DE69939327D1 - Funktionelle antagonisten von hedgehog-aktivität - Google Patents
Funktionelle antagonisten von hedgehog-aktivitätInfo
- Publication number
- DE69939327D1 DE69939327D1 DE69939327T DE69939327T DE69939327D1 DE 69939327 D1 DE69939327 D1 DE 69939327D1 DE 69939327 T DE69939327 T DE 69939327T DE 69939327 T DE69939327 T DE 69939327T DE 69939327 D1 DE69939327 D1 DE 69939327D1
- Authority
- DE
- Germany
- Prior art keywords
- hedgehog
- functional antagonists
- variants
- ability
- hedgehog activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005557 antagonist Substances 0.000 title abstract 4
- 241000027355 Ferocactus setispinus Species 0.000 title 1
- 241000289669 Erinaceus europaeus Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 101000606317 Drosophila melanogaster Protein patched Proteins 0.000 abstract 1
- 102000003693 Hedgehog Proteins Human genes 0.000 abstract 1
- 108090000031 Hedgehog Proteins Proteins 0.000 abstract 1
- 102000012850 Patched-1 Receptor Human genes 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000011191 terminal modification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10670398P | 1998-11-02 | 1998-11-02 | |
PCT/US1999/025700 WO2000025725A2 (en) | 1998-11-02 | 1999-11-02 | Functional antagonists of hedgehog activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69939327D1 true DE69939327D1 (de) | 2008-09-25 |
Family
ID=22312815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69939327T Expired - Lifetime DE69939327D1 (de) | 1998-11-02 | 1999-11-02 | Funktionelle antagonisten von hedgehog-aktivität |
Country Status (9)
Country | Link |
---|---|
US (1) | US8410061B2 (de) |
EP (1) | EP1133519B1 (de) |
JP (1) | JP4574012B2 (de) |
AT (1) | ATE404583T1 (de) |
AU (1) | AU765485B2 (de) |
CA (1) | CA2348773C (de) |
DE (1) | DE69939327D1 (de) |
IL (2) | IL142905A0 (de) |
WO (1) | WO2000025725A2 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998035020A2 (en) | 1997-02-10 | 1998-08-13 | The Presidents And Fellows Of Harvard College | Methods for modulating hematopoiesis and vascular growth |
JP2001525341A (ja) * | 1997-11-28 | 2001-12-11 | ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 活性ヘッジホッグタンパク質変異体、その調製方法及び医薬への適用 |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
CA2375700A1 (en) * | 1999-06-01 | 2000-12-07 | Biogen, Inc. | Polymer conjugates of hedgehog proteins and uses |
ATE283700T1 (de) * | 1999-06-08 | 2004-12-15 | Lorantis Ltd | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
AU780693B2 (en) * | 1999-11-05 | 2005-04-14 | Curis, Inc. | Hedgehog fusion proteins and uses |
AU2005203058C1 (en) * | 1999-11-05 | 2009-07-02 | Curis, Inc. | Hedgehog fusion proteins and uses |
US8168178B2 (en) | 1999-11-30 | 2012-05-01 | Curis, Inc. | Methods and compositions for regulating lymphocyte activity |
US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
JP4954426B2 (ja) * | 2000-06-16 | 2012-06-13 | キュリス,インコーポレイテッド | 血管形成調節組成物及び利用 |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
AU2001276722A1 (en) * | 2000-08-04 | 2002-02-18 | Takeda Chemical Industries Ltd. | Use of gli1 gene |
US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
US20040060568A1 (en) | 2000-10-13 | 2004-04-01 | Henryk Dudek | Hedgehog antagonists, methods and uses related thereto |
US7663017B2 (en) | 2003-07-30 | 2010-02-16 | Institut Pasteur | Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications |
JP5184077B2 (ja) | 2004-03-26 | 2013-04-17 | キュリス,インコーポレイテッド | ヘッジホッグシグナリングのrna干渉モジュレーター及びその利用 |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
JP2009513708A (ja) | 2005-10-31 | 2009-04-02 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 癌の診断および処置のための組成物および方法 |
JP5129149B2 (ja) | 2005-10-31 | 2013-01-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌を処置および診断するための組成物および方法 |
US8026354B2 (en) | 2005-11-23 | 2011-09-27 | Institut Pasteur | Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use |
WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
AU2009296246B2 (en) | 2008-09-26 | 2015-07-30 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
US20130045240A1 (en) | 2009-08-25 | 2013-02-21 | Abraxis Bioscience, Llc | Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
