EP0999432A2 - Method of operating an electronic dosing system and dosing system for carrying out the method - Google Patents

Abstract

The method involves reading or writing device-specific parameters or user parameters or routines for operating processes or a program or at least part of a program in to a read-write memory (20). The hand dosing device (42) may be remotely operated. The hand dosing device (42) has a drive device (1) with an electric drive (7) and at least one displacement device (2) that can be driven by the drive device to dose fluid. A software-driven electronic control unit (3) operates the drive device and has at least one non-volatile read-write memory (20). An electric power supply (29) is provided for the electric drive and the control unit. A data interface (17) connected to the control unit has a data processor and a data transfer device, which has a data interface to connect the data interface of the dosing device to the data processor. An Independent claim is included for a dosing system.

Description

The invention relates to a method for operating an electronic Dosing system with an electronic hand dosing device and on a dosing system to carry out the method.

Electronic dosing devices are used in dosing laboratories of liquids. They are in different designs known. Have dosing devices working according to the air cushion principle an integrated piston-cylinder unit, by means of which an air column can be moved is to suck in and out of sample liquid in a dosing tip to expel this. The piston-cylinder unit does not come into play here Contact with the liquid. Only the dosing tip, which is usually made up Plastic is contaminated and can be replaced after use become.

With direct displacement dosing devices, however, a syringe becomes direct filled with sample liquid. So the pistons and cylinders of the syringe contaminated by the liquid so that the syringe before changing the Liquid is usually replaced or cleaned with a new syringe got to. The syringe is also usually made of plastic.

Pistonless metering devices can be a metering tip with a balloon-like Have end portion that for sucking liquid is expanded and compressed to eject. Such dosing tips are has also been designed as an exchange part.

Microdosing devices can be a micromembrane pump and / or have a free jet dispenser, at least one of these components microsystem technology, especially in silicon, glass, Plastic injection molding and / or plastic stamping technology. The dosage will achieved by deforming a wall of a chamber with liquid is filled. The electrical drive for deforming the wall can be piezoelectric, thermoelectric, electromagnetic, electrostatic, electromechanical, be magneto-restrictive etc.

Air cushion, direct displacement, pistonless and microdosing devices can have an unchangeable or a variable dosing volume. A change in the dosing volume is done by adjusting the displacement reached the displacement device, d. H. of the displacement path the piston or the degree of deformation of the balloon-like end section or the chamber wall.

Dispensers are dosing devices that contain an absorbed volume of liquid can deliver repetitively in small portions.

Kanäle" aufweisen, mittels derer gleichzeitig dosiert wird.There are also multi-channel dosing devices that have several

Have channels ", by means of which dosing is carried out simultaneously.

All dosing devices can be designed as hand-held devices.

All of the aforementioned metering devices can be electronic metering devices an electronic dosing system in the sense of this application. They have a drive device with an electric drive to drive the displacement device. They also have one electronic control and / or regulating device, in particular for the Drive, which is an electric drive motor, an electric linear drive or one of those mentioned in connection with microdosing devices Can be drives. They also have an electrical voltage source to supply control and / or regulating device and drive, the can be rechargeable. Electronic dosing devices have the advantage the high reproducibility of doses. Especially through preset ones Dosing speeds (µl / s) can achieve more precise results are considered to be with manually powered devices. You can also use the The advantage of multifunctionality is that they have pipetting, dispensing, titration, Can perform mixed etc. functions.

The well-known Response® electronic handheld dispensers Applicants work according to the air cushion principle and are available in single-channel or multi-channel versions. Four models cover the Dosing range from 0.5 µl to 5 ml. This metering device can be in different Operating modes, including pipette and dispense. The Dispensing is possible in up to 25 steps. The user can choose between three different dosing speeds. The dosing device can be used to charge the battery cells in a charging station.

From EP 0 864 364 A2 there is a similar electronic manual dosing device with rechargeable batteries and a charging station for charging them known. The hand dosing device can be in different Operating modes are operated that, apart from pipetting and dispensing include a hands-free operation. In it the hair dosing device is like this programmed to suck, dispense and time delays controls to replace or treat the dosing tip. She leads this Program steps over a predetermined number of cycles.

