EP1404860A4 - Delivery system for nucleic acids - Google Patents
Delivery system for nucleic acidsInfo
- Publication number
- EP1404860A4 EP1404860A4 EP02741778A EP02741778A EP1404860A4 EP 1404860 A4 EP1404860 A4 EP 1404860A4 EP 02741778 A EP02741778 A EP 02741778A EP 02741778 A EP02741778 A EP 02741778A EP 1404860 A4 EP1404860 A4 EP 1404860A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- nucleic acids
- delivery system
- delivery
- nucleic
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29430901P | 2001-05-30 | 2001-05-30 | |
| US294309P | 2001-05-30 | ||
| US34589101P | 2001-10-29 | 2001-10-29 | |
| US345891P | 2001-10-29 | ||
| PCT/US2002/017157 WO2002097116A2 (en) | 2001-05-30 | 2002-05-30 | Delivery system for nucleic acids |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| EP1404860A2 EP1404860A2 (en) | 2004-04-07 |
| EP1404860A4 true EP1404860A4 (en) | 2007-11-14 |
| EP1404860B1 EP1404860B1 (en) | 2013-11-20 |
| EP1404860B8 EP1404860B8 (en) | 2013-12-25 |
Family
ID=26968451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02741778.1A Expired - Lifetime EP1404860B8 (en) | 2001-05-30 | 2002-05-30 | Delivery system for nucleic acids |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7514098B2 (en) |
| EP (1) | EP1404860B8 (en) |
| JP (1) | JP4323949B2 (en) |
| KR (1) | KR100904954B1 (en) |
| CN (1) | CN100384480C (en) |
| AU (1) | AU2002314855B2 (en) |
| CA (1) | CA2449054C (en) |
| ES (1) | ES2445328T3 (en) |
| MX (1) | MXPA03010893A (en) |
| RU (1) | RU2294192C2 (en) |
| WO (1) | WO2002097116A2 (en) |
| ZA (1) | ZA200309924B (en) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4750360B2 (en) * | 2001-10-22 | 2011-08-17 | ザ スクリプス リサーチ インスティチュート | Antibody targeting compounds |
| US7635463B2 (en) * | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| KR20110050745A (en) | 2002-10-03 | 2011-05-16 | 탈자진 인코포레이티드 | Vasculostatic agents and methods of use thereof |
| WO2004032709A2 (en) * | 2002-10-04 | 2004-04-22 | Caritas St.Elisabeth's Medical Center Of Boston, Inc. | Inhibition of src for treatment of reperfusion injury related to revascularization |
| WO2004070009A2 (en) * | 2003-01-31 | 2004-08-19 | Targesome Inc. | Targeted multivalent macromolecules |
| EP1643971A2 (en) * | 2003-05-22 | 2006-04-12 | Neopharm, Inc. | Liposomal formulations comprising a combination of two or more active agents |
| AU2011250847B2 (en) * | 2003-06-23 | 2013-06-20 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
| US20050196343A1 (en) * | 2004-02-27 | 2005-09-08 | Molecular Therapeutics, Inc. | Degradable nanoparticles |
| AU2005326962A1 (en) | 2004-12-22 | 2006-08-17 | Bellus Health (International) Limited | Methods and compositions for treating amyloid-related diseases |
| WO2006138145A1 (en) | 2005-06-14 | 2006-12-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| EP1930029A4 (en) * | 2005-09-27 | 2013-02-27 | Sumitomo Bakelite Co | Particle for medical use and process for producing the same |
| WO2007127366A2 (en) | 2006-04-25 | 2007-11-08 | Targegen, Inc. | Kinase inhibitors and methods of use thereof |
| EA016568B1 (en) | 2006-10-12 | 2012-05-30 | Беллус Хелс (Интернэшнл) Лимитед | Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid |
| US8507200B2 (en) | 2007-02-09 | 2013-08-13 | Northwestern University | Particles for detecting intracellular targets |
| US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| WO2008151049A2 (en) * | 2007-05-30 | 2008-12-11 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| WO2009074569A1 (en) * | 2007-12-11 | 2009-06-18 | Bracco International Bv | Targeting and therapeutic compounds with a polyproline-comprising spacer and gas-filled microvesicles comprising said compounds |
