EP1196150A4 - Silver-containing, sol-gel derived bioglass compositions - Google Patents

Silver-containing, sol-gel derived bioglass compositions

Info

Publication number
EP1196150A4
EP1196150A4 EP00939832A EP00939832A EP1196150A4 EP 1196150 A4 EP1196150 A4 EP 1196150A4 EP 00939832 A EP00939832 A EP 00939832A EP 00939832 A EP00939832 A EP 00939832A EP 1196150 A4 EP1196150 A4 EP 1196150A4
Authority
EP
European Patent Office
Prior art keywords
compositions
sol
silver
gel derived
implanted materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00939832A
Other languages
German (de)
French (fr)
Other versions
EP1196150A1 (en
EP1196150B1 (en
Inventor
Maria Bellantone
Nichola J Coleman
Larry L Hench
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ip2ipo Innovations Ltd
Original Assignee
Imperial College Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial College Innovations Ltd filed Critical Imperial College Innovations Ltd
Publication of EP1196150A1 publication Critical patent/EP1196150A1/en
Publication of EP1196150A4 publication Critical patent/EP1196150A4/en
Application granted granted Critical
Publication of EP1196150B1 publication Critical patent/EP1196150B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C1/00—Ingredients generally applicable to manufacture of glasses, glazes, or vitreous enamels
    • C03C1/006—Ingredients generally applicable to manufacture of glasses, glazes, or vitreous enamels to produce glass through wet route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C13/00—Fibre or filament compositions
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C14/00—Glass compositions containing a non-glass component, e.g. compositions containing fibres, filaments, whiskers, platelets, or the like, dispersed in a glass matrix
    • C03C14/008—Glass compositions containing a non-glass component, e.g. compositions containing fibres, filaments, whiskers, platelets, or the like, dispersed in a glass matrix the non-glass component being in molecular form
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C3/00—Glass compositions
    • C03C3/04—Glass compositions containing silica
    • C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
    • C03C3/078—Glass compositions containing silica with 40% to 90% silica, by weight containing an oxide of a divalent metal, e.g. an oxide of zinc
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C3/00—Glass compositions
    • C03C3/04—Glass compositions containing silica
    • C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
    • C03C3/097—Glass compositions containing silica with 40% to 90% silica, by weight containing phosphorus, niobium or tantalum
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C4/00—Compositions for glass with special properties
    • C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C8/00—Enamels; Glazes; Fusion seal compositions being frit compositions having non-frit additions
    • C03C8/02—Frit compositions, i.e. in a powdered or comminuted form
    • C03C8/08—Frit compositions, i.e. in a powdered or comminuted form containing phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C2204/00—Glasses, glazes or enamels with special properties
    • C03C2204/02—Antibacterial glass, glaze or enamel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Silver-containing, sol-gel derived bioactive glass compositions and methods of preparation and use thereof are disclosed. The compositions can be in the form of particles, fibers and/or coatings, among other possible forms, and can be used, for example, for treating wounds, improving the success of skin grafts, reducing the inflammatory response and providing anti-bacterial treatments to a patient in need thereof. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating the compositions into or onto the implanted materials. The compositions can also be used to prepare devices used for in vitro and ex vivo cell culture.
EP00939832A 1999-06-14 2000-06-14 Silver-containing, sol-gel derived bioglass compositions Expired - Lifetime EP1196150B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13901499P 1999-06-14 1999-06-14
US139014P 1999-06-14
PCT/US2000/016207 WO2000076486A1 (en) 1999-06-14 2000-06-14 Silver-containing, sol-gel derived bioglass compositions

Publications (3)

Publication Number Publication Date
EP1196150A1 EP1196150A1 (en) 2002-04-17
EP1196150A4 true EP1196150A4 (en) 2003-01-02
EP1196150B1 EP1196150B1 (en) 2005-08-24

Family

ID=22484737

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00939832A Expired - Lifetime EP1196150B1 (en) 1999-06-14 2000-06-14 Silver-containing, sol-gel derived bioglass compositions

Country Status (10)

