EP0611596A1 - System for preparing liquids - Google Patents

Abstract

System for preparing liquids from at least one solid and from at least one liquid phase. The system comprises a vessel in which the solid or solids are situated and a dry chamber which is connected to the vessel or can be connected to the vessel. The dry chamber is separated from the vessel interior by a separating means which is permeable to water vapour but is impermeable to liquids. The system is suitable for the production of liquids from moisture-sensitive solids. These solids can be stored in the vessel, since the atmospheric humidity in the interior is decreased by the desiccant. The liquid can be prepared in one and the same vessel by addition of a liquid phase, since the desiccant is separated off from the vessel interior. <IMAGE>

Description

The invention relates to a system for preparing liquids from at least one solid and at least one liquid phase, the system consisting of a storage vessel with the solid and a drying chamber with a desiccant. The invention also relates to a method for producing a solution, suspension or emulsion using the system according to the invention. The process includes the steps of storing a solid in the system, adding a liquid phase to the solid, and mixing to produce a solution, suspension or emulsion. In a preferred application, the system is used to prepare reagent solutions.

A common problem in laboratories is the preparation of solutions from liquids and moisture-sensitive solids. Many solids have a limited shelf life in the presence of water vapor because they decompose. The occurrence of this problem ranges from everyday examples, such as. B. the preparation of food from dry powder, the preparation of solutions in the chemical laboratory, up to clinical analysis solutions. In the latter case in particular, preparation of the solution from a solid and a liquid component is necessary shortly before use if the finished analytical solution has a limited shelf life.

In many cases, the existing problem is solved in that the moisture-sensitive solid is either pre-dried and packaged in a water vapor-tight manner or is packed together with hygroscopic substances for drying and keeping dry. To prepare the solution, a certain amount of the substance is weighed out and dissolved in a measured amount of liquid. The method is particularly imperfect for analytical solutions because the quantitative transfer of the solid into a vessel, the addition of a precisely defined amount of solvent and complete dissolution are difficult. Not only trained personnel are required for this process, but also complex laboratory equipment.

In so-called test kits, the user takes over the preparation of the liquid by preparing the analytical solution from the portioned, ie already weighed, solids by adding liquid according to a rule given by the manufacturer of the kit. Stirrers or mixers can reduce the solids from the user. In these cases, however, a transfer of solid matter to a vessel is necessary for dissolution. It follows from this that a defined amount of solid in the form of tablets, powders or granules has to be introduced into a vessel in order to produce a solution of a defined concentration. In a known reagent storage system (DE-40 39 580), the reagent is transferred from a special container into a mixing vessel by opening a chamber in which the reagent is located when it is screwed onto the vessel. To prepare a solution of a precisely defined concentration, the chamber must be rinsed. This makes laboratory personnel or a complex flushing device necessary.

The object of the invention is to simplify the production of liquids from moisture-sensitive solids and liquids by providing a vessel suitable for drying and keeping dry. In particular, the preparation of analysis solutions by untrained personnel, even under conditions of poor infrastructure, should be made easier.

The task is achieved with the system for the preparation of a liquid from at least one solid and at least one liquid phase by the combination
a vessel which contains the at least one solid and has a volume which is sufficient to hold the at least one solid and the at least one liquid phase,
a desiccant chamber containing a desiccant (TM)
and a separating element, which closes the desiccant chamber,
that the desiccant can exchange water vapor with the contents of the vessel at any time, but the direct contact of a liquid or solid content of the vessel with the desiccant is essentially impossible.

• Ein Gefäß, in dem sich zunächst der Feststoff befindet und in dem die Auflösung des Feststoffes erfolgt.
• Eine an das Gefäß angeschlossene Trockenkammer, in der sich ein Trockenmittel befindet.

Accordingly, the task is solved by combining the following elements:

• A vessel in which the solid is initially and in which the solid is dissolved.
• A drying chamber connected to the vessel, in which there is a desiccant.

The solid of the solution to be prepared can be in various forms. These include powders, tablets, granules, pellets or freeze-dried lyophilisates.

A solution consisting of several substances can be prepared by using a solid consisting of several components. If the constituents in solution or in the presence of moisture are incompatible with one another, that is, if they then react with one another in an undesired manner, it is in many cases possible to store the substances together in a dry state without them reacting with one another. The storage stability of the solid is increased by a drying chamber that keeps the moisture in the interior of the vessel low. The presence of a desiccant in a chamber that can exchange water vapor with the interior of the vessel leads to a lowering of the water vapor partial pressure in the interior of the vessel. It is also possible to store solids which have residual moisture due to the manufacturing process in the system according to the invention for drying or to remove the residual moisture.

The liquid phase can consist of a pure substance (e.g. distilled water) or a mixture of several liquids. The liquid phase can also, for. B. contain buffers, stabilizers or other solutes, so that the stability of the liquid produced is increased and its functioning is ensured.

To produce the liquid, the liquid phase is added to the solid in the vessel. This can be done either manually or automatically by a device. In cases where the liquid produced does not have to have an exact concentration, because a wide range of reagent concentrations leads to the same analysis results, the dimensioning of the liquid phase can, for. B. done by markings on the vessel wall. For example, enzymes can completely convert an analyte so that the result of the determination is largely independent of the enzyme concentration in the reagent. To produce a standard solution suitable for titration analysis, on the other hand, it is necessary to add a defined amount of liquid phase, characterized by its volume or weight, to a defined amount of solids. The solution is prepared by manual or mechanical mixing of the solid and the liquid phase. For a large number of analysis solutions, it is possible to standardize their preparation. In these embodiments, the liquid phase already contains further components, e.g. B. buffers and auxiliaries, so that one and the same liquid phase can always be used for many different analytical solutions.

The liquids produced from solid and liquid phase in the system according to the invention can be solutions, suspensions or emulsions. For example, an emulsion for the detection of the enzyme lipase can be prepared by adding water to a solid which contains the following substances: tris (hydroxymethyl) aminomethane (tris), sodium deoxycholate, CaCl₂, triolein, colipase, NaN₃.

According to the invention, the system includes a vessel and a drying chamber which are separated by a separating layer which prevents liquid from penetrating into the drying agent. The interface therefore fulfills two contradictory conditions. On the one hand, it is permeable to water vapor and thus enables the transfer of water from the interior of the vessel into the drying chamber via the gas phase, on the other hand it has a barrier effect for water in the condensed phase. This simplifies the manufacturing process in that the solution can be prepared in the same vessel in which the moisture-sensitive solid was previously stored. In a preferred embodiment, the solid is poured into the vessel during the manufacture of the system. In this case, the user does not need to transfer the solid into the vessel. Furthermore, this eliminates the problem that any moisture-sensitive or even hygroscopic substances have to be weighed out and transferred by the user. The system manufacturer can fill the system under dry room conditions and using highly accurate scales. Even users without a laboratory can prepare adjusted analytical solutions from moisture-sensitive solids.

A particularly simple, safe and reliable handling is made possible by a preferred embodiment in which the solid is in a vessel which is large enough to take up the resulting solution. This vessel has a closure, e.g. B. a stopper or a screw cap, on which a desiccant chamber is attached so that the desiccant it contains can absorb water vapor from the interior of the vessel when the vessel is closed. In this embodiment, the Drying chamber both serve to dry and / or keep the solid dry, and can also be used as a closure in the preparation of liquids.

It is also possible to fix the drying chamber in the vessel and to use a separate component to close the vessel. In addition, embodiments are possible in which no possibility of opening by z. B. a screw cap or a lid is provided. In these embodiments, the solid and the drying chamber can already be introduced into the vessel during the manufacture of the vessel. The liquid phase can be used by the user z. B. can be filled into the vessel by injection with a cannula.

