EP0833159A2 - Direct read lateral flow assay for small analytes - Google Patents
Direct read lateral flow assay for small analytes Download PDFInfo
- Publication number
- EP0833159A2 EP0833159A2 EP97307508A EP97307508A EP0833159A2 EP 0833159 A2 EP0833159 A2 EP 0833159A2 EP 97307508 A EP97307508 A EP 97307508A EP 97307508 A EP97307508 A EP 97307508A EP 0833159 A2 EP0833159 A2 EP 0833159A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- analyte
- solid support
- frame
- sample
- area
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
Abstract
Description
PCB ppm | Log [PCB] | Pixel Value |
0.5 | -.301 | 16.3 |
3 | .477 | 50.4 |
3 | .477 | 48.7 |
5 | .699 | 54.3 |
10 | 1 | 68.8 |
22 | 1.342 | 81.6 |
22 | 1.342 | 78.7 |
Claims (10)
- A process for determining the presence or absence or amount of an analyte in a sample. comprising:a) providing a solid support wherein said solid support has three areas comprising:(i) a sample addition area;(ii) a capture area; and(iii) a read-out area having at least one zone,b) contacting the sample addition area with the sample suspected of containing analyte, wherein said sample has been mixed with a preparation containing anti-analyte antibodies or anti-analyte analog antibodies and tracer wherein said tracer is coated with analyte or analyte analog and a label which can bind to said complementary binding partner;c) flowing said mixture of sample and solution along the flow path of the solid support from the sample addition area to the capture area through the read-out area to the distal end of the solid support; andd) detecting the presence, absence or amount of tracer in the one or more zone(s) in the read-out area as a function of the amount of analyte in the sample.
- The process of Claim 1 wherein said tracer is a first tracer, wherein said read-out area has at least two zones, wherein the first zone is a control zone having anti-analyte antibody to a second irrelevant analyte, wherein said second irrelevant analyte, attached to a second tracer, is added to the sample for control purposes, and further wherein said second zone is a zone as in Claim 1, and wherein any additional zones are identical to the second zone.
- The process of Claim 1 wherein said solid support further comprises a housing for said solid support, said housing comprising a frame which surrounds and covers the entire solid support, said frame having a hole which opens over the sample addition area at the front end of the solid support, a first window in the frame for viewing the read-out area of the support, and a second window in the frame to view the distal end of the support;and further wherein said sample mixture is contacted with said sample addition area by pouring said mixture through said hole in the frame of the housing.
- The process of Claim 1 wherein another tracer is added to the mixture to detect the end of the assay by viewing the second window in the frame of the housing covering the solid support.
- The process of Claim 2 wherein said solid support further comprises a housing for said solid support, said housing comprising a frame which surrounds and covers the entire solid support, said frame having a hole which opens over the sample addition area at the front end of the solid support, a first window in the frame for viewing the read-out area of the support, and a second window in the frame to view the distal end of the support;and further wherein said sample mixture is contacted with said sample addition area by pouring said mixture through said hole in the frame of the housing.
- The process of Claim 2 wherein a third tracer is added to the mixture to detect the end of the assay by viewing the second window in the frame of the housing covering the solid support.
- A kit for determining the presence, absence or amount of an analyte in a sample, comprising:a solid support having a flow path and sequentially, three areas comprising:(i) a sample addition area;(ii) a capture area; and(iii) a read-out area containing at least one zone,
a preparation to be added to said sample, said preparation containing anti-analyte antibodies or anti-analyte analog antibodies and the tracer wherein said tracer is coated with analyte or analyte analog and said label. - The kit of Claim 7 wherein said read-out area has at least two zones, wherein the first zone is a control zone having antibody to a second irrelevant analyte which is a control analyte, and further wherein said second zone has immobilized thereon complementary binding partner to said label on said tracer and wherein any additional zones are the same as the second zone, and the kit further comprising: an additional preparation to be added to the sample and preparation in Claim 19, said additional preparation containing said second irrelevant analyte, wherein said second analyte is attached to a second tracer.
