DE69929796D1 - Evolution ganzer zellen und organismen durch rekursive sequenz-rekombination - Google Patents
Evolution ganzer zellen und organismen durch rekursive sequenz-rekombinationInfo
- Publication number
- DE69929796D1 DE69929796D1 DE69929796T DE69929796T DE69929796D1 DE 69929796 D1 DE69929796 D1 DE 69929796D1 DE 69929796 T DE69929796 T DE 69929796T DE 69929796 T DE69929796 T DE 69929796T DE 69929796 D1 DE69929796 D1 DE 69929796D1
- Authority
- DE
- Germany
- Prior art keywords
- evolution
- organisms
- whole cells
- sequence recombination
- recursive sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US116188 | 1993-09-03 | ||
US09/116,188 US6326204B1 (en) | 1997-01-17 | 1998-07-15 | Evolution of whole cells and organisms by recursive sequence recombination |
PCT/US1999/015972 WO2000004190A1 (en) | 1998-07-15 | 1999-07-15 | Evolution of whole cells and organisms by recursive sequence recombination |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69929796D1 true DE69929796D1 (de) | 2006-04-20 |
DE69929796T2 DE69929796T2 (de) | 2006-10-12 |
Family
ID=22365803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69929796T Expired - Lifetime DE69929796T2 (de) | 1998-07-15 | 1999-07-15 | Evolution ganzer zellen und organismen durch rekursive sequenz-rekombination |
Country Status (11)
Country | Link |
---|---|
US (6) | US6326204B1 (de) |
EP (2) | EP1108058B1 (de) |
JP (2) | JP4674329B2 (de) |
KR (1) | KR100647112B1 (de) |
AT (1) | ATE317453T1 (de) |
AU (1) | AU771511B2 (de) |
CA (2) | CA2720311A1 (de) |
DE (1) | DE69929796T2 (de) |
ES (1) | ES2257866T3 (de) |
IL (1) | IL140121A0 (de) |
WO (1) | WO2000004190A1 (de) |
Families Citing this family (231)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6335160B1 (en) * | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US7148054B2 (en) * | 1997-01-17 | 2006-12-12 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
WO1999021979A1 (en) | 1997-10-28 | 1999-05-06 | Maxygen, Inc. | Human papillomavirus vectors |
EP1690868A1 (de) * | 1997-10-31 | 2006-08-16 | Maxygen, Inc. | Modifizierung des Virustropismus und des Wirtspektrums durch virale Genomdurchmischung |
US6146894A (en) * | 1998-04-14 | 2000-11-14 | The Johns Hopkins University | Method for generating hypermutable organisms |
US6902918B1 (en) | 1998-05-21 | 2005-06-07 | California Institute Of Technology | Oxygenase enzymes and screening method |
US7153655B2 (en) | 1998-06-16 | 2006-12-26 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence |
AU4441699A (en) | 1998-06-17 | 2000-01-05 | Maxygen, Inc. | Method for producing polynucleotides with desired properties |
US20030092023A1 (en) * | 1998-08-12 | 2003-05-15 | Daniel Dupret | Method of shuffling polynucleotides using templates |
US20040023213A1 (en) * | 1998-08-12 | 2004-02-05 | Pangene Corporation | Domain specific gene evolution |
WO2000009727A2 (en) * | 1998-08-12 | 2000-02-24 | Maxygen, Inc. | Dna shuffling to produce herbicide selective crops |
US6991922B2 (en) * | 1998-08-12 | 2006-01-31 | Proteus S.A. | Process for in vitro creation of recombinant polynucleotide sequences by oriented ligation |
US20060242731A1 (en) * | 1998-08-12 | 2006-10-26 | Venkiteswaran Subramanian | DNA shuffling to produce herbicide selective crops |
US20040191772A1 (en) * | 1998-08-12 | 2004-09-30 | Dupret Daniel Marc | Method of shuffling polynucleotides using templates |
US6951719B1 (en) * | 1999-08-11 | 2005-10-04 | Proteus S.A. | Process for obtaining recombined nucleotide sequences in vitro, libraries of sequences and sequences thus obtained |
US20030104417A1 (en) * | 1998-08-12 | 2003-06-05 | Proteus S.A. | Template-mediated, ligation-oriented method of nonrandomly shuffling polynucleotides |
US6299850B1 (en) * | 1999-03-16 | 2001-10-09 | The United States Of America As Represented By The Department Of Energy | Carbon activation process for increased surface accessibility in electrochemical capacitors |
US7270969B2 (en) * | 1999-05-05 | 2007-09-18 | Phylogica Limited | Methods of constructing and screening diverse expression libraries |
US7033781B1 (en) | 1999-09-29 | 2006-04-25 | Diversa Corporation | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating |
EP1268765B1 (de) * | 2000-02-11 | 2008-08-13 | The Johns Hopkins University | Methode zur herstellung hypermutierender bakterien |
CA2400664C (en) * | 2000-02-18 | 2011-03-01 | Nicholas C. Nicolaides | A method for generating hypermutable plants |
EP1259628B1 (de) * | 2000-02-23 | 2007-01-17 | The Johns Hopkins University | Verfahren zur erzeugung von schnell mutierender hefe |
WO2001088192A2 (en) | 2000-05-12 | 2001-11-22 | The Johns Hopkins University | A method for generating hypermutable organisms |
US7115403B1 (en) | 2000-05-16 | 2006-10-03 | The California Institute Of Technology | Directed evolution of galactose oxidase enzymes |
EP1294869A2 (de) * | 2000-06-14 | 2003-03-26 | Diversa Corporation | Manipulation von ganzen zellen durch mutation eines grossteils des stargenoms, kombination der mutationen und wahlweises wiederholen |
WO2002004629A2 (en) * | 2000-07-07 | 2002-01-17 | Maxygen, Inc. | Molecular breeding of transposable elements |
US7435562B2 (en) | 2000-07-21 | 2008-10-14 | Modular Genetics, Inc. | Modular vector systems |
DE60134752D1 (de) * | 2000-08-11 | 2008-08-21 | Genencor Int | Transformation von bacillus, transformanten und mutanten-bibliotheken |
US6991786B1 (en) * | 2000-08-30 | 2006-01-31 | Wisconsin Alumni Research Foundation | Anti-microbial biotherapeutic agents: alternatives to conventional pharmaceutical antibiotics |