Country Link
US (1) US6482444B1 (en)
EP (1) EP1196150B1 (en)
AT (1) ATE302621T1 (en)
AU (1) AU5485200A (en)
CA (1) CA2377402C (en)
DE (1) DE60022197T2 (en)
DK (1) DK1196150T3 (en)
ES (1) ES2245644T3 (en)
PT (1) PT1196150E (en)
WO (1) WO2000076486A1 (en)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524335B2 (en) 1997-05-30 2009-04-28 Smith & Nephew, Inc. Fiber-reinforced, porous, biodegradable implant device
DE10081907D2 (en) * 1999-07-09 2002-08-29 Schott Glas Preservatives for perishable preparations, in particular for cosmetic and pharmaceutical preparations
US20040037871A1 (en) * 1999-10-20 2004-02-26 Healy David Michael Suture material
AU2001249510A1 (en) 2000-03-27 2001-10-08 Schott Glas New cosmetic, personal care, cleaning agent, and nutritional supplement compositions comprising bioactive glass and methods of making and using the same
US20040191329A1 (en) * 2000-07-27 2004-09-30 Burrell Robert E. Compositions and methods of metal-containing materials
US20030180379A1 (en) 2000-07-27 2003-09-25 Burrell Robert E. Solutions and aerosols of metal-containing compounds
EP1309279A4 (en) * 2000-08-17 2008-04-09 Tyco Healthcare Sutures and coatings made from therapeutic absorbable glass
FI20010523A0 (en) * 2001-03-16 2001-03-16 Yli Urpo Antti Treatment of sols, gels and mixtures thereof
US7597900B2 (en) 2001-03-27 2009-10-06 Schott Ag Tissue abrasives
DE10122262A1 (en) * 2001-05-08 2002-11-21 Schott Glas Polymers with bioactive glass with an antimicrobial effect
ATE548056T1 (en) * 2001-05-25 2012-03-15 Imp College Innovations Ltd BIOACTIVE FOAMED SOL-GEL AND PRODUCTION THEREOF
ATE332879T1 (en) 2001-08-22 2006-08-15 Schott Ag ANTIMICROBIAL, ANTI-INFLAMMATORY, WOUND-HEALING GLASS POWDER AND USE THEREOF
DE10293768B4 (en) * 2001-08-22 2011-05-12 Schott Ag Antimicrobial glass powder, its use and process for its preparation
DE10293767B4 (en) 2001-08-22 2017-06-08 Schott Ag Disinfectant glass powder with antimicrobial, anti-inflammatory, wound-healing effect and its use
DE10141117A1 (en) * 2001-08-22 2003-03-13 Schott Glas Antimicrobial silicate glass and its use
DE10141230A1 (en) * 2001-08-22 2003-03-13 Schott Glas Color additive including a glass with an antimicrobial effect
US7303817B2 (en) 2001-10-24 2007-12-04 Weitao Jia Dental filling material
US7750063B2 (en) 2001-10-24 2010-07-06 Pentron Clinical Technologies, Llc Dental filling material
US7204874B2 (en) 2001-10-24 2007-04-17 Pentron Clinical Technologies, Llc Root canal filling material
ES2244826T3 (en) * 2001-12-12 2005-12-16 Schott Ag USE OF AN ANTIMICROBIAL VITROCERAMIC FOR DENTAL CARE AND ORAL HYGIENE.
US8580291B2 (en) * 2002-03-15 2013-11-12 The Trustees Of The University Of Pennsylvania Fibrous composite for tissue engineering
WO2003082358A1 (en) * 2002-03-28 2003-10-09 Schott Glas Use of glass and/or glass ceramics in the form of powder or fibers for the controlled release of ions
GB0208642D0 (en) * 2002-04-16 2002-05-22 Accentus Plc Metal implants
DE10243132B4 (en) * 2002-09-17 2006-09-14 Biocer Entwicklungs Gmbh Anti-infective, biocompatible titanium oxide coatings for implants and methods of making them
EP1549253A4 (en) * 2002-09-26 2010-11-03 Endovascular Devices Inc Apparatus and method for delivery of mitomycin through an eluting biocompatible implantable medical device
AU2003900617A0 (en) * 2003-02-12 2003-02-27 Australian Surgical Design And Manufacture Pty Limited Surface preparation of an implant
DE102004008931B4 (en) * 2003-02-25 2008-01-17 Schott Ag Use of porous glasses, glass ceramics, glass powders or glass ceramic powders in kosimetric, medical, biocidal formulations