- The kit of Claim 7 wherein said solid support further comprises a housing for said solid support, said housing comprising a frame which surrounds and covers the entire solid support, said frame having a hole which opens over the sample addition area at the front end of the solid support, a first window in the frame for viewing the read-out area of the support, and a second window in the frame to view the distal end of the support.
- The kit of Claim 8 wherein said solid support further comprises a housing for said solid support, said housing comprising a frame which surrounds and covers the entire solid support, said frame having a hole which opens over the sample addition area at the front end of the solid support, a first window in the frame for viewing the read-out area of the support, and a second window in the frame to view the distal end of the support.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/719,221 US5798273A (en) | 1996-09-25 | 1996-09-25 | Direct read lateral flow assay for small analytes |
US719221 | 1996-09-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0833159A2 true EP0833159A2 (en) | 1998-04-01 |
EP0833159A3 EP0833159A3 (en) | 1998-08-12 |
Family
ID=24889244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97307508A Withdrawn EP0833159A3 (en) | 1996-09-25 | 1997-09-25 | Direct read lateral flow assay for small analytes |
Country Status (5)
Country | Link |
---|---|
US (1) | US5798273A (en) |
EP (1) | EP0833159A3 (en) |
JP (1) | JP3174543B2 (en) |
AU (1) | AU3923897A (en) |
CA (1) | CA2215619A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000042434A1 (en) * | 1999-01-09 | 2000-07-20 | Bernd Pevec | Method and device for determining an analyte |
WO2003058220A1 (en) * | 2001-12-24 | 2003-07-17 | Kimberly-Clark Worldwide, Inc. | Reading device, method, and system for conducting lateral flow assays |
WO2005057215A1 (en) * | 2003-11-21 | 2005-06-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based lateral flow assay devices that utilize phosphorescent detection |
US7041787B2 (en) | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases |
WO2006117574A2 (en) * | 2005-05-04 | 2006-11-09 | Lateral Laboratories Limited | Liquid flow assays utilising a combined detection and control zone |
US7651841B2 (en) | 2001-12-24 | 2010-01-26 | Kimberly-Clark Worldwide, Inc. | Polyelectrolytic internal calibration system of a flow-through assay |
US7662643B2 (en) | 2002-12-19 | 2010-02-16 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in membrane-based assay devices |
US7670786B2 (en) | 2002-08-27 | 2010-03-02 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
US7829328B2 (en) | 2003-04-03 | 2010-11-09 | Kimberly-Clark Worldwide, Inc. | Assay devices that utilize hollow particles |
US7851209B2 (en) | 2003-04-03 | 2010-12-14 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in assay devices |
US8137985B2 (en) | 2001-12-24 | 2012-03-20 | Kimberly-Clark Worldwide, Inc. | Polyelectrolytic internal calibration system of a flow-through assay |
CN106442973A (en) * | 2016-09-07 | 2017-02-22 | 北京热景生物技术股份有限公司 | Fungaltoxin multi-parameter quantitative detection kit in field of food security |
Families Citing this family (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997006439A1 (en) * | 1995-08-09 | 1997-02-20 | Quidel Corporation | Test strip and method for one step lateral flow assay |
US6437563B1 (en) | 1997-11-21 | 2002-08-20 | Quantum Design, Inc. | Method and apparatus for making measurements of accumulations of magnetically susceptible particles combined with analytes |
US6824997B1 (en) | 1998-09-18 | 2004-11-30 | Binax, Inc. | Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies |
US9134303B1 (en) | 1998-08-25 | 2015-09-15 | Alere Scarborough, Inc. | ICT immunoassay for Legionella pneumophila serogroup 1 antigen employing affinity purified antibodies thereto |
US6245577B1 (en) | 1998-09-11 | 2001-06-12 | Midland Bioproducts Corporation | IgG antibody testing method |
US6441152B1 (en) * | 1998-12-08 | 2002-08-27 | Boston Probes, Inc. | Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices |
AU1241901A (en) * | 1999-11-24 | 2001-06-04 | Biotronics Technologies, Inc. | Devices and methods for detecting analytes using electrosensor having capture reagent |
US6316205B1 (en) | 2000-01-28 | 2001-11-13 | Genelabs Diagnostics Pte Ltd. | Assay devices and methods of analyte detection |
US6607922B2 (en) | 2000-03-17 | 2003-08-19 | Quantum Design, Inc. | Immunochromatographic assay method and apparatus |
US6699722B2 (en) | 2000-04-14 | 2004-03-02 | A-Fem Medical Corporation | Positive detection lateral-flow apparatus and method for small and large analytes |
US6600057B2 (en) | 2000-12-29 | 2003-07-29 | Kimberly-Clark Worldwide, Inc. | Matrix metalloproteinase inhibitors |
US6833111B2 (en) | 2001-04-13 | 2004-12-21 | Varian, Inc. | Multiple analyte assaying device with a multiple sample introduction system |
US6916626B1 (en) * | 2001-04-25 | 2005-07-12 | Rockeby Biomed Ltd. | Detection of Candida |
US7393696B2 (en) * | 2001-09-28 | 2008-07-01 | Aspenbio Pharma, Inc. | Bovine pregnancy test |
US6720160B2 (en) | 2001-10-11 | 2004-04-13 | Helica Biosystems, Inc. | Method for simultaneous detection of multiple microbial antigens in biological specimens from mastitic animals |
US20030119073A1 (en) * | 2001-12-21 | 2003-06-26 | Stephen Quirk | Sensors and methods of detection for proteinase enzymes |
EP1535241A1 (en) | 2002-08-20 | 2005-06-01 | Cyvera Corporation | Diffraction grating-based optical identification element |
US7901630B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
US7900836B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
US7619819B2 (en) | 2002-08-20 | 2009-11-17 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
US7508608B2 (en) | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
US7164533B2 (en) | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
AU2003274979A1 (en) | 2002-09-12 | 2004-04-30 | Cyvera Corporation | Chemical synthesis using diffraction grating-based encoded optical elements |
US20100255603A9 (en) | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
AU2003278827A1 (en) | 2002-09-12 | 2004-04-30 | Cyvera Corp. | Method and apparatus for labelling using diffraction grating-based encoded optical identification elements |
US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
US7781172B2 (en) | 2003-11-21 | 2010-08-24 | Kimberly-Clark Worldwide, Inc. | Method for extending the dynamic detection range of assay devices |
TWI340829B (en) * | 2002-12-27 | 2011-04-21 | Transpacific Systems Llc | Method for determining a response of each probe zone on a test strip |
US7197169B2 (en) * | 2003-01-02 | 2007-03-27 | Kuo-Jeng Wang | Method for detecting a response of each probe zone on a test strip |
US7722817B2 (en) * | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
US7943395B2 (en) | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
US7713748B2 (en) | 2003-11-21 | 2010-05-11 | Kimberly-Clark Worldwide, Inc. | Method of reducing the sensitivity of assay devices |
US7943089B2 (en) | 2003-12-19 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Laminated assay devices |
US7723124B2 (en) * | 2004-02-09 | 2010-05-25 | Rapid Pathogen Screening, Inc. | Method for the rapid diagnosis of targets in human body fluids |
US7433123B2 (en) | 2004-02-19 | 2008-10-07 | Illumina, Inc. | Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein |
US7521226B2 (en) | 2004-06-30 | 2009-04-21 | Kimberly-Clark Worldwide, Inc. | One-step enzymatic and amine detection technique |