AU2001291057A1 (en) * | 2000-09-18 | 2002-04-02 | Pioneer Hi-Bred International, Inc. | Rice MLH1 ortholog and uses thereof |
US7083945B1 (en) * | 2000-10-27 | 2006-08-01 | The Board Of Regents Of The University Of Texas System | Isolation of binding proteins with high affinity to ligands |
US7235643B2 (en) * | 2000-11-07 | 2007-06-26 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with high affinity |
US6808894B1 (en) | 2000-11-07 | 2004-10-26 | Morphotek, Inc. | Methods for generating genetically altered antibody producing cell lines with improved antibody characteristics |
US7223598B2 (en) * | 2000-11-07 | 2007-05-29 | Morphotek, Inc. | Methods for isolating novel antimicrobial agents from hypermutable mammalian cells |
US6576468B1 (en) | 2000-11-07 | 2003-06-10 | Morphotek, Inc. | Methods for obtaining microbe-resistant mammalian cells from hypermutable mammalian cells |
US6737268B1 (en) | 2000-11-14 | 2004-05-18 | Morphotek, Inc. | Method for generating genetically altered antigens |
US6958213B2 (en) | 2000-12-12 | 2005-10-25 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function |
US20020086292A1 (en) | 2000-12-22 | 2002-07-04 | Shigeaki Harayama | Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules |
US6982169B2 (en) | 2001-01-15 | 2006-01-03 | Morphotek, Inc. | Chemical inhibitors of mismatch repair |
US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
EP1356037B1 (de) | 2001-01-25 | 2011-03-09 | Evolva Ltd. | Zellbibliothek |
AU2002255907A1 (en) * | 2001-03-23 | 2002-10-08 | William M. Muir | Incorporation of competitive effects in breeding program to increase performance levels and improve animal well being |
AU2002307340A1 (en) | 2001-04-16 | 2002-10-28 | California Institute Of Technology | Peroxide-driven cytochrome p450 oxygenase variants |
US7226768B2 (en) | 2001-07-20 | 2007-06-05 | The California Institute Of Technology | Cytochrome P450 oxygenases |
US20030068808A1 (en) * | 2001-07-25 | 2003-04-10 | Nicolaides Nicholas C. | Methods for generating antibiotic resistant microbes and novel antibiotics |
US6943001B2 (en) * | 2001-08-03 | 2005-09-13 | Diversa Corporation | Epoxide hydrolases, nucleic acids encoding them and methods for making and using them |
WO2003012126A2 (en) * | 2001-08-03 | 2003-02-13 | Diversa Corporation | Epoxide hydrolases, nucleic acids encoding them and methods for making and using them |
US7758854B2 (en) * | 2001-08-30 | 2010-07-20 | Wisconsin Alumni Research Foundation | Anti-microbial agents |
US7323618B2 (en) * | 2002-02-01 | 2008-01-29 | Origen Therapeutics, Inc. | Tissue specific expression of exogenous proteins in transgenic chickens |
US20030166010A1 (en) * | 2002-02-25 | 2003-09-04 | Affholter Joseph A. | Custom ligand design for biomolecular filtration and purification for bioseperation |
DK2315145T3 (en) | 2002-03-01 | 2016-01-25 | Codexis Mayflower Holdings Llc | Methods, systems, and software for identifying the functional biomolecules |
US7620500B2 (en) | 2002-03-09 | 2009-11-17 | Maxygen, Inc. | Optimization of crossover points for directed evolution |
US7226771B2 (en) | 2002-04-19 | 2007-06-05 | Diversa Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
BR0309391A (pt) | 2002-04-19 | 2005-10-25 | Diversa Corp | Fosfolipases, ácidos nucléicos codificando-as e métodos para preparar e usá-las |
IL164687A0 (en) | 2002-05-02 | 2005-12-18 | Univ North Carolina | Cellular libraries and methods for the preparationthereof |
ES2285118T5 (es) | 2002-05-17 | 2012-09-21 | Alligator Bioscience Ab | Un método para el desarrollo molecular in vitro de una función proteica. |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
EP1551988B1 (de) * | 2002-07-19 | 2010-11-24 | Morphotek, Inc. | VERFAHREN ZUR ERZEUGUNG VERBESSERTER ANTIKöRPER PRODUZIERENDER ZELLINIEN MIT VERBESSERTEN WACHSTUMSEIGENSCHAFTEN |
AU2003247270A1 (en) * | 2002-08-01 | 2004-03-03 | Evolva Ltd | Methods of mixing large numbers of heterologous genes |
BR0313281A (pt) | 2002-08-06 | 2007-07-24 | Verdia Inc | variantes de ap1 amina oxidase |
AU2003303288B2 (en) * | 2002-08-16 | 2006-12-07 | Microchips, Inc. | Controlled release device and method |
US7252942B2 (en) * | 2002-12-19 | 2007-08-07 | E.I. Du Pont De Nemours And Company | Parallel chromosomal stacking of traits in bacteria |
ES2713024T3 (es) | 2003-03-06 | 2019-05-17 | Basf Enzymes Llc | Amilasas, ácidos nucleicos que las codifican y métodos para su fabricación y uso |
US8298799B2 (en) | 2003-03-07 | 2012-10-30 | Dsm Ip Assets B. V. | Hydrolases, nucleic acids encoding them and methods for making and using them |
CA2521402C (en) | 2003-04-04 | 2015-01-13 | Diversa Corporation | Pectate lyases, nucleic acids encoding them and methods for making and using them |
EP2322629A3 (de) | 2003-04-29 | 2011-11-02 | Pioneer Hi-Bred International Inc. | Neue Glyphosat-N-Acetyltransferase-Gene |
WO2005001051A2 (en) * | 2003-06-06 | 2005-01-06 | Arborgen Llc. | Compositions and methods for regulating polysaccharides of a plant cell |
WO2005017105A2 (en) | 2003-06-17 | 2005-02-24 | California University Of Technology | Regio- and enantioselective alkane hydroxylation with modified cytochrome p450 |
AU2004254640B2 (en) | 2003-07-02 | 2010-08-26 | Bp Corporation North America Inc. | Glucanases, nucleic acids encoding them and methods for making and using them |
US7741089B2 (en) | 2003-08-11 | 2010-06-22 | Verenium Corporation | Laccases, nucleic acids encoding them and methods for making and using them |
DK1660646T3 (en) | 2003-08-11 | 2015-03-09 | California Inst Of Techn | Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use |
