EP2090278A1 - Transfer cap - Google Patents

Transfer cap Download PDF

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Publication number
EP2090278A1
EP2090278A1 EP20090153090 EP09153090A EP2090278A1 EP 2090278 A1 EP2090278 A1 EP 2090278A1 EP 20090153090 EP20090153090 EP 20090153090 EP 09153090 A EP09153090 A EP 09153090A EP 2090278 A1 EP2090278 A1 EP 2090278A1
Authority
EP
European Patent Office
Prior art keywords
tubular
needle
transverse wall
sealing means
transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20090153090
Other languages
German (de)
French (fr)
Inventor
Pierre-André Commaret
Alain Orlu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
P2A Medical
Original Assignee
P2A Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by P2A Medical filed Critical P2A Medical
Publication of EP2090278A1 publication Critical patent/EP2090278A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means

Definitions

  • the present invention relates to a secure transfer cap, and more particularly to a transfer cap for transferring a substance, particularly a medicinal substance, contained in a perforable bottle to a perforable or cone-shaped solute bag.
  • Such transfer caps are used to improve hygiene and safety conditions when preparing a medicament from a powder contained in a perforable bottle and a solute contained in a pierceable or cone-luer bag. .
  • the substances contained in the perforable vials are potentially dangerous substances for the users or the environment. It is therefore very important to reduce the risk of contact of medical personnel with these substances, and to reduce the risk of pollution of the medical environment by these same substances.
  • transfer caps with sealing means sealingly sealing one of the first and second needle end sections before connection of the bottle to the solute bag.
  • WO 2005/055917 A1 describes for example sealing means constituted by a cap easily perforable, pre-mounted on at least one end of the hollow needle fluid passage.
  • the cap is mounted on the needle in a sealed and sliding manner.
  • the cap being very small and to be engaged on the end of the needle which also has a very small section, its assembly is delicate.
  • This cap is even dangerous for manufacturing personnel who must carry out a translational movement of the cap with one hand in a gesture against the pointed end of the needle. Such a gesture is strongly discouraged as it generates a great risk of getting stung.
  • the person responsible for mounting the cap may inadvertently engage too much or too little cap on the end of the needle: the cap is not able to ensure a satisfactory sealing function.
  • the bottom wall of the cap can be pierced without the person in charge of the assembly noticing it. And the person in charge of the assembly also has a great risk of pricking himself by pushing the cap too deeply on the needle.
  • a first problem proposed by the invention is to design a transfer cap that avoids any risk of puncture for the nursing staff, which is simple to handle and without risk of error, and which reliably prevents any risk of projection and / or contamination of the substances contained in the perforable bottle and the solute bag.
  • the present invention aims to design a transfer cap easy to manufacture, avoiding the risk of compromising the seal by false manipulation during manual assembly by manufacturing personnel, or allowing an easily automated and reliable assembly.
  • the present invention aims to design a transfer cap avoiding the risk that manufacturing personnel pricked during a manual assembly of said transfer cap.
  • the present invention aims at designing a transfer cap enabling the contents of the pierceable bottles and solute bags to be communicated in a selective manner, independently of the connection of the bottles and bags to the tubular connection section of the transfer cap. .
  • the needle being integral with a fixed transverse wall of one of the tubular bodies, and the sealing means being integral with the fixed transverse wall of the other of the tubular bodies, the assembly of the transfer cap is made by a simple approximation and interlocking of the two tubular bodies.
  • Such a movement is easy to perform and easy to automate.
  • the establishment of the sealing means is automatically, reliably and simultaneously with the nesting of the two tubular bodies.
  • one of the needle end sections protrudes into one of the tubular bodies, so that the single connection of the bottle or solute bag to the tubular section connection of said tubular body is sufficient to put in communication the contents of the bottle or the solute bag with the hollow passage of the needle.
  • sealing means whose configuration is very simple, which can be engaged over a long length of the needle to ensure a better seal.
  • the sealing means, the transverse wall carrying the sealing means and the transverse wall tubular body carrying the sealing means are formed in one piece.
  • the monobloc character of this set of elements allows a rapid manufacturing, industrial and therefore inexpensive.
  • an injection molding technique may be used.
  • the one-piece nature of the sealing means, the transverse wall carrying the sealing means and the transverse wall tubular body carrying the sealing means ensures a perfect seal between the sealing means and the transverse wall. bearing these.
  • the tubular body carrying the needle is thus rigid enough to allow the caregiver to exert a significant force on the needle and at the very least sufficient to perforate the sealing means without unnecessary effort and safely by a clean gesture and accurate.
  • the transfer cap may also comprise holding means to keep the tubular bodies nested one inside the other.
  • the transfer cap may comprise releasable locking means for selectively holding the tubular bodies in the rest position or allowing the tubular bodies to be moved to the transfer position.
  • Unlockable locking means also allow the medical staff to perform, at the desired time, the communication of the contents of the bottles and bags of solute.
  • the holding means for keeping the tubular bodies nested one inside the other may comprise at least one radial outer lug carried by the second tubular body, able to slide axially in at least one longitudinal slot of the tubular wall of the first tubular body, said longitudinal lumen being closed at both ends thereof.
  • the unlockable locking means may comprise, in the longitudinal lumen, in the vicinity of the longitudinal lumen end opposite to the first tubular connecting portion of the first tubular body, first retaining means of the radial outer lug, preferably by reversible snap.
  • Such locking means are relatively simple in design and easy to manufacture.
  • the first tubular connecting portion may comprise second retention means adapted to receive and retain the bottle, preferably by snapping.
  • FIG. 1 Three different transfer caps are shown on the Figures 1 to 3 .
  • the Figures 1 and 2 relate to a first embodiment of the invention while the figure 3 relates to a second embodiment of the invention.
  • the first embodiment has two variants illustrated respectively on the Figures 1 and 2 .
  • the difference between the variant of the figure 1 and the variant of the figure 2 is related to the type of solute bag that can be connected to the transfer cap.
  • the transfer cap 100 of the figure 1 is adapted to be connected to a pierceable solute pocket, while the transfer cap of the figure 2 is suitable for connection to a luer cone solute bag.
  • the transfer cap 100 comprises a first tubular connection section 1, comprising first receiving means 1a for connection to a perforable bottle.
  • the transfer cap 100 further comprises a second tubular connection section 2, comprising second receiving means 2a for connection to a solute bag.
  • the transfer cap 100 further comprises a hollow needle 3 for fluid passage with a first needle end portion 3a and a second needle end portion 3b for connection to the bottle on the one hand and the bag of solute on the other hand.
  • Sealing means 5 sealingly seal one of the first and second needle end sections 3a or 3b before connecting the bottle to the solute bag.
  • the first tubular connection section 1 is carried by a first tubular body 10 while the second tubular connection section 2 is carried by a second tubular body 20.
  • the needle 3 is carried by a transverse wall 4 of the second tubular body 20.
  • the needle 3 is carried by a transverse wall 4 of the first tubular body 10.
  • the needle 3 can be fixed in the transverse wall 4 by screwing, gluing, overmolding, clipping or by any other suitable fastening means to ensure a good seal.
  • the first and second tubular bodies 10 and 20 extend in a longitudinal direction II and are mounted coaxially and longitudinally sliding relative to each other.
  • the first and second tubular bodies 10 and 20 are thus movable between a rest position illustrated on the Figures 1, 2 and 3 , and an illustrated transfer position on the figures 6 and 11 .
  • the tubular connecting sections 1 and 2 are brought closer to each other.
  • the first and second tubular bodies 10 and 20 have a mutual overlap greater than the mutual overlap they have when in the rest position.
  • sealing means 5 are integral with the transverse wall 6 carried by one of the tubular bodies 10 or 20, and sealingly seal at least one needle end portion 3a or 3b in the rest position ( Figures 1 to 3 ).
  • the sealing means 5 are perforated by the needle 3 during the displacement of the tubular bodies 10 and 20 towards the transfer position ( figures 6 and 11 ).
  • the transverse wall 4 carrying the needle 3 belongs to the second tubular body 20, while the transverse wall 6 carrying the sealing means 5 belongs to the first tubular body 10.
  • the transverse wall 4 carrying the needle 3 belongs to the first tubular body 10 while the transverse wall 6 carrying the sealing means 5 belongs to the second tubular body 20.
  • the second needle end portion 3b protrudes into the second tubular body 20, so that the sole connection of the solute bag to the second tubular connecting portion is sufficient to in communication the contents of the solute bag with the hollow passage of the needle 3.
  • the first needle end section 3a protrudes into the first tubular body 10, so that the single connection of the vial to the first connecting tubular section 1 is sufficient to bring the contents of the vial into communication with the hollow passage of the needle 3.
  • the needle 3 is overmolded in the transverse wall 4.
  • the sealing means 5 are integral with the transverse wall 6 and comprise a blind sleeve 5a sealingly engaged on the first needle end portion 3a ( Figures 1 and 2 ) or on the second needle end portion 3b ( figure 3 ) in the rest position.
  • the sealing means 5, the transverse wall 6 carrying the sealing means 5, and the tubular body 10 or 20 with a transverse wall 6 carrying the sealing means 5, are formed in one piece, as can be seen especially on Figures 1 to 3 thanks to the hatching of these sectional views.
  • the one-piece character of the sealing means 5, the transverse wall 6 and the tubular body 10 or 20 allows a manufacturing by molding, plastic injection for example.
  • the sealing means 5 thus have a perfect seal with the transverse wall 6 and are positioned very precisely coaxially along the longitudinal axis I-I of the tubular body 10 or 20.
  • sealing means 5 can be attached and fixed on the transverse wall 6. Their assembly is then carried out before the interlocking first and second tubular bodies 10 and 20 and is safe for an operator.
  • the needle 3 is also positioned precisely coaxially with the axis II of the tubular body 10 or 20. As a result, the engagement of one of the first and second needle end portions 3a and 3b is easily accomplished. and automatically by assembling coaxially the first and second tubular bodies 10 and 20. The assembly is thus simple and without risk of error.
  • the second tubular body 20 with transverse wall 4 carrying the needle 3 is made of a hard plastic material, preferably of polystyrene, while the first tubular body 10 having a transverse wall 6 carrying the sealing means 5 is made of a softer plastic material, pierceable by the needle 3, polypropylene or preferably polyethylene.
  • the first tubular body 10 is made of a hard plastic material, preferably polystyrene, while the second tubular body 20 is made of a softer plastic material, pierceable by the needle 3, polypropylene or polyethylene preferably.
  • the transfer cap 100 includes holding means 7 for keeping the tubular bodies 10 and 20 nested within each other.
  • the transfer cap of the first and second embodiments further comprises releasable locking means 8 for selectively holding the tubular bodies 10 and 20 in the rest position ( figure 1 to 3 ) or allow the displacement of the tubular bodies 10 and 20 towards the transfer position ( figures 6 and 11 ).
  • the holding means 7 comprise two radial outer lugs 7a and 7b carried by the second tubular body 20.
  • the radial outer lugs 7a and 7b are able to slide axially in the longitudinal direction II in respectively longitudinal slots 70a and 70b.
  • the longitudinal slots 70a and 70b are provided in the tubular wall of the first tubular body 10 and are closed at their two ends 701a, 702a, 701b and 702b.
  • the unlocking locking means 8 comprise, in the longitudinal slots 70a and 70b, in the vicinity of the ends 701a and 701b, first retaining means 11 radial outer pins 7a-7b.
  • the ends 701a and 701b of the longitudinal slots 70a and 70b lie opposite the first tubular connection section 1 of the first tubular body 10.
  • the first retaining means 11 radial outer pins 7a and 7b are a reversible latching provided by means of transverse bars 11a and 11b.
  • first retaining means 11 with transverse bars 11a and 11b may comprise other forms of first retention means 11 as illustrated on the Figures 12 and 13 for example: on the figure 12 the end 701a of the light 70a comprises a transverse section, so that the unlocking requires a voluntary forward movement of axial rotation of the tubular bodies 10 and 20 relative to each other; on the figure 13 , the first retention means 11 are a narrowing of the longitudinal lumen 70a, which requires an additional axial force.
  • the lights 70a and 70b also comprise, in the vicinity of the ends 702a and 702b, other retaining means 11 'radial outer lugs 7a and 7b.
  • first retention means 11 for selectively maintaining the tubular bodies 10 and 20 in the rest position or allowing the displacement of the tubular bodies 10 and 20 to the transfer position, and other retention means 11 'are available for maintain the tubular bodies 10 and 20 in the transfer position.
  • the first tubular connection section 1 comprises second retention means 12 able to receive and hold the vial 16.
  • the second retention means 12 comprise one or more elastic axial rods 12a with a free end 12b and a radial pin that retracts 12c.
  • the second retention means 12 comprise three elastic axial rods 12a for receiving and retaining the bottle reliably snap.
  • the mounting method of the transfer caps according to the invention is simple and without risk of error.
  • the first tubular body 10 and the second tubular body 20 are manufactured independently.
  • the tubular bodies 10 and 20 are then positioned coaxially with the first and second connecting tubular sections 1 and 2 oriented one away from the other ( figure 14 ).
  • the first and second tubular bodies 10 and 20 are then brought closer to each other in a movement illustrated by the arrows 13a and 13b.
  • the end portion 14 of the first tubular body 10 is slightly deformed by flaring to receive the end 15 of the second tubular body 20 and the radial lugs 7a and 7b ( figure 15 ).
  • the end 15 is the end of the second tubular body 20 opposite to the second tubular connecting portion 2, while the end 14 is the end of the first tubular body 10 opposite to the first tubular connecting portion 1.
  • the second tubular body 20 is made of a hard plastic material, preferably polystyrene, while the first tubular body 10 is made of a softer plastic material, polypropylene or polyethylene. preference.
  • the tubular body 10 is made of a hard plastic material, preferably polystyrene, while the tubular body 20 is made of a softer plastic material, polypropylene or preferably polyethylene.
  • the person in charge of the assembly continues the relative movement of the tubular bodies 10 and 20 illustrated by the arrows 13a and 13b, until bringing the radial lugs 7a and 7b into the locking means 8 provided at the ends 701a and 701 b lights 70a and 70b.
  • the assembly of the transfer cap is then completed and the tubular bodies 10 and 20 are arranged in the rest position with the first or second end portions 3a or 3b of the needle 3 sealingly engaged in the sealing means. sealing 5.
  • the user grasps a transfer cap 100 in the rest position and connects a flask 16 with a pierceable lid 16a to the first tubular connection section 1.
  • This connection can be carried out either by engaging the pierceable lid end 16a of the bottle 16 in the first tubular connection section 1 while the user holds the transfer cap 100 by the first tubular body 10, or by bringing the transfer cap 100 onto the pierceable lid end 16a of the bottle 16, the user holding the transfer cap 100 by the single first tubular body 10. In this state, the solute bag 17 is away from the transfer cap 100.
  • the user then reports a pierceable solute bag 17 with a pierceable tip 17a, by engaging the pierceable tip 17a in the second tubular connection section 2 in a movement illustrated by the arrow 18, the transfer cap 100 remaining in the position of rest.
  • the contents of the pierceable solute bag 17 are then placed in communication with the hollow passage of the needle 3 but can not flow, the first needle end portion 3a being engaged in the blind sleeve 5a so that waterproof.
  • Locking means 8 are chosen which are able to prevent the tubular bodies 10 from sliding relative to one another before the pierceable tip 17a is perforated by the needle 3.
  • the radial outer lugs 7a and 7b cause the radial deformation of the transverse bars 11a and 11b of the first retention means 11.
  • the transverse bars 11a and 11b are indeed made of a plastic material soft and are therefore deformable.
  • the first and second tubular bodies 10 and 20 After radially deforming the transverse bars 11a and 11b by the oblique respective leading faces 19a and 19b, the first and second tubular bodies 10 and 20 can move freely to come into the transfer position.
  • the first end portion 3a of the needle 3 perforates the bottom wall 50a of the blind sleeve 5a and the perforable lid 16a of the bottle 16. It is then in the position illustrated on the figure 6 , which is the transfer position.
  • the figure 8 is a sectional view illustrating the use of the transfer cap of the figure 2 .
  • this transfer cap is similar to that of the transfer cap of the figure 1 and differs therefrom only in connection with the solute bag 170 which is a luer cone solute bag 170a.
  • the user screws the luer tip 170a into the second connecting tubular section 2 of the second tubular body 20.
  • the first tubular connection section 1 has an internal diameter d1 greater than the internal diameter d2 of the second connecting tubular section 2.
  • the tips 17a and 170a of the solute bags 17 and 170 allow the use of a diameter d2 sufficiently weak to prevent the penetration of a finger of a user in the second connecting tubular section 2. There is therefore no risk to leave the second unprotected needle end portion 3b.
  • the diameter d1 must allow the connection of the perforable bottle 16, and it is therefore generally large enough for a user to accidentally engage a finger in the first tubular connecting portion 1.
  • the sleeve 5a is used to wrap the second needle end portion 3b so that there is no risk for a user to prick, even if it inadvertently engages his finger in the first connecting tubular section 1 when the transfer cap and in the rest position.
  • the user connects the bottle 16 to the first tubular connecting section 1 ( figure 9 ).
  • the second needle end portion 3b protruding into the tubular body 10 pierces the pierceable lid 16a.
  • the contents of the bottle 16 are then placed in communication with the hollow passage of the needle 3.
  • the user then reports the solute bag 17 with pierceable tip 17a by engaging the pierceable tip 17a in the second tubular connection section 2 (FIG. figure 10 ) in a movement illustrated by the arrow 18.
  • the nursing staff selects the moment when it puts in communication the inner cavities of the pockets 17 or 170 and the vial 16 by a simple gesture, without risk of error, the displacement of the tubular bodies 10 and 20, in the transfer position can be caused only by a deliberate and deliberate action on the part of the user.
  • the projection phenomenon does not occur during the piercing of the perforable seal 16a of the vial 16, the second end of the needle end 3b being sealingly engaged in the sleeve 5a of the sealing means 5.
  • the phenomenon of projection can occur only when the needle 3 has penetrated into the pierceable tip 17a according to its second end portion 3b.
  • the user can not in any case be directly exposed to the projection phenomenon, the latter necessarily being confined in the solute bag 17 or 170.

