EP0021405A1 - Drip chamber provided with a spike having an improved fitting ability - Google Patents

Drip chamber provided with a spike having an improved fitting ability Download PDF

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Publication number
EP0021405A1
EP0021405A1 EP80103563A EP80103563A EP0021405A1 EP 0021405 A1 EP0021405 A1 EP 0021405A1 EP 80103563 A EP80103563 A EP 80103563A EP 80103563 A EP80103563 A EP 80103563A EP 0021405 A1 EP0021405 A1 EP 0021405A1
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EP
European Patent Office
Prior art keywords
drip chamber
profiles
chamber according
spike
mandrel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP80103563A
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German (de)
French (fr)
Inventor
Bernd Dr. Braun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intermedicat GmbH
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Intermedicat GmbH
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Filing date
Publication date
Application filed by Intermedicat GmbH filed Critical Intermedicat GmbH
Publication of EP0021405A1 publication Critical patent/EP0021405A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A61M2005/1623—Details of air intake

Definitions

  • Infusion and transfusion devices which serve to transfer parenteral solutions or blood from glass or plastic containers into the blood vessels of the human body, are provided with a plastic drip chamber for the purpose of dosing.
  • the drip chamber consists of a conical mandrel with an opening and the actual drip chamber with the outflow tube.
  • the drip chamber is inserted through the container closure by means of its pointed mandrel and must have a tight fit in the closure so that the mandrel does not slide out of the closure under tensile stress.
  • Closures and adhesive strength of the mandrel are standardized in DIN 58 363.
  • infusion solutions are also largely supplied in plastic containers that are not sealed with standardized rubber stoppers, but only with a few millimeter-thick elastic washer, which increases the risk that the mandrel will slide out of the container even with low tensile stress and that Infusion is contaminated.
  • the surface of the mandrel is more or less smooth depending on the type of plastic used (polystyrene, polyamide or another plastic). This has the disadvantage that the spike cannot have a sufficiently firm fit, which is particularly the case with thin-walled closures or plugs.
  • the object of the invention is therefore to ensure that the piercing mandrel and thus the infusion line are firmly seated in a thin-walled sealing disc or a stopper.
  • the invention relates to a drip chamber for a Infusion or transfusion device which has a piercing spike for piercing the rubber-like, elastic sealing plug or the sealing disk of the infusion container, which is provided with an inflow hole in the region of its tapering end, characterized in that on the outer surface of the piercing mandrel on an at the inflow hole subsequent section in the axial direction parallel successive circumferential profiles are formed.
  • the profiling provided according to the invention on the outer surface of the piercing mandrel ensures that the piercing mandrel is firmly seated in the sealing disk or the sealing plug of an infusion container which e.g. can be made of glass or plastic.
  • the profiles can surround the piercing mandrel in a ring.
  • the profiles can surround the piercing mandrel in a semicircle.
  • the profiles can be formed by brushed, fine parallel ribs or by engraved parallel ribs or by molded-in sharp-edged ribs.
  • the ribs can be sawtooth-shaped in cross section.
  • Fig. 1 shows a drip chamber
  • the drip chamber shown in Fig. 1 consists of a conical spike 1 with solution inflow hole and the actual drip chamber 2 with the outflow tube.
  • the piercing mandrel 1 is inserted through the container closure and must have a tight fit in position 3.
  • FIG. 2 shows the piercing mandrel 21 which is connected to the drip chamber 22 and which, according to the invention, has circumferential profiles 23 which follow one another in parallel in the axial direction.
  • FIG. 3 shows a piercing mandrel 31, the drip chamber 32 and the profiles 33.
  • the profiles according to the exemplary embodiment of FIG. 2 are produced chemically and mechanically by dissolving the surface of the mandrel part which is to carry the profiles 23 in rotating contact with a brush or brush device brushed in an organic solvent, preferably acetone, and by rotating hard bristles provided with fine, parallel grooves that form the profiles 23.
  • the profiles 33 according to FIG. 3 can be produced technically and mechanically by using a heated combination pliers in one or both jaws parallel grooves of approx. 1 mm depth are engraved at 7o - 80 ° C on the part of the piercing mandrel that is to carry the profiles. A pull-out force of 60 N is achieved in this way.
  • the profiles 43 according to FIG. 4 can be produced by injection molding. Because of specific requirements when demoulding injection molded parts, sawtooth-like designs are generally only semicircularly attached to the piercing mandrel part, which should have the profiles 43.
  • This arrangement has the advantage that the pull-out elements, i.e. the profiles 43 are molded in a cost-effective process already during the manufacture of the injection molded part and a second processing step is omitted.
  • the tooth-like ribs are designed with sharp edges.

