EP1427855A4 - Method and reagents for identifying gene targets for treating breast cancer - Google Patents

Method and reagents for identifying gene targets for treating breast cancer

Info

Publication number
EP1427855A4
EP1427855A4 EP02761122A EP02761122A EP1427855A4 EP 1427855 A4 EP1427855 A4 EP 1427855A4 EP 02761122 A EP02761122 A EP 02761122A EP 02761122 A EP02761122 A EP 02761122A EP 1427855 A4 EP1427855 A4 EP 1427855A4
Authority
EP
European Patent Office
Prior art keywords
reagents
breast cancer
treating breast
gene targets
identifying gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02761122A
Other languages
German (de)
French (fr)
Other versions
EP1427855A2 (en
Inventor
Thomas Primiano
Bey-Dih Chang
Igor B Roninson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois
Original Assignee
University of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois filed Critical University of Illinois
Publication of EP1427855A2 publication Critical patent/EP1427855A2/en
Publication of EP1427855A4 publication Critical patent/EP1427855A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
EP02761122A 2001-07-20 2002-07-19 Method and reagents for identifying gene targets for treating breast cancer Withdrawn EP1427855A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30673001P 2001-07-20 2001-07-20
US306730P 2001-07-20
WOPCT/US02/06254 2002-02-28
PCT/US2002/006254 WO2003008578A2 (en) 2001-07-20 2002-02-28 Reagents and methods for identifying gene targets for treating cancer
PCT/US2002/022868 WO2003007884A2 (en) 2001-07-20 2002-07-19 Method and reagents for identifying gene targets for treating breast cancer

Publications (2)

Publication Number Publication Date
EP1427855A2 EP1427855A2 (en) 2004-06-16
EP1427855A4 true EP1427855A4 (en) 2005-04-20

Family

ID=23186592

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02761122A Withdrawn EP1427855A4 (en) 2001-07-20 2002-07-19 Method and reagents for identifying gene targets for treating breast cancer

Country Status (6)

Country Link
US (2) US7235403B2 (en)
EP (1) EP1427855A4 (en)
JP (2) JP2005516586A (en)
AU (1) AU2002326409B2 (en)
CA (1) CA2454423A1 (en)
WO (2) WO2003008578A2 (en)

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Publication number Priority date Publication date Assignee Title
US7098192B2 (en) 1999-04-08 2006-08-29 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of STAT3 expression
US20040110701A1 (en) * 2002-12-10 2004-06-10 Isis Pharmaceuticals Inc. Modulation of zinedin expression
EP1668155A2 (en) * 2003-09-24 2006-06-14 Oncotherapy Science, Inc. Methods for detecting, diagnosing and treating hepatocellular carcinomas (hcc)
EP2363480A3 (en) * 2004-01-20 2015-10-07 Isis Pharmaceuticals, Inc. Modulation of glucocorticoid receptor expression
US20070269378A1 (en) * 2004-06-18 2007-11-22 Exelixis Inc. Nadks as Modifiers of Branching Morphogenesis and Methods of Use
WO2006094029A2 (en) * 2005-02-28 2006-09-08 Kosan Biosciences Incoporated Pharmaceutical formulations containing 17-allylamino-17-demethoxygeldanamycin
US8076061B2 (en) 2007-09-07 2011-12-13 Ascentgene, Inc. Method and composition for cancer diagnosis and treatment
CN102323247A (en) * 2008-09-07 2012-01-18 苏州爱生基因有限公司 Method for screening drug for treating or preventing cancer
CN102274490A (en) * 2008-09-07 2011-12-14 苏州爱生基因有限公司 Medicament for treating or preventing cancer
CN102274489A (en) * 2008-09-07 2011-12-14 苏州爱生基因有限公司 Medicine for treating and preventing cancers
US20120252028A1 (en) 2009-08-14 2012-10-04 Michael Shtulman Target genes for cancer therapy
KR102050469B1 (en) 2011-04-01 2019-12-02 아이오니스 파마수티컬즈, 인코포레이티드 Modulation of signal transducer and activator of transcription 3 (stat3) expression
CN103906838A (en) 2011-10-25 2014-07-02 Isis制药公司 Antisense modulation of GCCR expression

Citations (5)

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Publication number Priority date Publication date Assignee Title
EP0881300A2 (en) * 1997-05-30 1998-12-02 Cell Pathways, Inc. Method for identifying compounds for inhibition of neoplastic lesions
US5998136A (en) * 1996-08-19 1999-12-07 Arcaris, Inc. Selection systems and methods for identifying genes and gene products involved in cell proliferation
WO2000055174A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human prostate cancer associated gene sequences and polypeptides
WO2001023617A1 (en) * 1999-09-30 2001-04-05 National Jewish Medical And Research Center Method for regulating cell growth and assays related thereto
WO2001040464A1 (en) * 1999-11-30 2001-06-07 Genentech, Inc. Interleukin-1-receptor associated kinase-3 (irak3) and its use in promotion or inhibition of angiogenesis and cardiovascularization

