US20010021074A1 - Optical filter holder assembly - Google Patents

Optical filter holder assembly Download PDF

Info

Publication number
US20010021074A1
US20010021074A1 US09/118,141 US11814198A US2001021074A1 US 20010021074 A1 US20010021074 A1 US 20010021074A1 US 11814198 A US11814198 A US 11814198A US 2001021074 A1 US2001021074 A1 US 2001021074A1
Authority
US
United States
Prior art keywords
filter
optical filter
optical
wheel
friction member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
US09/118,141
Other versions
US6313960B2 (en
Inventor
Samuel A. Marquiss
Calvin D. Wong
Glenn R. Edwards
Michael T. Taylor
Phil A. Garnieri
Douglas N. Modlin
Amer El-Hage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Devices LLC
Original Assignee
LJL Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US09/118,141 priority Critical patent/US6313960B2/en
Application filed by LJL Biosystems Inc filed Critical LJL Biosystems Inc
Priority to US09/144,575 priority patent/US6159425A/en
Priority to US09/144,578 priority patent/US6499366B1/en
Priority to US09/160,533 priority patent/US6097025A/en
Assigned to LJL BIOSYSTEMS, INC. reassignment LJL BIOSYSTEMS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MARQUISS. SAMUEL A., TAYLOR, MICHAEL T., GRANIERI, PHILIP A., JR., MODLIN, DOUGLAS N., EDWARDS, GLENN R., WONG, CALVIN D., EL-HAGE, AMER
Priority to US09/629,599 priority patent/US6469311B1/en
Priority to US09/733,370 priority patent/US20010007640A1/en
Publication of US20010021074A1 publication Critical patent/US20010021074A1/en
Application granted granted Critical
Publication of US6313960B2 publication Critical patent/US6313960B2/en
Priority to US10/445,292 priority patent/US6992761B2/en
Assigned to MOLECULAR DEVICES CORPORATION reassignment MOLECULAR DEVICES CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LJL BIOSYSTEMS, INC.
Assigned to MDS ANALYTICAL TECHNOLOGIES (US) INC. reassignment MDS ANALYTICAL TECHNOLOGIES (US) INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: MOLECULAR DEVICES CORPORATION
Assigned to MOLECULAR DEVICES, INC. reassignment MOLECULAR DEVICES, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: MDS ANALYTICAL TECHNOLOGIES (US) INC
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061The surface being organic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00691Automatic using robots
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • B01J2219/00707Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0829Multi-well plates; Microtitration plates
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809Multifield plates or multicontainer arrays
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/113332Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/113332Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114165Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/115831Condition or time responsive
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation

Definitions

  • Optical systems typically include many components, which interact to generate, transmit, modify, and detect light.
  • Light may be generated by light sources, transmitted by optical relay structures, and detected by detectors.
  • Light may be modified by optical filters positioned in an optical path in one or both of the light source and detector ends of the instrument.
  • filter holders have been developed that allow one of a plurality of optical filters to be selected and placed in an optical path. Examples include filter wheels and filter slides.
  • these filter holders have a number of shortcomings. In particular, the number of optical filters required even for a single application often exceeds the filter-holding capacity of a given filter holder. Therefore, it sometimes is necessary to replace the optical filters within a given filter holder.
  • Filter cartridges with removable optical filters also may employ a threaded retention member that can be screwed into the filter cartridge until a point where it holds the optical filter. This approach may require extra tools and be time-consuming. This approach also may force the retaining ring into a plane that is slightly skewed relative to the filter, misaligning the optical filter.
  • the invention provides a tool device for loading an optical filter into a holder.
  • the device includes a funnel structure having a top end and a lower edge configured to rest on top of a filter holder.
  • the funnel structure includes an inner diameter that enlarges gradually in a direction from the lower edge toward the top end.
  • the device also may include a slug for applying pressure to a friction member when loading the optical filter.
  • the invention provides an optical filter holder system that includes a holder having a plurality of apertures, and two sets of filter cartridges configured to fit in the apertures.
  • the first set of filter cartridges includes an optical filter permanently fixed in the filter cartridge.
  • the second set of filter cartridges includes a mechanism that permits easy replacement of different optical filters in the same filter cartridge.
  • the filter holder may include a filter wheel, and the mechanism that permits easy replacement my include a filter barrel and friction member.
  • FIG. 1 is a partially exploded perspective view of an optical filter wheel assembly constructed in accordance with the invention.
  • FIG. 2 is a partially exploded perspective view of a portion of an optical filter wheel assembly like that shown in FIG. 1, showing a mechanism by which short filter cartridges may be removed.
  • FIG. 3 is a partially exploded perspective view of the portion of the optical filter wheel assembly shown in FIG. 2, showing a mechanism by which tall filter cartridges may be removed.
  • FIG. 4 is a perspective view showing a mechanism by which optical filters may be placed in a tall filter cartridge.
  • FIG. 5 is a perspective view showing a mechanism by which a friction member may be pressed into place using a funnel and slug.
  • FIG. 6 is a top view of a short filter cartridge constructed in accordance with the invention.
  • FIG. 7 is a cross-sectional view of the short filter cartridge, taken generally along the line 7 - 7 in FIG. 6.
  • FIG. 8 is a top view of a short filter cartridge constructed in accordance with the invention.
  • FIG. 9 is a cross-sectional view of the short filter cartridge, taken generally along the line 9 - 9 in FIG. 8.
  • FIG. 10 is a top view of a funnel structure constructed in accordance with the invention.
  • FIG. 11 is a cross-sectional view of the funnel structure, taken generally along the line 11 - 11 in FIG. 10.
  • FIG. 12 is a partial perspective view of an alternative filter holder assembly constructed in accordance with the invention.
  • FIG. 1 shows a partially exploded perspective view of an optical filter wheel assembly 20 constructed in accordance with the present invention.
  • Optical filter wheel assembly 20 includes a filter wheel 22 that is rotatable about a hub structure 24 , and a wheel case having a static base portion 26 and a removable lid portion 28 .
  • Hub structure 24 is built into removable lid portion 28 .
  • Filter wheel 22 holds filter cartridges 30 .
  • Filter wheel 22 is substantially circular and includes a plurality of apertures 32 disposed symmetrically about its outer perimeter 34 . Apertures 32 are used for mounting filter cartridges 30 and may hold the filter cartridges via friction, threads, or other means.
  • Filter wheel 22 may have a variety of shapes, and apertures 28 may be disposed in a variety of configurations, although a symmetric embodiment is preferred for balance and ease of rotation about hub structure 24 .
  • Removable lid portion 28 holds filter wheel 22 .
  • Removable lid portion 28 is substantially rectangular, with an enclosed top 36 and sides 38 a - d and an open bottom 40 for receiving filter wheel 22 .
  • Opposed flanges 42 extend downward from one pair of opposed sides 38 b,d of removable lid portion 28 to support hub structure 24 .
  • Filter wheel 22 is rotatably mounted through its center on hub structure 24 .
  • Static base portion 26 holds removable lid portion 28 and filter wheel 22 .
  • Static base portion 26 is substantially rectangular, with an enclosed bottom 44 and sides 46 a - d and an open top 48 for receiving filter wheel 22 .
  • Opposed slots 50 extend downward into one pair of opposed sides 46 b,d of static base portion 26 to receive opposed flanges 42 .
  • Opposed posts 52 extend upward from the other pair of opposed sides 46 a,c of static base portion 26 to be received by opposed holes 54 in opposed sides 38 a,c of removable lid portion 28 .
  • Flanges 42 and slots 50 , and posts 52 and holes 54 individually and collectively form a post-to-hole mating structure that aligns static base portion 26 and removable lid portion 28 when the two portions are mated together to form the wheel case.
  • Captive screws 56 situated in holes 54 and accessible from top 36 may be threaded into posts 52 to hold together removable lid portion 28 and static base portion 26 .
  • Static base portion 26 further may be fixed to an instrument platform to form a portion of a light source module, detector module, or other optical assembly, among other applications.
  • the assembled wheel case is substantially light-tight, except for light that is transmitted through two sets of opposed windows 58 included in static base portion 26 .
  • Windows 58 are used for transmitting light through the wheel case and through a selected optical filter contained in a filter cartridge 30 in filter wheel 22 .
  • Windows 58 are located on opposite sides of hub structure 24 , so that any given optical filter in filter wheel 22 can be rotated into alignment with either set of windows.
  • light sources, detectors, and other optical components can be aligned with either or both sets of filters.
  • the wheel case includes at least one set of windows, which may be located on the static portion, removable portion, or other portion of the wheel case.
  • Filter wheel 22 may be rotated by a drive motor 60 , which is attached to removable lid portion 28 in optical filter wheel assembly 20 .
  • Drive motor 60 or other driver mechanisms also may be operatively connected to optical filter wheel assembly 20 at other points and in other manners.
  • FIG. 1 also shows a mechanism by which optical filter wheel assembly 20 may be disassembled and reassembled.
  • Optical filter wheel assembly 20 is disassembled as follows. First, any associated instrument is powered down and unplugged. Second, any secondary housing enclosing optical filter wheel assembly 20 is removed. Third, drive motor 60 is unplugged at its inline connector 62 . Fourth, captive screws 56 are loosened. Finally, removable lid portion 28 and filter wheel 22 are pulled out of static base portion 26 .
  • Optical filter wheel assembly 20 may be reassembled as follows. First, filter cartridges 30 are checked to verify that they are properly seated in filter wheel 22 , and filter wheel 22 is checked to verify that it rotates smoothly about hub structure 24 when moved by hand. Second, removable lid portion 28 and filter wheel 22 are inserted into static base portion 26 , aligning flanges 42 with slots 50 , and posts 52 with holes 54 . Third, captive screws 56 are tightened. Fourth, drive motor 60 is plugged back in at inline connector 62 . Fifth, any secondary housing is replaced. Finally, any associated instrument is plugged back in and powered up, if desired.
  • FIG. 2 shows a partially exploded perspective view of a removable portion 80 of an optical filter wheel assembly, including a filter wheel 82 , removable lid portion 84 , and drive motor 86 .
  • Filter wheel 82 includes a set of “short” filter cartridges 88 and a set of “tall” filter cartridges 90 .
  • Filter wheel 82 may hold a variety of filter cartridges, so long as the filter cartridges are configured to fit in apertures 92 in the filter wheel.
  • opposed apertures in filter wheel 82 should contain matching filter cartridges or a suitable slug to balance the filter wheel and to prevent unfiltered radiation from reaching a detector.
  • FIG. 2 also shows a mechanism by which short filter cartridges 88 may be removed and replaced.
  • short filter cartridges 88 include an optical filter 94 permanently affixed by suitable means, such as glue, to a short filter barrel 96 having a low profile.
  • Optical filter 94 may include an intensity filter, a spectral filter, or a polarization filter, among others.
  • Short filter cartridges 88 are removed from filter wheel 82 as follows. First, with the filter wheel removed as described above, the desired short filter cartridge is located by sight or by location. (Filter cartridge locations within the filter wheel may be marked on the filter wheel or elsewhere for reference.) Second, the short filter cartridge is removed by turning it counter-clockwise, which unscrews it.
  • the short filter cartridge may be turned by hand or by a special tool, such as a spanner wrench 98 having prongs 100 that engage grooves 102 in the sides of the short filter cartridge 104 .
  • a special tool such as a spanner wrench 98 having prongs 100 that engage grooves 102 in the sides of the short filter cartridge 104 .
  • filter changes are noted on the filter wheel or elsewhere and in any associated instrument software.
  • Short filter cartridges 88 may be replaced in filter wheel 82 by reversing the process, turning the short filter cartridge clockwise.
  • FIG. 3 shows a partially exploded perspective view of a removable portion 120 of an optical filter wheel assembly, as shown in FIG. 2.
  • FIG. 3 also shows a mechanism by which tall filter cartridges 122 may be removed and replaced.
  • tall filter cartridges 122 include an optical filter 124 affixed by a removable friction member 126 to a tall filter barrel 128 .
  • Optical filter 124 may include an intensity filter, a spectral filter, or a polarization filter, among others.
  • Friction member 126 and tall filter barrel 128 may be substantially annular.
  • Tall filter cartridges 122 may be removed from and replaced in filter wheel 130 much like short filter cartridges 88 ; however, tall filter cartridges 122 generally are turned by hand rather than by a tool.
  • FIGS. 4 and 5 show a perspective view of a mechanism by which optical filters may be replaced in the tall filter cartridges.
  • the optical filter 150 is placed in the tall filter barrel 152 .
  • Optical filter 150 should be oriented properly if one side is different than the other. Additional optical filters 150 can be placed in tall filter barrel 152 , if desired.
  • a funnel structure 154 is placed on top of tall filter barrel 152 .
  • an annular friction member 156 is placed in funnel structure 154 , followed by a slug 158 .
  • Slug 158 and optical filter 150 have approximately equivalent peripheral dimensions, including radii.
  • slug 158 is pushed down through funnel structure 154 to compress friction member 156 , which should fit snugly against optical filter 150 . Finally, slug 158 and funnel structure 154 are removed. The completed tall filter cartridge then can be installed in a filter wheel, as described above.
  • Optical filter 150 also may be replaced by other techniques.
  • the tall filter cartridges incorporate a mechanism that permits easy replacement of different optical filters in the same cartridge, enhancing the flexibility of the tall cartridges.
  • Optical filter 150 may be removed from the tall filter cartridge as follows. First, a lint-free cloth is placed on a work surface. Second, the installed optical filter 150 (or slug 158 ) is pushed gently near its center with a gloved finger or thumb, which will cause the optical filter 150 and friction member 156 to drop out of tall filter barrel 152 . Removed optical filter 150 should be stored so that it will not become dirty or scratched.
  • FIGS. 6 and 7 show detailed views of a short filter cartridge 180 , which includes a short filter barrel 182 and optical filter 184 .
  • Short filter barrel 182 is substantially annular, with a threaded lower portion 186 that screws into an aperture in a filter wheel, and a graspable upper portion 188 having a knurled rim 190 that may be turned by hand.
  • Optical filter 184 is supported by upper portion 188 , and mounts adjacent a stop structure 192 and inner wall 194 on short filter barrel 182 , so that it is substantially centered relative to short filter barrel 182 .
  • Stop structure 192 includes an edge 196 oriented substantially perpendicular to a principal plane of optical filter 184 and to inner wall 194 .
  • FIGS. 8 and 9 show detailed views of a tall filter cartridge 210 , which includes a tall filter barrel 212 and optical filter 214 .
  • Tall filter cartridge 210 resembles short filter cartridge 180 in many respects.
  • Tall filter barrel 212 is substantially annular, with a threaded lower portion 216 that screws into an aperture in a filter wheel, and a graspable upper portion 218 having a knurled rim 220 that may be turned by hand.
  • Optical filter 214 is supported by upper portion 218 , and mounts adjacent a stop structure 222 and inner wall 224 .
  • Stop structure 222 includes an edge 226 oriented substantially perpendicular to a principal plane of optical filter 214 and to inner wall 224 .
  • Inner wall 224 may be substantially perpendicular to the optical filter, as here, or it may have a funnel portion that graduates in diameter in a direction toward the stop structure, among other configurations.
  • Lower portion 186 of short filter barrel 182 is substantially identical to lower portion 216 of tall filter barrel 212 .
  • upper portion 188 of short filter barrel 182 is shorter than upper portion 218 of tall filter barrel 212 , giving it a lower profile.
  • optical filter 182 of short filter barrel 180 is permanently affixed to upper portion 188
  • optical filter 212 of tall filter barrel 210 is removably sandwiched in upper portion 218 between stop structure 222 and a friction member 226 .
  • Friction member 226 holds optical filter 212 in place relative to inner wall 224 in tall filter cartridge 210 by static friction, without any thread, groove, or adhesive. For this reason, among others, optical filters of various numbers and sizes may be secured.
  • Friction member 226 may take a variety of forms, including a compressible ring having an uncompressed outer diameter greater than the inner diameter of inner wall 224 .
  • the compressible ring may exert a force on the inner wall that provides sufficient static friction to hold an optical filter snugly in place during routine use, while also permitting easy removal when replacing optical filters.
  • FIGS. 10 and 11 show detailed views of a funnel structure 240 , which is used for loading an optical filter into a tall filter cartridge or other holder as described above.
  • Funnel structure 240 is substantially annular and includes inner and outer walls 242 , 244 and a top end 246 and lower edge 248 .
  • Lower edge 248 includes a groove 250 adjacent inner wall 242 configured to rest on top of a filter cartridge or other holder.
  • the inner diameter of funnel structure 240 measured between inner walls 242 enlarges gradually in a direction from lower edge 248 to top end 246 .
  • FIG. 12 shows a partial perspective view of an alternative filter holder assembly 270 .
  • Filter holder assembly 270 includes an elongate filter cartridge 272 and a base 274 .
  • Elongate filter cartridge 272 includes a filter end 276 and a pivot end 278 .
  • Filter end 278 is configured to hold optical filters, and includes two filter slots 280 a,b in which optical filters 281 may be glued or otherwise attached.
  • the filter end may hold one or more optical filters, using slots, apertures, short or tall filter cartridges, or other mechanisms.
  • Filter slots may be left open to allow light to pass unfiltered, include filters to filter light, or include slugs or other opaque structures to block light.
  • Pivot end 278 is configured turnably to attach to a hub structure, and includes an aperture 282 for receiving a drive axle or other pivot structure. Generally, the pivot end may attach through any means to any suitable drive mechanism.
  • Elongate filter cartridge 278 is fan shaped, filter end 276 being wider than pivot end 278 , although other shapes also are possible.
  • Base 272 generally supports elongate filter cartridge 272 .
  • Base 272 includes a hub structure 284 and major and walls 286 , 287 that substantially surround elongate filter cartridge 272 on all but one side.
  • Elongate filter cartridge 272 is turnably attached at its pivot end 278 to hub structure 284 through a drive axle 288 , about which it may turn.
  • Base 272 also includes a window 289 in major wall 286 .
  • Elongate filter cartridge 272 may be used for moving an optical filter in and out of an optical path, much like a filter wheel or filter slide, by turning elongate filter cartridge 272 about hub structure 284 . Because elongate filter cartridge 272 may move one or a few filters in and out of an optical path by turning through a limited angle, it may be configured to require less space than a filter wheel of comparable radius.
  • a drive mechanism 290 may be controlled or base 274 may be configured to limit the angle through which elongate filter cartridge 272 may turn. For example, in filter holder assembly 270 , a position 292 on minor wall 287 forms a stop structure that physically limits movement if drive mechanism 289 attempts to turn elongate filter cartridge 272 past the wall.