Abstract

The invention relates to a drip chamber for an infusion and transfusion system, which chamber exhibits a penetration spike for penetration into the rubber-like, elastic closure plug or the closure disc of the infusion container, which in the region of its sharply tapering end is provided with an inflow aperture, and profilings extending in succession according to the periphery parallel in the axial direction are formed on a portion (3) adjoining the inflow aperture. <IMAGE>

Description

Infusions- und Transfusionsgeräte, die zur Überleitung von parenteralen Lösungen oder Blut aus Glas- oder Kunst stoffbehältern in die Blutgefäße des menschlichen Körpers dienen, sind zwecks Dosierungsmöglichkeit mit einer aus Kunststoff bestehenden Tropfkammer versehen. Die Tropfkammer besteht aus einem konisch verlaufenden Dorn mit Öffnung und der eigentlichen Tropfkammer mit dem Ausflußtubus.Infusion and transfusion devices, which serve to transfer parenteral solutions or blood from glass or plastic containers into the blood vessels of the human body, are provided with a plastic drip chamber for the purpose of dosing. The drip chamber consists of a conical mandrel with an opening and the actual drip chamber with the outflow tube.

Die Tropfkammer wird mittels ihres spitzen Dorns durch den Behälterverschluss hindurch eingesteckt und muss in dem Verschluss einen festen Sitz haben, damit der Dorn bei Zugbeanspruchung nicht aus dem Verschluss herausgleitet. Verschlüsse und Haftfestigkeit des Dorns sind in DIN 58 363 genormt. Infusionslösungen werden außer in Glasflaschen zum großen Teil auch in Kunststoffbehältern geliefert, die nicht mit genormten Kautschukstopfen, sondern nur mit einer einige Millimeter dicken elastischen Scheibe verschlossen sind, wodurch verstärkt die Gefahr besteht, daß der Dorn selbst bei geringer Zugbeanspruchung aus dem Behälter herausgleitet und die Infusions kontaminiert wird.The drip chamber is inserted through the container closure by means of its pointed mandrel and must have a tight fit in the closure so that the mandrel does not slide out of the closure under tensile stress. Closures and adhesive strength of the mandrel are standardized in DIN 58 363. In addition to glass bottles, infusion solutions are also largely supplied in plastic containers that are not sealed with standardized rubber stoppers, but only with a few millimeter-thick elastic washer, which increases the risk that the mandrel will slide out of the container even with low tensile stress and that Infusion is contaminated.

Die Dornoberfläche ist je nach dem verwendeten Kunststofftyp (Polystyrol, Polyamid oder ein anderer Kunststoff) mehr oder weniger glatt. Dies hat den Nachteil, daß der Einstechdorn keinen ausreichend festen Sitz haben kann, was insbesondere bei dünnwandigen Verschluss scheiben oder Stopfen der Fall ist.The surface of the mandrel is more or less smooth depending on the type of plastic used (polystyrene, polyamide or another plastic). This has the disadvantage that the spike cannot have a sufficiently firm fit, which is particularly the case with thin-walled closures or plugs.

Die Erfindung stellt sich daher die Aufgabe, einen festen Sitz des Einstechdorns und damit der Infusionsleitung in einer dünnwandigen Verschlußscheibe oder einem Stopfen zu sichern.The object of the invention is therefore to ensure that the piercing mandrel and thus the infusion line are firmly seated in a thin-walled sealing disc or a stopper.