US7516086B2 (en) | 2003-09-24 | 2009-04-07 | Idearc Media Corp. | Business rating placement heuristic |
US7050990B1 (en) | 2003-09-24 | 2006-05-23 | Verizon Directories Corp. | Information distribution system |
EP1542074A1 (de) * | 2003-12-11 | 2005-06-15 | Heptagon OY | Herstellung eines Werkzeugs zur Vervielfältigung |
EP1751180A4 (de) * | 2004-02-26 | 2012-01-04 | Israel State | Enzyme, zellen und verfahren zur stellenspezifischen rekombination an asymmetrischen stellen |
US8055553B1 (en) | 2006-01-19 | 2011-11-08 | Verizon Laboratories Inc. | Dynamic comparison text functionality |
DK1754052T3 (en) * | 2004-06-03 | 2015-09-28 | Phylogica Ltd | Modulators with biochemical properties |
AU2005252266B8 (en) | 2004-06-08 | 2011-03-03 | Microbiogen Pty Ltd | Non-recombinant saccharomyces strains that grow on xylose |
AU2005264938B2 (en) | 2004-06-16 | 2011-11-24 | Verenium Corporation | Compositions and methods for enzymatic decolorization of chlorophyll |
US20060003454A1 (en) * | 2004-07-02 | 2006-01-05 | Conjugon, Inc. | Non-dividing donor cells for gene transfer |
US7799906B1 (en) | 2004-09-22 | 2010-09-21 | Arborgen, Llc | Compositions and methods for modulating lignin of a plant |
EP1817413B1 (de) | 2004-11-11 | 2012-01-04 | Modular Genetics, Inc. | Oligonukleotid-leiterkonstruktion und system zur erzeugung von molekularer vielfalt |
US20060105375A1 (en) * | 2004-11-16 | 2006-05-18 | Bachmann Brian O | Bioretrosynthetic methods for preparing products and compositions related thereto |
CA2614769A1 (en) | 2005-03-10 | 2006-09-21 | Verenium Corporation | Lyase enzymes, nucleic acids encoding them and methods for making and using them |
JP2006246792A (ja) * | 2005-03-10 | 2006-09-21 | Bussan Nanotech Research Institute Inc | 微生物検出方法及び溶菌試薬 |
EP1861506B1 (de) | 2005-03-15 | 2015-04-15 | BP Corporation North America Inc. | Cellulasen, dafür codierende nukleinsäuren und verfahren zur herstellung und verwendung davon |
US8715988B2 (en) | 2005-03-28 | 2014-05-06 | California Institute Of Technology | Alkane oxidation by modified hydroxylases |
US11214817B2 (en) | 2005-03-28 | 2022-01-04 | California Institute Of Technology | Alkane oxidation by modified hydroxylases |
US20060270040A1 (en) * | 2005-05-26 | 2006-11-30 | Conjugon, Inc. | Compositions and methods for treating tissue |
GB2432366B (en) * | 2005-11-19 | 2007-11-21 | Alligator Bioscience Ab | A method for in vitro molecular evolution of protein function |
EP1987142A4 (de) | 2006-02-02 | 2009-07-15 | Verenium Corp | Esterasen und damit zusammenhängende nukleinsäuren und verfahren |
NZ595499A (en) | 2006-02-10 | 2013-05-31 | Verenium Corp | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
US8043839B2 (en) | 2006-02-14 | 2011-10-25 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
EA029538B1 (ru) | 2006-03-07 | 2018-04-30 | Басф Энзаймс Ллк | Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида |
CN101437954B (zh) | 2006-03-07 | 2015-09-09 | 嘉吉公司 | 醛缩酶和编码醛缩酶的核酸以及它们的制备和使用方法 |
CA2658483A1 (en) | 2006-07-21 | 2008-01-24 | Xyleco, Inc. | Conversion systems for biomass |
US8252559B2 (en) | 2006-08-04 | 2012-08-28 | The California Institute Of Technology | Methods and systems for selective fluorination of organic molecules |
WO2008016709A2 (en) | 2006-08-04 | 2008-02-07 | California Institute Of Technology | Methods and systems for selective fluorination of organic molecules |
BRPI0714876B1 (pt) | 2006-08-04 | 2022-04-19 | Verenium Corporation | Ácido nucleico isolado, sintético ou recombinante, cassete de expressão, vetor ou veículo de clonagem, célula bacteriana, fúngica ou de levedura transformada, polipeptídeo isolado, sintético ou recombinante, composição, bem como métodos de produção e de usos dos mesmos |
EP2617814B1 (de) | 2006-09-21 | 2015-11-18 | BASF Enzymes LLC | Phytasen, dafür kodierende Nukleinsäuren sowie Verfahren zu deren Herstellung und Verwendung |
WO2008036863A2 (en) | 2006-09-21 | 2008-03-27 | Verenium Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
EP2479266B1 (de) | 2006-12-21 | 2016-03-09 | BASF Enzymes LLC | Amylasen und Glucoamylasen, dafür kodierende Nukleinsäuren sowie Verfahren zu ihrer Herstellung und Verwendung |
NZ598285A (en) | 2007-01-30 | 2013-10-25 | Syngenta Participations Ag | Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them |
BRPI0811967B1 (pt) | 2007-06-01 | 2023-01-17 | Terravia Holdings, Inc | Microalga chlorella ou prototheca e método para produção de lipídios microbianos |
EP2205744B1 (de) | 2007-10-03 | 2015-01-14 | BP Corporation North America Inc. | Xylenasen, dafür codierende nukleinsäuren und verfahren zur herstellung und verwendung davon |
FR2923491B1 (fr) | 2007-11-14 | 2012-12-14 | Deinove Sa | Utilisation de bacteries pour la production de sources de bioenergie |
WO2009068604A1 (en) | 2007-11-27 | 2009-06-04 | Vib Vzw | Marker assisted directed evolution |
JP5563990B2 (ja) | 2008-01-03 | 2014-07-30 | ヴェレニウム コーポレイション | トランスフェラーゼおよびオキシドレダクターゼ、それらをコードする核酸並びにそれらを製造および使用する方法 |
CA2710922A1 (en) | 2008-01-03 | 2009-07-16 | Verenium Corporation | Isomerases, nucleic acids encoding them and methods for making and using them |
EP2297310A2 (de) | 2008-05-23 | 2011-03-23 | E. I. du Pont de Nemours and Company | Neue dgat-gene für gesteigerte samenspeicherlipidproduktion und veränderte fettsäureprofile bei ölsamenpflanzen |
US8153391B2 (en) | 2008-08-29 | 2012-04-10 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
US8198062B2 (en) | 2008-08-29 | 2012-06-12 | Dsm Ip Assets B.V. | Hydrolases, nucleic acids encoding them and methods for making and using them |
US8357503B2 (en) | 2008-08-29 | 2013-01-22 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