Abstract

The closure (100) has two tubular connection sections (1, 2) respectively carried by tubular bodies (10, 20) and displaceable between a rest position and a transfer position in which the connection sections are close to each other. Sealing units (5) close one of the end sections (3a, 3b) of a needle (3) in sealed manner in the rest position, and are integrated to a transverse wall (6) carried by one of the bodies, where the needle is fixed in a transverse wall (4) of the other body. The sealing units are perforated by the needle during displacement of the bodies towards the transfer position.

Description

La présente invention concerne un capuchon de transfert sécurisé, et plus particulièrement un capuchon de transfert pour transférer vers une poche de soluté perforable ou à cône luer une substance, notamment médicamenteuse, contenue dans un flacon perforable.The present invention relates to a secure transfer cap, and more particularly to a transfer cap for transferring a substance, particularly a medicinal substance, contained in a perforable bottle to a perforable or cone-shaped solute bag.

Il existe de nombreux types de capuchons de transfert, ceux-ci comprenant généralement :

  • un premier tronçon tubulaire de connexion, comportant des premiers moyens de réception pour la connexion au flacon perforable,
  • un second tronçon tubulaire de connexion, comportant des seconds moyens de réception pour la connexion à la poche de soluté,
  • une aiguille creuse de perforation et de passage de fluide à premier et second tronçons d'extrémité d'aiguille pour la connexion au flacon d'une part et à la poche de soluté d'autre part, portée par une paroi transversale d'un corps tubulaire.
There are many types of transfer caps, these typically include:
  • a first tubular connecting section, comprising first receiving means for connecting to the perforable bottle,
  • a second tubular connecting section, comprising second receiving means for connection to the solute bag,
  • a hollow needle for perforation and fluid passage at first and second needle end sections for connection to the bottle on the one hand and the solute bag on the other hand, carried by a transverse wall of a body tubular.

De tels capuchons de transfert sont utilisés pour améliorer les conditions d'hygiène et de sécurité lors de la préparation d'un médicament à partir d'une poudre contenue dans un flacon perforable et d'un soluté contenu dans une poche perforable ou à cône luer.Such transfer caps are used to improve hygiene and safety conditions when preparing a medicament from a powder contained in a perforable bottle and a solute contained in a pierceable or cone-luer bag. .

Il faut en effet éviter si possible la contamination de l'un des contenus de la poche de soluté ou du flacon perforable, tout en réduisant les risques que le personnel médical se pique avec l'aiguille creuse de passage de fluide.If possible, contamination of one of the contents of the solute bag or perforable bottle must be avoided, while reducing the risk of medical personnel pricking themselves with the hollow needle for the passage of fluid.

Les substances contenues dans les flacons perforables sont des substances potentiellement dangereuses pour les utilisateurs ou l'environnement. Il est donc très important de réduire les risques de contact du personnel médical avec ces substances, et de réduire les risques de pollution de l'environnement médical par ces mêmes substances.The substances contained in the perforable vials are potentially dangerous substances for the users or the environment. It is therefore very important to reduce the risk of contact of medical personnel with these substances, and to reduce the risk of pollution of the medical environment by these same substances.

Cependant, lors de manipulations de ces flacons perforables, on a pu certaines fois constater, lors du perçage du flacon perforable par l'aiguille creuse, un phénomène de projection de la substance médicamenteuse contenue dans le flacon perforable via l'aiguille creuse de passage de fluide, projection vraisemblablement provoquée par une différence de pression entre l'intérieur du flacon et l'environnement extérieur. La substance médicamenteuse a pu alors en partie se répandre dans l'environnement extérieur, être projetée sur les mains du personnel médical, voire être inhalée par celui-ci.However, during handling of these perforable vials, it was sometimes possible to observe, during the piercing of the pierceable bottle by the hollow needle, a phenomenon of projection of the medicinal substance contained in the perforable bottle via the hollow needle passing through. fluid, projection presumably caused by a pressure difference between the inside of the bottle and the external environment. The drug substance could then partly spread into the external environment, be projected onto the hands of medical personnel, or even be inhaled by it.

On a ainsi prévu des capuchons de transfert à moyens d'étanchéité, obturant de façon étanche l'un des premier et second tronçons d'extrémité d'aiguille avant connexion du flacon à la poche de soluté.There are thus provided transfer caps with sealing means sealingly sealing one of the first and second needle end sections before connection of the bottle to the solute bag.

Le document WO 2005/055917 A1 décrit par exemple des moyens d'étanchéité constitués par un capuchon facilement perforable, pré-monté sur au moins l'une des extrémités de l'aiguille creuse de passage de fluide. Le capuchon est monté sur l'aiguille de manière étanche et coulissante.The document WO 2005/055917 A1 describes for example sealing means constituted by a cap easily perforable, pre-mounted on at least one end of the hollow needle fluid passage. The cap is mounted on the needle in a sealed and sliding manner.

Le capuchon étant de très petite taille et devant être engagé sur l'extrémité de l'aiguille qui présente elle aussi une section très réduite, son montage s'avère délicat.The cap being very small and to be engaged on the end of the needle which also has a very small section, its assembly is delicate.