Abstract

Devices for using optical filters in a filter holder that enable optical filters to be simply, conveniently, and flexibly interchanged.

Description

    CROSS-REFERENCES TO RELATED APPLICATIONS
  • This application is a continuation of the following patent applications, each of which is incorporated herein by reference: U.S. patent application Ser. No. 09/062,472, filed Apr. 17, 1998; and PCT Patent Application Ser. No. ______, filed Jul. 15, 1998, titled LIGHT DETECTION DEVICE, and naming William B. Burton, Kimberly L. Crawford, Sudhir S. Deshpande, Glenn R. Edwards, Amer El-Hage, Todd E. French, Vladimir Lemberg, Joseph S. Leytes, Samuel a. Marquiss, John W. Meadows, Irina Mineyev, Douglas N. Modlin, John C. Owicki, Jon F. Peterson, Derrick A. Richardson, Rick V. Stellnacher, and Michael T. Taylor as inventors. [0001]
  • This application is based upon and claims benefit under 35 U.S.C. § 119 of the following U.S. Provisional Patent Applications, each of which is incorporated herein by reference: Ser. No. 60/052,876, filed Jul. 16, 1997; Ser. No. 60/059,639, filed Sep. 20, 1997; Ser. No. 60/063,811, filed Oct. 31, 1997; Ser. No. 60/072,499, filed Jan. 26, 1998; Ser. No. 60/072,780, filed Jan. 27, 1998; Ser. No. 60/075,414, filed Feb. 20, 1998; Ser. No. 60/075,806, filed Feb. 24, 1998; Ser. No. 60/082,253, filed Apr. 17, 1998; Ser. No. 60/084,167, filed May 4, 1998; Ser. No. 60/085,335, filed May 13, 1998; Ser. No. 60/085,500, filed May 14, 1998; and Ser. No. 60,089,848, filed Jun. 19, 1998. [0002]
  • This application incorporates by reference the following U.S. Patent Applications: Ser. No. ______, filed Jul. 16, 1998, titled MOVEABLE CONTROL UNIT, and naming Lev J. Leytes, William G. Burton, Yong Paik, Glenn R. Edwards, Douglas N. Modlin, and Amer-El Hage; and Ser. No. ______, filed Jul. 16, 1998, titled FLOATING HEAD ASSEMBLY, and naming Samuel A. Marquiss, Glenn R. Edwards, and Douglas N. Modlin as inventors.[0003]
  • FIELD OF THE INVENTION
  • The invention relates to optical filters. More particularly, the invention relates to devices for using optical filters in a filter holder that enable optical filters to be simply, conveniently, and flexibly interchanged. [0004]
  • BACKGROUND OF THE INVENTION
  • Optical systems typically include many components, which interact to generate, transmit, modify, and detect light. Light may be generated by light sources, transmitted by optical relay structures, and detected by detectors. Light may be modified by optical filters positioned in an optical path in one or both of the light source and detector ends of the instrument. [0005]
  • Optical filters modify the intensity, spectrum, polarization, and other properties of light. “Intensity filters” modify the intensity of light, where intensity is the amount of light per unit area per unit time. Intensity filters may absorb light, dissipating the absorbed energy as heat, or they may reflect or scatter light. “Spectral filters” modify the spectrum of light, where spectrum is the wavelength composition of light. Spectral filters may selectively transmit light of preselected wavelengths and selectively absorb, reflect, or scatter light of other wavelengths. A spectral filter may convert light of many colors into light of one or only a few colors. “Polarization filters” modify the polarization of light, where polarization is the direction of the electric field associated with light. [0006]
  • Different applications or conditions may require different optical filters. For this reason, filter holders have been developed that allow one of a plurality of optical filters to be selected and placed in an optical path. Examples include filter wheels and filter slides. Unfortunately, these filter holders have a number of shortcomings. In particular, the number of optical filters required even for a single application often exceeds the filter-holding capacity of a given filter holder. Therefore, it sometimes is necessary to replace the optical filters within a given filter holder. [0007]
  • Replacing optical filters may be difficult and time-consuming. If individual optical filters are affixed permanently to the filter holder, the entire filter holder may need to be replaced. If individual optical filters are affixed to removable filter cartridges within the filter holder, the filter holder still must be opened, individual filter cartridges removed and replaced, and the filter holder closed again. In known filter holders, filter cartridges must be replaced with the filter holder attached to an associated instrument. Working space may be minimal, and filter cartridges and other components may be dropped into the instrument, where they may cause damage and be difficult to retrieve. [0008]
  • Replacing optical filters within filter cartridges also may be difficult and time-consuming. Many or most optical filters are permanently affixed to any associated filter cartridge, and may not be replaced at all. Other optical filters may be removably affixed to an associated filter cartridge, but replaceable only with a limited selection or number of filters. Filter cartridges with removable optical filters may employ a retaining ring that fits into a groove on the inside of the filter cartridge to hold the optical filter. The groove establishes a predetermined position for the retaining ring, and may limit the thickness or number of replacement filters. Optical filters that are thicker than the provided space will not fit, and optical filters that are thinner than the provided space may require spacers. Filter cartridges with removable optical filters also may employ a threaded retention member that can be screwed into the filter cartridge until a point where it holds the optical filter. This approach may require extra tools and be time-consuming. This approach also may force the retaining ring into a plane that is slightly skewed relative to the filter, misaligning the optical filter. [0009]
  • SUMMARY OF THE INVENTION
  • The present invention addresses these and other shortcomings by providing filter cartridges and filter holders that enable optical filters to be simply, conveniently, and flexibly interchanged. [0010]
  • In one embodiment, the invention provides a device for holding an optical filter that includes a filter barrel having an inner wall and a stop structure, a removable annular friction member inside the filter barrel, and at least one optical filter sandwiched between the stop structure and the friction member. In this embodiment, the friction member is held in place relative to the inner wall by static friction, without any thread, groove, or adhesive. The filter barrel and friction member may take a variety of forms and may hold optical filters of various sizes and numbers. The friction member may hold the optical filter snugly in place during routine use, while also permitting easy removal when replacing optical filters. [0011]
  • In another embodiment, the invention provides a tool device for loading an optical filter into a holder. The device includes a funnel structure having a top end and a lower edge configured to rest on top of a filter holder. The funnel structure includes an inner diameter that enlarges gradually in a direction from the lower edge toward the top end. The device also may include a slug for applying pressure to a friction member when loading the optical filter. [0012]
  • In yet another embodiment, the invention provides an optical filter holder system that includes a holder having a plurality of apertures, and two sets of filter cartridges configured to fit in the apertures. The first set of filter cartridges includes an optical filter permanently fixed in the filter cartridge. The second set of filter cartridges includes a mechanism that permits easy replacement of different optical filters in the same filter cartridge. The filter holder may include a filter wheel, and the mechanism that permits easy replacement my include a filter barrel and friction member. [0013]
  • In yet another embodiment, the invention provides an optical filter wheel module including an optical filter wheel that is rotatable around a hub structure, and a wheel case having a static portion and a removable portion and at least one set of windows for transmitting light through the wheel case and through a selected optical filter contained in the optical filter wheel. The hub structure is built into the removable portion of the wheel case. The wheel case may be light tight and include more that one set of windows. [0014]
  • In yet another embodiment, the invention provides a device for holding an optical filter comprising a base having a hub structure, and an elongate filter cartridge having a filter end and a pivot end, the filter end configured to hold at least one optical filter, the pivot end configured turnably to attach to the hub structure, so that an optical filter can be turned between two positions about the hub structure. [0015]
  • The invention will be understood more readily after consideration of the drawings and the detailed description of the invention that follow.[0016]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a partially exploded perspective view of an optical filter wheel assembly constructed in accordance with the invention. [0017]
  • FIG. 2 is a partially exploded perspective view of a portion of an optical filter wheel assembly like that shown in FIG. 1, showing a mechanism by which short filter cartridges may be removed. [0018]
  • FIG. 3 is a partially exploded perspective view of the portion of the optical filter wheel assembly shown in FIG. 2, showing a mechanism by which tall filter cartridges may be removed. [0019]
  • FIG. 4 is a perspective view showing a mechanism by which optical filters may be placed in a tall filter cartridge. [0020]
  • FIG. 5 is a perspective view showing a mechanism by which a friction member may be pressed into place using a funnel and slug. [0021]
  • FIG. 6 is a top view of a short filter cartridge constructed in accordance with the invention. [0022]
  • FIG. 7 is a cross-sectional view of the short filter cartridge, taken generally along the line [0023] 7-7 in FIG. 6.
  • FIG. 8 is a top view of a short filter cartridge constructed in accordance with the invention. [0024]
  • FIG. 9 is a cross-sectional view of the short filter cartridge, taken generally along the line [0025] 9-9 in FIG. 8.
  • FIG. 10 is a top view of a funnel structure constructed in accordance with the invention. [0026]
  • FIG. 11 is a cross-sectional view of the funnel structure, taken generally along the line [0027] 11-11 in FIG. 10.
  • FIG. 12 is a partial perspective view of an alternative filter holder assembly constructed in accordance with the invention.[0028]
  • DETAILED DESCRIPTION OF THE INVENTION
  • FIG. 1 shows a partially exploded perspective view of an optical [0029] filter wheel assembly 20 constructed in accordance with the present invention. Optical filter wheel assembly 20 includes a filter wheel 22 that is rotatable about a hub structure 24, and a wheel case having a static base portion 26 and a removable lid portion 28. Hub structure 24 is built into removable lid portion 28.
  • [0030] Filter wheel 22 holds filter cartridges 30. Filter wheel 22 is substantially circular and includes a plurality of apertures 32 disposed symmetrically about its outer perimeter 34. Apertures 32 are used for mounting filter cartridges 30 and may hold the filter cartridges via friction, threads, or other means. Filter wheel 22 may have a variety of shapes, and apertures 28 may be disposed in a variety of configurations, although a symmetric embodiment is preferred for balance and ease of rotation about hub structure 24.
  • Removable lid portion [0031] 28 holds filter wheel 22. Removable lid portion 28 is substantially rectangular, with an enclosed top 36 and sides 38 a-d and an open bottom 40 for receiving filter wheel 22. Opposed flanges 42 extend downward from one pair of opposed sides 38 b,d of removable lid portion 28 to support hub structure 24. Filter wheel 22 is rotatably mounted through its center on hub structure 24.
  • [0032] Static base portion 26 holds removable lid portion 28 and filter wheel 22. Static base portion 26 is substantially rectangular, with an enclosed bottom 44 and sides 46 a-d and an open top 48 for receiving filter wheel 22. Opposed slots 50 extend downward into one pair of opposed sides 46 b,d of static base portion 26 to receive opposed flanges 42. Opposed posts 52 extend upward from the other pair of opposed sides 46 a,c of static base portion 26 to be received by opposed holes 54 in opposed sides 38 a,c of removable lid portion 28. Flanges 42 and slots 50, and posts 52 and holes 54, individually and collectively form a post-to-hole mating structure that aligns static base portion 26 and removable lid portion 28 when the two portions are mated together to form the wheel case. Captive screws 56 situated in holes 54 and accessible from top 36 may be threaded into posts 52 to hold together removable lid portion 28 and static base portion 26. Static base portion 26 further may be fixed to an instrument platform to form a portion of a light source module, detector module, or other optical assembly, among other applications.
  • The assembled wheel case is substantially light-tight, except for light that is transmitted through two sets of [0033] opposed windows 58 included in static base portion 26. Windows 58 are used for transmitting light through the wheel case and through a selected optical filter contained in a filter cartridge 30 in filter wheel 22. Windows 58 are located on opposite sides of hub structure 24, so that any given optical filter in filter wheel 22 can be rotated into alignment with either set of windows. In turn, light sources, detectors, and other optical components can be aligned with either or both sets of filters. Generally, the wheel case includes at least one set of windows, which may be located on the static portion, removable portion, or other portion of the wheel case.
  • [0034] Filter wheel 22 may be rotated by a drive motor 60, which is attached to removable lid portion 28 in optical filter wheel assembly 20. Drive motor 60 or other driver mechanisms also may be operatively connected to optical filter wheel assembly 20 at other points and in other manners.
  • FIG. 1 also shows a mechanism by which optical [0035] filter wheel assembly 20 may be disassembled and reassembled. Optical filter wheel assembly 20 is disassembled as follows. First, any associated instrument is powered down and unplugged. Second, any secondary housing enclosing optical filter wheel assembly 20 is removed. Third, drive motor 60 is unplugged at its inline connector 62. Fourth, captive screws 56 are loosened. Finally, removable lid portion 28 and filter wheel 22 are pulled out of static base portion 26.
  • Optical [0036] filter wheel assembly 20 may be reassembled as follows. First, filter cartridges 30 are checked to verify that they are properly seated in filter wheel 22, and filter wheel 22 is checked to verify that it rotates smoothly about hub structure 24 when moved by hand. Second, removable lid portion 28 and filter wheel 22 are inserted into static base portion 26, aligning flanges 42 with slots 50, and posts 52 with holes 54. Third, captive screws 56 are tightened. Fourth, drive motor 60 is plugged back in at inline connector 62. Fifth, any secondary housing is replaced. Finally, any associated instrument is plugged back in and powered up, if desired.
  • FIG. 2 shows a partially exploded perspective view of a removable portion [0037] 80 of an optical filter wheel assembly, including a filter wheel 82, removable lid portion 84, and drive motor 86. Filter wheel 82 includes a set of “short” filter cartridges 88 and a set of “tall” filter cartridges 90. Filter wheel 82 may hold a variety of filter cartridges, so long as the filter cartridges are configured to fit in apertures 92 in the filter wheel. Generally, opposed apertures in filter wheel 82 should contain matching filter cartridges or a suitable slug to balance the filter wheel and to prevent unfiltered radiation from reaching a detector.
  • FIG. 2 also shows a mechanism by which [0038] short filter cartridges 88 may be removed and replaced. Generally, short filter cartridges 88 include an optical filter 94 permanently affixed by suitable means, such as glue, to a short filter barrel 96 having a low profile. Optical filter 94 may include an intensity filter, a spectral filter, or a polarization filter, among others. Short filter cartridges 88 are removed from filter wheel 82 as follows. First, with the filter wheel removed as described above, the desired short filter cartridge is located by sight or by location. (Filter cartridge locations within the filter wheel may be marked on the filter wheel or elsewhere for reference.) Second, the short filter cartridge is removed by turning it counter-clockwise, which unscrews it. The short filter cartridge may be turned by hand or by a special tool, such as a spanner wrench 98 having prongs 100 that engage grooves 102 in the sides of the short filter cartridge 104. Finally, filter changes are noted on the filter wheel or elsewhere and in any associated instrument software. Short filter cartridges 88 may be replaced in filter wheel 82 by reversing the process, turning the short filter cartridge clockwise.
  • FIG. 3 shows a partially exploded perspective view of a [0039] removable portion 120 of an optical filter wheel assembly, as shown in FIG. 2. FIG. 3 also shows a mechanism by which tall filter cartridges 122 may be removed and replaced. Generally, tall filter cartridges 122 include an optical filter 124 affixed by a removable friction member 126 to a tall filter barrel 128. Optical filter 124 may include an intensity filter, a spectral filter, or a polarization filter, among others. Friction member 126 and tall filter barrel 128 may be substantially annular. Tall filter cartridges 122 may be removed from and replaced in filter wheel 130 much like short filter cartridges 88; however, tall filter cartridges 122 generally are turned by hand rather than by a tool.
  • FIGS. 4 and 5 show a perspective view of a mechanism by which optical filters may be replaced in the tall filter cartridges. First, as shown in FIG. 4, the [0040] optical filter 150 is placed in the tall filter barrel 152. Optical filter 150 should be oriented properly if one side is different than the other. Additional optical filters 150 can be placed in tall filter barrel 152, if desired. Second, as shown in FIG. 5, a funnel structure 154 is placed on top of tall filter barrel 152. Third, an annular friction member 156 is placed in funnel structure 154, followed by a slug 158. Slug 158 and optical filter 150 have approximately equivalent peripheral dimensions, including radii. Fourth, slug 158 is pushed down through funnel structure 154 to compress friction member 156, which should fit snugly against optical filter 150. Finally, slug 158 and funnel structure 154 are removed. The completed tall filter cartridge then can be installed in a filter wheel, as described above.
  • [0041] Optical filter 150 also may be replaced by other techniques. Generally, the tall filter cartridges incorporate a mechanism that permits easy replacement of different optical filters in the same cartridge, enhancing the flexibility of the tall cartridges.
  • [0042] Optical filter 150 may be removed from the tall filter cartridge as follows. First, a lint-free cloth is placed on a work surface. Second, the installed optical filter 150 (or slug 158) is pushed gently near its center with a gloved finger or thumb, which will cause the optical filter 150 and friction member 156 to drop out of tall filter barrel 152. Removed optical filter 150 should be stored so that it will not become dirty or scratched.
  • FIGS. 6 and 7 show detailed views of a [0043] short filter cartridge 180, which includes a short filter barrel 182 and optical filter 184. Short filter barrel 182 is substantially annular, with a threaded lower portion 186 that screws into an aperture in a filter wheel, and a graspable upper portion 188 having a knurled rim 190 that may be turned by hand. Optical filter 184 is supported by upper portion 188, and mounts adjacent a stop structure 192 and inner wall 194 on short filter barrel 182, so that it is substantially centered relative to short filter barrel 182. Stop structure 192 includes an edge 196 oriented substantially perpendicular to a principal plane of optical filter 184 and to inner wall 194.
  • FIGS. 8 and 9 show detailed views of a [0044] tall filter cartridge 210, which includes a tall filter barrel 212 and optical filter 214. Tall filter cartridge 210 resembles short filter cartridge 180 in many respects. Tall filter barrel 212 is substantially annular, with a threaded lower portion 216 that screws into an aperture in a filter wheel, and a graspable upper portion 218 having a knurled rim 220 that may be turned by hand. Optical filter 214 is supported by upper portion 218, and mounts adjacent a stop structure 222 and inner wall 224. Stop structure 222 includes an edge 226 oriented substantially perpendicular to a principal plane of optical filter 214 and to inner wall 224. Inner wall 224 may be substantially perpendicular to the optical filter, as here, or it may have a funnel portion that graduates in diameter in a direction toward the stop structure, among other configurations. Lower portion 186 of short filter barrel 182 is substantially identical to lower portion 216 of tall filter barrel 212. However, upper portion 188 of short filter barrel 182 is shorter than upper portion 218 of tall filter barrel 212, giving it a lower profile. In addition, optical filter 182 of short filter barrel 180 is permanently affixed to upper portion 188, whereas optical filter 212 of tall filter barrel 210 is removably sandwiched in upper portion 218 between stop structure 222 and a friction member 226. Friction member 226 holds optical filter 212 in place relative to inner wall 224 in tall filter cartridge 210 by static friction, without any thread, groove, or adhesive. For this reason, among others, optical filters of various numbers and sizes may be secured.
  • [0045] Friction member 226 may take a variety of forms, including a compressible ring having an uncompressed outer diameter greater than the inner diameter of inner wall 224. The compressible ring may exert a force on the inner wall that provides sufficient static friction to hold an optical filter snugly in place during routine use, while also permitting easy removal when replacing optical filters.
  • FIGS. 10 and 11 show detailed views of a [0046] funnel structure 240, which is used for loading an optical filter into a tall filter cartridge or other holder as described above. Funnel structure 240 is substantially annular and includes inner and outer walls 242, 244 and a top end 246 and lower edge 248. Lower edge 248 includes a groove 250 adjacent inner wall 242 configured to rest on top of a filter cartridge or other holder. The inner diameter of funnel structure 240 measured between inner walls 242 enlarges gradually in a direction from lower edge 248 to top end 246.
  • FIG. 12 shows a partial perspective view of an alternative [0047] filter holder assembly 270. Filter holder assembly 270 includes an elongate filter cartridge 272 and a base 274. Elongate filter cartridge 272 includes a filter end 276 and a pivot end 278. Filter end 278 is configured to hold optical filters, and includes two filter slots 280 a,b in which optical filters 281 may be glued or otherwise attached. Generally, the filter end may hold one or more optical filters, using slots, apertures, short or tall filter cartridges, or other mechanisms. Filter slots may be left open to allow light to pass unfiltered, include filters to filter light, or include slugs or other opaque structures to block light. Pivot end 278 is configured turnably to attach to a hub structure, and includes an aperture 282 for receiving a drive axle or other pivot structure. Generally, the pivot end may attach through any means to any suitable drive mechanism. Elongate filter cartridge 278 is fan shaped, filter end 276 being wider than pivot end 278, although other shapes also are possible.
  • [0048] Base 272 generally supports elongate filter cartridge 272. Base 272 includes a hub structure 284 and major and walls 286, 287 that substantially surround elongate filter cartridge 272 on all but one side. Elongate filter cartridge 272 is turnably attached at its pivot end 278 to hub structure 284 through a drive axle 288, about which it may turn. Base 272 also includes a window 289 in major wall 286.
  • [0049] Elongate filter cartridge 272 may be used for moving an optical filter in and out of an optical path, much like a filter wheel or filter slide, by turning elongate filter cartridge 272 about hub structure 284. Because elongate filter cartridge 272 may move one or a few filters in and out of an optical path by turning through a limited angle, it may be configured to require less space than a filter wheel of comparable radius. A drive mechanism 290 may be controlled or base 274 may be configured to limit the angle through which elongate filter cartridge 272 may turn. For example, in filter holder assembly 270, a position 292 on minor wall 287 forms a stop structure that physically limits movement if drive mechanism 289 attempts to turn elongate filter cartridge 272 past the wall.
  • Accordingly, while the invention has been disclosed in preferred forms, the specific embodiments thereof as disclosed and illustrated herein are not to be considered in a limiting sense, because numerous variations are possible and no single feature, function, or property of the preferred embodiments are essential. The invention is to be defined only by the scope of the issued claims. [0050]

Claims (26)