DE10316156B3 (en) * 2003-04-09 2004-10-14 Beiersdorf Ag Antimicrobial polymer materials and their use as a wound dressing
US20040220534A1 (en) * 2003-04-29 2004-11-04 Martens Paul W. Medical device with antimicrobial layer
DE10328261B4 (en) 2003-06-23 2007-10-25 Beiersdorf Ag Disinfecting coating with silver coating and its use
NZ543643A (en) * 2003-06-23 2007-09-28 Beiersdorf Ag Antimicrobial wound dressing with two layers and antimicrobial metal between layers but not on exterior
US20050008861A1 (en) * 2003-07-08 2005-01-13 Nanoproducts Corporation Silver comprising nanoparticles and related nanotechnology
DE10332011A1 (en) * 2003-07-14 2005-02-17 Schott Ag Use of glass compositions to achieve an antioxidant effect
GB0405680D0 (en) * 2004-03-13 2004-04-21 Accentus Plc Metal implants
AU2005237985B2 (en) 2004-04-20 2010-10-21 Genzyme Corporation Surgical mesh-like implant
DE102004021700A1 (en) * 2004-04-30 2005-11-24 Schott Ag Silicon-containing, phosphorus-free glass powders are used (especially in a polymer matrix) to treat skin defects such as wrinkles, scars or keloids
ITTO20040854A1 (en) * 2004-12-02 2005-03-02 Torino Politecnico WORKING PROCEDURE FOR GLASS, CERAMIC AND GLASS SURFACES FOR THE IMPLEMENTATION OF IMPLANTABLE DEVICES WITH ANTIBACTERIAL ACTION
US20060188580A1 (en) * 2005-02-03 2006-08-24 Ralph Sacks Anti-microbial granules
WO2006110393A1 (en) 2005-04-04 2006-10-19 The Regents Of The University Of California Inorganic materials for hemostatic modulation and therapeutic wound healing
US9326995B2 (en) 2005-04-04 2016-05-03 The Regents Of The University Of California Oxides for wound healing and body repair
US7754194B2 (en) * 2005-04-06 2010-07-13 L'oréal Hair relaxer compositions utilizing bioactive glass
JP2009501065A (en) * 2005-07-15 2009-01-15 タイコ ヘルスケア グループ リミテッド パートナーシップ Wound dressing and method of making and using the same
GB0526321D0 (en) * 2005-12-23 2006-02-01 Advanced Biotechnologies Inc Silicone composition
US20070258903A1 (en) * 2006-05-02 2007-11-08 Kleiner Lothar W Methods, compositions and devices for treating lesioned sites using bioabsorbable carriers
US20080051335A1 (en) * 2006-05-02 2008-02-28 Kleiner Lothar W Methods, compositions and devices for treating lesioned sites using bioabsorbable carriers
EP2316499B1 (en) * 2006-06-12 2013-05-01 Accentus Medical PLC Metal implants
GB0612028D0 (en) * 2006-06-16 2006-07-26 Imp Innovations Ltd Bioactive glass
WO2008017203A1 (en) * 2006-08-01 2008-02-14 Unilever Plc Biomaterials, their preparation and use
DE102006037497A1 (en) * 2006-08-10 2008-02-14 Friedrich-Baur Gmbh Porous solid with bimodal pore size distribution and process for its preparation
GB0616580D0 (en) * 2006-08-21 2006-09-27 Novathera Ltd Composite material
GB0616716D0 (en) * 2006-08-23 2006-10-04 Novathera Ltd Composite material
DE102006041023B4 (en) 2006-09-01 2014-06-12 Biocer Entwicklungs Gmbh Structured coatings for implants and process for their preparation
GB0618215D0 (en) * 2006-09-15 2006-10-25 Novathera Ltd Composite material
US20080119927A1 (en) * 2006-11-17 2008-05-22 Medtronic Vascular, Inc. Stent Coating Including Therapeutic Biodegradable Glass, and Method of Making
BRPI0720183B1 (en) * 2006-12-05 2019-03-26 Unilever N.V. PRODUCT FOR ORAL TREATMENT, PRODUCT UNDERSTANDING A FIRST COMPOSITION AND USE OF A FIRST COMPOSITION.
ATE477006T1 (en) * 2007-01-15 2010-08-15 Accentus Medical Plc METAL IMPLANTS
DE102007023294B4 (en) 2007-05-26 2012-08-23 Fachhochschule Kiel Method for producing an implant with an abrasion-resistant biotoxic coating
US20080299054A1 (en) * 2007-05-30 2008-12-04 Conopco, Inc., D/B/A Unilever Personal care compositions with enhanced fragrance delivery
