EP2046268B2 - Oral care composition - Google Patents
Oral care composition Download PDFInfo
- Publication number
- EP2046268B2 EP2046268B2 EP07788033.4A EP07788033A EP2046268B2 EP 2046268 B2 EP2046268 B2 EP 2046268B2 EP 07788033 A EP07788033 A EP 07788033A EP 2046268 B2 EP2046268 B2 EP 2046268B2
- Authority
- EP
- European Patent Office
- Prior art keywords
- oil
- oral care
- care composition
- wax
- pigment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 29
- 239000002775 capsule Substances 0.000 claims description 34
- 239000003921 oil Substances 0.000 claims description 31
- 235000019198 oils Nutrition 0.000 claims description 31
- 239000000049 pigment Substances 0.000 claims description 28
- 239000001993 wax Substances 0.000 claims description 24
- 239000011248 coating agent Substances 0.000 claims description 23
- 238000000576 coating method Methods 0.000 claims description 23
- 239000003605 opacifier Substances 0.000 claims description 12
- 235000019486 Sunflower oil Nutrition 0.000 claims description 10
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000006185 dispersion Substances 0.000 claims description 10
- 239000002600 sunflower oil Substances 0.000 claims description 10
- 238000002844 melting Methods 0.000 claims description 8
- 230000008018 melting Effects 0.000 claims description 8
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- 235000013869 carnauba wax Nutrition 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000004408 titanium dioxide Substances 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 229910021485 fumed silica Inorganic materials 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 229940049964 oleate Drugs 0.000 claims description 2
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 claims description 2
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- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 description 2
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
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- GEZAUFNYMZVOFV-UHFFFAOYSA-J 2-[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetan-2-yl)oxy]-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetane 2-oxide Chemical compound [Sn+2].[Sn+2].[O-]P([O-])(=O)OP([O-])([O-])=O GEZAUFNYMZVOFV-UHFFFAOYSA-J 0.000 description 1
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
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- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
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- 108010035532 Collagen Proteins 0.000 description 1
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 239000004150 EU approved colour Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 description 1
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- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
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- 235000004357 Mentha x piperita Nutrition 0.000 description 1
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- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
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- 244000028344 Primula vulgaris Species 0.000 description 1
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- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
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- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
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- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- YVDPOVXIRVBNAL-UHFFFAOYSA-J tetrapotassium;phosphonatooxy phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OOP([O-])([O-])=O YVDPOVXIRVBNAL-UHFFFAOYSA-J 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940071566 zinc glycinate Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
Definitions
- the present invention relates to an oral care composition comprising a pigment and also to a method for manufacturing capsules comprising a pigment.
- WO 2005/123023 A discloses toothpaste compositions comprising a dye encapsulated in wax, so that a colour change takes place when the capsule wall breaks during brushing.
- an oral care composition comprising from 0.01 to 50% by weight of the composition of a capsule, the capsule comprising a core and a coating for the core, the coating comprising a wax having a melting point of at least 70 degrees C, an oil and an opacifier and the core comprising an oil, a pigment and a shear-thinning structurant, wherein the weight ratio between the wax and the oil in the coating is from 20:80 to 80:20, preferably from 30:70 to 40:60.
- a composition provides a useful indication to the user that toothbrushing has occurred for a predetermined time, for example, the professionally recommended two minutes.
- a method of manufacturing capsules comprising pigment, said method comprising dispersing a pigment in oil and adding a shear-thinning structurant to gel the dispersion; heating an oil, a wax of melting point of at least 70 degrees C, and an opacifier to form a free flowing dispersion of the opacifier in molten wax/oil; and encapsulating the gelled dispersion of pigment in oil within the dispersion of opacifier in molten wax/oil, wherein the molten wax/oil ratio is from 20:80 to 80:20, preferably from 30:70 to 40:60.
- the nature of the capsules used in the present invention enables good containment of pigment within the capsule until shear caused during toothbrushing leads to the breakdown of the capsules and the release of the pigment.
- both the nature of the coating and the nature of the core of the capsules are important.
