EP1408861A2 - Applicator for the application of cryogenic refrigerants and application device - Google Patents
Applicator for the application of cryogenic refrigerants and application deviceInfo
- Publication number
- EP1408861A2 EP1408861A2 EP00993305A EP00993305A EP1408861A2 EP 1408861 A2 EP1408861 A2 EP 1408861A2 EP 00993305 A EP00993305 A EP 00993305A EP 00993305 A EP00993305 A EP 00993305A EP 1408861 A2 EP1408861 A2 EP 1408861A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- applicator according
- channel
- application
- diameter
- applicator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B18/0218—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques with open-end cryogenic probe, e.g. for spraying fluid directly on tissue or via a tissue-contacting porous tip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K5/00—Heat-transfer, heat-exchange or heat-storage materials, e.g. refrigerants; Materials for the production of heat or cold by chemical reactions other than by combustion
- C09K5/08—Materials not undergoing a change of physical state when used
- C09K5/10—Liquid materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
Definitions
- the invention relates to an applicator for the application of cryogenic cooling media according to the preamble of claim 1 and an application device.
- the criterion should be met that the coolant consumption should be as low as possible, that is, that it should correspond to the actual cooling requirement as far as possible without evaporation losses that do not contribute to the desired cooling capacity, and on the other hand, one should be spatially exactly defined point can be cooled, which is defined as sharply as possible from its periphery.
- it is known, for example, to use cold for therapeutic effects, tissue destruction or pathological skin reaction, which are desired and used successfully in certain indications. So far, devices have been used for this, which either allow contact-freezing or spray-gas-freezing.
- Liquid-freezing is also known, in which liquid nitrogen is absorbed with a cotton swab and applied to the surface or skin to be treated.
- liquid-freezing with liquid nitrogen represents the ideal form of introducing cold, since this is where the greatest cooling capacity is achieved; however, selective application of the cooling medium is not possible, so that healthy peripheral tissue is also cooled with this method, whereby healthy tissue is used in medical applications. burns and when using other coolants that have a higher boiling point, such a good cooling performance is not achieved.
- an application capillary which applies the cryogenic cooling liquid precisely to the area to be cooled. Furthermore, an application device is provided which is equipped with the application capillary according to the invention.
- cryogenic coolants such as liquid nitrogen, liquid argon, CO 2 or N 2 0, precisely and with the amount corresponding to the theoretical coolant requirement. Even when using cryogenic coolants with relatively high evaporation temperatures, high freezing speeds of LOOK / min are ensured.
- the cryogenic cooling liquids can be brought to the location to be cooled in a single liquid phase without the formation of bubbles and the associated evaporation losses.
- an appli- cation capillary with a diameter adapted to the pressure of the gas has particularly good application properties.
- a preferred pressure is about 50 bar.
- the pressure is 55 bar.
- An application capillary used to apply N 2 O has particularly good application properties at a diameter of 30-40 ⁇ m at the exit point.
- the preferred diameter is 25-30 ⁇ m.
- the application capillary according to the invention is preferably supplied with the cryogenic coolant by means of a hand-held device.
- FIG. 1 An application capillary according to the invention
- Fig. 2 Another embodiment of the application capillary from Fig. 1
- Fig. 3 A similar embodiment as in Fig. 2
- Fig. 4 Another embodiment of the application capillary according to the invention
- Fig. 5 A hand-held device which is equipped with an application capillary according to the invention.
- FIG. 6 A closure for the application capillary according to the invention 7: Components of a further hand-held device provided with an application capillary according to the invention.
- the embodiment of the application capillary 1 shown in FIG. 1 preferably has an outer diameter of at most 1 mm and leads a channel 2 to a nozzle 3 which has a tip 4. Between the tip 4 and the channel 2 there is a narrowing 5 of the outer radius of the application capillary 1 channel 2, which maintain a distance from the tip 4, so that a cavity 6 is created which allows cryogenic liquid to escape.
- the channel 2 continues between the application capillary 1 and the tip 4 and there has at least one opening 7 through which the cryogenic coolant exits.