AU2005307746B2 (en) | 2004-11-16 | 2011-05-12 | Illumina, Inc. | And methods and apparatus for reading coded microbeads |
US7925445B2 (en) * | 2004-12-03 | 2011-04-12 | Alverix, Inc. | Read-write assay system |
US8445293B2 (en) * | 2005-02-09 | 2013-05-21 | Rapid Pathogen Screening, Inc. | Method to increase specificity and/or accuracy of lateral flow immunoassays |
US7785899B2 (en) * | 2005-02-18 | 2010-08-31 | Charm Sciences, Inc. | Lateral flow test kit and method for detecting an analyte |
US8709792B2 (en) * | 2005-02-18 | 2014-04-29 | Charm Sciences, Inc. | Lateral flow test kit and method for detecting an analyte |
US7189522B2 (en) | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
US20090061524A1 (en) * | 2005-04-15 | 2009-03-05 | Judith Rishpon | Enzyme-Channeling Based Electrochemical Biosensors |
US20060240569A1 (en) * | 2005-04-20 | 2006-10-26 | Becton, Dickinson And Company | Semi-quantitative immunochromatographic device |
US7803319B2 (en) * | 2005-04-29 | 2010-09-28 | Kimberly-Clark Worldwide, Inc. | Metering technique for lateral flow assay devices |
US7439079B2 (en) * | 2005-04-29 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Assay devices having detection capabilities within the hook effect region |
US7858384B2 (en) * | 2005-04-29 | 2010-12-28 | Kimberly-Clark Worldwide, Inc. | Flow control technique for assay devices |
WO2006130299A2 (en) * | 2005-05-03 | 2006-12-07 | Micronics, Inc. | Microfluidic laminar flow detection strip |
US20070042504A1 (en) * | 2005-08-22 | 2007-02-22 | Yimin Yu | Method for determining substance or substances in liquid sample |
US7829347B2 (en) * | 2005-08-31 | 2010-11-09 | Kimberly-Clark Worldwide, Inc. | Diagnostic test kits with improved detection accuracy |
US7504235B2 (en) * | 2005-08-31 | 2009-03-17 | Kimberly-Clark Worldwide, Inc. | Enzyme detection technique |
US8003399B2 (en) * | 2005-08-31 | 2011-08-23 | Kimberly-Clark Worldwide, Inc. | Nitrite detection technique |
US8778619B2 (en) * | 2005-11-18 | 2014-07-15 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Oxidized cardiolipin and uses to detect cardiolipin antibodies |
JP4837743B2 (en) * | 2005-11-18 | 2011-12-14 | アメリカ合衆国 | Modified cardiolipin and uses thereof |
US7279136B2 (en) | 2005-12-13 | 2007-10-09 | Takeuchi James M | Metering technique for lateral flow assay devices |
US7618810B2 (en) * | 2005-12-14 | 2009-11-17 | Kimberly-Clark Worldwide, Inc. | Metering strip and method for lateral flow assay devices |
US20090053694A1 (en) * | 2005-12-26 | 2009-02-26 | Kriksunov Leo B | Photochemically Amplified Bioassay |
US20070224701A1 (en) * | 2006-02-16 | 2007-09-27 | Becton, Dickinson And Company | Combination vertical and lateral flow immunoassay device |
US7932099B2 (en) * | 2006-02-21 | 2011-04-26 | Nexus Dx, Inc. | Methods and compositions for analyte detection |
AU2007225038B2 (en) * | 2006-03-15 | 2013-08-29 | Perkinelmer Health Sciences, Inc. | Integrated nucleic acid assays |
US7830575B2 (en) | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
US7547557B2 (en) * | 2006-06-13 | 2009-06-16 | Quantum Design, Inc. | Directed-flow assay device |
US20080057528A1 (en) * | 2006-08-30 | 2008-03-06 | Kimberly-Clark Worldwide, Inc. | Detection of hydrogen peroxide released by enzyme-catalyzed oxidation of an analyte |
US7569396B1 (en) | 2006-09-08 | 2009-08-04 | Purplecow Llc | Caffeine detection using internally referenced competitive assays |
US7749775B2 (en) * | 2006-10-03 | 2010-07-06 | Jonathan Scott Maher | Immunoassay test device and method of use |
US8012761B2 (en) * | 2006-12-14 | 2011-09-06 | Kimberly-Clark Worldwide, Inc. | Detection of formaldehyde in urine samples |
US8377379B2 (en) * | 2006-12-15 | 2013-02-19 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay device |
