DE938893T1 - Zelleinkapselungsvorrichtung - Google Patents

Zelleinkapselungsvorrichtung

Info

Publication number
DE938893T1
DE938893T1 DE0938893T DE98124882T DE938893T1 DE 938893 T1 DE938893 T1 DE 938893T1 DE 0938893 T DE0938893 T DE 0938893T DE 98124882 T DE98124882 T DE 98124882T DE 938893 T1 DE938893 T1 DE 938893T1
Authority
DE
Germany
Prior art keywords
permeable membrane
core
devices
cells
zone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0938893T
Other languages
English (en)
Other versions
DE19824882A1 (de
Inventor
Mark D Butler
Stanley L Mish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WL Gore and Associates Inc
Original Assignee
WL Gore and Associates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WL Gore and Associates Inc filed Critical WL Gore and Associates Inc
Publication of DE938893T1 publication Critical patent/DE938893T1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
  • Optical Measuring Cells (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
  • Transplanting Machines (AREA)
DE0938893T 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung Pending DE938893T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10501193A 1993-08-10 1993-08-10

Publications (1)

Publication Number Publication Date
DE938893T1 true DE938893T1 (de) 2000-03-09

Family

ID=22303587

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69433970T Expired - Lifetime DE69433970T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung
DE0938893T Pending DE938893T1 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung
DE69420024T Expired - Lifetime DE69420024T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69433970T Expired - Lifetime DE69433970T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69420024T Expired - Lifetime DE69420024T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung

Country Status (9)