EP2346995B1 (de) | 2008-09-26 | 2018-11-07 | Tocagen Inc. | Gentherapie-vektoren und cytosin-deaminasen |
US9695403B2 (en) | 2009-05-21 | 2017-07-04 | Syngenta Participations Ag | Phytases, nucleic acids encoding them and methods for making and using them |
DK2478137T3 (da) | 2009-09-18 | 2017-11-27 | Codexis Inc | Reduceret kodonmutagenese |
UA109884C2 (uk) | 2009-10-16 | 2015-10-26 | Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування | |
UA111708C2 (uk) | 2009-10-16 | 2016-06-10 | Бандж Ойлз, Інк. | Спосіб рафінування олії |
US20110294170A1 (en) | 2010-05-28 | 2011-12-01 | Codexis, Inc. | Pentose Fermentation By a Recombinant Microorganism |
CA2805803A1 (en) | 2010-08-13 | 2012-02-16 | Pioneer Hi-Bred International, Inc. | Compositions and methods comprising sequences having hydroxyphenylpyruvate dioxygenase (hppd) activity |
WO2012024662A2 (en) | 2010-08-20 | 2012-02-23 | Codexis, Inc. | Expression constructs comprising fungal promoters |
US9493802B2 (en) | 2010-08-20 | 2016-11-15 | Codexis, Inc. | Use of glycohydrolase 61 protein variants with improved thermostability for processing cellulose |
AR083354A1 (es) | 2010-10-06 | 2013-02-21 | Bp Corp North America Inc | Polipeptidos variantes cbh i (celobiohidrolasas i) con reducida inhibicion de producto |
CN102199624B (zh) * | 2011-03-24 | 2013-01-23 | 北京济福霖生物技术有限公司 | 一种利用人工染色体在乳腺中高效生产重组蛋白的方法 |
EP2691517A4 (de) | 2011-03-30 | 2015-04-22 | Codexis Inc | Pentosefermentierung durch einen rekombinanten mikroorganismus |
US8778652B2 (en) | 2011-06-30 | 2014-07-15 | Codexis, Inc. | Pentose fermentation by a recombinant microorganism |
WO2013016207A2 (en) | 2011-07-22 | 2013-01-31 | California Institute Of Technology | Stable fungal cel6 enzyme variants |
BR112014004171A2 (pt) | 2011-08-22 | 2018-11-06 | Codexis Inc | variantes da proteína glicósideo hidrolase gh61 e cofatores que aumentam a atividade de gh61 |
WO2013048661A1 (en) | 2011-09-30 | 2013-04-04 | Codexis, Inc. | Fungal proteases |
US9611462B2 (en) | 2011-12-20 | 2017-04-04 | Codexis, Inc. | Endoglucanase 1B (EG1B) variants |
CN104411823A (zh) | 2012-05-04 | 2015-03-11 | 纳幕尔杜邦公司 | 包含具有大范围核酸酶活性的序列的组合物和方法 |
BR112014031024A2 (pt) | 2012-06-11 | 2017-06-27 | Codexis Inc | xilanases e xilosidases fúngicas. |
WO2014060973A1 (en) | 2012-10-19 | 2014-04-24 | Indian Oil Corporation Limited | Improved microalgae strains and use thereof |
US9663532B2 (en) | 2012-10-29 | 2017-05-30 | University Of Rochester | Artemisinin derivatives, methods for their preparation and their use as antimalarial agents |
AU2013348272A1 (en) | 2012-11-20 | 2015-05-14 | Shell Internationale Research Maatschappij B.V. | Pentose fermentation by a recombinant microorganism |
WO2014083534A1 (en) | 2012-11-29 | 2014-06-05 | Indian Oil Corporation Limited | Mixotrophic cultivation of microalgae for the production of biofuel |
GB201308828D0 (en) | 2013-03-12 | 2013-07-03 | Verenium Corp | Phytase |
GB201308843D0 (en) | 2013-03-14 | 2013-07-03 | Verenium Corp | Phytase formulation |
EP2970935A1 (de) | 2013-03-14 | 2016-01-20 | Pioneer Hi-Bred International, Inc. | Zusammensetzungen mit dicamba-decarboxylaseaktivität und verfahren zur verwendung |
BR112015023272A2 (pt) | 2013-03-14 | 2017-07-18 | Pioneer Hi Bred Int | célula vegetal, planta, explante vegetal, semente transgênica, método para produzir uma célula vegetal tendo um polinucleotídeo heterólogo que codifica um polipeptídeo tendo atividade de dicamba descarboxilase, método para controlar plantas daninhas em um campo contendo uma cultura e método para controlar plantas daninhas em um campo contendo uma cultura |
RU2015143825A (ru) | 2013-03-15 | 2017-04-26 | Пайонир Хай-Бред Интернэшнл, Инк. | Полипептиды phi-4 и способы их применения |
KR102218930B1 (ko) | 2013-04-18 | 2021-02-23 | 코덱시스, 인코포레이티드 | 조작된 페닐알라닌 암모니아 리아제 폴리펩티드 |
KR20230122182A (ko) * | 2013-07-09 | 2023-08-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 멀티플렉스 rna-가이드된 게놈 조작 |
CN105408492A (zh) | 2013-07-25 | 2016-03-16 | 巴斯夫酶有限责任公司 | 肌醇六磷酸酶 |
EA030896B1 (ru) | 2013-08-16 | 2018-10-31 | Пайонир Хай-Бред Интернэшнл, Инк. | Инсектицидные белки и способы их применения |
BR112016005543B1 (pt) | 2013-09-13 | 2022-03-08 | Pioneer Hi-Bred International, Inc | Polipeptídeo pip-72 recombinante, construto de dna, método de obtenção de planta transgênica, célula hospedeira, composição, proteína de fusão, método para controlar uma população de praga de inseto, método para inibir o crescimento ou matar uma praga de inseto, método para controlar uma infestação de insetos em uma planta transgênica, método para identificar em uma amostra biológica uma sequência de nucleotídeos, método para identificar em uma amostra um polipeptídeo pip-72 |
WO2015048572A1 (en) | 2013-09-27 | 2015-04-02 | Codexis, Inc. | Automated screening of enzyme variants |
WO2015073555A1 (en) | 2013-11-13 | 2015-05-21 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
EP3087088B1 (de) | 2013-12-23 | 2022-05-25 | University Of Rochester | Verfahren und zusammensetzungen zur ribosomalen synthese von makrocyclischen peptiden |
BR112016018103B1 (pt) | 2014-02-07 | 2024-01-16 | E.I. Du Pont De Nemours And Company | Polipeptídeo e seu uso, polinucleotídeo, composição, proteína de fusão, método para controlar uma população, método para inibir o crescimento, método para controlar a infestação, método para obtenção de uma planta ou célula vegetal, construto |
BR112016018287A2 (pt) | 2014-02-07 | 2017-10-10 | Du Pont | proteínas inseticidas e métodos para uso das mesmas |
US9605252B2 (en) | 2014-04-16 | 2017-03-28 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
