DE69939327D1 - Funktionelle antagonisten von hedgehog-aktivität - Google Patents

Funktionelle antagonisten von hedgehog-aktivität

Info

Publication number
DE69939327D1
DE69939327D1 DE69939327T DE69939327T DE69939327D1 DE 69939327 D1 DE69939327 D1 DE 69939327D1 DE 69939327 T DE69939327 T DE 69939327T DE 69939327 T DE69939327 T DE 69939327T DE 69939327 D1 DE69939327 D1 DE 69939327D1
Authority
DE
Germany
Prior art keywords
hedgehog
functional antagonists
variants
ability
hedgehog activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939327T
Other languages
English (en)
Inventor
Kevin Williams
Paul Rayhorn
Ellen A Garber
Blake R Pepinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curis Inc
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Application granted granted Critical
Publication of DE69939327D1 publication Critical patent/DE69939327D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE69939327T 1998-11-02 1999-11-02 Funktionelle antagonisten von hedgehog-aktivität Expired - Lifetime DE69939327D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10670398P 1998-11-02 1998-11-02
PCT/US1999/025700 WO2000025725A2 (en) 1998-11-02 1999-11-02 Functional antagonists of hedgehog activity

Publications (1)

Publication Number Publication Date
DE69939327D1 true DE69939327D1 (de) 2008-09-25

Family

ID=22312815

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939327T Expired - Lifetime DE69939327D1 (de) 1998-11-02 1999-11-02 Funktionelle antagonisten von hedgehog-aktivität

Country Status (9)

Country Link
US (1) US8410061B2 (de)
EP (1) EP1133519B1 (de)
JP (1) JP4574012B2 (de)
AT (1) ATE404583T1 (de)
AU (1) AU765485B2 (de)
CA (1) CA2348773C (de)
DE (1) DE69939327D1 (de)
IL (2) IL142905A0 (de)
WO (1) WO2000025725A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69841320D1 (de) 1997-02-10 2010-01-07 Harvard College Verfahren zur modulation von hämatopoese und vaskulärem wachstum
IL136230A0 (en) * 1997-11-28 2001-05-20 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
IL146842A0 (en) * 1999-06-01 2002-07-25 Biogen Inc Polymer conjugates of hedgehog proteins and uses
WO2000074706A1 (en) * 1999-06-08 2000-12-14 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
US7479539B1 (en) 1999-11-05 2009-01-20 Curis, Inc. Hedgehog fusion proteins
AU2005203058C1 (en) * 1999-11-05 2009-07-02 Curis, Inc. Hedgehog fusion proteins and uses
US8168178B2 (en) 1999-11-30 2012-05-01 Curis, Inc. Methods and compositions for regulating lymphocyte activity
JP4954426B2 (ja) * 2000-06-16 2012-06-13 キュリス，インコーポレイテッド 血管形成調節組成物及び利用
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
AU2001276722A1 (en) * 2000-08-04 2002-02-18 Takeda Chemical Industries Ltd. Use of gli1 gene
AU9684401A (en) 2000-10-13 2002-04-22 Curis Inc Hedgehog antagonists, methods and uses related thereto
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
CA2561221C (en) 2004-03-26 2016-09-20 Curis, Inc. Rna interference modulators of hedgehog signaling and uses thereof
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
ES2618785T3 (es) 2005-10-31 2017-06-22 Oncomed Pharmaceuticals, Inc. Composiciones y métodos para tratar el cáncer basados en receptores FZD humanos
EP1945754B1 (de) 2005-10-31 2014-07-23 The Regents Of The University Of Michigan Zusammensetzungen und verfahren zur behandlung und diagnostizierung von krebs
US8026354B2 (en) 2005-11-23 2011-09-27 Institut Pasteur Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use
US8148147B2 (en) 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
PT2331136T (pt) 2008-09-26 2018-03-27 Oncomed Pharm Inc Agentes de ligação a frizzled e utilizações dos mesmos
RU2561055C2 (ru) 2009-08-25 2015-08-20 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Комбинированная терапия композициями наночастиц таксана и ингибиторами хэджхог
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
KR20130043102A (ko) 2010-04-01 2013-04-29 온코메드 파마슈티칼스, 인크. 프리즐드-결합 작용제 및 그의 용도
AU2013334790A1 (en) 2012-10-23 2015-04-30 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using Wnt pathway-binding agents
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
WO2015036405A1 (en) 2013-09-10 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating basal cell carcinoma
US9814703B2 (en) 2013-11-14 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of BMP signaling