CN102971337B (zh) | 2010-04-01 | 2016-09-21 | 昂考梅德药品有限公司 | 卷曲蛋白结合药剂及其应用 |
CA2887711A1 (en) | 2012-10-23 | 2014-05-01 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
WO2015036405A1 (en) | 2013-09-10 | 2015-03-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating basal cell carcinoma |
US9814703B2 (en) | 2013-11-14 | 2017-11-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of BMP signaling |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610656B1 (en) | 1993-12-30 | 2003-08-26 | President And Fellows Of Harvard College | Method of promoting chondrocyte differentiation with hedgehog related polypeptides |
US5789543A (en) | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
US6261786B1 (en) | 1993-12-30 | 2001-07-17 | Imperial Cancer Res. Technology | Screening assays for hedgehog agonists and antagonists |
US6271363B1 (en) | 1993-12-30 | 2001-08-07 | President & Fellows Of Harvard College | Nucleic acids encoding hedgehog proteins |
US7060450B1 (en) | 1993-12-30 | 2006-06-13 | President And Fellows Of Harvard College | Screening assays for agonists and antagonists of the hedgehog signaling pathway |
US20030186357A1 (en) | 1993-12-30 | 2003-10-02 | Philip W. Ingham | Vertebrate embryonic pattern-inducing proteins, and uses related thereto |
US6165747A (en) | 1993-12-30 | 2000-12-26 | President & Fellows Of Harvard College | Nucleic acids encoding hedgehog proteins |
US6884775B1 (en) | 1993-12-30 | 2005-04-26 | President And Fellows Of Harvard College | Methods and compositions for regulating skeletogenic formation |
JPH09509574A (ja) | 1994-02-25 | 1997-09-30 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | 脊索によって発現されるヘッジホッグ、Vhh−1、の脊椎動物相同体をコードするDNA、及びこれらの使用 |
IL128999A0 (en) | 1996-09-20 | 2000-02-17 | Harvard College | Hedgehog interacting proteins and uses related thereto |
US5759811A (en) * | 1996-11-13 | 1998-06-02 | The Regents Of The University Of California | Mutant human hedgehog gene |
WO1999000117A2 (en) * | 1997-06-27 | 1999-01-07 | Ontogeny, Inc. | Neuroprotective methods and reagents |
US6287558B1 (en) | 1997-08-01 | 2001-09-11 | Biohybrio Technologies Llc | Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule |
US6639051B2 (en) | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
DE69830192T2 (de) * | 1997-12-03 | 2006-01-12 | Biogen Idec Ma Inc., Cambridge | Hydrophobisch-modifizierte Hedgehog Protein Zusammensetzungen und Verfahren |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
ATE458497T1 (de) | 1998-09-11 | 2010-03-15 | Curis Inc | Antagonisten von 'hedgehog' und 'patched' zur inhibierung des wachstums und der differenzierung von zellen und geweben, als auch deren verwendungen |
CA2375700A1 (en) | 1999-06-01 | 2000-12-07 | Biogen, Inc. | Polymer conjugates of hedgehog proteins and uses |
-
1999
- 1999-11-02 DE DE69939327T patent/DE69939327D1/de not_active Expired - Lifetime
- 1999-11-02 CA CA2348773A patent/CA2348773C/en not_active Expired - Fee Related
- 1999-11-02 EP EP99965744A patent/EP1133519B1/de not_active Expired - Lifetime
- 1999-11-02 AU AU21445/00A patent/AU765485B2/en not_active Ceased
- 1999-11-02 IL IL14290599A patent/IL142905A0/xx unknown
- 1999-11-02 JP JP2000579170A patent/JP4574012B2/ja not_active Expired - Fee Related
- 1999-11-02 WO PCT/US1999/025700 patent/WO2000025725A2/en active IP Right Grant
- 1999-11-02 AT AT99965744T patent/ATE404583T1/de not_active IP Right Cessation
-
2001
- 2001-05-01 IL IL142905A patent/IL142905A/en not_active IP Right Cessation
-
2002
- 2002-06-05 US US10/164,282 patent/US8410061B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE404583T1 (de) | 2008-08-15 |
AU765485B2 (en) | 2003-09-18 |
US8410061B2 (en) | 2013-04-02 |
WO2000025725A2 (en) | 2000-05-11 |
AU2144500A (en) | 2000-05-22 |
IL142905A0 (en) | 2002-04-21 |
JP4574012B2 (ja) | 2010-11-04 |
CA2348773A1 (en) | 2000-05-11 |
IL142905A (en) | 2009-12-24 |
EP1133519A2 (de) | 2001-09-19 |
EP1133519B1 (de) | 2008-08-13 |
CA2348773C (en) | 2010-04-13 |
WO2000025725A3 (en) | 2000-11-30 |
US20030166543A1 (en) | 2003-09-04 |
JP2002534060A (ja) | 2002-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |