EP0941124A4 - Antisense oligonucleotide compositions for selectively killing cancer cells - Google Patents
Antisense oligonucleotide compositions for selectively killing cancer cellsInfo
- Publication number
- EP0941124A4 EP0941124A4 EP96941450A EP96941450A EP0941124A4 EP 0941124 A4 EP0941124 A4 EP 0941124A4 EP 96941450 A EP96941450 A EP 96941450A EP 96941450 A EP96941450 A EP 96941450A EP 0941124 A4 EP0941124 A4 EP 0941124A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cancer cells
- antisense oligonucleotide
- killing cancer
- oligonucleotide compositions
- selectively killing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1996/018795 WO1998022142A1 (en) | 1994-01-10 | 1996-11-21 | Antisense oligonucleotide compositions for selectively killing cancer cells |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0941124A1 EP0941124A1 (en) | 1999-09-15 |
EP0941124A4 true EP0941124A4 (en) | 2004-12-15 |
Family
ID=22256184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96941450A Withdrawn EP0941124A4 (en) | 1996-11-21 | 1996-11-21 | Antisense oligonucleotide compositions for selectively killing cancer cells |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0941124A4 (en) |
AU (1) | AU714393B2 (en) |
CA (1) | CA2272341A1 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992015680A1 (en) * | 1991-03-06 | 1992-09-17 | Board Of Regents, The University Of Texas System | Methods and compositions for the selective inhibition of gene expression |
WO1994008625A1 (en) * | 1992-10-21 | 1994-04-28 | Temple University - Of The Commonwealth System Of Higher Education | Combination of antineoplastic agent and antisense oligonucleotides for treatment of cancer |
WO1995008350A1 (en) * | 1993-09-20 | 1995-03-30 | Reed John C | REGULATION OF bcl-2 GENE EXPRESSION |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5302706A (en) * | 1991-12-16 | 1994-04-12 | Baylor College Of Medicine | Senescent cell derived inhibitors of DNA synthesis |
WO1997003681A1 (en) * | 1995-07-20 | 1997-02-06 | Worcester Foundation For Biomedical Research, Inc. | Methods for selectively killing or inhibiting the growth of cells expressing the waf1 gene |
-
1996
- 1996-11-21 CA CA002272341A patent/CA2272341A1/en not_active Abandoned
- 1996-11-21 EP EP96941450A patent/EP0941124A4/en not_active Withdrawn
- 1996-11-21 AU AU10591/97A patent/AU714393B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992015680A1 (en) * | 1991-03-06 | 1992-09-17 | Board Of Regents, The University Of Texas System | Methods and compositions for the selective inhibition of gene expression |
WO1994008625A1 (en) * | 1992-10-21 | 1994-04-28 | Temple University - Of The Commonwealth System Of Higher Education | Combination of antineoplastic agent and antisense oligonucleotides for treatment of cancer |
WO1995008350A1 (en) * | 1993-09-20 | 1995-03-30 | Reed John C | REGULATION OF bcl-2 GENE EXPRESSION |
Non-Patent Citations (12)
Title |
---|
AKIRA MIYAJIMA ET AL.: "Role of oxygen-free radicals in Cisplatin-induced citotoxycity of bladder cancer cells", JOURNAL OF UROLOGY, vol. 153, no. 4 suppl., 1995, pages 523A, XP008036776 * |
BISHOP M.R. ET AL.: "Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, vol. 14, no. 4, April 1996 (1996-04-01), NEW YORK, NY, US, pages 1320 - 1326, XP000891695, ISSN: 0732-183X * |
COPPLE B. ET AL.: "Oligonucleotides directed to p53 mRNA cause increased sensitivity to radical oxygen induced cytotoxicity", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, ANUAL MEETING, vol. 35, March 1994 (1994-03-01), pages 307, XP008036802 * |
DEL BUFALO D. ET AL.: "Effect of cisplatin and c-myb antisense phosphorothioate oligodeoxynucleotides combination on a human colon carcinoma cell line in vitro and in vivo", BRITISH JOURNAL OF CANCER, vol. 74, August 1996 (1996-08-01), pages 387 - 393, XP008036590 * |
FIELDS A.L. ET AL.: "Mature results of a phase II trial of concomitant Cisplatin/pelvic radiotherapy for locally advanced squamous cell carcinoma of the cervix", GYNECOLOGIC ONCOLOGY, vol. 61, no. 3, June 1996 (1996-06-01), pages 416 - 422, XP002300336 * |
KAIREMO K.J.A. ET AL.: "Dosimetry of radionuclide therapy using radiophosphonated antisense oligodeoxynucleotide phosphorothioates based on animal pharmacokinetic and tissue distribution data", ANTISENSE RESEARCH AND DEVELOPMENT, MARY ANN LIEBERT, vol. 6, no. 3, 21 September 1996 (1996-09-21), NEW YORK, US, pages 215 - 220, XP000616037, ISSN: 1050-5261 * |
KAIREMO K.J.A. ET AL.: "Oligoradionuclidetherapy using radiolabelled antisense oligodeoxynucleotide phosphorothioates", ANTI-CANCER DRUG DESIGN, vol. 11, no. 6, 1 September 1996 (1996-09-01), BASINGSTOKE, GB, pages 439 - 449, XP000615940, ISSN: 0266-9536 * |
MIZUTANI Y. ET AL.: "Enhancement of sensitivity of urinary bladder tumor cells to cisplatin by c-myc antisense oligonucleotide", CANCER, vol. 74, no. 9, 1 November 1994 (1994-11-01), pages 2546 - 2554, XP008036589 * |
NIEBOROWSKA-SKORSKA M. ET AL.: "Oncogene-targeted antisense oligodeoxynucleotides combined with chemotherapy or immunotherapy: a new approach for tumor treatment?", FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, vol. 32, no. 1, 1994, pages 35 - 40, XP008036645 * |
See also references of WO9822142A1 * |
SURESH A.ET AL.: "Role of Manganese Superoxide Dismutase in radioprotection using gene transfer studies", CANCER GENE THERAPY, vol. 1, no. 1, 1994, pages 85 - 90, XP008036692 * |
WONG G.H.W.: "Protective roles od cytokines against radiation: induction of mitochondrial MnSOD", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1271, 1995, pages 205 - 209, XP002299874 * |
Also Published As
Publication number | Publication date |
---|---|
EP0941124A1 (en) | 1999-09-15 |
CA2272341A1 (en) | 1998-05-28 |
AU1059197A (en) | 1998-06-10 |
AU714393B2 (en) | 2000-01-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990615 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20041028 |
|
17Q | First examination report despatched |
Effective date: 20050503 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060630 |