EP1095011A4 - Novel fluorescent lanthanide chelates - Google Patents
Novel fluorescent lanthanide chelatesInfo
- Publication number
- EP1095011A4 EP1095011A4 EP99932334A EP99932334A EP1095011A4 EP 1095011 A4 EP1095011 A4 EP 1095011A4 EP 99932334 A EP99932334 A EP 99932334A EP 99932334 A EP99932334 A EP 99932334A EP 1095011 A4 EP1095011 A4 EP 1095011A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- novel fluorescent
- lanthanide chelates
- fluorescent lanthanide
- chelates
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052747 lanthanoid Inorganic materials 0.000 title 1
- 150000002602 lanthanoids Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0026—Acridine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9194498P | 1998-07-07 | 1998-07-07 | |
| US91944P | 1998-07-07 | ||
| PCT/US1999/015366 WO2000001663A1 (en) | 1998-07-07 | 1999-07-07 | Novel fluorescent lanthanide chelates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1095011A1 EP1095011A1 (en) | 2001-05-02 |
| EP1095011A4 true EP1095011A4 (en) | 2003-01-08 |
Family
ID=22230424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP99932334A Withdrawn EP1095011A4 (en) | 1998-07-07 | 1999-07-07 | Novel fluorescent lanthanide chelates |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1095011A4 (en) |
| JP (1) | JP2002519404A (en) |
| CA (1) | CA2336904A1 (en) |
| WO (1) | WO2000001663A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440389B1 (en) * | 2000-07-19 | 2002-08-27 | The General Hospital Corporation | Fluorescent agents for real-time measurement of organ function |
| EP1337536B1 (en) * | 2000-10-19 | 2012-09-12 | ExxonMobil Chemical Patents Inc. | Cationic group-3 catalyst system |
| DE10163295B4 (en) * | 2001-12-21 | 2004-03-25 | Honeywell Specialty Chemicals Seelze Gmbh | Rare earth metal compounds and mixtures thereof, processes for their preparation and their use |
| DE102004022628A1 (en) * | 2004-05-07 | 2005-12-15 | Sensient Imaging Technologies Gmbh | FRET bioassay |
| DE102004024011A1 (en) * | 2004-05-14 | 2005-12-01 | Bayer Chemicals Ag | Difluoro-1,3-dioxole |
| CA2573869A1 (en) * | 2004-07-23 | 2006-02-09 | Amgen Inc. | Generic probes for the detection of phosphorylated sequences |
| CA2578030A1 (en) * | 2004-08-26 | 2006-03-09 | Mallinckrodt Inc. | Luminescent metal complexes for monitoring renal function |
| US8193174B2 (en) | 2005-05-11 | 2012-06-05 | University Of Durham | Responsive luminescent lanthanide complexes |
| WO2006120444A1 (en) * | 2005-05-11 | 2006-11-16 | University Of Durham | Responsive luminescent lanthanide complexes |
| EP1886685A1 (en) | 2006-08-11 | 2008-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition |
| GB2451106A (en) * | 2007-07-18 | 2009-01-21 | Cis Bio Int | Lanthanide (III) ion complexing pyrazoyl-aza(thio)xanthone comprising compounds, their complexes and their use as fluorescent labels |
| BR112012008381A2 (en) | 2009-09-24 | 2017-06-13 | Inserm (Institut Nat De La Santé Et De La Rech Médicale) | fkbp52-tau interaction as a new therapeutic target to treat neurological disorders involving tau dysfunction |
| HUE045270T2 (en) | 2010-01-05 | 2019-12-30 | Inst Nat Sante Rech Med | Flt3 receptor antagonists for the treatment or the prevention of pain disorders |
| DE102011001368B4 (en) | 2011-03-17 | 2013-01-31 | Bundesanstalt für Materialforschung und -Prüfung (BAM) | Lanthanoid chelates containing particles, their preparation and their use in bioanalysis |
| DE102011101207B3 (en) * | 2011-05-11 | 2012-05-10 | Sartorius Stedim Biotech Gmbh | Fluorescent dye for pH sensor |
| EP2710381A2 (en) | 2011-05-16 | 2014-03-26 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for screening substances capable of modulating the replication of an influenza virus |
| WO2014053871A1 (en) | 2012-10-04 | 2014-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for screening a compound capable of inhibiting the notch1 transcriptional activity |
| JP6666848B2 (en) | 2014-02-18 | 2020-03-18 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Methods and pharmaceutical compositions for the treatment of diseases mediated by the NRP-1 / OBR complex signaling pathway |
| US10189887B2 (en) | 2014-04-17 | 2019-01-29 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Polypeptides and uses thereof for reducing CD95-mediated cell motility |
| WO2020144324A1 (en) | 2019-01-11 | 2020-07-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for screening inhibitors against chikungunya virus and for determining whether subjects are predisposed to infection by said virus |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162508A (en) * | 1987-12-18 | 1992-11-10 | Compagnie Oris Industrie | Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers |
| WO1996000901A1 (en) * | 1994-06-29 | 1996-01-11 | The Regents Of The University Of California | Luminescent lanthanide chelates and methods of use |
| DE19505960A1 (en) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Conjugate for the individual dosage of drugs |
| WO1999066780A2 (en) * | 1998-06-25 | 1999-12-29 | Smithkline Beecham Plc | Cinoxacin lanthanide chelates and their use as biomolecular probes |
-
1999
- 1999-07-07 EP EP99932334A patent/EP1095011A4/en not_active Withdrawn
- 1999-07-07 JP JP2000558068A patent/JP2002519404A/en active Pending
- 1999-07-07 WO PCT/US1999/015366 patent/WO2000001663A1/en not_active Application Discontinuation
- 1999-07-07 CA CA002336904A patent/CA2336904A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162508A (en) * | 1987-12-18 | 1992-11-10 | Compagnie Oris Industrie | Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers |
| WO1996000901A1 (en) * | 1994-06-29 | 1996-01-11 | The Regents Of The University Of California | Luminescent lanthanide chelates and methods of use |
| DE19505960A1 (en) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Conjugate for the individual dosage of drugs |
| WO1999066780A2 (en) * | 1998-06-25 | 1999-12-29 | Smithkline Beecham Plc | Cinoxacin lanthanide chelates and their use as biomolecular probes |
Non-Patent Citations (4)
| Title |
|---|
| BAILEY, M.PHILIP ET AL., ANALYST, vol. 110, 1985, pages 603 - 604, XP001040544 * |
| DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002219212, retrieved from STN Database accession no. 127:77478/DN, HCAPLUS * |
| OZAKI, H. ET AL., KIDORUI, vol. 30, 1997, pages 358 - 359 * |
| See also references of WO0001663A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2336904A1 (en) | 2000-01-13 |
| WO2000001663A1 (en) | 2000-01-13 |
| EP1095011A1 (en) | 2001-05-02 |
| JP2002519404A (en) | 2002-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20010202 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20021126 |
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| AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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| 17Q | First examination report despatched |
Effective date: 20031112 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20060822 |