DE69931376D1 - Häm-oxygenase 1 zur hemmung der glatten muskelzellenmigration - Google Patents

Häm-oxygenase 1 zur hemmung der glatten muskelzellenmigration

Info

Publication number
DE69931376D1
DE69931376D1 DE69931376T DE69931376T DE69931376D1 DE 69931376 D1 DE69931376 D1 DE 69931376D1 DE 69931376 T DE69931376 T DE 69931376T DE 69931376 T DE69931376 T DE 69931376T DE 69931376 D1 DE69931376 D1 DE 69931376D1
Authority
DE
Germany
Prior art keywords
oxygenase
hem
smooth muscle
cell migration
muscle cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69931376T
Other languages
English (en)
Other versions
DE69931376T2 (de
Inventor
J Nabel
G Nabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Publication of DE69931376D1 publication Critical patent/DE69931376D1/de
Application granted granted Critical
Publication of DE69931376T2 publication Critical patent/DE69931376T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99003—Heme oxygenase (1.14.99.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
DE69931376T 1998-08-21 1999-08-21 Häm-oxygenase 1 zur hemmung der glatten muskelzellenmigration Expired - Fee Related DE69931376T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9770798P 1998-08-21 1998-08-21
US97707P 1998-08-21
PCT/US1999/019245 WO2000010613A2 (en) 1998-08-21 1999-08-21 Inhibition of smooth muscle cell migration by heme oxygenase 1

Publications (2)

Publication Number Publication Date
DE69931376D1 true DE69931376D1 (de) 2006-06-22
DE69931376T2 DE69931376T2 (de) 2007-04-19

Family

ID=22264750

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69931376T Expired - Fee Related DE69931376T2 (de) 1998-08-21 1999-08-21 Häm-oxygenase 1 zur hemmung der glatten muskelzellenmigration

Country Status (6)

Country Link
US (1) US6203991B1 (de)
EP (1) EP1109914B1 (de)
AU (1) AU5687799A (de)
CA (1) CA2343575C (de)
DE (1) DE69931376T2 (de)
WO (1) WO2000010613A2 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698531A (en) * 1989-03-31 1997-12-16 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US7238673B2 (en) * 1989-03-31 2007-07-03 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US8128963B2 (en) * 1996-09-27 2012-03-06 The Trustees Of Columbia University In The City Of New York Methods for treating ischemic disorders using carbon monoxide
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7678390B2 (en) * 1999-04-01 2010-03-16 Yale University Carbon monoxide as a biomarker and therapeutic agent
US7261881B1 (en) * 1999-05-20 2007-08-28 Yale University Modulation of angiogenesis and wound healing
PT1328213E (pt) 2000-10-16 2005-10-31 Conor Medsystems Inc Dispositivo medico expansivel para a administracao de um agente benefico
US20040073294A1 (en) 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20020192688A1 (en) * 2001-04-05 2002-12-19 Xiaoming Yang Imaging nucleic acid delivery
AU2002256388A1 (en) * 2001-04-30 2002-11-11 Cell Genesys, Inc. Viral-mediated delivery and in vivo expression of polynucleotides encoding anti-angiogenic proteins
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US20030022870A1 (en) * 2001-06-01 2003-01-30 Victor Dzau Methods of treating cardiac disorders
KR20040032115A (ko) * 2001-06-21 2004-04-14 베쓰 이스라엘 디코니스 메디칼 센터 인크 조직 및 장기 이식 결과의 개선 및 아폽토시스의 억제에사용되는 일산화탄소
US20030100889A1 (en) * 2001-07-05 2003-05-29 Nicolas Duverger Method of administration of a gene of interest to a vascular tissue
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP1476168A2 (de) 2002-02-04 2004-11-17 ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. Verwendung von co-freisetzenden molekülen zur behandlung von entzündlichen krankheiten
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EA200401070A1 (ru) * 2002-02-13 2005-02-24 Бет Изрейэл Диконисс Медикал Сентер, Инк. Способы лечения сосудистых заболеваний
CA2482260A1 (en) 2002-04-15 2003-10-30 Beth Israel Deaconess Medical Center Inc. Use of heme oxygenase-1 and products of heme degradation
UA86570C2 (ru) * 2002-04-15 2009-05-12 Юниверсити Оф Питтсбург Оф Дзе Коммонвелз Систем Оф Хайер Эдьюкейшн Способ лечения некротизирующего энтероколита
US7687079B2 (en) * 2002-04-15 2010-03-30 University of Pittsburgh of the Commonwealth System of Higher Education Yale University Methods of treating ileus
ES2372273T3 (es) 2002-05-17 2012-01-17 Yale University Métodos de tratamiento de la hepatitis.
UA87438C2 (ru) * 2002-06-05 2009-07-27 Йельский Университет Способы лечения или профилактики рака, способ проведения хирургической операции по удалению рака и применения монооксида углерода
MXPA04012863A (es) * 2002-06-21 2005-03-31 Univ Pittsburgh Uso farmaceutico de oxido nitrico, heme oxigenasa-1 y productos de degradacion de heme.
EA200500782A1 (ru) * 2002-11-07 2005-10-27 Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн Лечение геморрагического шока
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
EP2272544A1 (de) 2003-03-28 2011-01-12 Conor Medsystems, Inc. Implantierbare medizinische Vorrichtung enthaltend eine therapeutische Substanz in einem Konzentrationsgradient.
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US20070275874A1 (en) * 2004-09-03 2007-11-29 Yale University Use of Leptin in Wound Healing
EP1790350A1 (de) * 2005-11-24 2007-05-30 Interstitial Therapeutics Verwendung einer Keratinozytzusammensetzung für die Behandlung von Restenosis
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
CN101977632A (zh) * 2008-02-19 2011-02-16 塞拉东公司 用于增强病毒载体于心肌中的摄取的组合物
EP2699242B1 (de) 2011-04-19 2017-11-01 Alfama, Inc. Kohlenmonoxidfreisetzende moleküle und ihre verwendungen
JP6134710B2 (ja) 2011-07-21 2017-05-24 アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． 一酸化ルテニウム放出分子およびその使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066333A (en) 1994-09-22 2000-05-23 William Harvey Research Limited Pharmaceutical control of inflammation