We claim:
1. A device for holding an optical filter, the device comprising:
a filter barrel having an inner wall and a stop structure;
a removable annular friction member inside the filter barrel; and
at least one optical filter sandwiched between the stop structure and the friction member, wherein the friction member is held in place relative to the inner wall by static friction, without any thread, groove, or adhesive.
2. The device of
claim 1
, wherein the inner wall is substantially parallel to the optical filter.
3. The device of
claim 1
, wherein the inner wall has a funnel portion that graduates in diameter in a direction progressing away from the stop structure.
4. The device of
claim 1
, wherein the friction member is a compressible ring having an uncompressed outer diameter greater than the inner diameter of the inner wall.
5. The device of
claim 4
, wherein the compressible ring exerts a force on the inner wall that provides sufficient static friction to hold the optical filter snugly in place during routine use, while also permitting easy removal when replacing optical filters.
6. The device of
claim 1
, wherein the optical filter is an intensity filter, a spectral filter, or a polarization filter.
7. A tool device for loading an optical filter into a holder, the device comprising a funnel structure having a top end and a lower edge configured to rest on top of a filter holder, wherein the funnel structure has an inner diameter that enlarges gradually in a direction from the lower edge toward the top end.
8. The device of
claim 7
, further comprising a slug for applying pressure to a friction member when loading the optical filter, wherein the slug and the optical filter have approximately equivalent peripheral dimensions.
9. An optical filter holder system, the system comprising:
a holder having a plurality of apertures; and
first and second sets of filter cartridges configured to fit in the apertures, each of the first set of filter cartridges having an optical filter permanently fixed in the filter cartridge, each of the second set of filter cartridges having a mechanism that permits easy replacement of different optical filters in the same filter cartridge.
10. The system of
claim 9
, wherein the holder includes a filter wheel.
11. The system of
claim 9
, wherein each of filter cartridges has a lower portion that is threaded to screw into any one of the apertures.
12. The system of
claim 9
, wherein the mechanism comprises:
a filter barrel having an inner wall and a stop structure; and
a removable annular friction member inside the filter barrel, wherein an optical filter can be sandwiched securely inside the filter barrel between the stop structure and the friction member, wherein the friction member is held in place relative to the inner wall by static friction, without any thread, groove, or adhesive.
13. An optical filter wheel module, the module comprising:
an optical filter wheel that is rotatable around a hub structure; and,
a wheel case having a static portion and a removable portion, and at least one set of windows for transmitting light through the wheel case and through a selected optical filter contained in the optical filter wheel, wherein the hub structure is built into the removable portion of the wheel case.
14. The module of
claim 13
, wherein the wheel case is substantially light-tight, except for light that is transmitted through the windows.
15. The module of
claim 13
, wherein the windows are in the static portion of the wheel case.
16. The module of
claim 13
, wherein the windows are in the removable portion of the wheel case.
17. The module of
claim 13
, wherein the wheel case has a second set of windows, the sets of windows being located on opposite sides of the hub structure, so that any given optical filter in the optical filter wheel can be rotated into alignment with either set of windows.
18. The module of
claim 13
, further comprising a post-to-hole mating structure that aligns the portions of the wheel case.
19. The module of
claim 13
, wherein the static portion of the wheel case is fixed to an instrument platform.
20. The module of
claim 13
, further comprising a driver mechanism configured to rotate the optical filter wheel.
21. A device for holding an optical filter, the device comprising:
a base having a hub structure; and
an elongate filter cartridge having a filter end and a pivot end, the filter end configured to hold at least one optical filter, the pivot end configured turnably to attach to the hub structure, so that an optical filter can be turned between two positions about the hub structure.
22. The device of
claim 21
, wherein the filter end is configured to hold two optical filters side by side, so that either optical filter can be aligned with a selected position about the hub structure.
23. The device of
claim 21
, wherein the base substantially surrounds the elongate filter cartridge on at least one side, the base including at least one window for transmitting light through the base and through a selected optical filter aligned with the window.
24. The device of
claim 21
, wherein the base is configured to limit the angle through which the elongate filter cartridge may turn.
25. The device of
claim 21
, wherein the elongate filter cartridge generally is fan shaped, the filter end being wider than the pivot end.
26. The device of
claim 21
, further including a driver mechanism configured to turn the elongate filter cartridge.
US09/118,141 1997-07-16 1998-07-16 Optical filter holder assembly Expired - Fee Related US6313960B2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US09/118,141 US6313960B2 (en) 1997-07-16 1998-07-16 Optical filter holder assembly
US09/144,575 US6159425A (en) 1997-07-16 1998-08-31 Sample transporter
US09/144,578 US6499366B1 (en) 1997-07-16 1998-08-31 Sample feeder
US09/160,533 US6097025A (en) 1997-10-31 1998-09-24 Light detection device having an optical-path switching mechanism
US09/629,599 US6469311B1 (en) 1997-07-16 2000-07-31 Detection device for light transmitted from a sensed volume
US09/733,370 US20010007640A1 (en) 1997-07-16 2000-12-08 Sample transporter
US10/445,292 US6992761B2 (en) 1997-09-20 2003-05-22 Broad range light detection system

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US5287697P 1997-07-16 1997-07-16
US5963997P 1997-09-20 1997-09-20
US6381197P 1997-10-31 1997-10-31
US7249998P 1998-01-26 1998-01-26
US7278098P 1998-01-27 1998-01-27
US7541498P 1998-02-20 1998-02-20
US7580698P 1998-02-24 1998-02-24
US8225398P 1998-04-17 1998-04-17
US09/062,472 US6071748A (en) 1997-07-16 1998-04-17 Light detection device
US8416798P 1998-05-04 1998-05-04
US8533598P 1998-05-13 1998-05-13
US8550098P 1998-05-14 1998-05-14
US8984898P 1998-06-19 1998-06-19
US09/118,141 US6313960B2 (en) 1997-07-16 1998-07-16 Optical filter holder assembly

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
US09/062,472 Continuation US6071748A (en) 1997-07-16 1998-04-17 Light detection device
PCT/US1998/014575 Continuation WO1999004228A2 (en) 1997-07-16 1998-07-15 Light detection device
US09/118,310 Continuation US6033100A (en) 1997-07-16 1998-07-16 Floating head assembly

Related Child Applications (7)

Application Number Title Priority Date Filing Date
PCT/US1998/014575 Continuation WO1999004228A2 (en) 1997-07-16 1998-07-15 Light detection device
US09/118,310 Continuation US6033100A (en) 1997-07-16 1998-07-16 Floating head assembly
US09/144,578 Continuation US6499366B1 (en) 1997-07-16 1998-08-31 Sample feeder
US09/144,575 Continuation US6159425A (en) 1997-07-16 1998-08-31 Sample transporter
US09/146,081 Continuation US6187267B1 (en) 1997-07-16 1998-09-02 Chemiluminescence detection device
US09/160,533 Continuation US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism
US09/733,370 Continuation US20010007640A1 (en) 1997-07-16 2000-12-08 Sample transporter

Publications (2)

Publication Number Publication Date
US20010021074A1 true US20010021074A1 (en) 2001-09-13
US6313960B2 US6313960B2 (en) 2001-11-06

Family

ID=27584468

Family Applications (8)

Application Number Title Priority Date Filing Date
US09/062,472 Expired - Lifetime US6071748A (en) 1997-07-16 1998-04-17 Light detection device
US09/118,141 Expired - Fee Related US6313960B2 (en) 1997-07-16 1998-07-16 Optical filter holder assembly
US09/118,341 Expired - Lifetime US6025985A (en) 1997-07-16 1998-07-16 Moveable control unit for high-throughput analyzer
US09/118,310 Expired - Lifetime US6033100A (en) 1997-07-16 1998-07-16 Floating head assembly
US09/144,578 Expired - Fee Related US6499366B1 (en) 1997-07-16 1998-08-31 Sample feeder
US09/144,575 Expired - Lifetime US6159425A (en) 1997-07-16 1998-08-31 Sample transporter
US09/146,081 Expired - Lifetime US6187267B1 (en) 1997-07-16 1998-09-02 Chemiluminescence detection device
US09/733,370 Abandoned US20010007640A1 (en) 1997-07-16 2000-12-08 Sample transporter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US09/062,472 Expired - Lifetime US6071748A (en) 1997-07-16 1998-04-17 Light detection device

Family Applications After (6)

Application Number Title Priority Date Filing Date
US09/118,341 Expired - Lifetime US6025985A (en) 1997-07-16 1998-07-16 Moveable control unit for high-throughput analyzer
US09/118,310 Expired - Lifetime US6033100A (en) 1997-07-16 1998-07-16 Floating head assembly
US09/144,578 Expired - Fee Related US6499366B1 (en) 1997-07-16 1998-08-31 Sample feeder
US09/144,575 Expired - Lifetime US6159425A (en) 1997-07-16 1998-08-31 Sample transporter
US09/146,081 Expired - Lifetime US6187267B1 (en) 1997-07-16 1998-09-02 Chemiluminescence detection device
US09/733,370 Abandoned US20010007640A1 (en) 1997-07-16 2000-12-08 Sample transporter

Country Status (5)

Country Link
US (8) US6071748A (en)
EP (1) EP1012579A2 (en)
JP (1) JP2002509235A (en)
IL (1) IL134069A0 (en)
WO (1) WO1999004228A2 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120182438A1 (en) * 2011-01-17 2012-07-19 Kathrin Berkner Multi-imaging System with Interleaved Images
CN104198394A (en) * 2014-09-09 2014-12-10 中国科学院电工研究所 Photoacoustic spectrometry detection device with detachable optical filter plate structure
US9219866B2 (en) 2013-01-07 2015-12-22 Ricoh Co., Ltd. Dynamic adjustment of multimode lightfield imaging system using exposure condition and filter position
US20160355322A1 (en) * 2015-06-05 2016-12-08 Hap Innovations, Llc System and method for reliably dispensing pre-packaged pharmaceuticals
US20170003498A1 (en) * 2015-07-01 2017-01-05 Materion Corporation Unbalanced hub design
WO2017019747A1 (en) * 2015-07-30 2017-02-02 Molecular Devices, Llc Optical element alignment and retention for optical instruments
US20180086547A1 (en) * 2016-09-23 2018-03-29 Hap Innovations, Llc System and method for reliably dispensing pre-packaged pharmaceuticals
US10176663B2 (en) 2016-07-06 2019-01-08 Spencer Health Solutions, Llc System and method for loading a dispensing cassette useful in a system for dispensing pre-packaged pharmaceuticals
US10966908B2 (en) * 2018-09-21 2021-04-06 AGEvoluzione S.r.l.s. Dispenser of substance doses with dish for collection thereof

Families Citing this family (268)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030054543A1 (en) * 1997-06-16 2003-03-20 Lafferty William Michael Device for moving a selected station of a holding plate to a predetermined location for interaction with a probe
US6469311B1 (en) * 1997-07-16 2002-10-22 Molecular Devices Corporation Detection device for light transmitted from a sensed volume
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6258326B1 (en) 1997-09-20 2001-07-10 Ljl Biosystems, Inc. Sample holders with reference fiducials
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6576476B1 (en) * 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
WO2000050877A1 (en) 1999-02-23 2000-08-31 Ljl Biosystems, Inc. Frequency-domain light detection device
US6326605B1 (en) 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
US6486947B2 (en) * 1998-07-22 2002-11-26 Ljl Biosystems, Inc. Devices and methods for sample analysis
US6297018B1 (en) * 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
US6992761B2 (en) * 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
US6982431B2 (en) * 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
JP3731700B2 (en) * 1997-12-25 2006-01-05 興和株式会社 Fluorescent particle imaging device
CA2316912C (en) * 1998-01-12 2009-09-15 Massachusetts Institute Of Technology Method and apparatus for performing microassays
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6493600B1 (en) * 1998-02-05 2002-12-10 Canon Kabushiki Kaisha Semiconductor manufacturing apparatus
EP2045334A1 (en) * 1998-06-24 2009-04-08 Illumina, Inc. Decoding of array sensors with microspheres
AU5667599A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
AU5223899A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
US6236456B1 (en) * 1998-08-18 2001-05-22 Molecular Devices Corporation Optical system for a scanning fluorometer
US6201690B1 (en) * 1998-09-01 2001-03-13 Emc Corporation Rack console assembly
US6528801B1 (en) * 1998-11-04 2003-03-04 The Research Foundation Of State University Of New York Method and apparatus for detecting radiation
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6130745A (en) * 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
AU3748800A (en) * 1999-03-16 2000-10-04 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
CA2367912A1 (en) 1999-03-19 2000-09-28 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
JP2002543434A (en) 1999-04-29 2002-12-17 デイド マイクロスキャン インコーポレーテッド A system that combines a rapid antimicrobial susceptibility assay with microbial identification
US6287774B1 (en) * 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
US6472141B2 (en) * 1999-05-21 2002-10-29 Caliper Technologies Corp. Kinase assays using polycations
ATE497164T1 (en) 1999-06-09 2011-02-15 Molecular Devices Inc TEST METHODS FOR MEASURING PHOSPHORYLATION
JP3076568B1 (en) * 1999-07-15 2000-08-14 株式会社鈴木 Drilling method for film for electronic parts
CA2380307A1 (en) * 1999-07-21 2001-02-01 Tropix, Inc. Luminescence detection workstation
US7138254B2 (en) 1999-08-02 2006-11-21 Ge Healthcare (Sv) Corp. Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins
US6979425B1 (en) * 1999-10-04 2005-12-27 Robodesign International, Inc. High capacity microarray dispensing
US6814933B2 (en) 2000-09-19 2004-11-09 Aurora Biosciences Corporation Multiwell scanner and scanning method
US6448089B1 (en) * 1999-10-12 2002-09-10 Aurora Biosciences Corporation Multiwell scanner and scanning method
US6586257B1 (en) 1999-10-12 2003-07-01 Vertex Pharmaceuticals Incorporated Multiwell scanner and scanning method
JP2003512615A (en) * 1999-10-15 2003-04-02 グラクソ グループ リミテッド Method and apparatus for monitoring solid phase chemical reactions
ATE334397T1 (en) * 1999-12-21 2006-08-15 Tecan Trading Ag CLAMPING DEVICE FOR RECEIVING AND PRECISELY POSITIONING AN OBJECT, PREFERABLY A MICROTITER PLATE, AND METHOD FOR OPERATING IT
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US20010055765A1 (en) * 2000-02-18 2001-12-27 O'keefe Matthew Apparatus and methods for parallel processing of micro-volume liquid reactions
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US6775567B2 (en) * 2000-02-25 2004-08-10 Xenogen Corporation Imaging apparatus
US6566143B2 (en) 2000-02-25 2003-05-20 Cambridge Research & Instrumentation, Inc. Multiple label fluorescence polarization assay system and method
US20030117705A1 (en) * 2000-02-25 2003-06-26 Cambridge Research & Instrumentation Inc. Fluorescence polarization assay system and method
US6329661B1 (en) * 2000-02-29 2001-12-11 The University Of Chicago Biochip scanner device
US6447723B1 (en) * 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US6927851B2 (en) * 2000-03-31 2005-08-09 Neogen Corporation Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
FR2807543B1 (en) * 2000-04-06 2004-11-05 Imstar S A IMAGING APPARATUS ASSOCIATED WITH AN IMAGE DATABASE
US6369894B1 (en) * 2000-05-01 2002-04-09 Nalco Chemical Company Modular fluorometer
DE10026647A1 (en) * 2000-05-29 2001-12-06 Merck Patent Gmbh Positioning device
US6746648B1 (en) * 2000-06-15 2004-06-08 Beckman Coulter, Inc. Method and system for transporting and storing multiple reagent packs and reagent packs used therein
US6795189B2 (en) * 2000-06-15 2004-09-21 Packard Instrument Company Universal microplate analyzer
CA2410090A1 (en) * 2000-06-15 2001-12-20 Irm, Llc Automated precision object holder
JP4622052B2 (en) * 2000-06-29 2011-02-02 株式会社ニコン Light measurement method and microplate
JP4494606B2 (en) * 2000-08-11 2010-06-30 浜松ホトニクス株式会社 Liquid-containing substance analysis apparatus and liquid-containing substance analysis method
DE10042999A1 (en) * 2000-09-01 2002-03-14 Merck Patent Gmbh Positioning device, used for glass microtiter plates for analyzing chemical and biological samples, comprises a holding frame, a support surface partially surrounded by lateral protrusions
ATE458992T1 (en) * 2000-09-04 2010-03-15 Bayer Technology Services Gmbh SYSTEM AND METHOD FOR MULTIANALYTE DETERMINATION
EP1325459A4 (en) * 2000-10-13 2010-09-01 Irm Llc High throughput processing system and method of using
AU2002245047A1 (en) 2000-10-30 2002-07-24 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
AUPR121200A0 (en) * 2000-11-03 2000-11-30 Campbell Corporation Pty Ltd A replicator system and components thereof
US6821787B2 (en) 2000-11-17 2004-11-23 Thermogenic Imaging, Inc. Apparatus and methods for infrared calorimetric measurements
US20020132360A1 (en) 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
US20040110301A1 (en) * 2000-11-17 2004-06-10 Neilson Andy C Apparatus and methods for measuring reaction byproducts
WO2002048693A1 (en) * 2000-12-14 2002-06-20 Olympus Optical Co., Ltd. Fluorometric analyzer and fluorometric analysis
US6525816B2 (en) * 2000-12-28 2003-02-25 3M Innovative Properties Company Method for measuring the absolute light throughput of reflective-mode displays in an optical system
US6949377B2 (en) * 2001-03-05 2005-09-27 Ho Winston Z Chemiluminescence-based microfluidic biochip
US6570158B2 (en) * 2001-06-02 2003-05-27 Hya Feygin Method and apparatus for infrared-spectrum imaging
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US20030039383A1 (en) * 2001-06-26 2003-02-27 Bio-Rad Laboratories, Inc. Flat field correction of two-dimensional biochemical assay images
US7348587B2 (en) * 2001-06-28 2008-03-25 Fujifilm Corporation Method for producing biochemical analysis data and apparatus used therefor
US20030003594A1 (en) * 2001-06-28 2003-01-02 Fuji Photo Film Co. Ltd. Method for producing biochemical analysis data and scanner used therefor
US7115232B2 (en) * 2001-07-13 2006-10-03 Hudson Gordon S Fluorescence validation microplate and method of use
EP1281966A3 (en) * 2001-07-30 2003-06-18 Fuji Photo Film Co., Ltd. Method and apparatus for conducting a receptor-ligand reaction
US6740890B1 (en) * 2001-08-15 2004-05-25 Chen-Yu Tai Time-resolved light decay measurements without using a gated detector
US7223985B2 (en) * 2001-08-28 2007-05-29 Rudolf Rigler Single-channel multicolored correlation analysis
JP2003098086A (en) 2001-09-21 2003-04-03 Olympus Optical Co Ltd Light intensity measuring device
US20030085362A1 (en) * 2001-11-02 2003-05-08 Valery Bogdanov Method and system for detection of an analytical chip plate
US20030129755A1 (en) * 2001-11-07 2003-07-10 Genvault Corporation System and method of storing and retrieving storage elements
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
US20030087425A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier
US7584240B2 (en) 2001-11-07 2009-09-01 Genvault Corporation Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients
US6922246B2 (en) * 2002-02-22 2005-07-26 Xenogen Corporation Bottom fluorescence illumination assembly for an imaging apparatus
US7474399B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Dual illumination system for an imaging apparatus and method
US7474398B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Illumination system for an imaging apparatus with low profile output device
US6798520B2 (en) * 2002-03-22 2004-09-28 Diversa Corporation Method for intensifying the optical detection of samples that are held in solution in the through-hole wells of a holding tray
US7142400B1 (en) * 2002-03-27 2006-11-28 Cypress Semiconductor Corp. Method and apparatus for recovery from power supply transient stress conditions
US20030183337A1 (en) * 2002-03-28 2003-10-02 James Fordemwalt Apparatus and method for use of optical diagnostic system with a plasma processing system
AU2002253623A1 (en) * 2002-04-26 2003-11-10 Allied Telesis K.K. Optical wireless communication device and method for adjusting the position of optical wireless communication device
DE10221564A1 (en) * 2002-05-15 2003-11-27 Evotec Ag Photoluminescence analyzer for chemical and biological sample screening uses a high intensity homogeneous line image as illumination source, and has multiple sensor scanning of the image
JP2003021593A (en) * 2002-05-20 2003-01-24 Aloka Co Ltd Specimen examination device
EP1513948B1 (en) * 2002-05-29 2009-04-15 Autogenomics, Inc. Integrated micro array system and methods therefor
CH693689A5 (en) * 2002-05-31 2003-12-15 Tecan Trading Ag Apparatus to transfer fluids from solid phase extraction plates, for solid phase extraction/elution of organic/inorganic matter, has a controlled transfer unit with the sample carrier for transfer to micro-plates
CA2391641A1 (en) * 2002-06-28 2003-12-28 Robert Longin Robotic platform of cellular cultures in miniaturized reactor batteries, equipped with a system for real-time measurement of cell turbidity and all other optical properties
AU2003256285A1 (en) * 2002-06-28 2004-01-19 Igen International, Inc. Improved assay systems and components
US20040126275A1 (en) * 2002-07-31 2004-07-01 Klaus Doering Method and device for measuring the lifetime of the fluorescence of fluorophores in samples
DE20214868U1 (en) * 2002-07-31 2003-03-13 Tecan Trading Ag Maennedorf Device for measuring the lifetime of fluorescence from fluorophores in samples
GB0219457D0 (en) * 2002-08-21 2002-09-25 Amersham Biosciences Uk Ltd Fluorescence reference plate
US6878949B2 (en) * 2002-08-22 2005-04-12 Genextix Limited Gel imaging and excision
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US20040057870A1 (en) * 2002-09-20 2004-03-25 Christer Isaksson Instrumentation for optical measurement of samples
GB0222397D0 (en) * 2002-09-27 2002-11-06 Arrayjet Ltd Method and apparatus for substrate handling and printing
US20040087010A1 (en) * 2002-11-04 2004-05-06 Chung-Hua Tsai Micro ELISA reader
US7718442B2 (en) * 2002-11-22 2010-05-18 Genvault Corporation Sealed sample storage element system and method
US6934030B2 (en) * 2002-12-18 2005-08-23 The Research Foundation Of State University Of New York Method and apparatus for detecting radiation
AU2003302264A1 (en) 2002-12-20 2004-09-09 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
FR2849196B1 (en) * 2002-12-23 2006-09-15 Imstar Image Et Modelisation S BIOPUCES-LIKE CHIP READER, AND ASSOCIATED METHODS
US7122153B2 (en) * 2003-01-08 2006-10-17 Ho Winston Z Self-contained microfluidic biochip and apparatus
CA2513985C (en) * 2003-01-21 2012-05-29 Illumina Inc. Chemical reaction monitor
JP4381122B2 (en) * 2003-02-14 2009-12-09 晶宇生物科技實業股▲分▼有限公司 Micro-array biochip reflective image access and analysis device with sidewall and method thereof
AU2003900902A0 (en) * 2003-02-27 2003-03-13 Varian Australia Pty Ltd Spectrophotometer
US6765734B1 (en) * 2003-03-14 2004-07-20 Hinds Instruments, Inc. Adjustable sample holder for optical equipment
US20100075858A1 (en) * 2003-04-29 2010-03-25 Genvault Corporation Biological bar code
US7396650B2 (en) * 2003-06-27 2008-07-08 Commissariat A L'energie Atomique Method for dosing a biological or chemical sample
US20060226374A1 (en) * 2003-08-06 2006-10-12 Gnothis Holding S.A. Method and device for identifying luminescent molecules according to the fluorescence correlation spectroscopy method
JP2007504445A (en) * 2003-08-26 2007-03-01 ブルーシフト・バイオテクノロジーズ・インコーポレーテッド Time-dependent fluorescence measurement
US20060013984A1 (en) * 2003-09-19 2006-01-19 Donald Sandell Film preparation for seal applicator
US20050232818A1 (en) * 2003-09-19 2005-10-20 Donald Sandell Single sheet seal applicator and cartridge
US20050280811A1 (en) * 2003-09-19 2005-12-22 Donald Sandell Grooved high density plate
US20060011305A1 (en) * 2003-09-19 2006-01-19 Donald Sandell Automated seal applicator
US20060029948A1 (en) * 2003-09-19 2006-02-09 Gary Lim Sealing cover and dye compatibility selection
WO2005029041A2 (en) * 2003-09-19 2005-03-31 Applera Corporation High density sequence detection methods and apparatus
US20050226780A1 (en) * 2003-09-19 2005-10-13 Donald Sandell Manual seal applicator
DE10356154B4 (en) * 2003-12-02 2006-04-20 Leica Microsystems (Schweiz) Ag Changing device for optical elements
JP3991029B2 (en) * 2003-12-19 2007-10-17 株式会社日立ハイテクノロジーズ Nucleic acid analyzer
WO2005081801A2 (en) * 2004-02-09 2005-09-09 Blueshift Biotechnologies, Inc. Methods and apparatus for scanning small sample volumes
ATE543117T1 (en) * 2004-02-16 2012-02-15 Olympus Corp IMMERSION LENS, RETENTION MECHANISM FOR AN IMMERSION MEDIUM AND PRODUCTION METHOD THEREOF
JP2007529015A (en) 2004-03-12 2007-10-18 バイオトローブ, インコーポレイテッド Nanoliter array loading
US6987563B2 (en) * 2004-04-14 2006-01-17 Hudson Gordon S Luminescense validation microplate
DE102004021664A1 (en) * 2004-05-03 2005-12-08 H+P Labortechnik Ag Microtitration plate shaker for e.g. pharmaceutical, chemical or biological research, has locators driven between working- and release positions
US20050250173A1 (en) * 2004-05-10 2005-11-10 Davis Charles Q Detection device, components of a detection device, and methods associated therewith
US7019526B2 (en) * 2004-05-24 2006-03-28 Varian, Inc. Sample catcher for NMR apparatus and method utilizing thereof
ATE441669T1 (en) 2004-05-24 2009-09-15 Genvault Corp STABLE STORAGE OF PROTEIN AND STABLE STORAGE OF NUCLEIC ACID IN RECOVERABLE FORM
ATE510205T1 (en) * 2004-06-17 2011-06-15 Bayer Healthcare Llc COAXIAL READING HEAD FOR MEASURING DIFFUSE REFLECTION
EP1760455A4 (en) * 2004-06-21 2016-12-21 Olympus Corp Measuring apparatus
WO2006004769A2 (en) * 2004-06-28 2006-01-12 Aspectrics, Inc. Encoder spectrograph for analyzing radiation using spatial modulation of radiation dispersed by wavelength
JP2008505321A (en) 2004-07-02 2008-02-21 ブルーシフト・バイオテクノロジーズ・インコーポレーテッド Search for phosphor microenvironment
US20060018802A1 (en) * 2004-07-09 2006-01-26 Greenway Roger B Jr Method and apparatus for reconfiguring a labware storage system
US20060013730A1 (en) * 2004-07-16 2006-01-19 Pollock Paul W Method and apparatus for handling labware within a storage device
US20060105453A1 (en) * 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
US6970241B1 (en) 2004-08-24 2005-11-29 Desa Richard J Device for enabling slow and direct measurement of fluorescence polarization
JP2008512666A (en) 2004-09-10 2008-04-24 ワラック オサケ ユキチュア Instruments and methods compatible with optical measurements of amplified luminescent proximity homogeneity assay (Amplified Luminescent Proximity Homogenous Assay)
EP1794575A4 (en) * 2004-09-28 2011-06-22 Glaxo Group Ltd Luminescense sensor apparatus and method
WO2006083917A2 (en) * 2005-02-01 2006-08-10 Purdue Research Foundation Laser scanning interferometric surface metrology
US7910356B2 (en) 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US20070023643A1 (en) * 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US20060193752A1 (en) * 2005-02-25 2006-08-31 Levine Leanna M Microvolume flowcell apparatus
US7957507B2 (en) 2005-02-28 2011-06-07 Cadman Patrick F Method and apparatus for modulating a radiation beam
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US8232535B2 (en) 2005-05-10 2012-07-31 Tomotherapy Incorporated System and method of treating a patient with radiation therapy
GB0509611D0 (en) * 2005-05-11 2005-06-15 Amersham Biosciences Ab Method and device for imaging a sample
JPWO2007010803A1 (en) * 2005-07-15 2009-01-29 オリンパス株式会社 Light measuring device
WO2007014107A2 (en) * 2005-07-22 2007-02-01 Tomotherapy Incorporated System and method of monitoring the operation of a medical device
DE602006021803D1 (en) 2005-07-22 2011-06-16 Tomotherapy Inc A system for delivering radiotherapy to a moving target area
WO2007014106A2 (en) * 2005-07-22 2007-02-01 Tomotherapy Incorporated System and method of delivering radiation therapy to a moving region of interest
US8442287B2 (en) 2005-07-22 2013-05-14 Tomotherapy Incorporated Method and system for evaluating quality assurance criteria in delivery of a treatment plan
EP1906827A4 (en) 2005-07-22 2009-10-21 Tomotherapy Inc System and method of evaluating dose delivered by a radiation therapy system
CA2616292A1 (en) 2005-07-22 2007-02-01 Tomotherapy Incorporated Method and system for evaluating quality assurance criteria in delivery of a treament plan
EP3175886B1 (en) 2005-07-23 2018-06-27 TomoTherapy, Inc. Radiation therapy imaging and delivery utilizing coordinated motion of gantry and couch
US7805081B2 (en) * 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
JP5055282B2 (en) 2005-09-14 2012-10-24 イルミナ インコーポレイテッド Continuous polymer synthesizer
US7527437B2 (en) * 2005-09-30 2009-05-05 Rockwell Automation Technologies, Inc. Sensor mounting structure with light pipe
US7412900B2 (en) * 2005-09-30 2008-08-19 Rockwell Automation Technologies, Inc. Sensor mounting structure with adjustable swivel ball and panel mounting mechanism
US7546780B2 (en) * 2005-09-30 2009-06-16 Rockwell Automation Technologies, Inc. Sensor mounting structure allowing for adjustment of sensor position
US7415891B2 (en) * 2005-09-30 2008-08-26 Rockwell Automation Technologies, Inc. Sensor mounting structure with snapping feature
DE102005048807B3 (en) * 2005-10-10 2006-11-16 Johann Wolfgang Goethe-Universität Apparatus for quantitative or qualitative determination of infrared active contents of liquid based or non-liquid fluids
US20070098596A1 (en) * 2005-10-14 2007-05-03 University Of South Florida Handheld microarray reader
US7727473B2 (en) * 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
WO2008057111A2 (en) 2005-12-21 2008-05-15 Meso Scale Technologies, Llc Assay apparatuses, methods and reagents
FI20051329A0 (en) 2005-12-27 2005-12-27 Wallac Oy Apparatus and method for optical measurement of samples
JP4735288B2 (en) 2006-01-27 2011-07-27 ブラザー工業株式会社 Droplet ejector
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) * 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) * 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7678330B2 (en) * 2006-03-01 2010-03-16 Aleksandr Ostrovsky System, method and apparatus for use in blood testing through luminescence
US20070207483A1 (en) * 2006-03-02 2007-09-06 Bio-Rad Laboratories, Inc. BUFFERS FOR DETECTION OF mRNA SEPARATED IN A MICROFLUIDIC DEVICE
US20070248494A1 (en) * 2006-04-24 2007-10-25 Mokelke Michael F Multi-Mode Modular Method and Apparatus for Micro-titer Plate Analysis
US20070259366A1 (en) * 2006-05-03 2007-11-08 Greg Lawrence Direct printing of patterned hydrophobic wells
US20080006202A1 (en) * 2006-06-26 2008-01-10 Applera Corporation Compressible transparent sealing for open microplates
CA2662521C (en) * 2006-09-01 2016-08-09 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US20080080059A1 (en) * 2006-09-28 2008-04-03 Pacific Biosciences Of California, Inc. Modular optical components and systems incorporating same
WO2008042565A2 (en) * 2006-09-29 2008-04-10 Glaxo Group Limited Method and system for rapid phase luminescense spectroscopy analysis
US20080230605A1 (en) * 2006-11-30 2008-09-25 Brian Weichel Process and apparatus for maintaining data integrity
US7522282B2 (en) * 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
US20080144899A1 (en) * 2006-11-30 2008-06-19 Manoj Varma Process for extracting periodic features from images by template matching
US7746465B2 (en) * 2007-01-18 2010-06-29 Hinds Instruments, Inc. Sample holder for an optical element
WO2008089495A2 (en) * 2007-01-19 2008-07-24 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
US7700928B2 (en) * 2007-01-25 2010-04-20 Etaluma, Inc. Apparatus and method for interleaving detection of fluorescence and luminescence
US9557217B2 (en) 2007-02-13 2017-01-31 Bti Holdings, Inc. Universal multidetection system for microplates
US7782454B2 (en) * 2007-02-13 2010-08-24 Bti Holdings, Inc. Universal multidetection system for microplates
CA2681722A1 (en) * 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
FR2916047B1 (en) * 2007-05-11 2010-06-04 Force A METHOD AND SYSTEM FOR CHARACTERIZING BIOLOGICAL TISSUE
US7566173B2 (en) * 2007-07-09 2009-07-28 Alcon, Inc. Multi-spot ophthalmic laser probe
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
US20090130772A1 (en) * 2007-11-15 2009-05-21 Kauko Lehtinen Apparatus and method for collecting data on light-emitting reactions
US9211549B2 (en) 2007-12-11 2015-12-15 Tripath Imaging, Inc. Sequential centrifuge
CN101878434B (en) 2008-04-10 2014-05-07 普拉德研究及开发股份有限公司 Method for characterizing a geological formation traversed by a borehole
US8725477B2 (en) * 2008-04-10 2014-05-13 Schlumberger Technology Corporation Method to generate numerical pseudocores using borehole images, digital rock samples, and multi-point statistics
CN108362681B (en) 2008-04-11 2021-08-17 梅索斯卡莱科技公司 Analytical device, method and reagent
JP2012501681A (en) 2008-09-12 2012-01-26 ジェンボールト コーポレイション Matrix and media for storage and stabilization of biomolecules
CA2737505C (en) 2008-09-16 2017-08-29 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
HUE062440T2 (en) * 2008-10-09 2023-11-28 Lgc Genomics Llc Scanner photometer head and associated method
US9921101B2 (en) * 2008-10-09 2018-03-20 Douglas Scientific, LLC Scanner photometer and methods
US8759795B2 (en) * 2011-04-07 2014-06-24 Douglas Scientific, Llc. Scanner photometer and methods
KR101018121B1 (en) 2008-12-10 2011-02-25 삼성엘이디 주식회사 Method for Inspecting Concave and Convex Patterns of LED
GB2467788B (en) * 2009-02-16 2014-05-07 Qioptiq Ltd An optical adaptor
US8311788B2 (en) * 2009-07-01 2012-11-13 Schlumberger Technology Corporation Method to quantify discrete pore shapes, volumes, and surface areas using confocal profilometry
US20110004447A1 (en) * 2009-07-01 2011-01-06 Schlumberger Technology Corporation Method to build 3D digital models of porous media using transmitted laser scanning confocal mircoscopy and multi-point statistics
JP5813914B2 (en) * 2009-04-27 2015-11-17 株式会社東芝 Automatic analyzer
EP3229029B1 (en) 2009-05-15 2021-03-03 Gen-Probe Incorporated Method and apparatus for effecting transfer of reaction receptacles in an instrument for multi-step analytical procedures
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US8696992B2 (en) 2009-08-06 2014-04-15 Universal Bio Research Co., Ltd. Optical fiber measurement device and measurement method using same
EP2503970B1 (en) * 2009-11-24 2015-09-16 Alcon Research, Ltd. Single-fiber multi-spot laser probe for ophthalmic endoillumination
WO2011081887A1 (en) * 2009-12-15 2011-07-07 Los Alamos National Security, Llc High throughput fiber optical assembly for fluorescence spectrometry
US8951244B2 (en) * 2009-12-15 2015-02-10 Alcon Research, Ltd. Multi-spot laser probe
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
EP2537010A4 (en) 2010-02-19 2013-12-25 Pacific Biosciences California Optics collection and detection system and method
CN103221529B (en) 2010-02-23 2015-05-27 卢米尼克斯公司 Apparatus and methods for integrated sample preparation, reaction and detection
JP5056871B2 (en) * 2010-03-02 2012-10-24 横河電機株式会社 Confocal microscope system
CN102279462B (en) * 2010-06-09 2013-02-06 北京赛尔蒂扶科技发展有限公司 Automatic glass slide conveying and loading device
DE102010061742B4 (en) * 2010-11-22 2013-07-04 Gabo Qualimeter Testanlagen Gmbh Test device with a sample holder and sample holder for holding a sample
IT1403792B1 (en) * 2010-12-30 2013-10-31 St Microelectronics Srl ANALYZER FOR BIOCHEMICAL ANALYSIS AND METHOD FOR DETERMINING CONCENTRATIONS OF FLUORESCENT SUBSTANCES IN A SOLUTION
CN107338189B (en) 2011-05-04 2021-02-02 卢米耐克斯公司 Apparatus and method for integrated sample preparation, reaction and detection
CN103842794B (en) * 2011-07-22 2017-09-22 罗氏血液诊断股份有限公司 fluid sample preparation system and method
CN103930008B (en) * 2011-11-15 2017-07-14 雀巢产品技术援助有限公司 The optical readable code supporter of the readable optical signalling of enhancing and the capsule with this code supporter for preparing beverage are provided
US9475025B2 (en) * 2011-12-29 2016-10-25 General Electric Company Microfluidic handling system
CH706326A2 (en) * 2012-03-14 2013-09-30 Tecan Trading Ag Procedures and microplate readers for study of biological cells or cell cultures.
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
AU2013202804A1 (en) 2012-06-14 2014-01-16 Gen-Probe Incorporated Use of a fluorescent material to detect failure or deteriorated performance of a fluorometer
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
WO2014031327A2 (en) * 2012-08-20 2014-02-27 Siemens Healthcare Diagnostics Inc. Clam-shell luminometer
EP4123294A1 (en) 2012-12-18 2023-01-25 Pacific Biosciences Of California, Inc. An optical analytical device
US10245181B2 (en) 2012-12-21 2019-04-02 Alcon Research, Ltd. Grin fiber multi-spot laser probe
EP4345460A2 (en) * 2013-01-04 2024-04-03 Meso Scale Technologies, LLC. Assay apparatuses, methods and reagents
EP2959283B1 (en) 2013-02-22 2022-08-17 Pacific Biosciences of California, Inc. Integrated illumination of optical analytical devices
CN105027227B (en) 2013-02-26 2017-09-08 安科锐公司 Electromagnetically actuated multi-diaphragm collimator
US20150177236A1 (en) * 2013-03-15 2015-06-25 Gold Standard Diagnostics Combined chemiluminescence and elisa automated sample reader
CN103257446B (en) * 2013-05-31 2016-01-13 中国科学院长春光学精密机械与物理研究所 For the path switching mechanisms of soft X-ray-extreme ultraviolet waveband optical system
WO2015047821A1 (en) * 2013-09-30 2015-04-02 Gt Crystal Systems, Llc Adjustable pyrometer mount with removable viewport mechanism
CH708820A1 (en) * 2013-11-07 2015-05-15 Tecan Trading Ag Inkubationskassette.
US9063705B2 (en) 2013-11-11 2015-06-23 Lenovo Enterprise Solutions (Singapore) Pte. Ltd. Latch mechanism for securing an electronic module
WO2015181951A1 (en) * 2014-05-30 2015-12-03 株式会社ニコン Focusing device, microscope device, focusing method, and control program
JP2016017766A (en) * 2014-07-04 2016-02-01 株式会社島津製作所 Light detection circuit and luminous power measurement device
CN107003241B (en) 2014-08-27 2022-01-11 加利福尼亚太平洋生物科学股份有限公司 Integrated analytical device array
ES2673371T3 (en) * 2014-12-08 2018-06-21 Milestone S.R.L. Container and method for collecting, transporting and storing biological tissue samples
US10487356B2 (en) 2015-03-16 2019-11-26 Pacific Biosciences Of California, Inc. Integrated devices and systems for free-space optical coupling
AU2016276980B2 (en) 2015-06-12 2021-09-23 Pacific Biosciences Of California, Inc. Integrated target waveguide devices and systems for optical coupling
EP3321659A4 (en) * 2015-07-09 2019-01-16 Olympus Corporation Chromoscopy device and chromoscopy method
CN105527450B (en) * 2015-12-31 2017-11-03 中国科学院苏州生物医学工程技术研究所 A kind of micropore substrate transfer device for fully-automated synthesis instrument
FR3055559B1 (en) * 2016-09-07 2018-08-31 Dreampath Diagnostics DEVICE FOR DETECTING, STORING AND ORDERING SAMPLE BLADES.
JP7356351B2 (en) 2016-12-12 2023-10-04 エクセラ・バイオサイエンシーズ・インコーポレイテッド Methods and systems for screening using microcapillary arrays
WO2018204890A1 (en) 2017-05-05 2018-11-08 Zymergen Inc. Microbial engineering methods and systems for optimizing microbe fitness
EP3801212A1 (en) * 2018-06-06 2021-04-14 Progenity, Inc. Ingestible device with on-board fluorometer and related systems and methods
JP7219119B2 (en) * 2019-03-01 2023-02-07 株式会社日立ハイテク automatic analyzer
JP7151636B2 (en) * 2019-06-14 2022-10-12 東芝三菱電機産業システム株式会社 data collection device
EP3855174A1 (en) * 2020-01-23 2021-07-28 SCHOTT Schweiz AG Detection and characterization of defects in pharmaceutical cylindrical containers
CN114578075B (en) * 2022-05-07 2022-10-28 深圳市帝迈生物技术有限公司 Method and system for starting sample detection system and computer readable storage device
DE102022206219A1 (en) 2022-06-22 2023-12-28 Robert Bosch Gesellschaft mit beschränkter Haftung Optical system with filter carrier

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2719214A (en) * 1951-01-26 1955-09-27 Potter Edward Airport marker with flexible support
US3013467A (en) * 1957-11-07 1961-12-19 Minsky Marvin Microscopy apparatus
US3176577A (en) * 1962-05-02 1965-04-06 Gomer S Frank Visual color comparator having a rotatable color keyed standard
US3423581A (en) * 1966-10-26 1969-01-21 Gen Motors Corp Remote illumination apparatus
US3516736A (en) * 1967-01-16 1970-06-23 Weaver Co W R Focussing objective for telescope sights
US3849654A (en) * 1973-10-19 1974-11-19 H Malvin Fluorescence cuvette
US3885162A (en) 1973-10-31 1975-05-20 Contraves Goerz Corp Optical measuring apparatus
US4074939A (en) 1973-12-19 1978-02-21 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Apparatus for investigating fast chemical reactions by optical detection
DE2408646A1 (en) * 1974-02-22 1975-08-28 Max Planck Gesellschaft REACTION KINETIC MEASURING DEVICE
US3932023A (en) * 1974-11-18 1976-01-13 E. I. Du Pont De Nemours & Company Optical coupler for transmitting light linearly between a single point and plural points
US4341957A (en) * 1975-11-26 1982-07-27 Analytical Radiation Corporation Fluorescent antibody composition for immunofluorometric assay
US4011451A (en) * 1975-07-03 1977-03-08 Waters Associates, Incorporated Novel photometric system
US4144452A (en) * 1976-07-08 1979-03-13 International Diagnostic Technology, Inc. Fluorometric system, method and test article
FR2359433A1 (en) * 1976-07-23 1978-02-17 Thomson Csf ADJUSTABLE RADIATION DISTRIBUTOR GUIDED BY OPTICAL FIBER BEAMS
US4067653A (en) * 1976-08-27 1978-01-10 Nasa Differential optoacoustic absorption detector
US4100416A (en) * 1977-03-02 1978-07-11 Block Engineering, Inc. Serum fluorescence suppression
US4203670A (en) * 1977-04-21 1980-05-20 Bromberg Nathan S System and method of fluorescence polarimetry
US4240751A (en) 1978-11-09 1980-12-23 Akzona Incorporated Method and apparatus for specific binding substances
GB2047402B (en) 1979-03-06 1983-03-09 De La Rue Thomas & Co Ltd Watermark detection
US4451149A (en) * 1980-07-28 1984-05-29 Noeller Hans Guenter Polarization fluoroimmunoassay apparatus
IT8267058A0 (en) * 1981-01-22 1982-01-21 Cibie Projecteurs ADDITIONAL HEADLIGHT FOR VEHICLES
US4397560A (en) 1981-04-23 1983-08-09 Bio-Tek Instruments, Inc. Photometer with microtray well position indicator
JPS5848836A (en) * 1981-09-18 1983-03-22 Toa Medical Electronics Co Ltd Optical type automatic analyzing and measuring device
DE3246274C2 (en) * 1981-12-14 1985-05-30 Olympus Optical Co., Ltd., Tokio/Tokyo Analyzer working with immunological agglutination reaction
JPS58102161A (en) * 1981-12-15 1983-06-17 Olympus Optical Co Ltd Automatic blood inspective device
US4501970A (en) * 1982-10-12 1985-02-26 Dynatech Laboratories Incorporated Fluorometer
JPS5970946A (en) * 1982-10-15 1984-04-21 Toshiba Corp Apparatus for measuring absorbance
US4626684A (en) * 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US4704255A (en) * 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
US4567847A (en) * 1983-08-23 1986-02-04 Board Of Regents, The University Of Texas System Apparatus and method for cryopreparing biological tissue for ultrastructural analysis
US4724217A (en) * 1983-10-31 1988-02-09 The United States Of America As Represented By The United States Department Of Energy Ultratrace analysis of transuranic actinides by laser-induced fluorescence
DE3568087D1 (en) * 1984-02-22 1989-03-09 Siemens Ag Optoelectronic housing module
US5112134A (en) 1984-03-01 1992-05-12 Molecular Devices Corporation Single source multi-site photometric measurement system
US4968148A (en) * 1984-03-01 1990-11-06 Molecular Devices Corporation Single source multi-site photometric measurement system
US5500188A (en) 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
US4849330A (en) 1984-04-27 1989-07-18 Molecular Devices Corporation Photoresponsive redox detection and discrimination
US4883579A (en) 1984-04-27 1989-11-28 Molecular Devices Corporation Photoresponsive redox detection and discrimination
US4704353A (en) 1984-04-27 1987-11-03 Molecular Devices Corporation Photoresponsive redox detection and discrimination
JPS6125030A (en) * 1984-07-13 1986-02-03 Hitachi Ltd Fluorescence-polarization measuring apparatus
US4738825A (en) * 1985-02-27 1988-04-19 Fisher Scientific Company Cuvette handling
US4772453A (en) * 1985-03-01 1988-09-20 Lisenbee Wayne F Luminiscence measurement arrangement
US5096807A (en) * 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US5047215A (en) * 1985-06-18 1991-09-10 Polyfiltronics, Inc. Multiwell test plate
US4948442A (en) * 1985-06-18 1990-08-14 Polyfiltronics, Inc. Method of making a multiwell test plate
US4877965A (en) * 1985-07-01 1989-10-31 Diatron Corporation Fluorometer
EP0213825A3 (en) 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US4737464A (en) 1985-09-26 1988-04-12 Molecular Devices Corporation Solid-state optical assay imaging apparatus
US4873633A (en) * 1985-10-18 1989-10-10 Cetus Corporation User controlled off-center light absorbance reading adjuster in a liquid handling and reaction system
US4730921A (en) * 1985-10-31 1988-03-15 Genetic Systems, Inc. Photodensitometer for minimizing the refractive effects of a fluid sample
JPS62129741A (en) 1985-12-02 1987-06-12 Hitachi Ltd Photoacoustic analysis method and apparatus
US4646214A (en) * 1986-01-09 1987-02-24 Mendleski Ronald J Miniature coaxial lighting assembly
US4753501A (en) * 1986-01-15 1988-06-28 The United States Of America As Represented By The Secretary Of The Air Force Fiber optic rotary switching device
US5009488A (en) * 1986-02-11 1991-04-23 University Of Massachusetts Medical Center Filter accessory for an imaging microspectrofluorimeter
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CH669851A5 (en) 1986-03-06 1989-04-14 Tecan Ag
US5206568A (en) * 1986-03-26 1993-04-27 Beckman Instruments, Inc. Coordinated control of stepper motors
GB8607975D0 (en) * 1986-04-01 1986-05-08 Fisons Plc Devices
US4802768A (en) 1986-04-11 1989-02-07 Sclavo, Inc. Two light source reference system for a fluorometer
GB2190195A (en) * 1986-05-09 1987-11-11 Cambridge Life Sciences Microtitre plate reader
US5270788A (en) * 1986-05-27 1993-12-14 Boris Cercek Apparatus for measuring polarization of bathochromically shifted fluorescence
US4911794A (en) 1986-06-20 1990-03-27 Molecular Devices Corporation Measuring with zero volume cell
US4915812A (en) 1986-06-20 1990-04-10 Molecular Devices Corporation Zero volume cell
US4758786A (en) 1986-08-06 1988-07-19 Molecular Devices Corporation Method of analyzing semiconductor systems
US4784275A (en) * 1986-09-15 1988-11-15 Vanzetti Systems Inc. Verification systems for small objects
US4801804A (en) 1986-09-30 1989-01-31 Trebor Industries, Inc. Method and apparatus for near infrared reflectance measurement of non-homogeneous materials
EP0266881A3 (en) 1986-09-30 1990-04-04 Astromed Limited Method and apparatus for multiple optical assaying
US5084246A (en) * 1986-10-28 1992-01-28 Costar Corporation Multi-well test plate
US4885087A (en) * 1986-11-26 1989-12-05 Kopf Henry B Apparatus for mass transfer involving biological/pharmaceutical media
US4923819A (en) * 1987-03-27 1990-05-08 Chimerix Corporation Time-resolved fluorescence immunoassay
US4855930A (en) * 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
US4741619A (en) * 1987-05-05 1988-05-03 Molecular Devices Corporation Hydrophilic microplates for vertical beam photometry
US4826660A (en) * 1987-05-07 1989-05-02 Becton, Dickinson And Company Detector assembly for analyzer instrument
US4963815A (en) 1987-07-10 1990-10-16 Molecular Devices Corporation Photoresponsive electrode for determination of redox potential
US4936682A (en) * 1987-08-11 1990-06-26 Associates Of Cape Cod, Inc. Instrument for independently and kinetically measuring light transpassion through a plurality of samples
DE3879209D1 (en) * 1987-08-27 1993-04-15 Polyfiltronics Ltd FILTER UNITS FOR THE PREPARATION OF BIOLOGICAL SAMPLES.
CH673534A5 (en) 1987-10-19 1990-03-15 Tecan Ag
US4979821A (en) * 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
GB2215838B (en) 1988-02-12 1992-10-21 Nat Res Dev Fluorimeters
US4892409A (en) * 1988-07-14 1990-01-09 Smith Harry F Photometric apparatus for multiwell plates having a positionable lens assembly
US5278048A (en) 1988-10-21 1994-01-11 Molecular Devices Corporation Methods for detecting the effect of cell affecting agents on living cells
WO1990004645A1 (en) 1988-10-21 1990-05-03 Molecular Devices Corporation Methods and apparatus for detecting the effect of cell affecting agents on living cells
US5798083A (en) 1988-11-03 1998-08-25 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration and chemiluminescence detection
US5746974A (en) 1988-11-03 1998-05-05 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence and chemiluminescence detection
GB2228081B (en) 1988-12-06 1993-07-07 Loughborough Consult Ltd A fluorimeter, and a method of carrying out a fluorescent assay of a plurality of analytes
US5020995A (en) 1989-01-18 1991-06-04 Guy Levy Surgical treatment method and instrument
US5252293A (en) 1989-01-17 1993-10-12 Vladimir Drbal Analytical slide with porous filter membrane
US5160702A (en) 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
WO1990009637A1 (en) * 1989-02-13 1990-08-23 Research Corporation Technologies, Inc. Method and means for parallel frequency acquisition in frequency domain fluorometry
US5039219A (en) * 1989-05-26 1991-08-13 Photon Technology Luminescence system and method for determining the nature of substances by measuring fluorescence and phosphorescence properties
US5480804A (en) * 1989-06-28 1996-01-02 Kirin Beverage Corporation Method of and apparatus for detecting microorganisms
US5018866A (en) 1989-09-12 1991-05-28 Packard Instrument Company Method and apparatus for performing high sensitivity fluorescence measurements
US5082628A (en) * 1989-09-19 1992-01-21 Park Pharmaceuticals, Inc. Luminometer
US5198670A (en) 1989-09-29 1993-03-30 Packard Instrument Company Scintillation counting system for in-situ measurement of radioactive samples in a multiple-well plate
US5034613A (en) 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
GB9001701D0 (en) 1990-01-25 1990-03-28 Gersan Ets Optical inspection method and apparatus
IT1239223B (en) * 1990-02-20 1993-09-28 Pirelli Cavi Spa ADJUSTABLE OPTICAL CONNECTOR FOR CONNECTION OF OPTICAL FIBERS TO DISCRETE OPTICAL COMPONENTS AND SENSOR USING ONE OR MORE ADJUSTABLE CONNECTORS
US5058045A (en) * 1990-03-09 1991-10-15 Ma Hsi K Battery and expansion slot changeable computer
DE4013586C2 (en) * 1990-04-27 1994-08-18 Suzuki Motor Co Device for the detection of immunological agglutination
EP0527726A1 (en) * 1990-05-08 1993-02-24 Wallac Oy An apparatus for counting liquid scintillation samples
JPH0678978B2 (en) * 1990-05-25 1994-10-05 スズキ株式会社 Aggregation pattern detector
US5104804A (en) 1990-06-04 1992-04-14 Molecular Devices Corporation Cell assay device used in a microphysiometer
SE9002579D0 (en) * 1990-08-07 1990-08-07 Pharmacia Ab METHOD AND APPARATUS FOR CARRYING OUT BIOCHEMICAL REACTIONS
FI86340C (en) 1990-10-31 1992-08-10 Labsystems Oy Procedure for conducting light
EP0568596A1 (en) * 1991-01-24 1993-11-10 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
FR2672128B1 (en) 1991-01-28 1995-08-18 Cis Bio Int METHOD FOR MEASURING THE LUMINESCENCE EMITTED IN A LUMINESCENCE ASSAY.
US5192510A (en) * 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
EP0517930B1 (en) 1991-06-08 1995-05-24 Hewlett-Packard GmbH Method and apparatus for detecting the presence and/or concentration of biomolecules
EP0588972A4 (en) * 1991-06-13 1994-09-14 Abbott Lab Optical imaging for positioning and cell counting
US5208651A (en) * 1991-07-16 1993-05-04 The Regents Of The University Of California Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes
US5289407A (en) 1991-07-22 1994-02-22 Cornell Research Foundation, Inc. Method for three dimensional optical data storage and retrieval
JP3027241B2 (en) * 1991-07-30 2000-03-27 株式会社堀場製作所 Foreign matter inspection device
US5225164A (en) * 1991-09-30 1993-07-06 Astle Thomas W Microplate laboratory tray with rectilinear wells
US5345395A (en) * 1991-10-31 1994-09-06 Baxter Diagnostics Inc. Specimen processing and analyzing systems and methods using photometry
US5266272A (en) * 1991-10-31 1993-11-30 Baxter Diagnostics Inc. Specimen processing and analyzing systems with a station for holding specimen trays during processing
JPH06504136A (en) 1991-10-31 1994-05-12 マイクロスキャン、インコーポレイテッド Specimen processing and analysis system with associated liquid dispensing equipment
JPH05157684A (en) 1991-12-02 1993-06-25 Seikagaku Kogyo Co Ltd Absorptionmeter
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US5361626A (en) * 1992-01-29 1994-11-08 United States Surgical Corporation Method and apparatus for detecting leaks in sealed packages
US5635402A (en) 1992-03-05 1997-06-03 Alfano; Robert R. Technique for determining whether a cell is malignant as opposed to non-malignant using extrinsic fluorescence spectroscopy
DE69330772T2 (en) * 1992-03-09 2002-07-04 Accumed Internat Inc DIAGNOSTIC MICROBIOLOGICAL TEST DEVICE AND METHOD
US5323008A (en) * 1992-03-23 1994-06-21 Diatron Corporation Fluorometer detection system
JP2561367Y2 (en) * 1992-04-03 1998-01-28 東亞医用電子株式会社 Sample suction and discharge device
US5401465A (en) * 1992-05-05 1995-03-28 Chiron Corporation Luminometer with reduced sample crosstalk
US5319436A (en) * 1992-05-28 1994-06-07 Packard Instrument Company, Inc. Microplate farming wells with transparent bottom walls for assays using light measurements
US5470754A (en) 1992-06-01 1995-11-28 The Coca-Cola Company Method and system for sampling and determining the presence of compounds
US5620864A (en) 1992-06-29 1997-04-15 Health Research, Inc. Acceptor for fucosyl transferase
US5357095A (en) * 1992-07-16 1994-10-18 Schiapparelli Biosystems, Inc. Reagent bottle identification and reagent monitoring system for a chemical analyzer
US5290521A (en) 1992-09-04 1994-03-01 Destefano Jr Albert M Lab-top work station
US5736410A (en) 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5355215A (en) * 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
US5825617A (en) 1992-10-02 1998-10-20 Teletransactions, Inc. Workslate computer having modular device docking stations on horizontal and vertical side portions
WO1994011489A1 (en) * 1992-11-06 1994-05-26 Biolog, Inc. Testing device for liquid and liquid suspended samples
US5315015A (en) * 1992-11-10 1994-05-24 Hoffmann-La Roche Inc. Compounds having improved fluorescence in fluorescence polarization immunoassays and immunoassays utilizing same
JP2575270B2 (en) * 1992-11-10 1997-01-22 浜松ホトニクス株式会社 Method for determining base sequence of nucleic acid, method for detecting single molecule, apparatus therefor and method for preparing sample
US5445935A (en) 1992-11-23 1995-08-29 Royer; Catherine A. Quantitative detection of macromolecules with fluorescent oligonucleotides
JP2753930B2 (en) * 1992-11-27 1998-05-20 キヤノン株式会社 Immersion type projection exposure equipment
US5323010A (en) 1992-12-01 1994-06-21 I.S.S. (Usa) Inc. Time resolved optical array detectors and CCD cameras for frequency domain fluorometry and/or phosphorimetry
US5418371A (en) * 1993-02-01 1995-05-23 Aslund; Nils R. D. Apparatus for quantitative imaging of multiple fluorophores using dual detectors
US5459300A (en) * 1993-03-03 1995-10-17 Kasman; David H. Microplate heater for providing uniform heating regardless of the geometry of the microplates
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5317485A (en) * 1993-06-04 1994-05-31 American Surgical Technologies Corporation Connector and method for coupling an end of a light-transmitting conduit
AU673765B2 (en) * 1993-07-09 1996-11-21 Microscan, Inc. Fluid dispensing apparatus and method
GB9314991D0 (en) 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
US5436718A (en) * 1993-07-30 1995-07-25 Biolumin Corporation Mutli-functional photometer with movable linkage for routing optical fibers
US5766875A (en) 1993-07-30 1998-06-16 Molecular Devices Corporation Metabolic monitoring of cells in a microplate reader
SG48813A1 (en) 1993-08-12 1998-05-18 Cytotherapeutics Inc Improved composition and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
US5537343A (en) * 1993-09-02 1996-07-16 Elonex Technologies, Inc. Digital assistant system having a host computer with a docking bay and a moveable heat sink for cooling a docked module
US5541113A (en) 1993-09-22 1996-07-30 Beckman Instruments, Inc. Method for detecting an analyte using an electrochemical luminescent transition metal label
JPH07113872A (en) * 1993-10-13 1995-05-02 Shigeo Baba Method and apparatus for measuring beta emitter
SE502568C2 (en) * 1993-12-17 1995-11-13 Stemu Ab Method and apparatus for collecting fluid samples
FI96452C (en) 1994-01-26 1996-06-25 Pekka Haenninen Method for excitation of dyes
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5491343A (en) * 1994-03-25 1996-02-13 Brooker; Gary High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy
US5487872A (en) * 1994-04-15 1996-01-30 Molecular Device Corporation Ultraviolet radiation transparent multi-assay plates
US5557398A (en) * 1994-04-15 1996-09-17 Molecular Devices Corporation Photometric device
US5547861A (en) * 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5959738A (en) 1994-07-25 1999-09-28 Molecular Devices Corporation Determination of light absorption pathlength in a vertical-beam photometer
US5750410A (en) 1994-08-26 1998-05-12 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of and apparatus for immune analysis
US5589351A (en) * 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
JP3794703B2 (en) 1994-12-08 2006-07-12 アマシャム・バイオサイエンス・(エスブイ)・コーポレイション Fluorescence imaging system using macro scanning objective lens
US5592289A (en) * 1995-01-09 1997-01-07 Molecular Dynamics Self-aligning mechanism for positioning analyte receptacles
US5528146A (en) 1995-01-31 1996-06-18 The University Of Washington Method and apparatus for detecting electron spin transitions in zero field
JPH08296784A (en) * 1995-04-27 1996-11-12 Shinmei Sangyo:Kk Flexible cut-off joint for sewerage manhole
US5595710A (en) * 1995-05-25 1997-01-21 Intelligent Medical Imaging, Inc. Medical slide holder
US5604130A (en) * 1995-05-31 1997-02-18 Chiron Corporation Releasable multiwell plate cover
US5567302A (en) 1995-06-07 1996-10-22 Molecular Devices Corporation Electrochemical system for rapid detection of biochemical agents that catalyze a redox potential change
US5650832A (en) * 1995-06-13 1997-07-22 Texas Instruments Incorporated Multimode color wheel for display device
US5620894A (en) * 1995-06-16 1997-04-15 Glaxo Wellcome Inc. Apparatus for automated biological cell harvesting
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5679310A (en) 1995-07-11 1997-10-21 Polyfiltronics, Inc. High surface area multiwell test plate
US5663545A (en) 1995-08-23 1997-09-02 Ljl Biosystems Inc. Labware identification system
US5633724A (en) 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US5905571A (en) 1995-08-30 1999-05-18 Sandia Corporation Optical apparatus for forming correlation spectrometers and optical processors
FI954512A0 (en) 1995-09-22 1995-09-22 Labsystems Oy Plattbaerare
US5641633A (en) 1995-11-15 1997-06-24 Becton, Dickinson And Company Fluorescence polarization detection of nucleic acids
US5670375A (en) 1996-02-21 1997-09-23 Biomerieux Vitek, Inc. Sample card transport method for biological sample testing machine
JP2935973B2 (en) * 1996-03-01 1999-08-16 月岡 康信 Blood and other testing equipment
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
AT1406U1 (en) 1996-05-31 1997-04-25 Slt Labinstruments Gmbh FLUOROMETER
US5780857A (en) 1996-10-04 1998-07-14 Wallac Oy Apparatus for imaging biochemical samples on substrates
DE19704732A1 (en) 1997-02-07 1998-08-13 Stratec Elektronik Gmbh Luminescence measurement device
US6020591A (en) 1997-07-11 2000-02-01 Imra America, Inc. Two-photon microscopy with plane wave illumination
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
JPH1189559A (en) * 1997-09-25 1999-04-06 Matsushita Electric Ind Co Ltd Incubator
JPH11121577A (en) * 1997-10-08 1999-04-30 Mecs Corp Inspection system for semiconductor wafer
EP0977037B1 (en) 1998-07-31 2005-08-31 Tecan Trading AG Magnetic separator
EP0993916B1 (en) 1998-10-15 2004-02-25 Tecan Trading AG Robot gripper
EP0995555A1 (en) 1998-10-15 2000-04-26 Tecan AG Robot arm
CH698240B1 (en) 1998-11-17 2009-06-30 Tecan Trading Ag A method for weighing sample tubes, feeding and workstation.