DK3167052T3 (da) | 2014-07-09 | 2020-02-10 | Codexis Inc | P450-bm3-varianter med forbedret aktivitet |
CA2963558C (en) | 2014-10-16 | 2023-04-04 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2016085916A1 (en) | 2014-11-25 | 2016-06-02 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
LT3237621T (lt) | 2014-12-22 | 2023-09-25 | Codexis, Inc. | Žmogaus alfa-galaktozidazės variantai |
US10696953B2 (en) | 2015-02-10 | 2020-06-30 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
WO2016144688A1 (en) | 2015-03-11 | 2016-09-15 | Pioneer Hi Bred International Inc | Insecticidal combinations of pip-72 and methods of use |
KR102604503B1 (ko) | 2015-05-07 | 2023-11-20 | 코덱시스, 인코포레이티드 | 페니실린-g 아실라아제 |
CN108064233B (zh) | 2015-05-19 | 2022-07-15 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
CN108271374B (zh) | 2015-07-07 | 2021-09-21 | 科德克希思公司 | 具有改进的活性的新颖p450-bm3变体 |
EP3331352B1 (de) | 2015-08-06 | 2022-07-06 | Pioneer Hi-Bred International, Inc. | Von pflanzen abstammende insektizide proteine und verfahren zu deren verwendung |
CN108368475A (zh) * | 2015-11-25 | 2018-08-03 | 拉金德拉·苏拉纳 | 通过经改良酵母菌株酿酒酵母在高温下生产高量乙醇的方法 |
EP3858996B1 (de) * | 2015-12-07 | 2022-08-03 | Zymergen Inc. | Verbesserung eines mikrobiellen stammes durch eine htp-genom-engineering-plattform |
US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
WO2017100376A2 (en) | 2015-12-07 | 2017-06-15 | Zymergen, Inc. | Promoters from corynebacterium glutamicum |
US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
WO2017105987A1 (en) | 2015-12-18 | 2017-06-22 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
US11008585B2 (en) | 2016-05-04 | 2021-05-18 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
EP3452587B1 (de) | 2016-05-05 | 2021-09-08 | Codexis, Inc. | Penicillin-g-acylasen |
US10184117B2 (en) | 2016-06-09 | 2019-01-22 | Codexis, Inc. | Biocatalysts and methods for hydroxylation of chemical compounds |
KR20190018512A (ko) | 2016-06-15 | 2019-02-22 | 코덱시스, 인코포레이티드 | 조작된 베타-글루코시다아제 및 글루코실화 방법 |
WO2017215790A1 (en) | 2016-06-17 | 2017-12-21 | National Hellenic Research Foundation | Systems for recombinant protein production |
JP2019519242A (ja) | 2016-06-30 | 2019-07-11 | ザイマージェン インコーポレイテッド | 細菌ヘモグロビンライブラリーを生成するための方法およびその使用 |
US10544411B2 (en) | 2016-06-30 | 2020-01-28 | Zymergen Inc. | Methods for generating a glucose permease library and uses thereof |
WO2018005411A1 (en) | 2016-07-01 | 2018-01-04 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
CN109863162B (zh) | 2016-08-26 | 2023-03-17 | 科德克希思公司 | 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
US11021716B2 (en) | 2016-11-01 | 2021-06-01 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
BR112019012339A2 (pt) | 2016-12-14 | 2019-11-26 | Pioneer Hi Bred Int | polipeptídeo inseticida recombinante, composição, construto de dna, célula hospedeira, planta transgênica, método para inibir o crescimento ou extermínio de uma praga de inseto ou população de praga, polipeptídeo ipd093 quimérico e proteína de fusão |
CA3046226A1 (en) | 2016-12-22 | 2018-06-28 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
CA3048475A1 (en) | 2017-01-05 | 2018-07-12 | Codexis, Inc. | Penicillin-g acylases |
EP3577229A4 (de) | 2017-02-03 | 2020-12-23 | Codexis, Inc. | Manipulierte glycosyltransferasen und verfahren zur steviol-glycosid-glucosylierung |
CA3052794A1 (en) | 2017-02-08 | 2018-08-16 | Pioneer Hi-Bred International, Inc. | Insecticidal combinations of plant derived insecticidal proteins and methods for their use |
NZ755628A (en) | 2017-02-13 | 2023-09-29 | Codexis Inc | Engineered phenylalanine ammonia lyase polypeptides |
JP7045725B2 (ja) | 2017-04-27 | 2022-04-01 | コデクシス, インコーポレイテッド | ケトレダクターゼポリペプチドおよびポリヌクレオチド |
CA3062550A1 (en) | 2017-05-08 | 2018-11-15 | Codexis, Inc. | Engineered ligase variants |
CA3063200A1 (en) | 2017-05-11 | 2018-11-15 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
ES2875579T3 (es) * | 2017-06-06 | 2021-11-10 | Zymergen Inc | Plataforma de ingeniería genómica de HTP para mejorar Escherichia coli |
EP3635110A2 (de) * | 2017-06-06 | 2020-04-15 | Zymergen, Inc. | Genomische hochdurchsatz-plattform (htp) zur verbesserung von saccharopolyspora spinosa |
JP7122009B2 (ja) | 2017-06-14 | 2022-08-19 | コデクシス, インコーポレイテッド | 産業上の生体触媒作用のための操作されたトランスアミナーゼポリペプチド |
US11643642B2 (en) | 2017-06-27 | 2023-05-09 | Codexis, Inc. | Penicillin-g acylases |
CA3066767A1 (en) | 2017-06-30 | 2019-01-03 | Codexis, Inc. | T7 rna polymerase variants |
KR20200023455A (ko) | 2017-06-30 | 2020-03-04 | 코덱시스, 인코포레이티드 | T7 rna 폴리머라제 변이체 |
EP3668306A4 (de) * | 2017-08-17 | 2021-06-09 | Cargill, Incorporated | Genetisch modifizierte haploidissatchenkia orientalis |
WO2019040335A1 (en) | 2017-08-19 | 2019-02-28 | University Of Rochester | MICHELOLID DERIVATIVES, PREPARATION METHODS AND THEIR USE AS ANTICANCER AND ANTI-INFLAMMATORY AGENTS |
ES2704201B2 (es) * | 2017-09-14 | 2019-11-18 | Tomsa Destil S L | Cepa de Saccharomyces cerevisiae y su uso para la elaboración de productos alcohólicos |
CN111511389A (zh) | 2017-11-07 | 2020-08-07 | 科德克希思公司 | 转谷氨酰胺酶变体 |
US11015180B2 (en) | 2017-12-13 | 2021-05-25 | Codexis, Inc. | Carboxyesterase polypeptides for amide coupling |
US11708571B2 (en) | 2018-05-17 | 2023-07-25 | Bp Corporation North America Inc. | Production of 2-keto-3-deoxy-d-gluconic acid in filamentous fungi |
WO2019241132A1 (en) | 2018-06-12 | 2019-12-19 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
SG11202012138XA (en) | 2018-07-09 | 2021-01-28 | Codexis Inc | Engineered galactose oxidase variant enzymes |
