DE69930269D1 - Wasserlösslische prodrugs von gehinderten phenolen - Google Patents

Wasserlösslische prodrugs von gehinderten phenolen

Info

Publication number
DE69930269D1
DE69930269D1 DE69930269T DE69930269T DE69930269D1 DE 69930269 D1 DE69930269 D1 DE 69930269D1 DE 69930269 T DE69930269 T DE 69930269T DE 69930269 T DE69930269 T DE 69930269T DE 69930269 D1 DE69930269 D1 DE 69930269D1
Authority
DE
Germany
Prior art keywords
water
phenoles
disabled
soluble prodrugs
prodrugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69930269T
Other languages
English (en)
Other versions
DE69930269T2 (de
Inventor
J Stella
J Zygmunt
Gunda Georg
S Safadi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kansas
Original Assignee
University of Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kansas filed Critical University of Kansas
Application granted granted Critical
Publication of DE69930269D1 publication Critical patent/DE69930269D1/de
Publication of DE69930269T2 publication Critical patent/DE69930269T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69930269T 1998-08-07 1999-08-06 Wasserlösslische prodrugs von gehinderten phenolen Expired - Lifetime DE69930269T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US131385 1998-08-07
US09/131,385 US6204257B1 (en) 1998-08-07 1998-08-07 Water soluble prodrugs of hindered alcohols
PCT/US1999/017779 WO2000008033A1 (en) 1998-08-07 1999-08-06 Water soluble prodrugs of hindered alcohols or phenols

Publications (2)

Publication Number Publication Date
DE69930269D1 true DE69930269D1 (de) 2006-05-04
DE69930269T2 DE69930269T2 (de) 2006-12-07

Family

ID=22449234

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69930269T Expired - Lifetime DE69930269T2 (de) 1998-08-07 1999-08-06 Wasserlösslische prodrugs von gehinderten phenolen

Country Status (27)