Also Published As

Publication number Publication date
EP1109914A2 (de) 2001-06-27
WO2000010613A3 (en) 2000-07-06
CA2343575C (en) 2008-08-05
US6203991B1 (en) 2001-03-20
WO2000010613A2 (en) 2000-03-02
DE69931376T2 (de) 2007-04-19
EP1109914B1 (de) 2006-05-17
AU5687799A (en) 2000-03-14
CA2343575A1 (en) 2000-03-02

Similar Documents

Publication Publication Date Title
DE69931376D1 (de) Häm-oxygenase 1 zur hemmung der glatten muskelzellenmigration
GB2358570B (en) Modeling at more than one level of resolution
DE69910229D1 (de) Verbesserte wärmeübertragende antihaftbeschichtung
DE69908455D1 (de) Kuvertiervorrichtung
DE69832845D1 (de) Elektroplattierungsverfahren
DE59803086D1 (de) Elektrolyseapparat
ID23696A (id) Turunan siklobutilamina tersubstitusi
DE69926606D1 (de) Plazentaprotein 13
DK0915189T3 (da) Elektropletteringsapparat
ID28433A (id) Turunan propenil sefalosporin
ID24218A (id) Turunan piperidinilmetiloksazolidinon
NO20005551D0 (no) 2"-deoksyhygromycinderivater
DE69903567D1 (de) Kalziumsalze enthaltende elektrotauchlackbäder
KR960015283U (ko) 표면 저항 측정기
FR2766727B1 (fr) Exerciseur
DE69529157D1 (de) Zusammensetzungen enthaltend filmbildende schweisshemmende polymere
FI974544A0 (fi) Anordning i en med manoeverplats foersedd lastkran
NO996127D0 (no) 13-dihydro-3'-aziridino-antracykliner
DE29811122U1 (de) Depositeinrichtung
DE29713865U1 (de) Hantelstange
NO985028D0 (no) Plattformbro 98
IT1293816B1 (it) Apparecchiatura per elettrolisi
NO971798D0 (no) Nivåmåler
NO973474D0 (no) Nivåmåler
KR950026554U (ko) 미끄럼 방지 발닦이

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee