EP1438567A4 - Methods and systems for microfluidic processing - Google Patents

Methods and systems for microfluidic processing

Info

Publication number
EP1438567A4
EP1438567A4 EP02715213A EP02715213A EP1438567A4 EP 1438567 A4 EP1438567 A4 EP 1438567A4 EP 02715213 A EP02715213 A EP 02715213A EP 02715213 A EP02715213 A EP 02715213A EP 1438567 A4 EP1438567 A4 EP 1438567A4
Authority
EP
European Patent Office
Prior art keywords
systems
methods
microfluidic processing
microfluidic
processing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02715213A
Other languages
German (de)
French (fr)
Other versions
EP1438567B1 (en
EP1438567A1 (en
Inventor
Gene Parunak
Kalyan Handique
Betty Wu
Karthik Ganesan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HandyLab Inc
Original Assignee
HandyLab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/014,519 external-priority patent/US7192557B2/en
Priority claimed from US10/014,520 external-priority patent/US7270786B2/en
Priority claimed from US10/075,371 external-priority patent/US7323140B2/en
Application filed by HandyLab Inc filed Critical HandyLab Inc
Priority to EP18185265.8A priority Critical patent/EP3427834A1/en
Publication of EP1438567A1 publication Critical patent/EP1438567A1/en
Publication of EP1438567A4 publication Critical patent/EP1438567A4/en
Application granted granted Critical
Publication of EP1438567B1 publication Critical patent/EP1438567B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
EP02715213.1A 2001-07-26 2002-03-27 Methods and systems for microfluidic processing Expired - Lifetime EP1438567B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18185265.8A EP3427834A1 (en) 2001-07-26 2002-03-27 Methods and systems for microfluidic processing

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US30763801P 2001-07-26 2001-07-26
US307638P 2001-07-26
US10/014,519 US7192557B2 (en) 2001-03-28 2001-12-14 Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US14520 2001-12-14
US14519 2001-12-14
US10/014,520 US7270786B2 (en) 2001-03-28 2001-12-14 Methods and systems for processing microfluidic samples of particle containing fluids
US10/075,371 US7323140B2 (en) 2001-03-28 2002-02-15 Moving microdroplets in a microfluidic device
US75371 2002-02-15
PCT/US2002/009440 WO2003012406A1 (en) 2001-07-26 2002-03-27 Methods and systems for microfluidic processing

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP18185265.8A Division EP3427834A1 (en) 2001-07-26 2002-03-27 Methods and systems for microfluidic processing

Publications (3)

Publication Number Publication Date
EP1438567A1 EP1438567A1 (en) 2004-07-21
EP1438567A4 true EP1438567A4 (en) 2010-06-02
EP1438567B1 EP1438567B1 (en) 2018-07-25

Family

ID=27486401

Family Applications (2)

Application Number Title Priority Date Filing Date
EP02715213.1A Expired - Lifetime EP1438567B1 (en) 2001-07-26 2002-03-27 Methods and systems for microfluidic processing
EP18185265.8A Withdrawn EP3427834A1 (en) 2001-07-26 2002-03-27 Methods and systems for microfluidic processing

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18185265.8A Withdrawn EP3427834A1 (en) 2001-07-26 2002-03-27 Methods and systems for microfluidic processing

Country Status (4)

Country Link
EP (2) EP1438567B1 (en)
JP (1) JP4596776B2 (en)
ES (1) ES2683698T3 (en)
WO (1) WO2003012406A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
EP2402089A1 (en) 2003-07-31 2012-01-04 Handylab, Inc. Processing particle-containing samples
US7665303B2 (en) 2004-03-31 2010-02-23 Lifescan Scotland, Ltd. Method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit
US7059352B2 (en) 2004-03-31 2006-06-13 Lifescan Scotland Triggerable passive valve for use in controlling the flow of fluid
US7156117B2 (en) 2004-03-31 2007-01-02 Lifescan Scotland Limited Method of controlling the movement of fluid through a microfluidic circuit using an array of triggerable passive valves
WO2005108620A2 (en) 2004-05-03 2005-11-17 Handylab, Inc. Processing polynucleotide-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2001990B1 (en) 2006-03-24 2016-06-29 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
EP3741869A1 (en) 2007-07-13 2020-11-25 Handylab, Inc. Polynucleotide capture materials and methods of using same
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
CA2833262C (en) 2011-04-15 2020-08-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
KR102121853B1 (en) 2011-09-30 2020-06-12 벡톤 디킨슨 앤드 컴퍼니 Unitized reagent strip
CN104040238B (en) 2011-11-04 2017-06-27 汉迪拉布公司 Polynucleotides sample preparation apparatus
CA2863637C (en) 2012-02-03 2021-10-26 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
WO2020112081A1 (en) * 2018-11-26 2020-06-04 Hewlett-Packard Development Company, L.P. Microfluidic devices
CN112023990B (en) * 2019-06-03 2023-06-23 利多(香港)有限公司 Microfluidic detection chip and manufacturing method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635358A (en) * 1992-05-01 1997-06-03 Trustees Of The University Of Pennsylvania Fluid handling methods for use in mesoscale analytical devices
WO1998022625A1 (en) * 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods
US5922591A (en) * 1995-06-29 1999-07-13 Affymetrix, Inc. Integrated nucleic acid diagnostic device

