EP1412490A1 - Mediating the effects of alcohol consumption by orally administering active dry yeast - Google Patents
Mediating the effects of alcohol consumption by orally administering active dry yeastInfo
- Publication number
- EP1412490A1 EP1412490A1 EP01952631A EP01952631A EP1412490A1 EP 1412490 A1 EP1412490 A1 EP 1412490A1 EP 01952631 A EP01952631 A EP 01952631A EP 01952631 A EP01952631 A EP 01952631A EP 1412490 A1 EP1412490 A1 EP 1412490A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- alcohol
- yeast
- active dry
- blood
- dry yeast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Definitions
- the present invention relates to a process for lowering of blood alcohol (i.e. ethyl alcohol) levels in humans after they imbibe alcoholic beverages such as beer, wine or distilled spirits.
- alcoholic beverages such as beer, wine or distilled spirits.
- Consumption of alcoholic beverages in moderate amounts is an accepted societal practice. Additionally, consumption of alcoholic beverages in moderate amounts is considered to provide some health benefits in terms of reduced stress and incidence of heart attack. Consumption of alcoholic beverages in moderate amounts also is considered by many people to enhance the flavor and enjoyment of food. However, even moderate social drinkers can be affected by alcohol.
- Ethyl alcohol (CH 3 CH2OH) is a major purpose for the consumption of alcoholic beverages. When such beverages are consumed, the alcohol enters the stomach and is soon transported to the small intestine.
- the alcohol enters the blood stream via the portal vein and goes to the liver.
- a portion of the alcohol is oxidized to acetaldehyde by the enzyme alcohol dehydrogenase.
- the unoxidized alcohol goes to every part of the body through the general circulation.
- This alcohol which has free access to every cell in the body, exerts an influence on the central nervous system and the brain. These effects are well known. Operation of a motor vehicle is considered illegal if the level of alcohol in the blood (blood alcohol level) is above 0.1% (in some states) or 0.08% (in other states). Because alcohol diffuses into every cell in the body freely, the blood alcohol level may be measured in the breath as well as in the blood.
- the acetaldehyde produced is further oxidized almost instantaneously to acetate which enters the pathways of general metabolism. Acetaldehyde and acetate have no effect on the nervous system or the brain. Continued circulation through the liver eventually removes all the alcohol.
- the enzyme alcohol dehydrogenase requires a coenzyme called nicotinamide adenine dinucleotide (NAD) in order to catalyze the conversion of ethanol to acetaldehyde.
- NAD nicotinamide adenine dinucleotide
- U.S. Patent 4,450,153 to Hopkins proposes a process for reducing the effects of alcohol consumption by reducing the alcohol content in human blood by the administration of alcohol oxidase.
- alcohol oxidase may be administered by direct injection into the human body, or by direct contact with the blood by means of dialysis.
- Hopkins also suggests that alcohol oxidase may be administered orally; however, Hopkins needs his alcohol oxidase to be enteric coated to protect it from being destroyed in the stomach. He does not reduce alcohol levels in the stomach. He actively avoids this. It is therefore an object of the present invention to provide a process for the reduction of human blood alcohol level by attacking alcohol only in the stomach.
- blood alcohol level is lowered by the oral administration of an extraneous source of the enzyme alcohol dehydrogenase before or concomitantly with the drinking of the alcoholic beverage.
- the alcohol dehydrogenase may be consumed as the purified enzyme, or more conveniently, by the ingestion of a natural source of the enzyme, such as active dry bakers, brewers, vintners or distillers yeast.
- active bakers, vintners and distillers yeast comprise Saccharomyces c ⁇ revisiae
- active brewers yeast comprises Saccharomyces uvarum.
- yeasts may be delivered in powdered, paste or liquid form, i.e. suspended in a liquid, but most conveniently are packaged in dose or portion controlled dried form as a tablet or caplet, or in capsule form. It has been found that ingesting active dry bakers yeast (the yeast most readily available commercially) or brewers, vintners or distillers yeast, just before, or during, the drinking of an alcoholic beverage, oxidizes a portion of the alcohol while still in the stomach, which results in a lower peak blood alcohol level, and also a lesser area under the curve of a plot of blood alcohol level vs. time.
