EP1349961A4 - Methods for determining the biological effects of compounds on gene expression - Google Patents

Methods for determining the biological effects of compounds on gene expression

Info

Publication number
EP1349961A4
EP1349961A4 EP01992034A EP01992034A EP1349961A4 EP 1349961 A4 EP1349961 A4 EP 1349961A4 EP 01992034 A EP01992034 A EP 01992034A EP 01992034 A EP01992034 A EP 01992034A EP 1349961 A4 EP1349961 A4 EP 1349961A4
Authority
EP
European Patent Office
Prior art keywords
compounds
determining
methods
gene expression
biological effects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01992034A
Other languages
German (de)
French (fr)
Other versions
EP1349961A2 (en
Inventor
Christopher C Adams
Paul Labhart
Mary E Harper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genpathway Inc
Original Assignee
Cistem Molecular Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cistem Molecular Corp filed Critical Cistem Molecular Corp
Publication of EP1349961A2 publication Critical patent/EP1349961A2/en
Publication of EP1349961A4 publication Critical patent/EP1349961A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
EP01992034A 2000-11-13 2001-11-09 Methods for determining the biological effects of compounds on gene expression Withdrawn EP1349961A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24833900P 2000-11-13 2000-11-13
US248339P 2000-11-13
PCT/US2001/046927 WO2002038734A2 (en) 2000-11-13 2001-11-09 Methods for determining the biological effects of compounds on gene expression

Publications (2)

Publication Number Publication Date
EP1349961A2 EP1349961A2 (en) 2003-10-08
EP1349961A4 true EP1349961A4 (en) 2005-01-26

Family

ID=22938682

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01992034A Withdrawn EP1349961A4 (en) 2000-11-13 2001-11-09 Methods for determining the biological effects of compounds on gene expression

Country Status (4)

Country Link
EP (1) EP1349961A4 (en)
AU (1) AU2002232510A1 (en)
CA (1) CA2431047A1 (en)
WO (1) WO2002038734A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040058356A1 (en) * 2001-03-01 2004-03-25 Warren Mary E. Methods for global profiling gene regulatory element activity
US7981842B2 (en) 2001-06-08 2011-07-19 Panomics, Inc. Method for detecting transcription factor-protein interactions
WO2002101351A2 (en) * 2001-06-08 2002-12-19 Panomics, Inc. Method for detecting transcription factor-protein interactions
CA3094974A1 (en) * 2018-03-23 2019-09-26 Whitehead Institute For Biomedical Research Methods and assays for modulating gene transcription by modulating condensates
CN108548780A (en) * 2018-03-30 2018-09-18 中国人民解放军第二军医大学 The method of transcription factor chip agent box and high flux screening target gene transcription factor
SG11202106690QA (en) 2019-02-08 2021-07-29 Dewpoint Therapeutics Inc Methods of characterizing condensate-associated characteristics of compounds and uses thereof
US20220390432A1 (en) * 2019-05-15 2022-12-08 Whitehead Institute For Biomedical Research Methods of characterizing and utilizing agent-condensate interactions
KR20220084047A (en) 2019-09-18 2022-06-21 듀포인트 테라퓨틱스, 인크. Screening methods for condensate-related specificity and uses thereof
CN116801872A (en) * 2021-02-10 2023-09-22 上海奕拓医药科技有限责任公司 Methods of modulating androgen receptor coacervates

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0620439A2 (en) * 1993-04-16 1994-10-19 Roche Diagnostics GmbH Method of determining the binding of transcription factors to nucleic acids
US5821053A (en) * 1995-02-10 1998-10-13 Center For Blood Research, Inc. LIL-Stat DNA binding sites and methods for identifying inhibitory binding agents
WO1999019510A1 (en) * 1997-10-10 1999-04-22 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
US6066452A (en) * 1997-08-06 2000-05-23 Yale University Multiplex selection technique for identifying protein-binding sites and DNA-binding proteins
US6100035A (en) * 1998-07-14 2000-08-08 Cistem Molecular Corporation Method of identifying cis acting nucleic acid elements
EP1136567A1 (en) * 2000-03-24 2001-09-26 Advanced Array Technologies S.A. Method and kit for the screening, the detection and /or the quantification of transcriptional factors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5986055A (en) * 1997-11-13 1999-11-16 Curagen Corporation CDK2 interactions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0620439A2 (en) * 1993-04-16 1994-10-19 Roche Diagnostics GmbH Method of determining the binding of transcription factors to nucleic acids
US5821053A (en) * 1995-02-10 1998-10-13 Center For Blood Research, Inc. LIL-Stat DNA binding sites and methods for identifying inhibitory binding agents
US6066452A (en) * 1997-08-06 2000-05-23 Yale University Multiplex selection technique for identifying protein-binding sites and DNA-binding proteins
WO1999019510A1 (en) * 1997-10-10 1999-04-22 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
US6100035A (en) * 1998-07-14 2000-08-08 Cistem Molecular Corporation Method of identifying cis acting nucleic acid elements
EP1136567A1 (en) * 2000-03-24 2001-09-26 Advanced Array Technologies S.A. Method and kit for the screening, the detection and /or the quantification of transcriptional factors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BULYK M L ET AL: "Quantifying DNA-protein interactions by double-stranded DNA arrays", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, June 1999 (1999-06-01), pages 573 - 577, XP002168458, ISSN: 1087-0156 *
BULYK MARTHA L ET AL: "Exploring the DNA-binding specificities of zinc fingers with DNA microarrays", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 98, no. 13, 19 June 2001 (2001-06-19), pages 7158 - 7163, XP002174591, ISSN: 0027-8424 *
DUCY P ET AL: "TWO DISTINCT OSTEOBLAST-SPECIFIC CIS-ACTING ELEMENTS CONTROL EXPRESSION OF A MOUSE OSTEOCALCIN GENE", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 15, no. 4, April 1995 (1995-04-01), pages 1858 - 1869, XP001152915, ISSN: 0270-7306 *
See also references of WO0238734A3 *

Also Published As

Publication number Publication date
AU2002232510A1 (en) 2002-05-21
WO2002038734A3 (en) 2002-07-11
EP1349961A2 (en) 2003-10-08
WO2002038734A2 (en) 2002-05-16
CA2431047A1 (en) 2002-05-16

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Legal Events

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Effective date: 20041209

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Ipc: 7C 12Q 1/68 A

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Owner name: GENPATHWAY, INC.

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Effective date: 20051025