• Herkömmliche, zur Aufnahme von Flüssigkeiten konstruierte Gefäße können durch den erfindungsgemäßen Einsatz des Trockenstopfens auch für die Aufbewahrung und Rücktrocknung von feuchtigkeitsempfindlichen Feststoffen verwendet werden. Gefäß und Trockenmittelstopfen werden damit zu einer neuen funktionellen Einheit.
• Das System zur Zubereitung von Lösungen erlaubt das Befüllen zum Zwecke des Inverkehrbringens von feuchtigkeitsempfindlichen Füllgütern in nicht vollständig wasserdampfdichten Behältnissen.
• Feste Füllgüter können bei der Abfüllung eine durch die Produktion bedingte höhere mobile Feuchte aufweisen als für die Lagerung gewünscht ist. Mit dem erfindungsgemäßen System können solche Füllgüter auf eine, für die Haltbarkeit notwendige, minimale Restfeuchte zurückgetrocknet werden.
• Das Trennelement verbindet eine hohe Dampfdurchlässigkeit mit einer guten Sperrwirkung gegenüber Flüssigkeiten.

In the possible embodiments, the system according to the invention for the production of liquids offers solutions for problems with partly contradicting requirements.

• Conventional vessels designed to hold liquids can also be used for the storage and re-drying of moisture-sensitive solids by using the drying plug according to the invention. The container and desiccant plug thus become a new functional unit.
• The system for preparing solutions allows filling for the purpose of placing moisture-sensitive goods on the market in containers that are not completely watertight.
• Solid filling goods can have a higher mobile humidity due to production than is desired for storage. With the system according to the invention, such fillings can be dried back to a minimum residual moisture necessary for the durability.
• The separating element combines a high vapor permeability with a good barrier effect against liquids.

• Aufbewahrung eines Feststoffes im geschlossenen Gefäß.
• Öffnen des Systems, z. B. durch das Abschrauben eines Verschlusses.
• Einfüllen der flüssigen Phase in das Gefäß, das bereits den Feststoff enthält.
• Verschließen des Systems, z. B. durch das Aufschrauben eines Verschlusses.
• Vermischen von flüssiger Phase und Feststoff.

A method for producing liquids with the system according to the invention can be carried out in the following steps:

• Storage of a solid in a closed container.
• Open the system, e.g. B. by unscrewing a closure.
• Pour the liquid phase into the vessel that already contains the solid.
• Closing the system, e.g. B. by screwing on a closure.
• Mixing liquid phase and solid.

The filling of the vessel with liquid phase can be done manually or mechanically, the automatic filling of the vessel within an automatic analyzer being a preferred embodiment. The vessel can be closed with the closure belonging to the system, or but another closure. Both manual and automated procedures are also possible in this process step. In special embodiments of the method according to the invention, the step of closing the vessel can be saved if there is no leakage of liquid from the vessel during the mixing. This can e.g. B. can be achieved by stirring or suitable pivoting of the vessel. In the prior art, in addition to the mechanical stirrers with a rotor that is immersed in the liquid, so-called magnetic stirrers are known, among other things, in which a mostly rod-shaped magnet is located within the vessel, which is set in motion by a magnetic field. In addition, swivels are known, for example, for bacterial cultures, which mix the contents of a vessel without substances in the vessel escaping through an existing opening at the top of the vessel. If the mixing process is carried out with the vessel closed, the methods already mentioned are available. In addition, methods are possible in which the vessel can assume any position, as is usually the case with manual mixing. After the mixing process, the prepared liquid is present in the vessel. For this she can, for. B. by piercing the vessel with a cannula or by other devices provided in the vessel. Preferably, however, liquid is removed after the closure containing the desiccant has been removed through the opening in the vessel.

An advantage of the system according to the invention is that the storage vessel for the solid also serves as a vessel for mixing the solid with the liquid phase and can serve to store the prepared liquid without the desiccant chamber having to be closed or removed after the liquid phase has been added.

