary medical sensor assembly and technique for using the same
US7657295B2 (en) 2005-08-08 2010-02-02 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7676253B2 (en) 2005-09-29 2010-03-09 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7796403B2 (en) 2006-09-28 2010-09-14 Nellcor Puritan Bennett Llc Means for mechanical registration and mechanical-electrical coupling of a faraday shield to a photodetector and an electrical circuit
US20100292592A1 (en) * 2009-05-12 2010-11-18 Angiologix Inc. System and method of measuring changes in arterial volume of a limb segment
US20100298717A1 (en) * 2006-02-20 2010-11-25 Alexander Sergeevich Parfyonov Method for non-evasively determining an endothelial function and a device for carrying out said method
US7869849B2 (en) 2006-09-26 2011-01-11 Nellcor Puritan Bennett Llc Opaque, electrically nonconductive region on a medical sensor
US7881762B2 (en) 2005-09-30 2011-02-01 Nellcor Puritan Bennett Llc Clip-style medical sensor and technique for using the same
US7899510B2 (en) 2005-09-29 2011-03-01 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US8073518B2 (en) 2006-05-02 2011-12-06 Nellcor Puritan Bennett Llc Clip-style medical sensor and technique for using the same
US8145288B2 (en) 2006-08-22 2012-03-27 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8175671B2 (en) 2006-09-22 2012-05-08 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8190224B2 (en) 2006-09-22 2012-05-29 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8219170B2 (en) 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US8260391B2 (en) 2005-09-12 2012-09-04 Nellcor Puritan Bennett Llc Medical sensor for reducing motion artifacts and technique for using the same
US8265724B2 (en) 2007-03-09 2012-09-11 Nellcor Puritan Bennett Llc Cancellation of light shunting
US8280469B2 (en) 2007-03-09 2012-10-02 Nellcor Puritan Bennett Llc Method for detection of aberrant tissue spectra
US8315685B2 (en) 2006-09-27 2012-11-20 Nellcor Puritan Bennett Llc Flexible medical sensor enclosure
US8346328B2 (en) 2007-12-21 2013-01-01 Covidien Lp Medical sensor and technique for using the same
US8352009B2 (en) 2005-09-30 2013-01-08 Covidien Lp Medical sensor and technique for using the same
US8352004B2 (en) 2007-12-21 2013-01-08 Covidien Lp Medical sensor and technique for using the same
US8386002B2 (en) 2005-09-30 2013-02-26 Covidien Lp Optically aligned pulse oximetry sensor and technique for using the same
US20130190596A1 (en) * 2012-01-23 2013-07-25 Alexander A. Oraevsky Dynamic Optoacoustic Angiography of Peripheral Vasculature
US20170273433A1 (en) * 2016-03-25 2017-09-28 Casio Computer Co., Ltd. Drawing apparatus, drawing method for drawing apparatus, and computer readable recording medium
US20180000378A1 (en) * 2016-06-30 2018-01-04 General Electric Company Method and apparatus for recording respiratory rate
US10252133B2 (en) * 2012-11-15 2019-04-09 Airborne Athletics, Inc. Sports training machine
US10561219B2 (en) 2016-09-27 2020-02-18 Casio Computer Co., Ltd. Object holding member and drawing apparatus
US11026592B2 (en) * 2017-09-29 2021-06-08 Fitbit, Inc. Finger blood pressure cuff
US11135500B1 (en) 2019-09-11 2021-10-05 Airborne Athletics, Inc. Device for automatic sensing of made and missed sporting attempts
US11246495B2 (en) 2014-10-27 2022-02-15 Vital Sines International Inc. System and method for monitoring aortic pulse wave velocity and blood pressure
US11247109B1 (en) 2016-11-08 2022-02-15 Airborne Athletics, Inc. Basketball training system
US11357412B2 (en) * 2018-11-20 2022-06-14 42 Health Sensor Holdings Ltd. Wearable cardiovascular monitoring device
USD972675S1 (en) 2019-09-06 2022-12-13 Airborne Athletics, Inc. Basketball passing machine

Families Citing this family (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189209B1 (en) 1996-03-29 2007-03-13 Sanuwave, Inc. Method for using acoustic shock waves in the treatment of a diabetic foot ulcer or a pressure sore
US9042952B2 (en) 1997-01-27 2015-05-26 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
US9468378B2 (en) 1997-01-27 2016-10-18 Lawrence A. Lynn Airway instability detection system and method
US8932227B2 (en) 2000-07-28 2015-01-13 Lawrence A. Lynn System and method for CO2 and oximetry integration
US9521971B2 (en) 1997-07-14 2016-12-20 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
US20070191697A1 (en) 2006-02-10 2007-08-16 Lynn Lawrence A System and method for SPO2 instability detection and quantification
IL124787A0 (en) * 1998-06-07 1999-01-26 Itamar Medical C M 1997 Ltd Pressure applicator devices particularly useful for non-invasive detection of medical conditions
US6675031B1 (en) 1999-04-14 2004-01-06 Mallinckrodt Inc. Method and circuit for indicating quality and accuracy of physiological measurements
IL130939A (en) 1999-07-14 2005-11-20 Itamar Medical Ltd Probe devices particularly useful for non-invasivedetection of medical conditions
US6213952B1 (en) * 1999-09-28 2001-04-10 Orsense Ltd. Optical device for non-invasive measurement of blood related signals utilizing a finger holder
US6400971B1 (en) * 1999-10-12 2002-06-04 Orsense Ltd. Optical device for non-invasive measurement of blood-related signals and a finger holder therefor
IL151437A0 (en) 2000-03-02 2003-04-10 Itamar Medical Ltd Method and apparatus for the non-invasive detection of particular sleep-state conditions by monitoring the peripheral vascular system
US7806831B2 (en) 2000-03-02 2010-10-05 Itamar Medical Ltd. Method and apparatus for the non-invasive detection of particular sleep-state conditions by monitoring the peripheral vascular system
US8224412B2 (en) 2000-04-17 2012-07-17 Nellcor Puritan Bennett Llc Pulse oximeter sensor with piece-wise function
EP2684514B1 (en) 2000-04-17 2018-10-24 Covidien LP Pulse oximeter sensor with piece-wise function
US6616624B1 (en) * 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US20060195041A1 (en) 2002-05-17 2006-08-31 Lynn Lawrence A Centralized hospital monitoring system for automatically detecting upper airway instability and for preventing and aborting adverse drug reactions
US9053222B2 (en) 2002-05-17 2015-06-09 Lawrence A. Lynn Patient safety processor
JP4116444B2 (en) * 2001-04-05 2008-07-09 イタマール メディカル リミテッド Non-invasive probe used to detect disease symptoms
US6754516B2 (en) 2001-07-19 2004-06-22 Nellcor Puritan Bennett Incorporated Nuisance alarm reductions in a physiological monitor
US6748254B2 (en) 2001-10-12 2004-06-08 Nellcor Puritan Bennett Incorporated Stacked adhesive optical sensor
KR100434690B1 (en) * 2002-07-19 2004-06-04 소광섭 Apparatus and method for detecting luminescence from biological systems in response to magnetic fields
KR100493157B1 (en) * 2002-08-02 2005-06-03 삼성전자주식회사 Probe using in measuring organism signal and system for measuring organism signal comprising the same
KR20040017378A (en) * 2002-08-21 2004-02-27 주식회사 바이오프로테크 A sensor unit of a instrument for measuring oxygen-saturation
US7289837B2 (en) 2002-10-01 2007-10-30 Nellcor Puritan Bennett Incorpoated Forehead sensor placement
US7698909B2 (en) 2002-10-01 2010-04-20 Nellcor Puritan Bennett Llc Headband with tension indicator
US7190986B1 (en) 2002-10-18 2007-03-13 Nellcor Puritan Bennett Inc. Non-adhesive oximeter sensor for sensitive skin
AU2003276665A1 (en) * 2002-11-06 2004-06-07 Itamar Medical Ltd. Detecting medical conditions with noninvasive body probes
ATE471692T1 (en) * 2002-12-09 2010-07-15 Univ Ramot METHOD FOR DETERMINING ENDOTHELIAL-DEPENDENT VASOACTIVITY
US7006856B2 (en) 2003-01-10 2006-02-28 Nellcor Puritan Bennett Incorporated Signal quality metrics design for qualifying data for a physiological monitor
US7016715B2 (en) 2003-01-13 2006-03-21 Nellcorpuritan Bennett Incorporated Selection of preset filter parameters based on signal quality
EP2465420A3 (en) * 2003-06-03 2012-10-24 Orsense Ltd. Method and system for use in non-invasive optical measurements of blood parameters
US6993372B2 (en) * 2003-06-03 2006-01-31 Orsense Ltd. Method and system for use in non-invasive optical measurements of blood parameters
US7047056B2 (en) 2003-06-25 2006-05-16 Nellcor Puritan Bennett Incorporated Hat-based oximeter sensor
KR100624412B1 (en) * 2003-09-16 2006-09-18 삼성전자주식회사 Blood components measuring apparatus and method of measuring blood components using the same
US8412297B2 (en) 2003-10-01 2013-04-02 Covidien Lp Forehead sensor placement
JP3826938B2 (en) * 2004-02-18 2006-09-27 オムロンヘルスケア株式会社 Sphygmomanometer
US7190985B2 (en) 2004-02-25 2007-03-13 Nellcor Puritan Bennett Inc. Oximeter ambient light cancellation
US7120479B2 (en) 2004-02-25 2006-10-10 Nellcor Puritan Bennett Inc. Switch-mode oximeter LED drive with a single inductor
US7534212B2 (en) 2004-03-08 2009-05-19 Nellcor Puritan Bennett Llc Pulse oximeter with alternate heart-rate determination
US8611977B2 (en) * 2004-03-08 2013-12-17 Covidien Lp Method and apparatus for optical detection of mixed venous and arterial blood pulsation in tissue
US7194293B2 (en) 2004-03-08 2007-03-20 Nellcor Puritan Bennett Incorporated Selection of ensemble averaging weights for a pulse oximeter based on signal quality metrics
US7313425B2 (en) * 2004-07-08 2007-12-25 Orsense Ltd. Device and method for non-invasive optical measurements
EP1793733B1 (en) * 2004-09-15 2017-05-17 Itamar Medical (C.M.) 1997 Ltd. Method and apparatus for non-invasively measuring physiological parameters, particularly blood flow and venous capacitance
JP4460414B2 (en) * 2004-10-06 2010-05-12 日本電信電話株式会社 Sphygmomanometer
US7392075B2 (en) 2005-03-03 2008-06-24 Nellcor Puritan Bennett Incorporated Method for enhancing pulse oximetry calculations in the presence of correlated artifacts
EP1922654B1 (en) 2005-09-26 2020-05-13 Nielsen Media Research, Inc. Methods and apparatus for metering computer-based media presentation
US7725147B2 (en) 2005-09-29 2010-05-25 Nellcor Puritan Bennett Llc System and method for removing artifacts from waveforms
US7725146B2 (en) 2005-09-29 2010-05-25 Nellcor Puritan Bennett Llc System and method for pre-processing waveforms