JP2021530216A (ja) | 2018-07-09 | 2021-11-11 | コデクシス, インコーポレイテッド | 操作されたパントテン酸キナーゼ改変体酵素 |
KR20210031933A (ko) | 2018-07-09 | 2021-03-23 | 코덱시스, 인코포레이티드 | 조작된 포스포펜토뮤타제 변이체 효소 |
CA3103718A1 (en) | 2018-07-09 | 2020-01-16 | Codexis, Inc. | Engineered purine nucleoside phosphorylase variant enzymes |
WO2020014048A1 (en) | 2018-07-09 | 2020-01-16 | Codexis, Inc. | Engineered deoxyribose-phosphate aldolases |
CA3105916A1 (en) | 2018-07-12 | 2020-01-16 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
KR20210040408A (ko) | 2018-07-30 | 2021-04-13 | 코덱시스, 인코포레이티드 | 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법 |
US20220025391A1 (en) | 2018-09-07 | 2022-01-27 | Basf Plant Science Company Gmbh | Improved method for the production of high levels of pufa in plants |
EP3847262A1 (de) | 2018-09-07 | 2021-07-14 | Basf Plant Science Company GmbH | Verbessertes verfahren zur herstellung von hohen pufa-spiegeln in pflanzen |
AU2019334672A1 (en) | 2018-09-07 | 2021-03-25 | Basf Plant Science Company Gmbh | Improved method for the production of high levels of PUFA in plants |
BR112021008186A2 (pt) | 2018-10-29 | 2021-08-17 | Codexis, Inc. | dna polimerase projetada, sequência polinucleotídica, vetor de expressão, célula hospedeira, composição, sistema de ensaio de alto rendimento, e, métodos para produção de um polipeptídeo de dna polimerase projetado em uma célula hospedeira e para determinação de fidelidade de alto rendimento de uma dna polimerase. |
SG11202105668PA (en) | 2018-12-14 | 2021-06-29 | Codexis Inc | Engineered tyrosine ammonia lyase |
US11427813B2 (en) | 2018-12-20 | 2022-08-30 | Codexis, Inc. | Human alpha-galactosidase variants |
BR112022011895A2 (pt) | 2019-12-20 | 2022-09-06 | Basf Se | Diminuição da toxidez de terpenos e aumento da produção potencial em microrganismos |
JP2023521772A (ja) | 2020-04-10 | 2023-05-25 | コデクシス, インコーポレイテッド | 操作されたトランスアミナーゼポリペプチド |
WO2021245064A1 (en) | 2020-06-04 | 2021-12-09 | Isobionics B.V. | Synthetic santalene synthases |
CN111513024A (zh) * | 2020-06-19 | 2020-08-11 | 宁夏绿方水产良种繁育有限公司 | 一种提高成活率的甲鱼养殖方法 |
BR112022027035A2 (pt) | 2020-07-14 | 2023-04-11 | Pioneer Hi Bred Int | Proteínas inseticidas e métodos para uso das mesmas |
JP2023539632A (ja) | 2020-08-28 | 2023-09-15 | コデクシス, インコーポレイテッド | 操作されたプロテアーゼバリアント |
EP4204552A1 (de) | 2020-08-28 | 2023-07-05 | Codexis, Inc. | Manipulierte amylasevarianten |
US11898174B2 (en) | 2020-12-18 | 2024-02-13 | Codexis, Inc. | Engineered uridine phosphorylase variant enzymes |
EP4015626A1 (de) | 2020-12-18 | 2022-06-22 | Isobionics B.V. | Enzyme und verfahren zur fermentativen herstellung von monoterpenestern |
IL305922A (en) | 2021-04-02 | 2023-11-01 | Codexis Inc | Transgenic enzymes of variant guanylate kinase |
CA3214975A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered cyclic gmp-amp synthase (cgas) variant enzymes |
US11913036B2 (en) | 2021-04-02 | 2024-02-27 | Codexis, Inc. | Engineered acetate kinase variant enzymes |
CN117120600A (zh) | 2021-04-02 | 2023-11-24 | 科德克希思公司 | 工程化腺苷酸激酶变体酶 |
CN117795087A (zh) | 2021-08-02 | 2024-03-29 | 巴斯夫欧洲公司 | 用紫罗兰亚基乙烷合酶进行的芳香化合物的新颖生产 |
WO2023173084A1 (en) | 2022-03-11 | 2023-09-14 | University Of Rochester | Cyclopeptibodies and uses thereof |
WO2024040020A1 (en) | 2022-08-15 | 2024-02-22 | Absci Corporation | Quantitative affinity activity specific cell enrichment |
Family Cites Families (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54163880A (en) | 1978-04-26 | 1979-12-26 | Glaxo Group Ltd | Improvement in cephalosporin production |
CA1220733A (en) * | 1982-12-27 | 1987-04-21 | Shigeru Takahashi | Method for promoting fusion of plant protoplast |
HU194306B (en) | 1983-05-16 | 1988-01-28 | Gyogyszerkutato Intezet | Process for influencing biosynthesis of antibiotics with in vivo genetical recombination |
US4940834A (en) | 1983-12-05 | 1990-07-10 | Lofts, Inc. | Plants having endophytio-fungus-enhanced performance and method of producing same |
DE3546807C2 (de) | 1985-03-30 | 1991-03-28 | Marc Genf/Geneve Ch Ballivet | |
US5866363A (en) | 1985-08-28 | 1999-02-02 | Pieczenik; George | Method and means for sorting and identifying biological information |
US5824469A (en) | 1986-07-17 | 1998-10-20 | University Of Washington | Method for producing novel DNA sequences with biological activity |
US4940839A (en) * | 1986-10-01 | 1990-07-10 | Dna Plant Technology Corporation | Method of tomato protoplast fusion and regeneration of hybrid plants therefrom |
US5763192A (en) | 1986-11-20 | 1998-06-09 | Ixsys, Incorporated | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
US4889806A (en) | 1987-04-15 | 1989-12-26 | Washington University | Large DNA cloning system based on yeast artificial chromosomes |
ATE105585T1 (de) | 1987-12-21 | 1994-05-15 | Univ Toledo | Transformation von keimenden pflanzensamen mit hilfe von agrobacterium. |
FR2641793B1 (fr) | 1988-12-26 | 1993-10-01 | Setratech | Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases |
DD282028A5 (de) | 1989-02-16 | 1990-08-29 | Akad Wissenschaften Ddr | Verfahren zur herstellung einer thermostabilen, hybriden bacillus-beta-1,3-1,4-glukanase |
JP2855130B2 (ja) | 1989-07-19 | 1999-02-10 | 吉富製薬株式会社 | 異種蛋白発現用融合酵母菌、該菌の製造方法および異種蛋白の製造方法 |
DE69033493D1 (de) | 1989-07-25 | 2004-08-12 | Cell Genesys Inc | Homologe rekombination für universelle donorzellen und chimerische säugetierzellen |
US5574205A (en) | 1989-07-25 | 1996-11-12 | Cell Genesys | Homologous recombination for universal donor cells and chimeric mammalian hosts |
US5426040A (en) * | 1989-08-17 | 1995-06-20 | Northeastern University | Methods for producing improved strains of seaweed by fusion of spore-protoplasts, and resultant seaweeds and phycocolloids |