Country Link
US (2) US5980889A (de)
EP (2) EP0938893B1 (de)
AT (2) ATE183078T1 (de)
AU (1) AU678843B2 (de)
CA (1) CA2147626C (de)
DE (3) DE69433970T2 (de)
DK (1) DK0663817T3 (de)
ES (1) ES2138665T3 (de)
WO (1) WO1995004521A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0663817T3 (da) * 1993-08-10 2000-03-13 Gore & Ass Celleindkapslingsindretning
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
AU6854696A (en) * 1995-09-22 1997-04-09 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US5952226A (en) * 1996-11-05 1999-09-14 Modex Therapeutiques Hypoxia responsive EPO producing cells
US6306491B1 (en) * 1996-12-20 2001-10-23 Gore Enterprise Holdings, Inc. Respiratory aids
US6368858B1 (en) * 1997-07-22 2002-04-09 The General Hospital Corporation Modulation of multicellular aggregates by pressure from growth in a matrix
US6287558B1 (en) * 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6984635B1 (en) 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US20010031974A1 (en) * 2000-01-31 2001-10-18 Hadlock Theresa A. Neural regeneration conduit
CA2365376C (en) * 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6852330B2 (en) * 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6599323B2 (en) * 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
US20020127265A1 (en) * 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CZ298160B6 (cs) * 2001-01-18 2007-07-11 Prístroj pro vyvolání imunitní odezvy pri lécbe rakoviny
WO2002100335A2 (en) * 2001-06-08 2002-12-19 Boehringer Ingelheim Pharmaceuticals, Inc. Methods for improving cell line activity in immunoisolation devices
WO2003015615A2 (en) 2001-08-15 2003-02-27 Brown University Research Foundation Treatment of muscular dystrophies and related disorders
TW200307129A (en) 2002-02-08 2003-12-01 Xcyte Therapies Inc Compositions and methods for restoring immune responsiveness in patients with immunological defects
US20030170278A1 (en) * 2002-03-11 2003-09-11 Wolf David E. Microreactor and method of determining a microreactor suitable for a predetermined mammal
CA2490401A1 (en) 2002-06-28 2004-01-08 Xcyte Therapies, Inc. Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
WO2004075855A2 (en) 2003-02-26 2004-09-10 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluid
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
MXPA05012080A (es) * 2003-05-08 2006-02-22 Xcyte Therapies Inc Generacion y aislamiento de celulas t especificas al antigeno.
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
GB2407394A (en) 2003-10-23 2005-04-27 Dow Corning Ltd Optical waveguide with two differently dimensioned waveguiding layers on substrate
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8657881B2 (en) 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US20060257368A1 (en) * 2005-05-03 2006-11-16 Clemson University Devices and methods for improved viability of cells
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
US20100080784A1 (en) * 2008-09-12 2010-04-01 Torrey Pines Institute For Molecular Studies Methods for treating cachexia and lymphopenia
JP5897335B2 (ja) 2009-01-23 2016-03-30 エヌエスジーン・アクティーゼルスカブＮｓＧｅｎｅ Ａ／Ｓ 改良された細胞株及びカプセル化細胞生体送達におけるその使用
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
DK2621403T3 (en) 2010-09-27 2015-06-15 Nsgene As An implantable cell device with supporting and radial diffusible structure
AU2011352228B2 (en) 2010-12-27 2015-12-03 Brown University Therapeutic and diagnostic methods involving biglycan and utrophin
KR20140066218A (ko) * 2011-09-06 2014-05-30 스템 셀 써지컬 엘엘씨 수술용 봉합재, 이를 제조하는 방법, 및 이를 사용하는 방법
EP3696262A1 (de) 2011-11-23 2020-08-19 The Trustees Of The University Of Pennsylvania Verwendung von pdl1-exprimierenden zellen zur umwandlung von t-zellen in regulatorische t-zellen