- Figure 2 shows a modified representation of the nozzle of Figure 1 in a cross section.
- reference numerals 1 and 2 again mean the application capillary and a channel, as in FIG. 1, the narrowing of the outer diameter of the application capillary 1 between the channel 2 and the tip 4.
- the nozzle 3 is the distance ensures between the channel 2 and the tip 4, not connected in one piece to the application capillary 1, but consists of a separate body which is inserted at the end of the application capillary 1 in the channel 2 and with the inner wall of the channel 2, for example by welding, connected is .
- the inside diameter of channel 2 is 0.1 to 1 mm, preferably about 0.5 mm, while the inner diameter of the nozzle 3 has a diameter of 30 to 40 microns.
- the outside diameter of the application capillary 1 is preferably less than 1 mm, while the outside diameter of the channel 9 is preferably 0.5 mm.
- the channel 9 has at least two nozzle openings 10, 10 'on two sides which have a diameter of 30 to 40 ⁇ m. At the lower end of the nozzle 3 is the tip 4, which on the side facing the nozzle 3 has a step 11 with the same diameter as the application capillary 1.
- the stage 11 forms, together with the nozzle 3 and the end of the application capillary 1, a cavity 6 which can receive an evaporating liquid which emerges from the nozzle 3 with the openings 10 and 10 'and evaporates there in contact with the surface to be cooled.
- the nozzle 3 can be protected with a sealing cap, which is not shown in FIG. 2 and which can simultaneously take on the function of a valve.
- FIG. 3 Another variant of the embodiment in FIG. 2 is shown in FIG. 3. Similar to FIG. 2, the nozzle body 5 is not manufactured in an integrated manner with the application capillary 1, but rather is also formed as a separate piece which is introduced into the channel 2 and is connected to a coolant source (not shown in the drawing).
- the coolant source can include N 2 0, Ar or another cryogenic liquid gas, such as liquid nitrogen or liquid CO 2 .
- the nozzle body 5 is incorporated into the channel 2 and forms a channel 12 with the inner wall of the channel 2, which has an inner diameter of 30 to 40 ⁇ m.
- the channel 2 has an inner diameter of 1-0.1 mm, preferably an inner diameter of 0.5 mm.
- the channel 12 opens into a nozzle opening 13 and, via its extension 14, leads to the nozzle opening 13 'on the side opposite the nozzle opening 13. put side.
- the channel 12 and the two nozzle openings 13 and 13 ' have a preferred diameter of 30 to 40 microns.
- the end sections of the application capillary 1, the step 11 of the tip 4, and the nozzle body 5 together form a cavity 6, 6 'in which the cryogenic liquid can pass into the gas phase. At this point, pressure relief occurs. This creates a two-phase mixture.
- the embodiment of the application capillary 1 shown in FIG. 4 comprises a microcapillary 15, thermal insulation 16 and a microfilter 17 which is fixed by an upper and lower O-ring 18, 19.
- the microcapillary 15 consists of a metal jacket 20 with an upper and lower end 21, 22.
- the metal jacket 20 preferably includes an inner surface with a layer of plastic 23, which includes a channel 24.
- the lower end 22 of the metal casing 20 forms a dome-shaped bottom which has a bore 25 with a diameter of approximately 30 to 40 ⁇ m, particularly preferably 33 to 37 ⁇ m.
- the bore 25 is preferably drilled with a laser, since a precise passage point for the coolant can thus be created, which has a defect-free surface, which also enables the coolant to pass through the bore 25 regularly and cleanly.
- the bore 25 can be made at a defined angle to the vertical axis of the metal casing 20.
- the dome-shaped bottom of the metal casing 20, which surrounds the bore 25, is polished so that a the application capillary 1 can be securely closed with the closure provided for this purpose.
- the metal casing 20 has a thickness of at most 0.15 mm and consists of metal, preferably at least partially of gold, or is coated with gold on the outward-facing side. Another biocompatible material that complies with DIN EN 30993-1 can also replace gold.
- the layer of polymeric material 23 on the inside of the metal casing 20 surrounds a channel 24 through which the cryogenic cooling liquid flows.