The previously known electronic manual dosing devices have the Disadvantage that the specific operating parameters (e.g. step sizes of the Piston feeds, dosing speeds, state of charge criteria, display outputs) and the program are fixed. The electronic Control device namely comprises a microcomputer which is fixed after one stored program works in which these parameters are contained. Special software is therefore required for each model and one Subsequent changes to the parameters are hardly possible. It is also disadvantageous that the programming of the hands-free operation is laborious over the Keyboard of the hand dosing device must be done and that in free-hand operation the programmed steps are rigidly processed and the The operational sequence cannot be influenced.

Dosing devices are test equipment in the sense of the GLP (Good Laboratory Practice) guidelines and comparable QS standards (ISO 9000 ff, EN 45000 ff). According to the GLP guidelines, the published by the manufacturer Error limits are checked at regular intervals. The applicant has disclosed a system with which the Calibration of dosing devices quickly, conveniently and inexpensively accomplish.

This system is based on a PICASO® calibration software that works on a PC is running. In addition, you need a measuring set-up, the weighing vessels, Adapters and carrier sleeves as well as an evaporation trap and one Semi-microbalance included. In the software all relevant data of the testing dosing devices. Deviations from these target values are immediately after transfer of the weighing values to the computer determined. A series of measurements comprises up to 15 individual weighings. From that become Average, inaccuracy, imprecision and standard deviation determined and compared with predetermined target values. All measurement and reference data can be logged in accordance with GLP-DIN.

During calibration, the control panel of the electronic hand-held dosing device entered the dosing data and controlled their operation. The weighing values are typed into the PC. This is tedious and can be too Make mistakes.

Proceeding from this, the object of the invention is a method to operate an electronic dosing system in which the Influenceability of operating parameters, operating procedures, program parts or entire programs is improved. In addition, advantageous Dosing systems provided for performing the method become.

A method that solves the problem is specified in claim 1. Configurations the same and advantageous dosing systems for its implementation are the subject of the following claims.

• einer elektronischen Handdosiervorrichtung, die
• eine einen elektrischen Antrieb aufweisende Antriebseinrichtung,
• mindestens eine von der Antriebseinrichtung antreibbare Verdrängungseinrichtung zum Dosieren von Flüssigkeit,
• eine programmgesteuerte elektronische Steuer- und/oder Regeleinrichtung insbesondere für den Antrieb,
• mindestens einen nicht-flüchtigen Schreib-Lese-Speicher
• eine elektrische Spannungsquelle insbesondere für den elektrischen Antrieb und die elektronischen Steuer- und/oder Regeleinrichtung und
• eine mit der elektronischen Steuer- und/oder Regeleinrichtung verbundene Datenschnittstelle aufweist,
  mit
• einer Datenverarbeitungsanlage,
  und mit
• einer Datentransfereinrichtung, die
• eine Datenschnittstelle zum Verbinden der Datenschnittstelle der Dosiervorrichtung mit der Datenverarbeitungsanlage aufweist,
  wobei mittels der Datenverarbeitungsanlage über die Datenschnittstellen
• gerätetypspezifische und/oder gerätespezifische Parameter und/oder
• Anwenderparameter und/oder
• Routinen für die Durchführung von Betriebsabläufen und/oder
• das Programm und/oder mindestens ein Programmteil
  in den Schreib-Lese-Speicher einschreibbar und/oder aus diesem auslesbar sind und/oder
• die Handdosiervorrichtung fernsteuerbar ist.

The object is achieved by a method for operating an electronic dosing system

• an electronic hand dosing device that
• a drive device having an electric drive,
• at least one displacement device which can be driven by the drive device for metering liquid,
• a program-controlled electronic control and / or regulating device, in particular for the drive,
• at least one non-volatile read-write memory
• an electrical voltage source, in particular for the electrical drive and the electronic control and / or regulating device and
• has a data interface connected to the electronic control and / or regulating device,
  With
• a data processing system,
  and with
• a data transfer device, the
• has a data interface for connecting the data interface of the metering device to the data processing system,
  whereby by means of the data processing system via the data interfaces
• device-specific and / or device-specific parameters and / or
• User parameters and / or
• Routines for performing operations and / or
• the program and / or at least one part of the program
  can be written into and / or read from the read / write memory and / or
• the hand dosing device is remotely controllable.