Le montage de ce capuchon s'avère même dangereux pour le personnel de fabrication qui doit effectuer un mouvement de translation du capuchon avec une main selon un geste allant à l'encontre de l'extrémité pointue de l'aiguille. Un tel geste est fortement déconseillé car il génère un grand risque de se piquer.The mounting of this cap is even dangerous for manufacturing personnel who must carry out a translational movement of the cap with one hand in a gesture against the pointed end of the needle. Such a gesture is strongly discouraged as it generates a great risk of getting stung.

En outre, la personne chargée du montage du capuchon peut malencontreusement engager trop ou trop peu le capuchon sur l'extrémité de l'aiguille : le capuchon n'est alors pas capable d'assurer une fonction d'étanchéité satisfaisante.In addition, the person responsible for mounting the cap may inadvertently engage too much or too little cap on the end of the needle: the cap is not able to ensure a satisfactory sealing function.

Lorsque le capuchon est trop engagé sur l'aiguille, la paroi de fond du capuchon peut être percée sans que la personne chargée du montage ne s'en aperçoive. Et la personne chargée du montage a également un grand risque de se piquer en enfonçant trop profondément le capuchon sur l'aiguille.When the cap is too engaged on the needle, the bottom wall of the cap can be pierced without the person in charge of the assembly noticing it. And the person in charge of the assembly also has a great risk of pricking himself by pushing the cap too deeply on the needle.

Enfin, toutes ces opérations de montage du capuchon ne peuvent être réalisées que manuellement, du fait de la précision qu'elles requièrent. Cela augmente le coût de fabrication du capuchon de transfert de façon très importante, pour une fiabilité d'étanchéité qui n'est même pas certaine.Finally, all these cap mounting operations can be performed only manually, because of the accuracy they require. This increases the manufacturing cost of the transfer cap in a very important way, for sealing reliability that is not even certain.

Dans les documents US 4,898,209 et FR 2 856 660 , il est décrit des moyens d'étanchéité destinés à être introduits dans le tronçon tubulaire de connexion au flacon après que des premier et second corps tubulaires aient été assemblés par emboîtement. Il y a un risque important pour l'opérateur de se piquer accidentellement ou d'endommager les moyens d'étanchéité lors de leur montage qui s'effectue par un geste allant directement à l'encontre d'une extrémité pointue de l'aiguille.In documents US 4,898,209 and FR 2,856,660 , there is disclosed sealing means for introduction into the tubular connecting section to the bottle after first and second tubular bodies have been assembled by interlocking. There is a significant risk for the operator to accidentally prick or damage the sealing means during their assembly which is effected by a gesture going directly against a sharp end of the needle.

Le document US 6,022,339 décrit un capuchon de transfert onéreux à fabriquer car comportant un grand nombre d'éléments constitutifs. Le trop grand nombre d'éléments constitutifs complique et augmente les risques de son assemblage, et ce d'autant plus que l'aiguille est fixée dans un porte-aiguille qui est mobile, déplaçable en translation, par rapport aux deux corps tubulaires principaux constituant le capuchon de transfert. Ce caractère mobile du porte-aiguille oblige à un percement simultané de la poche de soluté et du flacon perforable.The document US 6,022,339 describes an expensive transfer cap to manufacture because having a large number of constituent elements. The excessive number of constituent elements complicates and increases the risks of its assembly, and all the more so as the needle is fixed in a needle holder which is movable, displaceable in translation, with respect to the two main tubular bodies constituting the transfer cap. This movable nature of the needle holder forces a simultaneous piercing of the solute bag and the perforable bottle.

Un premier problème proposé par l'invention est de concevoir un capuchon de transfert qui évite tout risque de piqûre pour le personnel soignant, qui est simple à manipuler et sans risque d'erreur, et qui empêche de façon fiable tout risque de projection et/ou de contamination des substances contenues dans le flacon perforable et la poche de soluté.A first problem proposed by the invention is to design a transfer cap that avoids any risk of puncture for the nursing staff, which is simple to handle and without risk of error, and which reliably prevents any risk of projection and / or contamination of the substances contained in the perforable bottle and the solute bag.

Simultanément, la présente invention vise à concevoir un capuchon de transfert facile à fabriquer, évitant le risque de compromettre l'étanchéité par une fausse manipulation lors d'un assemblage manuel par du personnel de fabrication, ou permettant un montage facilement automatisable et fiable.Simultaneously, the present invention aims to design a transfer cap easy to manufacture, avoiding the risk of compromising the seal by false manipulation during manual assembly by manufacturing personnel, or allowing an easily automated and reliable assembly.

Simultanément, la présente invention vise à concevoir un capuchon de transfert évitant le risque que le personnel de fabrication se pique lors d'un assemblage manuel dudit capuchon de transfert.Simultaneously, the present invention aims to design a transfer cap avoiding the risk that manufacturing personnel pricked during a manual assembly of said transfer cap.

Selon un autre aspect, la présente invention vise à concevoir un capuchon de transfert permettant la mise en communication des contenus des flacons perforables et poches de soluté de façon sélective, indépendamment de la connexion des flacons et poches au tronçon tubulaire de connexion du capuchon de transfert.According to another aspect, the present invention aims at designing a transfer cap enabling the contents of the pierceable bottles and solute bags to be communicated in a selective manner, independently of the connection of the bottles and bags to the tubular connection section of the transfer cap. .

Pour atteindre ces objets ainsi que d'autres, l'invention propose un capuchon de transfert pour transférer vers une poche de soluté perforable ou à cône luer une substance, notamment médicamenteuse, contenue dans un flacon perforable, comprenant :

  • un premier tronçon tubulaire de connexion, comportant des premiers moyens de réception pour la connexion au flacon perforable,
  • un second tronçon tubulaire de connexion, comportant des seconds moyens de réception pour la connexion à la poche de soluté,
  • une aiguille creuse de passage de fluide à premier et second tronçons d'extrémité d'aiguille pour la connexion au flacon d'une part et à la poche de soluté d'autre part, portée par une paroi transversale d'un corps tubulaire longitudinal,
  • des moyens d'étanchéité, obturant de façon étanche l'un des premier et second tronçons d'extrémité d'aiguille avant connexion du flacon à la poche de soluté,
dans lequel :
  • les premier et second tronçons tubulaires de connexion sont portés respectivement par des premier et second corps tubulaires distincts montés coaxialement et à coulissement longitudinal l'un par rapport à l'autre, et déplaçables entre une position de repos et une position de transfert dans laquelle les tronçons tubulaires de connexion sont rapprochés l'un de l'autre,
  • les moyens d'étanchéité sont solidaires d'une paroi transversale portée par l'un des corps tubulaires, et obturent de façon étanche ledit au moins un tronçon d'extrémité d'aiguille en position de repos,
  • les moyens d'étanchéité sont perforés par l'aiguille lors du déplacement des corps tubulaires vers la position de transfert ;
selon l'invention :
  • l'aiguille est fixée dans la paroi transversale de l'un des corps tubulaires,
  • les moyens d'étanchéité sont solidaires de la paroi transversale de l'autre des corps tubulaires.
To achieve these objects as well as others, the invention proposes a transfer cap for transferring to a perforable solute bag or cone luer a substance, especially drug, contained in a perforable bottle, comprising:
  • a first tubular connecting section, comprising first receiving means for connecting to the perforable bottle,
  • a second tubular connecting section, comprising second receiving means for connection to the solute bag,
  • a hollow needle for fluid passage at first and second needle end sections for connection to the bottle on the one hand and to the solute bag on the other hand, carried by a transverse wall of a longitudinal tubular body,
  • sealing means, sealingly sealing one of the first and second needle end sections before connecting the bottle to the solute bag,
in which :
  • the first and second tubular connection sections are carried respectively by first and second separate tubular bodies coaxially mounted and longitudinally sliding relative to one another, and movable between a rest position and a transfer position in which the tubular connection sections are brought closer to one another,
  • the sealing means are integral with a transverse wall carried by one of the tubular bodies, and sealingly seal said at least one end portion of the needle in the rest position,
  • the sealing means are perforated by the needle during the displacement of the tubular bodies to the transfer position;
according to the invention:
  • the needle is fixed in the transverse wall of one of the tubular bodies,
  • the sealing means are integral with the transverse wall of the other of the tubular bodies.

Un tel dispositif permet d'apporter avec succès une solution simple et efficace aux problèmes mentionnés ci-dessus.Such a device makes it possible to successfully bring a simple and effective solution to the problems mentioned above.

L'aiguille étant solidaire d'une paroi transversale fixe de l'un des corps tubulaires, et les moyens d'étanchéité étant solidaires de la paroi transversale fixe de l'autre des corps tubulaires, l'assemblage du capuchon de transfert se fait par un simple rapprochement et emboîtement des deux corps tubulaires. Un tel mouvement est facile à réaliser et facile à automatiser. La mise en place des moyens d'étanchéité se fait automatiquement, de façon fiable et simultanément à l'emboîtement des deux corps tubulaires. Il n'y a pas de risque de détérioration accidentelle des moyens d'étanchéité par l'aiguille par un mauvais positionnement relatif de ceux-ci lors de l'assemblage : leur positionnement relatif est effectué avec précision par la coopération mutuelle des deux corps tubulaires qui s'emboîtent coaxialement.The needle being integral with a fixed transverse wall of one of the tubular bodies, and the sealing means being integral with the fixed transverse wall of the other of the tubular bodies, the assembly of the transfer cap is made by a simple approximation and interlocking of the two tubular bodies. Such a movement is easy to perform and easy to automate. The establishment of the sealing means is automatically, reliably and simultaneously with the nesting of the two tubular bodies. There is no risk of accidental deterioration of the sealing means by the needle by a relative poor positioning of the latter during assembly: their relative positioning is carried out with precision by the mutual cooperation of the two tubular bodies which fit together coaxially.

Dans le cas d'un montage manuel, le risque pour l'opérateur de se piquer par mégarde est très réduit, voire nul.In the case of a manual assembly, the risk of the operator inadvertently prick is very small, if any.

De préférence, on peut prévoir que, en position de repos, l'un des tronçons d'extrémité d'aiguille dépasse dans l'un des corps tubulaires, de sorte que la seule connexion du flacon ou de la poche de soluté au tronçon tubulaire de connexion dudit corps tubulaire suffit à mettre en communication le contenu du flacon ou de la poche de soluté avec le passage creux de l'aiguille.Preferably, it can be provided that, in the rest position, one of the needle end sections protrudes into one of the tubular bodies, so that the single connection of the bottle or solute bag to the tubular section connection of said tubular body is sufficient to put in communication the contents of the bottle or the solute bag with the hollow passage of the needle.

On limite ainsi le nombre de mouvements que le personnel soignant doit effectuer pour préparer la substance médicamenteuse. Le personnel soignant n'a alors en effet plus qu'à mettre en communication le contenu de l'un des flacons ou poche avec le passage creux de l'aiguille pour achever la mise en communication des contenus du flacon et de la poche.This limits the number of movements that health care personnel must perform to prepare the drug substance. The nursing staff then only has to put in communication the contents of one of the bottles or bag with the hollow passage of the needle to complete the communication between the contents of the bottle and the pocket.

De préférence, on peut prévoir que :

  • l'aiguille est surmoulée dans la paroi transversale de l'un des corps tubulaires,
  • les moyens d'étanchéité, solidaires de la paroi transversale de l'autre des corps tubulaires, comprennent un manchon borgne engagé de façon étanche sur le tronçon d'extrémité d'aiguille correspondant en position de repos.
Preferably, it can be provided that:
  • the needle is overmolded in the transverse wall of one of the tubular bodies,
  • the sealing means, integral with the transverse wall of the other of the tubular bodies, comprise a blind sleeve sealingly engaged on the corresponding needle end portion in the rest position.

On assure ainsi de façon simple une étanchéité parfaite entre l'aiguille et la paroi transversale du corps tubulaire correspondant, par un procédé de fabrication simple, rapide, économique et parfaitement automatisable.This ensures a simple and perfect sealing between the needle and the transverse wall of the corresponding tubular body, a simple manufacturing process, fast, economical and fully automated.

On dispose en outre de moyens d'étanchéité dont la configuration est très simple, qui peuvent être engagés sur une longueur importante de l'aiguille pour assurer une meilleure étanchéité.There are also sealing means whose configuration is very simple, which can be engaged over a long length of the needle to ensure a better seal.

On garantit en effet une meilleure étanchéité lorsque ceux-ci agissent sur une grande longueur de l'aiguille plutôt que sur sa seule extrémité comme dans le cas du document WO 2005/055917 A1 .In fact, a better seal is guaranteed when these act over a long length of the needle rather than at its end only as in the case of the document. WO 2005/055917 A1 .

De façon avantageuse, on peut prévoir que les moyens d'étanchéité, la paroi transversale portant les moyens d'étanchéité et le corps tubulaire à paroi transversale portant les moyens d'étanchéité sont formés d'une seule pièce.Advantageously, it can be provided that the sealing means, the transverse wall carrying the sealing means and the transverse wall tubular body carrying the sealing means are formed in one piece.

Le caractère monobloc de cet ensemble d'éléments permet une fabrication rapide, industrielle et donc peu onéreuse. On pourra par exemple avoir recours à une technique de moulage par injection.The monobloc character of this set of elements allows a rapid manufacturing, industrial and therefore inexpensive. For example, an injection molding technique may be used.

Enfin, le caractère monobloc des moyens d'étanchéité, de la paroi transversale portant les moyens d'étanchéité et du corps tubulaire à paroi transversale portant les moyens d'étanchéité permet de garantir une étanchéité parfaite entre les moyens d'étanchéité et la paroi transversale portant ceux-ci.Finally, the one-piece nature of the sealing means, the transverse wall carrying the sealing means and the transverse wall tubular body carrying the sealing means ensures a perfect seal between the sealing means and the transverse wall. bearing these.

De préférence, on peut prévoir que :

  • le corps tubulaire à paroi transversale portant l'aiguille est réalisé en une matière plastique dure, en polystyrène de préférence,
  • le corps tubulaire à paroi transversale portant les moyens d'étanchéité est réalisé en une matière plastique molle perforable par l'aiguille, en polypropylène ou en polyéthylène de préférence.
Preferably, it can be provided that:
  • the tubular body with a transverse wall carrying the needle is made of a hard plastic material, preferably of polystyrene,
  • the tubular body with transverse wall carrying the sealing means is made of a soft plastic material perforable by the needle, polypropylene or preferably polyethylene.

Le corps tubulaire portant l'aiguille est ainsi suffisamment rigide pour permettre au personnel soignant d'exercer une force importante sur l'aiguille et à tout le moins suffisante pour perforer les moyens d'étanchéité sans effort inutile et en toute sécurité par un geste net et précis.The tubular body carrying the needle is thus rigid enough to allow the caregiver to exert a significant force on the needle and at the very least sufficient to perforate the sealing means without unnecessary effort and safely by a clean gesture and accurate.

Avantageusement, le capuchon de transfert peut comprendre également des moyens de maintien pour garder les corps tubulaires emboîtés l'un dans l'autre.Advantageously, the transfer cap may also comprise holding means to keep the tubular bodies nested one inside the other.

On évite ainsi tout risque de perte de l'un des corps tubulaires. En outre, on évite tout risque de démontage intempestif des deux corps tubulaires, un tel démontage pouvant entraîner un manque d'hygiène ou de sécurité. Les éléments constitutifs du capuchon de transfert ne peuvent ainsi pas être contaminés lors d'un démontage accidentel ou intentionnel de celui-ci. Et il n'y a pas de risque d'exposer inutilement le personnel médical à une extrémité d'aiguille non protégée.This avoids any risk of loss of one of the tubular bodies. In addition, it avoids any risk of inadvertent disassembly of the two tubular bodies, such disassembly may cause a lack of hygiene or safety. The components of the transfer cap can not be contaminated during accidental or intentional disassembly thereof. And there is no risk of unnecessarily exposing medical personnel to an unprotected needle tip.

De préférence, le capuchon de transfert peut comprendre des moyens de verrouillage déverrouillables pour sélectivement maintenir les corps tubulaires en position de repos ou autoriser le déplacement des corps tubulaires vers la position de transfert.Preferably, the transfer cap may comprise releasable locking means for selectively holding the tubular bodies in the rest position or allowing the tubular bodies to be moved to the transfer position.

On évite ainsi tout risque de percement intempestif ou accidentel des moyens d'étanchéité, par inadvertance ou maladresse d'un utilisateur peu précautionneux par exemple. Les moyens d'étanchéité ne peuvent être percés que par une action franche et délibérée de l'utilisateur.This avoids any risk of inadvertent or accidental piercing means sealing, inadvertently or awkwardness of a user not very cautious for example. The sealing means can be pierced only by a frank and deliberate action of the user.

Des moyens de verrouillage déverrouillables permettent en outre au personnel médical d'effectuer, au moment où il le désire, la mise en communication des contenus des flacons et poches de soluté.Unlockable locking means also allow the medical staff to perform, at the desired time, the communication of the contents of the bottles and bags of solute.

De préférence, les moyens de maintien pour garder les corps tubulaires emboîtés l'un dans l'autre peuvent comprendre au moins un ergot extérieur radial porté par le second corps tubulaire, apte à coulisser axialement dans au moins une lumière longitudinale de la paroi tubulaire du premier corps tubulaire, ladite lumière longitudinale étant fermée à ses deux extrémités.Preferably, the holding means for keeping the tubular bodies nested one inside the other may comprise at least one radial outer lug carried by the second tubular body, able to slide axially in at least one longitudinal slot of the tubular wall of the first tubular body, said longitudinal lumen being closed at both ends thereof.

Avantageusement, les moyens de verrouillage déverrouillables peuvent comprendre, dans la lumière longitudinale, au voisinage de l'extrémité de lumière longitudinale opposée au premier tronçon tubulaire de connexion du premier corps tubulaire, des premiers moyens de rétention de l'ergot extérieur radial, de préférence par encliquetage réversible.Advantageously, the unlockable locking means may comprise, in the longitudinal lumen, in the vicinity of the longitudinal lumen end opposite to the first tubular connecting portion of the first tubular body, first retaining means of the radial outer lug, preferably by reversible snap.

De tels moyens de verrouillage sont relativement simples de conception et faciles à fabriquer.Such locking means are relatively simple in design and easy to manufacture.

De préférence, le premier tronçon tubulaire de connexion peut comporter des seconds moyens de rétention aptes à recevoir et retenir le flacon, de préférence par encliquetage.Preferably, the first tubular connecting portion may comprise second retention means adapted to receive and retain the bottle, preferably by snapping.

On permet ainsi à l'utilisateur de venir rapporter de façon fiable et sûre le capuchon de transfert sur le flacon perforable avant même la connexion de la poche de soluté sur le capuchon de transfert. On facilite ainsi grandement les manipulations du personnel, qui pourra tenir trois éléments (flacon, capuchon de transfert et poche de soluté) au moyen de ses deux seules mains.This allows the user to reliably and reliably bring the transfer cap onto the pierceable bottle even before the solute bag is connected to the transfer cap. This greatly facilitates the handling of personnel, who can hold three elements (bottle, transfer cap and solute bag) with only two hands.

En outre, on évite tout risque de déconnexion intempestive ou accidentelle du flacon au cours de la préparation de la substance médicamenteuse par mélange des substances contenues dans les flacons et poches.In addition, it avoids any risk of inadvertent or accidental disconnection of the vial during the preparation of the drug substance by mixing the substances in the vials and bags.

D'autres objets, caractéristiques et avantages de la présente invention ressortiront de la description suivante de modes de réalisation particuliers, faite en relation avec les figures jointes, parmi lesquelles :

  • la figure 1 est une vue en coupe d'une première variante d'un premier mode de réalisation de capuchon de transfert selon l'invention ;
  • la figure 2 est une vue en coupe d'une seconde variante du premier mode de réalisation de capuchon de transfert selon l'invention ;
  • la figure 3 est une vue en coupe d'un second mode de réalisation de capuchon de transfert selon l'invention ;
  • les figures 4 à 6 sont des vues en coupe illustrant les étapes successives effectuées par le personnel soignant lors de l'utilisation du capuchon de transfert illustré sur la figure 1 ;
  • la figure 7 est une vue en perspective de la figure 5 ;
  • la figure 8 est une vue en coupe illustrant l'utilisation par le personnel soignant du capuchon de transfert de la figure 2 ;
  • les figures 9 à 11 sont des vues en coupe illustrant les étapes successives effectuées par le personnel soignant lors de l'utilisation du capuchon de transfert illustré sur la figure 3 ;
  • les figures 12 et 13 illustrent différentes variantes de moyens de verrouillage ; et
  • les figures 14 et 15 sont des vues en coupe illustrant le procédé d'assemblage du capuchon de transfert de la figure 1 ; et
  • la figure 16 est une vue en coupe illustrant le procédé d'assemblage du capuchon de transfert de la figure 3.
Other objects, features and advantages of the present invention will become apparent from the following description of particular embodiments, with reference to the accompanying figures, in which:
  • the figure 1 is a sectional view of a first variant of a first embodiment of transfer cap according to the invention;
  • the figure 2 is a sectional view of a second variant of the first embodiment of the transfer cap according to the invention;
  • the figure 3 is a sectional view of a second embodiment of transfer cap according to the invention;
  • the Figures 4 to 6 are sectional views illustrating the successive steps performed by the caregiver when using the transfer cap shown on the figure 1 ;
  • the figure 7 is a perspective view of the figure 5 ;
  • the figure 8 is a sectional view illustrating the use by the caregiver of the transfer cap of the figure 2 ;
  • the Figures 9 to 11 are sectional views illustrating the successive steps performed by the caregiver when using the transfer cap shown on the figure 3 ;
  • the Figures 12 and 13 illustrate different variants of locking means; and
  • the Figures 14 and 15 are sectional views illustrating the method of assembling the transfer cap of the figure 1 ; and
  • the figure 16 is a sectional view illustrating the method of assembling the transfer cap of the figure 3 .

Trois capuchons de transfert différents sont représentés sur les figures 1 à 3. Les figures 1 et 2 concernent un premier mode de réalisation de l'invention tandis que la figure 3 concerne un deuxième mode de réalisation de l'invention.Three different transfer caps are shown on the Figures 1 to 3 . The Figures 1 and 2 relate to a first embodiment of the invention while the figure 3 relates to a second embodiment of the invention.

Le premier mode de réalisation comporte deux variantes illustrées respectivement sur les figures 1 et 2. La différence entre la variante de la figure 1 et la variante de la figure 2 tient au type de poche de soluté qu'on peut connecter sur le capuchon de transfert. Le capuchon de transfert 100 de la figure 1 est adapté pour être connecté à une poche de soluté perforable, tandis que le capuchon de transfert de la figure 2 est adapté pour être connecté à une poche de soluté à cône luer.The first embodiment has two variants illustrated respectively on the Figures 1 and 2 . The difference between the variant of the figure 1 and the variant of the figure 2 is related to the type of solute bag that can be connected to the transfer cap. The transfer cap 100 of the figure 1 is adapted to be connected to a pierceable solute pocket, while the transfer cap of the figure 2 is suitable for connection to a luer cone solute bag.