- the channel 24 has a constant diameter over its entire length, preferably of 0.1-1 mm, particularly preferably of 0.5 mm.
- the configuration of the exit point ensures that the pressure, volume or temperature of the cryogenic cooling liquid do not change significantly when passing through the channels 24 and 26 and the bore 25. This configuration thus prevents undesired two-phase formation of a two-phase mixture and the undesired formation of ice crystals. Accordingly, the cryogenic cooling medium is kept in a single liquid phase when it emerges from the application capillary.
- a Joule-Thomson effect is prevented because the cryogenic cooling liquid does not pass a narrowing cross section when it passes through the bore 25.
- the metal jacket 20 of the application capillary 1 stabilizes the layer of polymeric material 23.
- the polymeric material 23 reduces the freezing of the application capillary 1 when the cryogenic cooling liquid flows through the metal jacket 20. There is therefore no frosting of the outer surface of the application capillary 1, which is why there is no blockage due to freezing in the bore 25.
- a preferred polymeric material is polytetrafluoroethylene (PTFE).
- PTFE polytetrafluoroethylene
- other polymeric materials that meet the requirements for biocom- compatibility, thermal resistance and chemically inert properties.
- a separate cannula made of biocompatible plastic can also be inserted into the metal jacket 20 and in frictional contact with it.
- the thermal insulation 16 can consist of conventional insulating materials and is designed such that it contacts the upper end 21 of the metal jacket 20. In a preferred embodiment, the thermal
- Insulating material 16 an internal thread, which is not shown in the drawing and which engages in an external thread of the metal casing 20, which is located at the upper end of the metal casing 20 and is also not shown. This enables the metal casing 20 to be exchanged quickly. Therefore, a metal jacket 20 of different diameters can be used to control the amount of cryogenic coolant that is delivered to the site to be treated. This prevents wastage of cryogenic coolant and minimizes the destruction of healthy tissue.
- the microfilter 17 is attached to the thermal insulation 16 between the upper and lower O-rings 18, 19.
- the lower end of the O-ring 19 touches the upper end of the metal casing 20.
- the lower and the upper O-ring 18, 19 are preferably made of polymeric material and are designed such that they are held in the thermal insulating body 16 by frictional forces ,
- the O-rings 18, 19 enclose a channel 26, which preferably has a diameter that is the same size as the diameter of the channel 24.
- FIG. 5 shows a hand-held device according to the invention, which is particularly suitable for mobile use. It includes one Capsule 27, which contains the cryogenic liquid gas 28. A tube 29 is attached to the capsule 27, which pierces a closure 30 and is equipped with a valve 31 which enables the cryogenic cooling medium to be discharged and finely metered.
- the application capillary 1 according to the invention is plugged onto the tube 29, which contains a wire 32 which runs in the longitudinal direction of the application capillary 1 and extends to the exit point of the application capillary 1 and thus forms an annular free cross section through which the cryogenic cooling liquid is in the form can leak from drops.
- the handheld device is equipped with means that allow flexible replacement of the application capillaries. Screw threads that are not shown in the figure can be mentioned here by way of example.
- FIG. 6 shows a closure for the application capillary according to the invention. It comprises a cap 33 which has an internal thread 34 which engages in a screw 35 which surrounds the application capillary 1. At the closed end of the cap 33 there is an adjustable screw connection with an adjusting screw 36 which is arranged in the cap 33. In the cap 33, an annular stop 37 is incorporated, which extends from the inner wall of the cap 33 in the middle. A spring 38 is attached to the adjusting screw 36, which allows an anvil-shaped snap-back body 39 to snap back when the application capillary 1 enters the cap 33.
- the snap-back body 39 preferably consists of a material which does not damage the sensitive application capillary, preferably of PTFE.
- ventilation channels 40, 41 preferably two ventilation channels, adjacent to the internal thread 34.
- FIG. 7 shows components of a further preferred embodiment of an applicator according to the invention.
- the applicator comprises an application capillary 1, which is arranged in a channel 50 of a capsule piercing part 51.
- the capsule piercing part 51 is provided with two external threads 35 and 52.