A further advantage of the system is that the seal containing the drying agent can be used both during storage of the solid and during storage of the prepared liquid and preferably even during the mixing of the solid with the liquid phase.

Figur 1:

Eine erfindungsgemäße Trockenmittelkammer mit Trockenmittel im Längsschnitt.

Figur 2:

Mögliche Ausführungsformen des Gefäßes (im Kreis angeordnet) und der Trockenmittelkammer (in der Mitte).

Figur 3:

Verfahrensschritte bei der Zubereitung einer Flüssigkeit mit dem erfindungsgemäßen System.

Figur 4:

Feuchtegehalt eines Feststoffes bei der Aufbewahrung in verschiedenen erfindungsgemäßen Systemen.

The invention is explained in more detail below with reference to figures:

Figure 1:

A desiccant chamber according to the invention with desiccant in longitudinal section.

Figure 2:

Possible embodiments of the vessel (arranged in a circle) and the desiccant chamber (in the middle).

Figure 3:

Process steps in the preparation of a liquid with the system according to the invention.

Figure 4:

Moisture content of a solid when stored in various systems according to the invention.

A preferred embodiment of the desiccant chamber is suitable due to its construction to close the vessel. Such a desiccant chamber is referred to below as a desiccant plug.

The drying agent stopper (1) in FIG. 1 is closed off from the outside by a wall (2). This can consist of a variety of materials, e.g. B. plastic, metal and cardboard. In the preferred case, however, the wall will consist of a plastic, since this material combines some advantageous properties. Plastics of sufficient wall thickness, preferably greater than 0.5 mm, have the property of separating the desiccant inside the stopper from the environment in such a way that moisture exchange between the environment and desiccant is possible to a small extent, but a significant consumption of the desiccant by external moisture is avoided. In addition, it is possible in a simple manner to bring plastic into molds which contain both a thread (3) and a space for the desiccant (4).

The desiccant (14) is inside the stopper. When choosing a suitable drying agent, the substances known from the specialist literature, such as molecular sieves, silica gel, sodium sulfate, calcium sulfate, etc., are available. A molecular sieve of the zeolite type suitable for the stated use is available from Grace GmbH under the name molecular sieve type 511. The amount of desiccant used and thus the drying capacity must be such that, if desired, a possible mobile moisture content of the solid is absorbed and that moisture which penetrates from outside can be absorbed until the solution is prepared. On the other hand, the amount of desiccant should be so small that when the liquid produced is stored in the preparation system there is no significant change in concentration due to the absorption of water by the desiccant from the solution. With preferred desiccant amounts in the range of a few grams and quantities of liquid in the range of deciliters, the error caused by the desiccant moves in a range acceptable for analytical solutions. In many cases, the liquid is used in an analytical apparatus soon after it has been prepared. In a preferred embodiment, the vessel is placed in a place provided within the apparatus without a desiccant plug. In this case, the liquid is only in direct or indirect contact with the desiccant plug while it is being prepared. The drying effect of the solution can therefore only be expected to a very small extent. The drying out effect can be prevented in all cases by exchanging the drying agent plug after the solid and liquid phase have been mixed with a closure without drying agent.

The separating element (6), which separates the desiccant and the interior of the vessel from one another, represents an essential aspect of the invention. The material of the separating element is such that it is permeable to water vapor, but completely blocks finished reagent solutions. In recent years, special plastics have been developed that combine these two properties (e.g. EP-A-0 500 173). However, other materials are also possible, such as. B. impregnated fabrics and cardboard. In a preferred embodiment of the invention, cardboard with a surface tension is used which prevents liquid from penetrating into the drying agent chamber and penetrating the drying agent with liquid. Suitable cartons are sold, for example, by Buchmann GmbH under the names GC1 and GC2 or by Laakmann GmbH under the names UD2. The water-repellent effect is primarily due to a Coating, the so-called line, which consists of pigments and synthetic binders. If the cardboard has a surface tension of less than 70 mN / m, the cardboard can no longer be wetted by water and penetration of water is in principle impossible, but water vapor is still permeable. For liquids that have a lower surface tension, a separating element with a lower surface tension is also necessary to prevent the penetration of liquids. The surface tension of the cardboard can be easily obtained with commercially available test inks from e.g. B. the company Arcotec Oberflächentechnik GmbH can be determined.