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US9610546B2 (en) 2014-03-12 2017-04-04 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US10376845B2 (en) 2016-04-14 2019-08-13 Lockheed Martin Corporation Membranes with tunable selectivity
US10980919B2 (en) 2016-04-14 2021-04-20 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
TW201504140A (zh) 2013-03-12 2015-02-01 Lockheed Corp 形成具有均勻孔尺寸之多孔石墨烯之方法
ES2786253T3 (es) 2013-03-14 2020-10-09 Immusoft Corp Métodos para la diferenciación y transducción in vitro de células b de memoria con vectores virales pseudotipados vsv-g
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
CN105940479A (zh) 2014-01-31 2016-09-14 洛克希德马丁公司 使用宽离子场穿孔二维材料
CA2938305A1 (en) 2014-01-31 2015-08-06 Lockheed Martin Corporation Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
JP2017512129A (ja) 2014-03-12 2017-05-18 ロッキード・マーチン・コーポレーション 有孔グラフェンから形成された分離膜
EP3188823A4 (de) 2014-09-02 2018-04-25 Lockheed Martin Corporation Hämodialyse- und hämofiltrationsmembranen basierend auf einem zweidimensionalen membranmaterial und verfahren zur verwendung davon
JP6879910B2 (ja) 2014-10-31 2021-06-02 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｃａｒｔ細胞における遺伝子発現の改変およびその使用
CA2966035A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Compositions and methods of stimulating and expanding t cells
EP3234107B1 (de) 2014-12-19 2022-09-14 Immusoft Corporation B-zellen zur in-vivo-verabreichung von therapeutika
AU2015380397B2 (en) 2015-01-31 2021-10-21 The Trustees Of The University Of Pennsylvania Compositions and methods for T cell delivery of therapeutic molecules
AU2016220324B2 (en) 2015-02-16 2020-07-02 The Trustees Of The University Of Pennsylvania A fully-human T cell receptor specific for the 369-377 epitope derived from the HER2/Neu (ERBB2) receptor protein
AU2016303048A1 (en) 2015-08-05 2018-03-01 Lockheed Martin Corporation Perforatable sheets of graphene-based material
AU2016303049A1 (en) 2015-08-06 2018-03-01 Lockheed Martin Corporation Nanoparticle modification and perforation of graphene
WO2017147431A1 (en) * 2016-02-24 2017-08-31 Georgia Tech Research Corporation Surgical suture materials with porous sheaths for drug delivery
EP3443329A4 (de) 2016-04-14 2020-04-08 Lockheed Martin Corporation Verfahren zur in-situ-überwachung und -steuerung der defektbildung oder heilung
JP2019521055A (ja) 2016-04-14 2019-07-25 ロッキード・マーチン・コーポレーション グラフェン欠陥の選択的界面緩和
EP3442786A4 (de) 2016-04-14 2020-03-18 Lockheed Martin Corporation Zweidimensionale membranstrukturen mit strömungskanälen
CA3020686A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Method for treating graphene sheets for large-scale transfer using free-float method
WO2018003858A1 (ja) * 2016-06-28 2018-01-04 国立研究開発法人農業・食品産業技術総合研究機構 細胞封入用デバイス及びその使用
KR20230037059A (ko) 2016-11-03 2023-03-15 아리조나 보드 오브 리전츠 온 비해프 오브 더 유니버시티 오브 아리조나 외부 산소 전달을 수반 또는 비-수반하는 산소 센서가 구비된 캡슐화 장치 시스템
AU2017396754B2 (en) 2016-11-03 2021-08-05 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre-and post-transplantation
US11052230B2 (en) 2016-11-08 2021-07-06 W. L. Gore & Associates, Inc. Implantable encapsulation devices
US11707611B2 (en) 2016-11-08 2023-07-25 W. L. Gore & Associates, Inc. Implantable apparatus for retention of biological moieties
JP7088564B2 (ja) 2016-11-10 2022-06-21 ヴィアサイト，インコーポレイテッド 細胞送達装置におけるｐｄｘ１膵臓内胚葉細胞及びその方法
CN111936617A (zh) 2018-03-16 2020-11-13 益缪索夫特公司 经遗传工程化以分泌卵泡抑素的b细胞以及使用所述b细胞来治疗卵泡抑素相关的疾病、病况、病症及增强肌肉生长和力量的方法
AU2019297451A1 (en) 2018-07-03 2021-01-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
WO2020068852A1 (en) * 2018-09-24 2020-04-02 Procyon Technologies Llc Methods and systems for implantable medical devices and vascularization membranes

