EP2035441A4 - Cyanocobalamin low viscosity aqueous formulations for intranasal delivery - Google Patents

Cyanocobalamin low viscosity aqueous formulations for intranasal delivery

Info

Publication number: EP2035441A4
Authority: EP; European Patent Office
Prior art keywords: cyanocobalamin; low viscosity; aqueous formulations; intranasal delivery; viscosity aqueous
Prior art date: 2006-06-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP06785533A

Other languages

German (de)

French (fr)

Other versions

EP2035441A1 (en

Inventor

Steven C Quay

Zenaida O Go

Peter C Aprile

Antony P Sileno

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Par Pharmaceuticals Inc

Original Assignee

Par Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-23

Filing date

2006-06-23

Publication date

2013-01-16

2006-06-23 Application filed by Par Pharmaceuticals Inc filed Critical Par Pharmaceuticals Inc

2009-03-18 Publication of EP2035441A1 publication Critical patent/EP2035441A1/en

2013-01-16 Publication of EP2035441A4 publication Critical patent/EP2035441A4/en

Status Ceased legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

EP06785533A 2006-06-23 2006-06-23 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery Ceased EP2035441A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2006/024685 WO2007149098A1 (en)	2006-06-23	2006-06-23	Cyanocobalamin low viscosity aqueous formulations for intranasal delivery

Publications (2)

Publication Number	Publication Date
EP2035441A1 EP2035441A1 (en)	2009-03-18
EP2035441A4 true EP2035441A4 (en)	2013-01-16

Family

ID=38833714

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP06785533A Ceased EP2035441A4 (en)	2006-06-23	2006-06-23	Cyanocobalamin low viscosity aqueous formulations for intranasal delivery

Country Status (10)

Country	Link
EP (1)	EP2035441A4 (en)
JP (1)	JP5769924B2 (en)
KR (3)	KR20140101010A (en)
CN (1)	CN101600729A (en)
AU (1)	AU2006344733B2 (en)
CA (1)	CA2656823C (en)
IL (2)	IL196038A (en)
NO (1)	NO20090368L (en)
WO (1)	WO2007149098A1 (en)
ZA (1)	ZA200900191B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP3814A (en) *	2010-10-29	2016-09-30	Troikaa Pharmaceuticals Ltd	Nasal compositions of vitamin b12
EP3589269B1 (en) *	2017-03-02	2021-04-07	Dutch Renewable Energy B.V.	Intranasal administration of physiologically active substances
US20220111162A1 (en) *	2020-07-29	2022-04-14	Lido Ventures Llc	Apparatus, system, and method for facilitating intranasal treatment of a patient

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1986005987A1 (en) *	1985-04-16	1986-10-23	Nastech Pharmaceutical Company, Inc.	Aerosol compositions for nasal delivery of vitamin b12
US5112804A (en) *	1987-04-01	1992-05-12	Temple University Of The Commonwealth System Of Higher Education	Pharmaceutical composition and method of intranasal administration
WO1995017164A1 (en) *	1993-12-20	1995-06-29	Merkus Franciscus W H M	A pharmaceutical composition for the intranasal administration of hydroxocobalamin
WO2000033810A1 (en) *	1998-12-09	2000-06-15	Biovector Therapeutics (S.A.)	Use of vitamin b12 in a nasal composition for delivering active agents to the central nervous system
WO2007022345A2 (en) *	2005-08-17	2007-02-22	Fleming And Company, Pharmaceuticals	Vitamin b12 nasal spray and method of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4724231A (en) *	1985-04-16	1988-02-09	Nastech Pharmaceutical, Inc.	Nasel compositions containing vitamin B12
US4959176A (en) *	1988-04-29	1990-09-25	Beckman Instruments, Inc.	High resolution non corrosive amino acid analysis buffer solutions
US5227311A (en) *	1988-10-11	1993-07-13	Abbott Laboratories	Intrinsic factor to determine B12
US6406730B1 (en) *	1998-12-01	2002-06-18	Carl E. Banyard	Process for producing low acid food products
SK3232003A3 (en) *	2000-09-20	2004-02-03	Nycomed Pharma As	Preparation of vitamin emulsions and concentrates thereof
US20060074034A1 (en) *	2001-09-17	2006-04-06	Collins Douglas A	Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
US6911434B2 (en) *	2002-02-04	2005-06-28	Corixa Corporation	Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
US20040109826A1 (en) *	2002-12-06	2004-06-10	Dey, L.P.	Stabilized albuterol compositions and method of preparation thereof
DE10300719A1 (en) *	2003-01-11	2004-07-22	Basf Ag	Improved process for the production of vitamin B12
US20060127320A1 (en) *	2004-05-10	2006-06-15	Nastech Pharmaceutical Company Inc.	Method of delivering parathyroid hormone to a human
US20060046969A1 (en) *	2004-08-25	2006-03-02	Aegis Therapeutics Llc	Antibacterial compositions for drug administration