GB0713094D0 (en) * 2007-07-05 2007-08-15 Imp Innovations Ltd Glass polycarboxylate cements
GB0714602D0 (en) * 2007-07-26 2007-09-05 Novathera Ltd Process
JP5287861B2 (en) 2007-10-03 2013-09-11 アクセンタス メディカル リミテッド Method for producing metal with biocidal properties
DE102007052519A1 (en) * 2007-10-29 2009-04-30 Aesculap Ag Medical implant
WO2009071537A2 (en) * 2007-12-04 2009-06-11 Basf Se Method for producing molded parts having reduced deposit formation
GB0724556D0 (en) * 2007-12-17 2008-01-30 Queen Mary & Westfield College LAtency associated protein construct with aggrecanase sensitive cleavage site
AU2015227489B2 (en) * 2008-02-29 2017-08-03 Smith & Nephew, Inc. Coating and Coating Method
JP5788179B2 (en) * 2008-02-29 2015-09-30 スミス アンド ネフュー インコーポレーテッド Coating and coating method
CN105688276A (en) * 2008-02-29 2016-06-22 史密夫和内修有限公司 Gradient coating for biomedical applications
EP2313027A1 (en) * 2008-05-27 2011-04-27 Imperial Innovations Limited Hypoxia inducing factor (hif) stabilising glasses
GB0809592D0 (en) * 2008-05-27 2008-07-02 Imp Innovations Ltd Biomaterials
US20090317339A1 (en) * 2008-06-23 2009-12-24 Deepak Sharma Teeth Bleaching Compositions and Devices
US20100030170A1 (en) * 2008-08-01 2010-02-04 Keith Alan Keller Absorptive Pad
DE102008052837A1 (en) * 2008-10-13 2010-04-15 Aesculap Ag Textile implant with core-shell construction and method for its production
EP2243749B1 (en) 2009-04-23 2015-04-08 PURAC Biochem BV Resorbable and biocompatible fibre glass compositions and their uses
ATE539778T1 (en) 2009-04-23 2012-01-15 Vivoxid Oy BIOCOMPATIBLE COMPOSITE AND ITS USE
GB0911365D0 (en) 2009-06-30 2009-08-12 Bioceramic Therapeutics Ltd Multicomponent glasses for use as coatings and in personal care products
US8845660B2 (en) * 2009-08-06 2014-09-30 Dsm Ip Assets B.V. Surgical repair article based on HPPE material
MX2012004919A (en) * 2009-10-29 2012-08-15 Prosidyan Inc Bone graft material.
EP2493425B1 (en) * 2009-10-29 2016-10-05 Prosidyan, Inc. Dynamic bioactive bone graft material and methods for handling
ES2672590T3 (en) * 2009-10-29 2018-06-15 Prosidyan, Inc. Dynamic bioactive bone graft material that has a designed porosity
GB2470088B (en) 2009-11-10 2011-06-29 Landmark Innovations Ltd Root canal therapy
US8778378B2 (en) 2009-12-21 2014-07-15 Orthovita, Inc. Bioactive antibacterial bone graft materials
US8173154B2 (en) * 2010-01-06 2012-05-08 The Curators Of The University Of Missouri Boron trioxide glass-based fibers and particles in dressings, sutures, surgical glue, and other wound care compositions
PL217617B1 (en) 2010-01-27 2014-08-29 Inst Chemii Przemysłowej Im Prof Ignacego Mościckiego Method of manufacturing silicon dioxide nanopowders with biociding properties, preferably for polymeric composites
US8425231B1 (en) 2012-01-23 2013-04-23 Mark N. Hochman Soft-tissue preservation temporary (shell) immediate-implant abutment method and device
US9452032B2 (en) 2012-01-23 2016-09-27 Biomet 3I, Llc Soft tissue preservation temporary (shell) immediate-implant abutment with biological active surface
US9089382B2 (en) 2012-01-23 2015-07-28 Biomet 3I, Llc Method and apparatus for recording spatial gingival soft tissue relationship to implant placement within alveolar bone for immediate-implant placement
US20130202670A1 (en) * 2012-02-03 2013-08-08 Orthovita, Inc. Bioactive antibacterial bone graft materials containing silver
SI24094B (en) 2012-06-15 2021-07-30 Institut "Jožef Stefan" Composites materials based on ceramic phase and metal with functionalized surface as environmentally-friendly materials with antibacterial activity, a process for preparing and use thereof
