EP2308296A3 - System and method for holding an organ - Google Patents

System and method for holding an organ Download PDF

Info

Publication number
EP2308296A3
EP2308296A3 EP10184021A EP10184021A EP2308296A3 EP 2308296 A3 EP2308296 A3 EP 2308296A3 EP 10184021 A EP10184021 A EP 10184021A EP 10184021 A EP10184021 A EP 10184021A EP 2308296 A3 EP2308296 A3 EP 2308296A3
Authority
EP
European Patent Office
Prior art keywords
organ
perfusion
mode
medical fluid
viability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10184021A
Other languages
German (de)
French (fr)
Other versions
EP2308296A2 (en
Inventor
Donald R. Owen
David C. Kravitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organ Recovery Systems Inc
Original Assignee
Organ Recovery Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organ Recovery Systems Inc filed Critical Organ Recovery Systems Inc
Publication of EP2308296A2 publication Critical patent/EP2308296A2/en
Publication of EP2308296A3 publication Critical patent/EP2308296A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A01N1/0273—Transport containers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts

Abstract

An organ perfusion apparatus and method for monitoring, sustaining and/or restoring the viability of the organ and for preserving the organ for storage and/or transport perfuse the organ at normothermic temperatures (normothermic perfusion mode), preferably prior to and followed by organ perfusion at hypothermic temperatures (hypothermic perfusion mode) for transport and/or storage of the organ. The restoring of organ viability is accomplished by restoring high energy nucleotide (e.g., ATP) levels in the organ, which were reduced by warm ischemia time, by perfusing the organ with a medical fluid, such as an oxygenated cross-linked haemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the normothermic perfusion mode, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir which may be used in combination with a stepping motor/cam valve which provides for perfusion pressure fine tuning, preventing overpressurization and providing emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution augmented with antioxidants, intermittently or at a slow continuous flow rate. The medical fluid may be fed into the organ by gravity from an intermediary tank which has a low pressure head so overpressurization of the organ is avoided. In either mode, preventing overpressurization prevents and/or reduces damage to the vascular endothelial lining and to the organ tissue in general. Also, viability of the organ may be automatically monitored in either mode, preferably by monitoring fluid characteristics of the medical fluid that has been perfused through the organ, such fluid characteristics being indicative of organ viability. The perfusion process can be automatically control using a control program.
EP10184021A 1998-09-29 1999-09-29 System and method for holding an organ Withdrawn EP2308296A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16212898A 1998-09-29 1998-09-29
EP06024444.9A EP1929863B1 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs
EP99949991A EP1117293B1 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP06024444.9A Division-Into EP1929863B1 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs
EP99949991.6 Division 1999-09-29
EP06024444.9 Division 2006-11-24

Publications (2)

Publication Number Publication Date
EP2308296A2 EP2308296A2 (en) 2011-04-13
EP2308296A3 true EP2308296A3 (en) 2011-08-24

Family

ID=22584276

Family Applications (4)

Application Number Title Priority Date Filing Date
EP10184021A Withdrawn EP2308296A3 (en) 1998-09-29 1999-09-29 System and method for holding an organ
EP10183951A Withdrawn EP2308295A3 (en) 1998-09-29 1999-09-29 Apparatus for transporting an organ
EP99949991A Expired - Lifetime EP1117293B1 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs
EP06024444.9A Expired - Lifetime EP1929863B1 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs

Family Applications After (3)

Application Number Title Priority Date Filing Date
EP10183951A Withdrawn EP2308295A3 (en) 1998-09-29 1999-09-29 Apparatus for transporting an organ
EP99949991A Expired - Lifetime EP1117293B1 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs
EP06024444.9A Expired - Lifetime EP1929863B1 (en) 1998-09-29 1999-09-29 Apparatus and method for maintaining and/or restoring viability of organs

Country Status (8)