US8092379B2 (en) 2005-09-29 2012-01-10 Nellcor Puritan Bennett Llc Method and system for determining when to reposition a physiological sensor
US8233954B2 (en) 2005-09-30 2012-07-31 Nellcor Puritan Bennett Llc Mucosal sensor for the assessment of tissue and blood constituents and technique for using the same
US20070106126A1 (en) 2005-09-30 2007-05-10 Mannheimer Paul D Patient monitoring alarm escalation system and method
US7555327B2 (en) 2005-09-30 2009-06-30 Nellcor Puritan Bennett Llc Folding medical sensor and technique for using the same
US8062221B2 (en) 2005-09-30 2011-11-22 Nellcor Puritan Bennett Llc Sensor for tissue gas detection and technique for using the same
US20070100220A1 (en) 2005-10-28 2007-05-03 Baker Clark R Jr Adjusting parameters used in pulse oximetry analysis
US7668579B2 (en) 2006-02-10 2010-02-23 Lynn Lawrence A System and method for the detection of physiologic response to stimulation
US8702606B2 (en) 2006-03-21 2014-04-22 Covidien Lp Patient monitoring help video system and method
US8380271B2 (en) 2006-06-15 2013-02-19 Covidien Lp System and method for generating customizable audible beep tones and alarms
US7890153B2 (en) 2006-09-28 2011-02-15 Nellcor Puritan Bennett Llc System and method for mitigating interference in pulse oximetry
US7680522B2 (en) 2006-09-29 2010-03-16 Nellcor Puritan Bennett Llc Method and apparatus for detecting misapplied sensors
US8068890B2 (en) 2006-09-29 2011-11-29 Nellcor Puritan Bennett Llc Pulse oximetry sensor switchover
US8068891B2 (en) 2006-09-29 2011-11-29 Nellcor Puritan Bennett Llc Symmetric LED array for pulse oximetry
US8728059B2 (en) 2006-09-29 2014-05-20 Covidien Lp System and method for assuring validity of monitoring parameter in combination with a therapeutic device
US8175667B2 (en) 2006-09-29 2012-05-08 Nellcor Puritan Bennett Llc Symmetric LED array for pulse oximetry
US7476131B2 (en) 2006-09-29 2009-01-13 Nellcor Puritan Bennett Llc Device for reducing crosstalk
WO2008078251A1 (en) * 2006-12-21 2008-07-03 Koninklijke Philips Electronics N.V. Wireless interventional device and a system for wireless energy transmission
US8460355B2 (en) * 2007-04-05 2013-06-11 Stryker Corporation Negative/positive pressure, thermal energy therapy device
WO2008131557A1 (en) * 2007-05-01 2008-11-06 Urodynamix Technologies Ltd. Apparatus and methods for evaluating physiological conditions of tissue
JP4982608B2 (en) * 2007-05-02 2012-07-25 プレシジョン・メディカル・デバイスズ・エルエルシー Non-pneumatic tourniquet device
WO2009014420A1 (en) * 2007-07-20 2009-01-29 Bmeye B.V. A method, a system and a computer program product for determining a beat-to beat stroke volume and/or a cardiac output
US20090048649A1 (en) * 2007-08-16 2009-02-19 Gaymar Industries, Inc. Heat transfer device: seal and thermal energy contact units
US8204567B2 (en) 2007-12-13 2012-06-19 Nellcor Puritan Bennett Llc Signal demodulation
US8366613B2 (en) 2007-12-26 2013-02-05 Covidien Lp LED drive circuit for pulse oximetry and method for using same
US8577434B2 (en) 2007-12-27 2013-11-05 Covidien Lp Coaxial LED light sources
US8442608B2 (en) 2007-12-28 2013-05-14 Covidien Lp System and method for estimating physiological parameters by deconvolving artifacts
US8452364B2 (en) 2007-12-28 2013-05-28 Covidien LLP System and method for attaching a sensor to a patient's skin
US8199007B2 (en) 2007-12-31 2012-06-12 Nellcor Puritan Bennett Llc Flex circuit snap track for a biometric sensor
US8092993B2 (en) 2007-12-31 2012-01-10 Nellcor Puritan Bennett Llc Hydrogel thin film for use as a biosensor
US8070508B2 (en) 2007-12-31 2011-12-06 Nellcor Puritan Bennett Llc Method and apparatus for aligning and securing a cable strain relief
US8897850B2 (en) 2007-12-31 2014-11-25 Covidien Lp Sensor with integrated living hinge and spring
US8750953B2 (en) 2008-02-19 2014-06-10 Covidien Lp Methods and systems for alerting practitioners to physiological conditions
US8275553B2 (en) 2008-02-19 2012-09-25 Nellcor Puritan Bennett Llc System and method for evaluating physiological parameter data
KR100978907B1 (en) 2008-03-06 2010-08-31 (주)참케어 Oximeter
US8140272B2 (en) 2008-03-27 2012-03-20 Nellcor Puritan Bennett Llc System and method for unmixing spectroscopic observations with nonnegative matrix factorization
US8437822B2 (en) 2008-03-28 2013-05-07 Covidien Lp System and method for estimating blood analyte concentration
US8112375B2 (en) 2008-03-31 2012-02-07 Nellcor Puritan Bennett Llc Wavelength selection and outlier detection in reduced rank linear models
US8364224B2 (en) 2008-03-31 2013-01-29 Covidien Lp System and method for facilitating sensor and monitor communication
US8292809B2 (en) 2008-03-31 2012-10-23 Nellcor Puritan Bennett Llc Detecting chemical components from spectroscopic observations
EP2283443A1 (en) 2008-05-07 2011-02-16 Lynn, Lawrence A. Medical failure pattern search engine
US9895068B2 (en) 2008-06-30 2018-02-20 Covidien Lp Pulse oximeter with wait-time indication
USD626562S1 (en) 2008-06-30 2010-11-02 Nellcor Puritan Bennett Llc Triangular saturation pattern detection indicator for a patient monitor display panel