Gegenstand der Erfindung ist eine Tropfkammer für ein Infusions- oder Transfusionsgerät, die einen Einstechdorn zum Einstechen in den gummiartigen, elastischen Verschlußstopfen oder die Verschlußscheibe des Infusionsbehälters aufweist, der im Bereich seines spitz zulaufenden Endes mit einem Einflußloch versehen ist, dadurch gekennzeichnet, daß auf der Außenfläche des Einstechdorns auf einem an das Einflußloch anschließenden Abschnitt in Achsrichtung parallel aufeinander folgende umfangsmässig verlaufende Profilierungen ausgebildet sind.The invention relates to a drip chamber for a Infusion or transfusion device which has a piercing spike for piercing the rubber-like, elastic sealing plug or the sealing disk of the infusion container, which is provided with an inflow hole in the region of its tapering end, characterized in that on the outer surface of the piercing mandrel on an at the inflow hole subsequent section in the axial direction parallel successive circumferential profiles are formed.

Durch die erfindungsgemäss vorgesehenen Profilierungen auf der Außenfläche des Einstechdorns wird ein fester Sitz des Einstechdorns in der Verschlußscheibe oder der Verschlußstopfen eines Infusionsbehälters, der z.B. aus Glas oder Kunststoff sein kann, gewährt.The profiling provided according to the invention on the outer surface of the piercing mandrel ensures that the piercing mandrel is firmly seated in the sealing disk or the sealing plug of an infusion container which e.g. can be made of glass or plastic.

Bei einer Ausführungsform der Erfindung können die Profilierungen den Einstechdorn ringförmig umgeben.In one embodiment of the invention, the profiles can surround the piercing mandrel in a ring.

Bei einer anderen Ausführungsform können die Profilierungen den Einstechdorn halbkreisförmig umgeben.In another embodiment, the profiles can surround the piercing mandrel in a semicircle.

Die Profilierungen können durch eingebürstete, feine parallele Rippen oder durch eingravierte parallele Rippen oder durch eingeformte scharfkantige Rippen gebildet sein. Die Rippen können im Querschnitt sägezahnförmig ausgestaltet sein.The profiles can be formed by brushed, fine parallel ribs or by engraved parallel ribs or by molded-in sharp-edged ribs. The ribs can be sawtooth-shaped in cross section.

Die Erfindung wird nachstehend anhand der Zeichnungen erläutert.The invention is explained below with reference to the drawings.

Fig. 1 zeigt eine Tropfkammer.Fig. 1 shows a drip chamber.

Fig. 2 - 5 zeigen jeweils einen an einer Tropfkammer befindlichenEinstechdorn sowie einen Querschnitt des Einstechdorns.2-5 each show a piercing mandrel located on a drip chamber and a cross section of the piercing mandrel.

Die in Fig. 1 dargestellte Tropfkammer besteht aus einem konisch verlaufenden Einstechdorn 1 mit Lösungseinflußloch und der eigentlichen Tropfkammer 2 mit dem Ausflußtubus. Der Einstechdorn 1 wird durch den Behälterverschluss hindurch eingesteckt und muss in der Position 3 einen festen Sitz haben.The drip chamber shown in Fig. 1 consists of a conical spike 1 with solution inflow hole and the actual drip chamber 2 with the outflow tube. The piercing mandrel 1 is inserted through the container closure and must have a tight fit in position 3.

Fig. 2 zeigt den Einstechdorn 21, der mit der Tropfkammer 22 verbunden ist und der erfindungsgemäss in Achsrichtung parallel aufeinander folgende umfangsmässig verlaufende Profilierungen 23 aufweist.FIG. 2 shows the piercing mandrel 21 which is connected to the drip chamber 22 and which, according to the invention, has circumferential profiles 23 which follow one another in parallel in the axial direction.

Fig. 3 zeigt einen Einstechdorn 31, die Tropfkammer 32 und die Profilierungen 33.3 shows a piercing mandrel 31, the drip chamber 32 and the profiles 33.

Fig. 4 zeigt den Einstechdorn 41, die Tropfkammer 42 sowie die Profilierungen 43.4 shows the piercing mandrel 41, the drip chamber 42 and the profiles 43.

Fig. 5 zeigt den Einstechdorn 51, die Tropfkammer 52 sowie die Profilierungen 53.5 shows the piercing mandrel 51, the drip chamber 52 and the profiles 53.