US20140031949A1 (en) * 2012-06-27 2014-01-30 Signal Medical Corporation Ceramic antibacterial
AU2013341718B2 (en) * 2012-09-18 2017-11-23 Novabone Products, Llc Bioglass with glycosaminoglycans
US8883195B2 (en) 2013-03-14 2014-11-11 Prosidyan, Inc. Bioactive porous bone graft implants
US8889178B2 (en) 2013-03-14 2014-11-18 Prosidyan, Inc Bioactive porous bone graft compositions in synthetic containment
US9381274B2 (en) 2013-03-14 2016-07-05 Prosidyan, Inc. Bone graft implants containing allograft
FR3006195B1 (en) 2013-06-03 2018-03-02 Centre National De La Recherche Scientifique IMPLANT WITH CONTROLLED POROSITY
CN104086171B (en) * 2014-07-14 2015-08-12 华振 A kind of netted sodium titanate biological ceramics and preparation method thereof
US9700390B2 (en) 2014-08-22 2017-07-11 Biomet 3I, Llc Soft-tissue preservation arrangement and method
FR3026309B1 (en) 2014-09-29 2017-11-24 Univ Blaise Pascal-Clermont-Ferrand Ii IMPLANT WITH VARIABLE POROSITY IN A HYBRID MATERIAL
JPWO2016093211A1 (en) * 2014-12-11 2017-09-21 日本電気硝子株式会社 Wound treatment glass composition, wound dressing and method for producing the same
WO2016144970A1 (en) 2015-03-09 2016-09-15 Chu Stephen J Gingival ovate pontic and methods of using the same
US10195305B2 (en) 2015-03-24 2019-02-05 Orthovita, Inc. Bioactive flowable wash-out resistant bone graft material and method for production thereof
GB201513040D0 (en) * 2015-07-23 2015-09-09 Ucl Business Plc Bone graft system
US11331191B2 (en) 2015-08-12 2022-05-17 Howmedica Osteonics Corp. Bioactive soft tissue implant and methods of manufacture and use thereof
CA2938576A1 (en) 2015-08-12 2017-02-12 Howmedica Osteonics Corp. Methods for forming scaffolds
EP3782658B1 (en) 2016-05-02 2024-04-10 Howmedica Osteonics Corp. Bioactive soft tissue implant and methods of manufacture and use thereof
FR3088550B1 (en) 2018-11-15 2021-02-26 Univ Clermont Auvergne CONTROLLED POROSITY IMPLANT IN A HYBRID MATERIAL DOPED IN OSTEOINDUCTIVE NUTRIENT
US11896612B2 (en) * 2019-03-29 2024-02-13 Board Of Trustees Of Michigan State University Resurrection of antibiotics that MRSA resists by silver-doped bioactive glass-ceramic particles
BG67373B1 (en) * 2019-08-23 2021-09-15 The Research Center for Advanced Materials Science King Khalid University (KKU) Composition of elastomeric biocomposite for insulating layers and substrates in flexible antennas
CN112300980A (en) * 2020-10-23 2021-02-02 紫水晶(海南)再生医学科技有限公司 Skin culture medium for skin grafting operation of bioactive glass material and preparation method thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001210A1 (en) * 1983-09-10 1985-03-28 The University Of Strathclyde Biodegradable implant
US5071674A (en) * 1989-11-30 1991-12-10 The University Of Florida Method for producing large silica sol-gels doped with inorganic and organic compounds
JPH05213621A (en) * 1992-01-31 1993-08-24 Tokuyama Soda Co Ltd Production of silver-containing glass
WO1994004657A1 (en) * 1992-08-13 1994-03-03 The Trustees Of The University Of Pennsylvania Bioactive material template for in vitro synthesis of bone tissue
JPH09110463A (en) * 1995-10-06 1997-04-28 Ion Kogaku Shinko Zaidan Antibacterial glass and its production
US5834008A (en) * 1996-09-19 1998-11-10 U.S. Biomaterials Corp. Composition and method for acceleration of wound and burn healing
WO1999007777A1 (en) * 1997-08-08 1999-02-18 Us Biomaterials Corporation Biologically active glass-based substrate
US5874101A (en) * 1997-04-14 1999-02-23 Usbiomaterials Corp. Bioactive-gel compositions and methods

