EP1414499A4 - Non-invasive tumor imaging by tumor-targeted bacteria - Google Patents

Non-invasive tumor imaging by tumor-targeted bacteria

Info

Publication number
EP1414499A4
EP1414499A4 EP00970577A EP00970577A EP1414499A4 EP 1414499 A4 EP1414499 A4 EP 1414499A4 EP 00970577 A EP00970577 A EP 00970577A EP 00970577 A EP00970577 A EP 00970577A EP 1414499 A4 EP1414499 A4 EP 1414499A4
Authority
EP
European Patent Office
Prior art keywords
tumor
targeted bacteria
invasive
imaging
tumor imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00970577A
Other languages
German (de)
French (fr)
Other versions
EP1414499A2 (en
Inventor
David G Bermudes
Ivan Cheung-Lam King
Ronald G Blasberg
Juri G Tjuvajev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sloan Kettering Institute for Cancer Research
Vion Pharmaceuticals Inc
Original Assignee
Sloan Kettering Institute for Cancer Research
Vion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research, Vion Pharmaceuticals Inc filed Critical Sloan Kettering Institute for Cancer Research
Publication of EP1414499A4 publication Critical patent/EP1414499A4/en
Publication of EP1414499A2 publication Critical patent/EP1414499A2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
    • A61K49/0047—Green fluorescent protein [GFP]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP00970577A 1999-10-04 2000-10-04 Non-invasive tumor imaging by tumor-targeted bacteria Withdrawn EP1414499A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15762099P 1999-10-04 1999-10-04
US157620P 1999-10-04
PCT/US2000/027397 WO2001025399A2 (en) 1999-10-04 2000-10-04 Non-invasive tumor imaging by tumor-targeted bacteria

Publications (2)

Publication Number Publication Date
EP1414499A4 true EP1414499A4 (en) 2004-05-06
EP1414499A2 EP1414499A2 (en) 2004-05-06

Family

ID=22564528

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00970577A Withdrawn EP1414499A2 (en) 1999-10-04 2000-10-04 Non-invasive tumor imaging by tumor-targeted bacteria

Country Status (4)

Country Link
EP (1) EP1414499A2 (en)
AU (1) AU7993600A (en)
CA (1) CA2386806A1 (en)
WO (1) WO2001025399A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1738649A (en) * 2001-07-09 2006-02-22 抗癌公司 Imaging infection using fluorescent protein as a marker
EP1281767A3 (en) * 2001-07-31 2003-05-28 Aladar A. Szalay Light emitting microorganisms and cells for diagnosis and therapy of tumors
EP1281772A1 (en) * 2001-07-31 2003-02-05 Aladar A. Szalay Light-emitting microorganisms and cells for tumour diagnosis/therapy
EP1914316B1 (en) * 2001-08-01 2009-12-16 Genelux Corporation LIVP strain of vaccinia virus for diagnosis and therapy of tumours
CN1304559C (en) * 2001-10-09 2007-03-14 杭州康科生物技术有限公司 Oncolytic microorganism expressing heat shock protein and its application
JP4350519B2 (en) * 2001-12-31 2009-10-21 アンチキャンサー インコーポレーテッド System for monitoring tumor treatment with bacteria
EP1369491A1 (en) * 2002-06-05 2003-12-10 Aladar A. Szalay Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
JP4634710B2 (en) * 2002-07-31 2011-02-16 ゲネルクス コーポレーション Microorganisms and cells for tumor diagnosis and treatment
AU2004204751A1 (en) 2003-01-09 2004-07-29 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector
ATE420160T1 (en) 2003-06-18 2009-01-15 Genelux Corp MODIFIED RECOMBINANT VACCINIA VIRUSES, USES THEREOF
US8822194B2 (en) * 2004-06-29 2014-09-02 Anticancer, Inc. Cancer selective auxotrophs
EP1968648B1 (en) 2005-12-16 2015-05-06 Catherine M Shachaf Diagnostic system for the detection and diagnosis of skin cancer
EP2242516A1 (en) * 2008-01-11 2010-10-27 Genelux Corporation Methods and compositions for detection of bacteria and treatment of diseases and disorders
WO2012112317A1 (en) * 2011-02-15 2012-08-23 Albert Einstein College Of Medicine Of Yeshiva University Radiobacteria for therapy of cancer
US11268958B2 (en) * 2012-09-14 2022-03-08 The Johns Hopkins University Bacteria-specific labeled substrtates as imaging biomarkers to diagnose, locate, and monitor infections
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11168326B2 (en) 2017-07-11 2021-11-09 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
CN112673092B (en) 2018-07-11 2024-03-29 阿克蒂姆治疗有限公司 Engineered immunostimulatory bacterial strains and uses thereof
WO2020047161A2 (en) 2018-08-28 2020-03-05 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
KR102110993B1 (en) * 2018-12-20 2020-05-14 한국생명공학연구원 Composition for diagnosing, preventing or treating cancer comprising Klebsiella aerogenes as active ingredient
CA3131017A1 (en) 2019-02-27 2020-09-03 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
CA3161450A1 (en) 2019-11-12 2021-05-20 Actym Therapeutics, Inc. Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products
EP4196139A2 (en) 2020-08-12 2023-06-21 Actym Therapeutics, Inc. Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms
WO2023086796A2 (en) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005026A1 (en) * 1986-02-24 1987-08-27 The Trustees Of Columbia University In The City Of Dna encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof
US4863713A (en) * 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
US5631236A (en) * 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8318575D0 (en) * 1983-07-08 1983-08-10 Cobbold S P Antibody preparations
US5703056A (en) * 1995-03-15 1997-12-30 Sloan-Kettering Institute For Cancer Research Non-invasive imaging of gene transfer
US5681745A (en) * 1995-05-01 1997-10-28 Trustees Of Boston University Biotin-binding containment systems
US6190657B1 (en) * 1995-06-07 2001-02-20 Yale University Vectors for the diagnosis and treatment of solid tumors including melanoma
US5824538A (en) * 1995-09-06 1998-10-20 The United States Of America As Represented By The Secretary Of The Army Shigella vector for delivering DNA to a mammalian cell
US5997881A (en) * 1995-11-22 1999-12-07 University Of Maryland, Baltimore Method of making non-pyrogenic lipopolysaccharide or A
CN1253551C (en) * 1997-09-10 2006-04-26 维昂药品公司 Genetically modified tumor-targeted bacteria with reduced virulence

