EP0750630A4 - Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains - Google Patents

Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains

Info

Publication number
EP0750630A4
EP0750630A4 EP95914721A EP95914721A EP0750630A4 EP 0750630 A4 EP0750630 A4 EP 0750630A4 EP 95914721 A EP95914721 A EP 95914721A EP 95914721 A EP95914721 A EP 95914721A EP 0750630 A4 EP0750630 A4 EP 0750630A4
Authority
EP
European Patent Office
Prior art keywords
domains
materials
methods
molecular interactions
identifying inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95914721A
Other languages
German (de)
French (fr)
Other versions
EP0750630A1 (en
Inventor
Richard J Rickles
Joan S Brugge
Martyn C Botfield
Mark J Zoller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ariad Pharmaceuticals Inc
Original Assignee
Ariad Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ariad Pharmaceuticals Inc filed Critical Ariad Pharmaceuticals Inc
Publication of EP0750630A1 publication Critical patent/EP0750630A1/en
Publication of EP0750630A4 publication Critical patent/EP0750630A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/72—Fusion polypeptide containing domain for protein-protein interaction containing SH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
EP95914721A 1994-03-11 1995-03-13 Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains Withdrawn EP0750630A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20983594A 1994-03-11 1994-03-11
US209835 1994-03-11
US36983295A 1995-01-06 1995-01-06
US369832 1995-01-06
PCT/US1995/003208 WO1995024419A1 (en) 1994-03-11 1995-03-13 Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains

Publications (2)

Publication Number Publication Date
EP0750630A1 EP0750630A1 (en) 1997-01-02
EP0750630A4 true EP0750630A4 (en) 1998-01-07

Family

ID=26904553

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95914721A Withdrawn EP0750630A4 (en) 1994-03-11 1995-03-13 Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains

Country Status (3)

Country Link
EP (1) EP0750630A4 (en)
AU (1) AU2159895A (en)
WO (1) WO1995024419A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184205B1 (en) * 1994-07-22 2001-02-06 University Of North Carolina At Chapel Hill GRB2 SH3 binding peptides and methods of isolating and using same
AU3146095A (en) * 1994-07-22 1996-02-22 University Of North Carolina At Chapel Hill, The Src sh3 binding peptides and methods of isolating and using same
US6303574B1 (en) 1994-07-22 2001-10-16 The University Of North Carolina At Chapel Hill Scr SH3 binding peptides and methods of isolating and using same
US5888763A (en) * 1994-12-30 1999-03-30 The Rockefeller University Peptides specific for the first Crk-SH3 domain
EP0833941B1 (en) 1995-04-07 2008-10-22 Cytogen Corporation Polypeptides having a functional domain of interest and methods of identifying and using same
US6309820B1 (en) 1995-04-07 2001-10-30 University Of North Carolina At Chapel Hill Polypeptides having a functional domain of interest and methods of identifying and using same
GB2311067B (en) * 1996-01-08 2000-03-29 Yamanouchi U K Ltd Proline rich peptides derived from the rasgap-associated protein P62
US6303319B1 (en) * 1996-02-23 2001-10-16 Ariad Pharmaceuticals, Inc. Cell based assay for identifying sh2-domain-specific signal transducer antagonist
US7279548B2 (en) 1996-04-03 2007-10-09 Cytogen Corporation Identification and isolation of novel polypeptides having WW domains and methods of using same
ATE224454T1 (en) * 1996-04-26 2002-10-15 Massachusetts Inst Technology THREE HYBRID SCREENING TEST
US6723694B1 (en) 1997-05-21 2004-04-20 The Children's Medical Center Corp. Short peptides which selectively modulate intracellular signalling
JP2002516338A (en) * 1998-05-21 2002-06-04 マクギル ユニバーシティー Agents as inhibitors of cell migration and / or focal adhesion that interfere with the binding of protein tyrosine phosphatase PEST to signal proteins
JP2003500080A (en) 1999-05-26 2003-01-07 リセンチア エルテーデー Methods and materials for producing SH3 domains with designed binding capacity
US20020002239A1 (en) * 1999-12-29 2002-01-03 Tanaka Richard D. Binding of polyamides to proteins having SH3 or WW domains
EP1432729B1 (en) * 2001-07-02 2008-11-12 Merrion Research III Limited Peyers's patch and/or m-cell targeting ligands
US7179784B2 (en) * 2001-07-10 2007-02-20 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
AU2003258022A1 (en) 2002-08-02 2004-02-23 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
WO2004039318A2 (en) 2002-10-25 2004-05-13 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
CA2508769A1 (en) 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
ATE485303T1 (en) 2003-06-20 2010-11-15 Mayo Foundation ISOFORMS OF BRAIN NATRIURETIC PEPTIDE
WO2008021872A1 (en) 2006-08-08 2008-02-21 Mayo Foundation For Medical Education And Research Diuretic and natriuretic polypeptides
CA2697413A1 (en) * 2007-08-24 2009-03-05 Mylexa Pty Limited Modulators of hypersensitivity reactions
US8357656B2 (en) 2007-09-15 2013-01-22 Mayo Foundation For Medical Education And Research Natriuretic peptide receptor-C agonists
US8088890B2 (en) * 2008-09-26 2012-01-03 Fibrex Medical Research & Development Gmbh Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition
CN103906761B (en) 2011-08-30 2016-12-21 梅约医学教育与研究基金会 Profit sodium polypeptide
US9611305B2 (en) 2012-01-06 2017-04-04 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
EP2752196A1 (en) * 2013-01-03 2014-07-09 Université Bordeaux Segalen Selective nox-1 inhibitor peptides and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2054602A1 (en) * 1991-10-31 1993-05-01 Anthony Pawson Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
CA2054602A1 (en) * 1991-10-31 1993-05-01 Anthony Pawson Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GOUT, I. ET AL.: "Identification and functional characterization of SH3 domain-binding proteins", J. CELL BIOL., SUPPL. 0, (KEYSTONE SYMP. TRANSMEMB. SIG. TRANSDUCT., ISSN 0733-1959), vol. 18B, February 1994 (1994-02-01), pages 279, XP000652908 *
GOUT, I. ET AL.: "The GTPase dynamin binds to and is activated by a subset of SH3 domains", CELL, vol. 75, 1993, pages 25 - 36, XP000652048 *
LI, N. ET AL.: "Guanine-nucleotide-releasing factor hSos1 binds to Grb2 ...", NATURE, vol. 363, 1993, pages 85 - 88, XP002043217 *
REN, R. ET AL.: "Identification of a ten-amino acid proline.rich SH3 binding site", SCIENCE, vol. 259, 1993, pages 1157 - 1161, XP000652050 *
See also references of WO9524419A1 *

Also Published As

Publication number Publication date
AU2159895A (en) 1995-09-25
WO1995024419A1 (en) 1995-09-14
EP0750630A1 (en) 1997-01-02

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Inventor name: ZOLLER, MARK J.

Inventor name: BOTFIELD, MARTYN C.

Inventor name: BRUGGE, JOAN S.

Inventor name: RICKLES, RICHARD J.

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