- the coating comprises a wax as described herein, an oil, and an opacifier and it is important that the core comprises an oil, a pigment, and a shear-thinning structurant.
- the capsules are present in an amount ranging from 0.01 to 50% by weight of the composition. Preferably, they comprise from 0.5 to 10% by weight of the composition. Such an amount provides the optimum sensory during use and also the optimum pigment release profile when the capsules are broken during toothbrushing.
- the coating of the capsules comprises from 20 to 60% of the total weight of the capsules, preferably from 30 to 50%, and more preferably around 40%.
- the wax present in the coating is preferably one with a melting point of greater than 70 degrees C, more preferably greater than 80 degrees C.
- Such waxes include carnauba wax, Chinese insect wax, candililla wax, castor wax, Japan wax, shellac, ouricouri and synthetic waxes such as high molecular weight paraffin wax and microcrystalline wax.
- the capsule coating preferably comprises from 20 to 60% by weight of wax with a melting point of greater than 70 degrees C and more preferably from 30 to 50%.
- the oil is preferably obtained from an animal, vegetable or mineral source.
- Preferred sources include vegetable sources such as fruits and plant seeds.
- Preferred oils include olive oil, borage oil, primrose oil, groundnut oil, canola oil, safflower oil, rice bran oil, peanut oil and other plant seed oils including sunflower (seed) oil.
- sunflower oil is the so-called high-oleate sunflower oil which presents a higher resistance to rancidity.
- the oil in the coating may be different to the oil in the core.
- the capsule coating preferably comprises from 35 to 75% by weight of oil and more preferably from 50 to 65%.
- the ratio between the wax and the oil in the coating is from 20:80 to 80:20, preferably from 30:70 to 40:60. These ratios provide the capsule with the best resistance to fracture during processing and also the best pigment release profile.
- the opacifier is present at an amount to mask any colour in the core, preferably this is from 1 to 10% by weight of the coating, more preferably from 3 to 7% by weight of the coating.
- the opacifier is titanium dioxide.
- the core comprises from 40 to 80% by weight of the capsule, preferably from 50 to 70% and more preferably around 60% by weight of the capsule.
- the oil is present at from 50 to 95% by weight of the core, preferably from 60 to 90 and more preferably from 70 to 80% by weight of the core.
- the core also comprises a pigment.
- the preferred pigments are blue, red, green, yellow, purple or orange. The most preferred are blue. Especially preferred are those selected from CI 14720, CI 15985, CI 16035, CI 16255, CI 19140, CI 42051, CI 42053, CI 42090, CI 47005, CI 73360, CI 74160, CI 74260, CI 75470, CI 75810, CI 77007, CI 77491 and CI 77492. These pigments present the best sensory profile during toothbrushing.
- the pigment is present at from 1 to 50% by weight of the core, preferably from 10 to 30% by weight of the core.
- the shear-thinning structurant present in the core of the capsules is important in achieving the desired delayed release of pigment.
- the presence of the shear-thinning structurant also assists the manufacture of the capsules used in the present invention.
- the shear-thinning structurant is present in the core at from 1 to 40% by weight of the core, preferably from 2 to 10 and more preferably from 4 to 6% by weight of the core.
- a preferred shear-thinning structurant is fumed silica.
- the capsules preferably have a weight average particle size of from 350 to 800 ⁇ m, more preferably from 400 to 600 ⁇ m. These present the best sensory to the user during toothbrushing.
- the capsules according to the invention provide the best pigment loading without compromising capsule integrity since the highly viscous interior core is unlikely to leak out of a capsule when the coating is breached.
- the pigment will only leak out when the capsule is completely ruptured, i.e. during brushing.
- the oral composition preferably comprises not more than 0.3% by weight pigment based on its powder weight, preferably not more than 0.2% by weight.
- the oral composition according to the invention may comprise further ingredients which are common in the art, such as:
- Liposomes may also be used to improve delivery or stability of active ingredients.
- the oral compositions may be in any form common in the art, e.g. toothpaste, gel, mousse, aerosol, gum, lozenge, powder, cream, etc. and may also be formulated into systems for use in dual-compartment type dispensers.
- Table 1 indicates the formulations of capsules as used in accordance with the present invention. Amounts of components are percentages by weight and the ratios of core:coating indicated are also by weight. Table 1 Example 1 2 3 4 Core: Olive oil -- -- 72.5 -- Sunflower oil 75 70 -- 80 Pigment 20 24 23.5 14 Fumed silica 5 6 4 6 Coating: Castor wax -- -- 40 -- Carnauba wax 38.4 32 -- 45 Sunflower oil 57.6 65 53 50 Titanium dioxide 4 3 7 5 Core:coating 50:50 40:60 70:30 60:40
- Pigment (10g) was dispersed in sunflower oil (28.8g) using an overhead stirrer. Hydrophobic fumed silica (2.5g) was then added to the dispersion in order to gel it.
- carnauba wax (19.2g) was heated to 85-90°C in order to melt it and sunflower oil (28.8g) and titanium dioxide (2g) were then mixed in using an overhead stirrer.
- the gelled dispersion of pigment and sunflower oil was stirred into water (4L) held at 85-90°C. To this mixture was added the hot carnauba wax, sunflower oil, titanium dioxide mixture, with stirring. When this addition was complete, the aqueous suspension of encapsulates was rapidly cooled to below the melting point of the carnauba wax, the encapsulates were extracted, and dried.
- a means for breaking up the dual stream of hot materials exiting the co-extrusion nozzle is employed.
- Typical means are vibratory or use pressurised, heated air.
- a cooling means is employed.
- a typical means is a cooling tunnel, although a cooled water “collection bath” may alternatively or additionally be employed.
Description
- The present invention relates to an oral care composition comprising a pigment and also to a method for manufacturing capsules comprising a pigment.
-
WO 2005/123023 A discloses toothpaste compositions comprising a dye encapsulated in wax, so that a colour change takes place when the capsule wall breaks during brushing. - In a first aspect the present invention there is provided an oral care composition comprising from 0.01 to 50% by weight of the composition of a capsule, the capsule comprising a core and a coating for the core, the coating comprising a wax having a melting point of at least 70 degrees C, an oil and an opacifier and the core comprising an oil, a pigment and a shear-thinning structurant, wherein the weight ratio between the wax and the oil in the coating is from 20:80 to 80:20, preferably from 30:70 to 40:60. Such a composition provides a useful indication to the user that toothbrushing has occurred for a predetermined time, for example, the professionally recommended two minutes.
- In a second aspect of the present invention, there is provided a method of manufacturing capsules comprising pigment, said method comprising dispersing a pigment in oil and adding a shear-thinning structurant to gel the dispersion; heating an oil, a wax of melting point of at least 70 degrees C, and an opacifier to form a free flowing dispersion of the opacifier in molten wax/oil; and encapsulating the gelled dispersion of pigment in oil within the dispersion of opacifier in molten wax/oil, wherein the molten wax/oil ratio is from 20:80 to 80:20, preferably from 30:70 to 40:60.
- The nature of the capsules used in the present invention enables good containment of pigment within the capsule until shear caused during toothbrushing leads to the breakdown of the capsules and the release of the pigment. For the capsules to function in the correct manner, showing colour only after the desired time, both the nature of the coating and the nature of the core of the capsules are important. Thus, it is important that the coating comprises a wax as described herein, an oil, and an opacifier and it is important that the core comprises an oil, a pigment, and a shear-thinning structurant.
- The capsules are present in an amount ranging from 0.01 to 50% by weight of the composition. Preferably, they comprise from 0.5 to 10% by weight of the composition. Such an amount provides the optimum sensory during use and also the optimum pigment release profile when the capsules are broken during toothbrushing.
- Typically, the coating of the capsules comprises from 20 to 60% of the total weight of the capsules, preferably from 30 to 50%, and more preferably around 40%.
- The wax present in the coating is preferably one with a melting point of greater than 70 degrees C, more preferably greater than 80 degrees C. Such waxes include carnauba wax, Chinese insect wax, candililla wax, castor wax, Japan wax, shellac, ouricouri and synthetic waxes such as high molecular weight paraffin wax and microcrystalline wax.