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US6130098A (en) * 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
JPH10108666A (en) * 1996-10-04 1998-04-28 Asahi Medical Co Ltd Hollow fiber type incubator
ES2279600T3 (en) * 1998-03-12 2007-08-16 Miltenyi Biotec Gmbh MICROCOLUMN SYSTEM FOR MAGNETIC SEPARATION.
JP4074713B2 (en) * 1998-07-29 2008-04-09 財団法人川村理化学研究所 Liquid feeding device and manufacturing method thereof
JP2000166535A (en) * 1998-12-10 2000-06-20 Nippon Laser Denshi Kk Divided microinjector
DE19948473A1 (en) * 1999-10-08 2001-04-12 Nmi Univ Tuebingen Method and device for measuring cells in a liquid environment
US6272939B1 (en) * 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635358A (en) * 1992-05-01 1997-06-03 Trustees Of The University Of Pennsylvania Fluid handling methods for use in mesoscale analytical devices
US5922591A (en) * 1995-06-29 1999-07-13 Affymetrix, Inc. Integrated nucleic acid diagnostic device
WO1998022625A1 (en) * 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HANDIQUE K ET AL: "ON-CHIP THERMOPNEUMATIC PRESSURE FOR DISCRETE DROP PUMPING", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US LNKD- DOI:10.1021/AC000711F, vol. 73, no. 8, 15 April 2001 (2001-04-15), pages 1831 - 1838, XP001030281, ISSN: 0003-2700 *
See also references of WO03012406A1 *

Also Published As

Publication number Publication date
EP3427834A1 (en) 2019-01-16
JP2005514718A (en) 2005-05-19
ES2683698T3 (en) 2018-09-27
EP1438567B1 (en) 2018-07-25
EP1438567A1 (en) 2004-07-21
WO2003012406A1 (en) 2003-02-13
WO2003012406A9 (en) 2003-03-20
JP4596776B2 (en) 2010-12-15

Similar Documents

Publication Publication Date Title
EP1438567A4 (en) Methods and systems for microfluidic processing
GB2397256B (en) Apparatus and methods for microfluidic applications
AU2003284055A8 (en) Microfluidic systems and components
EP1368909A4 (en) Location system and methods
EP1411757A4 (en) System and method for phytomonitoring
AU2002360239A1 (en) Fluid processing device and method
AU2002352831A1 (en) Methods and systems for analyzing complex biological systems
AU2002353053A1 (en) Modular systems and methods for using sample processing devices
AU2002308687A1 (en) Micromagnetic systems and methods for microfluidics
GB0414430D0 (en) Detection systems and methods
AU2002353107A8 (en) Microfluidic devices and methods for two-dimensional separations
AU7024801A (en) Enhanced sample processing devices, systems and methods
GB0412418D0 (en) Systems and methods for automated commission processing
IL159957A0 (en) Protein and nucleic expression systems
AU2003261299A8 (en) Systems and methods for processing benefits
GB0102245D0 (en) Systems/Methods
HK1048870A1 (en) Device environment configuration system and deviceenvironment configuration method
EP1690173A4 (en) Command processing systems and methods
EP1478228A4 (en) Anti-microbial systems and methods
GB2376073B (en) Fluid-gauging systems and methods
GB2396558B (en) Method and system for processing bio-contaminated articles
IL160392A0 (en) Vcd-on-demand system and method
SG104991A1 (en) Methods and systems for high throughput analysis
GB0203645D0 (en) System and process for analysis
AU2002247426A1 (en) Methods and systems for microfluidic processing

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040427

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

D17P Request for examination filed (deleted)
R17P Request for examination filed (corrected)

Effective date: 20040427

RIN1 Information on inventor provided before grant (corrected)

Inventor name: WU, BETTY

Inventor name: HANDIQUE, KALYAN

Inventor name: GANESAN, KARTHIK

Inventor name: PARUNAK, GENE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: HANDYLAB, INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20100503

17Q First examination report despatched

Effective date: 20120323

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: HANDYLAB, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 60249534

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: G01N0021290000

Ipc: B01L0003000000

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RIC1 Information provided on ipc code assigned before grant

Ipc: B01L 3/00 20060101AFI20180119BHEP

INTG Intention to grant announced

Effective date: 20180206

GRAJ Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

GRAR Information related to intention to grant a patent recorded

Free format text: ORIGINAL CODE: EPIDOSNIGR71

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

INTC Intention to grant announced (deleted)
AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

INTG Intention to grant announced

Effective date: 20180618

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1021175

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180815

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 60249534

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2683698

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20180927

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1021175

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180725

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180725

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181026

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180725

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180725

REG Reference to a national code

Ref country code: CH

Ref legal event code: PK

Free format text: BERICHTIGUNGEN

RIC2 Information provided on ipc code assigned after grant

Ipc: B01L 3/00 20060101AFI20180119BHEP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 60249534

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180725

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20190426

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180725

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190327

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20190331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190331

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190331

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190327

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180725

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181125

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20210219

Year of fee payment: 20

Ref country code: FR

Payment date: 20210218

Year of fee payment: 20

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180725

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20210219

Year of fee payment: 20

Ref country code: DE

Payment date: 20210217

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20210401

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20210217

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 60249534

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: MK

Effective date: 20220326

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20220326

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20220326

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20220902

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20220328