EP2308597A3 - Micro-fluidic structure and method for measuring and/or positioning a liquid volume - Google Patents

Micro-fluidic structure and method for measuring and/or positioning a liquid volume Download PDF

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Publication number
EP2308597A3
EP2308597A3 EP20100186100 EP10186100A EP2308597A3 EP 2308597 A3 EP2308597 A3 EP 2308597A3 EP 20100186100 EP20100186100 EP 20100186100 EP 10186100 A EP10186100 A EP 10186100A EP 2308597 A3 EP2308597 A3 EP 2308597A3
Authority
EP
European Patent Office
Prior art keywords
measuring
positioning
liquid
wall section
gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20100186100
Other languages
German (de)
French (fr)
Other versions
EP2308597A2 (en
EP2308597B1 (en
Inventor
Rainer Gransee
Tina Röser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Original Assignee
Institut fuer Mikrotechnik Mainz GmbH
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Publication date
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Publication of EP2308597A2 publication Critical patent/EP2308597A2/en
Publication of EP2308597A3 publication Critical patent/EP2308597A3/en
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Publication of EP2308597B1 publication Critical patent/EP2308597B1/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems

Abstract

Die Erfindung betrifft einen Abmesskanal (10) zur Verwendung in einem mikrofluidischen System, insbesondere in einem Lab-On-Chip-System, mit einem ersten Ende, an dem ein erster flüssigkeitsundurchlässiger und gasdurchlässiger Wandabschnitt (26) angeordnet ist, der einen Gasanschluss (27) bereitstellt, und einem zweiten Ende, an dem der Abmesskanal mit wenigstens einer Fluidleitung verbindbar ist und an dem ein Abtrennmittel angeordnet ist, wobei in dem Abmesskanal (10) zwischen dem Wandabschnitt (26) und dem Abtrennmittel ein definiertes Volumen eingeschlossen ist. Das Abtrennmittel ist bevorzugt als ein zweiter flüssigkeitsundurchlässiger und gasdurchlässiger Wandabschnitt (28) ausgebildet ist, der einen Gasanschluss (29) bereitstellt Die Erfindung betrifft ferner eine mikrofluidische Struktur mit mehreren Fluidleitungen und einem Ventil zum wahlweisen Verbinden und/oder Trennen der Fluidleitungen, von denen wenigstens eine in Form eines solchen Abmesskanals (10) ausgebildet ist. Die Erfindung betrifft auch ein Verfahren zum Abmessen und/oder Positionieren eines Volumens einer Flüssigkeit in einem mikrofluidischen System mittels eines solchen Abmesskanals (10).

Figure imgaf001
The invention relates to a metering channel (10) for use in a microfluidic system, in particular in a lab-on-chip system, having a first end, on which a first liquid-impermeable and gas-permeable wall section (26) is arranged, which has a gas connection (27 ) and a second end to which the metering channel is connectable to at least one fluid line and to which a separation means is arranged, wherein a defined volume is enclosed in the metering channel (10) between the wall section (26) and the separation means. The separating means is preferably designed as a second liquid-impermeable and gas-permeable wall section (28) which provides a gas connection (29). The invention further relates to a microfluidic structure with a plurality of fluid lines and a valve for selectively connecting and / or disconnecting the fluid lines, of which at least one in the form of such a Abmesskanals (10) is formed. The invention also relates to a method for measuring and / or positioning a volume of a liquid in a microfluidic system by means of such a measuring channel (10).
Figure imgaf001
EP10186100.3A 2009-10-06 2010-10-01 Micro-fluidic structure and method for measuring and/or positioning a liquid volume Active EP2308597B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE200910045404 DE102009045404B4 (en) 2009-10-06 2009-10-06 Discharge channel and microfluidic structure and method for measuring and / or positioning a volume of a liquid

Publications (3)

Publication Number Publication Date
EP2308597A2 EP2308597A2 (en) 2011-04-13
EP2308597A3 true EP2308597A3 (en) 2014-07-09
EP2308597B1 EP2308597B1 (en) 2016-12-07