US7846383B2 (en) * | 2006-12-15 | 2010-12-07 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay device and absorbent article containing same |
US7935538B2 (en) * | 2006-12-15 | 2011-05-03 | Kimberly-Clark Worldwide, Inc. | Indicator immobilization on assay devices |
WO2008154813A1 (en) | 2007-06-15 | 2008-12-24 | Xiamen University | Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof |
EP2215475B1 (en) * | 2007-10-23 | 2016-12-21 | Skannex AS | Immunoassay analysis method |
JP5792614B2 (en) | 2008-04-09 | 2015-10-14 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Sensitive immunoassay using coated nanoparticles |
WO2010011860A1 (en) * | 2008-07-23 | 2010-01-28 | Diabetomics, Llc | Methods for detecting pre-diabetes and diabetes |
DE102009010563A1 (en) | 2009-02-16 | 2010-08-26 | Matthias W. Engel | Device for the detection of analytes in body fluids |
US20110076697A1 (en) * | 2009-04-28 | 2011-03-31 | Innovative Laboratory Technologies, Inc. | Lateral-flow immuno-chromatographic assay devices |
WO2010132447A2 (en) | 2009-05-11 | 2010-11-18 | Diabetomics, Llc | Methods for detecting pre-diabetes and diabetes using differential protein glycosylation |
CA2786569C (en) | 2010-01-29 | 2019-04-09 | Micronics, Inc. | Sample-to-answer microfluidic cartridge |
WO2013040142A2 (en) | 2011-09-16 | 2013-03-21 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
US10706955B2 (en) | 2010-03-23 | 2020-07-07 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
US8945943B2 (en) | 2010-05-26 | 2015-02-03 | The Board Of Trustees Of The University Of Illinois | Personal glucose meters for detection and quantification of a broad range of analytes |
WO2011159537A2 (en) * | 2010-06-15 | 2011-12-22 | The Regents Of The University Of California | Method and device for analyte detection |
US8486717B2 (en) | 2011-01-18 | 2013-07-16 | Symbolics, Llc | Lateral flow assays using two dimensional features |
EP3418397B1 (en) | 2012-01-24 | 2020-10-07 | CD Diagnostics, Inc. | System for detecting infection in synovial fluid |
EP3415919B1 (en) | 2012-02-07 | 2020-07-29 | Intuitive Biosciences Inc. | Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates |
CN103513035B (en) * | 2012-06-28 | 2016-09-21 | 北京勤邦生物技术有限公司 | A kind of test strips detecting Aflatoxins M1 and method |
US9874556B2 (en) | 2012-07-18 | 2018-01-23 | Symbolics, Llc | Lateral flow assays using two dimensional features |
KR102410763B1 (en) | 2012-08-17 | 2022-06-20 | 모르포시스 아게 | Complex-specific antibodies and antibody fragments and its use |
CA2891972A1 (en) | 2012-11-21 | 2014-06-12 | Oslo Universitetssykehus Hf | Systems and methods for monitoring biological fluids |
US11320418B2 (en) | 2012-12-12 | 2022-05-03 | Iassay, Inc. | Modular hand-held point of care testing system |
US10518262B2 (en) | 2012-12-21 | 2019-12-31 | Perkinelmer Health Sciences, Inc. | Low elasticity films for microfluidic use |
WO2014100732A1 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Fluidic circuits and related manufacturing methods |
EP2935559B1 (en) | 2012-12-21 | 2020-09-16 | PerkinElmer Health Sciences, Inc. | Fluorescence detection system |
US8968677B2 (en) | 2013-01-22 | 2015-03-03 | Quantum Design International, Inc. | Frazil ice conjugate assay device and method |
US9949671B2 (en) | 2013-03-13 | 2018-04-24 | Orthoaccel Technologies, Inc. | Diagnostic mouthpieces |
US10386377B2 (en) | 2013-05-07 | 2019-08-20 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
JP6484222B2 (en) | 2013-05-07 | 2019-03-13 | マイクロニクス, インコーポレイテッド | Devices for nucleic acid preparation and analysis |
CN105189750B (en) | 2013-05-07 | 2020-07-28 | 珀金埃尔默健康科学有限公司 | Method for preparing nucleic acid-containing sample using clay mineral and alkaline solution |