- Fig s - 1-8 are plots showing reduction of blood alcohol levels over time with several alcoholic beverages, with and without the ingestion of alcohol dehydrogenase from active dry yeast. As noted supra, when an alcohoHc beverage is consumed, the alcohol enters the stomach and is soon transported to the small intestine.
- the speed of egress from the stomach is delayed by the presence of food or fats in the stomach, and by the dilution and buffering capacity of the alcoholic liquid.
- the speed of the egress from the stomach is quickened by high concentration of the alcohoHc drink and by carbon dioxide in the drink.
- the alcohol is absorbed into the blood stream via the portal vein and goes to the Hver.
- a portion of the alcohol while still in the stomach is oxidized to acetaldehyde by the ingestion of an extraneous source of the enzyme alcohol dehydrogenase.
- Alcohol dehydrogenase in accordance with the present invention may be before or concomitantly with the consumption of the alcohoHc beverage. Continued drinking requires the periodic ingestion of additional alcohol dehydrogenase during the drinking period.
- the amount of alcohol dehydrogenase which should be ingested to reduce the blood alcohol level to an acceptable level depends on several factors: the weight of the individual; the sex of the individual; the amount of alcohol consumed; the rate of alcohol consumption; the general health and age of the individual; and the presence of food in the stomach.
- the alcohol dehydrogenase is ingested in the amount of 0.5 to 10 grams of active dry bakers, brewers, distillers .or vintners yeast.
- the amount needed is determined by the six factors Hsted above, and the idiosyncratic behavior of different people to alcohol. While the alcohol dehydrogenase may be ingested, for example, as a suspension in a Hquid or paste, the most convenient and effective way to administer the alcohol dehydrogenase is by means of dose controlled tablets, capsules or caplets containing active dry bakers, brewers, vintners or distillers yeast. The advantage of ingesting the alcohol dehydrogenase in this manner is that it permits the drinker to self-dose during the imbibition period.
- Example I Eighty-eight milHHters of 80 proof vodka, diluted with 80 ml. of water are consumed by a young, 160 pound (72.6 kg.) adult woman, within 5 minutes.
- the alcohol content in the breath is measured periodically until the level falls below 0.002% .
- the experiment is repeated, with the same woman, but this time, 2.5 g. of active dry bakers yeast is ingested followed by 88 ml. of 80 proof vodka diluted with 80 ml of water.
- the alcohol content in the breath is measured periodicaUy.
- the results for both tests are shown in Fig. 1 and show the decrease in blood alcohol level caused by the yeast.
- the decrease, as measured by the areas under the curves in blood alcohol level - min. was 29% .
- Example II The same tests, without and with the ingestion of 2.5 g. of active dry bakers yeast were done. This time the tests were run with a young, 155 pound (70.3 kg.) adult man. The results for both tests are shown in Fig. 2. The decrease in blood alcohol level when the yeast was taken is clearly shown, and quantitatively demonstrated by the reduction in blood alcohol level-min. of 23% in the areas under the curves.
- Example III A mature 170 pound (77.1 kg.) adult man consumed 268 ml. of chardonnay wine, 13% alcohol by volume in 11 minutes. His blood alcohol level was measured periodicaUy. The test was repeated, by the same man, but this time 2.5 g. of active dry vintners yeast was ingested just before the wine was consumed.
- Example IV A mature, 170 pound (77.1 kg.) woman performed the same tests as in Example III. The results are plotted in Fig. 4. The areas under the curve, in blood alcohol level-min., decreased by 21% when the yeast was taken just before the wine was consumed.
- Example V Seven hundred and ten ml. (24 oz.) of a standard American beer (5% alcohol by volume) was consumed by a mature, 150 pound (68 kg.) adult woman in 13 minutes, and then the blood alcohol level was measured periodicaUy. The same woman ate 5.0 g.
- Example VI Twenty-four ounces of a standard American beer, the same as in Example V, was consumed by a mature, 140 pound (63.4 kg.) adult man in 8 minutes. His blood alcohol level was measured periodicaUy. The same amount of the same beer was consumed by the same man, except 2.5 g. of active dry bakers yeast was taken at the start of the beer drinking, which was finished in 14 minutes. Blood alcohol levels were measured periodically. The results of both tests are shown in Fig. 6.