Country Link
US (4) US6204257B1 (de)
EP (2) EP1683803A1 (de)
JP (1) JP4554081B2 (de)
KR (1) KR100662799B1 (de)
CN (2) CN1680402A (de)
AT (1) ATE319723T1 (de)
AU (1) AU769755B2 (de)
BR (1) BR9912853A (de)
CA (1) CA2339834C (de)
CY (1) CY1105043T1 (de)
CZ (1) CZ304020B6 (de)
DE (1) DE69930269T2 (de)
DK (1) DK1102776T3 (de)
ES (1) ES2268876T3 (de)
HK (1) HK1047939B (de)
HU (1) HU229401B1 (de)
IL (1) IL141316A (de)
MX (1) MXPA01001431A (de)
NO (1) NO330357B1 (de)
NZ (1) NZ509795A (de)
PL (1) PL198141B1 (de)
PT (1) PT1102776E (de)
RU (1) RU2235727C2 (de)
TR (1) TR200100772T2 (de)
UA (1) UA73479C2 (de)
WO (1) WO2000008033A1 (de)
ZA (1) ZA200101039B (de)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
IL141095A0 (en) * 1998-08-19 2002-02-10 Rtp Pharma Inc Injectable aqueous dispersions of propofol
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6362234B1 (en) * 2000-08-15 2002-03-26 Vyrex Corporation Water-soluble prodrugs of propofol for treatment of migrane
US6448401B1 (en) * 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
WO2002085928A2 (fr) * 2001-04-20 2002-10-31 Debiopharm S.A. Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation
WO2003026632A2 (en) * 2001-09-26 2003-04-03 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
KR100937162B1 (ko) * 2001-12-21 2010-01-15 에이자이 아이엔씨. 알콜 및 페놀의 수용성 포스포노옥시메틸 유도체를제조하는 방법
US20050042280A1 (en) * 2001-12-28 2005-02-24 Rogers Tracey L. Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
MXPA04009703A (es) * 2002-04-08 2004-12-13 Guilford Pharm Inc Composiciones farmaceuticas que contienen promedicamentos solubles en agua de propofol y metodoss para administrar los mismos.
ITRM20020306A1 (it) 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
ZA200504940B (en) * 2003-01-28 2006-09-27 Xenoport Inc Amino acid derived prodrugs of propofol, compositions and uses thereof
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
US7230003B2 (en) * 2003-09-09 2007-06-12 Xenoport, Inc. Aromatic prodrugs of propofol, compositions and uses thereof
CN1882548A (zh) * 2003-10-24 2006-12-20 奥斯佩克斯制药公司 2,6－二异丙基苯酚的pH敏感性前药
US7834043B2 (en) * 2003-12-11 2010-11-16 Abbott Laboratories HIV protease inhibiting compounds
CA2548216A1 (en) * 2003-12-17 2005-06-30 Mgi Gp, Inc. Methods of administering water-soluble prodrugs of propofol for extended sedation
JP5616569B2 (ja) 2004-04-15 2014-10-29 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 酵素阻害のための化合物
US8198270B2 (en) * 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
US7232818B2 (en) 2004-04-15 2007-06-19 Proteolix, Inc. Compounds for enzyme inhibition
AU2005243140A1 (en) * 2004-05-10 2005-11-24 Proteolix, Inc. Synthesis of amino acid keto-epoxides
ES2510840T3 (es) * 2004-05-10 2014-10-21 Onyx Therapeutics, Inc. Compuestos para la inhibición enzimática del proteosoma
JP5142714B2 (ja) 2004-07-06 2013-02-13 アボット・ラボラトリーズ Ｈｉｖプロテアーゼ阻害薬のプロドラッグ
EP1781596B1 (de) * 2004-07-12 2008-10-08 Xenoport, Inc. Von aminosäuren abgeleitete prodrugs von propofolzusammensetzungen und anwendungen davon
US7241807B2 (en) * 2004-07-12 2007-07-10 Xenoport, Inc. Prodrugs of propofol, compositions and uses thereof
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
WO2006027711A2 (en) * 2004-08-26 2006-03-16 Nicholas Piramal India Limited Prodrugs and codrugs containing bio- cleavable disulfide linkers
EP1791521A4 (de) * 2004-09-17 2009-10-21 Eisai Corp North America Verfahren zum verabreichen von wasserlöslichen prodrugs von propofol
ATE456552T1 (de) * 2004-12-23 2010-02-15 Xenoport Inc Von serinaminosäure abgeleitete prodrugs von propofol, zusammensetzungen, anwendungen und kristalline formen davon