WO2015038978A1 (en) | 2013-09-13 | 2015-03-19 | Symbolics, Llc | Lateral flow assays using two dimensional test and control signal readout patterns |
GB2548653A (en) | 2014-04-02 | 2017-09-27 | Chembio Diagnostic Systems Inc | Immunoassay utilizing trapping conjugate |
US20160116466A1 (en) | 2014-10-27 | 2016-04-28 | Chembio Diagnostic Systems, Inc. | Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses |
US9981264B2 (en) | 2014-11-04 | 2018-05-29 | Grace Bio-Labs, Inc. | Nitrocellulose extrusion for porous film strips |
WO2016172660A1 (en) | 2015-04-23 | 2016-10-27 | Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno | Fungal detection using mannan epitope |
CN108136051A (en) | 2015-08-04 | 2018-06-08 | Cd诊断股份有限公司 | The method for detecting bad local organization reaction (ALTR) necrosis |
US10094793B2 (en) | 2015-09-19 | 2018-10-09 | The Board Of Regents Of The University Of Texas System | Nanomaterial-based photothermal immunosensing for quantitative detection of disease biomarkers |
WO2017077392A1 (en) | 2015-11-06 | 2017-05-11 | Oslo Universitetssykehus Hf | Methods and devices for detecting methanol poisoning using formate oxidase |
EP3978619A1 (en) | 2015-12-09 | 2022-04-06 | Intuitive Biosciences, Inc. | Automated silver enhancement system |
US10222383B2 (en) | 2016-01-29 | 2019-03-05 | Advanced Animal Diagnostics, Inc. | Methods and compositions for detecting mycoplasma exposure |
WO2017147186A1 (en) | 2016-02-22 | 2017-08-31 | Ursure, Inc. | System and method for detecting therapeutic agents to monitor adherence to a treatment regimen |
EP3309154A1 (en) | 2016-10-13 | 2018-04-18 | Universite De Geneve | New compounds and uses thereof for detection of target molecules in a sample |
WO2018203145A1 (en) | 2017-05-03 | 2018-11-08 | Oslo Universitetssykehus Hf | Systems and methods for monitoring biological fluids |
AU2018337028A1 (en) | 2017-09-21 | 2020-04-09 | Becton, Dickinson And Company | Sampling systems and techniques to collect hazardous contaminants with high pickup and shedding efficiencies |
JP7277442B2 (en) | 2017-09-21 | 2023-05-19 | ベクトン・ディキンソン・アンド・カンパニー | Augmented Reality Device for Hazardous Pollutant Testing |
CN209559735U (en) | 2017-09-21 | 2019-10-29 | 贝克顿·迪金森公司 | For guiding the system for collecting noxious pollutant sample |
WO2019060269A1 (en) | 2017-09-21 | 2019-03-28 | Becton, Dickinson And Company | Hazardous contaminant collection kit and rapid testing |
JP7206257B2 (en) | 2017-09-21 | 2023-01-17 | ベクトン・ディキンソン・アンド・カンパニー | Hazardous contaminant collection kits and rapid tests |
JP7223749B2 (en) * | 2017-09-21 | 2023-02-16 | ベクトン・ディキンソン・アンド・カンパニー | High dynamic range analyzer for testing hazardous contaminants |
US11002642B2 (en) | 2017-09-21 | 2021-05-11 | Becton, Dickinson And Company | Demarcation template for hazardous contaminant testing |
WO2020005947A2 (en) * | 2018-06-25 | 2020-01-02 | Vascu Technology, Inc. | Methods and kits for detection of 11-dehydro-thromboxane b2 |
AU2020215639A1 (en) | 2019-01-28 | 2021-08-05 | Becton, Dickinson And Company | Hazardous contaminant collection device with integrated swab and test device |
US11300576B2 (en) | 2019-01-29 | 2022-04-12 | Arizona Board Of Regents On Behalf Of Arizona State University | DARPin reagents that distinguish Alzheimer's disease and Parkinson's disease samples |
WO2020245653A1 (en) | 2019-06-04 | 2020-12-10 | Alere Toxicology Plc | Fluid specimen testing |
EP4136449A1 (en) | 2020-04-16 | 2023-02-22 | Senova Gesellschaft für Biowissenschaft und Technik mbH | Lateral flow assay |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0259157A1 (en) * | 1986-09-05 | 1988-03-09 | Syntex (U.S.A.) Inc. | Immunoseparating strip |
EP0303110A2 (en) * | 1987-08-14 | 1989-02-15 | Boehringer Mannheim Italia S.P.A. | Immunodiagnostic device and method |
