DE69941510D1 - Differenzierung von nicht-insulin in insulin-produzierende zellen durch glp-1 und exendin-4 und dessen verwendung - Google Patents

Differenzierung von nicht-insulin in insulin-produzierende zellen durch glp-1 und exendin-4 und dessen verwendung

Info

Publication number
DE69941510D1
DE69941510D1 DE69941510T DE69941510T DE69941510D1 DE 69941510 D1 DE69941510 D1 DE 69941510D1 DE 69941510 T DE69941510 T DE 69941510T DE 69941510 T DE69941510 T DE 69941510T DE 69941510 D1 DE69941510 D1 DE 69941510D1
Authority
DE
Germany
Prior art keywords
insulin
producing cells
exendin
glp
differentiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69941510T
Other languages
English (en)
Inventor
Josephine Egan
Riccardo Perfetti
Antonino Passaniti
Nigel Greig
Harold Holloway
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institutes of Health NIH
Original Assignee
National Institutes of Health NIH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institutes of Health NIH filed Critical National Institutes of Health NIH
Application granted granted Critical
Publication of DE69941510D1 publication Critical patent/DE69941510D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/335—Glucagon; Glucagon-like peptide [GLP]; Exendin
DE69941510T 1998-08-10 1999-08-10 Differenzierung von nicht-insulin in insulin-produzierende zellen durch glp-1 und exendin-4 und dessen verwendung Expired - Lifetime DE69941510D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9591798P 1998-08-10 1998-08-10
PCT/US1999/018099 WO2000009666A2 (en) 1998-08-10 1999-08-10 Differentiation of non-insulin producing cells into insulin producing cells by glp-1 or exendin-4 and uses thereof

Publications (1)

Publication Number Publication Date
DE69941510D1 true DE69941510D1 (de) 2009-11-19

Family

ID=22254191

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69941510T Expired - Lifetime DE69941510D1 (de) 1998-08-10 1999-08-10 Differenzierung von nicht-insulin in insulin-produzierende zellen durch glp-1 und exendin-4 und dessen verwendung

Country Status (10)

Country Link
US (2) US7056734B1 (de)
EP (2) EP2028269B1 (de)
JP (4) JP4624558B2 (de)
AT (1) ATE445006T1 (de)
AU (1) AU776514B2 (de)
CA (1) CA2339326A1 (de)
DE (1) DE69941510D1 (de)
DK (1) DK1105460T3 (de)
ES (2) ES2553108T3 (de)
WO (1) WO2000009666A2 (de)

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Also Published As

Publication number Publication date
JP4755133B2 (ja) 2011-08-24
CA2339326A1 (en) 2000-02-24
AU776514B2 (en) 2004-09-09
EP2028269A1 (de) 2009-02-25
EP1105460B1 (de) 2009-10-07
ATE445006T1 (de) 2009-10-15
WO2000009666A9 (en) 2000-07-13
JP2002522068A (ja) 2002-07-23
JP2007209348A (ja) 2007-08-23
US20070041951A1 (en) 2007-02-22
ES2335066T3 (es) 2010-03-18
WO2000009666A2 (en) 2000-02-24
DK1105460T3 (da) 2010-02-08
JP2009291206A (ja) 2009-12-17
ES2553108T3 (es) 2015-12-04
AU5552499A (en) 2000-03-06
JP4624558B2 (ja) 2011-02-02
EP1105460A2 (de) 2001-06-13
JP2011177181A (ja) 2011-09-15
WO2000009666A3 (en) 2000-11-23
US7056734B1 (en) 2006-06-06
EP2028269B1 (de) 2015-10-21

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