Dans chacun des modes de réalisation de l'invention représentés sur les figures 1 à 3, le capuchon de transfert 100 comprend un premier tronçon tubulaire de connexion 1, comportant des premiers moyens de réception 1 a pour la connexion à un flacon perforable. Le capuchon de transfert 100 comprend en outre un second tronçon tubulaire de connexion 2, comportant des seconds moyens de réception 2a pour la connexion à une poche de soluté.In each of the embodiments of the invention shown in Figures 1 to 3 , the transfer cap 100 comprises a first tubular connection section 1, comprising first receiving means 1a for connection to a perforable bottle. The transfer cap 100 further comprises a second tubular connection section 2, comprising second receiving means 2a for connection to a solute bag.

Le capuchon de transfert 100 comporte en outre une aiguille 3 creuse de passage de fluide à premier tronçon d'extrémité d'aiguille 3a et à second tronçon d'extrémité d'aiguille 3b pour la connexion au flacon d'une part et à la poche de soluté d'autre part.The transfer cap 100 further comprises a hollow needle 3 for fluid passage with a first needle end portion 3a and a second needle end portion 3b for connection to the bottle on the one hand and the bag of solute on the other hand.

Des moyens d'étanchéité 5 obturent de façon étanche l'un des premier et second tronçons d'extrémité 3a ou 3b d'aiguille avant connexion du flacon à la poche de soluté.Sealing means 5 sealingly seal one of the first and second needle end sections 3a or 3b before connecting the bottle to the solute bag.

Le premier tronçon tubulaire de connexion 1 est porté par un premier corps tubulaire 10 tandis que le second tronçon tubulaire de connexion 2 est porté par un second corps tubulaire 20.The first tubular connection section 1 is carried by a first tubular body 10 while the second tubular connection section 2 is carried by a second tubular body 20.

Dans le premier mode de réalisation illustré sur les figures 1 et 2, l'aiguille 3 est portée par une paroi transversale 4 du second corps tubulaire 20. Dans le deuxième mode de réalisation de l'invention illustré sur la figure 3, l'aiguille 3 est portée par une paroi transversale 4 du premier corps tubulaire 10.In the first embodiment illustrated on the Figures 1 and 2 , the needle 3 is carried by a transverse wall 4 of the second tubular body 20. In the second embodiment of the invention illustrated in FIG. figure 3 , the needle 3 is carried by a transverse wall 4 of the first tubular body 10.

L'aiguille 3 peut être fixée dans la paroi transversale 4 par vissage, collage, surmoulage, clipsage ou par tout autre moyen de fixation convenable permettant d'assurer une bonne étanchéité.The needle 3 can be fixed in the transverse wall 4 by screwing, gluing, overmolding, clipping or by any other suitable fastening means to ensure a good seal.

Les premier et second corps tubulaires 10 et 20 s'étendent selon une direction longitudinale I-I et sont montés coaxialement et à coulissement longitudinal l'un par rapport à l'autre. Les premier et second corps tubulaires 10 et 20 sont ainsi déplaçables entre une position de repos illustrée sur les figures 1, 2 et 3, et une position de transfert illustrée sur les figures 6 et 11. En position de transfert, les tronçons tubulaires de connexion 1 et 2 sont rapprochés l'un de l'autre. En position de transfert, les premier et second corps tubulaires 10 et 20 ont un recouvrement mutuel supérieur au recouvrement mutuel qu'ils présentent lorsqu'ils sont en position de repos.The first and second tubular bodies 10 and 20 extend in a longitudinal direction II and are mounted coaxially and longitudinally sliding relative to each other. The first and second tubular bodies 10 and 20 are thus movable between a rest position illustrated on the Figures 1, 2 and 3 , and an illustrated transfer position on the figures 6 and 11 . In the transfer position, the tubular connecting sections 1 and 2 are brought closer to each other. In the transfer position, the first and second tubular bodies 10 and 20 have a mutual overlap greater than the mutual overlap they have when in the rest position.

On voit bien sur les figures 1 à 3 que les moyens d'étanchéité 5 sont solidaires de la paroi transversale 6 portée par l'un des corps tubulaires 10 ou 20, et obturent de façon étanche au moins un tronçon d'extrémité d'aiguille 3a ou 3b en position de repos (figures 1 à 3).We can clearly see Figures 1 to 3 that the sealing means 5 are integral with the transverse wall 6 carried by one of the tubular bodies 10 or 20, and sealingly seal at least one needle end portion 3a or 3b in the rest position ( Figures 1 to 3 ).

Les moyens d'étanchéité 5 sont perforés par l'aiguille 3 lors du déplacement des corps tubulaires 10 et 20 vers la position de transfert (figures 6 et 11).The sealing means 5 are perforated by the needle 3 during the displacement of the tubular bodies 10 and 20 towards the transfer position ( figures 6 and 11 ).

Dans le premier mode de réalisation, la paroi transversale 4 portant l'aiguille 3 appartient au second corps tubulaire 20, tandis que la paroi transversale 6 portant les moyens d'étanchéité 5 appartient au premier corps tubulaire 10.In the first embodiment, the transverse wall 4 carrying the needle 3 belongs to the second tubular body 20, while the transverse wall 6 carrying the sealing means 5 belongs to the first tubular body 10.

Dans le second mode de réalisation de l'invention, la paroi transversale 4 portant l'aiguille 3 appartient au premier corps tubulaire 10 tandis que la paroi transversale 6 portant les moyens d'étanchéité 5 appartient au second corps tubulaire 20.In the second embodiment of the invention, the transverse wall 4 carrying the needle 3 belongs to the first tubular body 10 while the transverse wall 6 carrying the sealing means 5 belongs to the second tubular body 20.

Dans le premier mode de réalisation, en position de repos, le second tronçon d'extrémité d'aiguille 3b dépasse dans le second corps tubulaire 20, de sorte que la seule connexion de la poche de soluté au second tronçon tubulaire de connexion suffit pour mettre en communication le contenu de la poche de soluté avec le passage creux de l'aiguille 3. Dans le second mode de réalisation, en position de repos, le premier tronçon d'extrémité d'aiguille 3a dépasse dans le premier corps tubulaire 10, de sorte que la seule connexion du flacon au premier tronçon tubulaire de connexion 1 suffit pour mettre en communication le contenu du flacon avec le passage creux de l'aiguille 3.In the first embodiment, in the rest position, the second needle end portion 3b protrudes into the second tubular body 20, so that the sole connection of the solute bag to the second tubular connecting portion is sufficient to in communication the contents of the solute bag with the hollow passage of the needle 3. In the second embodiment, in the rest position, the first needle end section 3a protrudes into the first tubular body 10, so that the single connection of the vial to the first connecting tubular section 1 is sufficient to bring the contents of the vial into communication with the hollow passage of the needle 3.

Pour des facilités de fabrication et pour garantir une bonne étanchéité, l'aiguille 3 est surmoulée dans la paroi transversale 4.For ease of manufacture and to ensure a good seal, the needle 3 is overmolded in the transverse wall 4.

Les moyens d'étanchéité 5 sont quant à eux solidaires de la paroi transversale 6 et comprennent un manchon borgne 5a engagé de façon étanche sur le premier tronçon d'extrémité d'aiguille 3a (figures 1 et 2) ou sur le second tronçon d'extrémité d'aiguille 3b (figure 3) en position de repos.The sealing means 5 are integral with the transverse wall 6 and comprise a blind sleeve 5a sealingly engaged on the first needle end portion 3a ( Figures 1 and 2 ) or on the second needle end portion 3b ( figure 3 ) in the rest position.

Les moyens d'étanchéité 5, la paroi transversale 6 portant les moyens d'étanchéité 5, et le corps tubulaire 10 ou 20 à paroi transversale 6 portant les moyens d'étanchéité 5, sont formés d'une seule pièce, comme on le voit plus particulièrement sur les figures 1 à 3 grâce aux hachures de ces vues en coupe.The sealing means 5, the transverse wall 6 carrying the sealing means 5, and the tubular body 10 or 20 with a transverse wall 6 carrying the sealing means 5, are formed in one piece, as can be seen especially on Figures 1 to 3 thanks to the hatching of these sectional views.

Le caractère monobloc des moyens d'étanchéité 5, de la paroi transversale 6 et du corps tubulaire 10 ou 20 (selon le mode de réalisation de l'invention) permet une fabrication par moulage, par injection plastique par exemple. Les moyens d'étanchéité 5 présentent ainsi une étanchéité parfaite avec la paroi transversale 6 et sont positionnés de façon très précise coaxialement le long de l'axe longitudinal I-I du corps tubulaire 10 ou 20.The one-piece character of the sealing means 5, the transverse wall 6 and the tubular body 10 or 20 (according to the embodiment of the invention) allows a manufacturing by molding, plastic injection for example. The sealing means 5 thus have a perfect seal with the transverse wall 6 and are positioned very precisely coaxially along the longitudinal axis I-I of the tubular body 10 or 20.

En alternative, les moyens d'étanchéité 5 peuvent être rapportés et fixés sur la paroi transversale 6. Leur montage est alors effectué avant l'emboîtement des premier et second corps tubulaires 10 et 20 et est sans risque pour un opérateur.Alternatively, the sealing means 5 can be attached and fixed on the transverse wall 6. Their assembly is then carried out before the interlocking first and second tubular bodies 10 and 20 and is safe for an operator.

L'aiguille 3 est aussi positionnée de façon précise coaxialement à l'axe I-I du corps tubulaire 10 ou 20. En conséquence, l'engagement de l'un des premier et second tronçons d'extrémité d'aiguille 3a et 3b se fait facilement et automatiquement en assemblant de façon coaxiale les premier et second corps tubulaires 10 et 20. Le montage est ainsi simple et sans risque d'erreur.The needle 3 is also positioned precisely coaxially with the axis II of the tubular body 10 or 20. As a result, the engagement of one of the first and second needle end portions 3a and 3b is easily accomplished. and automatically by assembling coaxially the first and second tubular bodies 10 and 20. The assembly is thus simple and without risk of error.

Dans le premier mode de réalisation de l'invention, le second corps tubulaire 20 à paroi transversale 4 portant l'aiguille 3 est réalisé en une matière plastique dure, en polystyrène de préférence, tandis que le premier corps tubulaire 10 à paroi transversale 6 portant les moyens d'étanchéité 5 est réalisé en une matière plastique plus molle, perforable par l'aiguille 3, en polypropylène ou en polyéthylène de préférence.In the first embodiment of the invention, the second tubular body 20 with transverse wall 4 carrying the needle 3 is made of a hard plastic material, preferably of polystyrene, while the first tubular body 10 having a transverse wall 6 carrying the sealing means 5 is made of a softer plastic material, pierceable by the needle 3, polypropylene or preferably polyethylene.

Dans le second mode de réalisation de l'invention, le premier corps tubulaire 10 est réalisé en une matière plastique dure, en polystyrène de préférence, tandis que le second corps tubulaire 20 est réalisé en une matière plastique plus molle, perforable par l'aiguille 3, en polypropylène ou en polyéthylène de préférence.In the second embodiment of the invention, the first tubular body 10 is made of a hard plastic material, preferably polystyrene, while the second tubular body 20 is made of a softer plastic material, pierceable by the needle 3, polypropylene or polyethylene preferably.

Dans l'un et l'autre des modes de réalisation de l'invention, le capuchon de transfert 100 comprend des moyens de maintien 7 pour garder les corps tubulaires 10 et 20 emboîtés l'un dans l'autre.In either embodiment of the invention, the transfer cap 100 includes holding means 7 for keeping the tubular bodies 10 and 20 nested within each other.