US4806311A (en) * | 1985-08-28 | 1989-02-21 | Miles Inc. | Multizone analytical element having labeled reagent concentration zone |
EP0363942A2 (en) * | 1988-10-12 | 1990-04-18 | Roche Diagnostics GmbH | Method for the determination of a specific binding substance |
EP0407904A2 (en) * | 1989-07-12 | 1991-01-16 | Roche Diagnostics GmbH | Method for the determination of an analyte |
US5451504A (en) * | 1991-07-29 | 1995-09-19 | Serex, Inc. | Method and device for detecting the presence of analyte in a sample |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4740468A (en) * | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
CA1303983C (en) * | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
US5137808A (en) * | 1987-04-07 | 1992-08-11 | Syntex (U.S.A.) Inc. | Immunoassay device |
US5229073A (en) * | 1992-02-27 | 1993-07-20 | Abbott Laboratories | One-step competitive immunoassay for the semiquantitative determination of plasma lipoprotein(a) |
-
1996
- 1996-09-25 US US08/719,221 patent/US5798273A/en not_active Expired - Lifetime
-
1997
- 1997-09-16 CA CA002215619A patent/CA2215619A1/en not_active Abandoned
- 1997-09-25 EP EP97307508A patent/EP0833159A3/en not_active Withdrawn
- 1997-09-25 JP JP27805997A patent/JP3174543B2/en not_active Expired - Fee Related
- 1997-09-25 AU AU39238/97A patent/AU3923897A/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4806311A (en) * | 1985-08-28 | 1989-02-21 | Miles Inc. | Multizone analytical element having labeled reagent concentration zone |
EP0259157A1 (en) * | 1986-09-05 | 1988-03-09 | Syntex (U.S.A.) Inc. | Immunoseparating strip |
EP0303110A2 (en) * | 1987-08-14 | 1989-02-15 | Boehringer Mannheim Italia S.P.A. | Immunodiagnostic device and method |
EP0363942A2 (en) * | 1988-10-12 | 1990-04-18 | Roche Diagnostics GmbH | Method for the determination of a specific binding substance |
EP0407904A2 (en) * | 1989-07-12 | 1991-01-16 | Roche Diagnostics GmbH | Method for the determination of an analyte |
US5451504A (en) * | 1991-07-29 | 1995-09-19 | Serex, Inc. | Method and device for detecting the presence of analyte in a sample |
Non-Patent Citations (6)
Title |
---|
Clark M.: Antibody-Antigen Reactions * |
Displacement: An incubatin-step-free, quantittive immunological method for applications in flow systems * |
L{nge K. et al: 'Extended Working Range for Binding Inhibition Type-Immunoprobes', Sep. 2003 * |
Loor R. et al: Boehringer Mannheim Cedia Digoxin Assay * |
Measurement of Antibody Affinity or Avidity * |
Thermodynamics of Antigen-Antibody Interaction * |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000042434A1 (en) * | 1999-01-09 | 2000-07-20 | Bernd Pevec | Method and device for determining an analyte |
US7041787B2 (en) | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases |
US7651841B2 (en) | 2001-12-24 | 2010-01-26 | Kimberly-Clark Worldwide, Inc. | Polyelectrolytic internal calibration system of a flow-through assay |
WO2003058220A1 (en) * | 2001-12-24 | 2003-07-17 | Kimberly-Clark Worldwide, Inc. | Reading device, method, and system for conducting lateral flow assays |
US8137985B2 (en) | 2001-12-24 | 2012-03-20 | Kimberly-Clark Worldwide, Inc. | Polyelectrolytic internal calibration system of a flow-through assay |
US7670786B2 (en) | 2002-08-27 | 2010-03-02 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
US7662643B2 (en) | 2002-12-19 | 2010-02-16 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in membrane-based assay devices |
US7851209B2 (en) | 2003-04-03 | 2010-12-14 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in assay devices |
US7829328B2 (en) | 2003-04-03 | 2010-11-09 | Kimberly-Clark Worldwide, Inc. | Assay devices that utilize hollow particles |
