EP0585399A4 - Treatment of colorectal carcinoma with antisense oligonucleotides to c-myb proto-oncogene - Google Patents
Treatment of colorectal carcinoma with antisense oligonucleotides to c-myb proto-oncogeneInfo
- Publication number
- EP0585399A4 EP0585399A4 EP92913962A EP92913962A EP0585399A4 EP 0585399 A4 EP0585399 A4 EP 0585399A4 EP 92913962 A EP92913962 A EP 92913962A EP 92913962 A EP92913962 A EP 92913962A EP 0585399 A4 EP0585399 A4 EP 0585399A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- oncogene
- treatment
- antisense oligonucleotides
- colorectal carcinoma
- myb proto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70486291A | 1991-05-23 | 1991-05-23 | |
US704862 | 1991-05-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0585399A1 EP0585399A1 (en) | 1994-03-09 |
EP0585399A4 true EP0585399A4 (en) | 1995-11-15 |
Family
ID=24831149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92913962A Withdrawn EP0585399A4 (en) | 1991-05-23 | 1992-05-22 | Treatment of colorectal carcinoma with antisense oligonucleotides to c-myb proto-oncogene |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0585399A4 (en) |
JP (1) | JPH06508130A (en) |
CA (1) | CA2109829A1 (en) |
WO (1) | WO1992020348A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5646042A (en) * | 1992-08-26 | 1997-07-08 | Ribozyme Pharmaceuticals, Inc. | C-myb targeted ribozymes |
US5658780A (en) | 1992-12-07 | 1997-08-19 | Ribozyme Pharmaceuticals, Inc. | Rel a targeted ribozymes |
CA2151585A1 (en) * | 1992-12-14 | 1994-06-23 | Benjamin Weiss | Administration of oligonucleotides antisense to dopamine receptor mrna for diagnosis and treatment of neurological pathologies |
DE4338704A1 (en) * | 1993-11-12 | 1995-05-18 | Hoechst Ag | Stabilized oligonucleotides and their use |
DE19502912A1 (en) * | 1995-01-31 | 1996-08-01 | Hoechst Ag | G-Cap Stabilized Oligonucleotides |
US5994320A (en) * | 1995-02-06 | 1999-11-30 | Regents Of The University Of Minnesota | Antisense oligonucleotides and methods for treating central nervous system tumors |
GB9504598D0 (en) | 1995-03-03 | 1995-04-26 | Imp Cancer Res Tech | Method of nucleic acid analysis |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990005445A1 (en) * | 1988-11-07 | 1990-05-31 | Temple University Of The Commonwealth System Of Higher Education | Antisense oligonucleotides to c-myb proto-oncogene and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4740463A (en) * | 1984-04-13 | 1988-04-26 | Massachusetts Institute Of Technology | Methods and artificial genes for antagonizing the function of an oncogene |
-
1992
- 1992-05-22 CA CA002109829A patent/CA2109829A1/en not_active Abandoned
- 1992-05-22 WO PCT/US1992/004318 patent/WO1992020348A1/en not_active Application Discontinuation
- 1992-05-22 JP JP5500313A patent/JPH06508130A/en active Pending
- 1992-05-22 EP EP92913962A patent/EP0585399A4/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990005445A1 (en) * | 1988-11-07 | 1990-05-31 | Temple University Of The Commonwealth System Of Higher Education | Antisense oligonucleotides to c-myb proto-oncogene and uses thereof |
US5098890A (en) * | 1988-11-07 | 1992-03-24 | Temple University-Of The Commonwealth System Of Higher Education | Antisence oligonucleotides to c-myb proto-oncogene and uses thereof |
Non-Patent Citations (3)
Title |
---|
MELANI, C. ET AL.: "C-MYB EXPRESSION IN HUMAN COLON CARCINOMA CELL LINES AND EFFECT OF C- MYB ANTISENSE OLIGONUCLEOTIDE ON CELL PROLIFERATION.", PROC AM ASSOC CANCER RES ANNU MEET 32 (0), 428;, March 1991 (1991-03-01) * |
MELANI, C. ET AL.: "INHIBITION OF PROLIFERATION BY C- MYB ANTISENSE OLIGODEOXYNUCLEOTIDES IN COLON ADENOCARCINOMA CELL LINES THAT EXPRESS C-MYB.", CANCER RES 51 (11), 2897-2901., 1 June 1991 (1991-06-01) * |
See also references of WO9220348A1 * |
Also Published As
Publication number | Publication date |
---|---|
JPH06508130A (en) | 1994-09-14 |
CA2109829A1 (en) | 1992-11-26 |
EP0585399A1 (en) | 1994-03-09 |
WO1992020348A1 (en) | 1992-11-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19931028 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19950929 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 19960802 |