- Example VII Twenty-four ounces of a light beer, alcohol content 4.2% by volume, was consumed by a mature, 150 pound (68 kg.) adult woman, after 3.0 g. of active dry brewers yeast was ingested, all in 15 min. The blood alcohol level was measured periodicaUy. The same amount of the same beer was consumed by the same woman, but without any yeast. The results of both tests, are shown in Fig. 7. The area under the curve, in blood alcohol level-min. was reduced by 38% by the yeast.
- Example VIII A mature, 155 pound (70.3 kg.) adult man consumed 24 oz. of the same beer as in Example VII, right with the ingestion of 1.5 g.
Abstract
Description
Claims
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2001/021870 WO2003006642A1 (en) | 2000-02-25 | 2001-07-11 | Mediating the effects of alcohol consumption by orally administering active dry yeast |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1412490A1 true EP1412490A1 (en) | 2004-04-28 |
EP1412490A4 EP1412490A4 (en) | 2005-02-09 |
Family
ID=32067645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01952631A Withdrawn EP1412490A4 (en) | 2001-07-11 | 2001-07-11 | Mediating the effects of alcohol consumption by orally administering active dry yeast |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1412490A4 (en) |
JP (1) | JP2004536852A (en) |
AU (1) | AU2001273364B2 (en) |
CA (1) | CA2452476A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015008101A1 (en) | 2013-07-15 | 2015-01-22 | Schaumlöffel Rolf A | Composition of a drink for enhanced reduction of blood alcohol level |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4450153A (en) * | 1982-09-30 | 1984-05-22 | Phillips Petroleum Company | Alcohol removal from blood with alcohol oxidase |
WO1996039174A1 (en) * | 1995-06-06 | 1996-12-12 | The University Of Georgia Research Foundation, Inc. | Method for rapid enzymatic alcohol removal |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4006219A (en) * | 1972-08-10 | 1977-02-01 | Ceres Pharmacal Company | Composition and method for countering effects of alcohol consumption |
US3954979A (en) * | 1972-11-24 | 1976-05-04 | Ceres Products Company, Inc. | Process for preparing stabilized yeast and compositions and tableting composition and method |
-
2001
- 2001-07-11 EP EP01952631A patent/EP1412490A4/en not_active Withdrawn
- 2001-07-11 CA CA002452476A patent/CA2452476A1/en not_active Abandoned
- 2001-07-11 JP JP2003512400A patent/JP2004536852A/en not_active Abandoned
- 2001-07-11 AU AU2001273364A patent/AU2001273364B2/en not_active Ceased
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4450153A (en) * | 1982-09-30 | 1984-05-22 | Phillips Petroleum Company | Alcohol removal from blood with alcohol oxidase |
WO1996039174A1 (en) * | 1995-06-06 | 1996-12-12 | The University Of Georgia Research Foundation, Inc. | Method for rapid enzymatic alcohol removal |
Non-Patent Citations (1)
Title |
---|
See also references of WO03006642A1 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015008101A1 (en) | 2013-07-15 | 2015-01-22 | Schaumlöffel Rolf A | Composition of a drink for enhanced reduction of blood alcohol level |
Also Published As
Publication number | Publication date |
---|---|
JP2004536852A (en) | 2004-12-09 |
AU2001273364B2 (en) | 2006-12-07 |
EP1412490A4 (en) | 2005-02-09 |
AU2001273364A2 (en) | 2003-01-29 |
CA2452476A1 (en) | 2003-01-23 |
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Legal Events
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17P | Request for examination filed |
Effective date: 20040119 |
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AX | Request for extension of the european patent |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20041228 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 35/72 B Ipc: 7A 61K 38/44 B Ipc: 7C 12N 1/18 B Ipc: 7C 12N 1/16 B Ipc: 7C 12N 9/06 A |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 07H 21/04 B Ipc: 7C 12P 19/34 B Ipc: 7C 12Q 1/68 A |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 01N 63/04 B Ipc: 7A 61K 38/44 B Ipc: 7C 12N 1/18 B Ipc: 7C 12N 1/16 B Ipc: 7C 12N 9/06 A |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20050330 |