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1418019A (en) * 1972-12-11 1975-12-17 Paterson Zochonis Co Ltd Antimicrobial compositions
US4103002A (en) 1977-02-08 1978-07-25 Board Of Regents, University Of Florida Bioglass coated A1203 ceramics
US4303066A (en) 1979-06-28 1981-12-01 National Patent Development Corporation Burn dressing
US4272518A (en) 1979-07-10 1981-06-09 Moro Daniel G Plastic wound bandage
US5017627A (en) 1980-10-09 1991-05-21 National Research Development Corporation Composite material for use in orthopaedics
DE3270438D1 (en) 1981-09-30 1986-05-15 Leipzig Arzneimittel Absorbent wound dressing and processes for its production
US4538603A (en) 1982-04-22 1985-09-03 E. R. Squibb & Sons, Inc. Dressings, granules, and their use in treating wounds
ES8507345A1 (en) 1982-12-02 1985-09-01 Wallone Region Bioreactive materials
US4539200A (en) 1983-11-04 1985-09-03 The Kendall Company Treatment of skin lesions
GB2150833B (en) 1983-12-08 1987-04-15 Ceskoslovenska Akademie Ved Proteolytic wounds dressing
US4837285A (en) 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
US4851046A (en) 1985-06-19 1989-07-25 University Of Florida Periodontal osseous defect repair
JPH0715670B2 (en) 1985-07-19 1995-02-22 ヤマハ株式会社 Data processing device
US5263992A (en) 1986-10-17 1993-11-23 Bio-Metric Systems, Inc. Biocompatible device with covalently bonded biocompatible agent
DE3726617C1 (en) 1987-08-11 1988-07-07 Friedrichsfeld Gmbh Wound covering
US5126141A (en) 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5470585A (en) * 1989-01-27 1995-11-28 Giltech Limited Medicinal substance for topical application
US5330770A (en) * 1989-03-11 1994-07-19 Kinki Pipe Giken Kabushiki Kaisha Water-soluble glass water-treating agent
JPH0629126B2 (en) 1989-03-29 1994-04-20 京都大学長 Coating method of bioactive hydroxyapatite film
US5298260A (en) 1990-05-01 1994-03-29 Mediventures, Inc. Topical drug delivery with polyoxyalkylene polymer thermoreversible gels adjustable for pH and osmolality
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5340776A (en) 1991-01-11 1994-08-23 Schott Glaswerke Preparation of very fine glass powder of high purity
JP3057773B2 (en) 1991-02-05 2000-07-04 不二製油株式会社 Pie making method
US5766611A (en) 1991-02-22 1998-06-16 Ishizuka Garasu Kabushiki Kaisha Cosmetic products containing a soluble glass
ES2167330T3 (en) 1992-02-28 2002-05-16 Cohesion Tech Inc INJECTABLE CERAMIC COMPOSITIONS AND ITS PREPARATION AND USE PROCEDURE.
US5696169A (en) 1992-03-13 1997-12-09 Otsuka Pharmaceutical Co., Ltd. Antibacterial and antifungal activity method, therapeutic method of infectious diseases and preserving method of cosmetics
US5681575A (en) 1992-05-19 1997-10-28 Westaim Technologies Inc. Anti-microbial coating for medical devices
US5807641A (en) 1993-05-31 1998-09-15 Sumitomo Osaka Cement Co., Ltd. Anti-bacterial and anti-fungal glaze composition for ceramic products
IL110787A0 (en) 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
US5536614A (en) 1994-04-21 1996-07-16 Nec Corporation Method for manufacturing a nonmagnetic single-component developer
JP3486951B2 (en) * 1994-05-09 2004-01-13 日本板硝子株式会社 Antibacterial glass composition
JP3021287B2 (en) * 1994-07-01 2000-03-15 石塚硝子株式会社 Antibacterial agent for sandbox
US5591453A (en) 1994-07-27 1997-01-07 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
US5501706A (en) 1994-11-29 1996-03-26 Wildflower Communications, Inc. Medical implant structure and method for using the same
US5728753A (en) 1995-11-09 1998-03-17 University Of London Bioactive composite material for repair of hard and soft tissues
US5681872A (en) * 1995-12-07 1997-10-28 Orthovita, Inc. Bioactive load bearing bone graft compositions
CN1103750C (en) 1996-01-29 2003-03-26 巴尔的摩的马里兰大学 Bioactive glass compositions and methods of treatment using bioactive glass
JPH09301743A (en) * 1996-05-10 1997-11-25 Nippon Sheet Glass Co Ltd Colored film coated glass article
US5840290A (en) 1996-05-30 1998-11-24 University Of Florida Research Foundation Injectable bio-active glass in a dextran suspension
WO1999013582A1 (en) 1997-09-09 1999-03-18 Advanced Fibre Communications, Inc. Perturbation tolerant digital phase-locked loop employing phase-frequency detector
US5990380A (en) 1997-10-10 1999-11-23 University Of Florida Research Foundation, Inc. Percutaneous biofixed medical implants
US6228788B1 (en) * 1998-08-21 2001-05-08 Advanced Ceramic X Corporation High-frequency ceramic inductor formulation
JP2002543108A (en) 1999-04-29 2002-12-17 ユーエスバイオマテリアルズ コーポレイション Anti-inflammatory bioactive glass particles