- The capsule coating preferably comprises from 20 to 60% by weight of wax with a melting point of greater than 70 degrees C and more preferably from 30 to 50%.
- The oil, both in the coating and in the core, is preferably obtained from an animal, vegetable or mineral source. Preferred sources include vegetable sources such as fruits and plant seeds. Preferred oils include olive oil, borage oil, primrose oil, groundnut oil, canola oil, safflower oil, rice bran oil, peanut oil and other plant seed oils including sunflower (seed) oil. The most preferred sunflower oil is the so-called high-oleate sunflower oil which presents a higher resistance to rancidity.
- The oil in the coating may be different to the oil in the core.
- The capsule coating preferably comprises from 35 to 75% by weight of oil and more preferably from 50 to 65%.
- The ratio between the wax and the oil in the coating is from 20:80 to 80:20, preferably from 30:70 to 40:60. These ratios provide the capsule with the best resistance to fracture during processing and also the best pigment release profile.
- Preferably the opacifier is present at an amount to mask any colour in the core, preferably this is from 1 to 10% by weight of the coating, more preferably from 3 to 7% by weight of the coating. Preferably the opacifier is titanium dioxide.
- Typically, the core comprises from 40 to 80% by weight of the capsule, preferably from 50 to 70% and more preferably around 60% by weight of the capsule.
- The oil is present at from 50 to 95% by weight of the core, preferably from 60 to 90 and more preferably from 70 to 80% by weight of the core.
- The core also comprises a pigment. The preferred pigments are blue, red, green, yellow, purple or orange. The most preferred are blue. Especially preferred are those selected from CI 14720, CI 15985, CI 16035, CI 16255, CI 19140, CI 42051, CI 42053, CI 42090, CI 47005, CI 73360, CI 74160, CI 74260, CI 75470, CI 75810, CI 77007, CI 77491 and CI 77492. These pigments present the best sensory profile during toothbrushing.
- The pigment is present at from 1 to 50% by weight of the core, preferably from 10 to 30% by weight of the core.
- The shear-thinning structurant present in the core of the capsules is important in achieving the desired delayed release of pigment. The presence of the shear-thinning structurant also assists the manufacture of the capsules used in the present invention.
- The shear-thinning structurant is present in the core at from 1 to 40% by weight of the core, preferably from 2 to 10 and more preferably from 4 to 6% by weight of the core.
- A preferred shear-thinning structurant is fumed silica. The capsules preferably have a weight average particle size of from 350 to 800 µm, more preferably from 400 to 600 µm. These present the best sensory to the user during toothbrushing.
- The capsules according to the invention provide the best pigment loading without compromising capsule integrity since the highly viscous interior core is unlikely to leak out of a capsule when the coating is breached. The pigment will only leak out when the capsule is completely ruptured, i.e. during brushing.
- The oral composition preferably comprises not more than 0.3% by weight pigment based on its powder weight, preferably not more than 0.2% by weight.
- The oral composition according to the invention may comprise further ingredients which are common in the art, such as:
- antimicrobial agents, e.g. Triclosan, chlorhexidine, copper, zinc, and stannous salts such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis-(4-chloro-6-bromophenol);
- anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.;
- anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein;
- plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates;
- vitamins such as Vitamins A, C and E;
- plant extracts;
- desensitising agents, e.g. potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts;
- anti-calculus agents, e.g. alkali-metal pyrophosphates, hypophosphite-containing polymers, organic phosphonates and phosphocitrates etc.;
- biomolecules, e.g. bacteriocins, antibodies, enzymes, etc.;
- flavours, e.g. peppermint and spearmint oils;
- proteinaceous materials such as collagen;
- preservatives;
- opacifying agents;
- colouring agents;
- pH-adjusting agents;
- sweetening agents;
- pharmaceutically acceptable carriers, e.g. starch, sucrose, water or water/alcohol systems etc.;
- surfactants, such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants;
- particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including capsuled particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
- humectants such as glycerol, sorbitol, propyleneglycol, xylitol, lactitol etc.;
- binders and thickeners such as sodium carboxymethylcellulose, xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol®;
- polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included. Examples of such polymers are copolymers of polyvinylmethylether with maleic anhydride and other similar delivery enhancing polymers, e.g. those described in
DE-A-3,942,643 (Colgate ); - buffers and salts to buffer the pH and ionic strength of the oral care composition; and other optional ingredients that may be included are e.g. bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
- Liposomes may also be used to improve delivery or stability of active ingredients.
