EP0804181A4 - Method and composition for treating mammalian diseases caused by inflammatory response - Google Patents

Method and composition for treating mammalian diseases caused by inflammatory response

Info

Publication number: EP0804181A4
Authority: EP; European Patent Office
Prior art keywords: composition; inflammatory response; diseases caused; treating mammalian; mammalian diseases
Prior art date: 1995-09-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP96929932A

Other languages

German (de)

French (fr)

Other versions

EP0804181A1 (en

Inventor

Stanley E Katz

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cellular Sciences Inc

Original Assignee

Cellular Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-19

Filing date

1996-09-06

Publication date

2005-02-02

1996-09-06 Application filed by Cellular Sciences Inc filed Critical Cellular Sciences Inc

1997-11-05 Publication of EP0804181A1 publication Critical patent/EP0804181A1/en

2005-02-02 Publication of EP0804181A4 publication Critical patent/EP0804181A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

EP96929932A 1995-09-19 1996-09-06 Method and composition for treating mammalian diseases caused by inflammatory response Withdrawn EP0804181A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US396295P	1995-09-19	1995-09-19
PCT/US1996/014304 WO1997010818A1 (en)	1995-09-19	1996-09-06	Method and composition for treating mammalian diseases caused by inflammatory response

Publications (2)

Publication Number	Publication Date
EP0804181A1 EP0804181A1 (en)	1997-11-05
EP0804181A4 true EP0804181A4 (en)	2005-02-02

Family

ID=21708422

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP96929932A Withdrawn EP0804181A4 (en)	1995-09-19	1996-09-06	Method and composition for treating mammalian diseases caused by inflammatory response

Country Status (10)

Country	Link
EP (1)	EP0804181A4 (en)
JP (1)	JP4459303B2 (en)
AU (1)	AU719332B2 (en)
CA (1)	CA2205112C (en)
IL (1)	IL119225A (en)
MX (1)	MX9703653A (en)
NZ (1)	NZ306832A (en)
TW (1)	TW434012B (en)
WO (1)	WO1997010818A1 (en)
ZA (1)	ZA967833B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2373611C (en) *	1999-05-14	2009-06-23	Cellular Sciences, Inc.	Method and composition for treating mammalian nasal and sinus diseases caused by inflammatory response
EP1379230A4 (en) *	2001-03-15	2009-01-21	Univ Pittsburgh	Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions
US6623723B2 (en) *	2001-08-21	2003-09-23	Cellular Sciences Inc.	Method for treating bronchial constriction and bronchospasm
US6689810B2 (en) *	2001-08-21	2004-02-10	Cellular Sciences, Inc.	Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide
US20030105162A1 (en) *	2001-08-21	2003-06-05	Celluar Sciences, Inc.	Method for treating bronchial constriction and bronchospasm
US8076373B2 (en) *	2001-09-11	2011-12-13	North Cell Pharmacetical	Method for treating mammalian diseases and injuries caused by the over-expression of peroxynitrite
WO2009116546A1 (en) *	2008-03-18	2009-09-24	国立大学法人岡山大学	Excitatory chemical mediator and method for screening thereof
US11571455B2 (en)	2013-04-11	2023-02-07	Vanderbilt University	Methods and compositions for treating alcoholic liver disease
US11771739B2 (en)	2017-06-16	2023-10-03	Vanderbilt University	Methods and compositions for treating microbial inflammation
EP3797766A1 (en) *	2019-09-24	2021-03-31	Evonik Operations GmbH	Compositions for use in reducing inflammation
WO2021094341A1 (en) *	2019-11-14	2021-05-20	Merck Patent Gmbh	Cell culture media