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9250131B2 (en) * 2011-01-17 2016-02-02 Ricoh Co., Ltd. Multi-imaging system with interleaved images
US20120182438A1 (en) * 2011-01-17 2012-07-19 Kathrin Berkner Multi-imaging System with Interleaved Images
US9219866B2 (en) 2013-01-07 2015-12-22 Ricoh Co., Ltd. Dynamic adjustment of multimode lightfield imaging system using exposure condition and filter position
CN104198394A (en) * 2014-09-09 2014-12-10 中国科学院电工研究所 Photoacoustic spectrometry detection device with detachable optical filter plate structure
US20180079586A1 (en) * 2015-06-05 2018-03-22 Spencer Health Solutions, Llc System and method for reliably dispensing pre-packaged pharmaceuticals
US20160355322A1 (en) * 2015-06-05 2016-12-08 Hap Innovations, Llc System and method for reliably dispensing pre-packaged pharmaceuticals
US20170003498A1 (en) * 2015-07-01 2017-01-05 Materion Corporation Unbalanced hub design
US9733469B2 (en) * 2015-07-01 2017-08-15 Materion Corporation Unbalanced hub design
WO2017019747A1 (en) * 2015-07-30 2017-02-02 Molecular Devices, Llc Optical element alignment and retention for optical instruments
US10176663B2 (en) 2016-07-06 2019-01-08 Spencer Health Solutions, Llc System and method for loading a dispensing cassette useful in a system for dispensing pre-packaged pharmaceuticals
US20180086547A1 (en) * 2016-09-23 2018-03-29 Hap Innovations, Llc System and method for reliably dispensing pre-packaged pharmaceuticals
US20220219882A1 (en) * 2016-09-23 2022-07-14 Spencer Health Solutions, Llc System and method for reliably dispensing pre-packaged pharmaceuticals
US10966908B2 (en) * 2018-09-21 2021-04-06 AGEvoluzione S.r.l.s. Dispenser of substance doses with dish for collection thereof

