DE69930155D1 - Spray verabreichung von zellen - Google Patents

Spray verabreichung von zellen

Info

Publication number
DE69930155D1
DE69930155D1 DE69930155T DE69930155T DE69930155D1 DE 69930155 D1 DE69930155 D1 DE 69930155D1 DE 69930155 T DE69930155 T DE 69930155T DE 69930155 T DE69930155 T DE 69930155T DE 69930155 D1 DE69930155 D1 DE 69930155D1
Authority
DE
Germany
Prior art keywords
cells
fibrin
target surface
related protein
spray administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69930155T
Other languages
English (en)
Other versions
DE69930155T2 (de
Inventor
M Marshall
Ian Grant
A Cederholm-Williams
Robin Paul Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VIVOLUTION A/S, BIRKEROD, DK
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DE69930155D1 publication Critical patent/DE69930155D1/de
Application granted granted Critical
Publication of DE69930155T2 publication Critical patent/DE69930155T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/56—Fibrin; Thrombin
DE69930155T 1998-12-02 1999-12-02 Spray verabreichung von zellen Expired - Lifetime DE69930155T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11061498P 1998-12-02 1998-12-02
US110614P 1998-12-02
US15540399P 1999-09-22 1999-09-22
US155403P 1999-09-22
PCT/US1999/028524 WO2000032207A1 (en) 1998-12-02 1999-12-02 Spray delivery of cells

Publications (2)

Publication Number Publication Date
DE69930155D1 true DE69930155D1 (de) 2006-04-27
DE69930155T2 DE69930155T2 (de) 2006-11-23

Family

ID=26808226

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69930155T Expired - Lifetime DE69930155T2 (de) 1998-12-02 1999-12-02 Spray verabreichung von zellen

Country Status (12)

Country Link
US (1) US6479052B1 (de)
EP (1) EP1143983B1 (de)
JP (1) JP2002531176A (de)
AT (1) ATE318608T1 (de)
AU (1) AU764347B2 (de)
CA (1) CA2352810A1 (de)
DE (1) DE69930155T2 (de)
DK (1) DK1143983T3 (de)
ES (1) ES2257877T3 (de)
NO (1) NO20012695L (de)
NZ (1) NZ528340A (de)
WO (1) WO2000032207A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10025609A1 (de) * 2000-05-24 2001-12-13 Univ Ludwigs Albert Transfektionssystem
US7144729B2 (en) * 2000-09-01 2006-12-05 Dfb Pharmaceuticals, Inc. Methods and compositions for tissue regeneration
AUPR298901A0 (en) 2001-02-07 2001-03-08 McComb Foundation, Inc., The Cell suspension preparation technique and device
PT1357922E (pt) * 2001-02-07 2011-09-01 Mccomb Foundation Inc Técnica de preparação e uso de suspensão celular
DE10116362A1 (de) * 2001-04-02 2002-10-10 Biotissue Technologies Ag Zwei-Komponenten Zusammensetzungen zur in situ Herstellung v. Fibroblasten und Keratinozyten umfassenden Zelltransplantaten
DE10204405A1 (de) * 2002-02-04 2003-08-21 Surface Care Gmbh Plasmagel
US7588564B2 (en) * 2002-07-03 2009-09-15 Pharmaco Kinesis Corporation Apparatus for piezoelectric layer-wise pump and valve for use in local administration of biological response modifiers and therapeutic agents
US7641898B2 (en) * 2003-03-21 2010-01-05 Materials Evolution And Development Usa, Inc. Keratinocyte-fibrocyte concomitant grafting for wound healing
US20040193284A1 (en) * 2003-03-25 2004-09-30 Taheri Syde A. Myometrium as a source for cardiomyoplasty
US7766900B2 (en) * 2005-02-21 2010-08-03 Biomet Manufacturing Corp. Method and apparatus for application of a fluid
US7833522B2 (en) 2005-08-05 2010-11-16 Dixon David M Apparatus and method to treat a wound area
DE102007040252A1 (de) 2006-09-11 2008-06-12 Gerlach, Jörg, Prof. Dr. Sprühapparat für Zellen und Methode zur Anwendung gesprühter Zellen
WO2009100219A1 (en) * 2008-02-05 2009-08-13 University Of Virginia Patent Foundation Spraying device and related method for cell aggregates and cell aggregate suspension thereof
US8518272B2 (en) 2008-04-04 2013-08-27 Biomet Biologics, Llc Sterile blood separating system
CN102533652B (zh) * 2010-12-11 2014-01-15 清华大学 神经移植体的制备方法
DE102011100450B8 (de) 2011-04-27 2013-10-17 Jörg Gerlach Apparat zum Sprühen von Zellen, Herstellung des Apparates, Methode zum Sprühen mit dem Apparat und eine Zellsuspension gesprüht mit dem Apparat
KR101335176B1 (ko) * 2011-12-12 2013-11-29 테고사이언스 (주) 상처 치유용 드레싱재제
DE102011122227A1 (de) 2011-12-23 2013-06-27 Medizinische Hochschule Hannover Verfahren und Vorrichtung zur Herstellung eines bioartifiziellen Gewebekonstrukts
EP2981333A1 (de) * 2013-03-07 2016-02-10 Caladrius Biosciences, Inc. Stammzellzusammensetzungen und verfahren zur wundheilung damit
AU2013205148B2 (en) 2013-03-14 2014-10-30 AVITA Medical Americas, LLC Systems and methods for tissue processing and preparation of cell suspension therefrom
WO2014143981A1 (en) 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Deposition and imaging of particles on planar substrates
MX342233B (es) * 2014-02-04 2016-08-24 Alvaro Galue Eduardo Proceso de obtencion de un compuesto de aspersion celular de fibroblastos y queratinocitos humanos en solucion y su uso como agente regenerativo de lesiones cutáneas.
EP3468722B1 (de) * 2016-06-14 2022-02-09 RenovaCare Sciences Corp. Modulare vorrichtung für zellsprühen

