DE69939259D1 - Gerät zur überwachung der polymerase-ketten reaktion von dna - Google Patents
Gerät zur überwachung der polymerase-ketten reaktion von dnaInfo
- Publication number
- DE69939259D1 DE69939259D1 DE69939259T DE69939259T DE69939259D1 DE 69939259 D1 DE69939259 D1 DE 69939259D1 DE 69939259 T DE69939259 T DE 69939259T DE 69939259 T DE69939259 T DE 69939259T DE 69939259 D1 DE69939259 D1 DE 69939259D1
- Authority
- DE
- Germany
- Prior art keywords
- dna
- receptive
- disposed
- emission beams
- emission
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012544 monitoring process Methods 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 abstract 3
- 230000005284 excitation Effects 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000003752 polymerase chain reaction Methods 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1811—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using electromagnetic induction heating
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6482—Sample cells, cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/024—Modular construction
- G01N2201/0245—Modular construction with insertable-removable part
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
- G01N2201/0628—Organic LED [OLED]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/063—Illuminating optical parts
- G01N2201/0635—Structured illumination, e.g. with grating
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/063—Illuminating optical parts
- G01N2201/0636—Reflectors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/068—Optics, miscellaneous
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8576598P | 1998-05-16 | 1998-05-16 | |
US9278498P | 1998-07-14 | 1998-07-14 | |
PCT/US1999/011088 WO1999060381A1 (en) | 1998-05-16 | 1999-05-17 | Instrument for monitoring polymerase chain reaction of dna |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69939259D1 true DE69939259D1 (de) | 2008-09-18 |
Family
ID=26773060
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69939259T Expired - Lifetime DE69939259D1 (de) | 1998-05-16 | 1999-05-17 | Gerät zur überwachung der polymerase-ketten reaktion von dna |
DE69940574T Expired - Lifetime DE69940574D1 (de) | 1998-05-16 | 1999-05-17 | Optisches Gerät insbesondere zur Überwachung von DNS-Polymerasekettenreaktionen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69940574T Expired - Lifetime DE69940574D1 (de) | 1998-05-16 | 1999-05-17 | Optisches Gerät insbesondere zur Überwachung von DNS-Polymerasekettenreaktionen |
Country Status (9)
Country | Link |
---|---|
US (1) | US9671342B2 (de) |
EP (4) | EP3093649B1 (de) |
JP (7) | JP2003524754A (de) |
CN (2) | CN1201016C (de) |
AT (2) | ATE403856T1 (de) |
AU (1) | AU759974B2 (de) |
CA (1) | CA2328609A1 (de) |
DE (2) | DE69939259D1 (de) |
WO (1) | WO1999060381A1 (de) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7560273B2 (en) * | 2002-07-23 | 2009-07-14 | Applied Biosystems, Llc | Slip cover for heated platen assembly |
US7498164B2 (en) | 1998-05-16 | 2009-03-03 | Applied Biosystems, Llc | Instrument for monitoring nucleic acid sequence amplification reaction |
JP2003524754A (ja) | 1998-05-16 | 2003-08-19 | ピーイー コーポレイション (エヌワイ) | Dnaのポリメラーゼ連鎖反応をモニタする装置 |
US6818437B1 (en) | 1998-05-16 | 2004-11-16 | Applera Corporation | Instrument for monitoring polymerase chain reaction of DNA |
US7423750B2 (en) | 2001-11-29 | 2008-09-09 | Applera Corporation | Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion |
US7410793B2 (en) | 1999-05-17 | 2008-08-12 | Applera Corporation | Optical instrument including excitation source |
US7387891B2 (en) | 1999-05-17 | 2008-06-17 | Applera Corporation | Optical instrument including excitation source |
US20050279949A1 (en) | 1999-05-17 | 2005-12-22 | Applera Corporation | Temperature control for light-emitting diode stabilization |
WO2001007896A1 (en) * | 1999-07-21 | 2001-02-01 | Tropix, Inc. | Luminescence detection workstation |
EP1617207A3 (de) * | 1999-07-21 | 2006-05-31 | Applera Corporation | Arbeitsplatz zur Lumineszenzdetektion |
PL359598A1 (en) * | 2000-05-09 | 2004-08-23 | Xy, Inc. | High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa |
US6563581B1 (en) | 2000-07-14 | 2003-05-13 | Applera Corporation | Scanning system and method for scanning a plurality of samples |
JP3741051B2 (ja) * | 2001-05-10 | 2006-02-01 | 横河電機株式会社 | バイオチップ読取装置 |
US6594010B2 (en) * | 2001-07-06 | 2003-07-15 | Praxair Technology, Inc. | Emission spectrometer having a charge coupled device detector |
US6867005B2 (en) * | 2001-10-24 | 2005-03-15 | Beckman Coulter, Inc. | Method and apparatus for increasing the dynamic range and accuracy of binding assays |
US7635588B2 (en) | 2001-11-29 | 2009-12-22 | Applied Biosystems, Llc | Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength |
DE10201463B4 (de) * | 2002-01-16 | 2005-07-21 | Clondiag Chip Technologies Gmbh | Reaktionsgefäß zur Durchführung von Array-Verfahren |
DE10204531A1 (de) * | 2002-02-01 | 2003-08-21 | Inst Chemo Biosensorik | Deckelelement |
US9157860B2 (en) | 2002-05-16 | 2015-10-13 | Applied Biosystems, Llc | Achromatic lens array |
US6982166B2 (en) | 2002-05-16 | 2006-01-03 | Applera Corporation | Lens assembly for biological testing |
EP1511991B1 (de) * | 2002-05-17 | 2015-05-06 | Life Technologies Corporation | Optisches instrument mit anregungsquelle |
ATE537438T1 (de) | 2002-05-17 | 2011-12-15 | Life Technologies Corp | Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge |
KR100794699B1 (ko) * | 2002-06-18 | 2008-01-14 | (주)바이오니아 | 핵산증폭반응 산물의 실시간 모니터링 장치 |
US7083974B2 (en) | 2002-07-12 | 2006-08-01 | Applera Corporation | Rotatable sample disk and method of loading a sample disk |
US7452712B2 (en) | 2002-07-30 | 2008-11-18 | Applied Biosystems Inc. | Sample block apparatus and method of maintaining a microcard on a sample block |
US7148043B2 (en) * | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
US7295316B2 (en) | 2004-01-14 | 2007-11-13 | Applera Corporation | Fluorescent detector with automatic changing filters |
DE602005007582D1 (de) * | 2004-01-14 | 2008-07-31 | Applera Corp | In biologischen proben |
ATE357653T1 (de) * | 2005-01-18 | 2007-04-15 | Hoffmann La Roche | Fluoreszenzabbildung mittels telezentrischer anregungs- und abbildungsoptiken |
ES2285578T3 (es) * | 2005-01-18 | 2007-11-16 | F. Hoffmann-La Roche Ag | Visualizacion de señales de fluorescencia utilizando telecentricidad. |
EP1681558B1 (de) * | 2005-01-18 | 2007-11-14 | Roche Diagnostics GmbH | Fluoreszenzabbildung mittels telezentrischer Optiken auf Anregungs- und Abbildungsseite |
WO2006078036A1 (ja) * | 2005-01-24 | 2006-07-27 | Olympus Corporation | 生化学検査装置および生化学検査方法 |
FI20055043A0 (fi) * | 2005-01-31 | 2005-01-31 | Wallac Oy | Sovitelma mikrotiterkaivojen kuvausjärjestelmässä |
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DE102005027555B3 (de) * | 2005-06-14 | 2006-10-05 | Eppendorf Ag | Thermocycler |
DE102005043834A1 (de) * | 2005-09-13 | 2007-03-22 | Eppendorf Ag | Vorrichtung zur Durchführung von Real-Time PCR-Reaktionen |
JP2007093249A (ja) * | 2005-09-27 | 2007-04-12 | Yokogawa Electric Corp | 光量計測装置および光量計測方法 |
JP4696959B2 (ja) * | 2006-02-22 | 2011-06-08 | アイシン精機株式会社 | 光学検出装置 |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
JP5415253B2 (ja) | 2006-03-24 | 2014-02-12 | ハンディラブ・インコーポレーテッド | 微小流体サンプルを処理するための一体化システム及びその使用方法 |
JP2008082922A (ja) * | 2006-09-28 | 2008-04-10 | Sanyo Electric Co Ltd | 撮影装置及び細胞観察装置 |
JP4842175B2 (ja) | 2007-03-07 | 2011-12-21 | 東京エレクトロン株式会社 | 温度測定装置及び温度測定方法 |
KR101089045B1 (ko) * | 2007-06-28 | 2011-12-02 | (주)바이오니아 | 핵산증폭반응 산물의 실시간 모니터링장치 |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
EP2108699B1 (de) | 2008-04-08 | 2014-06-25 | F.Hoffmann-La Roche Ag | Vorrichtung zur analytischen Verarbeitung und Detektion |
US20110057120A1 (en) * | 2008-06-05 | 2011-03-10 | Bohle Ag | Apparatus for determining the element occupancy on a surface by means of fluorescence |
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1999
- 1999-05-17 JP JP2000549942A patent/JP2003524754A/ja active Pending
- 1999-05-17 AT AT99924365T patent/ATE403856T1/de not_active IP Right Cessation
- 1999-05-17 EP EP16172036.2A patent/EP3093649B1/de not_active Expired - Lifetime
- 1999-05-17 WO PCT/US1999/011088 patent/WO1999060381A1/en active Application Filing
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- 1999-05-17 EP EP99924365A patent/EP1078245B1/de not_active Expired - Lifetime
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- 1999-05-17 EP EP08011345A patent/EP1978351B1/de not_active Revoked
- 1999-05-17 CA CA002328609A patent/CA2328609A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
EP1978351A3 (de) | 2008-10-15 |
EP1978351B1 (de) | 2011-11-30 |
WO1999060381A1 (en) | 1999-11-25 |
EP3093649B1 (de) | 2019-05-08 |
JP2013178254A (ja) | 2013-09-09 |
ATE425448T1 (de) | 2009-03-15 |
EP1078245B1 (de) | 2008-08-06 |
EP2315002A3 (de) | 2012-12-05 |
EP1078245A1 (de) | 2001-02-28 |
CN1201016C (zh) | 2005-05-11 |
JP2009002955A (ja) | 2009-01-08 |
EP3093649A2 (de) | 2016-11-16 |
ATE403856T1 (de) | 2008-08-15 |
JP5881226B2 (ja) | 2016-03-09 |
EP2315002A2 (de) | 2011-04-27 |
EP1978351A2 (de) | 2008-10-08 |
US20070238161A1 (en) | 2007-10-11 |
JP2011039071A (ja) | 2011-02-24 |
EP3093649A3 (de) | 2017-04-26 |
CN1664562A (zh) | 2005-09-07 |
JP2003524754A (ja) | 2003-08-19 |
JP2016195602A (ja) | 2016-11-24 |
JP2005274579A (ja) | 2005-10-06 |
AU759974B2 (en) | 2003-05-01 |
AU4088499A (en) | 1999-12-06 |
JP2015072285A (ja) | 2015-04-16 |
DE69940574D1 (de) | 2009-04-23 |
CA2328609A1 (en) | 1999-11-25 |
CN1309766A (zh) | 2001-08-22 |
US9671342B2 (en) | 2017-06-06 |
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