EP1933760A4 - Compositions and methods of administering rapamycin analogs with paclitaxel using medical devices - Google Patents

Compositions and methods of administering rapamycin analogs with paclitaxel using medical devices

Info

Publication number
EP1933760A4
EP1933760A4 EP06825887A EP06825887A EP1933760A4 EP 1933760 A4 EP1933760 A4 EP 1933760A4 EP 06825887 A EP06825887 A EP 06825887A EP 06825887 A EP06825887 A EP 06825887A EP 1933760 A4 EP1933760 A4 EP 1933760A4
Authority
EP
European Patent Office
Prior art keywords
paclitaxel
compositions
methods
medical devices
rapamycin analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06825887A
Other languages
German (de)
French (fr)
Other versions
EP1933760A2 (en
Inventor
Sandra E Burke
Keith R Cromack
Matthew Mack
John L Toner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP1933760A2 publication Critical patent/EP1933760A2/en
Publication of EP1933760A4 publication Critical patent/EP1933760A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
EP06825887A 2005-10-14 2006-10-12 Compositions and methods of administering rapamycin analogs with paclitaxel using medical devices Withdrawn EP1933760A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72708005P 2005-10-14 2005-10-14
US72687805P 2005-10-14 2005-10-14
US72719605P 2005-10-14 2005-10-14
US73257705P 2005-10-17 2005-10-17
PCT/US2006/040027 WO2007047416A2 (en) 2005-10-14 2006-10-12 Compositions and methods of administering rapamycin analogs with paclitaxel using medical devices

Publications (2)

Publication Number Publication Date
EP1933760A2 EP1933760A2 (en) 2008-06-25
EP1933760A4 true EP1933760A4 (en) 2009-08-12

Family

ID=37962960

Family Applications (3)

Application Number Title Priority Date Filing Date
EP20060813474 Active EP1933785B1 (en) 2005-10-14 2006-08-15 Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
EP06825887A Withdrawn EP1933760A4 (en) 2005-10-14 2006-10-12 Compositions and methods of administering rapamycin analogs with paclitaxel using medical devices
EP06816907.7A Active EP1933759B1 (en) 2005-10-14 2006-10-12 Methods of administering rapamycin analogs with anti-inflammatories using medical devices

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20060813474 Active EP1933785B1 (en) 2005-10-14 2006-08-15 Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP06816907.7A Active EP1933759B1 (en) 2005-10-14 2006-10-12 Methods of administering rapamycin analogs with anti-inflammatories using medical devices

Country Status (4)

Country Link
EP (3) EP1933785B1 (en)
JP (3) JP5285426B2 (en)
TW (1) TWI435724B (en)
WO (3) WO2007046935A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060198867A1 (en) * 1997-09-25 2006-09-07 Abbott Laboratories, Inc. Compositions and methods of administering rapamycin analogs using medical devices for long-term efficacy
US8257726B2 (en) 1997-09-26 2012-09-04 Abbott Laboratories Compositions, systems, kits, and methods of administering rapamycin analogs with paclitaxel using medical devices
US8057816B2 (en) * 1997-09-26 2011-11-15 Abbott Laboratories Compositions and methods of administering paclitaxel with other drugs using medical devices
US7378105B2 (en) 1997-09-26 2008-05-27 Abbott Laboratories Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens
US7357942B2 (en) 1997-09-26 2008-04-15 Abbott Laboratories Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens
US20100030183A1 (en) * 2004-03-19 2010-02-04 Toner John L Method of treating vascular disease at a bifurcated vessel using a coated balloon
US8431145B2 (en) * 2004-03-19 2013-04-30 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
JP5541593B2 (en) * 2006-08-15 2014-07-09 アボット ラボラトリーズ Composition and drug delivery system comprising rapamycin analog and paclitaxel
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
WO2008063576A2 (en) * 2006-11-20 2008-05-29 Lutonix, Inc. Drug releasing coatings for medical devices
WO2009031295A1 (en) 2007-09-04 2009-03-12 Japan Stent Technology Co., Ltd. Stent for controlled drug release
US8500687B2 (en) 2008-09-25 2013-08-06 Abbott Cardiovascular Systems Inc. Stent delivery system having a fibrous matrix covering with improved stent retention
US8092822B2 (en) * 2008-09-29 2012-01-10 Abbott Cardiovascular Systems Inc. Coatings including dexamethasone derivatives and analogs and olimus drugs
US8709465B2 (en) * 2009-04-13 2014-04-29 Medtronic Vascular, Inc. Diazeniumdiolated phosphorylcholine polymers for nitric oxide release
JP5693456B2 (en) 2009-08-26 2015-04-01 大塚メディカルデバイス株式会社 Intraluminal medical device and method for manufacturing the same
US8951595B2 (en) 2009-12-11 2015-02-10 Abbott Cardiovascular Systems Inc. Coatings with tunable molecular architecture for drug-coated balloon
US20110319976A1 (en) * 2010-01-27 2011-12-29 Sriram Iyer Device and method for preventing stenosis at an anastomosis site
ES2797376T3 (en) 2013-01-24 2020-12-02 Palvella Therapeutics Inc Compositions for the transdermal administration of mTOR inhibitors
WO2016067994A1 (en) 2014-10-28 2016-05-06 株式会社Jimro Drug-eluting stent
IL302385B1 (en) 2017-01-06 2024-02-01 Palvella Therapeutics Inc Anhydrous compositions of mtor inhibitors and methods of use
EP3817743A4 (en) 2018-07-02 2022-07-06 Palvella Therapeutics, Inc. Anhydrous compositions of mtor inhibitors and methods of use
EP4225390A1 (en) * 2020-10-06 2023-08-16 Ul1sse Innovative Solutions S.r.l. Therapeutic agent for use in local treatment of inflammation associated with atherosclerosis and/or a thrombotic state