CA2067797C (en) | 1989-10-18 | 1997-03-04 | Charles R. King | Production and use of human nm23 protein and antibodies therefor |
ES2090297T5 (es) | 1989-11-06 | 2005-03-01 | Cell Genesys, Inc. | Produccion de proteinas que utilizan recombinacion homologa. |
US5877402A (en) | 1990-05-01 | 1999-03-02 | Rutgers, The State University Of New Jersey | DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein |
AU664976B2 (en) | 1990-08-29 | 1995-12-14 | Gene Pharming Europe Bv | Homologous recombination in mammalian cells |
WO1992017598A1 (en) * | 1991-03-29 | 1992-10-15 | The Board Of Trustees Of The University Of Illinois | Production fo transgenic soybean plants |
US5514568A (en) | 1991-04-26 | 1996-05-07 | Eli Lilly And Company | Enzymatic inverse polymerase chain reaction |
US5512463A (en) | 1991-04-26 | 1996-04-30 | Eli Lilly And Company | Enzymatic inverse polymerase chain reaction library mutagenesis |
US6071889A (en) | 1991-07-08 | 2000-06-06 | Neurospheres Holdings Ltd. | In vivo genetic modification of growth factor-responsive neural precursor cells |
US5843643A (en) | 1992-02-21 | 1998-12-01 | Ratner; Paul L. | Site-specific transfection of eukaryotic cells using polypeptide-linked recombinant nucleic acid |
WO1993019170A1 (en) | 1992-03-16 | 1993-09-30 | Jacob Nathaniel Wohlstadter | Selection methods |
US5763240A (en) | 1992-04-24 | 1998-06-09 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
AU4115693A (en) | 1992-04-24 | 1993-11-29 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
DE4319496A1 (de) | 1992-06-17 | 1994-04-07 | Sandoz Ag | Pilze zur Reduktion des Harzanteils und deren Gewinnung |
WO1995003400A1 (en) | 1993-07-23 | 1995-02-02 | Johns Hopkins University School Of Medicine | Recombinationally targeted cloning in yeast artificial chromosomes |
US5683899A (en) | 1994-02-03 | 1997-11-04 | University Of Hawaii | Methods and compositions for combinatorial-based discovery of new multimeric molecules |
US5643745A (en) | 1994-02-03 | 1997-07-01 | University Of Hawaii | Heterologous dimeric proteins produced in heterokaryons |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5521077A (en) | 1994-04-28 | 1996-05-28 | The Leland Stanford Junior University | Method of generating multiple protein variants and populations of protein variants prepared thereby |
US5605820A (en) | 1994-06-23 | 1997-02-25 | Chemgenics Pharmaceuticals, Inc. | Production of strains having biological activities by sexual crosses between vegetatively incompatible strains of Aspergillus nidulans |
US5514588A (en) | 1994-12-13 | 1996-05-07 | Exxon Research And Engineering Company | Surfactant-nutrients for bioremediation of hydrocarbon contaminated soils and water |
KR100501838B1 (ko) | 1995-04-24 | 2005-07-21 | 큐비스트 파마슈티컬즈 인코포레이티드 | 새로운 대사 경로를 만들고 이를 스크리닝하는 방법 |
US6168919B1 (en) | 1996-07-17 | 2001-01-02 | Diversa Corporation | Screening methods for enzymes and enzyme kits |
US6057103A (en) | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
US5958672A (en) | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
US6004788A (en) | 1995-07-18 | 1999-12-21 | Diversa Corporation | Enzyme kits and libraries |
US6030779A (en) | 1995-07-18 | 2000-02-29 | Diversa Corporation | Screening for novel bioactivities |
WO1997007205A1 (en) | 1995-08-11 | 1997-02-27 | Novo Nordisk A/S | Method for preparing polypeptide variants |
US5962258A (en) | 1995-08-23 | 1999-10-05 | Diversa Corporation | Carboxymethyl cellulase fromthermotoga maritima |
US6051409A (en) | 1995-09-25 | 2000-04-18 | Novartis Finance Corporation | Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells |
US5962283A (en) | 1995-12-07 | 1999-10-05 | Diversa Corporation | Transminases and amnotransferases |
US5830696A (en) | 1996-12-05 | 1998-11-03 | Diversa Corporation | Directed evolution of thermophilic enzymes |
US20030215798A1 (en) | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
US6489145B1 (en) | 1996-07-09 | 2002-12-03 | Diversa Corporation | Method of DNA shuffling |
US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
US5814473A (en) | 1996-02-09 | 1998-09-29 | Diversa Corporation | Transaminases and aminotransferases |
US5773221A (en) | 1995-12-15 | 1998-06-30 | Oceanix Biosciences Corporation | Method of recovering a biological molecule from a recombinant microorganism |
AU1367897A (en) | 1996-01-10 | 1997-08-01 | Novo Nordisk A/S | A method for in vivo production of a mutant library in cells |
US5942430A (en) | 1996-02-16 | 1999-08-24 | Diversa Corporation | Esterases |
US5958751A (en) | 1996-03-08 | 1999-09-28 | Diversa Corporation | α-galactosidase |
US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
US5789228A (en) | 1996-05-22 | 1998-08-04 | Diversa Corporation | Endoglucanases |
US5877001A (en) | 1996-06-17 | 1999-03-02 | Diverso Corporation | Amidase |
US5763239A (en) | 1996-06-18 | 1998-06-09 | Diversa Corporation | Production and use of normalized DNA libraries |
ATE278416T1 (de) | 1996-06-19 | 2004-10-15 | Diversa Corp | Thermostabilen phosphatasen |
US5939300A (en) | 1996-07-03 | 1999-08-17 | Diversa Corporation | Catalases |
CA2259158A1 (en) | 1996-07-09 | 1998-01-15 | The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services | Transformation-associated recombination cloning |
US5869718A (en) | 1996-07-15 | 1999-02-09 | Julien; Jean-Pierre | Homologous recombination for animal model exhibiting reduced levels or elimination of a neuronal intermediate filament protein |