2006
- 2006-06-23 JP JP2009516468A patent/JP5769924B2/en not_active Expired - Fee Related
- 2006-06-23 CN CNA2006800556586A patent/CN101600729A/en active Pending
- 2006-06-23 WO PCT/US2006/024685 patent/WO2007149098A1/en active Application Filing
- 2006-06-23 KR KR1020147021098A patent/KR20140101010A/en not_active Application Discontinuation
- 2006-06-23 AU AU2006344733A patent/AU2006344733B2/en not_active Ceased
- 2006-06-23 EP EP06785533A patent/EP2035441A4/en not_active Ceased
- 2006-06-23 KR KR1020177023153A patent/KR20170098977A/en not_active Application Discontinuation
- 2006-06-23 KR KR1020097001414A patent/KR20090074722A/en not_active Application Discontinuation
- 2006-06-23 CA CA2656823A patent/CA2656823C/en not_active Expired - Fee Related
2008
- 2008-12-18 IL IL196038A patent/IL196038A/en active IP Right Grant
2009
- 2009-01-09 ZA ZA2009/00191A patent/ZA200900191B/en unknown
- 2009-01-23 NO NO20090368A patent/NO20090368L/en not_active Application Discontinuation
2016
- 2016-10-21 IL IL248447A patent/IL248447B/en unknown

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1986005987A1 (en) *	1985-04-16	1986-10-23	Nastech Pharmaceutical Company, Inc.	Aerosol compositions for nasal delivery of vitamin b12
US5112804A (en) *	1987-04-01	1992-05-12	Temple University Of The Commonwealth System Of Higher Education	Pharmaceutical composition and method of intranasal administration
WO1995017164A1 (en) *	1993-12-20	1995-06-29	Merkus Franciscus W H M	A pharmaceutical composition for the intranasal administration of hydroxocobalamin
WO2000033810A1 (en) *	1998-12-09	2000-06-15	Biovector Therapeutics (S.A.)	Use of vitamin b12 in a nasal composition for delivering active agents to the central nervous system
WO2007022345A2 (en) *	2005-08-17	2007-02-22	Fleming And Company, Pharmaceuticals	Vitamin b12 nasal spray and method of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2007149098A1 *

Also Published As

Publication number	Publication date
IL248447A0 (en)	2016-11-30
KR20090074722A (en)	2009-07-07
JP5769924B2 (en)	2015-08-26
JP2009541312A (en)	2009-11-26
CA2656823C (en)	2015-02-03
AU2006344733A1 (en)	2007-12-27
KR20170098977A (en)	2017-08-30
KR20140101010A (en)	2014-08-18
CA2656823A1 (en)	2007-12-27
NO20090368L (en)	2009-03-23
AU2006344733B2 (en)	2014-02-27
IL196038A0 (en)	2009-09-01
WO2007149098A1 (en)	2007-12-27
IL196038A (en)	2016-10-31
IL248447B (en)	2021-10-31
EP2035441A1 (en)	2009-03-18
CN101600729A (en)	2009-12-09
ZA200900191B (en)	2012-09-26

Legal Events

Date	Code	Title	Description
2009-02-13	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2009-03-18	17P	Request for examination filed	Effective date: 20081231
2009-03-18	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
2009-03-18	AX	Request for extension of the european patent	Extension state: AL BA HR MK RS
2009-06-24	RIN1	Information on inventor provided before grant (corrected)	Inventor name: SILENO, ANTONY, P. Inventor name: APRILE, PETER, C. Inventor name: GO, ZENAIDA, O. Inventor name: QUAY, STEVEN, C.
2009-08-19	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: PAR PHARMACEUTICALS, INC.
2009-10-21	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: PAR PHARMACEUTICAL, INC.
2009-10-23	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1128294 Country of ref document: HK
2012-07-25	DAX	Request for extension of the european patent (deleted)
2013-01-16	A4	Supplementary search report drawn up and despatched	Effective date: 20121218
2013-01-16	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 9/08 20060101ALI20121212BHEP Ipc: A61K 31/714 20060101AFI20121212BHEP Ipc: A61K 47/10 20060101ALI20121212BHEP
2014-04-23	17Q	First examination report despatched	Effective date: 20140325
2016-11-02	APBK	Appeal reference recorded	Free format text: ORIGINAL CODE: EPIDOSNREFNE
2016-11-02	APBN	Date of receipt of notice of appeal recorded	Free format text: ORIGINAL CODE: EPIDOSNNOA2E
2017-01-03	APBR	Date of receipt of statement of grounds of appeal recorded	Free format text: ORIGINAL CODE: EPIDOSNNOA3E
2017-02-03	APAF	Appeal reference modified	Free format text: ORIGINAL CODE: EPIDOSCREFNE
2020-08-22	APBT	Appeal procedure closed	Free format text: ORIGINAL CODE: EPIDOSNNOA9E
2020-09-05	REG	Reference to a national code	Ref country code: DE Ref legal event code: R003
2020-09-11	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2020-10-14	18R	Application refused	Effective date: 20200905
2023-01-20	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1128294 Country of ref document: HK

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