WO2006133506A1 (en) 2005-06-17 2006-12-21 Vital Health Sciences Pty Ltd A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
US20090221532A1 (en) * 2005-07-12 2009-09-03 Mgi Gp, Inc. Methods Of Dosing Propofol Prodrugs For Inducing Mild To Moderate Levels Of Sedation
ATE449618T1 (de) 2005-08-18 2009-12-15 Zimmer Gmbh Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln
US20080234229A1 (en) * 2005-08-18 2008-09-25 Auspex Pharmaceuticals, Inc. Novel Therapeutic Agents for the Treatment of Cancer, Metabolic Diseases and Skin Disorders
US7589239B2 (en) * 2005-09-02 2009-09-15 Auspex Pharmaceuticals Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
CN101282979B (zh) * 2005-09-13 2011-09-21 卫材R&D管理有限公司 稳定性被改善的含有磷酸氯甲酯衍生物的组合物及其制备方法
HUE034863T2 (en) * 2005-11-09 2018-03-28 Onyx Therapeutics Inc Compound for inhibiting enzyme
NZ603303A (en) 2006-06-19 2014-05-30 Onyx Therapeutics Inc Peptide epoxyketones for proteasome inhibition
JP2010505826A (ja) * 2006-10-05 2010-02-25 エーザイ インコーポレイテッド プロポフォールの水溶性プロドラッグの水ベースの薬学的製剤
WO2008052044A2 (en) * 2006-10-26 2008-05-02 Xenoport, Inc. Use of derivatives of propofol for treating diseases associated with oxidative stress
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
AU2008236996B2 (en) 2007-04-10 2012-11-08 Zimmer, Inc. An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
MX2009012125A (es) 2007-05-09 2010-02-18 Pharmacofore Inc Compuestos terapeuticos.
CN101715437B (zh) 2007-05-09 2013-06-12 特色疗法股份有限公司 立体异构异丙酚治疗性化合物
US20090005444A1 (en) * 2007-06-21 2009-01-01 Xenoport, Inc. Use of propofol prodrugs for treating alcohol withdrawal, central pain, anxiety or pruritus
FI20070574A0 (fi) * 2007-07-30 2007-07-30 Kuopion Yliopisto Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke
CN104505594B (zh) * 2007-09-13 2018-07-24 天文电子学爱罗莎特股份有限公司 有宽带天线的通信系统
US8427384B2 (en) 2007-09-13 2013-04-23 Aerosat Corporation Communication system with broadband antenna
US20090076141A1 (en) * 2007-09-14 2009-03-19 Xenoport, Inc. Use of Propofol Prodrugs for Treating Neuropathic Pain
US20090075947A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched fospropofol
WO2009045497A1 (en) 2007-10-04 2009-04-09 Proteolix, Inc. Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
US20090098209A1 (en) * 2007-10-15 2009-04-16 University Of Kansas Pharmaceutical compositions containing water-soluble derivatives of propofol and methods of administering same via pulmonary administration
WO2009120162A1 (ru) * 2008-03-25 2009-10-01 Zhukovskij Oleg Igorevich Субстанция "ua' orion"
EP2291348A4 (de) * 2008-05-20 2013-05-15 Neurogesx Inc Wasserlösliche acetaminophenanaloga
KR101677126B1 (ko) * 2008-05-20 2016-11-22 노이로제스엑스, 인코포레이티드 탄산염 프로드러그 및 그것의 사용 방법
WO2010047737A2 (en) 2008-09-02 2010-04-29 Micurx Pharmaceuticals, Inc. Antimicrobial indoline compounds for treatment of bacterial infections
EA035100B1 (ru) 2008-10-21 2020-04-28 Оникс Терапьютикс, Инк. Комбинированная терапия с применением пептид эпоксикетонов
CN101798302B (zh) 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
CN101845057B (zh) * 2009-03-27 2013-10-23 四川大学 取代苯酚的甲缩醛磷酸盐麻醉镇静药用化合物及制备方法
GB0905834D0 (en) 2009-04-03 2009-05-20 Seps Pharma Nv Phosphonyl-containing phenolic derivatives useful as medicaments
CA2760953C (en) * 2009-05-07 2017-05-30 Regents Of The University Of Minnesota Triptolide prodrugs
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
CN101648973B (zh) * 2009-09-03 2012-05-30 漆又毛 水溶性紫杉烷及制备方法