- the external thread 35 serves to write down a closure cap 33 for the nozzle opening.
- the closure cap 33 has an internal thread 34, so that it can be screwed to the capsule piercing part 51.
- the closure cap 33 preferably has a seal which is supported by a pressure-generating means, for example a spring.
- a heat conductor 53 made of a material that is as good a heat conductor as possible, for example a metal, within the application capillary.
- the heat conductor 53 is rod-shaped and, in its installed state, extends along the application capillary 1.
- the application capillary 1 is located in sections within the channel 50 of the capsule piercing part 51.
- the capsule piercing part 51 contains a feed channel 54 for feeding the cryogenic gas into the application capillary 1.
- the feed channel 54 contains a micro- sieve 55 for the retention of impurities.
- the capsule piercing part 51 can be connected to an adapter 56 via the external thread 52.
- the adapter 56 has an internal thread 57 into which the external thread 52 of the capsule piercing part 51 can be screwed.
- the adapter 56 preferably has a further internal thread 58 for screw connection with an external thread 59 of a gas capsule 60.
- seal 61 which in a particularly expedient embodiment consists of polytetrafluoroethylene.
- the application capillary consists of a microcapillary, which is applied to a supply source for the cryogenic cooling liquid.
- This supply source can be a handheld device according to the invention according to FIG. 5 or a larger stationary supply unit.
- cryogenic cooling liquid takes place particularly well with a capillary diameter between 30 and 40 ⁇ m, in particular 33 and 37 ⁇ m, since liquids with a viscosity and an inner diameter are used in these capillary cross sections
- Friction like that of liquid gases have particularly good flow and metering properties.
- the application capillaries according to the invention are fundamentally to be used for all cryogenic gases, but due to their individual design they can meet different boundary conditions.
- the task in particular biological material such as skin tissue, is subcooled selectively with minimal consumption of cryogenic cooling liquid in such a way that the remaining tissue in the treatment periphery remains undamaged in that the application capillary 1 with a constriction 5 is equipped, which ensures a distance in the form of the cavity 6 between the tip 4 and the channel 2, into which the cryogenic cooling liquid can penetrate to evaporate there.
- the tissue surrounding the opening 7 is then cooled either by the direct contact of the cryogenic coolant gas with the tissue or by the heat removal that arises in the tissue in that the cryogenic coolant evaporates in the cavity 6 and extracts the energy required for evaporation from the tissue ,
- the cooling remains limited to the location of the exit of the cryogenic coolant gas, which is predetermined by the cavity 6, according to the object of the invention. This means that even in deeper tissue layers, selective cooling can take place without unnecessary coolant losses.
- Figures 1 to 3 illustrated embodiments get along especially without thermal insulation along the capillary path if liquid N 2 0 is used as the coolant.
- the liquid N 2 0 at room temperature of about 20 ° C is brought directly through the microcapillary in a dimension of less than 1 mm directly to the cavity 6, so that no ice can form due to the influence of cold at the exit point or along the capillary.
- the cooling Liquid then comes either in an embodiment with an open tip directly in the tissue, subcutaneously, or in the cavity 6 for relaxation. According to the invention, icing only takes place here.
- the gaseous medium formed during the evaporation of the cryogenic liquid does not cause a freezing zone, in particular in the puncture area, which is above the point to be cooled, and is additionally heated by introducing the warm liquid gas.
- the evaporation energy of the liquid phase is used directly for icing without any noteworthy losses and thus ideally approximates the theoretically required refrigerant requirement.
- the miniaturization of the device does not burden the patient.
- the application capillary 1 according to FIG. 1 is preferably made of stainless steel and does not require the use of polymeric insulation material. N 2 O or liquid argon, for example, can be used as cooling liquids. In particular, when using these cooling liquids, there is no formation of an ice ball at the exit point. At an application pressure of 5 bar, the coolant is evaporated and escapes along the outer walls of the application capillary to the surface of the skin. This embodiment is particularly easy to manufacture.
- the insulation results in particular advantages.