Family

ID=43446596

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10186100.3A Active EP2308597B1 (en) 2009-10-06 2010-10-01 Micro-fluidic structure and method for measuring and/or positioning a liquid volume

Country Status (3)

Country Link
US (1) US8443835B2 (en)
EP (1) EP2308597B1 (en)
DE (1) DE102009045404B4 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104039453B (en) * 2011-10-24 2015-12-09 彭兴跃 A kind of microfluidic circuit chip
JP6479663B2 (en) 2012-10-08 2019-03-06 ビーエル テクノロジーズ、インコーポレイテッド Prefilled test substrate for testing LAL reactive materials, method of use and method of preparation
US9440233B2 (en) * 2013-08-09 2016-09-13 Shark Kabushiki Kaisha Microfluidic device for serial fluidic operations
DE102014105437A1 (en) 2014-04-16 2015-10-22 Amodia Bioservice Gmbh Microfluidic module and cassette for immunological and molecular diagnostics in an automated analyzer
WO2021007368A1 (en) * 2019-07-09 2021-01-14 Kryptos Biotechnologies, Inc. Microfluidic reaction vessel array with patterned films
CN111617812B (en) * 2019-10-17 2021-12-03 北京京东方健康科技有限公司 Microfluidic substrate, fluid driving method thereof and microfluidic device
DE102020211697A1 (en) * 2020-09-18 2022-03-24 Robert Bosch Gesellschaft mit beschränkter Haftung Microfluidic Device

Citations (4)

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Publication number Priority date Publication date Assignee Title
US20020029814A1 (en) * 1999-06-28 2002-03-14 Marc Unger Microfabricated elastomeric valve and pump systems
US20030005967A1 (en) * 2001-07-07 2003-01-09 Nanostream, Inc. Microfluidic metering systems and methods
US6536477B1 (en) * 2000-10-12 2003-03-25 Nanostream, Inc. Fluidic couplers and modular microfluidic systems
US20070068573A1 (en) * 2005-08-22 2007-03-29 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible

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US56321A (en) * 1866-07-10 Improved shoe for stamping machinery
US266582A (en) * 1882-10-24 William demuth
US6805841B2 (en) * 2001-05-09 2004-10-19 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Liquid pumping system
US6880576B2 (en) * 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
US7128876B2 (en) * 2001-07-17 2006-10-31 Agilent Technologies, Inc. Microdevice and method for component separation in a fluid
US7244961B2 (en) * 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
US20050266582A1 (en) * 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
US7296592B2 (en) * 2003-09-16 2007-11-20 Eksigent Technologies, Llc Composite polymer microfluidic control device
US20090165876A1 (en) * 2005-11-22 2009-07-02 Micah James Atkin Microfluidic Structures
US20080035484A1 (en) * 2006-07-10 2008-02-14 Jiaqi Wu Method and apparatus for precise selection and extraction of a focused component in isoelectric focusing performed in micro-channels
EP2055384A1 (en) * 2007-10-31 2009-05-06 Leukocare AG Device for identifying constituents in a fluid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020029814A1 (en) * 1999-06-28 2002-03-14 Marc Unger Microfabricated elastomeric valve and pump systems
US6536477B1 (en) * 2000-10-12 2003-03-25 Nanostream, Inc. Fluidic couplers and modular microfluidic systems
US20030005967A1 (en) * 2001-07-07 2003-01-09 Nanostream, Inc. Microfluidic metering systems and methods
US20070068573A1 (en) * 2005-08-22 2007-03-29 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible

Also Published As

Publication number Publication date
US20110079094A1 (en) 2011-04-07
EP2308597A2 (en) 2011-04-13
US8443835B2 (en) 2013-05-21
DE102009045404A1 (en) 2011-04-07
EP2308597B1 (en) 2016-12-07
DE102009045404B4 (en) 2012-04-19

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