Die Profilierungen gemäss Ausführungsbeispiel von Fig. 2 werden chemisch-mechanisch hergestellt, indem man die Oberfläche des Dornteils, der die Profilierungen 23 tragen soll, in rotierendem Kontakt mit einer in ein organisches Lösungsmittel, vorzugsweise Aceton, gebürsteten Bürsten- oder Pinselvorrichtung anlöst und durch Dreheinwirkung harter Borsten mit feinen, parallel verlaufenden Rillen versieht, die die Profilierungen 23 bilden. Hierdurch erhöht sich die Sitzfestigkeit des Einstechdorns von ca 12 N auf 37 N, wobei 1 N = 1 kg m/Sek.2 entspricht.The profiles according to the exemplary embodiment of FIG. 2 are produced chemically and mechanically by dissolving the surface of the mandrel part which is to carry the profiles 23 in rotating contact with a brush or brush device brushed in an organic solvent, preferably acetone, and by rotating hard bristles provided with fine, parallel grooves that form the profiles 23. This increases the seating strength of the piercing mandrel from approx. 12 N to 37 N, where 1 N = 1 kg m / sec. 2 corresponds.

Die Profilierungen 33 gemäss Fig. 3 lassen sich technisch-mechanisch herstellen, indem man mit einer angewärmten Kombizange, in deren einer oder beiden Backen parallel verlaufende Rillen von ca 1 mm Tiefe eingraviert sind an dem Teil des Einstechdorns, der die Profilierungen tragen soll, bei 7o - 80°C entsprechende Rillen einpresst. Hierdurch wird eine Auszugskraft von 60 N erzielt.The profiles 33 according to FIG. 3 can be produced technically and mechanically by using a heated combination pliers in one or both jaws parallel grooves of approx. 1 mm depth are engraved at 7o - 80 ° C on the part of the piercing mandrel that is to carry the profiles. A pull-out force of 60 N is achieved in this way.

Die Profilierungen 43 gemäss Fig. 4 können durch Spritzeh erzeugt werden. Wegen spezifischer Anforderungen beim Entformen von Spritzgußteilen werden sägezahnartige Ausbildungen im allgemeinen nur halbkreisförmig an dem Ein stechdornteil angebracht, der die Profilierungen 43 aufweisen soll. Diese Anordnung hat den Vorteil, daß die dieAuszugskraft erhöhenden Elemente, d.h. die Profilierungen 43,in einem kostengünstigen Verfahren schon bei der Herstellung des Spritzgußteils mitgeformt werden und ein zweiter Bearbeitungsgang entfällt. Um einen möglichst hohen Auszugswiderstand zu einem elastischen Verschluss zu erhalten, sind die zahnartigen Rippen scharfkantig gestaltet.The profiles 43 according to FIG. 4 can be produced by injection molding. Because of specific requirements when demoulding injection molded parts, sawtooth-like designs are generally only semicircularly attached to the piercing mandrel part, which should have the profiles 43. This arrangement has the advantage that the pull-out elements, i.e. the profiles 43 are molded in a cost-effective process already during the manufacture of the injection molded part and a second processing step is omitted. In order to obtain the highest possible pull-out resistance for an elastic closure, the tooth-like ribs are designed with sharp edges.

Im Spritzverfahren erzielt man Auszugskraftwerte von 5o N bei halbkreisförmiger und von 80 N bei ringförmiger Profilierung.Extraction force values of 5o N with semicircular and 80 N with annular profiling are achieved in the spraying process.

Es ist jedoch auch möglich, die in Fig. 5 gezeigten scharfkantigen Profilierungen 53 unter Verwendung eines Doppelbacken-Formwerkzeugs herzustellen, so daß die scharfkantigen Absätze den ganzen Einstechdornteil auch ringförmig umgeben.However, it is also possible to produce the sharp-edged profiles 53 shown in FIG. 5 using a double-jaw molding tool, so that the sharp-edged shoulders also surround the entire piercing mandrel part in a ring.