WO2011060179A1 (en) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Use of peptide epoxyketones for metastasis suppression
EP2531047A4 (de) 2010-02-05 2014-03-19 Phosphagenics Ltd Träger mit einem nichtneutralisierten tocopherylphosphat
CN102153607B (zh) * 2010-02-11 2015-07-15 湖南方盛华美医药科技有限公司 水溶性喜树碱衍生物及包含其的药物组合物
CA2791651C (en) 2010-03-01 2019-08-20 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
EP2552486B1 (de) 2010-03-30 2020-08-12 Phosphagenics Limited Pflaster für transdermale verabreichung
AU2011245630B2 (en) 2010-04-07 2014-07-03 Onyx Therapeutics, Inc. Crystalline peptide epoxyketone immunoproteasome inhibitor
US8399535B2 (en) * 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
US20120065170A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
DK2646035T3 (en) * 2010-12-02 2016-05-30 Univ Kansas PRO-DRUGS OF 6-CYCLOHEXYL-1-HYDROXY-4-METHYLPYRIDINE-2 (1H) -ON AND DERIVATIVES THEREOF
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
ITMI20110580A1 (it) * 2011-04-08 2012-10-09 Chemelectiva S R L Iintermedi utili per la preparazione di fospropofol e processo per la loro preparazione
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol
AU2012312136B2 (en) 2011-09-22 2017-06-29 Acorda Therapeutics, Inc. Acetaminophen conjugates, compositions and methods of use thereof
CN102516258B (zh) * 2011-11-11 2014-06-25 正大天晴药业集团股份有限公司 水溶性维生素e衍生物修饰的脂溶性抗癌药物化合物和制剂、该化合物的制备方法及应用
CN102382133B (zh) * 2011-12-02 2016-03-23 陕西合成药业股份有限公司 一种磷丙泊酚钠的制备及纯化方法
UY34897A (es) 2012-07-09 2014-01-31 Onyx Therapeutics Inc Profarmacos de inhibidores peptidicos de expoxi cetona proteasa
US9580459B2 (en) * 2013-04-26 2017-02-28 Metselex, Inc. Water-soluble ursodeoxycholic acid prodrugs
EP3052562B1 (de) 2013-10-01 2017-11-08 Zimmer, Inc. Polymerzusammensetzungen, enthaltend ein oder mehrere geschützte antioxidantien
EP3099304A4 (de) 2014-01-31 2018-01-10 Mayo Foundation for Medical Education and Research Neuartige therapeutika zur behandlung von glaukom
CA2939098A1 (en) 2014-02-21 2015-08-27 Micurx Pharmaceuticals, Inc. Water-soluble o-carbonyl phosphoramidate prodrugs for therapeutic administration
EP3116941A1 (de) 2014-03-12 2017-01-18 Zimmer, Inc. Schmelzstabilisiertes polyethylen mit ultrahohem molekulargewicht und verfahren zu seiner herstellung
SI3209302T1 (sl) 2014-10-21 2019-06-28 Abb Vie Inc. Predzdravila karbidope in L-dope in njihova uporaba za zdravljenje parkinsonove bolezni
CN107207741B (zh) 2014-12-03 2021-05-11 捷迈有限公司 注入抗氧剂的超高分子量聚乙烯
CN106674268A (zh) * 2015-11-11 2017-05-17 陕西合成药业股份有限公司 一种磷丙泊酚钠三水合物及晶型及其制备方法和用途
CN106674269A (zh) * 2015-11-11 2017-05-17 陕西合成药业股份有限公司 一种磷丙泊酚钠四水合物及晶型及其制备方法和用途
CN106674270A (zh) * 2015-11-11 2017-05-17 陕西合成药业股份有限公司 一种磷丙泊酚钠无水合物及晶型及其制备方法和用途
WO2017096427A1 (en) 2015-12-09 2017-06-15 Phosphagenics Limited Pharmaceutical formulation
US10851123B2 (en) * 2016-02-23 2020-12-01 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
WO2017184871A1 (en) * 2016-04-20 2017-10-26 Abbvie Inc. Carbidopa and l-dopa prodrugs and methods of use
US11331271B2 (en) * 2016-05-27 2022-05-17 The Johns Hopkins University Buccal, sublingual and intranasal delivery of fospropofol
WO2018017518A2 (en) 2016-07-21 2018-01-25 Astronics Aerosat Corporation Multi-channel communications antenna
CN110662733A (zh) 2016-12-21 2020-01-07 埃维科生物技术有限公司 方法
US10992052B2 (en) 2017-08-28 2021-04-27 Astronics Aerosat Corporation Dielectric lens for antenna system
US10174138B1 (en) * 2018-01-25 2019-01-08 University Of Massachusetts Method for forming highly reactive olefin functional polymers
CN109456360B (zh) * 2018-12-17 2021-05-14 河南中医药大学 一种磷丙泊酚钠的制备方法
WO2020156189A1 (zh) * 2019-01-30 2020-08-06 四川科伦博泰生物医药股份有限公司 喜树碱衍生物及其水溶性前药、包含其的药物组合物及其制备方法和用途
US11628178B2 (en) 2019-03-26 2023-04-18 Epalex Corporation Fospropofol methods and compositions
US11478490B1 (en) 2021-03-30 2022-10-25 Epalex Corporation Fospropofol formulations
US11547714B2 (en) 2020-02-05 2023-01-10 Epalex Corporation Fospropofol salts, methods and compositions
US11439653B1 (en) 2021-03-30 2022-09-13 Epalex Corporation Fospropofol formulations
WO2021228150A1 (zh) * 2020-05-13 2021-11-18 成都百裕制药股份有限公司 大麻素衍生物及其制备方法和在医药上的应用
EP4319820A1 (de) 2021-04-10 2024-02-14 Profoundbio Us Co. Folr1-bindende wirkstoffe, konjugate davon und verfahren zur verwendung davon
CA3216459A1 (en) 2021-04-23 2022-10-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2829151A (en) 1952-11-03 1958-04-01 Dow Chemical Co Chlorotoloxy-ethyl phosphates
US3271314A (en) 1958-12-04 1966-09-06 Ethyl Corp 2, 6-diisopropylphenol
GB1146173A (en) 1966-06-18 1969-03-19 Geigy Uk Ltd Production of triaryl phosphates
US3723578A (en) 1970-10-13 1973-03-27 Gaf Corp Phosphate esters of ethers of thiol substituted phenols
US4171272A (en) 1977-12-02 1979-10-16 Fmc Corporation Turbine lubricant
FR2601259B1 (fr) 1986-07-11 1990-06-22 Rhone Poulenc Chimie Nouvelles compositions tensio-actives a base d'esters phosphoriques leur procede de preparation et leur application a la formulation de matieres actives.
US5364858A (en) 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5106742A (en) 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4894456A (en) 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5244903A (en) 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5122526A (en) 1987-03-31 1992-06-16 Research Triangle Institute Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US5053512A (en) 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5180722A (en) 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5049668A (en) 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5122606A (en) 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
MY103951A (en) 1988-01-12 1993-10-30 Kao Corp Detergent composition
CA2014539C (en) 1989-04-17 2000-07-25 Shinichiro Umeda Water borne metallic coating composition
US5091211A (en) 1989-08-17 1992-02-25 Lord Corporation Coating method utilizing phosphoric acid esters
JPH03209414A (ja) 1990-01-12 1991-09-12 Nikon Corp 焦点調節装置
AU660918B2 (en) 1990-10-17 1995-07-13 Arysta Lifescience Corporation Method and composition for enhancing uptake and transport of bioactive agents in plants
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
MX9308012A (es) 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
US5731356A (en) * 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
US5786344A (en) * 1994-07-05 1998-07-28 Arch Development Corporation Camptothecin drug combinations and methods with reduced side effects
US5646159A (en) 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
IT1270093B (it) 1994-09-28 1997-04-28 Zambon Spa Processo per la purificazione di 2,6-diisopropilfenolo
TW354293B (en) 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
US5804682A (en) 1995-11-29 1998-09-08 Henkel Corporation Aqueous dispersions of polyamides
US5637625A (en) 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
US5746973A (en) 1996-07-10 1998-05-05 Naraghi; Ali Method for reducing odorant depletion
CA2318817A1 (en) * 1998-01-29 1999-08-05 Bristol-Myers Squibb Company Phosphate derivatives of diaryl 1,3,4-oxadiazolone
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols

Also Published As

Publication number Publication date
NO20010659L (no) 2001-04-06
TR200100772T2 (tr) 2001-12-21
HU229401B1 (en) 2013-12-30
HK1047939A1 (en) 2003-03-14
PT1102776E (pt) 2007-02-28
US20030176324A1 (en) 2003-09-18
IL141316A0 (en) 2002-03-10
MXPA01001431A (es) 2002-11-29
CZ304020B6 (cs) 2013-08-28
EP1683803A1 (de) 2006-07-26
PL198141B1 (pl) 2008-05-30
DE69930269T2 (de) 2006-12-07
CA2339834A1 (en) 2000-02-17
ATE319723T1 (de) 2006-03-15
US6872838B2 (en) 2005-03-29
IL141316A (en) 2004-06-20
DK1102776T3 (da) 2006-07-10
NZ509795A (en) 2003-10-31
ZA200101039B (en) 2002-02-05
CN1198834C (zh) 2005-04-27
CN1357000A (zh) 2002-07-03
US20050090431A1 (en) 2005-04-28
CN1680402A (zh) 2005-10-12
JP4554081B2 (ja) 2010-09-29
CY1105043T1 (el) 2010-03-03
JP2002522443A (ja) 2002-07-23
KR100662799B1 (ko) 2007-01-02
EP1102776A1 (de) 2001-05-30
WO2000008033A1 (en) 2000-02-17
EP1102776B1 (de) 2006-03-08
ES2268876T3 (es) 2007-03-16
RU2235727C2 (ru) 2004-09-10
UA73479C2 (uk) 2005-08-15
US6451776B2 (en) 2002-09-17
HUP0200317A2 (en) 2002-06-29
US20010025035A1 (en) 2001-09-27
AU5339499A (en) 2000-02-28
NO330357B1 (no) 2011-04-04
CA2339834C (en) 2011-01-25
PL347211A1 (en) 2002-03-25
BR9912853A (pt) 2001-10-30
US6204257B1 (en) 2001-03-20
HUP0200317A3 (en) 2004-07-28
KR20010079627A (ko) 2001-08-22
HK1047939B (zh) 2005-11-18
CZ2001479A3 (cs) 2001-09-12
NO20010659D0 (no) 2001-02-07
AU769755B2 (en) 2004-02-05
US7244718B2 (en) 2007-07-17

Similar Documents

Publication Publication Date Title
DE69930269D1 (de) Wasserlösslische prodrugs von gehinderten phenolen
DK0486948T3 (da) Forbindelser, der hæmmer retrovirale proteaser
ES2195970T3 (es) L-ribavirina y usos de la misma.
IL124593A0 (en) Substituted aryl or heteroarylamides having retinoid-like biological activity
FI931708A0 (fi) Herbicida substituerade aryl-haloalkylpyrazoler
ATE199906T1 (de) Phosphonat-nukleotid ester-derivate
FI903331A0 (fi) Substituerade kinazolinoner, vilka aer anvaendbara som angiotensin-ii-antagonister.
DK1200418T3 (da) Nematodicide trifluorbutener
BR9502522A (pt) Composiçao concentrada em suspensao
DE69017969T2 (de) 2-Cyclohexylpropionsäure oder Derivate davon enthaltende Riechstoffzusammensetzung.
SE9604582D0 (sv) Novel compounds
IT8919735A0 (it) Procedimento per la riduzione del cod da reflui industriali o urbani.
ES2003063A4 (es) Derivados de pirrolidin-2-ona, que tengan actividad nootropica.
FI923751A (fi) Hexahydrobenso/f/kinolinoner
FR2661809B3 (fr) Diffuseur personnel de parfum ou de desodorisant.
ATE238791T1 (de) Verwendung von 2-methyl-thiazolidin-2,4- dicarbonsäure als mukolytikum
ES2089281T3 (es) Nuevos derivados de 2-mercaptometileno-tetrahidronaftaleno y 2-carboxamida indanos como inhibidores de la encefalinasa.
PT100026A (pt) Poliamina-fenois com accao radioprotectora
DK0673913T3 (da) Calcium-alkalimetalcitratforbindelser samt deres anvendelse som lægemidler
ES2117992T3 (es) Derivados de pirazina.
IT222972Z2 (it) Impianto perfezionato per il trattamento di aria inquinata o simili.
UA10153A (uk) beta-[beta'-(2,4-ДІ-ТРЕТ-АМІЛФЕНОКСИ)-ЕТОКСИ] ЕТИЛХЛОРИД ЯК НАПІВПРОДУКТ ДЛЯ ОДЕРЖАННЯ РЕЧОВИН, ЯКІ МАЮТЬ АНТИМІКРОБНІ ВЛАСТИВОСТІ

Legal Events

Date Code Title Description
8364 No opposition during term of opposition