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005026A1 (en) * 1986-02-24 1987-08-27 The Trustees Of Columbia University In The City Of Dna encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof
US4863713A (en) * 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
US5631236A (en) * 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CARMICHAEL E ET AL: "In vivo expression of functional cytosine deaminase utilizing a tumor-targeted bacterial vector", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 38, no. 0, 1997, Eighty-eighth Annual Meeting of the American Association for Cancer Research;San Diego, California, USA; April 12-16, 1997, 1997, pages 7, XP001156445, ISSN: 0197-016X *
CURTISS R ET AL: "RECOMBINANT AVIRULENT SALMONELLA VACCINE STRAINS WITH STABLE MAINTENANCE AND HIGH LEVEL EXPRESSION OF CLONED GENES IN VIVO", IMMUNOLOGICAL INVESTIGATIONS, MARCEL DEKKER, NEW YORK, NY, US, vol. 18, no. 1-4, 1989, pages 583 - 596, XP009014132, ISSN: 0882-0139 *
GALLIZIA A ET AL: "PRODUCTION OF A SOLUBLE AND FUNCTIONAL RECOMBINANT STREPTAVIDIN IN ESCHERICHIA COLI", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, US, vol. 14, no. 2, November 1998 (1998-11-01), pages 192 - 196, XP000952523, ISSN: 1046-5928 *
KOPS S K ET AL: "Salmonella typhimurium as an anti-cancer vector: Localization within solid tumors", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 38, no. 0, 1997, Eighty-eighth Annual Meeting of the American Association for Cancer Research;San Diego, California, USA; April 12-16, 1997, 1997, pages 7, XP001156444, ISSN: 0197-016X *
LAMBIN P ET AL: "Anaerobic bacteria as a potential tumour gene transfer system", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 33, September 1997 (1997-09-01), pages S220, XP004283842, ISSN: 0959-8049 *
LOW K B ET AL: "LIPID A MUTANT SALMONELLA WITH SUPPRESSED VIRULENCE AND TNFALPHA INDUCTION RETAIN TUMOR-TARGETING IN VIVO", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, January 1999 (1999-01-01), pages 37 - 41, XP002939098, ISSN: 1087-0156 *
PAWELEK J M ET AL: "TUMOR-TARGETED SALMONELLA AS A NOVEL ANTICANCER VECTOR", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 57, October 1997 (1997-10-01), pages 4537 - 4544, XP002939099, ISSN: 0008-5472 *
See also references of WO0125399A3 *
TJUVAJEV J G ET AL: "IMAGING HERPES VIRUS THYMIDINE KINASE GENE TRANSFER AND EXPRESSION BY POSITRON EMISSION TOMOGRAPHY", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 58, no. 19, 1 October 1998 (1998-10-01), pages 4333 - 4341, XP001073448, ISSN: 0008-5472 *
WATSON W S: "Targeted Salmonella--a new way to image tumours?", NUCLEAR MEDICINE COMMUNICATIONS. ENGLAND OCT 1998, vol. 19, no. 10, October 1998 (1998-10-01), pages 1019, XP009021973, ISSN: 0143-3636 *

Also Published As

Publication number Publication date
AU7993600A (en) 2001-05-10
CA2386806A1 (en) 2001-04-12
EP1414499A2 (en) 2004-05-06
WO2001025399A2 (en) 2001-04-12
WO2001025399A3 (en) 2001-08-23

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