Claims (7)

1. Tropfkammer für ein Infusions- oder Transfusionsgerät, die einen Einstechdorn zum Einstechen in den gummiartigen, elastischen Verschluss-Stopfen oder die Verschlussscheibe des Infusionsbehälters aufweist, der im Bereich seines spitz zulaufenden Endes mit einem Einflußloch versehen ist, dadurch gekennzeichnet, daß auf der Außenfläche des Einstechdorns (1) auf einem an das Einflußloch anschließenden Abschnitt (3) in Achsrichtung parallel aufeinander folgende umfangsmässig verlaufende Profilierungen (23, 33, 43, 53) ausgebildet sind.1. drip chamber for an infusion or transfusion device, which has a piercing spike for insertion into the rubber-like, elastic sealing plug or the sealing disc of the infusion container, which is provided with an influence hole in the region of its tapering end, characterized in that on the outer surface of the piercing mandrel (1) are formed on a section (3) adjoining the inflow hole in the axial direction, parallel to one another and following circumferential profiles (23, 33, 43, 53). 2. Tropfkammer nach Anspruch 1, dadurch gekennzeichnet, daß die Profilierungen der Einstechdorn ringförmig umgeben.2. Drip chamber according to claim 1, characterized in that the profiles of the piercing mandrel surround annular. 3. Tropfkammer nach Anspruch 1, dadurch gekennzeichnet, daß die Profilierungen den Einstechdorn halbkreisförmig umgeben.3. Drip chamber according to claim 1, characterized in that the profiles surround the piercing mandrel semicircular. 4. Tropfkammer nach Ansprüchen 1 - 3, dadurch gekennzeichnet, daß die Profilierungen durch eingebürstete feine parallele Rippen gebildet sind.4. drip chamber according to claims 1-3, characterized in that the profiles are formed by brushed fine parallel ribs. 5. Tropfkammer nach Ansprüchen 1 - 3, dadurch gekennzeichnet, daß die Profilierungen durch eingravierte parallele Rippen gebildet sind.5. drip chamber according to claims 1-3, characterized in that the profiles are formed by engraved parallel ribs. 6. Tropfkammer nach Ansprüchen 1 - 3, dadurch gekennzeichnet, daß die Profilierungen durch eingeformte scharfkantige Rippen gebildet sind.6. drip chamber according to claims 1-3, characterized in that the profiles are formed by molded-in sharp-edged ribs. 7. Tropfkammer nach einem oder mehreren der vorangehenden Ansprüche, dadurch gekennzeichnet, daß die Rippen im Querschnitt sägezahnförmig gestaltet sind.7. drip chamber according to one or more of the preceding claims, characterized in that the ribs are sawtooth-shaped in cross section.
EP80103563A 1979-06-26 1980-06-24 Drip chamber provided with a spike having an improved fitting ability Withdrawn EP0021405A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19797918241 DE7918241U1 (en) 1979-06-26 1979-06-26 DRIP CHAMBER WITH IMPROVED SEAT RESISTANCE OF THE DRIP CHAMBER SPIN
DE7918241U 1979-06-26

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EP0021405A1 true EP0021405A1 (en) 1981-01-07

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EP80103563A Withdrawn EP0021405A1 (en) 1979-06-26 1980-06-24 Drip chamber provided with a spike having an improved fitting ability

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DE (1) DE7918241U1 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006553A2 (en) * 1988-01-25 1989-07-27 Baxter International Inc. Pre-slit injection site and tapered cannula
EP0446463A1 (en) * 1990-03-15 1991-09-18 Bayer Ag Hollow mandrel in plastic material
JPH03504571A (en) * 1989-03-17 1991-10-09 バクスター　インターナショナル　インコーポレーテッド injection site
AU649832B2 (en) * 1988-01-25 1994-06-02 Baxter International Inc. Cannula insertion member
FR2743300A1 (en) * 1996-01-04 1997-07-11 Maco Pharma Sa Medical perfusion apparatus
US5658260A (en) 1988-01-25 1997-08-19 Baxter International Inc. Bayonet lock cannula for pre-slit y-site
US5776125A (en) 1991-07-30 1998-07-07 Baxter International Inc. Needleless vial access device
WO1999051288A1 (en) * 1998-04-07 1999-10-14 David Pesarin Electronic regulator for fluid therapy with disposable dripping cartridge
US6193697B1 (en) 1987-03-17 2001-02-27 Baxter International Inc. Pre-slit injection site and tapered cannula
DE102014218414A1 (en) * 2014-09-15 2016-03-17 B. Braun Melsungen Ag Closure assembly for a carrier housing a medical fluid storage and / or -leitungssystems