- The oral compositions may be in any form common in the art, e.g. toothpaste, gel, mousse, aerosol, gum, lozenge, powder, cream, etc. and may also be formulated into systems for use in dual-compartment type dispensers.
- Table 1 indicates the formulations of capsules as used in accordance with the present invention. Amounts of components are percentages by weight and the ratios of core:coating indicated are also by weight.
Table 1 Example 1 2 3 4 Core: Olive oil -- -- 72.5 -- Sunflower oil 75 70 -- 80 Pigment 20 24 23.5 14 Fumed silica 5 6 4 6 Coating: Castor wax -- -- 40 -- Carnauba wax 38.4 32 -- 45 Sunflower oil 57.6 65 53 50 Titanium dioxide 4 3 7 5 Core:coating 50:50 40:60 70:30 60:40 - The following process was used to make the capsules of Example 1.
- Pigment (10g) was dispersed in sunflower oil (28.8g) using an overhead stirrer. Hydrophobic fumed silica (2.5g) was then added to the dispersion in order to gel it.
- In a separate vessel, carnauba wax (19.2g) was heated to 85-90°C in order to melt it and sunflower oil (28.8g) and titanium dioxide (2g) were then mixed in using an overhead stirrer.
- The gelled dispersion of pigment and sunflower oil was stirred into water (4L) held at 85-90°C. To this mixture was added the hot carnauba wax, sunflower oil, titanium dioxide mixture, with stirring. When this addition was complete, the aqueous suspension of encapsulates was rapidly cooled to below the melting point of the carnauba wax, the encapsulates were extracted, and dried.
- In an alternative process of manufacture, applicable to all co-extrusion encapsulation is used. In this process, there are two hot feeds (jacketed lines or electrical heat traced) that feed, via controllable pumps, to a co-extrusion nozzle consisting of an internal tube carrying core material and an external tube carrying the coating material. The nozzle generally has a heating means in order to prevent solidification of the molten wax in the coating.
- To control the particle size of the capsules, a means for breaking up the dual stream of hot materials exiting the co-extrusion nozzle is employed. Typical means are vibratory or use pressurised, heated air.
- To solidify the encapsulates, a cooling means is employed. A typical means is a cooling tunnel, although a cooled water "collection bath" may alternatively or additionally be employed.
Claims (12)
- An oral care composition comprising from 0.01 to 50% by weight of the composition of a capsule, the capsule comprising a core and a coating for the core, the coating comprising a wax having a melting point of at least 70 degrees C, an oil and an opacifier and the core comprising an oil, a pigment and a shear-thinning structurant, wherein the weight ratio between the wax and the oil in the coating is from 20:80 to 80:20, preferably from 30:70 to 40:60.
- An oral care composition according to claim 1 wherein the wax has a melting point of at least 80 degrees C.
- An oral care composition according to claim 1 or 2 wherein the oil is sunflower oil.
- An oral care composition according to any preceding claim wherein the oil is high-oleate sunflower oil.
- An oral care composition according to any preceding claim wherein the wax is carnauba wax.
- An oral care composition according to any preceding claim wherein the opacifier is titanium dioxide.
- An oral care composition according to any preceding claim wherein the shear thinning structurant is fumed silica.
- An oral care composition according to any preceding claim wherein the pigment is selected from - CI 14720, CI 15985, CI 16035, CI 16255, CI 19140, CI 42051, CI 42053, CI 42090, CI 47005, CI 73360, CI 74160, CI 74260, CI 75470, CI 75810, CI 77007, CI 77491 and CI 77492.