A possible arrangement of the separating element is shown in Figure 1. The separating element (6) is fitted into a hollow pin (5) in such a way that the liquid does not pass from the interior of the vessel to the desiccant. In a preferred embodiment, this is achieved by the separating element (6) resting on the opening of the hollow pin (5) facing the interior of the vessel. A flange (7) is mechanically connected to the hollow pin and is used to fasten the separating element (6) on the hollow pin (5). The flanging (7) closes off the space formed from drying agent chamber (4) and separating element (6) against liquids. Any minor leaks are sealed by swelling the separating element in contact with water and filling the gaps. Example 1 demonstrates the separating effect of the cardboard used against an aqueous reagent liquid even in the case of direct contact.

FIG. 2 shows vessels according to the invention arranged in a circle with desiccant plugs and in the middle two desiccant plugs with a volume of 2 or 4 ml for desiccant. Not only the shapes, but also the wall thicknesses of the vessels can vary within wide limits. The materials of the vessels must be impermeable to water, but can be partially permeable to water vapor. For the container, for example, plastics are suitable, such as those used for the production of bottles for storing liquids. However, wall thicknesses greater than 0.5 mm are preferred for reasons of mechanical stability and water vapor permeability. The way of making the vessels, e.g. B. injection molding or blow molding is not subject to any restriction, provided that a sufficient wall thickness can be guaranteed.

FIG. 3 shows the production of a liquid from a solid and a liquid. In illustration A, the solid is in the container closed by the desiccant plug. After opening the vessel (removal of the desiccant plug), illustration B shows the addition of liquid to the solid. After sealing the vessel with the aforementioned or a new closure, the solid is mixed with the liquid phase in FIG. 3C by shaking.

Reference list

(1):

Desiccant plug

(2):

Wall of the desiccant plug

(3):

Thread of the desiccant plug

(4):

Desiccant chamber

(5):

Hollow pin of the desiccant plug

(6):

Separating element

(7):

Flanging

Examples: example 1

Preparation of liquid reagents by dissolving solid reagents with water.

Barrier effect of a separating element in the form of cardboard and chemical indifference of the drying chamber.

Preparation of the liquid reagent

Systems for the preparation of liquids from solid reaction mixtures for the clinical-chemical determination of aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) by reaction with nicotinamide adenine dinucleotide (NADH) were tested.

To prepare ready-to-use reagents, solids were dissolved by filling the vessels with water and, after screwing on with the desiccant screw cap and shaking, were finally dissolved in the pre-calculated amount of water. The resulting reagent solution for determining GOT then had the following composition: Tris 27.8 mmol / l Tris HCL 58.4 mmol / l L-aspartate 254 mmol / l -Ketoglutarate 12.7 mmol / l NADH 0.19 mmol / l 2-chloroacetamide 10.7 mmol / l MDH 1200 U / l LDH 4390 U / l Polyvinyl pyrolidone approx. 0.1% by weight

The reagent solution for the determination of GPT had the following composition: Tris 15.9 mmol / l Tris · HCL 89.6 mmol / l L-alanine 530 mmol / l -Ketoglutarate 15.9 mmol / l NADH 0.19 mmol / l 2-chloroacetamide 10.7 mmol / l LDH 8900 U / l Polyvinyl pyrolidone approx. 0.1% by weight

Checking the blocking effect

The vessels were stored on the head for up to 24 hours, which is much more than the stress during normal use.

To check the barrier effect for liquids, the screw caps were then unscrewed and the cardboard separating elements (cardboard UD2 from Laakmann GmbH) removed for inspection of the desiccant. In all cases the desiccant was still dry, i.e. H. the blocking effect was given in all cases.

