EP1931387A4 - Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates - Google Patents

Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates

Info

Publication number
EP1931387A4
EP1931387A4 EP06803043A EP06803043A EP1931387A4 EP 1931387 A4 EP1931387 A4 EP 1931387A4 EP 06803043 A EP06803043 A EP 06803043A EP 06803043 A EP06803043 A EP 06803043A EP 1931387 A4 EP1931387 A4 EP 1931387A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical formulations
release rates
exhibiting improved
improved release
biodegradable microparticle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06803043A
Other languages
German (de)
French (fr)
Other versions
EP1931387A2 (en
Inventor
Eliot M Slovin
Joseph T Persyn
Joseph A Mcdonough
Neal K Vail
Darren E Barlow
Albert M Zwiener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Southwest Research Institute SwRI
Original Assignee
Southwest Research Institute SwRI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/220,430 external-priority patent/US7758778B2/en
Priority claimed from US11/220,807 external-priority patent/US9693967B2/en
Priority claimed from US11/221,337 external-priority patent/US7261529B2/en
Application filed by Southwest Research Institute SwRI filed Critical Southwest Research Institute SwRI
Publication of EP1931387A2 publication Critical patent/EP1931387A2/en
Publication of EP1931387A4 publication Critical patent/EP1931387A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
EP06803043A 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates Withdrawn EP1931387A4 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22043105A 2005-09-07 2005-09-07
US22044505A 2005-09-07 2005-09-07
US11/220,430 US7758778B2 (en) 2005-09-07 2005-09-07 Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US11/220,807 US9693967B2 (en) 2005-09-07 2005-09-07 Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US11/221,337 US7261529B2 (en) 2005-09-07 2005-09-07 Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
PCT/US2006/034722 WO2007030545A2 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates

Publications (2)

Publication Number Publication Date
EP1931387A2 EP1931387A2 (en) 2008-06-18
EP1931387A4 true EP1931387A4 (en) 2012-07-11

Family

ID=37836422

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06803043A Withdrawn EP1931387A4 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates

Country Status (7)

Country Link
EP (1) EP1931387A4 (en)
JP (1) JP2009507845A (en)
KR (1) KR20080059175A (en)
AU (1) AU2006287499A1 (en)
BR (1) BRPI0615563A2 (en)
CA (1) CA2621395A1 (en)
WO (1) WO2007030545A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2956345B1 (en) * 2010-02-17 2012-02-03 Ab7 Ind PROCESS FOR THE PREPARATION OF BIODEGRADABLE POLYMER GRANULES LOADED WITH ACTIVE LIPOPHILIC COMPOUNDS AND ACTIVE BIODEGRADABLE PRODUCTS OBTAINED
UA111162C2 (en) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. INJECTION COMPOSITION OF TRIAMCINOLONE ACETONIDE FOR TREATMENT OF PAIN
WO2012058138A1 (en) 2010-10-26 2012-05-03 Alcon Research, Ltd. Ophthalmoscopic surgical contact lens
WO2013019280A1 (en) * 2011-08-04 2013-02-07 Flexion Therapeutics Corticosteroids for the treatment of joint pain
JP2015532928A (en) * 2012-09-20 2015-11-16 アキナ， インク．Ａｋｉｎａ， Ｉｎｃ． Biodegradable microcapsules containing filler material

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256677A (en) * 1976-04-12 1981-03-17 Magnavox Government And Industrial Electronics Co. Apparatus and method for making small spheres
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
WO2004041251A1 (en) * 2002-11-04 2004-05-21 Ocean Nutrition Canada Limited Microcapsules having multiple shells and method for the preparation thereof
WO2005018794A1 (en) * 2003-08-22 2005-03-03 Danisco A/S Microcapsules

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920006865B1 (en) * 1984-05-18 1992-08-21 워싱톤 유니버시티 테크놀러지 어소우시에이츠 인코오퍼레이티드 Method and apparatus for coating particles or liquid droplets
US5643594A (en) * 1992-05-29 1997-07-01 The Regents Of The University Of California Spin encapsulation apparatus and method of use
SE505146C2 (en) * 1995-10-19 1997-06-30 Biogram Ab Particles for delayed release
EP1594511A2 (en) * 2003-02-20 2005-11-16 Alcon, Inc. Formulations of glucocorticoids to treat pathologic ocular angiogenesis
JP4487141B2 (en) * 2003-08-20 2010-06-23 参天製薬株式会社 Drug delivery system for microtenon subcapsular administration
CN102144961A (en) * 2003-09-18 2011-08-10 参天制药株式会社 Transscleral delivery
US8277831B2 (en) * 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256677A (en) * 1976-04-12 1981-03-17 Magnavox Government And Industrial Electronics Co. Apparatus and method for making small spheres
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
WO2004041251A1 (en) * 2002-11-04 2004-05-21 Ocean Nutrition Canada Limited Microcapsules having multiple shells and method for the preparation thereof
WO2005018794A1 (en) * 2003-08-22 2005-03-03 Danisco A/S Microcapsules

Also Published As

Publication number Publication date
BRPI0615563A2 (en) 2011-05-24
JP2009507845A (en) 2009-02-26
AU2006287499A1 (en) 2007-03-15
WO2007030545A2 (en) 2007-03-15
EP1931387A2 (en) 2008-06-18
KR20080059175A (en) 2008-06-26
CA2621395A1 (en) 2007-03-15
WO2007030545A3 (en) 2007-11-08

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Inventor name: ZWIENER, ALBERT, M.

Inventor name: SLOVIN, ELIOT, M.

Inventor name: VAIL, NEAL, K.

Inventor name: MCDONOUGH, JOSEPH, A.

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