Citations (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1857M (en) *	1962-03-08	1963-06-10	Roussel Uclaf	New drug in particular for the treatment of diseases of viral origin.
US3279997A (en) *	1963-10-22	1966-10-18	Herbert D Schneyer	Enteric coated calcium lactate tablets containing an antihistamine and thiamine chloride
US3920835A (en) *	1973-09-04	1975-11-18	Scott Eugene J Van	Treatment of disturbed keratinization
US3988470A (en) *	1974-02-25	1976-10-26	Scott Eugene J Van	Treatment of palmar and plant disturbed keratosis
US4105783A (en) *	1975-07-23	1978-08-08	Yu Ruey J	Therapeutic treatment of dry skin
US4158057A (en) *	1975-03-28	1979-06-12	Stanko Ronald T	Prevention of the accumulation of fatty deposits in the liver
US4197316A (en) *	1975-07-23	1980-04-08	Scott Eugene J Van	Treatment of dry skin
US4234599A (en) *	1978-10-04	1980-11-18	Scott Eugene J Van	Treatment of skin keratoses with α-hydroxy acids and related compounds
US4351835A (en) *	1981-04-01	1982-09-28	Montefiore Hospital	Method for preventing body fat deposition in mammals
US4415576A (en) *	1981-04-01	1983-11-15	Montefiore Hospital	Method for preventing body fat deposition in mammals
DE3302694A1 (en) *	1983-01-27	1984-08-02	Retheto Filmtechnik Theilemann & Co, 8000 München	ORAL CARE PRODUCTS
US4521375A (en) *	1982-11-23	1985-06-04	Coopervision, Inc.	Sterilizing treatment with hydrogen peroxide and neutralization of residual amounts thereof
US4663166A (en) *	1984-06-22	1987-05-05	Veech Richard L	Electrolyte solutions and in vivo use thereof
US4696917A (en) *	1985-08-01	1987-09-29	Lindstrom Richard L	Irrigation solution
JPS63135370A (en) *	1986-11-26	1988-06-07	Grelan Pharmaceut Co Ltd	Antiallergic agent
EP0315467A2 (en) *	1987-11-06	1989-05-10	LyphoMed, Inc.	Pentamidine salts useful in the treatment and prophylaxis of pneumocystis carinii pneumonia
WO1990000900A1 (en) *	1988-07-20	1990-02-08	Amgen Inc.	Method of treating inflammatory disorders by reducing phagocyte activation
JPH02124824A (en) *	1988-11-02	1990-05-14	Eisai Co Ltd	Preparation for percutaneous application containing azelastine or slat thereof
WO1991015223A1 (en) *	1990-03-30	1991-10-17	Amgen Inc.	Respiratory burst suppression factor
US5210098A (en) *	1990-09-21	1993-05-11	Regents Of The University Of Minnesota	Use of pyruvate to treat acute renal failure
WO1993016690A1 (en) *	1992-02-25	1993-09-02	Warner-Lambert Company	Cytoprotective compositions containing pyruvate and antioxidants
US5256697A (en) *	1992-04-16	1993-10-26	Abbott Laboratories	Method of administering pyruvate and methods of synthesizing pyruvate precursors
JPH05306218A (en) *	1992-04-27	1993-11-19	Kao Corp	Bronchodilator
US5296370A (en) *	1990-10-04	1994-03-22	Rutgers, The State University	Repair medium for the resuscitation of injured cells
WO1996000584A1 (en) *	1994-06-30	1996-01-11	Warner-Lambert Company	Anti-inflammatory wound healing compositions and methods for preparing and using same
US5536751A (en) *	1994-05-09	1996-07-16	The United States Of America As Represented By The Secretary Of The Army	Pharmaceutical alpha-keto carboxylic acid compositions method of making and use thereof

1996
- 1996-09-06 AU AU69159/96A patent/AU719332B2/en not_active Ceased
- 1996-09-06 EP EP96929932A patent/EP0804181A4/en not_active Withdrawn
- 1996-09-06 WO PCT/US1996/014304 patent/WO1997010818A1/en active Application Filing
- 1996-09-06 NZ NZ306832A patent/NZ306832A/en not_active IP Right Cessation
- 1996-09-06 JP JP51274197A patent/JP4459303B2/en not_active Expired - Lifetime
- 1996-09-06 MX MX9703653A patent/MX9703653A/en unknown
- 1996-09-06 CA CA002205112A patent/CA2205112C/en not_active Expired - Lifetime
- 1996-09-09 IL IL11922596A patent/IL119225A/en not_active IP Right Cessation
- 1996-09-17 ZA ZA967833A patent/ZA967833B/en unknown
- 1996-09-18 TW TW085111379A patent/TW434012B/en not_active IP Right Cessation