| WO2009129227A1 (en) | 2008-04-17 | 2009-10-22 | Pds Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
| WO2010042555A2 (en) * | 2008-10-06 | 2010-04-15 | The Brigham And Women's Hospital, Inc. | Particles with multiple functionalized surface domains |
| MX2011005429A (en) | 2008-11-24 | 2011-06-21 | Univ Northwestern | Polyvalent rna-nanoparticle compositions. |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| GB0901857D0 (en) * | 2009-02-05 | 2009-03-11 | Nanoco Technologies Ltd | Encapsulated nanoparticles |
| WO2010094043A2 (en) * | 2009-02-13 | 2010-08-19 | University Of Washington | Gadolinium expressed lipid nanoparticles for magnetic resonance imaging |
| IT1398857B1 (en) * | 2009-06-10 | 2013-03-21 | Univ Padova | FOSPHOLIPID POLYMERIC CONJUGATES |
| EP2494075B1 (en) | 2009-10-30 | 2018-04-04 | Northwestern University | Templated nanoconjugates |
| RU2573409C2 (en) * | 2009-11-04 | 2016-01-20 | Дзе Юниверсити Оф Бритиш Коламбиа | Lipid particles containing nucleic acids and related methods |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| EP4066819B1 (en) * | 2010-08-31 | 2023-03-01 | GlaxoSmithKline Biologicals SA | Small liposomes for delivery of immunogen-encoding rna |
| WO2012040184A2 (en) * | 2010-09-20 | 2012-03-29 | Merck Sharp & Dohme Corp. | Novel low molecular weight cationic lipids for oligonucleotide delivery |
| CA2813466A1 (en) | 2010-10-01 | 2012-04-05 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids that disrupt major groove binding partner interactions |
| AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| EP2709590A4 (en) * | 2011-05-11 | 2015-05-13 | Nanovalent Pharmaceuticals Inc | Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor |
| US10016517B2 (en) | 2011-08-08 | 2018-07-10 | Rutgers, The State University Of New Jersey | Bioactive amphiphilic polymer stabilized nanoparticles with enhanced stability and activity |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2847698C (en) | 2011-09-14 | 2020-09-01 | Northwestern University | Nanoconjugates able to cross the blood-brain barrier |
| CN110511939A (en) | 2011-10-03 | 2019-11-29 | 现代泰克斯公司 | Nucleosides, nucleotide and nucleic acid of modification and application thereof |
| EP2791160B1 (en) | 2011-12-16 | 2022-03-02 | ModernaTX, Inc. | Modified mrna compositions |
| US9737480B2 (en) * | 2012-02-06 | 2017-08-22 | President And Fellows Of Harvard College | ARRDC1-mediated microvesicles (ARMMs) and uses thereof |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| EP2833923A4 (en) | 2012-04-02 | 2016-02-24 | Moderna Therapeutics Inc | Modified polynucleotides for the production of proteins |
| WO2013172942A1 (en) | 2012-05-18 | 2013-11-21 | Purdue Research Foundation | Methods for isolating proteins |
| BR112014027834A2 (en) | 2012-05-23 | 2017-08-08 | Univ Ohio State | lipid nanoparticle compositions for antisense oligonucleotide delivery |
| EP2887954B1 (en) * | 2012-08-23 | 2020-05-06 | Susan Marie Metcalfe | Neurotherapeutic nanoparticle compositions |
| TWI672149B (en) | 2012-09-21 | 2019-09-21 | 美商Ｐｄｓ生技公司 | Improved vaccine compositions and methods of use |
| PT2922554T (en) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Terminally modified rna |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| KR101492168B1 (en) | 2013-04-29 | 2015-02-11 | 한국과학기술연구원 | Amphiphilic nucleic acid, nucleic acid complexes comprising the same and their use in the drug carrier |