US6093873A (en) | 1996-08-19 | 2000-07-25 | Institut National De La Sante Et De La Recherche Medicale | Genetically engineered mice containing alterations in the gene encoding RXR |
US6173410B1 (en) | 1996-08-21 | 2001-01-09 | Texas Instruments Incorporated | Microprocessor circuits, systems and methods for conditioning information prefetching based on resource burden |
WO1998013485A1 (en) | 1996-09-27 | 1998-04-02 | Maxygen, Inc. | Methods for optimization of gene therapy by recursive sequence shuffling and selection |
AU4503797A (en) | 1996-09-27 | 1998-04-17 | Maxygen, Inc. | Methods for optimization of gene therapy by recursive sequence shuffling and selection |
CA2274112A1 (en) | 1996-12-06 | 1998-06-11 | Diversa Corporation | Glycosidase enzymes |
CN1208456C (zh) | 1996-12-20 | 2005-06-29 | 诺维信公司 | 体内重组 |
IL130635A0 (en) | 1997-01-17 | 2000-06-01 | Maxygen Inc | Evolution of whole cells and organisms by recursive sequence recombination |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
US7148054B2 (en) | 1997-01-17 | 2006-12-12 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
US5929250A (en) | 1997-01-23 | 1999-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
EP0970224A1 (de) | 1997-02-13 | 2000-01-12 | The Dow Chemical Company | Rekombinante haloaliphatische dehalogenasen |
US6387862B2 (en) | 1997-03-07 | 2002-05-14 | The Procter & Gamble Company | Bleach compositions |
EP1015575B1 (de) | 1997-03-18 | 2010-05-19 | Novozymes A/S | Vermischen von heterologen dns-sequenzen |
JP4263248B2 (ja) | 1997-03-18 | 2009-05-13 | ノボザイムス アクティーゼルスカブ | Dnaのシャッフリングによるライブラリーの作成方法 |
IL131966A0 (en) | 1997-03-18 | 2001-03-19 | Novo Industri As | An in vitro method for construction of a dna library |
US6159687A (en) | 1997-03-18 | 2000-12-12 | Novo Nordisk A/S | Methods for generating recombined polynucleotides |
US6159688A (en) | 1997-03-18 | 2000-12-12 | Novo Nordisk A/S | Methods of producing polynucleotide variants |
US5948653A (en) | 1997-03-21 | 1999-09-07 | Pati; Sushma | Sequence alterations using homologous recombination |
US6153410A (en) | 1997-03-25 | 2000-11-28 | California Institute Of Technology | Recombination of polynucleotide sequences using random or defined primers |
KR20000022108A (ko) | 1997-04-22 | 2000-04-25 | 한스 발터 라벤 | 탈아실화된 세팔로스포린의 발효제조방법 |
US6051049A (en) | 1997-05-29 | 2000-04-18 | Exothermic Distribution Corporation | Utilization of strontium aluminate in steelmaking |
US5948666A (en) | 1997-08-06 | 1999-09-07 | Diversa Corporation | Isolation and identification of polymerases |
US5876997A (en) | 1997-08-13 | 1999-03-02 | Diversa Corporation | Phytase |
US6610528B1 (en) | 1997-08-26 | 2003-08-26 | Diversa Corporation | Microbial enrichment using a container having a plurality of solid support particles |
WO1999014312A1 (en) | 1997-09-12 | 1999-03-25 | University Of Maryland | Preparation and use of biofilm-degrading, multiple-specificity, hydrolytic enzyme mixtures |
US6846627B2 (en) | 1997-10-15 | 2005-01-25 | Diversa Corporation | Screening for novel compounds which regulate biological interactions |
WO1999021979A1 (en) | 1997-10-28 | 1999-05-06 | Maxygen, Inc. | Human papillomavirus vectors |
EP1690868A1 (de) | 1997-10-31 | 2006-08-16 | Maxygen, Inc. | Modifizierung des Virustropismus und des Wirtspektrums durch virale Genomdurchmischung |
US6232112B1 (en) | 1997-11-24 | 2001-05-15 | Flinders Technologies Pty Ltd Of Flinders University | Reagents and methods for diversification of DNA |
AU3291099A (en) | 1998-02-11 | 1999-08-30 | Maxygen, Inc. | Genetic vaccine vector engineering |
WO1999041383A1 (en) | 1998-02-11 | 1999-08-19 | Maxygen, Inc. | Antigen library immunization |
AU744699B2 (en) | 1998-03-04 | 2002-02-28 | Verenium Corporation | Production and use of normalized DNA libraries |
BR9910174A (pt) | 1998-05-01 | 2001-03-06 | Maxygen Inc | Processo para se obter um gene recombinante otimizado de resistência à praga, biblioteca, e, processo para se obter um organismo que seja patogênico a uma praga de vegetal |
AU4441699A (en) | 1998-06-17 | 2000-01-05 | Maxygen, Inc. | Method for producing polynucleotides with desired properties |
EP1108781A3 (de) | 1999-01-19 | 2001-09-12 | Maxygen, Inc. | Verfahren zum Erfassen von Zeichenketten, Polynukleotiden und Polypeptiden |
US6030267A (en) | 1999-02-19 | 2000-02-29 | Micron Technology, Inc. | Alignment method for field emission and plasma displays |
AU3879300A (en) | 1999-03-09 | 2000-09-28 | Diversa Corporation | End selection in directed evolution |
MXPA00011569A (es) | 1999-03-26 | 2004-12-03 | Diversa Corp | Re-ensamble de acidos nucleicos mediado por exonucleasa en evolucion dirigida. |
-
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AU771511B2 (en) | 2004-03-25 |
KR100647112B1 (ko) | 2006-11-17 |
EP1108058A4 (de) | 2003-03-05 |
JP4674329B2 (ja) | 2011-04-20 |
WO2000004190A1 (en) | 2000-01-27 |
ES2257866T3 (es) | 2006-08-01 |
DE69929796T2 (de) | 2006-10-12 |
JP2002520071A (ja) | 2002-07-09 |
JP2010131014A (ja) | 2010-06-17 |
US6335198B1 (en) | 2002-01-01 |
EP1108058A1 (de) | 2001-06-20 |
CA2331263A1 (en) | 2000-01-27 |
ATE317453T1 (de) | 2006-02-15 |
US6716631B1 (en) | 2004-04-06 |
AU5102699A (en) | 2000-02-07 |
EP1707641A3 (de) | 2006-12-27 |
WO2000004190A9 (en) | 2000-08-10 |
CA2331263C (en) | 2011-01-18 |
CA2720311A1 (en) | 2000-01-27 |
US6528311B1 (en) | 2003-03-04 |
US8377681B2 (en) | 2013-02-19 |
IL140121A0 (en) | 2002-02-10 |
US6287862B1 (en) | 2001-09-11 |
KR20010083053A (ko) | 2001-08-31 |
US20120252681A1 (en) | 2012-10-04 |
EP1108058B1 (de) | 2006-02-08 |
EP1707641A2 (de) | 2006-10-04 |
US6326204B1 (en) | 2001-12-04 |
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