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001210A1 (en) * 1983-09-10 1985-03-28 The University Of Strathclyde Biodegradable implant
US5071674A (en) * 1989-11-30 1991-12-10 The University Of Florida Method for producing large silica sol-gels doped with inorganic and organic compounds
JPH05213621A (en) * 1992-01-31 1993-08-24 Tokuyama Soda Co Ltd Production of silver-containing glass
WO1994004657A1 (en) * 1992-08-13 1994-03-03 The Trustees Of The University Of Pennsylvania Bioactive material template for in vitro synthesis of bone tissue
JPH09110463A (en) * 1995-10-06 1997-04-28 Ion Kogaku Shinko Zaidan Antibacterial glass and its production
US5834008A (en) * 1996-09-19 1998-11-10 U.S. Biomaterials Corp. Composition and method for acceleration of wound and burn healing
US5874101A (en) * 1997-04-14 1999-02-23 Usbiomaterials Corp. Bioactive-gel compositions and methods
WO1999007777A1 (en) * 1997-08-08 1999-02-18 Us Biomaterials Corporation Biologically active glass-based substrate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 017, no. 659 (C - 1137) 7 December 1993 (1993-12-07) *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 08 29 August 1997 (1997-08-29) *

Also Published As

Publication number Publication date
US6482444B1 (en) 2002-11-19
CA2377402A1 (en) 2000-12-21
DE60022197D1 (en) 2005-09-29
CA2377402C (en) 2011-01-18
PT1196150E (en) 2005-11-30
DK1196150T3 (en) 2005-11-21
AU5485200A (en) 2001-01-02
EP1196150A1 (en) 2002-04-17
ES2245644T3 (en) 2006-01-16
EP1196150B1 (en) 2005-08-24
ATE302621T1 (en) 2005-09-15
DE60022197T2 (en) 2006-03-23
WO2000076486A1 (en) 2000-12-21