Country Link
EP (4) EP2308296A3 (en)
JP (1) JP2002525290A (en)
CN (1) CN1320014A (en)
AU (1) AU6274899A (en)
CA (1) CA2342944A1 (en)
DE (1) DE69941362D1 (en)
TW (1) TW442306B (en)
WO (1) WO2000018226A2 (en)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6977140B1 (en) 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
US6673594B1 (en) * 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US8361091B2 (en) 2002-08-23 2013-01-29 Organ Recovery Systems, Inc. Cannulas, cannula mount assemblies, and clamping methods using such cannulas and cannula mount assemblies
US8741555B2 (en) 2004-05-14 2014-06-03 Organ Recovery Systems, Inc. Apparatus and method for perfusion and determining the viability of an organ
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
NZ746484A (en) 2004-10-07 2020-04-24 Transmedics Inc Systems and methods for ex-vivo organ care
NL1028848C2 (en) * 2005-04-22 2006-10-24 Doorzand Airdrive B V Device for transporting an organ.
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US10176887B1 (en) 2005-11-14 2019-01-08 Organ Recovery Systems, Inc. Ex vivo methods for drug discovery, development and testing
US8173414B2 (en) * 2007-02-08 2012-05-08 Jerome E Brisson Sulfide perfusion apparatus
CN101677526B (en) * 2007-03-01 2014-07-09 生命线科学有限公司 Perfusion regulation
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8765364B2 (en) 2007-05-18 2014-07-01 Lifeline Scientific, Inc. Ex vivo methods for validating substance testing with human organs and/or tissues
US8771930B2 (en) 2007-05-18 2014-07-08 Lifeline Scientific, Inc. Ex vivo methods for testing toxicity of substances using donated human organs or tissues
FR2919785B1 (en) 2007-08-09 2017-10-20 Hemarina Sa USE OF AN EXTRACELLULAR GLOBIN, EXTRACELLULAR GLOBIN OR EXTRACELLOUS PROTOMER FOR THE PRESERVATION OF ORGANS, TISSUES, OR CELLS OF ORGANS OR TISSUES, OR THE CULTURE OF CELLS
US8420380B2 (en) * 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
US8685709B2 (en) 2009-09-25 2014-04-01 Board Of Regents Of The University Of Texas System Fluidics based pulsatile perfusion preservation device and method
WO2012027787A1 (en) * 2010-09-01 2012-03-08 Organ Perfusion Pty Limited Perfusion composition
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
EP2685814B1 (en) 2011-03-15 2016-08-17 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
ES2913104T3 (en) 2011-04-14 2022-05-31 Transmedics Inc Organ care solution for ex-vivo machine perfusion of donor lungs
US9022978B2 (en) 2011-04-29 2015-05-05 Lifeline Scientific, Inc. Universal sealring cannula
US8828034B2 (en) 2011-04-29 2014-09-09 Lifeline Scientific, Inc. Cannula
US9642625B2 (en) 2011-04-29 2017-05-09 Lifeline Scientific, Inc. Cannula for a donor organ with or without an aortic cuff or patch
US20140017666A1 (en) * 2012-07-10 2014-01-16 Lifeline Scientific, Inc. Filtration in organ perfusion apparatus
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
CA2942714C (en) 2014-03-14 2023-09-05 The General Hospital Corporation Lung bioreactor
CN113229273B (en) * 2014-03-26 2023-01-31 体沃索股份有限公司 Device for maintaining harvested heart to be transplanted
IL310657A (en) 2014-06-02 2024-04-01 Transmedics Inc Ex vivo organ care system
CA3217634A1 (en) 2014-09-02 2016-03-10 United Therapeutics Corporation Automated bioreactor system, system for automatically implementing protocol for decellularizing organ, and waste decontamination system
USD765874S1 (en) 2014-10-10 2016-09-06 Paragonix Technologies, Inc. Transporter for a tissue transport system
CN105532638B (en) * 2014-10-28 2017-10-13 孙文全 A kind of apparatus for Cord blood biomaterial
WO2016090498A1 (en) 2014-12-12 2016-06-16 Freed Darren Apparatus and method for organ perfusion
EP3249039A1 (en) * 2016-05-25 2017-11-29 Université Catholique De Louvain Perfusion-bioreactor and method for processing vascularized composite tissue
CN106508890A (en) * 2016-10-28 2017-03-22 中山大学附属第医院 Multiple organ storage device
AU2018247584A1 (en) * 2017-04-04 2019-11-21 Universidade De São Paulo Apparatus and methods for irradiating organ perfusates
EP3634127A4 (en) 2017-06-07 2021-03-17 Paragonix Technologies Inc. Apparatus for tissue transport and preservation
MX2021012242A (en) * 2019-04-12 2021-12-10 Uglx Res Ab Method and apparatus for reconditioning organs.
AU2020270928A1 (en) * 2019-04-12 2021-10-21 Uglk Science Ab Method and apparatus for reconditioning kidneys
JP2021011451A (en) * 2019-07-08 2021-02-04 株式会社Ｓｃｒｅｅｎホールディングス Perfusion device
KR20220061129A (en) * 2019-08-15 2022-05-12 아이아이실드 피티와이 엘티디 Insulated medical device to protect the graft material for transplantation
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
IL304985A (en) * 2020-02-20 2023-10-01 Deka Products Lp System and method for organ maintenance and transport
US20210289771A1 (en) * 2020-03-20 2021-09-23 The Cleveland Clinic Foundation Portable, ex vivo, normothermic limb perfusion machine
CN111937861B (en) * 2020-08-17 2021-10-26 南昌大学第二附属医院 Sevoflurane ischemia reperfusion device and using method
CN113396898B (en) 2021-08-02 2021-11-09 中山大学附属第一医院 Organ perfusion device and method without interrupting blood flow