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0341007B1 (de) * 1988-05-02 1994-09-14 Project Hear Chirurgisches Klebstoffmaterial
FR2639958B1 (fr) * 1988-12-06 1992-08-21 Lille Transfusion Sanguine Support biologique pour cultures cellulaires constitue de proteines plasmatiques coagulees par la thrombine, son utilisation pour la culture des keratinocytes, leur recuperation et leur transport a des fins d'utilisation therapeutique
US5376118A (en) * 1989-05-10 1994-12-27 United States Surgical Corporation Support material for cell impregnation
EP0402718B1 (de) * 1989-06-03 1994-11-02 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Kontrolle der Zellanordnung
FR2663226B1 (fr) * 1990-06-15 1994-11-18 Fondation Nale Transfusion San Colle biologique fluide.
DK83092D0 (da) 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
CN1091315A (zh) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
CA2188647A1 (en) * 1994-05-02 1995-11-09 Stewart Anthony Cederholm-Williams Recombinant fibrin chains, fibrin and fibrin-homologs
US5733545A (en) * 1995-03-03 1998-03-31 Quantic Biomedical Partners Platelet glue wound sealant
JP2002514948A (ja) * 1996-02-20 2002-05-21 コーヒージョン・コーポレーション 組織シーラント組成物とその使用方法
AU3990197A (en) * 1996-10-04 1998-04-09 Metropolitan Health Service Board Method of engraftment of cultured cells
NZ335751A (en) * 1996-11-15 2001-01-26 Bristol Myers Squibb Co Devices and methods for applying a mixture of two or more liquid components to form a biomaterial
JP3333108B2 (ja) * 1997-04-08 2002-10-07 学校法人東海大学 上皮性組織移植片およびその製造方法

Also Published As

Publication number Publication date
CA2352810A1 (en) 2000-06-08
WO2000032207A1 (en) 2000-06-08
EP1143983B1 (de) 2006-03-01
AU1840200A (en) 2000-06-19
EP1143983A4 (de) 2003-05-28
NO20012695D0 (no) 2001-05-31
AU764347B2 (en) 2003-08-14
NO20012695L (no) 2001-07-03
US6479052B1 (en) 2002-11-12
DK1143983T3 (da) 2006-04-10
ATE318608T1 (de) 2006-03-15
EP1143983A1 (de) 2001-10-17
DE69930155T2 (de) 2006-11-23
ES2257877T3 (es) 2006-08-01
NZ528340A (en) 2005-07-29
JP2002531176A (ja) 2002-09-24

Similar Documents

Publication Publication Date Title
DE69930155D1 (de) Spray verabreichung von zellen
CA2220927A1 (en) Tissue adhesive suitable for spray application
DE69815843T2 (de) Schnellbindende latexbeschichtungen und zubereitungen
BR0006172A (pt) Composições adesivas de polìmero de propileno adequadas para revestimento de substratos
ES2194869T3 (es) Composicion adhesiva biologica y uso de la misma.
ATE456372T1 (de) Haftklebende n,o-carboxy methylchitosan beschichtungen, die die befestigung von zellen und proteinen mit den sustraten hemmen.
DE69933775D1 (de) Sprühverband und wirkstoffabgabesystem
BR9808668A (pt) Suspensão aquosa de microcápsulas compreendendo um material biologicamente ativo, e, processos para preparação de uma suspensão aquosa de microcápsulas aderentes e para aplicação de microcápsulas em um substrato pretendido
WO2002058750A3 (en) A suspension comprising fibrinogen, thrombin and alcohol and a method of coating a carrier with the same
BR0014904A (pt) Método de aperfeiçoar uma ligação entre uma superfìcie polimérica e um revestimento ou adesivo
AU5061098A (en) Biocompatible compositions
WO1999015715A3 (en) Coated products
DK570484A (da) Fremgangsmaade til forbedring af haeftningen af klaebemiddellag
AU2001243367A1 (en) Electrodepositable coating compositions including ungelled reaction products of epoxy functional polyesters and amines, coated substrates and methods of electrocoating using the same
WO1998036782A3 (de) Knochenersatzmaterial mit einer oberflächenbelegung mit peptiden mit rgd-aminosäuresequenz
AU4235497A (en) Combinatorial method of forming cascade polymer surfaces
BR0009804A (pt) Peptìdeos moduladores de adesão e seus usos
BR9811078A (pt) Composição de revestimento, processo de revestimento de um substrato, e, substrato revistido
BR9815177B1 (pt) mÉtodo para tratamento de uma superfÍcie pintada e composiÇço de prÉ-revestimento.
EP0905231A3 (de) Verfahren zür verbesserung der Stabilität und/oder Haltbarkeit von verschiedenen Substräten
NO990162L (no) Bioaktiv og hydrofil belegning av polymere substrater
MY132816A (en) Reactive silicone/ alkylenimine barrier laminating adhesives and applications thereof
AU2002358381A1 (en) Method and kit providing bioadhesive binding or coating with polyphenolic mussel proteins
BR0016020A (pt) Aplicador e processo papa revestimento de materiais de fibras
BR0011187A (pt) Composição, artigo e processo de revestimento

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: VIVOLUTION A/S, BIRKEROD, DK