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US566550A (en) * 1896-08-25 James timms
US5512660A (en) * 1987-05-04 1996-04-30 Dana Farber Cancer Institute, Inc. Purified ICAM-2 and fragment thereof
US5849536A (en) * 1990-03-02 1998-12-15 Bio-Technology General Corp. Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same
US5942389A (en) 1990-10-19 1999-08-24 Board Of Trustees Of The University Of Illinois Genes and genetic elements associated with sensitivity to cisplatin
US5753432A (en) 1990-10-19 1998-05-19 Board Of Trustees Of The University Of Illinois Genes and genetic elements associated with control of neoplastic transformation in mammalian cells
US5866327A (en) 1990-10-19 1999-02-02 Board Of Trustees Of The University Of Illinois Association of kinensin with sensitivity to chemotherapeutic drugs
US6326488B1 (en) 1990-10-19 2001-12-04 Board Of Trustees Of University Of Illinois Gene and genetic elements associated with sensitivity to chemotherapeutic drugs
US5665550A (en) 1990-10-19 1997-09-09 Board Of Trustees Of The University Of Illinois-Urbana Genes and genetic elements associated with sensitivity to chemotherapeutic drugs
US5217889A (en) 1990-10-19 1993-06-08 Roninson Igor B Methods and applications for efficient genetic suppressor elements
US6268134B1 (en) 1993-09-07 2001-07-31 Board Of Trustees Of University Of Il Method and applications for efficient genetic suppressor elements
US5969124A (en) * 1992-06-26 1999-10-19 Case Western Reserve University Nucleotide sequence of L1CAM
FR2703693B1 (en) 1993-04-06 1995-07-13 Pasteur Institut Rapid method of determining a DNA sequence and application to sequencing and diagnosis.
US5654168A (en) 1994-07-01 1997-08-05 Basf Aktiengesellschaft Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units
IL110787A0 (en) * 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
US5851796A (en) 1995-06-07 1998-12-22 Yale University Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes
US5968773A (en) 1997-11-14 1999-10-19 Heddle; John A. System and method for regulation of gene expression
US6060134A (en) 1998-05-22 2000-05-09 Flaura Technologies, Llc Method of preserving botanical specimens
US6706491B1 (en) 1999-04-09 2004-03-16 The Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by p21

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998136A (en) * 1996-08-19 1999-12-07 Arcaris, Inc. Selection systems and methods for identifying genes and gene products involved in cell proliferation
EP0881300A2 (en) * 1997-05-30 1998-12-02 Cell Pathways, Inc. Method for identifying compounds for inhibition of neoplastic lesions
WO2000055174A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human prostate cancer associated gene sequences and polypeptides
WO2001023617A1 (en) * 1999-09-30 2001-04-05 National Jewish Medical And Research Center Method for regulating cell growth and assays related thereto
WO2001040464A1 (en) * 1999-11-30 2001-06-07 Genentech, Inc. Interleukin-1-receptor associated kinase-3 (irak3) and its use in promotion or inhibition of angiogenesis and cardiovascularization

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TALUKDER AMJAD H ET AL: "Heregulin induces expression, DNA binding activity, and transactivating functions of basic leucine zipper activating transcription factor 4", CANCER RESEARCH, vol. 60, no. 2, 15 January 2000 (2000-01-15), pages 276 - 281, XP002302778, ISSN: 0008-5472 *
UENO N T ET AL: "GROWTH SUPPRESSION OF LOW HER-2/NEU-EXPRESSING BREAST CANCER CELL LINE MDA-MB-435 BY TYROSINE KINASE INHIBITOR EMODIN", ONCOLOGY REPORTS, NATIONAL HELLENIC RESEARCH FOUNDATION, ATHENS, GR, vol. 3, no. 3, 1 May 1996 (1996-05-01), pages 509 - 511, XP000672384, ISSN: 1021-335X *

Also Published As

Publication number Publication date
CA2454423A1 (en) 2003-01-30
EP1427855A2 (en) 2004-06-16
AU2002326409B2 (en) 2007-02-15
WO2003007884A2 (en) 2003-01-30
JP2005516586A (en) 2005-06-09
WO2003007884A3 (en) 2003-11-20
WO2003008578A3 (en) 2003-07-31
US20070154933A1 (en) 2007-07-05
US20030180739A1 (en) 2003-09-25
JP2005514910A (en) 2005-05-26
WO2003008578A2 (en) 2003-01-30
US7235403B2 (en) 2007-06-26

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