Le capuchon de transfert des premier et second modes de réalisation comprend en outre des moyens de verrouillage 8 déverrouillables pour sélectivement maintenir les corps tubulaires 10 et 20 en position de repos (figure 1 à 3) ou autoriser le déplacement des corps tubulaires 10 et 20 vers la position de transfert (figures 6 et 11).The transfer cap of the first and second embodiments further comprises releasable locking means 8 for selectively holding the tubular bodies 10 and 20 in the rest position ( figure 1 to 3 ) or allow the displacement of the tubular bodies 10 and 20 towards the transfer position ( figures 6 and 11 ).

On voit plus particulièrement sur les figures 1 à 3 que les moyens de maintien 7 comprennent deux ergots extérieurs radiaux 7a et 7b portés par le second corps tubulaire 20. Les ergots extérieurs radiaux 7a et 7b sont aptes à coulisser axialement selon la direction longitudinale I-I dans respectivement des lumières longitudinale 70a et 70b. Les lumières longitudinales 70a et 70b sont prévues dans la paroi tubulaire du premier corps tubulaire 10 et sont fermées à leurs deux extrémités 701 a, 702a, 701 b et 702b.We see more particularly the Figures 1 to 3 that the holding means 7 comprise two radial outer lugs 7a and 7b carried by the second tubular body 20. The radial outer lugs 7a and 7b are able to slide axially in the longitudinal direction II in respectively longitudinal slots 70a and 70b. The longitudinal slots 70a and 70b are provided in the tubular wall of the first tubular body 10 and are closed at their two ends 701a, 702a, 701b and 702b.

Les extrémités 701 a et 701 b des lumières longitudinales 70a et 70b étant fermées, celles-ci empêchent, avec les ergots extérieurs radiaux 7a et 7b, la séparation des corps tubulaires 10 et 20 selon des mouvements de translation axiale l'un à l'écart de l'autre illustrés par les flèches 9a et 9b (figures 1 à 3).The ends 701a and 701b of the longitudinal slots 70a and 70b being closed, these prevent, with the radial outer lugs 7a and 7b, the separation of the tubular bodies 10 and 20 in axial translation movements one to the other. away from each other illustrated by arrows 9a and 9b ( Figures 1 to 3 ).

On voit plus particulièrement sur les figures 1 à 3 que les moyens de verrouillage 8 déverrouillables comprennent, dans les lumières longitudinales 70a et 70b, au voisinage des extrémités 701 a et 701 b, des premiers moyens de rétention 11 des ergots extérieurs radiaux 7a-7b. Les extrémités 701 a et 701 b des lumières longitudinales 70a et 70b se trouvent à l'opposé du premier tronçon tubulaire de connexion 1 du premier corps tubulaire 10.We see more particularly the Figures 1 to 3 that the unlocking locking means 8 comprise, in the longitudinal slots 70a and 70b, in the vicinity of the ends 701a and 701b, first retaining means 11 radial outer pins 7a-7b. The ends 701a and 701b of the longitudinal slots 70a and 70b lie opposite the first tubular connection section 1 of the first tubular body 10.

Dans le mode de réalisation illustré sur les figures 1 à 3, les premiers moyens de rétention 11 des ergots extérieurs radiaux 7a et 7b sont un encliquetage réversible assuré au moyen de barrettes transversales 11 a et 11 b.In the embodiment illustrated on the Figures 1 to 3 , the first retaining means 11 radial outer pins 7a and 7b are a reversible latching provided by means of transverse bars 11a and 11b.

L'invention n'est pas limitée à des premiers moyens de rétention 11 à barrettes transversales 11 a et 11 b. Elle peut comprendre d'autres formes de premiers moyens de rétention 11 telles qu'illustrées sur les figures 12 et 13 par exemple : sur la figure 12, l'extrémité 701 a de la lumière 70a comprend un tronçon transversal, de sorte que le déverrouillage nécessite un mouvement préalable volontaire de rotation axiale des corps tubulaires 10 et 20 l'un par rapport à l'autre ; sur la figure 13, les premiers moyens de rétention 11 sont un rétrécissement de la lumière longitudinale 70a, qui nécessite un effort axial supplémentaire.The invention is not limited to first retaining means 11 with transverse bars 11a and 11b. It may comprise other forms of first retention means 11 as illustrated on the Figures 12 and 13 for example: on the figure 12 the end 701a of the light 70a comprises a transverse section, so that the unlocking requires a voluntary forward movement of axial rotation of the tubular bodies 10 and 20 relative to each other; on the figure 13 , the first retention means 11 are a narrowing of the longitudinal lumen 70a, which requires an additional axial force.

Dans le cas des figures 12 et 13, les lumières 70a et 70b comprennent aussi, au voisinage des extrémités 702a et 702b, d'autres moyens de rétention 11' des ergots extérieurs radiaux 7a et 7b.In the case of Figures 12 and 13 , the lights 70a and 70b also comprise, in the vicinity of the ends 702a and 702b, other retaining means 11 'radial outer lugs 7a and 7b.

On dispose ainsi de premiers moyens de rétention 11 pour sélectivement maintenir les corps tubulaires 10 et 20 en position de repos ou autoriser le déplacement des corps tubulaires 10 et 20 vers la position de transfert, et on dispose d'autres moyens de rétention 11' pour maintenir les corps tubulaires 10 et 20 en position de transfert.There are thus first retention means 11 for selectively maintaining the tubular bodies 10 and 20 in the rest position or allowing the displacement of the tubular bodies 10 and 20 to the transfer position, and other retention means 11 'are available for maintain the tubular bodies 10 and 20 in the transfer position.

Sur les figures 1 à 3, on voit que le premier tronçon tubulaire de connexion 1 comporte des seconds moyens de rétention 12 aptes à recevoir et retenir le flacon 16. Les seconds moyens de rétention 12 comportent une ou plusieurs tiges axiales élastiques 12a à extrémité libre 12b et à ergot radial rentrant 12c. Dans la réalisation illustrée, les seconds moyens de rétention 12 comportent trois tiges axiales élastiques 12a pour recevoir et retenir le flacon de façon fiable par encliquetage.On the Figures 1 to 3 , it can be seen that the first tubular connection section 1 comprises second retention means 12 able to receive and hold the vial 16. The second retention means 12 comprise one or more elastic axial rods 12a with a free end 12b and a radial pin that retracts 12c. In the illustrated embodiment, the second retention means 12 comprise three elastic axial rods 12a for receiving and retaining the bottle reliably snap.

Le procédé de montage des capuchons de transfert selon l'invention est simple et sans risque d'erreur. Le premier corps tubulaire 10 et le second corps tubulaire 20 sont fabriqués indépendamment. Les corps tubulaires 10 et 20 sont ensuite positionnés coaxialement avec les premier et second tronçons tubulaires de connexion 1 et 2 orientés l'un à l'écart de l'autre (figure 14). Les premiers et seconds corps tubulaires 10 et 20 sont alors rapprochés l'un de l'autre selon un mouvement illustré par les flèches 13a et 13b.The mounting method of the transfer caps according to the invention is simple and without risk of error. The first tubular body 10 and the second tubular body 20 are manufactured independently. The tubular bodies 10 and 20 are then positioned coaxially with the first and second connecting tubular sections 1 and 2 oriented one away from the other ( figure 14 ). The first and second tubular bodies 10 and 20 are then brought closer to each other in a movement illustrated by the arrows 13a and 13b.

Dans le premier mode de réalisation, le tronçon d'extrémité 14 du premier corps tubulaire 10 se déforme légèrement en s'évasant pour recevoir l'extrémité 15 du second corps tubulaire 20 et les ergots radiaux 7a et 7b (figure 15). L'extrémité 15 est l'extrémité du second corps tubulaire 20 opposée au second tronçon tubulaire de connexion 2, tandis que l'extrémité 14 est l'extrémité du premier corps tubulaire 10 opposée au premier tronçon tubulaire de connexion 1.In the first embodiment, the end portion 14 of the first tubular body 10 is slightly deformed by flaring to receive the end 15 of the second tubular body 20 and the radial lugs 7a and 7b ( figure 15 ). The end 15 is the end of the second tubular body 20 opposite to the second tubular connecting portion 2, while the end 14 is the end of the first tubular body 10 opposite to the first tubular connecting portion 1.

Pour faciliter la déformation de l'extrémité 14, le second corps tubulaire 20 est réalisé en une matière plastique dure, en polystyrène de préférence, tandis que le premier corps tubulaire 10 est réalisé en une matière plastique plus molle, en polypropylène ou en polyéthylène de préférence.To facilitate the deformation of the end 14, the second tubular body 20 is made of a hard plastic material, preferably polystyrene, while the first tubular body 10 is made of a softer plastic material, polypropylene or polyethylene. preference.

Comme illustré sur la figure 16, dans le second mode de réalisation de l'invention, c'est l'extrémité 15 du corps tubulaire 20 qui se déforme légèrement et élastiquement pour autoriser l'assemblage des corps tubulaires 10 et 20. Pour ce faire, le corps tubulaire 10 est réalisé en une matière plastique dure, en polystyrène de préférence, tandis que le corps tubulaire 20 est réalisé en une matière plastique plus molle, en polypropylène ou en polyéthylène de préférence.As illustrated on the figure 16 in the second embodiment of the invention, it is the end 15 of the tubular body 20 that deforms slightly and elastically to allow the assembly of the tubular bodies 10 and 20. To do this, the tubular body 10 is made of a hard plastic material, preferably polystyrene, while the tubular body 20 is made of a softer plastic material, polypropylene or preferably polyethylene.

Après les étapes initiales d'insertion illustrées sur les figures 15 et 16, la personne chargée de l'assemblage poursuit le mouvement de rapprochement relatif des corps tubulaires 10 et 20 illustré par les flèches 13a et 13b, jusqu'à amener les ergots radiaux 7a et 7b dans les moyens de verrouillage 8 prévus aux extrémités 701 a et 701 b des lumières 70a et 70b. L'assemblage du capuchon de transfert est alors terminé et les corps tubulaires 10 et 20 sont disposés en position de repos avec l'un premier ou second tronçons d'extrémité 3a ou 3b de l'aiguille 3 engagé de façon étanche dans les moyens d'étanchéité 5.After the initial stages of insertion illustrated on the Figures 15 and 16 , the person in charge of the assembly continues the relative movement of the tubular bodies 10 and 20 illustrated by the arrows 13a and 13b, until bringing the radial lugs 7a and 7b into the locking means 8 provided at the ends 701a and 701 b lights 70a and 70b. The assembly of the transfer cap is then completed and the tubular bodies 10 and 20 are arranged in the rest position with the first or second end portions 3a or 3b of the needle 3 sealingly engaged in the sealing means. sealing 5.

On comprend que l'engagement de l'un des tronçons d'extrémité 3a ou 3b dans les moyens d'étanchéité 5 se fait automatiquement par l'assemblage coaxial des corps tubulaires 10 et 20 sans que le personnel de fabrication n'ait à effectuer d'actions spécifiques autres que l'assemblage des corps tubulaires 10 et 20 par un simple mouvement de translation relative.It is understood that the engagement of one of the end sections 3a or 3b in the sealing means 5 is done automatically by the coaxial assembly of the tubular bodies 10 and 20 without the manufacturing personnel having to perform specific actions other than the assembly of the tubular bodies 10 and 20 by a simple relative translational movement.

Aucune dextérité particulière n'est donc requise pour le personnel de fabrication, l'engagement de l'un des premier ou second tronçons d'extrémité 3a ou 3b de l'aiguille 3 dans le manchon borgne 5a se faisant de façon sûre, fiable et transparente pour le personnel de fabrication. De même, ce simple mouvement de translation relative peut facilement faire l'objet d'un procédé automatisé de montage.No particular dexterity is therefore required for the manufacturing staff, the engagement of one of the first or second end portions 3a or 3b of the needle 3 in the blind sleeve 5a is done in a safe, reliable and transparent for manufacturing personnel. Likewise, this simple relative translation movement can easily be the subject of an automated assembly process.