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186565A (en) * 1978-05-19 1980-02-05 Henry Ford Hospital Perfusion system for organ preservation
EP0376763A2 (en) * 1988-10-26 1990-07-04 McKelvey, Karen A device for transportation of human organs used for transplantation
WO1991014364A1 (en) * 1990-03-28 1991-10-03 Waters Instruments, Inc. Microperfusion apparatus
US5157930A (en) * 1991-04-22 1992-10-27 Mcghee Samuel C Organ preservation apparatus
US5476763A (en) * 1990-09-28 1995-12-19 Electrolux S.A.R.L. Medical transport assembly
WO1996029865A1 (en) * 1995-03-27 1996-10-03 Organ, Inc. Organ evaluation and resuscitation device and method
WO1996030111A1 (en) * 1995-03-27 1996-10-03 Organ, Inc. Portable device for preserving organs by static storage or perfusion
WO1996041525A2 (en) * 1995-06-07 1996-12-27 The American National Red Cross Computer controlled cryoprotectant perfusion apparatus

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE755423A (en) 1969-10-06 1971-02-01 Baxter Laboratories Inc PROCESS AND APPARATUS FOR ORGAN PRESERVATION
US3892628A (en) 1969-10-06 1975-07-01 Baxter Laboratories Inc Preservation of organs
US3881990A (en) * 1971-11-24 1975-05-06 Waters Instr Inc Method of transporting and storing organs while retaining the organs in a viable condition
US3931898A (en) 1974-01-21 1976-01-13 Karnobatsky Eduard Konstantino Machine for conditioning ore heat-treating furnace throat
US3944398A (en) 1974-04-30 1976-03-16 Frank Rutherford Bell Method of forming an abrasive compact of cubic boron nitride
US3995444A (en) 1974-11-08 1976-12-07 American Hospital Supply Corporation Organ perfusion system
US4231354A (en) * 1978-07-14 1980-11-04 Howmedica, Incorporated Pulsatile blood pumping apparatus and method
US4629686A (en) 1982-02-19 1986-12-16 Endotronics, Inc. Apparatus for delivering a controlled dosage of a chemical substance
US4473637A (en) * 1982-11-10 1984-09-25 Guibert, Colman & Associates System for processing an organ preparatory to transplant
SE8403912D0 (en) * 1984-07-30 1984-07-30 Pharmacia Ab PHARMACEUTICAL KIT OR COMPOSITION
FR2592306A1 (en) * 1985-12-30 1987-07-03 Couegnas Jacques Perfusion apparatus with adjustable flow rate causing no change in the perfused liquid
US4745759A (en) 1986-12-23 1988-05-24 Bauer Dan O Kidney preservation machine
WO1988005261A1 (en) * 1987-01-16 1988-07-28 Tops Systems, Inc. Total organ perfusion system
US5051352A (en) * 1987-10-07 1991-09-24 The Regents Of The University Of California Apparatus and method of preserving the viability of animal organs
US5326706A (en) * 1989-07-17 1994-07-05 Research Foundation Of State University Of New York Homeostatic organ preservation system
JPH0653160B2 (en) * 1989-08-18 1994-07-20 呉羽化学工業株式会社 Beat generation method and device
AU7175591A (en) * 1989-12-21 1991-07-24 Regents Of The University Of California, The Novel and improved technology for preservation of organs for transplantation
US5066578A (en) 1989-12-21 1991-11-19 The Regents Of The University Of California Long-term preservation of organs for transplantation
US5395314A (en) 1990-10-10 1995-03-07 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5149321A (en) 1990-10-10 1992-09-22 Klatz Ronald M Brain resuscitation device and method for performing the same
US5584804A (en) 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5217860A (en) 1991-07-08 1993-06-08 The American National Red Cross Method for preserving organs for transplantation by vitrification
US6144916A (en) * 1992-05-15 2000-11-07 Micron Communications, Inc. Itinerary monitoring system for storing a plurality of itinerary data points
US5338662A (en) * 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US5599659A (en) 1993-03-11 1997-02-04 Breonics, Inc. Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate
WO1995031897A1 (en) * 1994-05-20 1995-11-30 Vec Tec, Inc. Method and apparatus monitoring viability of transplantable organs
US5767804A (en) * 1995-06-15 1998-06-16 Trimble Navigation Limited Integrated radio direction finding and GPS receiver tracking system
US5843024A (en) * 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US5965433A (en) * 1996-05-29 1999-10-12 Trans D.A.T.A. Service, Inc. Portable perfusion/oxygenation module having mechanically linked dual pumps and mechanically actuated flow control for pulsatile cycling of oxygenated perfusate
US5716378A (en) * 1996-06-06 1998-02-10 Medtronic, Inc. Heart preservation and transportation apparatus and method employing low rate cardiac pacing for improved removal of catabolites from the myocardium
DK1017274T3 (en) * 1997-09-23 2004-03-22 Waleed H Hassanein Compositions, methods and devices for maintaining an organ
US6209343B1 (en) * 1998-09-29 2001-04-03 Life Science Holdings, Inc. Portable apparatus for storing and/or transporting biological samples, tissues and/or organs