Check the chemical indifference of the desiccant chamber

• 1. Funktionskontrolle durch Bestimmung der Wiederfindung eines definierten GOT bzw. GPT-Gehaltes in einer Kontrollprobe (w [%]) bezogen auf den Referenzwert, der zu 100 % gesetzt wurde.
• 2. Wirkstoffgehalt (NADH-Gehalt) photometrisch bestimmt durch Extinktion bei 340 nm.

The chemical function was assessed on two test criteria:

• 1. Functional check by determining the recovery of a defined GOT or GPT content in a control sample (w [%]) based on the reference value, which was set to 100%.
• 2. Active substance content (NADH content) determined photometrically by absorbance at 340 nm.

The following reaction sequences take place at 1.

GOT:

GPT:

In der folgenden Tabelle sind die Versuchsergebnisse dargestellt:   Referenz 8 h/Kopf 16 h/Kopf 24 h/Kopf schwenken GOT-Reagenz w [%] 100.00 99.87 99.87 99.41 99.74 NADH-Extinktion 1.370 1.392 1.397 1.430 1.373 GPT-Reagenz w [%] 100.00 99.92 99.44 99.12 99.76 NADH-Extinktion 1.392 1.400 1.412 1.406 1.390

The test results are shown in the following table: reference 8 h / head 16 h / head 24 h / head swing GOT reagent w [%] 100.00 99.87 99.87 99.41 99.74 NADH absorbance 1,370 1,392 1,397 1,430 1,373 GPT reagent w [%] 100.00 99.92 99.44 99.12 99.76 NADH absorbance 1,392 1,400 1,412 1,406 1,390

The measured values show that the functionality of the reagent and the active substance content are only insignificantly influenced by the presence of the desiccant plug, even under extreme loads.

Example 2 Keep dry during storage.

Two batches of solid reagent mixtures for the clinical-chemical determination of aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) are tested.

The solid, which can be used for the preparation of reagent liquid for the determination of GPT, contained in 100 g of granules: Tris 2.72 g Tris · HCL 20.06 g L-alanine 67.07 g -Ketoglutarate 5.09 g NADH 1.34 g 2-chloroacetamide 1.42 g LDH approx. 0.34 g Polyvinyl pyrolidone approx.1.93 g

5.7 g of this mixture was stored in a system made of polyethylene with a wall thickness of approximately 1 mm, 1.4 g of drying agent (TM) in the form of a molecular sieve (type 511 from Grace GmbH) being used.

An analogous mixture for the determination of GOT contained per 100 g of granules: Tris 5.31 g Tris · HCL 14.48 g L-aspartate Na salt 70.31 g -Ketoglutarate 4.51 g NADH 1.48 g 2-chloroacetamide 1.57 g MDH approx. 0.22 g LDH about 0.19 g Polyvinyl pyrolidone approx. 1.97 g

In this experiment, 7.0 g of the mixture was stored using 1.4 g of the above molecular sieve as a drying agent.

To demonstrate the functionality of the system, a system with a desiccant screw cap was compared with other equivalent containers without a desiccant screw cap.

Test criteria were

• 1. water content in the filling material; determined with the Karl Fischer method.
• 2. Active substance content (NADH content); determined photometrically by absorbance at 340 nm.

Stress time Water content% by weight Absorbance 340 nm with TM without TM with TM without TM GOT 0 weeks 8.18% 8.18% 1,513 1,513 3 weeks 7.69% 8.46% 1,564 1,069 6 weeks 7.80% 9.20% 1,493 0.705 GPT 0 weeks 0.79% 0.79% 1.506 1.506 3 weeks 0.67% 1.04% 1,542 1,321 6 weeks 0.89% 1.23% 1,486 0.781

The example "GOT" additionally shows that only the stability-critical mobile moisture is selectively removed and the stability-uncritical immobile crystal water content remains unaffected.