US7887345B2 (en) 2008-06-30 2011-02-15 Nellcor Puritan Bennett Llc Single use connector for pulse oximetry sensors
US7880884B2 (en) 2008-06-30 2011-02-01 Nellcor Puritan Bennett Llc System and method for coating and shielding electronic sensor components
US8071935B2 (en) 2008-06-30 2011-12-06 Nellcor Puritan Bennett Llc Optical detector with an overmolded faraday shield
USD626561S1 (en) 2008-06-30 2010-11-02 Nellcor Puritan Bennett Llc Circular satseconds indicator and triangular saturation pattern detection indicator for a patient monitor display panel
US8364220B2 (en) 2008-09-25 2013-01-29 Covidien Lp Medical sensor and technique for using the same
US8257274B2 (en) 2008-09-25 2012-09-04 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US8433382B2 (en) 2008-09-30 2013-04-30 Covidien Lp Transmission mode photon density wave system and method
US8386000B2 (en) 2008-09-30 2013-02-26 Covidien Lp System and method for photon density wave pulse oximetry and pulse hemometry
US8914088B2 (en) 2008-09-30 2014-12-16 Covidien Lp Medical sensor and technique for using the same
US8968193B2 (en) 2008-09-30 2015-03-03 Covidien Lp System and method for enabling a research mode on physiological monitors
US8417309B2 (en) 2008-09-30 2013-04-09 Covidien Lp Medical sensor
US8423112B2 (en) 2008-09-30 2013-04-16 Covidien Lp Medical sensor and technique for using the same
US8052624B2 (en) * 2008-10-29 2011-11-08 Stryker Corporation Negative pressure, thermal energy transfer device that also provides positive pressure to the patient
CA2741044A1 (en) * 2008-10-31 2010-05-06 Nellcor Puritan Bennett Llc System and method for facilitating observation of monitored physiologic data
CA2741026C (en) * 2008-10-31 2015-04-14 Nellcor Puritan Bennett Llc System and method for facilitating observation of monitored physiologic data
US8452366B2 (en) 2009-03-16 2013-05-28 Covidien Lp Medical monitoring device with flexible circuitry
US8515515B2 (en) 2009-03-25 2013-08-20 Covidien Lp Medical sensor with compressible light barrier and technique for using the same
US8221319B2 (en) 2009-03-25 2012-07-17 Nellcor Puritan Bennett Llc Medical device for assessing intravascular blood volume and technique for using the same
US8781548B2 (en) 2009-03-31 2014-07-15 Covidien Lp Medical sensor with flexible components and technique for using the same
US20100249552A1 (en) * 2009-03-31 2010-09-30 Nellcor Puritan Bennett Llc System And Method For Wirelessly Powering Medical Devices
US8509869B2 (en) 2009-05-15 2013-08-13 Covidien Lp Method and apparatus for detecting and analyzing variations in a physiologic parameter
US8634891B2 (en) 2009-05-20 2014-01-21 Covidien Lp Method and system for self regulation of sensor component contact pressure
US9010634B2 (en) 2009-06-30 2015-04-21 Covidien Lp System and method for linking patient data to a patient and providing sensor quality assurance
US8311601B2 (en) 2009-06-30 2012-11-13 Nellcor Puritan Bennett Llc Reflectance and/or transmissive pulse oximeter
US8505821B2 (en) 2009-06-30 2013-08-13 Covidien Lp System and method for providing sensor quality assurance
US8391941B2 (en) 2009-07-17 2013-03-05 Covidien Lp System and method for memory switching for multiple configuration medical sensor
US8494786B2 (en) 2009-07-30 2013-07-23 Covidien Lp Exponential sampling of red and infrared signals
US20110034783A1 (en) * 2009-08-10 2011-02-10 Nellcor Puritan Bennett Llc Systems and methods for balancing power consumption and utility of wireless medical sensors
US8417310B2 (en) 2009-08-10 2013-04-09 Covidien Lp Digital switching in multi-site sensor
US8494606B2 (en) 2009-08-19 2013-07-23 Covidien Lp Photoplethysmography with controlled application of sensor pressure
US8428675B2 (en) 2009-08-19 2013-04-23 Covidien Lp Nanofiber adhesives used in medical devices
DE102009039257A1 (en) * 2009-08-28 2011-03-10 Up Management Gmbh Blood pressure measuring device and method for measuring the blood pressure of a living being
US8998817B2 (en) 2009-08-28 2015-04-07 Up-Med Gmbh Blood pressure measuring device and method for measuring the blood pressure of a living being
US20110276082A1 (en) * 2009-09-17 2011-11-10 Fehring Robert G Device for providing therapeutic pressure therapy to parts of the body for treatment of pain
US8704666B2 (en) 2009-09-21 2014-04-22 Covidien Lp Medical device interface customization systems and methods
US8788001B2 (en) 2009-09-21 2014-07-22 Covidien Lp Time-division multiplexing in a multi-wavelength photon density wave system
US8494604B2 (en) 2009-09-21 2013-07-23 Covidien Lp Wavelength-division multiplexing in a multi-wavelength photon density wave system
US8798704B2 (en) 2009-09-24 2014-08-05 Covidien Lp Photoacoustic spectroscopy method and system to discern sepsis from shock
US8571621B2 (en) * 2009-09-24 2013-10-29 Covidien Lp Minimax filtering for pulse oximetry
US8923945B2 (en) 2009-09-24 2014-12-30 Covidien Lp Determination of a physiological parameter
EP2480997A2 (en) 2009-09-24 2012-08-01 Nellcor Puritan Bennett LLC Determination of a physiological parameter