Patent Citations (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1857M (en) *	1962-03-08	1963-06-10	Roussel Uclaf	New drug in particular for the treatment of diseases of viral origin.
US3279997A (en) *	1963-10-22	1966-10-18	Herbert D Schneyer	Enteric coated calcium lactate tablets containing an antihistamine and thiamine chloride
US3920835A (en) *	1973-09-04	1975-11-18	Scott Eugene J Van	Treatment of disturbed keratinization
US3988470A (en) *	1974-02-25	1976-10-26	Scott Eugene J Van	Treatment of palmar and plant disturbed keratosis
US4158057A (en) *	1975-03-28	1979-06-12	Stanko Ronald T	Prevention of the accumulation of fatty deposits in the liver
US4105783A (en) *	1975-07-23	1978-08-08	Yu Ruey J	Therapeutic treatment of dry skin
US4197316A (en) *	1975-07-23	1980-04-08	Scott Eugene J Van	Treatment of dry skin
US4234599A (en) *	1978-10-04	1980-11-18	Scott Eugene J Van	Treatment of skin keratoses with α-hydroxy acids and related compounds
US4351835A (en) *	1981-04-01	1982-09-28	Montefiore Hospital	Method for preventing body fat deposition in mammals
US4415576A (en) *	1981-04-01	1983-11-15	Montefiore Hospital	Method for preventing body fat deposition in mammals
US4521375A (en) *	1982-11-23	1985-06-04	Coopervision, Inc.	Sterilizing treatment with hydrogen peroxide and neutralization of residual amounts thereof
DE3302694A1 (en) *	1983-01-27	1984-08-02	Retheto Filmtechnik Theilemann & Co, 8000 München	ORAL CARE PRODUCTS
US4663166A (en) *	1984-06-22	1987-05-05	Veech Richard L	Electrolyte solutions and in vivo use thereof
US4696917A (en) *	1985-08-01	1987-09-29	Lindstrom Richard L	Irrigation solution
US4725586A (en) *	1985-08-01	1988-02-16	Lindstrom Richard L	Surgical solution
JPS63135370A (en) *	1986-11-26	1988-06-07	Grelan Pharmaceut Co Ltd	Antiallergic agent
EP0315467A2 (en) *	1987-11-06	1989-05-10	LyphoMed, Inc.	Pentamidine salts useful in the treatment and prophylaxis of pneumocystis carinii pneumonia
WO1990000900A1 (en) *	1988-07-20	1990-02-08	Amgen Inc.	Method of treating inflammatory disorders by reducing phagocyte activation
JPH02124824A (en) *	1988-11-02	1990-05-14	Eisai Co Ltd	Preparation for percutaneous application containing azelastine or slat thereof
WO1991015223A1 (en) *	1990-03-30	1991-10-17	Amgen Inc.	Respiratory burst suppression factor
US5210098A (en) *	1990-09-21	1993-05-11	Regents Of The University Of Minnesota	Use of pyruvate to treat acute renal failure
US5296370A (en) *	1990-10-04	1994-03-22	Rutgers, The State University	Repair medium for the resuscitation of injured cells
WO1993016690A1 (en) *	1992-02-25	1993-09-02	Warner-Lambert Company	Cytoprotective compositions containing pyruvate and antioxidants
US5256697A (en) *	1992-04-16	1993-10-26	Abbott Laboratories	Method of administering pyruvate and methods of synthesizing pyruvate precursors
JPH05306218A (en) *	1992-04-27	1993-11-19	Kao Corp	Bronchodilator
US5536751A (en) *	1994-05-09	1996-07-16	The United States Of America As Represented By The Secretary Of The Army	Pharmaceutical alpha-keto carboxylic acid compositions method of making and use thereof
WO1996000584A1 (en) *	1994-06-30	1996-01-11	Warner-Lambert Company	Anti-inflammatory wound healing compositions and methods for preparing and using same

Non-Patent Citations (25)