Example 3

Drying back of a water-containing granulate due to production.

5.7 g of granules with an initial water content of 0.59% by weight (determined using the Karl Fischer method) were filled into a system for producing liquids and this was closed with the associated desiccant screw cap. The composition of the granules corresponded to the mixture mentioned in Example 2 for the determination of GPT. The Duplex 1 UD2 cardboard from Laakmann was used as the separating element. 1.4 g of molecular sieve were used as drying agents.

The system was kept in a room climate during the redrying phase and the water content was determined periodically using the Karl Fischer method.

FIG. 4 shows the dependence of the water content (f) as a function of the storage time (t) in days in the system.

□ :

22 ml Gefäßvolumen; 2 ml Trockenmittel

◇ :

50 ml Gefäßvolumen; 2 ml Trockenmittel

△ :

110 ml Gefäßvolumen; 2 ml Trockenmittel

X :

110 ml Gefäßvolumen; 4 ml Trockenmittel

Nach einem Tag war in allen Flaschen das Granulat auf einen Wassergehalt kleiner als 0,2 Gewichts-% zurückgetrocknet.Various combinations of vessel sizes are shown in the figure:

□:

22 ml tube volume; 2 ml desiccant

◇:

50 ml tube volume; 2 ml desiccant

△:

110 ml tube volume; 2 ml desiccant

X:

110 ml tube volume; 4 ml desiccant

After one day, the granules in all of the bottles had dried back to a water content of less than 0.2% by weight.

Claims (15)

System for preparing a liquid from at least one solid and at least one liquid phase, characterized by the combination of the following elements: - A vessel which contains the at least one solid and has a volume which is sufficient to hold the at least one solid and the at least one liquid phase; - A desiccant chamber containing a desiccant; - A water vapor permeable separating element that closes the desiccant chamber, so that the desiccant can exchange water vapor with the contents of the vessel at any time and the direct contact of a liquid or solid content of the vessel with the desiccant is essentially impossible. System according to Claim 1, characterized in that the chamber containing the desiccant serves to close the vessel. System according to one of the preceding claims, characterized in that the vessel consists of a material which is at least partially permeable to water vapor. System according to claim 3, characterized in that cardboard is used as the material for the separating element. System according to one of claims 1 to 4, characterized in that the separating element used is a material which has a surface tension critical for wetting, which is less than 70 mN / m, preferably 25 to 65 mN / m and particularly preferably 30 to 40 mN / m is. Use of a preparation system according to one of claims 1-5 for the preparation of reagent solutions. A method for producing a liquid using a preparation system according to any one of claims 1 to 5, comprising the following steps: a) Storage of the solid in a closed vessel b) opening the vessel c) adding liquid phase to the solid in the vessel d) closing the vessel e) Mixing solid and liquid phase so that a solution, suspension or emulsion is formed. A method according to claim 7, characterized in that the chamber containing the desiccant is used both before and after the addition of the liquid to close the vessel. Method according to one of claims 7 and 8, characterized in that the vessel is filled with the solid in an atmosphere containing water vapor. Method according to one of claims 7 to 9, characterized in that the vessel is automatically filled with the liquid phase by a device. Method according to one of claims 7 to 10, characterized in that a removal of prepared liquid from the vessel is carried out automatically by a device. Method according to one of claims 7 to 11, characterized in that both the preparation of the liquid and its use is carried out by a device. A method according to claim 7, wherein the storage of the solid component in the closed vessel serves to dry and / or keep it dry. A method according to claim 7, wherein the opening of the vessel in step b) is carried out by piercing with a cannula. A method for producing a liquid using a preparation system according to any one of claims 1 to 5, comprising the following steps: a) Storage of the solid in a closed vessel b) opening the vessel c) adding liquid phase to the solid in the vessel d) Mixing the solid and the liquid phase with the vessel open so that a solution, suspension or emulsion is formed.

Images