US8515511B2 (en) 2009-09-29 2013-08-20 Covidien Lp Sensor with an optical coupling material to improve plethysmographic measurements and method of using the same
US9554739B2 (en) * 2009-09-29 2017-01-31 Covidien Lp Smart cable for coupling a medical sensor to an electronic patient monitor
US8376955B2 (en) 2009-09-29 2013-02-19 Covidien Lp Spectroscopic method and system for assessing tissue temperature
US8401608B2 (en) * 2009-09-30 2013-03-19 Covidien Lp Method of analyzing photon density waves in a medical monitor
US9078610B2 (en) * 2010-02-22 2015-07-14 Covidien Lp Motion energy harvesting with wireless sensors
US8874180B2 (en) * 2010-02-28 2014-10-28 Covidien Lp Ambient electromagnetic energy harvesting with wireless sensors
US8483788B2 (en) * 2010-02-28 2013-07-09 Covidien Lp Motion compensation in a sensor
US8553223B2 (en) 2010-03-31 2013-10-08 Covidien Lp Biodegradable fibers for sensing
US8428676B2 (en) 2010-03-31 2013-04-23 Covidien Lp Thermoelectric energy harvesting with wireless sensors
US8391943B2 (en) 2010-03-31 2013-03-05 Covidien Lp Multi-wavelength photon density wave system using an optical switch
US8319401B2 (en) 2010-04-30 2012-11-27 Nellcor Puritan Bennett Llc Air movement energy harvesting with wireless sensors
US8498683B2 (en) 2010-04-30 2013-07-30 Covidien LLP Method for respiration rate and blood pressure alarm management
US9380982B2 (en) 2010-07-28 2016-07-05 Covidien Lp Adaptive alarm system and method
US8930145B2 (en) 2010-07-28 2015-01-06 Covidien Lp Light focusing continuous wave photoacoustic spectroscopy and its applications to patient monitoring
EP2457507B1 (en) * 2010-11-24 2020-01-01 eesy-innovation GmbH Arm band with a recording device for recording a blood count parameter
US8771185B2 (en) * 2010-12-22 2014-07-08 Sleepsafe Drivers, Inc. System and method for reliable sleep diagnostic testing
US8610769B2 (en) 2011-02-28 2013-12-17 Covidien Lp Medical monitor data collection system and method
JP6134729B2 (en) 2011-11-24 2017-05-24 イタマール メディカル リミテッド Device for monitoring arterial pulse waves in diagnosing various medical conditions
CN102525484B (en) * 2012-02-20 2013-06-12 秦皇岛市康泰医学系统有限公司 Digital portable pulse oximeter and battery power supply control method thereof
US9833146B2 (en) 2012-04-17 2017-12-05 Covidien Lp Surgical system and method of use of the same
USD743040S1 (en) * 2014-03-11 2015-11-10 Sonivate Medical, Inc. Wearable ultrasound probe
WO2015153569A1 (en) 2014-03-31 2015-10-08 The Regents Of The University Of Michigan Miniature piezoelectric cardiovascular monitoring system
CN106137161A (en) * 2015-04-07 2016-11-23 刘红超 A kind of heart rate and blood pressure measurement apparatus and method
CN106137163A (en) * 2015-04-07 2016-11-23 刘红超 A kind of heart rate measurement apparatus and method
KR102092864B1 (en) * 2015-08-31 2020-03-24 삼성전자주식회사 A seonsor module and a motion assist apparatus comprising thereof
CN109310347B (en) 2016-06-08 2022-09-20 伊塔玛医疗有限公司 Method and apparatus for non-invasive detection of physiological and pathophysiological sleep conditions
JP6904746B2 (en) * 2017-03-28 2021-07-21 日本光電工業株式会社 Sensor
CN108937896B (en) * 2017-05-23 2021-08-03 深圳先进技术研究院 Central arterial blood pressure measuring method and equipment
IT201900010248A1 (en) 2019-06-27 2020-12-27 Tre Esse Progettazione Biomedica S R L DEVICE FOR THE DETECTION OF VENOUS PRESSURE
US11213227B2 (en) * 2020-04-23 2022-01-04 Murata Vios, Inc. Pulse oximeter
CN115590507B (en) * 2022-12-15 2023-04-18 成都美华优健科技有限责任公司 Multi-position oxyhemoglobin saturation sensor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4685464A (en) * 1985-07-05 1987-08-11 Nellcor Incorporated Durable sensor for detecting optical pulses
US5313940A (en) * 1991-05-15 1994-05-24 Nihon Kohden Corporation Photo-electric pulse wave measuring probe
US5339810A (en) * 1993-05-03 1994-08-23 Marquette Electronics, Inc. Pulse oximetry sensor
US5830136A (en) * 1996-10-31 1998-11-03 Nellcor Puritan Bennett Incorporated Gel pad optical sensor

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2845060A (en) * 1954-04-01 1958-07-29 James A Roman Constant volume pressure pick-up
US3104661A (en) 1959-12-14 1963-09-24 Beckman Instruments Inc System for continuous blood pressure determination
US3156237A (en) * 1963-03-08 1964-11-10 Physio Control Company Inc Apparatus for measuring blood pressure and heartbeat pulses
JPS5033676A (en) 1973-07-30 1975-03-31
US4030485A (en) 1974-11-12 1977-06-21 Glenfield Warner Method and apparatus for continuously monitoring systolic blood pressure
US4067330A (en) * 1976-06-15 1978-01-10 The Raymond Lee Organization, Inc. Bed sore bandage cover
US4112491A (en) 1977-07-05 1978-09-05 Life Sciences, Inc. Direct readout real time physiological parameter analog computer
US4280506A (en) * 1979-05-16 1981-07-28 Hughes Aircraft Company Digital watch/infrared plethysmograph having a removable pulse sensor unit for use with a finger cuff extension
ATE7847T1 (en) 1979-08-28 1984-06-15 Battelle Memorial Institute DEVICE FOR MEASURING HUMAN BLOOD PRESSURE.
