EP0192794A1 - Liquid preserving vessel for use in liquid sample analyzers - Google Patents
Liquid preserving vessel for use in liquid sample analyzers Download PDFInfo
- Publication number
- EP0192794A1 EP0192794A1 EP85102198A EP85102198A EP0192794A1 EP 0192794 A1 EP0192794 A1 EP 0192794A1 EP 85102198 A EP85102198 A EP 85102198A EP 85102198 A EP85102198 A EP 85102198A EP 0192794 A1 EP0192794 A1 EP 0192794A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- vessel
- liquid
- layer
- air
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
Definitions
- the present invention relates to a vessel for preserving liquids used for keeping standard solutions hermetically sealed against environmental influences and used for calibrating a calcium electrode and a pH electrode of liquid sample analyzers such as a blood analyzer.
- a mouth portion thereof is directly connected with an analyzer b so as to feed said analyzer b with the appointed quantity of a calibrating solution contained therein at a time when said analyzer b is calibrated.
- the conventional vessels for preserving liquids have the disadvantage that they are generally inflexible polyethylene tanks or glass bottles, and therefore, an internal air layer is expanded with the consumption of the liquid, whereby the chemical composition of the calibrating solution is changed due to the absorption of C0 2 contained in the air and also the concentration varies due to evaporation.
- a vessel for preserving of the liquid used in liquid sample analyzers comprises the technical features as defined in claim 1.
- Advantageous embodiments of the invention are the subject of dependent claims.
- a vessel for preserving liquids is formed of a hermectically closed bag member 4 consisting of two pieces of membrane member 2, (2) provided with a mouth member 1 made of hard plastic materials, which is sealed up tightly with a rubber plug 3, fixedly adhered to the lower end portion thereof and connected with each other all over the circumference thereof.
- 5 designates a hanging hole provided in the upper joined portion of said two pieces of membrane members 2, (2).
- a four-layer laminated membrane consisting of the outermost polyester layer a, a vacuum deposited aluminium layer b, a nylon layer c (15 microns) and a low-density polyethylene layer d (100 microns), the thickness of said layer a and said layer b reaching 12 microns in all, as shown in Fig. 4, is used as said membrane member 2.
- Said membrane member 2 is made of materials having high flexibility and having superior sealing and cut off properties for air, water vapour and light at the same time.
- a cap 6 which is provided with a small hole 6a for letting pass a syringe therethrough at the center thereof, can be screwed in said mouth member 1.
- the solution which contains TRIS, that is to say tris(hydroxymethyl)aminomethane, as a buffering agent, is enclosed in a vessel for preserving liquids as a standard calibrating solution for calibrating of analyzers, in which for example calcium ions and pH are determined at the same time, so that said solution may be filled in said vessel in such a manner that residual air is not contained in said solution at all.
- the calibrating solution which hardly shows an affinity to calcium ions, can be prepared by using TRIS as a buffering agent instead of those cases where BES and TES are used as buffering agents.
- Said vessel in which the calibrating solution is enclosed in the above described manner, is connected with an analyzer 7 to calibrate said analyzer 7, as shown in Fig. 5.
- 8 designate pipes for introducing a liquid to be tested, 9 designating a pipe for introducing the calibrating solution, 10 designating a switch valve, 11 designating a drawing pump, 12 designating a flow-through type ion electrode as a measuring member, and 13 designating a drain pipe.
- Said vessel for preserving liquids is fixed by inserting said hanging hole 5 over a hook 14 or the like and is connected with said pipe 9 for introducing the calibrating solution of said analyzer 7 by inserting a syringe 16 provided with a connecting tube 15 into said rubber plug 3 of said mouth member 1.
- a vessel for preserving liquids for use in analyzers for liquid samples is characterized in that it is formed of a closed bag member 4 consisting of membrane members 2 (2),of which a mouth portion 1 is tightly sealed with a rubber plug 3, having remarkably small permeability to air and water vapour and great flexibility.
- the bag member 4 made of greatly flexible materials contracts with the reduction of the quantity of liquid contained in said vessel even though liquid contained in the vessel is consumed, the pressure inside the vessel is not reduced so much.
- the bag member 4 is made of materials having remarkably small permeability to air and water vapour, the intrusion of air from the outside as well as the evaporation and penetration of water vapour can be satisfactorily prevented, and therefore, the composition and concentration of the liquid contained in the vessel can be held constant for a long time. Therefore, a vessel according to the present invention can be very effectively used for a highly accurate determination of liquid quantities, for calibration purposes and the like.
Abstract
Description
- The present invention relates to a vessel for preserving liquids used for keeping standard solutions hermetically sealed against environmental influences and used for calibrating a calcium electrode and a pH electrode of liquid sample analyzers such as a blood analyzer.