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186565A (en) * 1978-05-19 1980-02-05 Henry Ford Hospital Perfusion system for organ preservation
EP0376763A2 (en) * 1988-10-26 1990-07-04 McKelvey, Karen A device for transportation of human organs used for transplantation
WO1991014364A1 (en) * 1990-03-28 1991-10-03 Waters Instruments, Inc. Microperfusion apparatus
US5476763A (en) * 1990-09-28 1995-12-19 Electrolux S.A.R.L. Medical transport assembly
US5157930A (en) * 1991-04-22 1992-10-27 Mcghee Samuel C Organ preservation apparatus
WO1996029865A1 (en) * 1995-03-27 1996-10-03 Organ, Inc. Organ evaluation and resuscitation device and method
WO1996030111A1 (en) * 1995-03-27 1996-10-03 Organ, Inc. Portable device for preserving organs by static storage or perfusion
WO1996041525A2 (en) * 1995-06-07 1996-12-27 The American National Red Cross Computer controlled cryoprotectant perfusion apparatus

Also Published As

Publication number Publication date
WO2000018226A3 (en) 2000-05-25
EP1929863A1 (en) 2008-06-11
CN1320014A (en) 2001-10-31
EP2308295A2 (en) 2011-04-13
DE69941362D1 (en) 2009-10-15
TW442306B (en) 2001-06-23
EP2308295A3 (en) 2011-05-25
WO2000018226A2 (en) 2000-04-06
AU6274899A (en) 2000-04-17
JP2002525290A (en) 2002-08-13
EP1929863B1 (en) 2016-11-09
EP1117293B1 (en) 2009-09-02
EP2308296A2 (en) 2011-04-13
EP1117293A2 (en) 2001-07-25
CA2342944A1 (en) 2000-04-06

Similar Documents

Publication Publication Date Title
EP2308296A3 (en) System and method for holding an organ
EP2301342A3 (en) Method for controlling operation of a transporter
US6977140B1 (en) Method for maintaining and/or restoring viability of organs
EP0232672B1 (en) A method for preservation and storage of viable biological materials at cryogenic temperatures
CA1200507A (en) Method of preserving organ and apparatus for preserving the same
EP2038402B1 (en) Systems and methods for cryopreservation of cells
CA2638162A1 (en) Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant
EP1773117A1 (en) Delivery of high cell mass in a syringe and related methods of cryopreserving cells
EP0347923A1 (en) Portable pulsatile organ perfusion device and method
JP2015224211A (en) Non-freezing preservation transportation apparatus for biocomponent
JP2015224210A (en) Hon-freezing preservation transportation method of biocomponent
JPS6156201B2 (en)
JP2638064B2 (en) Cell cryopreservation method
JP2632531B2 (en) How to preserve organs
JPS6156202B2 (en)
JPH03287501A (en) Method and device for preservation of internal organs
Muldrew et al. Mechanisms of intracellular ice formation
JPS6444395A (en) Fish hold cooling device in vessel
JPS6155881B2 (en)

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AC Divisional application: reference to earlier application

Ref document number: 1117293

Country of ref document: EP

Kind code of ref document: P

Ref document number: 1929863

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): CH DE FR GB IT LI

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): CH DE FR GB IT LI

RIC1 Information provided on ipc code assigned before grant

Ipc: A01N 1/02 20060101AFI20110718BHEP

17P Request for examination filed

Effective date: 20120224

17Q First examination report despatched

Effective date: 20170315

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20190827

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20200108