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610656B1 (en) 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US6261786B1 (en) 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US6165747A (en) 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US7060450B1 (en) 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US20030186357A1 (en) 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US6384192B1 (en) 1993-12-30 2002-05-07 President & Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins
US6884775B1 (en) 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
CA2184092A1 (en) 1994-02-25 1995-08-31 Thomas M. Jessell Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof
DK0935656T3 (da) 1996-09-20 2006-12-11 Harvard College Hedgehog interagerende proteiner og anvendelser relateret dertil
US5759811A (en) * 1996-11-13 1998-06-02 The Regents Of The University Of California Mutant human hedgehog gene
AU8173098A (en) * 1997-06-27 1999-01-19 Ontogeny, Inc. Neuroprotective methods and reagents
US6287558B1 (en) 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6639051B2 (en) 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
CA2309806A1 (en) * 1997-12-03 1999-06-10 Biogen, Inc. Hydrophobically-modified protein compositions and methods
WO2000018428A2 (en) * 1998-09-11 2000-04-06 Biogen, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
IL146842A0 (en) 1999-06-01 2002-07-25 Biogen Inc Polymer conjugates of hedgehog proteins and uses

Also Published As

Publication number Publication date
WO2000025725A3 (en) 2000-11-30
US8410061B2 (en) 2013-04-02
AU2144500A (en) 2000-05-22
JP4574012B2 (ja) 2010-11-04
US20030166543A1 (en) 2003-09-04
IL142905A0 (en) 2002-04-21
EP1133519A2 (de) 2001-09-19
EP1133519B1 (de) 2008-08-13
CA2348773A1 (en) 2000-05-11
IL142905A (en) 2009-12-24
ATE404583T1 (de) 2008-08-15
AU765485B2 (en) 2003-09-18
JP2002534060A (ja) 2002-10-15
WO2000025725A2 (en) 2000-05-11
CA2348773C (en) 2010-04-13

Similar Documents

Publication Publication Date Title
DE69939327D1 (de) Funktionelle antagonisten von hedgehog-aktivität
AU4981101A (en) Subtilisin variants
NO964650L (no) LAG-3 proteinopploselige polypeptidfraksjoner, fremgangsmate for fremstilling, terapeutisk preparat og anti-idiotype antistoff
DK1482042T3 (da) Aktive og inaktive CC-kemokinreceptorer og nukleinsyremolekyler der koder for receptoren
CY1107821T1 (el) Πολυπεπτιδιο παραγοντα viii με ενεργοτητα παραγοντα viii:c
ATE175446T1 (de) Immunogene peptide, antikörper sowie deren verwendungen im zusammenhang mit der cd4- rezeptorbindung
NZ504548A (en) Polypeptides and nucleic acids encoding human chordin
DK0479948T3 (da) Sammensætninger og fremgangsmåder til syntese af natriuretisk protein-receptor B og anvendelsesfremgangsmåder
BG104149A (en) Interleukin-18-binding proteins, methods for their preparation and administration
EP0679093A1 (de) Methode zum überbringen von agenzien an zielzellen.
SE9901379D0 (sv) Receptor structures
NZ501767A (en) Cyclic integrin binding peptide with the amino acid sequence RKK
NZ236511A (en) Polypeptides containing sequences from residues 61 to 82 or 104 to 129 of human il-4 or subsequences thereof; antibodies and pharmaceutical compositions
UA65561A (en) Therapeutic agent for lymphatic tumors
RS49517B (sr) PEPTID p277-ANALOZI I FARMACEUTSKI PREPARATI KOJI GA SADRZE
ATE364048T1 (de) Peptide von carcinoembryonischem antigen (cea) mit tachykinin-antagonistischer aktivität
WO2002044197A3 (en) Cytokine receptor binding peptides
DK258789A (da) Peptider, der blokerer bindingen af hiv-1 til cd4 receptorproteinet
PT1007559E (pt) Celulas geneticamente modificadas que expressam as proteinas morfogeneticas do osso
NO984491L (no) SCF-analogpreparater og fremgangsmÕte for fremstilling av disse
ATE287952T1 (de) Humanes thymosin beta 15 gen,protein und dessen verwendungen
DK0990703T3 (da) Nyt polypeptid, DNA, som koder herfor, samt anvendelse heraf
SE9602822D0 (sv) New receptor
IL129139A0 (en) Vertebrate smoothened proteins
ATE294816T1 (de) Neue, physiologisch aktive peptide und ihre verwendung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition