EP1039914A4 - Cyclooxygenase-2 inhibition - Google Patents
Cyclooxygenase-2 inhibitionInfo
- Publication number
- EP1039914A4 EP1039914A4 EP98961802A EP98961802A EP1039914A4 EP 1039914 A4 EP1039914 A4 EP 1039914A4 EP 98961802 A EP98961802 A EP 98961802A EP 98961802 A EP98961802 A EP 98961802A EP 1039914 A4 EP1039914 A4 EP 1039914A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cyclooxygenase
- inhibition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6995597P | 1997-12-17 | 1997-12-17 | |
US69955P | 1997-12-17 | ||
PCT/US1998/025206 WO1999030721A1 (en) | 1997-12-17 | 1998-12-07 | Cyclooxygenase-2 inhibition |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1039914A1 EP1039914A1 (en) | 2000-10-04 |
EP1039914A4 true EP1039914A4 (en) | 2007-06-27 |
Family
ID=22092236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98961802A Withdrawn EP1039914A4 (en) | 1997-12-17 | 1998-12-07 | Cyclooxygenase-2 inhibition |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1039914A4 (en) |
AU (1) | AU1703799A (en) |
CA (1) | CA2313049A1 (en) |
WO (1) | WO1999030721A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6403630B1 (en) * | 1999-01-27 | 2002-06-11 | Cornell Research Foundation, Inc. | Treating cancers associated with overexpression of HER-2/neu |
EP1194141B1 (en) * | 1999-07-02 | 2005-08-17 | Universitair Medisch Centrum Utrecht | Antiviral therapy |
US6787573B2 (en) | 1999-07-02 | 2004-09-07 | Universiteit Utrecht | Antiviral therapy |
EP1064940A1 (en) * | 1999-07-02 | 2001-01-03 | Universitair Medisch Centrum Utrecht | Antiviral therapy |
ATE270886T1 (en) * | 2000-03-17 | 2004-07-15 | Univ Utrecht | ANTIVIRAL THERAPY |
RU2004121147A (en) * | 2002-01-10 | 2005-04-10 | Фармация Энд Апджон Компани (Us) | APPLICATION OF SOX-2 INHIBITORS IN COMBINATION WITH ANTIVIRAL AGENTS FOR TREATMENT OF INFECTION OF PAPILLOMA VIRUS |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
DE112012003457T5 (en) | 2011-10-21 | 2015-03-12 | Abbvie Inc. | Combination treatment (e.g., with ABT-072 or ABT-333 from DAAs for use in the treatment of HCV) |
EA201490837A1 (en) | 2011-10-21 | 2014-11-28 | Эббви Инк. | METHODS OF TREATING HCV, INCLUDING, AT THE LITERATURE, TWO ANTI-VIRAL AGENTS OF DIRECT ACTION, RIBAVIRIN, BUT NOT INTERFERON |
EA201892448A1 (en) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | ALKYN-CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND RELATED APPLICATION METHODS |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5436265A (en) * | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
WO1997029775A1 (en) * | 1996-02-13 | 1997-08-21 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist |
WO1997029776A1 (en) * | 1996-02-13 | 1997-08-21 | G.D. Searle & Co. | Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
WO1996039144A1 (en) * | 1995-06-06 | 1996-12-12 | Procyte Corporation | Stable copper(i) complexes as active therapeutic substances |
-
1998
- 1998-12-07 CA CA002313049A patent/CA2313049A1/en not_active Abandoned
- 1998-12-07 WO PCT/US1998/025206 patent/WO1999030721A1/en active Application Filing
- 1998-12-07 AU AU17037/99A patent/AU1703799A/en not_active Abandoned
- 1998-12-07 EP EP98961802A patent/EP1039914A4/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5436265A (en) * | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
WO1997029775A1 (en) * | 1996-02-13 | 1997-08-21 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist |
WO1997029776A1 (en) * | 1996-02-13 | 1997-08-21 | G.D. Searle & Co. | Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors |
Non-Patent Citations (6)
Title |
---|
ANDREONE P ET AL: "INDOMETHACIN ENHANCES SERUM 2'5'-OLIGOADENYLATE SYNTHETASE IN PATIENTS WITH HEPATITIS B AND C VIRUS CHRONIC ACTIVE HEPATITIS", JOURNAL OF HEPATOLOGY, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 21, no. 6, 1994, pages 984 - 988, XP009042789, ISSN: 0168-8278 * |
ANDREONE P ET AL: "Indomethacin increases 2',5'-oligoadenylate synthetase release by cultured liver tissue of patients with HCV chronic active hepatitis", INTERNATIONAL HEPATOLOGY COMMUNICATIONS 1994 NETHERLANDS, vol. 2, no. 5, 1994, pages 289 - 294, XP002422459, ISSN: 0928-4346 * |
ANDREONE P ET AL: "Interferon-[alpha] plus indomethacin combined therapy in HBeAg positive chronic hepatitis B non-responder to a previous IFN[alpha] course: Results of a pilot study", INTERNATIONAL HEPATOLOGY COMMUNICATIONS, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 5, no. 3, 1996, pages 151 - 159, XP002313973, ISSN: 0928-4346 * |
HEINRICH D ET AL: "Treatment of chronic viral hepatitis with acetylsalicylic acid", SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT, vol. 125, no. 15, 1995, pages 755 - 757, XP008075508, ISSN: 0036-7672 * |
NANJI AMIN A ET AL: "Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat", GASTROENTEROLOGY, vol. 112, no. 3, 1997, pages 943 - 951, XP002422458, ISSN: 0016-5085 * |
See also references of WO9930721A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999030721A1 (en) | 1999-06-24 |
EP1039914A1 (en) | 2000-10-04 |
AU1703799A (en) | 1999-07-05 |
CA2313049A1 (en) | 1999-06-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000714 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RAP3 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: CORNELL RESEARCH FOUNDATION, INC. |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 263/32 20060101ALI20070312BHEP Ipc: C07D 231/12 20060101ALI20070312BHEP Ipc: A61K 31/42 20060101ALI20070312BHEP Ipc: A61K 31/415 20060101ALI20070312BHEP Ipc: A61K 31/365 20060101AFI20070312BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20070530 |
|
17Q | First examination report despatched |
Effective date: 20071002 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20100930 |