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Title
ACTA OTO-LARYNGOLOGICA. SUPPLEMENTUM. 1994, vol. 515, 1994, pages 18 - 21, ISSN: 0365-5237 *
BÜNGER R ET AL: "Pyruvate attenuation of hypoxia damage in isolated working guinea-pig heart.", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. APR 1986, vol. 18, no. 4, April 1986 (1986-04-01), pages 423 - 438, XP008039899, ISSN: 0022-2828 *
COHEN J ET AL: "Pregnancies following the frozen storage of expanding human blastocysts.", JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER : IVF. JUN 1985, vol. 2, no. 2, June 1985 (1985-06-01), pages 59 - 64, XP008039916, ISSN: 0740-7769 *
COHEN M H: "Cure of advanced L1210 leukemia after correction of abnormal red blood cell deformability.", CANCER CHEMOTHERAPY AND PHARMACOLOGY. 1981, vol. 5, no. 3, 1981, pages 175 - 179, XP008039915, ISSN: 0344-5704 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1994, WESTRIN K M ET AL: "Microorganisms and leukocytes in purulent sinusitis: a symbiotic relationship in metabolism.", XP002309523, Database accession no. NLM8067237 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; January 1986 (1986-01-01), PINE L ET AL: "Role of keto acids and reduced-oxygen-scavenging enzymes in the growth of Legionella species.", XP002309522, Database accession no. NLM3009529 *
DATABASE WPI Section Ch Week 198828, Derwent World Patents Index; Class B03, AN 1988-195837, XP002296174 *
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GIANNELLI S JR ET AL: "Prevention of increased hemoglobin-oxygen affinity in open-heart operations with inosine-phosphate-pyruvate solution.", THE ANNALS OF THORACIC SURGERY. MAY 1976, vol. 21, no. 5, May 1976 (1976-05-01), pages 386 - 396, XP008039903, ISSN: 0003-4975 *
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MENTZER R M JR ET AL: "Effect of pyruvate on regional ventricular function in normal and stunned myocardium.", ANNALS OF SURGERY. MAY 1989, vol. 209, no. 5, May 1989 (1989-05-01), pages 629 - 633 ; dis, XP008039900, ISSN: 0003-4932 *
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MOCHIZUKI S ET AL: "Energy metabolism during reperfusion following ischemia.", JOURNAL DE PHYSIOLOGIE. 1980, vol. 76, no. 7, 1980, pages 805 - 812, XP008039901, ISSN: 0021-7948 *
O'DONNELL-TORMEY J ET AL: "Secretion of pyruvate. An antioxidant defense of mammalian cells.", THE JOURNAL OF EXPERIMENTAL MEDICINE. 1 FEB 1987, vol. 165, no. 2, 1 February 1987 (1987-02-01), pages 500 - 514, XP002309326, ISSN: 0022-1007 *
OGAWA Y ET AL: "Comparative study of the effects of pyruvate and CG-120 in preventing experimental oxalate urolithiasis in rats.", HINYOKIKA KIYO. ACTA UROLOGICA JAPONICA. SEP 1986, vol. 32, no. 9, September 1986 (1986-09-01), pages 1341 - 1347, XP008039912, ISSN: 0018-1994 *
PUSCHMANN M ET AL: "[Double-blind controlled gastroscopic comparative study on lesions of the gastric mucosa in healthy volunteers after treatment with acetylsalicylic acid or acetylsalicylic acid/sodium pyruvate]", ARZNEIMITTEL-FORSCHUNG. 1983, vol. 33, no. 3, 1983, pages 415 - 416, XP008039938, ISSN: 0004-4172 *
PUSCHMANN M: "[Animal experiments on the gastric mucosa and demonstration of analgesic and antipyretic effects after combined administration of acetylsalicylic acid and sodium pyruvate]", ARZNEIMITTEL-FORSCHUNG. 1983, vol. 33, no. 3, 1983, pages 410 - 415, XP008039937, ISSN: 0004-4172 *
REGITZ V ET AL: "Biochemical mechanism of infarct size reduction by pyruvate.", CARDIOVASCULAR RESEARCH. NOV 1981, vol. 15, no. 11, November 1981 (1981-11-01), pages 652 - 658, XP008039902, ISSN: 0008-6363 *
SABRI M I ET AL: "EFFECT OF EXOGENOUS PYRUVATE ON ACRYLAMIDE NEUROPATHY IN RATS", BRAIN RESEARCH, AMSTERDAM, NL, vol. 483, no. 1, 1989, pages 1 - 11, XP001190880, ISSN: 0006-8993 *
SCHWARTZ C ET AL: "Antagonism of cyanide intoxication with sodium pyruvate.", TOXICOLOGY AND APPLIED PHARMACOLOGY. 30 SEP 1979, vol. 50, no. 3, 30 September 1979 (1979-09-30), pages 437 - 441, XP008039904, ISSN: 0041-008X *
See also references of WO9710818A1 *
SHACTER E: "Serum-free medium for growth factor-dependent and -independent plasmacytomas and hybridomas.", JOURNAL OF IMMUNOLOGICAL METHODS. 20 MAY 1987, vol. 99, no. 2, 20 May 1987 (1987-05-20), pages 259 - 270, XP008039984, ISSN: 0022-1759 *

Also Published As

Publication number	Publication date
TW434012B (en)	2001-05-16
NZ306832A (en)	2001-04-27
ZA967833B (en)	1997-06-02
AU719332B2 (en)	2000-05-04
MX9703653A (en)	1998-07-31
AU6915996A (en)	1997-04-09
JP4459303B2 (en)	2010-04-28
IL119225A (en)	2000-09-28
EP0804181A1 (en)	1997-11-05
CA2205112A1 (en)	1997-03-27
WO1997010818A1 (en)	1997-03-27
IL119225A0 (en)	1996-12-05
JPH10509463A (en)	1998-09-14
CA2205112C (en)	2008-11-18

Legal Events

Date	Code	Title	Description
1997-09-19	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1997-11-05	17P	Request for examination filed	Effective date: 19970912
1997-11-05	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2004-11-03	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61P 11/00 B Ipc: 7A 61K 31/16 B Ipc: 7A 61K 31/047 B Ipc: 7A 61K 31/12 B Ipc: 7A 61K 31/195 B Ipc: 7A 61K 31/19 A
2005-02-02	A4	Supplementary search report drawn up and despatched	Effective date: 20041221
2013-10-11	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2013-11-13	18D	Application deemed to be withdrawn	Effective date: 20130403

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