According to the invention, the external data processing system can therefore be used access to the read-write memory of the manual dosing device become. This opens up the possibility of changing operating parameters, to which the program-controlled electronic control and / or regulating device falls back on when carrying out operations.

These can be device-specific parameters, in particular those that are intended for the execution of operating processes. For example, these can be parameters determining the movement of the piston of a displacement device (e.g. acceleration characteristic, piston speed, driving force, holding torque). Furthermore, these can be, for example, quantity-determining parameters (e.g. basic values and limit values for dosing quantities, possible numbers of dosing steps, excess stroke volume for ejecting residual liquid). Other device-specific parameters can relate in particular to the monitoring of operating states (e.g. evaluation criteria for the state of charge of an accumulator, for the actuation of a limit switch or for the duration of a break for the purpose of switching off in one Device-specific parameters can in particular be an identification of the device, an identification code for a parameter set stored in each case, etc.

User parameters are data that the user can manually enter via a Keyboard of the handheld dosing device can be entered. For this include in particular the dosing volume, dosing speeds etc. Further application parameters concern the calibration of the hand dosing device. In a simple case, this can be a correction factor to convert the set dosing quantities to the actual act dispensed quantities. In particular, this can also Coefficients of a function, which is the deviation of the set from the actual dispensed quantities with different quantity settings includes.

Furthermore, the invention opens up the possibility of using the external data processing system to place routines for carrying out operational processes in the read / write memory of the hand-held metering device so that the program-controlled electronic control and / or regulating device accesses them. These routines can be created by the user and are used to control operational sequences composed of several operating processes, especially if these have to be repeated. For example, such Short programs "control the intake, mixing and dispensing of certain quantities of liquid or a dilution series in which the dispensed volume is halved from dilution step to dilution step. This simplifies the use of routines for the user. There is also the possibility of storing routines stored in the data processing system Hand over metering device.

Furthermore, the program can be done by means of the external data processing system the program-controlled electronic control and / or regulating device or at least a part of it is written into the read-write memory and / or read from it. That's what memory is for preferably a flash memory of a processor. A processor with flash memory has implemented a program provided by the manufacturer that initiate communication for data exchange via an interface can. This makes it possible to partially in each hand dosing device or completely different program from the outside via the data interfaces import or change the program in whole or in part.

In addition, a remote control is possible using the external data processing system the manual dosing device possible. This favors in particular the calibration by the respective dosing data by means of the data processing system transferred to the hand dosing device and if necessary even their operation entirely by means of the data processing system is controlled. In addition, the data processing system can each Log dosing data. If necessary, this can be done together with the respective measured values happen, if these are recorded and in the data processing system be imported. In addition, by means of the data processing system a wired or wireless remote control of the Hand dosing device. This favors automation in particular the dosing processes, the use of the hand dosing device in a higher-level automation process or safe dosing in a contaminated environment.

The invention thus enables the specific parameters of the metering device to be determined only after the device has been installed, even if this is the Includes installation of a module with permanently programmed software. This makes it possible to use the same for different device models Use software and electronics hardware. The respective Parameters can be set or even changed as needed. In Extension of this idea is even a device-specific or device-specific definition or change of program parts or the entire program possible. Due to the fact that user parameters can be saved by means of an external data processing system additional, advantageous operating possibility created. Also favors the Invention an automation of calibration and final inspection in manufacturing. The service will receive an easy update to new operating parameters enables. The OEM customer can in turn set parameters for Carry out special OEM dosing parts. The GLP parameter documentation is available to the user facilitated and a simplified calibration with PC software. He will also be involved in automation processes facilitated and enables remote control.

The data interfaces of the hand dosing device and the data transfer device can be connected to each other temporarily or permanently. It can be data interfaces that are only connected to each other can be when the hand dosing device in the data transfer device is inserted. The data interfaces can also be independent of which are connected to one another, whether the manual dosing device in the Data transfer device is used.

The data interfaces of the hand dosing device and the data transfer device can communicate with each other through radio transmitters and Radio receiver must be connected. The data interfaces can also be used together have communicating IR transmitters and IR receivers. Hereby a permanent connection of the data interfaces or a wireless remote control favors. In addition or instead, the Data interfaces have interconnectable electrical contacts, by inserting the hand dosing device into the data transfer device can be connectable.