- evaporation losses are prevented, and on the other hand, frosting in particular of the inner walls is prevented, which prevents ice crystal formation, which can lead to malfunctions up to the closure of the application capillary, since the ice crystals cannot be avoided even in liquid gases and can settle on the inner wall of the application capillary
- the suppression of the tires is special an effect of the metal sheath, for example 0.15 mm thick and is reinforced by the material pairing metal / plastic and special PTFE.
- the metal sheathing stabilizes the PTFE or another plastic that is used in the application capillary.
- the thin-walled design of the metal casing enables dimensionally stable and economical laser drilling of the nozzle.
- the operating pressure used for all embodiments of the invention is in the order of magnitude up to approximately 5 bar, an upper limit of 3 bar being even more expedient and a setting of the operating pressure between 0.1 bar and 0.3 bar being particularly advantageous. This applies both to the application of the application capillary using a hand-held device according to FIG. 5 and to its use with a stationary supply unit for liquid gases, which is connected to the application capillary by means of a line.
- the application capillary preferably consists of stainless steel or medical steel. It can also consist at least partially of gold or another biocompatible material that corresponds to the standard DIN EN 30993-1. These materials can preferably be located on the side of the application capillary that comes into contact with the tissue and or also entirely on the inside of the application capillary.
- the outside diameter of the application capillary according to the invention is less than 1.5 mm, better less than 1 mm, the preferred inside diameter of the application capillary is between 0.3 and 0.7 mm, preferably 0.5 mm, and the exit point for the cryogenic cooling liquid has a preferred diameter of 30- 40 ⁇ m, particularly useful from 33-37 ⁇ m.
- the application capillary with its nozzle or exit point, can form a cavity for the cryogenic cooling liquid, which allows the cooling liquid to evaporate at its exit point.
- This evaporation extracts heat from the flowing cooling liquid and thus prevents an interruption of the flowing liquid flow, which would otherwise be interrupted by gas bubbles.
- a continuous flow of coolant is therefore possible, which is not interrupted, which is particularly effective for the cooling process.
- the application capillary can also be equipped with a wire which is embedded in the capillary in the axial direction. This leads to improved dosing properties since the pressure for application is reduced. In a broader sense, another means of narrowing the outlet cross section also serves this purpose.
- outlet openings for the cryogenic coolant are arranged at an angle to the longitudinal axis of the application capillary, flow directions of the coolant can be achieved which cool the tissue that is difficult to access. enable places.
- a polished surface also enables a secure closure, in particular if the tip of the application capillary is cup-shaped or dome-shaped or dome-shaped.
- the application capillary according to the invention is preceded by a microfilter which retains microorganisms and thus contributes to hygiene.
- the application capillary has a thread-like profile in order to be variably connected to a supply device, e.g. Handheld device can be connected.
- a supply device e.g. Handheld device can be connected.
- another fastening means such as a plug closure, can also take the place of the thread.
- the application capillaries according to the invention can all be connected both to a large stationary liquid gas source and to a hand-held device, as is shown by way of example in FIG. 5.
- the capsule 27 is filled to about 3/4 of its volume with an amount of the cryofluid which is maintained at a substantially constant pressure of approximately 50 bar.
- the tube defines an elongated channel, not shown, through which the cryogenic coolant can pass.
- the closure 30 ensures a secure connection of the tube 29 to the capsule 27.
- the valve 31 allows the cryogenic coolant to pass into the application capillary 1.
- the valve 31 is designed as a spring-loaded valve. However, other valve configurations can also be used.
- the user of the cryogenic device presses the valve 31 so that the cryogenic cooling liquid can escape through the application capillary 1 and emerge from the handheld device in the form of drops.
- the cryogenic coolant such as N 2 O
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE20023779U DE20023779U1 (en) | 1999-12-07 | 2000-12-05 | Applicator for the application of cryogenic cooling media and application device |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19958988 | 1999-12-07 | ||
DE1999158988 DE19958988A1 (en) | 1999-12-07 | 1999-12-07 | Applicator for cryogenic liquids consists of a capillary unit with a nozzle and a pointed end. |
DE19961722 | 1999-12-21 | ||
DE1999161722 DE19961722A1 (en) | 1999-12-21 | 1999-12-21 | Applicator for cryogenic liquids consists of a capillary unit with a nozzle and a pointed end. |
DE10040583 | 2000-08-15 | ||
DE10040583 | 2000-08-15 | ||
JP2000321774 | 2000-10-20 | ||
JP2000321774A JP2001178737A (en) | 1999-12-07 | 2000-10-20 | Freezer device |
PCT/DE2000/004331 WO2001041683A2 (en) | 1999-12-07 | 2000-12-05 | Applicator for the application of cryogenic refrigerants and application device |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1408861A2 true EP1408861A2 (en) | 2004-04-21 |
Family
ID=27437862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00993305A Withdrawn EP1408861A2 (en) | 1999-12-07 | 2000-12-05 | Applicator for the application of cryogenic refrigerants and application device |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1408861A2 (en) |
AU (1) | AU2828401A (en) |
DE (2) | DE10083688D2 (en) |
WO (1) | WO2001041683A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4605809B2 (en) * | 2004-06-27 | 2011-01-05 | シュタインファット ディーター | Low temperature medium metering device for fine metering of cryogenic liquefied gas |
WO2008035331A1 (en) * | 2006-09-18 | 2008-03-27 | Arbel Medical Ltd. | Cryosurgical instrument |
US7967814B2 (en) | 2009-02-05 | 2011-06-28 | Icecure Medical Ltd. | Cryoprobe with vibrating mechanism |
US8162812B2 (en) | 2009-03-12 | 2012-04-24 | Icecure Medical Ltd. | Combined cryotherapy and brachytherapy device and method |
US7967815B1 (en) | 2010-03-25 | 2011-06-28 | Icecure Medical Ltd. | Cryosurgical instrument with enhanced heat transfer |
US7938822B1 (en) | 2010-05-12 | 2011-05-10 | Icecure Medical Ltd. | Heating and cooling of cryosurgical instrument using a single cryogen |
US8080005B1 (en) | 2010-06-10 | 2011-12-20 | Icecure Medical Ltd. | Closed loop cryosurgical pressure and flow regulated system |
DE102015205367A1 (en) | 2015-03-24 | 2016-09-29 | Pharmpur Gmbh | cryotip |
NL2020965B1 (en) | 2018-05-22 | 2019-11-28 | Crea Ip B V | Tool for cryosurgery |
US11633224B2 (en) | 2020-02-10 | 2023-04-25 | Icecure Medical Ltd. | Cryogen pump |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4211231A (en) * | 1978-05-15 | 1980-07-08 | Cryomedics, Inc. | Cryosurgical instrument |
DE3624787A1 (en) * | 1985-07-23 | 1987-01-29 | Karin Schmidtke | Cooling and freezing probe |
US4802475A (en) * | 1987-06-22 | 1989-02-07 | Weshahy Ahmed H A G | Methods and apparatus of applying intra-lesional cryotherapy |
GB2244922A (en) * | 1990-06-01 | 1991-12-18 | Cryogenic Instr & Equipment Li | Cryogenic device |
-
2000
- 2000-12-05 AU AU28284/01A patent/AU2828401A/en not_active Abandoned
- 2000-12-05 WO PCT/DE2000/004331 patent/WO2001041683A2/en not_active Application Discontinuation
- 2000-12-05 DE DE10083688T patent/DE10083688D2/en not_active Expired - Fee Related
- 2000-12-05 EP EP00993305A patent/EP1408861A2/en not_active Withdrawn
- 2000-12-05 DE DE20023779U patent/DE20023779U1/en not_active Expired - Lifetime
Non-Patent Citations (1)
Title |
---|
See references of WO0141683A3 * |
Also Published As
Publication number | Publication date |
---|---|
DE10083688D2 (en) | 2005-07-07 |
WO2001041683A2 (en) | 2001-06-14 |
WO2001041683A3 (en) | 2002-03-28 |
WO2001041683A9 (en) | 2002-09-06 |
AU2828401A (en) | 2001-06-18 |
DE20023779U1 (en) | 2006-06-01 |
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