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993072A (en) * 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
CA1085104A (en) * 1977-03-21 1980-09-09 Anthony M. Sun Artificial endocrine pancreas
US4743545A (en) * 1984-08-09 1988-05-10 Torobin Leonard B Hollow porous microspheres containing biocatalyst
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4420589A (en) * 1980-07-07 1983-12-13 Stoy Vladimir A Polymer composition including polyacrylonitrile polymers and process for preparing same
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4495288A (en) * 1981-03-13 1985-01-22 Damon Biotech, Inc. Method of culturing anchorage dependent cells
US4378016A (en) * 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
JPS59501747A (ja) * 1982-09-29 1984-10-18 スピ−ルバ−グ　セオドア−　イ− カプセル封入された、治療物質産生性の遺伝子操作された生物
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
AU3542684A (en) * 1983-11-15 1985-05-23 Johnson & Johnson Corporation Glycemia regulating implant
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4722898A (en) * 1985-04-29 1988-02-02 Minnesota Mining And Manufacturing Company Immobilization of biological cells in polytetrafluoroethylene matrix
US4902295A (en) * 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
AU589438B2 (en) * 1985-08-26 1989-10-12 Hana Biologics, Inc. Transplantable artificial tissue and process
US4997443A (en) * 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
US5030225A (en) * 1987-03-13 1991-07-09 Brown University Research Foundation Electrically-charged nerve guidance channels
US5218039A (en) * 1987-04-28 1993-06-08 Kingston Technologies, Inc. Pan emulsion
US4911717A (en) * 1987-06-18 1990-03-27 Gaskill Iii Harold V Intravasular artificial organ
US4942129A (en) * 1987-07-28 1990-07-17 Queen's University At Kingston Multiple membrane microencapsulation
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
EP0331521A3 (de) * 1988-03-04 1991-01-23 Kingston Technologies, Inc. Polyakrylonitrilmischung und Verfahren zu ihrer Herstellung
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
US4941812A (en) * 1988-05-10 1990-07-17 E. I. Du Pont De Nemours And Company Spinneret for production of a hollow filament within a hollow filament composite fiber having spacing means
FR2634382B1 (fr) * 1988-07-21 1990-10-26 Applic Techn Photoniques Pancreas artificiel
AU4071789A (en) * 1988-08-12 1990-03-05 Cell Biotech, Inc. Process for purification of islet cells; monoclonal antibodies directed to islet and acinar cells; and process for making and using same
CA1323959C (en) * 1988-09-16 1993-11-09 Andreas F. Von Recum Soft tissue implant with micron-scale surface texture to optimize anchorage
US5011486A (en) * 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5017490A (en) * 1989-03-10 1991-05-21 Baxter International Inc. Method for in vitro reproduction and growth of cells in culture medium
DE69017820T2 (de) * 1989-04-25 1995-10-05 Childrens Medical Center Implantaten für grosse mengen von zellen auf polymerische matrizen.
EP0478671B1 (de) * 1989-06-21 1993-05-19 Brown University Research Foundation Neurologisches therapiesystem
WO1991000119A1 (en) * 1989-06-30 1991-01-10 Baxter International Inc. Implantable device
US5002661A (en) * 1989-08-25 1991-03-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device
US5116493A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5116494A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with temperature sensitive matrix
US5100392A (en) * 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
WO1991010470A1 (en) * 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US4969705A (en) * 1990-01-19 1990-11-13 Kingston Technologies, L.P. Memory polymer multiple cavity fiber splicer
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US5256418A (en) * 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
WO1992007525A1 (en) * 1990-10-31 1992-05-14 Baxter International Inc. Close vascularization implant material
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
DE4108772A1 (de) * 1991-03-18 1992-09-24 Inst Textil & Faserforschung Implantierbares biohybrides organ
EP0585368B1 (de) * 1991-04-25 1997-08-06 Brown University Research Foundation Implantierbare, biokompatible immunisolator-trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
US5453278A (en) * 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
US5116753A (en) * 1991-07-30 1992-05-26 The Salk Institute For Biological Studies Maintenance of pancreatic islets
WO1993008850A1 (en) * 1991-10-30 1993-05-13 Massachusetts Institute Of Technology Prevascularized polymeric implants for organ transplantation
DK0676935T3 (da) * 1992-04-01 2001-12-27 Baxter Int Angiogeniske vævsimplantatsystemer
EP0640126A1 (de) * 1992-04-24 1995-03-01 Somatix Therapy Corporation Verfahren zur Züchtung lebender Zellen und Methode zur Regulation des Ghaltes einer verbindung in einer Körperflussigkeit
AU4114993A (en) * 1992-04-24 1993-11-29 Polymer Technology Group, Inc., The Biocompatible, therapeutic, implantable device
WO1994007999A1 (en) * 1992-09-28 1994-04-14 Brown University Research Foundation Chitosan matrices for encapsulated cells
DK0663817T3 (da) * 1993-08-10 2000-03-13 Gore & Ass Celleindkapslingsindretning
EP0688196B1 (de) * 1994-01-11 2002-04-17 Baxter International Inc. Offenes gewebe-implantat-system

Also Published As

Publication number Publication date
WO1995004521A1 (en) 1995-02-16
EP0663817B1 (de) 1999-08-11
ATE183078T1 (de) 1999-08-15
CA2147626A1 (en) 1995-02-16
DE69433970D1 (de) 2004-09-30
CA2147626C (en) 1998-04-21
DE69420024T2 (de) 2000-02-24
EP0938893A1 (de) 1999-09-01
DE69433970T2 (de) 2005-08-11
EP0663817A1 (de) 1995-07-26
ATE274340T1 (de) 2004-09-15
US5980889A (en) 1999-11-09
EP0938893B1 (de) 2004-08-25
AU678843B2 (en) 1997-06-12
ES2138665T3 (es) 2000-01-16
AU7356394A (en) 1995-02-28
DE69420024D1 (de) 1999-09-16
US6426214B1 (en) 2002-07-30
DK0663817T3 (da) 2000-03-13

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