- An oral care composition according to any preceding claim wherein the weight average particle size of the capsules is from 350 to 800 µm, preferably from 400 to 600 µm.
- An oral care composition according to any preceding claim wherein the total amount of pigment is not greater than 0.3% by weight, preferably not more than 0.2% by weight.
- An oral care composition according to any preceding claim wherein the composition comprises a first phase and a second phase and wherein the capsule is present in only the first phase.
- A method of manufacturing capsules comprising pigment, said method comprising dispersing a pigment in oil and adding a shear-thinning structurant to gel the dispersion; heating an oil, a wax of melting point of at least 70 degrees C, and an opacifier to form a free flowing dispersion of the opacifier in molten wax/oil; and encapsulating the gelled dispersion of pigment in oil within the dispersion of opacifier in molten wax/oil, wherein the molten wax/oil weight ratio is from 20:80 to 80:20, preferably from 30:70 to 40:60.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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EP07788033.4A EP2046268B2 (en) | 2006-08-03 | 2007-07-30 | Oral care composition |
PL07788033T PL2046268T5 (en) | 2006-08-03 | 2007-07-30 | Oral care composition |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP06118389 | 2006-08-03 | ||
PCT/EP2007/057829 WO2008015186A1 (en) | 2006-08-03 | 2007-07-30 | Oral care composition |
EP07788033.4A EP2046268B2 (en) | 2006-08-03 | 2007-07-30 | Oral care composition |
Publications (3)
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EP2046268A1 EP2046268A1 (en) | 2009-04-15 |
EP2046268B1 EP2046268B1 (en) | 2013-02-27 |
EP2046268B2 true EP2046268B2 (en) | 2016-07-13 |
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Application Number | Title | Priority Date | Filing Date |
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EP07788033.4A Active EP2046268B2 (en) | 2006-08-03 | 2007-07-30 | Oral care composition |
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US (1) | US20090297570A1 (en) |
EP (1) | EP2046268B2 (en) |
CN (1) | CN101495084B (en) |
BR (1) | BRPI0713831B1 (en) |
CL (1) | CL2007002250A1 (en) |
MX (1) | MX2009001228A (en) |
PL (1) | PL2046268T5 (en) |
WO (1) | WO2008015186A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT202000032072A1 (en) * | 2020-12-23 | 2022-06-23 | Melo S R L | CAPSULE CONTAINING A LIQUID TOOTHPASTE |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2932980B1 (en) * | 2008-06-27 | 2010-12-24 | Oreal | COSMETIC COMPOSITION FOR MAKE-UP AND / OR LIP CARE |
EP3384896B1 (en) | 2010-07-19 | 2020-10-14 | Colgate-Palmolive Company | Cleansing composition with 4-oxovaleric acid and leuconostoc/radish root ferment filtrate |
CN106963662B (en) * | 2017-03-15 | 2020-05-12 | 广州薇美姿实业有限公司 | Color-changing toothpaste for children and preparation method and application thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2124311A1 (en) † | 1971-02-01 | 1972-09-22 | Henkel & Cie Gmbh | Toothpaste - contains wax particles protecting active ingredients from deterioration and loss of flavour |
US3929988A (en) † | 1974-06-21 | 1975-12-30 | Colgate Palmolive Co | Flavored dentifrice |
US4196189A (en) † | 1977-03-19 | 1980-04-01 | Blendax-Werke R. Schneider | Dental and oral hygiene preparations |
US4202878A (en) † | 1974-09-20 | 1980-05-13 | The Procter & Gamble Company | Compositions of matter for coloring toothpaste and method of preparing same |