Considérons désormais les figures 4 à 6 qui illustrent l'utilisation du capuchon de transfert de la figure 1.Now consider Figures 4 to 6 which illustrate the use of the transfer cap of the figure 1 .

Sur la figure 4, l'utilisateur saisit un capuchon de transfert 100 en position de repos et connecte un flacon 16 à opercule perforable 16a au premier tronçon tubulaire de connexion 1. Cette connexion peut être effectuée indifféremment en engageant l'extrémité à opercule perforable 16a du flacon 16 dans le premier tronçon tubulaire de connexion 1 alors que l'utilisateur tient le capuchon de transfert 100 par le premier corps tubulaire 10, ou en rapportant le capuchon de transfert 100 sur l'extrémité à opercule perforable 16a du flacon 16, l'utilisateur tenant le capuchon de transfert 100 par le seul premier corps tubulaire 10. Dans cet état, la poche de soluté 17 est à l'écart du capuchon de transfert 100.On the figure 4 , the user grasps a transfer cap 100 in the rest position and connects a flask 16 with a pierceable lid 16a to the first tubular connection section 1. This connection can be carried out either by engaging the pierceable lid end 16a of the bottle 16 in the first tubular connection section 1 while the user holds the transfer cap 100 by the first tubular body 10, or by bringing the transfer cap 100 onto the pierceable lid end 16a of the bottle 16, the user holding the transfer cap 100 by the single first tubular body 10. In this state, the solute bag 17 is away from the transfer cap 100.

Sur les figures 5 et 7, l'utilisateur rapporte ensuite une poche de soluté perforable 17 à embout perforable 17a, en engageant l'embout perforable 17a dans le second tronçon tubulaire de connexion 2 selon un mouvement illustré par la flèche 18, le capuchon de transfert 100 restant en position de repos. Le contenu de la poche de soluté perforable 17 est alors mis en communication avec le passage creux de l'aiguille 3 mais ne peut pas s'écouler, le premier tronçon d'extrémité d'aiguille 3a étant engagé dans le manchon borgne 5a de façon étanche.On the figures 5 and 7 , the user then reports a pierceable solute bag 17 with a pierceable tip 17a, by engaging the pierceable tip 17a in the second tubular connection section 2 in a movement illustrated by the arrow 18, the transfer cap 100 remaining in the position of rest. The contents of the pierceable solute bag 17 are then placed in communication with the hollow passage of the needle 3 but can not flow, the first needle end portion 3a being engaged in the blind sleeve 5a so that waterproof.

On choisit des moyens de verrouillage 8 aptes à empêcher tout coulissement des corps tubulaires 10 et 20 l'un par rapport à l'autre avant que l'embout perforable 17a ne soit perforé par l'aiguille 3.Locking means 8 are chosen which are able to prevent the tubular bodies 10 from sliding relative to one another before the pierceable tip 17a is perforated by the needle 3.

Lorsque l'utilisateur souhaite préparer le médicament, il rapproche le flacon 16 et la poche de soluté 17 en appliquant une force tendant à déplacer les premiers et seconds corps tubulaires 10 et 20 depuis leur position de repos jusque dans leur position de transfert.When the user wishes to prepare the drug, he brings the bottle 16 and the solute bag 17 closer together by applying a force tending to move the first and second tubular bodies 10 and 20 from their rest position to their transfer position.

Lors de l'application de cette force, les ergots extérieurs radiaux 7a et 7b provoquent la déformation radiale des barrettes transversales 11 a et 11 b des premiers moyens de rétention 11. Les barrettes transversales 11 a et 11 b sont en effet en une matière plastique molle et sont donc déformables.During the application of this force, the radial outer lugs 7a and 7b cause the radial deformation of the transverse bars 11a and 11b of the first retention means 11. The transverse bars 11a and 11b are indeed made of a plastic material soft and are therefore deformable.

Après avoir déformé radialement les barrettes transversales 11 a et 1 1 b par les faces d'attaque respectives obliques 19a et 19b, les premier et second corps tubulaires 10 et 20 peuvent se déplacer librement pour venir en position de transfert.After radially deforming the transverse bars 11a and 11b by the oblique respective leading faces 19a and 19b, the first and second tubular bodies 10 and 20 can move freely to come into the transfer position.

Lors de ce déplacement, le premier tronçon d'extrémité 3a de l'aiguille 3 vient perforer la paroi de fond 50a du manchon borgne 5a ainsi que l'opercule perforable 16a du flacon 16. On se trouve alors dans la position illustrée sur la figure 6, qui est la position de transfert.During this movement, the first end portion 3a of the needle 3 perforates the bottom wall 50a of the blind sleeve 5a and the perforable lid 16a of the bottle 16. It is then in the position illustrated on the figure 6 , which is the transfer position.

La figure 8 est une vue en coupe illustrant l'utilisation du capuchon de transfert de la figure 2.The figure 8 is a sectional view illustrating the use of the transfer cap of the figure 2 .

L'utilisation de ce capuchon de transfert est semblable à celle du capuchon de transfert de la figure 1, et ne diffère de celle-ci que par le mode de connexion avec la poche de soluté 170 qui est une poche de soluté à embout 170a à cône luer.The use of this transfer cap is similar to that of the transfer cap of the figure 1 and differs therefrom only in connection with the solute bag 170 which is a luer cone solute bag 170a.

Pour la connexion de la poche 170, l'utilisateur visse l'embout 170a à cône luer dans le second tronçon tubulaire de connexion 2 du second corps tubulaire 20.For the connection of the pocket 170, the user screws the luer tip 170a into the second connecting tubular section 2 of the second tubular body 20.

Dans chacune des variantes du premier mode de réalisation illustrées sur les figures 1 et 2, le premier tronçon tubulaire de connexion 1 a un diamètre intérieur d1 plus important que le diamètre intérieur d2 du second tronçon tubulaire de connexion 2. Les embouts 17a et 170a des poches de soluté 17 et 170 permettent l'utilisation d'un diamètre d2 suffisamment faible pour empêcher la pénétration d'un doigt d'un utilisateur dans le second tronçon tubulaire de connexion 2. Il n'y a donc aucun risque à laisser le second tronçon d'extrémité d'aiguille 3b non protégé.In each of the variants of the first embodiment illustrated on the Figures 1 and 2 , the first tubular connection section 1 has an internal diameter d1 greater than the internal diameter d2 of the second connecting tubular section 2. The tips 17a and 170a of the solute bags 17 and 170 allow the use of a diameter d2 sufficiently weak to prevent the penetration of a finger of a user in the second connecting tubular section 2. There is therefore no risk to leave the second unprotected needle end portion 3b.

En revanche, le diamètre d1 doit permettre la connexion du flacon perforable 16, et celui-ci est par conséquent généralement suffisamment grand pour qu'un utilisateur puisse engager accidentellement un doigt dans le premier tronçon tubulaire de connexion 1.However, the diameter d1 must allow the connection of the perforable bottle 16, and it is therefore generally large enough for a user to accidentally engage a finger in the first tubular connecting portion 1.

Cependant, le manchon 5a permet d'envelopper le second tronçon d'extrémité d'aiguille 3b de façon qu'il n'y ait aucun risque pour un utilisateur de se piquer, même si celui-ci engage par inadvertance son doigt dans le premier tronçon tubulaire de connexion 1 lorsque le capuchon de transfert et en position de repos.However, the sleeve 5a is used to wrap the second needle end portion 3b so that there is no risk for a user to prick, even if it inadvertently engages his finger in the first connecting tubular section 1 when the transfer cap and in the rest position.

Enfin, il n'y a pas lieu de se poser la question de protection du second tronçon d'extrémité d'aiguille 3b en position de transfert, celui-ci étant alors engagé dans le flacon 16, lequel flacon 16 étant maintenu connecté dans le premier tronçon tubulaire de connexion 1 par les seconds moyens de rétention 12.Finally, there is no need to ask the question of protection of the second needle end portion 3b in the transfer position, which is then engaged in the bottle 16, which bottle 16 is kept connected in the first tubular connecting section 1 by the second retention means 12.

Considérons désormais les figures 9 à 11 qui illustrent l'utilisation du capuchon de transfert illustré sur la figure 3.Now consider Figures 9 to 11 which illustrate the use of the transfer cap shown on the figure 3 .

Lors de cette utilisation, l'utilisateur connecte le flacon 16 au premier tronçon tubulaire de connexion 1 (figure 9). Lors de cette connexion, le second tronçon d'extrémité d'aiguille 3b, dépassant dans le corps tubulaire 10, perce l'opercule perforable 16a. Le contenu du flacon 16 est alors mis en communication avec le passage creux de l'aiguille 3.During this use, the user connects the bottle 16 to the first tubular connecting section 1 ( figure 9 ). During this connection, the second needle end portion 3b protruding into the tubular body 10 pierces the pierceable lid 16a. The contents of the bottle 16 are then placed in communication with the hollow passage of the needle 3.

L'utilisateur rapporte alors la poche de soluté 17 à embout perforable 17a en engageant l'embout perforable 17a dans le second tronçon tubulaire de connexion 2 (figure 10) selon un mouvement illustré par la flèche 18.The user then reports the solute bag 17 with pierceable tip 17a by engaging the pierceable tip 17a in the second tubular connection section 2 (FIG. figure 10 ) in a movement illustrated by the arrow 18.

L'utilisateur applique alors une force tendant à déverrouiller les moyens de verrouillage 8 et à déplacer les premier et second corps tubulaire 10 et 20 en position de transfert, ce qui a pour effet de provoquer le percement de la paroi de fond 50a du manchon borgne 5a et de l'embout perforable 17a.The user then applies a force tending to unlock the locking means 8 and move the first and second tubular body 10 and 20 in the transfer position, which has the effect of causing the piercing of the bottom wall 50a of the blind sleeve 5a and the pierceable tip 17a.

On se trouve alors en position de transfert, comme illustré sur la figure 11 : les cavités intérieures de la poche 17 et du flacon 16 sont mises en communication pour le passage des fluides et la préparation de la substance médicamenteuse.We are then in the transfer position, as shown on the figure 11 the inner cavities of the bag 17 and the bottle 16 are placed in communication for the passage of the fluids and the preparation of the drug substance.

On observe qu'au cours de l'utilisation de chacun des modes de réalisation de l'invention, le personnel soignant choisit le moment où il met en communication les cavités intérieures des poches 17 ou 170 et du flacon 16 par un geste simple, sans risque d'erreur, le déplacement des corps tubulaires 10 et 20, en position de transfert ne pouvant être provoqué que par une action volontaire et délibérée de la part de l'utilisateur.It is observed that during the use of each of the embodiments of the invention, the nursing staff selects the moment when it puts in communication the inner cavities of the pockets 17 or 170 and the vial 16 by a simple gesture, without risk of error, the displacement of the tubular bodies 10 and 20, in the transfer position can be caused only by a deliberate and deliberate action on the part of the user.

On observe en outre que dans le cas du premier mode de réalisation de l'invention, une éventuelle projection du contenu du flacon 16 est nécessairement confinée dans la poche de soluté 17 ou 170, car l'opercule 16a du flacon 16 ne peut être perforé par l'aiguille 3 que et uniquement si la poche de soluté 17 ou 170 est préalablement connectée à l'extrémité tubulaire de connexion 2.It is further observed that in the case of the first embodiment of the invention, a possible projection of the contents of the bottle 16 is necessarily confined in the solute bag 17 or 170, because the lid 16a of the bottle 16 can not be perforated by the needle 3 that and only if the solute bag 17 or 170 is previously connected to the tubular connection end 2.

Il en est de même lors de l'utilisation du second mode de réalisation de l'invention. Le phénomène de projection ne se produit pas lors du percement de l'opercule perforable 16a du flacon 16, le second tronçon d'extrémité d'aiguille 3b étant engagé de façon étanche dans le manchon 5a des moyens d'étanchéité 5. Le phénomène de projection ne peut se produire que lorsque l'aiguille 3 a pénétré dans l'embout perforable 17a selon son second tronçon d'extrémité 3b.It is the same when using the second embodiment of the invention. The projection phenomenon does not occur during the piercing of the perforable seal 16a of the vial 16, the second end of the needle end 3b being sealingly engaged in the sleeve 5a of the sealing means 5. The phenomenon of projection can occur only when the needle 3 has penetrated into the pierceable tip 17a according to its second end portion 3b.

On observe également que même si l'utilisateur est distrait et intervertit l'ordre de connexion des poches de soluté 17 ou 170 et du flacon 16, il n'y a aucun risque de projection, et ce dans l'un quelconque des modes de réalisation de capuchon de transfert selon l'invention.It is also observed that even if the user is distracted and reverses the order of connection of the solute bags 17 or 170 and the bottle 16, there is no risk of projection, and this in any of the modes of embodiment of transfer cap according to the invention.

Dans l'un et l'autre des modes de réalisation de l'invention, l'utilisateur ne peut en aucun cas être exposé directement au phénomène de projection, ce dernier étant nécessairement confiné dans la poche de soluté 17 ou 170.In either embodiment of the invention, the user can not in any case be directly exposed to the projection phenomenon, the latter necessarily being confined in the solute bag 17 or 170.

La présente invention n'est pas limitée aux modes de réalisation qui ont été explicitement décrits, mais elle en inclut les diverses variantes et généralisations contenues dans le domaine des revendications ci-après.The present invention is not limited to the embodiments which have been explicitly described, but it includes the various variants and generalizations thereof within the scope of the claims below.

Claims (10)

Capuchon de transfert (100) pour transférer vers une poche de soluté perforable (17) ou à cône luer (170) une substance, notamment médicamenteuse, contenue dans un flacon perforable (16), comprenant : - un premier tronçon tubulaire de connexion (1), comportant des premiers moyens de réception (1a) pour la connexion au flacon perforable (16), - un second tronçon tubulaire de connexion (2), comportant des seconds moyens de réception (2a) pour la connexion à la poche de soluté (17, 170), - une aiguille (3) creuse de passage de fluide à premier (3a) et second (3b) tronçons d'extrémité d'aiguille pour la connexion au flacon (16) d'une part et à la poche de soluté (17, 170) d'autre part, portée par une paroi transversale (4) d'un corps tubulaire (10 ; 20) longitudinal, - des moyens d'étanchéité (5), obturant de façon étanche l'un des premier (3a) et second (3b) tronçons d'extrémité d'aiguille avant connexion du flacon (16) à la poche de soluté (17, 170), dans lequel : - les premier (1) et second (2) tronçons tubulaires de connexion sont portés respectivement par des premier (10) et second (20) corps tubulaires distincts montés coaxialement et à coulissement longitudinal l'un par rapport à l'autre, et déplaçables entre une position de repos et une position de transfert dans laquelle les tronçons tubulaires de connexion (1, 2) sont rapprochés l'un de l'autre, - les moyens d'étanchéité (5) sont solidaires d'une paroi transversale (6) portée par l'un des corps tubulaires (10, 20), et obturent de façon étanche ledit au moins un tronçon d'extrémité d'aiguille (3a, 3b) en position de repos, - les moyens d'étanchéité (5) sont perforés par l'aiguille (3) lors du déplacement des corps tubulaires (10, 20) vers la position de transfert, caractérisé en ce que : - l'aiguille (3) est fixée dans la paroi transversale (4) de l'un des corps tubulaires (10, 20), - les moyens d'étanchéité sont solidaires de la paroi transversale (6) de l'autre des corps tubulaires (10, 20). Transfer cap (100) for transferring to a perforable solute bag (17) or luer cone (170) a substance, including a medicament, contained in a perforable bottle (16), comprising: a first tubular connecting section (1), comprising first receiving means (1a) for connection to the perforable bottle (16), a second tubular connecting section (2), comprising second receiving means (2a) for connection to the solute bag (17, 170), - a needle (3) hollow fluid passage with first (3a) and second (3b) needle end portions for connection to the bottle (16) on the one hand and the solute bag (17, 170 ) on the other hand, carried by a transverse wall (4) of a longitudinal tubular body (10; - Sealing means (5), sealingly sealing one of the first (3a) and second (3b) needle end sections before connection of the bottle (16) to the solute bag (17, 170). ) in which : the first (1) and second (2) tubular connection sections are carried respectively by first (10) and second (20) separate tubular bodies mounted coaxially and longitudinally sliding relative to one another, and movable between a rest position and a transfer position in which the tubular connection sections (1, 2) are brought closer to one another, the sealing means (5) are integral with a transverse wall (6) carried by one of the tubular bodies (10, 20), and seal said at least one needle end portion ( 3a, 3b) in the rest position, the sealing means (5) are perforated by the needle (3) during the displacement of the tubular bodies (10, 20) towards the transfer position, characterized in that the needle (3) is fixed in the transverse wall (4) of one of the tubular bodies (10, 20), - The sealing means are integral with the transverse wall (6) of the other tubular bodies (10, 20). Capuchon de transfert selon la revendication 1, caractérisé en ce que, en position de repos, l'un des tronçons d'extrémité d'aiguille (3a, 3b) dépasse dans l'un des corps tubulaires (10 ; 20), de sorte que la seule connexion du flacon (16) ou de la poche de soluté (17, 170) au tronçon tubulaire de connexion (1, 2) dudit corps tubulaire (10, 20) suffit pour mettre en communication le contenu du flacon (16) ou de la poche de soluté (17, 170) avec le passage creux de l'aiguille (3).Transfer cap according to claim 1, characterized in that, in the rest position, one of the needle end sections (3a, 3b) protrudes into one of the tubular bodies (10; 20) so that the single connection of the flask (16) or the solute bag (17, 170) to the tubular connecting section (1, 2) of said tubular body (10, 20) is sufficient to place in communication the contents of the vial (16) or solute bag (17, 170) with the hollow passage of the needle (3). Capuchon de transfert selon l'une des revendications 1 ou 2, caractérisé en ce que : - l'aiguille (3) est surmoulée dans la paroi transversale (4) de l'un des corps tubulaires (10, 20), - les moyens d'étanchéité (5), solidaires de la paroi transversale (6) de l'autre des corps tubulaires (10, 20), comprennent un manchon borgne (5a) engagé de façon étanche sur le tronçon d'extrémité d'aiguille (3a, 3b) correspondant en position de repos. Transfer cap according to one of claims 1 or 2, characterized in that: the needle (3) is overmolded in the transverse wall (4) of one of the tubular bodies (10, 20), the sealing means (5), integral with the transverse wall (6) of the other of the tubular bodies (10, 20), comprise a blind sleeve (5a) sealingly engaged on the end section of corresponding needle (3a, 3b) in the rest position. Capuchon de transfert selon l'une quelconque des revendications 1 à 3, caractérisé en ce que les moyens d'étanchéité (5), la paroi transversale (6) portant les moyens d'étanchéité (5), et le corps tubulaire (10, 20) à paroi transversale (6) portant les moyens d'étanchéité (5), sont formés d'une seule pièce.Transfer cap according to one of Claims 1 to 3, characterized in that the sealing means (5), the transverse wall (6) carrying the sealing means (5), and the tubular body (10, 20) with a transverse wall (6) carrying the sealing means (5) are formed in one piece. Capuchon de transfert selon l'une quelconque des revendications 1 à 4, caractérisé en ce que : - le corps tubulaire (10, 20) à paroi transversale (4) portant l'aiguille (3) est réalisé en une matière plastique dure, en polystyrène de préférence, - le corps tubulaire (10, 20) à paroi transversale (6) portant les moyens d'étanchéité (5) est réalisé en une matière plastique molle perforable par l'aiguille (3), en polypropylène ou en polyéthylène de préférence. Transfer cap according to one of Claims 1 to 4, characterized in that: the tubular body (10, 20) with a transverse wall (4) carrying the needle (3) is made of a hard plastic material, preferably of polystyrene, - The tubular body (10, 20) with a transverse wall (6) carrying the sealing means (5) is made of a soft plastic material perforable by the needle (3), polypropylene or preferably polyethylene. Capuchon de transfert selon l'une des revendications 1 à 5, caractérisé en ce qu'il comprend des moyens de maintien (7) pour garder les corps tubulaires (10, 20) emboîtés l'un dans l'autre.Transfer cap according to one of claims 1 to 5, characterized in that it comprises holding means (7) for keeping the tubular bodies (10, 20) nested one inside the other. Capuchon de transfert selon l'une des revendications 1 à 6, caractérisé en ce qu'il comprend des moyens de verrouillage (8) déverrouillables pour sélectivement maintenir les corps tubulaires (10, 20) en position de repos ou autoriser le déplacement des corps tubulaires (10, 20) vers la position de transfert.Transfer cap according to one of claims 1 to 6, characterized in that it comprises releasable locking means (8) for selectively holding the tubular bodies (10, 20) in the rest position or allowing the displacement of the tubular bodies (10, 20) to the transfer position. Capuchon de transfert selon l'une des revendications 6 ou 7, caractérisé en ce que les moyens de maintien (7) pour garder les corps tubulaires (10, 20) emboîtés l'un dans l'autre comprennent au moins un ergot extérieur radial (7a, 7b) porté par le second corps tubulaire (20), apte à coulisser axialement dans au moins une lumière longitudinale (70a, 70b) de la paroi tubulaire du premier corps tubulaire (10), ladite lumière longitudinale (70a, 70b) étant fermée à ses deux extrémités (701 a, 702a, 701 b, 702b).Transfer cap according to one of claims 6 or 7, characterized in that the holding means (7) for keeping the tubular bodies (10, 20) fitted one inside the other comprise at least one radial external lug ( 7a, 7b) carried by the second tubular body (20), able to slide axially in at least one longitudinal slot (70a, 70b) of the tubular wall of the first tubular body (10), said longitudinal slot (70a, 70b) being closed at both ends (701a, 702a, 701b, 702b). Capuchon de transfert selon la revendication 8, caractérisé en ce que les moyens de verrouillage (8) déverrouillables comprennent, dans la lumière longitudinale (70a, 70b), au voisinage de l'extrémité (701 a, 701 b) de lumière longitudinale (70a, 70b) opposée au premier tronçon tubulaire de connexion (1) du premier corps tubulaire (10), des premiers moyens de rétention (11) de l'ergot extérieur radial (7a, 7b), de préférence par encliquetage réversible.Transfer cap according to claim 8, characterized in that the unlockable locking means (8) comprise, in the longitudinal slot (70a, 70b), in the vicinity of the longitudinal light end (701a, 701b) (70a). , 70b) opposite to the first tubular connecting portion (1) of the first tubular body (10), first retaining means (11) of the radial outer lug (7a, 7b), preferably reversibly latching. Capuchon de transfert selon l'une des revendications 1 à 9, caractérisé en ce que le premier tronçon tubulaire de connexion (1) comporte des seconds moyens de rétention (12) aptes à recevoir et retenir le flacon (16), de préférence par encliquetage.Transfer cap according to one of claims 1 to 9, characterized in that the first tubular connecting section (1) comprises second retention means (12) adapted to receive and retain the bottle (16), preferably by snap-fastening .
EP20090153090 2008-02-18 2009-02-18 Transfer cap Withdrawn EP2090278A1 (en)

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FR2927533B1 (en) 2011-02-11

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