The electronic control device preferably has a microcomputer, especially a microcontroller. The data transfer device can be connected to a separate data processing system, for example with a PC, or an integrated data processing system have, in particular a microcomputer or microcontroller.

The electronic control and / or regulating device and / or the data processing system can conventional input and output and storage facilities have, including a removable storage medium. A program for the Remote control and / or calibration of the hand dosing device available his. This favors the equipment of the dosing system with software as required and updated.

The hand dosing device can work independently of the mains. In particular it can be provided with a chargeable voltage source, for example one or more batteries. In this case it can be one with the have chargeable voltage source connected charging interface and can the data transfer device is a charging part for charging the voltage source and a charging interface connected to the charging part for connection with the charging interface of the hand dosing device. The Loading interfaces of the hand dosing device and the data transfer device can have interacting electrical charging contacts. This can coincide with the contacts of the data interfaces. The Data transmission can in particular be based on the charging voltage or the charging current of the charging unit. By modulating the charging voltage or the Charge currents can transmit data on the same physical channel will be realized.

The data transfer device can be designed as a stationary device. In particular in this case the hand dosing device can also be used as a stationary device Device or used as an automatic dosing device when it is in the data transfer device is inserted. Then the power supply to the Manual dosing device must be ensured via the charging unit.

Further refinements of the invention are specified in the subclaims.

The invention is described below with reference to the accompanying drawings preferred embodiments explained in more detail.

Fig. 1

Handdosiervorrichtung für Dosiersysteme gemäß Fig. 2 bis 5 im detaillierten Blockschaltbild;

Fig. 2

ein Dosiersystem mit Funk-Datenschnittstellen im Blockschaltbild;

Fig. 3

ein Dosiersystem mit IR-Datenschnittstellen im Blockschaltbild;

Fig. 4

ein Dosiersystem mit Kontakt-Datenschnittstellen im Blockschaltbild;

Fig. 5

ein Dosiersystem mit Kontakt-Datenschnittstellen und in die Ladestation integrierter Datenverarbeitungsanlage im Blockschaltbild;

Fig. 6

Kommunikation zwischen Dosiersystem und Datenverarbeitungsanlage im schematischen Blockablaufdiagramm.

The drawings show:

Fig. 1

Manual dosing device for dosing systems according to Figures 2 to 5 in the detailed block diagram.

Fig. 2

a dosing system with radio data interfaces in the block diagram;

Fig. 3

a dosing system with IR data interfaces in the block diagram;

Fig. 4

a dosing system with contact data interfaces in the block diagram;

Fig. 5

a dosing system with contact data interfaces and data processing system integrated in the charging station in a block diagram;

Fig. 6

Communication between dosing system and data processing system in a schematic block flow diagram.

When discussing the various embodiments are for matching Elements of the invention have been given the same reference numbers. In this respect, the description is valid for all exemplary embodiments.

According to Fig. 1, the electronic hand-held dosing device consists essentially from six functional areas, namely a drive device 1, a displacement device 2, an electronic control and / or Control device 3, an electrical voltage source 4, an operating device 5 and a display device 6.

The drive device 1 has an electric drive motor that is designed as a stepper motor 7. An axis 8 is formed by means of the stepping motor 7 can be moved linearly back and forth. It also belongs to the drive device an engine stage in the form of two H-bridges 9, the control the stepper motor 7 is used. This includes one known to those skilled in the art Eight power transistors connected in an H arrangement, with which the Stepper motor 7 via supply lines 10 in the forward and reverse directions can be operated.

The displacement device 2 has a piston 11 on the axis 8 is fixed. The piston 11 is displaceable in a cylinder 12. This is connected via a channel 13 to a metering tip 14 by the device is separable.

A microcontroller belongs to the electronic control and / or regulating device 3 15, in particular a timer, a working memory and a integrated non-volatile memory. The microcontroller controls the H-bridges via control lines 16.

A bidirectional device belongs to the electronic control and / or regulating device 3 serial interface 17, which has electrical sliding contacts 18 and is connected to the microcontroller 115 via data lines 19. Further This includes an EEPROM 20, which is connected to the microcontroller via data lines 21 15 is connected.

In addition, the electronic control and / or regulating device 3 a step-up converter 22 for generating the supply voltage of the Stepper motor 7, which feeds the H-bridges 9 via supply lines 23. Control lines 24 connect the microcontroller 15 to the step-up converter 22.