| AU2014292926B2 (en) | 2013-07-25 | 2020-03-05 | Exicure Operating Company | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| SG11201602503TA (en) | 2013-10-03 | 2016-04-28 | Moderna Therapeutics Inc | Polynucleotides encoding low density lipoprotein receptor |
| TR201908550T4 (en) | 2014-06-04 | 2019-07-22 | Exicure Inc | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications. |
| CN106794262A (en) | 2014-07-31 | 2017-05-31 | 俄克拉何马大学董事会 | The isomerohydrolase active mutant high of mammal RPE65 |
| US9816080B2 (en) | 2014-10-31 | 2017-11-14 | President And Fellows Of Harvard College | Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) |
| CN107106493A (en) | 2014-11-21 | 2017-08-29 | 西北大学 | The sequence-specific cellular uptake of spherical nucleic acid nano particle conjugate |
| PT3350157T (en) | 2015-09-17 | 2022-03-18 | Modernatx Inc | Compounds and compositions for intracellular delivery of therapeutic agents |
| WO2017083820A1 (en) | 2015-11-13 | 2017-05-18 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
| ES2924407T3 (en) | 2015-12-10 | 2022-10-06 | Modernatx Inc | Compositions and methods for the delivery of therapeutic agents |
| ES2913626T3 (en) | 2015-12-22 | 2022-06-03 | Modernatx Inc | Compounds and compositions for the intracellular delivery of agents |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| EP3518981A4 (en) | 2016-10-03 | 2020-06-10 | President and Fellows of Harvard College | Delivery of therapeutic rnas via arrdc1-mediated microvesicles |
| WO2018089540A1 (en) | 2016-11-08 | 2018-05-17 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| ES2940259T3 (en) | 2017-03-15 | 2023-05-04 | Modernatx Inc | Compound and compositions for intracellular delivery of therapeutic agents |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| MA49421A (en) | 2017-06-15 | 2020-04-22 | Modernatx Inc | RNA FORMULATIONS |
| US11744801B2 (en) | 2017-08-31 | 2023-09-05 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| CN114728887A (en) | 2019-09-19 | 2022-07-08 | 摩登纳特斯有限公司 | Branched tail end lipid compounds and compositions for intracellular delivery of therapeutic agents |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998054347A1 (en) * | 1997-05-29 | 1998-12-03 | Institute Of Child Health | Integrin-targeting vectors having transfection activity |
| WO2001092543A2 (en) * | 2000-05-30 | 2001-12-06 | Ich Productions Limited | Improved methods of transfection |
| WO2002030473A1 (en) * | 2000-10-11 | 2002-04-18 | Targesome, Inc. | Targeted therapeutic agents |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5858784A (en) * | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| EP0760658B1 (en) | 1994-05-27 | 2002-11-13 | Merck & Co. Inc. | Compounds for inhibiting osteoclast-mediated bone resorption |
| US5512294A (en) * | 1994-08-05 | 1996-04-30 | Li; King C. | Targeted polymerized liposome contrast agents |
| US6132764A (en) * | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US20020022264A1 (en) * | 1995-05-26 | 2002-02-21 | Sullivan Sean M. | Delivery vehicles comprising stable lipid/nucleic acid complexes |
| US6521211B1 (en) * | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| DE19705450A1 (en) | 1997-02-13 | 1998-08-20 | Merck Patent Gmbh | Bicyclic aromatic amino acids |
| US6090800A (en) * | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| US6187335B1 (en) * | 1997-12-31 | 2001-02-13 | Orasomal Technologies, Inc. | Polymerizable fatty acids, phospholipids and polymerized liposomes therefrom |
| US6066123A (en) | 1998-04-09 | 2000-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of bioavailability by use of focused energy delivery to a target tissue |