US5700449A (en) † | 1994-10-18 | 1997-12-23 | Kao Corporation | Dentifrice composition |
US6238690B1 (en) † | 1995-03-29 | 2001-05-29 | Warner-Lambert Company | Food products containing seamless capsules and methods of making the same |
US20020048553A1 (en) † | 2000-08-17 | 2002-04-25 | Irene Baumgartner | Toothpaste |
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US3914405A (en) * | 1966-07-26 | 1975-10-21 | Nat Patent Dev Corp | Cosmetic and toothpaste preparations |
DE2238332A1 (en) * | 1972-08-04 | 1974-02-14 | Blendax Werke Schneider Co | TOOTHPASTE |
US3839064A (en) * | 1972-09-21 | 1974-10-01 | Champion Int Corp | Inorganic pigment-loaded polymeric microcapsular system |
US4071614A (en) * | 1975-06-03 | 1978-01-31 | Colgate Palmolive Company | Dentifrice containing encapsulated flavoring |
US6060084A (en) * | 1997-08-28 | 2000-05-09 | Cannon Chemical Company | Method for preparing a core material containment system and the core material containment system prepared thereby |
KR100598871B1 (en) * | 2001-09-10 | 2006-07-12 | 에프. 호프만-라 로슈 아게 | Oily thixotropic formulations |
US20040185093A1 (en) * | 2003-03-18 | 2004-09-23 | Szymczak Christopher E. | Compositions containing sucralose |
CA2570015A1 (en) * | 2004-06-10 | 2005-12-29 | Segan Industries, Inc. | Plural activating optical change toothpastes, stimuli and elements |
US20080187497A1 (en) * | 2005-02-04 | 2008-08-07 | Rupesh Kumar Agarwal | Toothpaste |
-
2007
- 2007-07-30 BR BRPI0713831A patent/BRPI0713831B1/en active IP Right Grant
- 2007-07-30 US US12/309,891 patent/US20090297570A1/en not_active Abandoned
- 2007-07-30 MX MX2009001228A patent/MX2009001228A/en active IP Right Grant
- 2007-07-30 PL PL07788033T patent/PL2046268T5/en unknown
- 2007-07-30 WO PCT/EP2007/057829 patent/WO2008015186A1/en active Application Filing
- 2007-07-30 CN CN2007800280439A patent/CN101495084B/en active Active
- 2007-07-30 EP EP07788033.4A patent/EP2046268B2/en active Active
- 2007-08-02 CL CL200702250A patent/CL2007002250A1/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2124311A1 (en) † | 1971-02-01 | 1972-09-22 | Henkel & Cie Gmbh | Toothpaste - contains wax particles protecting active ingredients from deterioration and loss of flavour |
US3929988A (en) † | 1974-06-21 | 1975-12-30 | Colgate Palmolive Co | Flavored dentifrice |
US4202878A (en) † | 1974-09-20 | 1980-05-13 | The Procter & Gamble Company | Compositions of matter for coloring toothpaste and method of preparing same |
US4196189A (en) † | 1977-03-19 | 1980-04-01 | Blendax-Werke R. Schneider | Dental and oral hygiene preparations |
US5700449A (en) † | 1994-10-18 | 1997-12-23 | Kao Corporation | Dentifrice composition |
US6238690B1 (en) † | 1995-03-29 | 2001-05-29 | Warner-Lambert Company | Food products containing seamless capsules and methods of making the same |
US20020048553A1 (en) † | 2000-08-17 | 2002-04-25 | Irene Baumgartner | Toothpaste |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT202000032072A1 (en) * | 2020-12-23 | 2022-06-23 | Melo S R L | CAPSULE CONTAINING A LIQUID TOOTHPASTE |
Also Published As
Publication number | Publication date |
---|---|
US20090297570A1 (en) | 2009-12-03 |
PL2046268T5 (en) | 2017-07-31 |
CL2007002250A1 (en) | 2008-04-04 |
EP2046268A1 (en) | 2009-04-15 |
PL2046268T3 (en) | 2013-07-31 |
BRPI0713831B1 (en) | 2015-11-24 |
WO2008015186A1 (en) | 2008-02-07 |
CN101495084B (en) | 2012-04-11 |
CN101495084A (en) | 2009-07-29 |
EP2046268B1 (en) | 2013-02-27 |
BRPI0713831A2 (en) | 2012-12-25 |
MX2009001228A (en) | 2009-02-11 |
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