Another component of the control and / or regulating device 3 is another Step-up converter 25, which connects the microcontroller 15 via additional supply lines 26 supplied.

The axis 8 of the stepping motor 7 is assigned a limit switch 27 which is monitored by a microcontroller 15 via a control line 28 in order to to enable zero adjustment.

The electrical voltage source 4 comprises two NiMH batteries 29, the Supply voltage via feed lines 30, the step-up converter 22 and the further step-up converter 25 is supplied. The supply voltage of the two Batteries 29 are supplied to the microcontroller 15 via control lines 31. A charging current control is also part of the electrical voltage source 4 32, on the one hand via charging contacts 33, which act as sliding contacts are executed, can be connected to an external power source and on the other hand is connected to the batteries 29 via charging lines 34. The charging current control 32 is also via control lines 35 for the charging voltage and via charging current control lines 36 each with the microcontroller 15 connected.

The operating device 5 comprises an input keyboard 37 which is connected via lines 38 is connected to the microcontroller 15. It also includes release buttons 39, which is connected to the microcontroller 15 via lines 40.

The display device 6 is an LCD display which is connected via lines 41 is connected to the microcontroller 15, which contains a display control.

The execution of functional areas 1 to 6 and the associated functional blocks is familiar to the expert. All functional areas 1 to 6 are in or on a - not shown - pipette housing of a hand-held dosing device formed, hereinafter referred to overall as 42 becomes. Basically, this manual dosing device 42 works as follows:

The control software is stored in the microcontroller 15. Dosing data can entered before a dosing process using the input keyboard 37 become. Individual dosing processes can be triggered by means of the trigger buttons 39. The display 6 shows entered data, control commands and operating states the hand dosing device 42.

The total supply voltage of the two battery cells 29 is 2.4 volts. This is further converter 25 to 3.3 volts supply voltage regulated for the microcontroller 15.

Depending on the control via the control lines 24, the step-up converter switches 22 the supply voltage of the batteries 29 as the supply voltage the supply lines 23 through or increases this to 6 or 8 volts. There the microcontroller 15 the operation of the stepper motor 7 via the control lines 16 controls, he knows their respective voltage requirements and controls the step-up converter 22 accordingly.

The supply voltage is from the microcontroller 15 via the control lines 31 checked. If it jumps below a permissible value, the display shows 6 a corresponding information is output. By connecting the charging contacts 33 to an external power supply unit can be charged if necessary Batteries 29 take place. The charging current is via the charging current control lines 36 corresponding to the state of charge determined via the control lines 31 the batteries 29 controlled.

Hand dosing devices 42 of the above type come - in part somewhat modified - used in the dosing systems discussed below.

2, a hand dosing device 42 'works with a charging station 43 'together. The charging contacts 33 of the manual dosing device 42 ' corresponding charging contacts 44 assigned to the charging station 43.

In deviation from FIG. 1, however, the serial interface 17 comprises one RF transmitter and receiver coupled to an antenna 45. The Charging station 43 'has a corresponding RF transmitter and receiver 46 and an antenna 47 connected thereto for radio communication with the Hand dosing device 42 '.

The RF transmitter and receiver 46 is via a serial interface 48 Charging station 43 connected to an external PC 49.

This configuration enables the batteries 29 to be charged Inserting the manual dosing device 42 'into the charging station 43'. About the Radio connection between the antennas 45, 47 can data between the PC 49 and the hand dosing device 42 'are exchanged, both when the hand dosing device 42 'is inserted into the charging station 43' as even if it is spatially separated from it. Using the PC 49 can Operating parameters, routines, programs or program parts in the EEPROM 20 of the hand dosing device 42 is written in or out of this be read out. Remote control of the PC 49 is also possible Manual dosing device 42 'possible.

3, the hand dosing device 42 ″ and the charging station 43 ″ in turn connectable charging contacts 43, 44. In However, the data interface 17 differs from the previous example an IR transmitter 49 and an IR receiver 50. In another Deviation, the data interface 46 of the charging station 43 ″ includes an IR receiver 51 and an IR transmitter 52.

Via the IR transmitter 49, 52 and IR receiver 51, 50, the PC 49 and the hand dosing device 42 ″ in turn exchange data, in principle both when the hand dosing device 42 ″ is inserted into the charging station 43 ″ as if it is outside of it.

According to FIG. 4, a hand dosing device 42 according to FIG. 1 is used. The charging contacts 43 of the same are in turn charging contacts 44 of the Charging station 43 assigned. The electrical contacts 18 of the data interface 17 are electrical contacts 53 of the data interface 46 of the charging station 43 assigned.

With this version the data transfer between PC 49 works and manual dosing device 42 when the latter enters the charging station 43 is inserted. This version is relatively simple and special reliable.

5 differs from that of FIG. 4 in that the charging station 43 '' 'has an integrated microcontroller system 54 with a non-volatile memory 55 and a keyboard 56, a display 57, a serial interface 58 and an exchangeable storage medium 59 having. The removable storage medium 59 can be an EEPROM card, a SMART card, a FLASH card, a disc, etc.

The microcontroller system 54 can take over the functions of the PC 49. In particular, he can control the data traffic to the manual dosing device 42, the triggering of metering functions of the manual metering device 42, the storage of data in internal and external memories 55, 59, 20 of the charging station 43 '' 'and the manual dosing device 42, the data input and triggering the hand dosing device 42 via the keyboard 56, the Display of data on the display 57 and communication with a serve external control (PC) via the serial interface 58.

Serial communication between the dosing system and the data processing system is explained in more detail below with reference to FIG. 6.

There is one between the data processing system and the dosing system Agreement regarding the implemented commands and the transmission framework in the form of a protocol. So that is a common one Language set by means of which communication between dosing system and data processing system.

1. Manipulation des nicht-flüchtigen Speichers (z. B. EEPROM 20):

• Schreiben eines Wertes an eine beliebige Adresse des nicht-flüchtigen Speichers.
• Lesen des Inhaltes einer beliebigen Adresse des nicht-flüchtigen Speichers.

Hiermit werden die gerätetypspezifischen, gerätespezifischen und Anwender-Parameter ausgetauscht.

2. Lesen von internen Statusmeldungen des Dosiersystems:

• Z. B. ist der Endschalter (z.B. Endlageschalter 27) betätigt?
• Welcher Fehler wird gemeldet?
• Ist der Motor aktiv?

3. Auslösung von internen Vorgängen im Dosiersystem:

• Z.B. Löschen aller Fehlermeldungen,
• Auslösen von Speicherinitialisierungen,
• Prüfroutinen für die Fertigung,
• Auslösung von Motoraktionen und somit Fernauslösung von Dosierfunktionen,
• Simulation von Tastendrücken,
• Definition von eigenen Abläufen etc.

4. Flashloader:
Lesen und Programmieren eines neuen Programmes (oder eines Teiles davon) in einen nicht-flüchtigen Programmspeicher (z.B. FLASHPROM).

In principle, the following types of commands are possible:

1. Manipulation of the non-volatile memory (e.g. EEPROM 20):

• Write a value to any address in the non-volatile memory.
• Read the contents of any address of the non-volatile memory.

The device type-specific, device-specific and user parameters are hereby exchanged.

2. Reading internal status messages of the dosing system:

• For example, is the limit switch (eg limit switch 27) actuated?
• What error is being reported?
• Is the engine active?

3. Triggering of internal processes in the dosing system:

• Eg deleting all error messages,
• Trigger memory initializations,
• Test routines for production,
• Triggering of motor actions and thus remote triggering of dosing functions,
• Simulation of key presses,
• Definition of own processes etc.

4. Flashloader:
Reading and programming a new program (or a part of it) in a non-volatile program memory (eg FLASHPROM).

Claims (22)

Method for operating an electronic dosing system with an electronic manual dosing device (42), the a drive device (1) having an electric drive (7), at least one displacement device (2) which can be driven by the drive device (1) for metering liquid, a program-controlled electronic control and / or regulating device (3), in particular for the drive (7), at least one non-volatile read / write memory (20), an electrical voltage source (29) in particular for the electrical drive (7) and the electronic control and / or regulating device (3) and has a data interface (17) connected to the electronic control and / or regulating device,
With a data processing system (49),
and with a data transfer device (43) which has a data interface (46) for connecting the data interface (17) of the dosing device (42) to the data processing system (49),
wherein by means of the data processing system (49) via the data interfaces (17, 46) device-specific and / or device-specific parameters and / or User parameters and / or Routines for performing operations and / or the program and / or at least one program part can be written into and / or read from the read / write memory (20) and / or the manual dosing device (42) can be controlled remotely. The method of claim 1, wherein the data interfaces (17, 46) communicate with each other via contact. Method according to Claim 1 or 2, in which the data interfaces (17, 46) communicate with each other wirelessly. Method according to Claim 3, in which the data interfaces (17, 46) communicate with each other via radio, optically, inductively and / or capacitively. Dosing system for performing the method according to one of the Claims 1 to 4, characterized in that the data interfaces (17, 46) of the dosing device (42) and the data transfer device (43) have interconnectable electrical contacts (18, 53). Dosing system for performing the method according to one of the Claims 1 to 4, in which the data interfaces (17, 46) of the metering device (42) and the data transfer device (43) with each other communicating radio transmitters and radio receivers and / or IR transmitters (49, 52) and receivers (50, 51). Dosing system for performing the method according to one of the Claims 1 to 4, in particular according to claim 5 or 6, wherein the Data interfaces (17, 46) of the dosing device (42) and the data transfer device (43) are serial data interfaces. Dosing system for performing the method according to one of the Claims 1 to 4, in particular according to one of claims 5 to 7, in which the electronic control and / or regulating device (3) one Microcomputer or microcontroller (15). Dosing system according to claim 8, wherein the non-volatile read-write memory a flash memory of the microcomputer or microcontroller is. Dosing system for performing the method according to one of the Claims 1 to 4, in particular according to one of claims 5 to 9, in which with the data interface (46) of the data transfer device (43) connected data processing system (49) to the data transfer device (43) connected PC. Dosing system for performing the method according to one of the Claims 1 to 4, in particular according to one of claims 5 to 10, in with the data interface (46) of the data transfer device (43) a data processing system integrated in the data transfer device (43) (54) is connected. Dosing system according to claim 11, wherein the data processing system (49, 54) comprises a microcomputer or microcontroller. Dosing system for performing the method according to one of the Claims 1 to 4, in particular according to one of claims 5 to 12, in which the electronic control device (3) and / or the data processing system (49, 54) a non-volatile memory (20, 55) and / or a keyboard (37, 39; 56) and / or a display (6, 57) and / or a serial interface (17, 58) and / or a replaceable one Have storage medium (59). Dosing system for performing the method according to one of the Claims 1 to 4, in particular according to one of claims 5 to 13, in which the hand dosing device (42) one with a rechargeable voltage source (29) connected charging interface (33) and the data transfer device (43) a charging part for charging the voltage source (29) and a charging interface (44) connected to the charging part (43) for Connect to the charging interface (33) of the manual dosing device (42) Has. Dosing system according to claim 14, wherein the dosing device (42) and the data transfer device (43) has common charging (33, 44) and have data interfaces (17, 46). Dosing system according to one of claims 14 or 15, wherein the electronic control and / or regulating device (3) with a charging current control (32) the metering device (42) for controlling the charging current according to the state of charge of the voltage source (29) works together. Dosing system according to claim 16, wherein the electronic control and / or Control device (3) the state of charge by monitoring the electrical supply voltage of the voltage source (29) determined. Dosing system for performing the method according to one of the Claims 1 to 4, in particular according to one of claims 14 to 17, in which the data transfer device (43) has several charging interfaces (44) for simultaneously charging the voltage sources (29) of several Dosing devices (42) and / or several data interfaces (46) for simultaneous communication with the data interfaces (17) of several Dosing devices (42). Dosing system according to one of claims 14 to 18, wherein the data transfer device (43) at least one charging interface (44) for one from the dosing device (42) removable rechargeable electrical Has voltage source (29). Dosing system according to one of claims 14 to 19, in which the charging interfaces (33, 44) of the dosing device (42) and the data transfer device (43) and / or the removable voltage source (29) have interconnectable electrical charging contacts. Dosing system for performing the method according to one of the Claims 1 to 4, in particular according to claim 5 to 20, wherein the Hand dosing device (42) is network-independent. Dosing system for performing the method according to one of the Claims 1 to 4, in particular according to claim 5 to 21, in which the Data transfer device is a stationary device.

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