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1337891A (en) * 1962-07-10 1963-09-20 Debat Lab Device for the infusion of ready-to-use or extemporaneously obtained injectable pharmaceutical preparations
DE2221564A1 (en) * 1972-05-03 1973-11-15 Boehringer Mannheim Gmbh DEVICE FOR REMOVING INFUSION SOLUTIONS FROM INFUSION CONTAINERS
FR2375870A1 (en) * 1977-01-03 1978-07-28 Johnson & Johnson PERFECTED BLOOD FILTER

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1337891A (en) * 1962-07-10 1963-09-20 Debat Lab Device for the infusion of ready-to-use or extemporaneously obtained injectable pharmaceutical preparations
DE2221564A1 (en) * 1972-05-03 1973-11-15 Boehringer Mannheim Gmbh DEVICE FOR REMOVING INFUSION SOLUTIONS FROM INFUSION CONTAINERS
FR2375870A1 (en) * 1977-01-03 1978-07-28 Johnson & Johnson PERFECTED BLOOD FILTER

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6193697B1 (en) 1987-03-17 2001-02-27 Baxter International Inc. Pre-slit injection site and tapered cannula
US6217568B1 (en) 1988-01-25 2001-04-17 Edwards Lifesciences Corporation Preslit injection site and tapered cannula for blood sampling
US6569125B2 (en) 1988-01-25 2003-05-27 Baxter International Inc Pre-slit injection site and tapered cannula
US5658260A (en) 1988-01-25 1997-08-19 Baxter International Inc. Bayonet lock cannula for pre-slit y-site
US6605076B1 (en) 1988-01-25 2003-08-12 Baxter International Inc. Pre-slit injection site and tapered cannula
EP0544655A2 (en) * 1988-01-25 1993-06-02 Baxter International Inc. Cannula insertion member
EP0544655A3 (en) * 1988-01-25 1993-08-11 Baxter International Inc. Cannula insertion member
AU649832B2 (en) * 1988-01-25 1994-06-02 Baxter International Inc. Cannula insertion member
US5797897A (en) 1988-01-25 1998-08-25 Baxter International Inc. Pre-slit injection site and tapered cannula
US6447498B1 (en) 1988-01-25 2002-09-10 Baxter International Inc. Pre-slit injection site and tapered cannula
JPH02502976A (en) * 1988-01-25 1990-09-20 バクスター、インターナショナル、インコーポレイテッド Pre-slit injection site and tapered cannula
US6261266B1 (en) 1988-01-25 2001-07-17 Baxter International Inc. Pre-slit injection site and tapered cannula
US5871500A (en) 1988-01-25 1999-02-16 Baxter International Inc. Pre-slit injection site and tapered cannula
WO1989006553A2 (en) * 1988-01-25 1989-07-27 Baxter International Inc. Pre-slit injection site and tapered cannula
WO1989006553A3 (en) * 1988-01-25 1989-11-02 Baxter Int Pre-slit injection site and tapered cannula
JPH03504571A (en) * 1989-03-17 1991-10-09 バクスター　インターナショナル　インコーポレーテッド injection site
EP0446463A1 (en) * 1990-03-15 1991-09-18 Bayer Ag Hollow mandrel in plastic material
US5776125A (en) 1991-07-30 1998-07-07 Baxter International Inc. Needleless vial access device
FR2743300A1 (en) * 1996-01-04 1997-07-11 Maco Pharma Sa Medical perfusion apparatus
WO1999051288A1 (en) * 1998-04-07 1999-10-14 David Pesarin Electronic regulator for fluid therapy with disposable dripping cartridge
DE102014218414A1 (en) * 2014-09-15 2016-03-17 B. Braun Melsungen Ag Closure assembly for a carrier housing a medical fluid storage and / or -leitungssystems

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Publication number Publication date
DE7918241U1 (en) 1980-12-11

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