| DE19850131A1 (en) | 1998-10-30 | 2000-05-04 | Merck Patent Gmbh | Chromenon and chromanone derivatives |
| US6852334B1 (en) * | 1999-04-20 | 2005-02-08 | The University Of British Columbia | Cationic peg-lipids and methods of use |
| EP1233752B1 (en) * | 1999-11-30 | 2005-01-26 | The Arizona Board of Regents on behalf of The University of Arizona | Radiation sensitive liposomes |
| US6372250B1 (en) | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
| AU2002256398A2 (en) * | 2001-04-30 | 2002-11-11 | Targeted Genetics Corporation | Lipid-comprising drug delivery complexes and methods for their production |
-
2002
- 2002-05-30 AU AU2002314855A patent/AU2002314855B2/en not_active Ceased
- 2002-05-30 US US10/159,241 patent/US7514098B2/en not_active Expired - Fee Related
- 2002-05-30 JP JP2003500281A patent/JP4323949B2/en not_active Expired - Fee Related
- 2002-05-30 RU RU2003137830/15A patent/RU2294192C2/en not_active IP Right Cessation
- 2002-05-30 ES ES02741778.1T patent/ES2445328T3/en not_active Expired - Lifetime
- 2002-05-30 MX MXPA03010893A patent/MXPA03010893A/en active IP Right Grant
- 2002-05-30 CA CA2449054A patent/CA2449054C/en not_active Expired - Fee Related
- 2002-05-30 US US10/158,761 patent/US7025987B2/en not_active Expired - Fee Related
- 2002-05-30 KR KR1020037015643A patent/KR100904954B1/en not_active IP Right Cessation
- 2002-05-30 EP EP02741778.1A patent/EP1404860B8/en not_active Expired - Lifetime
- 2002-05-30 CN CNB028149661A patent/CN100384480C/en not_active Expired - Fee Related
- 2002-05-30 WO PCT/US2002/017157 patent/WO2002097116A2/en active IP Right Grant
-
2003
- 2003-12-22 ZA ZA2003/09924A patent/ZA200309924B/en unknown
-
2006
- 2006-04-03 US US11/396,743 patent/US7803399B2/en not_active Expired - Fee Related
-
2008
- 2008-08-20 US US12/195,261 patent/US8163305B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998054347A1 (en) * | 1997-05-29 | 1998-12-03 | Institute Of Child Health | Integrin-targeting vectors having transfection activity |
| WO2001092543A2 (en) * | 2000-05-30 | 2001-12-06 | Ich Productions Limited | Improved methods of transfection |
| WO2002030473A1 (en) * | 2000-10-11 | 2002-04-18 | Targesome, Inc. | Targeted therapeutic agents |
Non-Patent Citations (1)
| Title |
|---|
| STORRS R W ET AL: "Paramagnetic polymerized liposomes: Synthesis, characterization, and applications for magnetic resonance imaging", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 117, no. 28, 19 July 1995 (1995-07-19), pages 7301 - 7306, XP002342157, ISSN: 0002-7863 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200309924B (en) | 2005-08-31 |
| CA2449054C (en) | 2011-01-04 |
| WO2002097116A2 (en) | 2002-12-05 |
| RU2003137830A (en) | 2005-03-27 |
| RU2294192C2 (en) | 2007-02-27 |
| ES2445328T3 (en) | 2014-03-03 |
| JP4323949B2 (en) | 2009-09-02 |
| US7025987B2 (en) | 2006-04-11 |
| EP1404860B1 (en) | 2013-11-20 |
| WO2002097116A3 (en) | 2003-05-22 |
| AU2002314855B2 (en) | 2007-08-09 |
| US8163305B2 (en) | 2012-04-24 |
| CN1535163A (en) | 2004-10-06 |
| KR20040035600A (en) | 2004-04-29 |
| US20030013674A1 (en) | 2003-01-16 |
| KR100904954B1 (en) | 2009-06-26 |
| US20030092655A1 (en) | 2003-05-15 |
| MXPA03010893A (en) | 2004-10-28 |
| US7803399B2 (en) | 2010-09-28 |
| US20090048201A1 (en) | 2009-02-19 |
| EP1404860B8 (en) | 2013-12-25 |
| CA2449054A1 (en) | 2002-12-05 |
| US20060188560A1 (en) | 2006-08-24 |
| US7514098B2 (en) | 2009-04-07 |
| EP1404860A2 (en) | 2004-04-07 |
| CN100384480C (en) | 2008-04-30 |
| JP2005506955A (en) | 2005-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20031222 |
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