US8034397B2 (en) | 2003-04-03 | 2011-10-11 | Kimberly-Clark Worldwide, Inc. | Methods of making assay devices utilizing hollow particles |
WO2005057215A1 (en) * | 2003-11-21 | 2005-06-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based lateral flow assay devices that utilize phosphorescent detection |
GB2439256A (en) * | 2005-05-04 | 2007-12-19 | Lateral Lab Ltd | Liquid flow assays utilising a combined detection and control zone |
WO2006117574A3 (en) * | 2005-05-04 | 2007-01-04 | Lateral Lab Ltd | Liquid flow assays utilising a combined detection and control zone |
US7749776B2 (en) | 2005-05-04 | 2010-07-06 | Lateral Laboratories Limited | Liquid flow assays utilising a combined detection and control zone |
WO2006117574A2 (en) * | 2005-05-04 | 2006-11-09 | Lateral Laboratories Limited | Liquid flow assays utilising a combined detection and control zone |
CN106442973A (en) * | 2016-09-07 | 2017-02-22 | 北京热景生物技术股份有限公司 | Fungaltoxin multi-parameter quantitative detection kit in field of food security |
Also Published As
Publication number | Publication date |
---|---|
JP3174543B2 (en) | 2001-06-11 |
AU3923897A (en) | 1998-04-02 |
CA2215619A1 (en) | 1998-03-25 |
EP0833159A3 (en) | 1998-08-12 |
US5798273A (en) | 1998-08-25 |
JPH10160736A (en) | 1998-06-19 |
MX9706654A (en) | 1998-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5798273A (en) | Direct read lateral flow assay for small analytes | |
US5998221A (en) | Non-instrumented assay with quantitative and qualitative results | |
US6194220B1 (en) | Non-instrumented assay with quantitative and qualitative results | |
CA2099433C (en) | Enhancement of signal in immunoassays using microparticles which contain different detectable substances | |
EP0154749A1 (en) | Solid phase immunoassay with visual readout | |
EP0291176B1 (en) | Solid phase assay employing capillary flow | |
EP0284232B1 (en) | Solid phase assay | |
US5073340A (en) | Depositing a binder on a solid support | |
US4743560A (en) | Solid phase assay | |
USRE38430E1 (en) | Solid phase chromatographic immunoassay | |
US6057165A (en) | Quality control procedure for membrane flow-through diagnostic assay devices | |
DE69635607T2 (en) | LIPOSOM-REINFORCED IMMUNOAGGREGATION TEST AND TEST DEVICE | |
DE69936916T2 (en) | LIGANDEN BINDING TEST AND KIT WITH A SEPARATION ZONE FOR DISTURBING SAMPLE COMPONENTS | |
DE4037724C2 (en) | Devices for immunoassays and their materials | |
US4605630A (en) | Large-liposome agglutination reagent and method | |
DE60316471T2 (en) | SELF-CALIBRATING FLOW TESTING DEVICES | |
US5567591A (en) | Amplified assay for analyte | |
Rongen et al. | Development of a liposome immunosorbent assay for human interferon-y | |
EP0302673B1 (en) | system and process for a visible assay for analyte | |
US5204061A (en) | Depositing a binder on a solid support | |
US5260025A (en) | Depositing a binder on a solid support | |
CA1340069C (en) | Depositing a binder on a solid support | |
MXPA97006654A (en) | Side flow reading for direct reading for elements to be analyzed small |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): DE ES FR GB IT |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;RO;SI |
|
PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
|
AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;RO;SI |
|
17P | Request for examination filed |
Effective date: 19990209 |
|
AKX | Designation fees paid |
Free format text: DE ES FR GB IT |
|
RBV | Designated contracting states (corrected) |
Designated state(s): DE ES FR GB IT |
|
17Q | First examination report despatched |
Effective date: 20020722 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: MILLIPORE CORPORATION |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: MILLIPORE CORPORATION |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20040413 |