Similar Documents

Publication Publication Date Title
EP1196150A4 (en) Silver-containing, sol-gel derived bioglass compositions
Balasubramanian et al. Boron-containing bioactive glasses in bone and soft tissue engineering
Kargozar et al. Strontium-and cobalt-substituted bioactive glasses seeded with human umbilical cord perivascular cells to promote bone regeneration via enhanced osteogenic and angiogenic activities
Li et al. Valence state manipulation of cerium oxide nanoparticles on a titanium surface for modulating cell fate and bone formation
Miranda et al. Three-dimensional culture of rat BMMSCs in a porous chitosan-gelatin scaffold: A promising association for bone tissue engineering in oral reconstruction
Kawashita et al. Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid
Balasubramanian et al. Ion release, hydroxyapatite conversion, and cytotoxicity of boron‐containing bioactive glass scaffolds
Martins et al. Responsive and in situ-forming chitosan scaffolds for bone tissue engineering applications: an overview of the last decade
Rau et al. Bioactive materials for bone tissue engineering
Mouriño et al. Enhancing biological activity of bioactive glass scaffolds by inorganic ion delivery for bone tissue engineering
EP2258413A1 (en) Multi-dimensional biomaterial and method for producing the same.
AU3155700A (en) New biomaterials
Shi et al. β-TCP scaffold coated with PCL as biodegradable materials for dental applications
Abodunrin et al. A review on borate bioactive glasses (BBG): effect of doping elements, degradation, and applications
Fernandes et al. Intrinsic antibacterial borosilicate glasses for bone tissue engineering applications
Lim et al. The effects of silver, silicon-containing apatite towards bacteria and cell responses
Wang et al. Simultaneous enhancement of vascularization and contact-active antibacterial activity in diopside-based ceramic orbital implants
WO2015140088A1 (en) Implantable paste and its use
Coathup et al. A comparison of allogeneic and autologous mesenchymal stromal cells and osteoprogenitor cells in augmenting bone formation around massive bone tumor prostheses
Saxena et al. Calcium phosphate enriched synthetic tyrosine-derived polycarbonate–dicalcium phosphate dihydrate polymer scaffolds for enhanced bone regeneration
Van Blitterswijk et al. The biological performance of calcium phosphate ceramics in an infected implantation site: I. Biological performance of hydroxyapatite during Staphylococcus aureus infection
Abushahba et al. Air abrasion with bioactive glass eradicates Streptococcus mutans biofilm from a sandblasted and acid-etched titanium surface
Sergeeva et al. Scleractinium coral aquaculture skeleton: A possible 3D scaffold for cell cultures and bone tissue engineering
Xu et al. Osteo-angiogenic and antibacterial activity of a multifunctional micro-porous coating on zirconium alloy
Wu et al. In vivo and in vitro evaluation of chitosan-modified bioactive glass paste for wound healing

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020109

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

A4 Supplementary search report drawn up and despatched

Effective date: 20021113

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61L 27/10 A, 7A 61K 9/70 B, 7A 61L 17/00 B, 7A 61L 27/30 B, 7A 61L 27/54 B, 7A 61L 15/42 B, 7A 61L 15/44 B, 7C 03C 4/00 B

17Q First examination report despatched

Effective date: 20030414

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 60022197

Country of ref document: DE

Date of ref document: 20050929

Kind code of ref document: P

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: MICHELI & CIE INGENIEURS-CONSEILS

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20050403078

Country of ref document: GR

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2245644

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20060526

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CY

Payment date: 20070529

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20080614

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20110609

Year of fee payment: 12

Ref country code: IE

Payment date: 20110621

Year of fee payment: 12

Ref country code: GR

Payment date: 20110624

Year of fee payment: 12

Ref country code: SE

Payment date: 20110622

Year of fee payment: 12

Ref country code: MC

Payment date: 20110622

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20110629

Year of fee payment: 12

Ref country code: LU

Payment date: 20110708

Year of fee payment: 12

Ref country code: AT

Payment date: 20110622

Year of fee payment: 12

Ref country code: FI

Payment date: 20110622

Year of fee payment: 12

Ref country code: DK

Payment date: 20110620

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20110624

Year of fee payment: 12

REG Reference to a national code

Ref country code: PT

Ref legal event code: MM4A

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20121214

BERE Be: lapsed

Owner name: *IMPERIAL COLLEGE INNOVATIONS

Effective date: 20120630

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20130101

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120614

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120630

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 302621

Country of ref document: AT

Kind code of ref document: T

Effective date: 20120614

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121214

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120615

REG Reference to a national code

Ref country code: GR

Ref legal event code: ML

Ref document number: 20050403078

Country of ref document: GR

Effective date: 20130104

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120614

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130101

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130104

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120614

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120702

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120614

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20170621

Year of fee payment: 18

Ref country code: CH

Payment date: 20170620

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20170626

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20170724

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20180620

Year of fee payment: 19

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 60022197

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180614

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190101

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20190916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180615

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20190614

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190614