NL8005145A (en) 1980-09-12 1982-04-01 Tno DEVICE FOR INDIRECT, NON-INVASIVE, CONTINUOUS MEASUREMENT OF BLOOD PRESSURE.
SE445967B (en) * 1983-10-25 1986-08-04 Romanowski Richard DEVICE FOR ASTAD COMBINING AND MAINTENANCE OF LIQUID AND GAS SAFETY AREAS IN BODY PARTS AND / OR FOR ASTAD COMMUNICATION OF BODIES AND / OR FOR MECHANICAL FIXING OF BODY PARTS
US4677984A (en) 1984-09-24 1987-07-07 Bomed Medical Manufacturing, Ltd. Calibrated arterial pressure measurement device
DE3612532A1 (en) 1985-04-12 1986-10-23 Omron Tateisi Electronics Co., Kyoto ELECTRONIC BLOOD PRESSURE MEASURING DEVICE
US4807639A (en) * 1985-08-31 1989-02-28 Casio Computer Co., Ltd. Pulse detection apparatus
JPS6323645A (en) 1986-05-27 1988-01-30 住友電気工業株式会社 Reflection heating type oxymeter
US4747415A (en) * 1986-06-16 1988-05-31 Pierre Lavoisier Method and device for measuring penile rigidity
US4821734A (en) 1987-04-21 1989-04-18 Nihon Seimitsu Sokki Co., Ltd. Sphygmomanometer
US4846189A (en) 1987-06-29 1989-07-11 Shuxing Sun Noncontactive arterial blood pressure monitor and measuring method
US4836219A (en) 1987-07-08 1989-06-06 President & Fellows Of Harvard College Electronic sleep monitor headgear
DE3810411A1 (en) * 1988-03-26 1989-10-12 Nicolay Gmbh DEVICE FOR FIXING A SENSOR, IN PARTICULAR A SENSOR FOR OXIMETRIC MEASUREMENTS
JPH0288041A (en) * 1988-09-24 1990-03-28 Misawahoomu Sogo Kenkyusho:Kk Finger tip pulse wave sensor
US5237178A (en) * 1990-06-27 1993-08-17 Rosenthal Robert D Non-invasive near-infrared quantitative measurement instrument
US5152296A (en) * 1990-03-01 1992-10-06 Hewlett-Packard Company Dual-finger vital signs monitor
WO1991019451A1 (en) 1990-06-19 1991-12-26 Mitsuei Tomita Device for measuring blood flow velocity and quantity in aorta
DE69119306D1 (en) 1990-07-03 1996-06-13 Ueda Electronic Works Ltd Sphygmomanometer
US5209230A (en) * 1990-10-19 1993-05-11 Nellcor Incorporated Adhesive pulse oximeter sensor with reusable portion
IL100080A (en) 1991-11-19 1994-12-29 Sleep Disorders Diagnostic And Monitor system for determining the sleep stages of a person
CN1078136A (en) * 1992-05-07 1993-11-10 中山医科大学生物医学工程开发中心 A kind of control method of external counterpulsation apparatus
US5365924A (en) 1992-07-31 1994-11-22 Frederick Erdman Association Method and apparatus for non-invasive cardiovascular diagnosis
US5542421A (en) 1992-07-31 1996-08-06 Frederick Erdman Association Method and apparatus for cardiovascular diagnosis
IL107396A (en) * 1992-11-09 1997-02-18 Boehringer Mannheim Gmbh Method and apparatus for analytical determination of glucose in a biological matrix
US5452717A (en) * 1993-07-14 1995-09-26 Masimo Corporation Finger-cot probe
US5337744A (en) 1993-07-14 1994-08-16 Masimo Corporation Low noise finger cot probe
US5438986A (en) 1993-12-14 1995-08-08 Criticare Systems, Inc. Optical sensor
JP3218919B2 (en) * 1995-05-25 2001-10-15 オムロン株式会社 Finger sphygmomanometer
IL120881A (en) * 1996-07-30 2002-09-12 It M R Medic L Cm 1997 Ltd Method and apparatus for the non-invasive continous monitoring of peripheral arterial tone
IL124787A0 (en) * 1998-06-07 1999-01-26 Itamar Medical C M 1997 Ltd Pressure applicator devices particularly useful for non-invasive detection of medical conditions
IL130939A (en) * 1999-07-14 2005-11-20 Itamar Medical Ltd Probe devices particularly useful for non-invasivedetection of medical conditions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4685464A (en) * 1985-07-05 1987-08-11 Nellcor Incorporated Durable sensor for detecting optical pulses
US5313940A (en) * 1991-05-15 1994-05-24 Nihon Kohden Corporation Photo-electric pulse wave measuring probe
US5339810A (en) * 1993-05-03 1994-08-23 Marquette Electronics, Inc. Pulse oximetry sensor
US5830136A (en) * 1996-10-31 1998-11-03 Nellcor Puritan Bennett Incorporated Gel pad optical sensor

Cited By (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8649839B2 (en) 1996-10-10 2014-02-11 Covidien Lp Motion compatible sensor for non-invasive optical blood analysis
US20070299328A1 (en) * 1996-10-10 2007-12-27 Nellcor Puritan Bennett Llc Motion compatible sensor for non-invasive optical blood analysis
US6839585B2 (en) 2002-02-22 2005-01-04 Cybro Medical, Inc. Preloaded sensor holder
US20030166998A1 (en) * 2002-02-22 2003-09-04 Lowery Guy Russell Preloaded sensor holder
US20060064024A1 (en) * 2002-07-15 2006-03-23 Schnall Robert P Body surface probe, apparatus and method for non-invasively detecting medical conditions
US7621877B2 (en) 2002-07-15 2009-11-24 Itamar Medical Ltd. Body surface probe, apparatus and method for non-invasively detecting medical conditions
WO2004006748A2 (en) 2002-07-15 2004-01-22 Itamar Medical Ltd. Body surface probe, apparatus and method for non-invasively detecting medical conditions
US20060165596A1 (en) * 2002-08-23 2006-07-27 Nachiket Kharalkar Method and apparatus for noninvasively evaluating endothelial function
US8551008B2 (en) 2002-08-23 2013-10-08 Morteza Naghavi Method and apparatus for determining vascular health conditions
US20080255471A1 (en) * 2002-08-23 2008-10-16 Endothelix, Inc. Method and apparatus for determining vascular health conditions
US20070225614A1 (en) * 2004-05-26 2007-09-27 Endothelix, Inc. Method and apparatus for determining vascular health conditions
US20070016115A1 (en) * 2005-07-04 2007-01-18 Gerhard Buchholtz Shockwave system controlled dependent on patient's blood pressure
US8002718B2 (en) * 2005-07-04 2011-08-23 Siemens Aktiengesellschaft Shockwave system control dependent on patient's blood pressure
US8528185B2 (en) 2005-08-08 2013-09-10 Covidien Lp Bi-stable medical sensor and technique for using the same
US7738937B2 (en) 2005-08-08 2010-06-15 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7693559B2 (en) 2005-08-08 2010-04-06 Nellcor Puritan Bennett Llc Medical sensor having a deformable region and technique for using the same
US8311602B2 (en) 2005-08-08 2012-11-13 Nellcor Puritan Bennett Llc Compliant diaphragm medical sensor and technique for using the same
US7657295B2 (en) 2005-08-08 2010-02-02 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7684843B2 (en) 2005-08-08 2010-03-23 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7647084B2 (en) 2005-08-08 2010-01-12 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7657294B2 (en) 2005-08-08 2010-02-02 Nellcor Puritan Bennett Llc Compliant diaphragm medical sensor and technique for using the same
US7657296B2 (en) 2005-08-08 2010-02-02 Nellcor Puritan Bennett Llc Unitary medical sensor assembly and technique for using the same
US8260391B2 (en) 2005-09-12 2012-09-04 Nellcor Puritan Bennett Llc Medical sensor for reducing motion artifacts and technique for using the same
US8600469B2 (en) 2005-09-29 2013-12-03 Covidien Lp Medical sensor and technique for using the same
US7650177B2 (en) 2005-09-29 2010-01-19 Nellcor Puritan Bennett Llc Medical sensor for reducing motion artifacts and technique for using the same
US7676253B2 (en) 2005-09-29 2010-03-09 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7904130B2 (en) 2005-09-29 2011-03-08 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US20070073121A1 (en) * 2005-09-29 2007-03-29 Carine Hoarau Medical sensor for reducing motion artifacts and technique for using the same
US7869850B2 (en) 2005-09-29 2011-01-11 Nellcor Puritan Bennett Llc Medical sensor for reducing motion artifacts and technique for using the same
US7729736B2 (en) 2005-09-29 2010-06-01 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US7899510B2 (en) 2005-09-29 2011-03-01 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US20070073125A1 (en) * 2005-09-29 2007-03-29 Carine Hoarau Medical sensor for reducing motion artifacts and technique for using the same
US8965473B2 (en) 2005-09-29 2015-02-24 Covidien Lp Medical sensor for reducing motion artifacts and technique for using the same
US20070073128A1 (en) * 2005-09-29 2007-03-29 Carine Hoarau Medical sensor for reducing motion artifacts and technique for using the same
US8060171B2 (en) 2005-09-29 2011-11-15 Nellcor Puritan Bennett Llc Medical sensor for reducing motion artifacts and technique for using the same
US8352009B2 (en) 2005-09-30 2013-01-08 Covidien Lp Medical sensor and technique for using the same
US7881762B2 (en) 2005-09-30 2011-02-01 Nellcor Puritan Bennett Llc Clip-style medical sensor and technique for using the same
US8386002B2 (en) 2005-09-30 2013-02-26 Covidien Lp Optically aligned pulse oximetry sensor and technique for using the same
US20100298717A1 (en) * 2006-02-20 2010-11-25 Alexander Sergeevich Parfyonov Method for non-evasively determining an endothelial function and a device for carrying out said method
US10238306B2 (en) 2006-02-20 2019-03-26 Everist Genomics, Inc. Method for non-evasively determining an endothelial function and a device for carrying out said method
US20070225606A1 (en) * 2006-03-22 2007-09-27 Endothelix, Inc. Method and apparatus for comprehensive assessment of vascular health
US8437826B2 (en) 2006-05-02 2013-05-07 Covidien Lp Clip-style medical sensor and technique for using the same
US8073518B2 (en) 2006-05-02 2011-12-06 Nellcor Puritan Bennett Llc Clip-style medical sensor and technique for using the same
US20080027330A1 (en) * 2006-05-15 2008-01-31 Endothelix, Inc. Risk assessment method for acute cardiovascular events
US8577436B2 (en) 2006-08-22 2013-11-05 Covidien Lp Medical sensor for reducing signal artifacts and technique for using the same
US8145288B2 (en) 2006-08-22 2012-03-27 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8219170B2 (en) 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US8175671B2 (en) 2006-09-22 2012-05-08 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8396527B2 (en) 2006-09-22 2013-03-12 Covidien Lp Medical sensor for reducing signal artifacts and technique for using the same
US8190225B2 (en) 2006-09-22 2012-05-29 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US20080076995A1 (en) * 2006-09-22 2008-03-27 Nellcor Puritan Bennett Incorporated Medical sensor for reducing signal artifacts and technique for using the same
US8195264B2 (en) 2006-09-22 2012-06-05 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8190224B2 (en) 2006-09-22 2012-05-29 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US7869849B2 (en) 2006-09-26 2011-01-11 Nellcor Puritan Bennett Llc Opaque, electrically nonconductive region on a medical sensor
US8315685B2 (en) 2006-09-27 2012-11-20 Nellcor Puritan Bennett Llc Flexible medical sensor enclosure
US7796403B2 (en) 2006-09-28 2010-09-14 Nellcor Puritan Bennett Llc Means for mechanical registration and mechanical-electrical coupling of a faraday shield to a photodetector and an electrical circuit
US20080081971A1 (en) * 2006-09-29 2008-04-03 Nellcor Puritan Bennett Inc. System and method for preventing sensor misuse
US20080081963A1 (en) * 2006-09-29 2008-04-03 Endothelix, Inc. Methods and Apparatus for Profiling Cardiovascular Vulnerability to Mental Stress
US7684842B2 (en) 2006-09-29 2010-03-23 Nellcor Puritan Bennett Llc System and method for preventing sensor misuse
US8265724B2 (en) 2007-03-09 2012-09-11 Nellcor Puritan Bennett Llc Cancellation of light shunting
US7894869B2 (en) 2007-03-09 2011-02-22 Nellcor Puritan Bennett Llc Multiple configuration medical sensor and technique for using the same
US20080221413A1 (en) * 2007-03-09 2008-09-11 Carine Hoarau Multiple configuration medical sensor and technique for using the same
US8280469B2 (en) 2007-03-09 2012-10-02 Nellcor Puritan Bennett Llc Method for detection of aberrant tissue spectra
US8346328B2 (en) 2007-12-21 2013-01-01 Covidien Lp Medical sensor and technique for using the same
US8352004B2 (en) 2007-12-21 2013-01-08 Covidien Lp Medical sensor and technique for using the same
US20090318819A1 (en) * 2008-06-24 2009-12-24 Nihon Kohden Corporation Pulse photometry probe
US9808166B2 (en) * 2008-06-24 2017-11-07 Nihon Kohden Corporation Pulse photometry probe
US8657755B2 (en) 2009-05-12 2014-02-25 Angiologix, Inc. System and method of measuring changes in arterial volume of a limb segment
US20100292592A1 (en) * 2009-05-12 2010-11-18 Angiologix Inc. System and method of measuring changes in arterial volume of a limb segment
US8057400B2 (en) 2009-05-12 2011-11-15 Angiologix, Inc. System and method of measuring changes in arterial volume of a limb segment
US20130190596A1 (en) * 2012-01-23 2013-07-25 Alexander A. Oraevsky Dynamic Optoacoustic Angiography of Peripheral Vasculature
US10994182B1 (en) 2012-11-15 2021-05-04 Airborne Athletics, Inc. Sports training machine
US11097176B1 (en) 2012-11-15 2021-08-24 Airborne Athletics, Inc. Sports training machine
US10252133B2 (en) * 2012-11-15 2019-04-09 Airborne Athletics, Inc. Sports training machine
US10561916B1 (en) 2012-11-15 2020-02-18 Airborne Athletics, Inc. Sports training machine
US11246495B2 (en) 2014-10-27 2022-02-15 Vital Sines International Inc. System and method for monitoring aortic pulse wave velocity and blood pressure
US20170273433A1 (en) * 2016-03-25 2017-09-28 Casio Computer Co., Ltd. Drawing apparatus, drawing method for drawing apparatus, and computer readable recording medium
US9943155B2 (en) * 2016-03-25 2018-04-17 Casio Computer Co., Ltd. Drawing apparatus, drawing method for drawing apparatus, and computer readable recording medium
US20180000378A1 (en) * 2016-06-30 2018-01-04 General Electric Company Method and apparatus for recording respiratory rate
US10561219B2 (en) 2016-09-27 2020-02-18 Casio Computer Co., Ltd. Object holding member and drawing apparatus
US11247109B1 (en) 2016-11-08 2022-02-15 Airborne Athletics, Inc. Basketball training system
US11491383B1 (en) 2016-11-08 2022-11-08 Airborne Athletics, Inc. Basketball training system
US11813510B1 (en) 2016-11-08 2023-11-14 Airborne Athletics, Inc. Basketball training system
US11890521B1 (en) 2016-11-08 2024-02-06 Airborne Athletics, Inc. Basketball training system
US11026592B2 (en) * 2017-09-29 2021-06-08 Fitbit, Inc. Finger blood pressure cuff
US11382522B2 (en) 2017-09-29 2022-07-12 Fitbit, Inc. Position detection of blood pressure device
US11553848B2 (en) 2017-09-29 2023-01-17 Fitbit, Inc. Devices and methods for controlling inflation rate in blood pressure measurements
US11357412B2 (en) * 2018-11-20 2022-06-14 42 Health Sensor Holdings Ltd. Wearable cardiovascular monitoring device
AU2019383580B2 (en) * 2018-11-20 2022-10-27 42 Health Sensor Holdings, Ltd. Wearable cardiovascular monitoring device
USD972675S1 (en) 2019-09-06 2022-12-13 Airborne Athletics, Inc. Basketball passing machine
US11135500B1 (en) 2019-09-11 2021-10-05 Airborne Athletics, Inc. Device for automatic sensing of made and missed sporting attempts

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