- In a vessel for preserving liquids of this type as marked with a in Fig. 1, a mouth portion thereof is directly connected with an analyzer b so as to feed said analyzer b with the appointed quantity of a calibrating solution contained therein at a time when said analyzer b is calibrated. However, the conventional vessels for preserving liquids have the disadvantage that they are generally inflexible polyethylene tanks or glass bottles, and therefore, an internal air layer is expanded with the consumption of the liquid, whereby the chemical composition of the calibrating solution is changed due to the absorption of C02 contained in the air and also the concentration varies due to evaporation.
- That is to say, in general, the calibrating solutions containing buffering agents such as BES (N,N-bis(2-hydroxymethyl)-2-aminoethane sulfonic acid) (pK = 6.9 at 37°C) and TES (N-tris(hydroxymethyl)methyl-2-aminoethane sulfonic acid) (pK = 7.22 at 37°C) having a pK value near the desired calibrating pH are used in such analyzers for determining calcium ions and pH at the same time, but, these buffering agents show a great affinity to calcium ions, whereby the difference is apt to be produced between the concentration of calcium weighted when the calibrating solution is prepared and the concentration of calcium ions in the prepared calibrating solution so that its preparation is difficult. In addition, in cases where such calibrating solutions are put in the above described conventional polyethylene tanks and glass bottles, as above described, an air layer is expanding with the consumption of calibrating solution and the calcium ions are bonded to C02 contained in the air to form a sediment of calcium carbonate or evaporation takes place, and as a result, the calibrating solution is changed in composition and concentration, such that the correct calibration can not be achieved.
- Thus, it is an object of the present invention to provide a vessel for preserving liquids for use in an analyzer of liquid samples which can control the intrusion of air thereinto from the outside as far as possible when the volume of the internal liquid is reduced (that is to say, the calibrating solution contained in the vessel is consumed) and further can prevent water vapour from evaporating and intruding.
- A vessel for preserving of the liquid used in liquid sample analyzers according to the invention comprises the technical features as defined in
claim 1. Advantageous embodiments of the invention are the subject of dependent claims. - An example of the invention is described in the following with reference to the drawings wherein
- Fig. 1 is a sketch for illustrating the problems of the prior art;
- Figs. 2 to 5 illustrate the preferred embodiments of a vessel for preserving liquids for use in analyzers for liquid samples according to the present invention, in which
- Fig. 2 is a partially sectioned front view showing a vessel according to the present invention; Fig. 3 is a sectional view taken along the line III-III of Fig. 2;
- Fig. 4 is an enlarged sectional view showing the principal members of a vessel according to the present invention; and
- Fig. 5 is a diagram illustrating an example of the application of a vessel according to the present invention in which a part (vessel) is solidly illustrated.
- The preferred ambodiments of a vessel according to the present invention will be described below with reference to Figs. 2 to 5.
- As shown in Figs. 2, 3 a vessel for preserving liquids is formed of a hermectically closed bag member 4 consisting of two pieces of
membrane member 2, (2) provided with amouth member 1 made of hard plastic materials, which is sealed up tightly with arubber plug 3, fixedly adhered to the lower end portion thereof and connected with each other all over the circumference thereof. 5 designates a hanging hole provided in the upper joined portion of said two pieces ofmembrane members 2, (2). - A four-layer laminated membrane consisting of the outermost polyester layer a, a vacuum deposited aluminium layer b, a nylon layer c (15 microns) and a low-density polyethylene layer d (100 microns), the thickness of said layer a and said layer b reaching 12 microns in all, as shown in Fig. 4, is used as said
membrane member 2. Saidmembrane member 2 is made of materials having high flexibility and having superior sealing and cut off properties for air, water vapour and light at the same time. - In addition, a
cap 6, which is provided with asmall hole 6a for letting pass a syringe therethrough at the center thereof, can be screwed in saidmouth member 1. - The solution, which contains TRIS, that is to say tris(hydroxymethyl)aminomethane, as a buffering agent, is enclosed in a vessel for preserving liquids as a standard calibrating solution for calibrating of analyzers, in which for example calcium ions and pH are determined at the same time, so that said solution may be filled in said vessel in such a manner that residual air is not contained in said solution at all. The calibrating solution, which hardly shows an affinity to calcium ions, can be prepared by using TRIS as a buffering agent instead of those cases where BES and TES are used as buffering agents.
- Said vessel, in which the calibrating solution is enclosed in the above described manner, is connected with an
analyzer 7 to calibrate saidanalyzer 7, as shown in Fig. 5. Referring to Fig. 5, 8 (8) designate pipes for introducing a liquid to be tested, 9 designating a pipe for introducing the calibrating solution, 10 designating a switch valve, 11 designating a drawing pump, 12 designating a flow-through type ion electrode as a measuring member, and 13 designating a drain pipe. Said vessel for preserving liquids is fixed by inserting said hanginghole 5 over ahook 14 or the like and is connected with saidpipe 9 for introducing the calibrating solution of saidanalyzer 7 by inserting asyringe 16 provided with aconnecting tube 15 into saidrubber plug 3 of saidmouth member 1. If saidswitch valve 10 is switched over to the calibration side under such a condition, the calibrating solution is transferred to saidion electrode 12 in a determined quantity at every time by means of saiddrawing pump 11 to carry out the calibration. Then, said membrane members are gradually contracted with a gradual reduction of the volume of the calibrating solution contained in said vessel due to the high flexibility of the membrane material, whereby air cannot penetrate into said vessel from the outside. - Furthermore, since there is no solution passing through a
passage 17 between saiddrawing pump 11 and saidion electrode 12 if the calibrating solution is completely consumed, asensor 18 for detecting the complete consumption of said calibrating solution is provided and the exchange-alarm for the calibrating solution is given on the basis of the detection result to stop saiddrawing pump 11 automatically. Thus, the provision of an apparatus and a scale for detecting the liquid level at the vessel side is not required, and such a disadvantage adhereing to the prior art that thepump 11 is operated under the condition that no liquid is flowing and air is transferred to saidion electrode 12 and it must be dried can effectively be prevented. - In short, a vessel for preserving liquids for use in analyzers for liquid samples according to the present invention is characterized in that it is formed of a closed bag member 4 consisting of membrane members 2 (2),of which a
mouth portion 1 is tightly sealed with arubber plug 3, having remarkably small permeability to air and water vapour and great flexibility. - Further, since the bag member 4 made of greatly flexible materials contracts with the reduction of the quantity of liquid contained in said vessel even though liquid contained in the vessel is consumed, the pressure inside the vessel is not reduced so much. In addition, since the bag member 4 is made of materials having remarkably small permeability to air and water vapour, the intrusion of air from the outside as well as the evaporation and penetration of water vapour can be satisfactorily prevented, and therefore, the composition and concentration of the liquid contained in the vessel can be held constant for a long time. Therefore, a vessel according to the present invention can be very effectively used for a highly accurate determination of liquid quantities, for calibration purposes and the like.
Claims (2)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19850102198 EP0192794B1 (en) | 1985-02-27 | 1985-02-27 | Liquid preserving vessel for use in liquid sample analyzers |
DE8585102198T DE3563421D1 (en) | 1985-02-27 | 1985-02-27 | Liquid preserving vessel for use in liquid sample analyzers |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19850102198 EP0192794B1 (en) | 1985-02-27 | 1985-02-27 | Liquid preserving vessel for use in liquid sample analyzers |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0192794A1 true EP0192794A1 (en) | 1986-09-03 |
EP0192794B1 EP0192794B1 (en) | 1988-06-22 |
Family
ID=8193327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19850102198 Expired EP0192794B1 (en) | 1985-02-27 | 1985-02-27 | Liquid preserving vessel for use in liquid sample analyzers |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0192794B1 (en) |
DE (1) | DE3563421D1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0697248A1 (en) * | 1994-08-18 | 1996-02-21 | ABX , Société Anonyme dite | Reagent distribution housing for automatic connection to an apparatus such as a blood analyser |
EP0724152A2 (en) * | 1995-01-25 | 1996-07-31 | Przedsiebiorstwo Zagraniczne Htl | Device, method and measuring electrode for determining the parameters of a liquid |
EP0967076A1 (en) * | 1998-06-26 | 1999-12-29 | Konica Corporation | Packaging materials for electrophotographic development materials, a packaging method, and toner and developer material for electrophotographic development |
WO2000053320A1 (en) * | 1999-03-09 | 2000-09-14 | Biomerieux S.A. | Pumping device for transferring at least a fluid into a consumable |
US7169353B1 (en) | 1999-03-09 | 2007-01-30 | Biomerieux S.A. | Apparatus enabling liquid transfer by capillary action therein |
US9889447B2 (en) | 2013-07-26 | 2018-02-13 | Sekisui Medical Co. , Ltd. | Reagent supplying device |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3368560A (en) * | 1965-10-07 | 1968-02-13 | Theodore H. Gewecke | Outlet fitting for plastic parenteral solution container |
US4116336A (en) * | 1975-05-30 | 1978-09-26 | Radiometer A/S | Package containing a reference liquid for blood gas equipment |
DE2719113A1 (en) * | 1977-04-29 | 1978-11-09 | Sengewald Kg Karl H | Polymer film laminate for packaging - comprises a gas, vapour and odour impermeable polymer support laminated with a metal coating or a metal pigmented polymer film |
DE2926439A1 (en) * | 1978-06-29 | 1980-01-10 | Mitsui Petrochemical Ind | MULTI-LAYER BAG STRUCTURE FOR PACKAGING |
EP0069642A1 (en) * | 1981-07-06 | 1983-01-12 | Rhone-Poulenc Films | Process for the packaging of oxygen and/or water vapour sensitive materials |
US4387126A (en) * | 1982-02-10 | 1983-06-07 | Champion International Corporation | Laminated packaging material |
FR2521956A1 (en) * | 1982-02-25 | 1983-08-26 | Fluilogic Systems Oy | METHOD FOR STORING AND IMPLEMENTING AN ANALYSIS REAGENT OR OTHER SUBSTANCE FOR ANALYZES, AND REAGENT PACKAGING FOR THE APPLICATION OF THE PROCESS |
-
1985
- 1985-02-27 EP EP19850102198 patent/EP0192794B1/en not_active Expired
- 1985-02-27 DE DE8585102198T patent/DE3563421D1/en not_active Expired
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3368560A (en) * | 1965-10-07 | 1968-02-13 | Theodore H. Gewecke | Outlet fitting for plastic parenteral solution container |
US4116336A (en) * | 1975-05-30 | 1978-09-26 | Radiometer A/S | Package containing a reference liquid for blood gas equipment |
DE2719113A1 (en) * | 1977-04-29 | 1978-11-09 | Sengewald Kg Karl H | Polymer film laminate for packaging - comprises a gas, vapour and odour impermeable polymer support laminated with a metal coating or a metal pigmented polymer film |
DE2926439A1 (en) * | 1978-06-29 | 1980-01-10 | Mitsui Petrochemical Ind | MULTI-LAYER BAG STRUCTURE FOR PACKAGING |
EP0069642A1 (en) * | 1981-07-06 | 1983-01-12 | Rhone-Poulenc Films | Process for the packaging of oxygen and/or water vapour sensitive materials |
US4387126A (en) * | 1982-02-10 | 1983-06-07 | Champion International Corporation | Laminated packaging material |
FR2521956A1 (en) * | 1982-02-25 | 1983-08-26 | Fluilogic Systems Oy | METHOD FOR STORING AND IMPLEMENTING AN ANALYSIS REAGENT OR OTHER SUBSTANCE FOR ANALYZES, AND REAGENT PACKAGING FOR THE APPLICATION OF THE PROCESS |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0697248A1 (en) * | 1994-08-18 | 1996-02-21 | ABX , Société Anonyme dite | Reagent distribution housing for automatic connection to an apparatus such as a blood analyser |
FR2723735A1 (en) * | 1994-08-18 | 1996-02-23 | Abx Sa | AUTOMATIC CONNECTION HOUSING FOR DISPENSING REAGENTS IN AN APPARATUS, IN PARTICULAR A HEMATOLOGICAL ANALYZER. |
US5665315A (en) * | 1994-08-18 | 1997-09-09 | Abx Sa | Automatic connection box for distributing reagents in a haematological analyzer |
EP0724152A2 (en) * | 1995-01-25 | 1996-07-31 | Przedsiebiorstwo Zagraniczne Htl | Device, method and measuring electrode for determining the parameters of a liquid |
EP0724152A3 (en) * | 1995-01-25 | 1998-09-23 | Przedsiebiorstwo Zagraniczne Htl | Device, method and measuring electrode for determining the parameters of a liquid |
EP0967076A1 (en) * | 1998-06-26 | 1999-12-29 | Konica Corporation | Packaging materials for electrophotographic development materials, a packaging method, and toner and developer material for electrophotographic development |
US6355355B1 (en) | 1998-06-26 | 2002-03-12 | Konica Corporation | Packaging materials for electrophotographic development materials, a packaging method, and toner and developer material for electrophotographic development |
WO2000053320A1 (en) * | 1999-03-09 | 2000-09-14 | Biomerieux S.A. | Pumping device for transferring at least a fluid into a consumable |
US7169353B1 (en) | 1999-03-09 | 2007-01-30 | Biomerieux S.A. | Apparatus enabling liquid transfer by capillary action therein |
US9889447B2 (en) | 2013-07-26 | 2018-02-13 | Sekisui Medical Co. , Ltd. | Reagent supplying device |
Also Published As
Publication number | Publication date |
---|---|
EP0192794B1 (en) | 1988-06-22 |
DE3563421D1 (en) | 1988-07-28 |
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