Also Published As

Publication number Publication date
WO1999004228A3 (en) 1999-04-01
US6187267B1 (en) 2001-02-13
US6499366B1 (en) 2002-12-31
US6159425A (en) 2000-12-12
US20010007640A1 (en) 2001-07-12
US6313960B2 (en) 2001-11-06
EP1012579A2 (en) 2000-06-28
IL134069A0 (en) 2001-04-30
WO1999004228A9 (en) 1999-07-08
WO1999004228A2 (en) 1999-01-28
JP2002509235A (en) 2002-03-26
US6033100A (en) 2000-03-07
US6025985A (en) 2000-02-15
US6071748A (en) 2000-06-06

Similar Documents

Publication Publication Date Title
US20010021074A1 (en) Optical filter holder assembly
US6002581A (en) Lap top computer system with elevating port cover
EP0017210A1 (en) Spotlight or other illuminator
US7738760B2 (en) Optical polishing fixture
US20080225294A1 (en) Apparatus for checking concentricity and method for checking same
USRE37136E1 (en) Tunable high intensity forensic light
US4443061A (en) Device for holding accessories for the lenses of apparatuses for taking photographs
NO760808L (en)
US3922794A (en) Adjustable base for mounting an optical firearm sight
KR920017065A (en) Optical disc cartridges and optical disk units
GB1219647A (en) Arrangement for use in a fully focussing x-ray spectro meter
US4817120A (en) Multichannel X-ray spectrometer
JP2001108909A (en) Holder for fixing element provided with symmetrical dovetail slit arranged outside
EP0198671B1 (en) Apparatus for cleaning a record disc
DK35594A (en) Cartridge / diskette holder, preferably for storing cassettes e.g. compact disc cassettes and PC disks
US4947505A (en) Apparatus for cleaning a record disc
US6597873B2 (en) Lens hood
CN210426773U (en) Spectrometer for astronomical telescope
CN216150310U (en) Ultraviolet curing jig
US3498720A (en) Concave grating ultraviolet vacuum spectrometer
JPS57161810A (en) Optical device
CN109397137A (en) Centring means
CN211477402U (en) Adjusting device for spectrum appearance of adjusting light reflection angle
TW202018702A (en) Disk fixing device
CN212273853U (en) Searchlight convenient to installation

Legal Events

Date Code Title Description
AS Assignment

Owner name: LJL BIOSYSTEMS, INC., CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MARQUISS. SAMUEL A.;WONG, CALVIN D.;EDWARDS, GLENN R.;AND OTHERS;REEL/FRAME:009528/0220;SIGNING DATES FROM 19980930 TO 19981012

CC Certificate of correction
CC Certificate of correction
FEPP Fee payment procedure

Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

Free format text: PAT HOLDER NO LONGER CLAIMS SMALL ENTITY STATUS, ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: STOL); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

FPAY Fee payment

Year of fee payment: 4

AS Assignment

Owner name: MOLECULAR DEVICES CORPORATION, CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:LJL BIOSYSTEMS, INC.;REEL/FRAME:017136/0046

Effective date: 20051214

AS Assignment

Owner name: MDS ANALYTICAL TECHNOLOGIES (US) INC., CALIFORNIA

Free format text: CHANGE OF NAME;ASSIGNOR:MOLECULAR DEVICES CORPORATION;REEL/FRAME:020462/0794

Effective date: 20070713

Owner name: MDS ANALYTICAL TECHNOLOGIES (US) INC.,CALIFORNIA

Free format text: CHANGE OF NAME;ASSIGNOR:MOLECULAR DEVICES CORPORATION;REEL/FRAME:020462/0794

Effective date: 20070713

FPAY Fee payment

Year of fee payment: 8

AS Assignment

Owner name: MOLECULAR DEVICES, INC.,CALIFORNIA

Free format text: CHANGE OF NAME;ASSIGNOR:MDS ANALYTICAL TECHNOLOGIES (US) INC;REEL/FRAME:024091/0148

Effective date: 20100201

Owner name: MOLECULAR DEVICES, INC., CALIFORNIA

Free format text: CHANGE OF NAME;ASSIGNOR:MDS ANALYTICAL TECHNOLOGIES (US) INC;REEL/FRAME:024091/0148

Effective date: 20100201

REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
STCH Information on status: patent discontinuation

Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362

FP Lapsed due to failure to pay maintenance fee

Effective date: 20131106