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087372A1 (en) * 2000-05-12 2001-11-22 Cordis Corporation Drug combinations useful for prevention of restenosis
US20050019404A1 (en) * 2003-06-30 2005-01-27 Hsing-Wen Sung Drug-eluting biodegradable stent
WO2006116348A2 (en) * 2005-04-26 2006-11-02 Advanced Cardiovascular Systems, Inc. Compositions for medical devices containing agent combinations in controlled volumes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US6200335B1 (en) 1997-03-31 2001-03-13 Kabushikikaisha Igaki Iryo Sekkei Stent for vessel
US20030129215A1 (en) * 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
US6015815A (en) * 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US6890546B2 (en) * 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
US20050004158A1 (en) * 2003-06-19 2005-01-06 Vascular Therapies Llc Medical implants and methods for regulating the tissue response to vascular closure devices
MXPA03006315A (en) * 2001-01-16 2004-12-03 Vascular Therapies Llc Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts.
DE50210591D1 (en) * 2001-02-16 2007-09-13 Abbott Lab Vascular Entpr Ltd IMPLANTS WITH FK506 FOR RESTENOSIS TREATMENT AND PROPHYLAXIS
US20040024448A1 (en) * 2002-08-05 2004-02-05 Chang James W. Thermoplastic fluoropolymer-coated medical devices
KR101012605B1 (en) * 2002-09-06 2011-02-10 아보트 러보러터리즈 Medical device having hydration inhibitor
US7758881B2 (en) * 2004-06-30 2010-07-20 Advanced Cardiovascular Systems, Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US20040236415A1 (en) * 2003-01-02 2004-11-25 Richard Thomas Medical devices having drug releasing polymer reservoirs
US8828416B2 (en) * 2004-03-09 2014-09-09 Cordis Corporation Local vascular delivery of topotecan in combination with rapamycin to prevent restenosis following vascular injury
AU2005222719B2 (en) * 2004-03-19 2011-03-24 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
US20050208093A1 (en) * 2004-03-22 2005-09-22 Thierry Glauser Phosphoryl choline coating compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087372A1 (en) * 2000-05-12 2001-11-22 Cordis Corporation Drug combinations useful for prevention of restenosis
US20050019404A1 (en) * 2003-06-30 2005-01-27 Hsing-Wen Sung Drug-eluting biodegradable stent
WO2006116348A2 (en) * 2005-04-26 2006-11-02 Advanced Cardiovascular Systems, Inc. Compositions for medical devices containing agent combinations in controlled volumes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEVIN ANDREW D ET AL: "Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, no. 25, 22 June 2004 (2004-06-22), pages 9463 - 9467, XP002532740, ISSN: 0027-8424 *
VAN DER HOEVEN B L ET AL: "Drug-eluting stents: results, promises and problems", INTERNATIONAL JOURNAL OF CARDIOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 99, no. 1, 10 March 2005 (2005-03-10), pages 9 - 17, XP025256932, ISSN: 0167-5273, [retrieved on 20050310] *

Also Published As

Publication number Publication date
WO2007046935A3 (en) 2007-07-05
JP5225849B2 (en) 2013-07-03
JP5285426B2 (en) 2013-09-11
EP1933759A2 (en) 2008-06-25
TWI435724B (en) 2014-05-01
JP2009511205A (en) 2009-03-19
EP1933759B1 (en) 2014-12-17
TW200800196A (en) 2008-01-01
WO2007047473A3 (en) 2007-08-09
JP5307546B2 (en) 2013-10-02
EP1933785B1 (en) 2015-04-22
JP2009511165A (en) 2009-03-19
EP1933759A4 (en) 2009-08-05
WO2007047473A2 (en) 2007-04-26
EP1933785A2 (en) 2008-06-25
EP1933760A2 (en) 2008-06-25
WO2007047416A3 (en) 2007-11-08
WO2007046935A2 (en) 2007-04-26
JP2009511195A (en) 2009-03-19
EP1933785A4 (en) 2009-07-29
WO2007047416A2 (en) 2007-04-26

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